CN104586641A - Efficient compound medicine resisting skin aging and preparation method thereof - Google Patents
Efficient compound medicine resisting skin aging and preparation method thereof Download PDFInfo
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- CN104586641A CN104586641A CN201510060785.6A CN201510060785A CN104586641A CN 104586641 A CN104586641 A CN 104586641A CN 201510060785 A CN201510060785 A CN 201510060785A CN 104586641 A CN104586641 A CN 104586641A
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Abstract
The invention relates to an efficient compound medicine resisting skin aging and a preparation method thereof. The efficient compound medicine resisting skin aging is prepared from the following various ingredients in proportion by mass: 0.01-0.1% of retinoic acid, 1-5% of glucosamine hydrochloride or N-acetyl glucosamine and the balance of a cream matrix. The preparation method comprises the following steps: adequately dissolving retinoic acid and glucosamine hydrochloride or N-acetyl glucosamine with the proportions in a corresponding amount of polyethylene glycol and mixing by a container; then mixing the mixture with the cream matrix, and stirring for 30 seconds by a superfine homogenizer to obtain the product. According to the preparation method disclosed by the invention, the dosage of retinoic acid is reduced by virtue of the synergistic effect between retinoic acid and glucosamine hydrochloride or N-acetyl glucosamine, and the functions of moisturizing and improving skin elasticity of retinoic acid are improved while skin irritation and adverse reactions are reduced. The efficient compound medicine resisting skin aging disclosed by the invention is simple in formula and convenient to use, and has the good effects of resisting skin aging, resisting wrinkles, resisting inflammation and fading spots.
Description
Technical field
The present invention relates to skin care item, is high-efficient compound medicine of a kind of anti aging effect and preparation method thereof specifically.
Background technology
Along with the development of society and the raising of living standard, the requirement of people to looks improving and the skin nourishing is also more and more higher.The catabiosis of the skin such as xerosis cutis, coarse, lax, obscure, corse sweat pore, pigmentation, wrinkle becomes old and feeble symbol.
The phenomenon of these skin aginges, it forms existing external factor also has internal factor.Exopathogenic factor many with ultraviolet radiation, environmental pollution is relevant, fecund raw black speck, chloasma, solar dermatitis etc.; Endogenous cause of ill is then many to be increased with free radical, skin renewal metabolism power dies down, skin keratin irregular thickening, skin hydropenia elasticity variation etc. are relevant, easily causes the phenomenon such as wrinkle of skin, coarse, thinning of skin, corse sweat pore.
Found through experiments, tretinoin can desalinate mottle, improve skin aging, there is certain antidotal effect, but, commercially available tretinoin emulsifiable paste, mostly be medicine, be made into concentration (mass percent) be 0.05% or 0.1% unguentum (tretinoin ointment) the most common, for acne vulgaris, flat tongue wart, mucous membrane white spot, pityriasis rubra pilaris, follicular keratosis or psoriatic auxiliary treatment.Use this tretinoin ointment to have certain untoward reaction, it can cause skin irritation symptom, as bright sense, erythema and desquamation, skin lesion may be made more obvious.
Prove by experiment, topical Retinoids reaches 2% concentration (mass percent), or easily quick, dry skin is when using tretinoin, must be very careful, because it has the characteristic of dissolving cutin, may produce significantly dry and desquamation, unsuitable life-time service, needs during use to carry out corresponding replenishing water and preserving moisture nursing simultaneously.The zest of tretinoin and its concentration and have much relations service time, namely working concentration is higher, and service time is longer, larger to the zest of skin.
So, how to utilize the anti-aging effects of tretinoin, reduce again its zest to skin, meanwhile, use it for skin care item, can long-term safety effectively use, reaching delay skin aging, improve the object of skin aging situation, is a problem in the urgent need to address.
Summary of the invention
For the defect existed in prior art, high-efficient compound medicine that the object of the present invention is to provide a kind of anti aging effect and preparation method thereof, it adopts the glucosamine hydrochloride of tretinoin, aminoglucose saccharide or 2-Acetamido-2-deoxy-D-glucose to be main component, formula is simple, safety easy to use, has the effect of good anti aging effect, crease-resistant, antiinflammatory, desalination mottle.
For reaching above object, the technical scheme that the present invention takes is:
A high-efficient compound medicine for anti aging effect, is characterized in that, the quality proportioning of its composition and each composition is as follows:
Tretinoin: 0.01-0.1%, glucosamine hydrochloride or 2-Acetamido-2-deoxy-D-glucose: 1-5%, all the other are cream base.
