CN104547822A - Traditional Chinese medicinal composition for treating child enuresis and preparation method of preparations thereof - Google Patents
Traditional Chinese medicinal composition for treating child enuresis and preparation method of preparations thereof Download PDFInfo
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- CN104547822A CN104547822A CN201310498757.3A CN201310498757A CN104547822A CN 104547822 A CN104547822 A CN 104547822A CN 201310498757 A CN201310498757 A CN 201310498757A CN 104547822 A CN104547822 A CN 104547822A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/40—Cornaceae (Dogwood family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/487—Psoralea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9062—Alpinia, e.g. red ginger or galangal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention relates to a traditional Chinese medicinal composition for treating child enuresis and a preparation method of preparations thereof. The traditional Chinese medicinal composition comprises the following raw components: 5-15 parts of fructus alpiniae oxyphyllae, 5-15 parts of ootheca mantidis, 5-15 parts of fructus psoraleae, 10-20 parts of cuscuta chinensis, 6-10 parts of combined spicebush root, 10-20 parts of radix rehmanniae preparata, 10-20 parts of Chinese yam, 10-20 parts of dogwood and 10-20 parts of ossa draconis. The preparation method comprises the following steps: grinding the ossa draconis into fine powder, mixing the rest herbs, adding water for decocting twice, filtering, combining filtrates, concentrating till 1/ 2 of the volume of the filtrate to obtain a concentrated solution, concentrating till a thick extract with the relative density of 1.20-1.24 (measured at 80 DEG C), uniformly mixing with fine powder, transferring to a drying oven, drying water, adding auxiliary materials, and preparing into powder, capsules, tablets, granules or water pills.
Description
Technical field
The present invention relates to and be a kind ofly used for the treatment of the Chinese medicine composition of infantile enuresis and the preparation method of preparation thereof, belong to tcm field.
Background technology:
Infantile enuresis refers to that the children's of more than 5 years old can not Autonomous Control urinate, middle incontinence of urine of often sleeping, a kind of disease that rear of waking up is felt.Clinically be divided into primary enuresis and secondary enuresis two kinds, the former refers to the lasting or lasting enuresis, and the period controlling therebetween to urinate was never greater than 1 year; The latter refers to that children's controls to urinate at least 1 year, but continue after there is the enuresis again.Infantile enuresis great majority belong to functional.Its symptom and daytime fatigue degree, home environment, relevant to factors such as the adaptabilities of new environment.Urinate if the child of more than 5 years old or 5 years old is unconscious after repeatedly there is sleep, reach weekly more than 2 times and continue at least 6 months, then without this phenomenon under waking state, then exception should be regarded as, be referred to as constitutional nocturnal enuresis disease clinically, enuresis is not a kind of disease, but a symptom caused by many reasons, its factor occurred comprises heredity, psychology and society factor, sleep state, bladder function capacity etc.
The enuresis traditional Chinese medical science thinks children's's physical weakness, congenital deficiency of kidney-QI, deficiency-cold in the urinary bladder, gasification dereliction of duty, regulating fluid apssage malfunction and the enuresis occurs.Deficiency of both the splenic and pulmonary QI, lung is returned in spleen Tianjin of can not faling apart, and the deficiency of the lung can not regulating fluid apssage, and bladder loses binding function, and the enuresis occurs.Also have due to thoughtless to children's, it is improper to train, little childhood multiplex diaper, have urine to urinate whenever and wherever possible, affect with the passage of time bladder storage storage, affect bladder urinary system react formation, affect the formation of bladder pattern, this is also one of enuresis reason.In addition, also have and urinate not in time because suppressing urine, block up functioning of bladder, staying for a long time of urine is raw damp and hot, and damp and hot visitor, in bladder, also can cause the enuresis, especially 8-9 year child more common.
Western medicine has at treatment primary disease: imipramine, this medicine can reduce enuresis nocturna, and main mechanism, for alleviating Depth of sleep, makes enuresis child can aware the overflow of bladder.Acetic acid removes amine vassopressin: the neurohypophyseal hormone of synthesis, is mainly used in the enuresis child because vasopressin lacks.But all Western medicine application side effect are very large, and application is by age limit.This disease for the treatment of by Chinese herbs has broad prospects, and feature is application theory of Chinese medical science compatibe drug, and for cause of disease onset, and curative effect certainly.
Summary of the invention
For the deficiencies in the prior art, the invention provides a kind of Chinese medicine composition for the treatment of infantile enuresis and preparation method thereof.
Technical scheme of the present invention is as follows:
Treat a Chinese medicine composition for infantile enuresis, be made up of the raw material of following weight portion: Fructus Alpiniae Oxyphyllae 5-15 part, Ootheca Mantidis 5-15 part, Fructus Psoraleae 5-15 part, Semen Cuscutae 10-20 part, Radix Linderae 6-10 part, Radix Rehmanniae Preparata 10-20 part, Rhizoma Dioscoreae 10-20 part, Fructus Corni 10-20 part, Os Draconis 10-20 part.
As above-mentioned technology case further preferably, described Chinese medicine composition is made up of the raw material of following weight portion:
Fructus Alpiniae Oxyphyllae 10 parts, Ootheca Mantidis 10 parts, Fructus Psoraleae 10 parts, Semen Cuscutae 15 parts, the Radix Linderae 8 parts, 15 parts, Radix Rehmanniae Preparata, Rhizoma Dioscoreae 15 parts, Fructus Corni 15 parts, Os Draconis 15 parts.
