CN104586531A - Rapid inhalation type intratracheal instillation medication system - Google Patents
Rapid inhalation type intratracheal instillation medication system Download PDFInfo
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- CN104586531A CN104586531A CN201510048160.8A CN201510048160A CN104586531A CN 104586531 A CN104586531 A CN 104586531A CN 201510048160 A CN201510048160 A CN 201510048160A CN 104586531 A CN104586531 A CN 104586531A
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- tracheal instillation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
- A61D7/04—Devices for anaesthetising animals by gases or vapours; Inhaling devices
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- Engineering & Computer Science (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention discloses a rapid inhalation type intratracheal instillation medication system. The medication system comprises an anesthesia device, a fixing device and a medication device, wherein the anesthesia device is used for performing anesthesia on a medicated object; the fixing device is used for fixing the medicated object after anesthesia; the medication device is used for instilling a medicament into a trachea of the medicated object. The rapid inhalation type intratracheal instillation medication system can be widely applied to pulmonary administration or toxicant exposure experiments and establishment of various disease models.
Description
Technical field
The present invention relates to a kind of drug-supplying system and method, more particularly, relate to a kind of suction-type tracheal instillation administration system and method fast.
Background technology
Respiratory tract exposure is an important route of exposure of the research fields such as occupational medicine, environmental medicine and toxicology, and inhalation exposure, respiratory tract administration have become the indispensable means of animal experiment study thus.1973, relevant scholar's reported first used the method for tracheal intubation successfully to instil particulate matter suspension to rat lung, and tracheal intubation also becomes the main experimental methods through Intratracheal administration or contamination gradually.Exposure formula tracheal instillation in the past needs to cut the skin of rat neck and muscle to expose trachea, again micro-sample injector is inserted trachea, thus the accuracy of experiment is guaranteed, but micro-sample injector of tip easily causes rats breathing road to damage and misery.Non-exposed formula tracheal instillation of today adopts the venous detaining needle of blunt or puncture needle to carry out intubate, although have Non-Invasive advantage, accuracy is but not as the former.Because these cannula needles often mate with ordinary syringe, and the degree of accuracy of ordinary syringe is not as micro-sample injector.In a word, non-exposed formula tracheal instillation apparatus and method are difficult to take into account non-invasive and accuracy.Research display, nasal cavity instils and also can reach the object of respiratory tract administration or contamination, but injection speed is slow, and the escaping gas narcotization being feature with quick-anaesthesia rapid recovery can not meet its requirement.
Summary of the invention
The object of the invention is some and certain problem for existing in prior art, a kind of suction-type tracheal instillation administration system and method is fast provided.
According to a first aspect of the invention, provide a kind of suction-type tracheal instillation administration system fast, it comprises:
Anesthesia outfit, is used for administration object to anaesthetize;
Fixture, is used for being fixed postanesthetic administration object; And
Doser, the intratracheal instillation medicine be used for administration object.
Under preferable case, wherein anesthesia outfit comprises:
Remote operated vehicle, is provided with carrier, and remote operated vehicle is used for delivering administration object;
Two-part anesthesia cabin, comprise front deck and rear deck, front deck is provided with front door, and rear deck is provided with rear door, is sealably connected between front deck and rear deck by rear door; Wherein rear deck is used for holding volatile anesthetic; And
Remote controller, can control remote operated vehicle and automatically pass in and out front deck and rear deck by front door and rear door.
More preferably, in situation, wherein front deck is connected with vacuum extractor and defecator.
More preferably, in situation, wherein front door and rear door are all automatic remote control door.
Under preferable case, wherein fixture comprises workbench and fixing tether on the table, and workbench has vertical table top, the dentition of visiting of postanesthetic administration object can be lived, administration object is naturally drooped along the vertical table top of workbench by tether.More preferably in situation, fixture also comprises clamper, and clamper is used for clamping and pulls out the tongue of administration object.Again under preferable case, wherein clamper one end is fixed on the vertical table top of workbench.
Under preferable case, wherein doser comprises liquid-transfering gun.
Under preferable case, wherein administration object is rat or mice.
According to a second aspect of the invention, a kind of suction-type tracheal instillation administration method is fast provided, comprises step:
(1) administration object is put into the anesthesia cabin that volatile anesthetic is housed, when administration object fall down motionless, breathe dark shape of seemingly sleeping soundly slowly, anesthesia completes;
(2) tangle front tooth on administration object with tether, make it naturally hang on the table, clamp with clamper and pull out the tongue of administration object;
(3) draw drip liquid with liquid-transfering gun, drip liquid is injected administration object mouth;
(4) gently pinching the nasal cavity about 5 seconds of administration object with have gentle hands, making it initiatively drip liquid be sucked pulmonary by breathing, if hear moist rale, then illustrate and instil successfully.