On technique scheme basis, tretinoin 0.025%, 2-Acetamido-2-deoxy-D-glucose 2%, all the other are cream base, are optimum proportioning.
On technique scheme basis, tretinoin 0.025%, glucosamine hydrochloride 2%, all the other are cream base, are optimum proportioning.
On technique scheme basis, tretinoin adopts all-trans retinoic acid.
On technique scheme basis, cream base selects O/W type cream base or aqueous gel substrate.
The preparation method of the high-efficient compound medicine of anti aging effect as above, step is as follows:
First with a container, the tretinoin of proportional quantity and glucosamine hydrochloride or 2-Acetamido-2-deoxy-D-glucose are fully dissolved in the Polyethylene Glycol of a great deal of;
Again said mixture and cream base are mixed, and stir 30 seconds by ultra-fine homogenizer, obtain product.
On technique scheme basis, described tretinoin selects all-trans retinoic acid;
PEG-4000 selected by described Polyethylene Glycol;
Described cream base selects O/W type cream base or aqueous gel substrate;
Described effective ingredient is dissolved in the Polyethylene Glycol of a great deal of, mixes with the ratio of 600ml PEG-4000 according to every 100mg effective ingredient;
Described ultra-fine refiner is 5000rpm.
On technique scheme basis, the use amount of tretinoin is low to moderate 0.01%, and glucosamine hydrochloride or 2-Acetamido-2-deoxy-D-glucose use amount are low to moderate 1%.
The high-efficient compound medicine of anti aging effect of the present invention, has following effect:
1, desalinate mottle: mainly utilize the tretinoin in component, glucosamine hydrochloride or 2-Acetamido-2-deoxy-D-glucose for effective ingredient, play and suppress epidermal pigment calm, alleviate mottle, improve the effect of the skin aging that uv damage causes;
2, improve degree of depth mottle: mainly utilize the tretinoin in component to be effective ingredient, play the obstinate pigmentation improving drug resistance, or the effect of pigmentation after inflammation (i.e. pox print);
3, repairing skin tissue, minimizing wrinkle generate: mainly utilize the tretinoin in component, glucosamine hydrochloride or 2-Acetamido-2-deoxy-D-glucose for effective ingredient, play promotion skin renewal, dissolve cutin, to skin cuticular uneven (as acne scars) phenomenon, can calming down of shallow-layer be carried out, and the effect of wrinkle generation can be reduced;
4, moisturizing, nourishing, recovery skin elasticity: mainly utilize the glucosamine hydrochloride in component or 2-Acetamido-2-deoxy-D-glucose to be effective ingredient, play and promote dermal matrix metabolism, increase the hyaluronic generation of skin, promote moisture content of skin, improve skin resistance, make skin recover elastic effect, thus make the effect that the wrinkle generated shoals or eliminates;
5, present invention utilizes the synergism between tretinoin and glucosamine hydrochloride or 2-Acetamido-2-deoxy-D-glucose, significantly reduce tretinoin use amount, decrease the stimulation to skin, enhance the moisturizing of tretinoin and improve the effect of skin elasticity, and skin not easily produces untoward reaction and the toleration to medicine, avoids the dependency to skin care item.。
Therefore, each effective ingredient synergism above, resisting age of skin, crease-resistant, moisturizing moisturizing, skin nutrition can be played, desalination mottle, promotion skin renewal, repair skin cell tissue, thus improve skin, make skin recover smooth, fine and smooth, soft and smooth, whippy health status gradually.
In addition, by above-mentioned effective ingredient, add in O/W type cream base or gel-type vehicle, make the salubrious non-greasy of cream quality, skin effectively can be helped to absorb effective ingredient, promote effect of the present invention.Therefore the high-efficient compound medicine of a kind of anti aging effect provided by the invention, is applicable to the people of all ages and classes layer, and particularly, old women uses better.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in further detail.
The high-efficient compound medicine of anti aging effect of the present invention, the quality proportioning of its composition and each composition is as follows:
Tretinoin: 0.01-0.1%, glucosamine hydrochloride or 2-Acetamido-2-deoxy-D-glucose: 1-5%, all the other are cream base.
Wherein: tretinoin and glucosamine hydrochloride or 2-Acetamido-2-deoxy-D-glucose are effective ingredient.
