CN104557793B - 一种卡非佐米中间体的合成方法及其中间体 - Google Patents
一种卡非佐米中间体的合成方法及其中间体 Download PDFInfo
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- CN104557793B CN104557793B CN201510009149.0A CN201510009149A CN104557793B CN 104557793 B CN104557793 B CN 104557793B CN 201510009149 A CN201510009149 A CN 201510009149A CN 104557793 B CN104557793 B CN 104557793B
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- compound
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- carfilzomib
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- 0 CC(C)C[C@@](C(O)=O)N* Chemical compound CC(C)C[C@@](C(O)=O)N* 0.000 description 4
- BPPIGXCZEVQGNW-SECBINFHSA-N CC(C)CC(C([C@]1(C)OC1)=O)=N Chemical compound CC(C)CC(C([C@]1(C)OC1)=O)=N BPPIGXCZEVQGNW-SECBINFHSA-N 0.000 description 1
- DDMPMIMTLBGEHT-IINYFYTJSA-N CC(C)C[C@@H](C([C@]1(C)OC1)=O)NC(OC(C)(C)C)=O Chemical compound CC(C)C[C@@H](C([C@]1(C)OC1)=O)NC(OC(C)(C)C)=O DDMPMIMTLBGEHT-IINYFYTJSA-N 0.000 description 1
- SQGZZBDKNZTJRM-ZGTCLIOFSA-N CC(C)C[C@@H](CCC(C)CO)NC(OC(C)(C)C)=O Chemical compound CC(C)C[C@@H](CCC(C)CO)NC(OC(C)(C)C)=O SQGZZBDKNZTJRM-ZGTCLIOFSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D301/00—Preparation of oxiranes
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Abstract
Description
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201510009149.0A CN104557793B (zh) | 2015-01-08 | 2015-01-08 | 一种卡非佐米中间体的合成方法及其中间体 |
Applications Claiming Priority (1)
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CN201510009149.0A CN104557793B (zh) | 2015-01-08 | 2015-01-08 | 一种卡非佐米中间体的合成方法及其中间体 |
Publications (2)
Publication Number | Publication Date |
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CN104557793A CN104557793A (zh) | 2015-04-29 |
CN104557793B true CN104557793B (zh) | 2016-06-08 |
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Family Applications (1)
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CN201510009149.0A Active CN104557793B (zh) | 2015-01-08 | 2015-01-08 | 一种卡非佐米中间体的合成方法及其中间体 |
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CN (1) | CN104557793B (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3297678B1 (en) | 2015-05-21 | 2021-07-07 | Laurus Labs Limited | An improved processes for the preparation of carfilzomib or pharmaceutically acceptable salts thereof |
CN105294501B (zh) * | 2015-08-21 | 2017-09-29 | 上海应用技术学院 | 一种卡非佐米中间体化合物的制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014018807A1 (en) * | 2012-07-26 | 2014-01-30 | Centrax International, Inc. | Peptide epoxyketone compounds |
CN104086624B (zh) * | 2014-03-21 | 2017-01-18 | 河南海汇药物研究有限公司 | 一种卡非佐米的制备方法 |
CN103936828A (zh) * | 2014-05-12 | 2014-07-23 | 苏州科耐尔医药科技有限公司 | 卡非佐米中间体及卡非佐米的制备方法 |
CN104230857A (zh) * | 2014-08-19 | 2014-12-24 | 上海皓元生物医药科技有限公司 | 卡非佐米(Carfilzomib)的中间体化合物的制备方法及其中间体化合物 |
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2015
- 2015-01-08 CN CN201510009149.0A patent/CN104557793B/zh active Active
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CN104557793A (zh) | 2015-04-29 |
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Effective date of registration: 20170224 Address after: Xinghu Street Industrial Park of Suzhou city in Jiangsu province 215000 No. 218 bio nano technology park A6-404 unit Patentee after: Suzhou Su Wangsen Biological Medicine Technology Co Ltd Address before: 215123 Dongping street, Chongwen Industrial Park, Jiangsu, No. 286, No. Patentee before: Suzhou Qi Liyuan Pharmaceutical Technology Co., Ltd |
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Effective date of registration: 20190815 Address after: 215000 9th Floor, Building A, 108 Yuxin Road, Suzhou Industrial Park, Jiangsu Province Patentee after: Suzhou New Medicine Basket Biomedical Technology Co., Ltd. Address before: Xinghu Street Industrial Park of Suzhou city in Jiangsu province 215000 No. 218 bio nano technology park A6-404 unit Patentee before: Suzhou Su Wangsen Biological Medicine Technology Co Ltd |
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Address after: 9 / F, building a, 108 Yuxin Road, Suzhou Industrial Park, 215000 Jiangsu Province Patentee after: Suzhou Zhongke new drug basket Biomedical Technology Co.,Ltd. Address before: 9 / F, building a, 108 Yuxin Road, Suzhou Industrial Park, 215000 Jiangsu Province Patentee before: Suzhou New Medicine Basket Biomedical Technology Co.,Ltd. |