Quick suction-type tracheal instillation system and method for the present invention has the plurality of advantages such as cost is low, easy to operate, noinvasive efficient, environmental friendliness, can be widely applied to the foundation of respiratory tract administration or exposure experiment and various disease model.
Accompanying drawing explanation
Fig. 1 is the schematic diagram of the anesthesia outfit of drug-supplying system of the present invention; And
Fig. 2 is the schematic diagram of the fixture of drug-supplying system of the present invention.
Detailed description of the invention
Quick suction-type tracheal instillation administration system and method for the present invention is described in detail below in conjunction with accompanying drawing.It will be appreciated by those skilled in the art that embodiment described below is only to exemplary illustration of the present invention, but not for making any restriction to it.
According to quick suction-type tracheal instillation administration system (device) of the present invention, mainly comprise: anesthesia outfit, fixture and doser.Wherein, anesthesia outfit is used for administration object to anaesthetize; Fixture is used for being fixed postanesthetic administration object; Doser is used for the intratracheal instillation medicine to administration object.Wherein administration object can be any rodent.
See Fig. 1, in one particular embodiment of the present invention, anesthesia outfit comprises: remote operated vehicle 5, two-part anesthesia cabin and remote controller (not shown).Remote operated vehicle 5 is provided with carrier, is used for delivery administration object 6, and carrier is generally cage, and the suction-type of administration object 6 can be facilitated to anaesthetize, again can Real Time Observation to the state of administration object 6.Two-part anesthesia cabin comprises front deck 3 and rear deck 4, and front deck 3 is provided with front door 1, has hermetically-sealed construction between front door 1 and front deck 3; Rear deck 4 is provided with rear door 2, also has hermetically-sealed construction between rear door 2 and rear deck 4; Sealably connected by rear door 2 between front deck 3 and rear deck 4.When front door 1 and rear door 2 are closed, front deck 3 and rear deck 4 can each self-forming and extraneous air-tightness be closed.Rear deck 4 is used for holding volatile anesthetic, thus carry out quick suction-type anesthesia to by administration object 6, volatile anesthetic can be ether or isoflurane, can carry out quick-anaesthesia and rapid recovery, and can not produce grievous injury to administration object 6 to administration object 6.Remote controller can control remote operated vehicle 5 by front door 1 and rear door 2 turnover front deck 3 and rear deck 4 automatically.Front deck 3 and rear deck 4 have transparent material (such as inorganic or lucite) to make usually, thus from the outside can situation in Real Time Observation cabin, facilitate remote manipulation.Above-mentioned anesthesia outfit is not only applicable to drug-supplying system of the present invention, goes for other experimental systems yet.
When remote operated vehicle 5 passes in and out rear deck 4 from front deck 3, volatile anesthetic in rear deck 4 has sub-fraction anesthetis and evaporate in front deck 3 by rear door 2, therefore in certain embodiments of the present invention, front deck 3 is connected with vacuum extractor and defecator (not shown), thus evacuation and filtration treatment are carried out to the anesthetis evaporate in front deck 3, thus can not pollute indoor environment and operator.Wherein, front deck 3 is also provided with inlet valve (not shown), after evacuation completes, by inlet valve, front deck 3 is inflated, after being inflated to atmospheric pressure, front door 1 can be opened, make remote operated vehicle 5 roll front deck 3 away from.
In certain embodiments of the present invention, front door 1 and rear door 2 can be automatic remote control door, and its controller can be integrated on the remote controller of remote operated vehicle 5, thus automatically can be controlled the opening and closing of front door 1 and rear door 2 by remote controller.The principle of automatic remote control door and remote controller and structure are all known by those skilled in the art, omit it further describe at this.
See Fig. 2, the tether 8 that fixture in the present invention comprises workbench (frame) 9 and is fixed on workbench 9, workbench 9 has vertical table top, the dentition of visiting of postanesthetic administration object 6 can be lived by tether 8, administration object 6 is naturally drooped along the vertical table top of workbench 9.Fixture can also comprise clamper 7, and clamper 7 is used for clamping and pulls out the tongue of administration object 6.One end of clamper 7 can be fixed on the vertical table top of workbench 9.Doser is used for instiling medicine in the oral cavity of administration object 6, and doser can be liquid-transfering gun, and liquid-transfering gun has higher administration precision relative to syringe.