Tretinoin adopts all-trans retinoic acid.Tretinoin is the metabolic intermediate of vitamin A in human body, has physiology and pharmacological activity widely.It has can induce epidermal hyperplasia, improves the tensile strength of skin; Inhibition test acne can generate, prevent and eliminate acne skin lesion; Reduce melanin to be formed, alleviate the effect of cutaneous pigmentation, can make that skin is smooth, fine and smooth, soft and smooth, high resilience, be play resisting age of skin, crease-resistant, antiinflammatory, desalinates the main component of the effect of mottle;
2-Acetamido-2-deoxy-D-glucose is the acylated derivatives of d-glucosamine, has and promotes dermal matrix metabolism, increases the hyaluronic generation of skin and suppresses epidermal pigment deposition, is the main component playing crease-resistant, moisturizing, whitening effect;
Found by our experiment, glucosamine hydrochloride equally as d-aminoglucose sugar derivatives is acting in skin similar with 2-Acetamido-2-deoxy-D-glucose effect, and difference is that 2-Acetamido-2-deoxy-D-glucose more easily imports skin than glucosamine hydrochloride.So we can substitute 2-Acetamido-2-deoxy-D-glucose as main component of the present invention with glucosamine hydrochloride.
Cream base selects O/W (oil-in-water) type cream base, i.e. vanishing cream substrate (vanishing cream base), and usual any one O/W type cream base in skin-protection product field all can use in the present invention.
Cream base is optional use gel-type vehicle also, and usual any one aqueous gel substrate in skin-protection product field all can use in the present invention.
Each composition of the present invention all can adopt commercially available existing finished product.
The high-efficient compound medicine of anti aging effect of the present invention, preferred version is:
Tretinoin: 0.01-0.1%,
Glucosamine hydrochloride or 2-Acetamido-2-deoxy-D-glucose: 1-5%,
Polyethylene Glycol, for dissolving tretinoin and glucosamine hydrochloride or 2-Acetamido-2-deoxy-D-glucose, mixes with the ratio of 600ml Polyethylene Glycol according to every 100mg effective ingredient,
All the other are cream base.
The dissolved matrix that the present invention adopts is Polyethylene Glycol (polyethylene glycol), Polyethylene Glycol can dissolve tretinoin, the degraded of tretinoin can be reduced again, increase its stability, dissolved matrix can adopt commercially available existing finished product, and in following embodiment, we are for PEG-4000 (PEG-400).
In the present invention, effective ingredient tretinoin and glucosamine hydrochloride or 2-Acetamido-2-deoxy-D-glucose have synergism, tretinoin use amount to 0.01% can be reduced, glucosamine hydrochloride or 2-Acetamido-2-deoxy-D-glucose use amount to 1%, both strengthened the moisturizing of tretinoin and improved the effect of skin elasticity, the untoward reaction of product can be reduced again, effective minimizing skin irritation, prevents the dependency to skin care item.
Preparation method of the present invention comprises the following steps:
First with a container tretinoin of proportional quantity and glucosamine hydrochloride or 2-Acetamido-2-deoxy-D-glucose be fully dissolved in the PEG-4000 of respective amount and obtain mixture, mix with the ratio of 600ml PEG-4000 according to every 100mg effective ingredient;
Again said mixture and cream base are mixed, and stir 30 seconds by ultra-fine homogenizer (5000rpm), obtain product.
Wherein, except PEG-4000, each constituent mass proportioning is as follows: tretinoin 0.01-0.1% (optium concentration 0.025%), and glucosamine hydrochloride or 2-Acetamido-2-deoxy-D-glucose 1-5% (optium concentration 2%), all the other are cream base.The combination of above-mentioned various effective ingredient can play good protection, health-care effect to skin, has obviously crease-resistant, antiinflammatory, and desalination mottle effect, has not yet to see the product identical with the present invention.
Be below embodiment (omitting the consumption of Polyethylene Glycol):
The high-efficient compound medicine of embodiment 1: every part anti aging effect, containing tretinoin: 0.01%, 2-Acetamido-2-deoxy-D-glucose 1%, all the other are cream base.
The high-efficient compound medicine of embodiment 2: every part anti aging effect, containing tretinoin: 0.025%, 2-Acetamido-2-deoxy-D-glucose 2%, all the other are cream base.This embodiment is optimum proportioning.