Take mice as administration object below, specifically describe quick suction-type tracheal instillation administration method of the present invention.
Quick suction-type tracheal instillation administration method of the present invention comprises following:
(1) mice is put into the anesthesia outfit that volatile anesthetic is housed, when mice fall down motionless, breathe dark shape of seemingly sleeping soundly slowly, anesthesia completes;
(2) tangle the upper front tooth of mice with tether, make it naturally hang on the table, clamp with clamper and pull out the tongue of mice;
(3) draw drip liquid with liquid-transfering gun, drip liquid is injected mice mouth;
(4) gently pinching the nasal cavity about 5 seconds of mice with have gentle hands, making it initiatively drip liquid be sucked pulmonary by breathing, if hear moist rale, then illustrate and instil successfully.
Wherein, the anesthesia outfit in above-mentioned steps (1) preferably adopts above see the anesthesia outfit described by Fig. 1, and concrete operation step is: first mice 6 is put into remote operated vehicle 5.Open front door 1, control remote operated vehicle 5 and enter front deck 3.Close front door 1, open rear door 2.Control remote operated vehicle 5 and enter rear deck 4, close rear door 2 rapidly.After mice 6 has been anaesthetized in rear deck 4, open rear door 2.Control remote operated vehicle 5 and enter front deck 3, close rear door 2 rapidly.Evacuation is carried out to front deck 3, a small amount of volatile anesthetic entered in front deck 3 is processed.After the vacuum in front deck 3 reaches setting value, stop evacuation.Open inlet valve, make front deck 3 recover normal pressure.Open front door 1, control remote operated vehicle 5 and roll front deck 3 away from, anesthesia procedure completes.
Wherein, above-mentioned steps (1) and (2) spended time relatively long, therefore can have been come by paraprofessional personnel, step (3) and (4) spended time relatively short, and it is higher to administration required precision, therefore can have been come by experienced professional, the time can either saving professional like this can ensure administration success rate again.
For 12 mices, medication of the present invention is adopted to carry out administration instillation.After having instiled, mice comparatively fast can recover normal condition, and have no adverse effects to the diet of mice and other activity, success rate is 100%.
By the contrast with other respiratory tract administrations or contamination device, the summary of benefits of quick suction-type tracheal instillation administration system and method for the present invention is as follows:
(1) system cost is low, economical rationality.(2) simple to operate, without the need to intubate, animal hangs naturally, and the misery decreasing animal, with uncomfortable, easily grasped, promoted.(3) adopt nhalant anesthesia, expend time in short, and easily regulate depth of anesthesia and comparatively fast stop anesthesia.After instillation, animal revives very soon, does not affect normal physiological activity.(4) instil effective, success rate is high.(5) anesthesia procedure automatic-sealed carries out, and can not impact operator and indoor environment.
In sum, quick suction-type tracheal instillation system and method for the present invention has the plurality of advantages such as cost is low, easy to operate, noinvasive efficient, environmental friendliness, can be widely applied to the foundation of respiratory tract administration or exposure experiment and various disease model.
Claims (10)
1. a quick suction-type tracheal instillation administration system, comprising:
Anesthesia outfit, is used for administration object to anaesthetize;
Fixture, is used for being fixed postanesthetic administration object; And
Doser, the intratracheal instillation medicine be used for administration object.
2. quick suction-type tracheal instillation administration system according to claim 1, wherein anesthesia outfit comprises:
Remote operated vehicle, is provided with carrier, and remote operated vehicle is used for delivering administration object;
Two-part anesthesia cabin, comprise front deck and rear deck, front deck is provided with front door, and rear deck is provided with rear door, is sealably connected between front deck and rear deck by rear door; Wherein rear deck is used for holding volatile anesthetic; And
Remote controller, can control remote operated vehicle and automatically pass in and out front deck and rear deck by front door and rear door.
3. quick suction-type tracheal instillation administration system according to claim 2, wherein front deck is connected with vacuum extractor and defecator.
4. quick suction-type tracheal instillation administration system according to claim 2, wherein front door and rear door are all automatic remote control door.
5. quick suction-type tracheal instillation administration system according to claim 1, wherein fixture comprises workbench and fixing tether on the table, workbench has vertical table top, the dentition of visiting of postanesthetic administration object can be lived by tether, administration object is naturally drooped along the vertical table top of workbench.
6. quick suction-type tracheal instillation administration system according to claim 5, fixture also comprises clamper, and clamper is used for clamping and pulls out the tongue of administration object.
7. quick suction-type tracheal instillation administration system according to claim 6, wherein clamper one end is fixed on the vertical table top of workbench.