The high-efficient compound medicine of embodiment 3: every part anti aging effect, containing tretinoin: 0.05%, 2-Acetamido-2-deoxy-D-glucose 3%, all the other are cream base.
The high-efficient compound medicine of embodiment 4: every part anti aging effect, containing tretinoin: 0.075%, 2-Acetamido-2-deoxy-D-glucose 4%, all the other are cream base.
The high-efficient compound medicine of embodiment 5: every part anti aging effect, containing tretinoin: 0.1%, 2-Acetamido-2-deoxy-D-glucose 5%, all the other are cream base.
The high-efficient compound medicine of embodiment 6: every part anti aging effect, containing tretinoin: 0.01%, glucosamine hydrochloride 1%, all the other are cream base.
The high-efficient compound medicine of embodiment 7: every part anti aging effect, containing tretinoin: 0.025%, glucosamine hydrochloride 2%, all the other are cream base.This embodiment is optimum proportioning.
The high-efficient compound medicine of embodiment 8: every part anti aging effect, containing tretinoin: 0.05%, glucosamine hydrochloride 3%, all the other are cream base.
The high-efficient compound medicine of embodiment 9: every part anti aging effect, containing tretinoin: 0.075%, glucosamine hydrochloride 4%, all the other are cream base.
The high-efficient compound medicine of embodiment 10: every part anti aging effect, containing tretinoin: 0.1%, glucosamine hydrochloride 5%, all the other are cream base.
The high-efficient compound medicine of embodiment 11: every part anti aging effect, containing tretinoin: 0.1%, glucosamine hydrochloride or 2-Acetamido-2-deoxy-D-glucose 1%, all the other are cream base.
The high-efficient compound medicine of embodiment 12: every part anti aging effect, containing tretinoin: 0.09%, glucosamine hydrochloride or 2-Acetamido-2-deoxy-D-glucose 1.2%, all the other are cream base.
The high-efficient compound medicine of embodiment 13: every part anti aging effect, containing tretinoin: 0.06%, glucosamine hydrochloride or 2-Acetamido-2-deoxy-D-glucose 2.3%, all the other are cream base.
The high-efficient compound medicine of embodiment 14: every part anti aging effect, containing tretinoin: 0.035%, glucosamine hydrochloride or 2-Acetamido-2-deoxy-D-glucose 3.5%, all the other are cream base.
The high-efficient compound medicine of embodiment 15: every part anti aging effect, containing tretinoin: 0.011%, glucosamine hydrochloride or 2-Acetamido-2-deoxy-D-glucose 4.9%, all the other are cream base.
Result of use example:
Example 1: women, 46 years old, face had wrinkle, particularly around its lip, canthus, wrinkle is obvious, use the high-efficient compound medicine of the anti aging effect of joining by embodiment 1, consumption is 0.5 gram, uses before sleeping every day, once a day, after 3 months, wrinkle obviously shoals, and wrinkle quantity reduces, skin elasticity strengthens to some extent, bleach, and does not find untoward reaction and product dependency.
Example 2: women, 65 years old, facial wrinkles was obvious, particularly around its forehead, wrinkle is obvious, and use the high-efficient compound medicine of the anti aging effect of joining by embodiment 2, consumption is 0.5 gram, every day uses before sleeping, once a day, forehead part is applied in emphatically, after half a year, forehead wrinkle obviously shoals and quantity obviously reduces, skin elasticity and water content increase, and the colour of skin bleaches and brightens, and does not find untoward reaction and product dependency.
Example 3: women, 38 years old, facial more wrinkle, yellow complexion, there is freckle, use the high-efficient compound medicine of the anti aging effect of joining by embodiment 3, consumption is 0.5 gram, every day uses before sleeping, once a day, after 3 months, facial wrinkles obviously shoals, the colour of skin bleaches, and freckle is obviously thin out, does not find untoward reaction and product dependency.
Example 4: women, 42 years old, facial more wrinkle, there is obvious cyasma, use the high-efficient compound medicine of the anti aging effect of joining by embodiment 4, consumption is 0.5 gram, uses before sleeping every day, once a day, after 2 months, facial wrinkles obviously shoals, and mottle obviously disappears, the colour of skin bleaches, and does not find untoward reaction and dependency.
Example 5: women, 49 years old, the more wrinkle of forehead, lip, uses the high-efficient compound medicine of the anti aging effect of joining by embodiment 5, and consumption is 0.5 gram, every day uses before sleeping, once a day, after 5 months, forehead, lip wrinkle obviously shoal, skin elasticity is obviously improved, and does not find untoward reaction and dependency.
Example 6: women, 39 years old, face, cervical region had wrinkle, use the high-efficient compound medicine of the anti aging effect of joining by embodiment 6, consumption is 0.5 gram, every day uses before sleeping, once a day, after 1 month, wrinkle obviously shoals, wrinkle quantity reduces, and skin elasticity strengthens to some extent, does not find untoward reaction and product dependency.
Example 7: women, 62 years old, face, Neck wrinkles were obvious, and particularly around its cervical region, wrinkle is obvious, use the high-efficient compound medicine of the anti aging effect of joining by embodiment 7, consumption is 0.5 gram, uses, once a day before sleeping every day, be applied in neck portion emphatically, after 3 months, Neck wrinkles obviously shoals and quantity obviously reduces, and does not find untoward reaction and product dependency.
Example 8: women, 32 years old, face has a small amount of wrinkle, yellow complexion, has freckle, uses the high-efficient compound medicine of the anti aging effect of joining by embodiment 8, and consumption is 0.5 gram, every day uses before sleeping, once a day, after 1 month, wrinkle shoals, the colour of skin bleaches, freckle is obviously thin out, does not find untoward reaction and product dependency.
Example 9: women, 70 years old, face, the more wrinkle of cervical region, used the high-efficient compound medicine of the anti aging effect of joining by embodiment 9, consumption is 0.5 gram, uses, once a day, after half a year before sleeping every day, facial wrinkles, particularly Neck wrinkles obviously shoals, and does not find untoward reaction and dependency.
Example 10: women, 58 years old, have more wrinkle around eye, lip, use the high-efficient compound medicine of the anti aging effect of joining by embodiment 10, consumption is 0.5 gram, every day uses before sleeping, once a day, after 3 months, wrinkle obviously shoals, skin of face elasticity is obviously improved, and does not find untoward reaction and dependency.
Claims (9)
1. a high-efficient compound medicine for anti aging effect, is characterized in that, the quality proportioning of its composition and each composition is as follows:
Tretinoin: 0.01-0.1%, glucosamine hydrochloride or 2-Acetamido-2-deoxy-D-glucose: 1-5%, all the other are cream base.
2. the high-efficient compound medicine of anti aging effect as claimed in claim 1, is characterized in that:
Tretinoin: 0.025%, glucosamine hydrochloride: 2%, all the other are cream base, are optimum proportioning.
3. the high-efficient compound medicine of anti aging effect as claimed in claim 1, is characterized in that:
Tretinoin: 0.025%, 2-Acetamido-2-deoxy-D-glucose: 2%, all the other are cream base, are optimum proportioning.
4. the high-efficient compound medicine of the anti aging effect as described in claim 1 or 2 or 3, is characterized in that: tretinoin adopts all-trans retinoic acid.
5. the high-efficient compound medicine of the anti aging effect as described in claim 1 or 2 or 3, is characterized in that: cream base selects O/W type cream base or aqueous gel substrate.
6. the high-efficient compound medicine of anti aging effect as claimed in claim 4, is characterized in that: cream base selects O/W type cream base or aqueous gel substrate.
7., based on a preparation method for the high-efficient compound medicine of the anti aging effect of claim 1, it is characterized in that, comprise the following steps:
First with a container, the tretinoin of proportional quantity and glucosamine hydrochloride or 2-Acetamido-2-deoxy-D-glucose are fully dissolved in the Polyethylene Glycol of a great deal of;
Again said mixture and cream base are mixed, and stir 30 seconds by ultra-fine homogenizer, obtain product.
8. the preparation method of specific anti-wrinkle whitening cream as claimed in claim 7, is characterized in that:
Described tretinoin selects all-trans retinoic acid;
PEG-4000 selected by described Polyethylene Glycol;
Described cream base selects O/W type cream base or aqueous gel substrate;
Described effective ingredient is dissolved in the Polyethylene Glycol of a great deal of, mixes with the ratio of 600ml PEG-4000 according to every 100mg effective ingredient;
Described ultra-fine refiner is 5000rpm.
9. the high-efficient compound medicine of anti aging effect as claimed in claim 7 or 8, it is characterized in that: the use amount of tretinoin is low to moderate 0.01%, glucosamine hydrochloride or 2-Acetamido-2-deoxy-D-glucose use amount are low to moderate 1%.
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Application publication date: 20150506 |