8. quick suction-type tracheal instillation administration system according to claim 1, wherein doser comprises liquid-transfering gun.
9., according to the arbitrary described quick suction-type tracheal instillation administration system of claim 1-8, wherein administration object is rat or mice.
10. a quick suction-type tracheal instillation administration method, comprises step:
(1) administration object is put into the anesthesia cabin that volatile anesthetic is housed, when administration object fall down motionless, breathe dark shape of seemingly sleeping soundly slowly, anesthesia completes;
(2) tangle front tooth on administration object with tether, make it naturally hang on the table, clamp with clamper and pull out the tongue of administration object;
(3) draw drip liquid with liquid-transfering gun, drip liquid is injected administration object mouth;
(4) gently pinching the nasal cavity about 5 seconds of administration object with have gentle hands, making it initiatively drip liquid be sucked pulmonary by breathing, if hear moist rale, then illustrate and instil successfully.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510048160.8A CN104586531B (en) | 2015-01-30 | 2015-01-30 | Rapid inhalation type intratracheal instillation medication system |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510048160.8A CN104586531B (en) | 2015-01-30 | 2015-01-30 | Rapid inhalation type intratracheal instillation medication system |
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| CN104586531A true CN104586531A (en) | 2015-05-06 |
| CN104586531B CN104586531B (en) | 2017-02-22 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201510048160.8A Expired - Fee Related CN104586531B (en) | 2015-01-30 | 2015-01-30 | Rapid inhalation type intratracheal instillation medication system |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107174370A (en) * | 2017-07-05 | 2017-09-19 | 海南医学院 | A kind of experimental rat holder for suction-type tracheal instillation |
| CN110269040A (en) * | 2019-05-28 | 2019-09-24 | 军事科学院军事医学研究院环境医学与作业医学研究所 | A kind of method for building up of particulate matter breath exposure neurotoxicity rat model |
| CN111281598A (en) * | 2020-03-05 | 2020-06-16 | 纳菲(深圳)制药科技有限公司 | Anesthesia control system and method |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6352076B1 (en) * | 1999-07-01 | 2002-03-05 | Larry G. French | Anesthesia induction chamber for small animals |
| FR2854542A1 (en) * | 2003-05-07 | 2004-11-12 | Envt Toulouse | PROCESS AND INSTALLATION FOR ENCOURAGING ANIMALS USING NARCOSIS GAS |
| US20070028918A1 (en) * | 2005-08-08 | 2007-02-08 | Kei Tsuyuki | Anesthetizing chamber and microscope apparatus |
| CN202342230U (en) * | 2011-12-13 | 2012-07-25 | 中国人民解放军第三军医大学第二附属医院 | Mouse atomization box |
| CN203970609U (en) * | 2014-08-04 | 2014-12-03 | 天津中医药大学第二附属医院 | Doser in a kind of rat trachea |
-
2015
- 2015-01-30 CN CN201510048160.8A patent/CN104586531B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6352076B1 (en) * | 1999-07-01 | 2002-03-05 | Larry G. French | Anesthesia induction chamber for small animals |
| FR2854542A1 (en) * | 2003-05-07 | 2004-11-12 | Envt Toulouse | PROCESS AND INSTALLATION FOR ENCOURAGING ANIMALS USING NARCOSIS GAS |
| US20070028918A1 (en) * | 2005-08-08 | 2007-02-08 | Kei Tsuyuki | Anesthetizing chamber and microscope apparatus |
| CN202342230U (en) * | 2011-12-13 | 2012-07-25 | 中国人民解放军第三军医大学第二附属医院 | Mouse atomization box |
| CN203970609U (en) * | 2014-08-04 | 2014-12-03 | 天津中医药大学第二附属医院 | Doser in a kind of rat trachea |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107174370A (en) * | 2017-07-05 | 2017-09-19 | 海南医学院 | A kind of experimental rat holder for suction-type tracheal instillation |
| CN110269040A (en) * | 2019-05-28 | 2019-09-24 | 军事科学院军事医学研究院环境医学与作业医学研究所 | A kind of method for building up of particulate matter breath exposure neurotoxicity rat model |
| CN111281598A (en) * | 2020-03-05 | 2020-06-16 | 纳菲(深圳)制药科技有限公司 | Anesthesia control system and method |
| CN111281598B (en) * | 2020-03-05 | 2023-12-08 | 纳菲(深圳)制药科技有限公司 | Anesthesia control system and method |
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| CN104586531B (en) | 2017-02-22 |
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Granted publication date: 20170222 Termination date: 20180130 |