Described Chinese medicine composition pharmaceutical dosage form is: water decoction, powder, capsule, tablet, granule or watered pill.
According to the present invention, a kind of preparation method of Chinese medicinal composition preparation, comprises the following steps:
A, get each material composition in proportion, mixing, decocts with water 30 minutes, becomes water decoction.
B, by Os Draconis pulverize be developed into 100 object fine powders.
C, Fructus Alpiniae Oxyphyllae, Ootheca Mantidis, Fructus Psoraleae, Semen Cuscutae, the Radix Linderae, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni to be mixed together, to decoct with water twice, filter, merging filtrate, be concentrated into 1/2 of filtrate volume, obtain concentrated solution, be concentrated into the thick extractum of relative density 1.20 ~ 1.24 (80 DEG C record).
D, by shift-in baking oven after the thick extractum of above-mentioned steps c and the fine powder mix homogeneously of step b, 50-70 DEG C dry to moisture lower than 5%, add adjuvant and make powder, capsule, tablet, granule or watered pill.
In above raw material
Fructus Alpiniae Oxyphyllae function warming the spleen, warming the kidney, solid and gas, arresting seminal emission.Cure mainly cold air stomachache, invasion by pathogenic cold vomit and diarrhoea, many salivas, seminal emission, dribbling urination, night many urine.
Ootheca Mantidis is used for emission due to deficiency of the kidney, premature ejaculation, sexual impotence, nebulousurine, leukorrhagia.Control kidney qi weakness, essence is closed not solid, seminal emission lingering diarrhea person.
Fructus Psoraleae function reinforcing the kidney and supporting YANG.Cure mainly cold diarrhea of suffering from a deficiency of the kidney, the enuresis, spermatorrhea, frequent micturition, sexual impotence, chills and pain of the waist and kness, deficiency and coldness is breathed heavily and is coughed.External curing vitiligo.
The invigorating the liver and kidney of Semen Cuscutae function, beneficial marrow, improving eyesight.Cure mainly and control soreness of waist and knee joint, seminal emission, quench one's thirst, dripping urination, order is dark.
Radix Linderae function is pleasant, dissipating depression of QI, cold expelling, pain relieving.Cure mainly QI rising in reverse order chest and abdomen swelling and pain, dyspepsia does not disappear, and food is told in regurgitation, colic of cold type, beriberi, frequent micturition.
Radix Rehmanniae Preparata has nourishing yin effect of enriching blood, and can be used for blood deficiency and yellow complexion, dizzy, palpitation and insomnia, menoxenia, the diseases such as metrorrhagia, also can be used for hectic fever hectic fever due to YIN-deficiency, the night sweat of deficiency of kidney yin, passes out semen, quenches one's thirst.
Rhizoma Dioscoreae has strengthening the spleen and tonifying the lung, stomach reinforcing the kidney invigorating, benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, help the five internal organs, bone and muscle strengthening, long will are calmed the nerves, effect of life lengthening.Cure mainly that weakness of the spleen and stomach, lassitude, inappetence, chronic diarrhea and dysentery, insufficiency of lung-QI are dry, phlegm dyspnea cough, kidney qi loss, soreness of the waist and knees, lower limb flaccidity be weak, the red disease such as swollen, fat of frequent micturition of quenching one's thirst, seminal emission premature ejaculation, leukorrhagia nebulousurine, skin.
Fructus Corni effect liver and kidney tonifying, arresting seminal emission, reducing urination, hidroschesis, for sexual impotence, seminal emission, frequent micturition, sweating and woman in menstrual period too much, persistent vaginal bloody discharge, have a dizzy spell, the card such as blurring of vision.
Os Draconis
effecttranquillizing the mind by relieving convulsion, arresting sweating controlling nocturnal emission with astringent drugs, hemostasis astringing intestine to stop diarrhea, promoting tissue regeneration and ulcer healing.Control infantile convulsion demented, palpitation with a distress feeling is forgetful, insomnia and dreamful sleep, spontaneous sweating, and seminal emission stranguria with turbid discharge, tell nosebleed and have blood in stool, bleeding not during menses, dysentery proctoptosis, ulcer does not close up for a long time.
Infantile enuresis tcm causa morbi is lower first deficiency and coldness, deficiency of kidney-QI, can not replenishing vital QI with drugs of warm nature bladder, functioning of bladder functional disorder, closes and hides imbalance, can not keep within bounds water channel, in addition deficiency of both the splenic and pulmonary QI, the urinary bladder being out of control, then incontinence of urine or middle urine of sleeping are from going out; Or because of dampness-heat of the liver, compel in burning hot, can the enuresis be caused.Material therefor of the present invention is bought and is facilitated low price, and raw material each component proportion example is reasonable, action compensating, organic compatibility, Radix Rehmanniae Preparata, Fructus Corni liver and kidney tonifying, arresting seminal emission reducing urination, Fructus Alpiniae Oxyphyllae warms up spleen kidney, Gu urine, Ootheca Mantidis controlling nocturnal emission with astringent drugs is only lost, Fructus Psoraleae kidney warming and yang invigorating activating QI, Semen Cuscutae, Radix Linderae invigorating the liver and kidney, beneficial marrow, Chinese yam spleen-strengtheningporridge tonifying the lung, stomach reinforcing the kidney invigorating, benefit of reinforcing the kidney essence, Os Draconis controlling nocturnal emission with astringent drugs is calmed the nerves.
The present invention adopts above technical scheme, compared with prior art, has the following advantages: monarch of the present invention, minister, help, make respectively to execute its effect, and have medication few, instant effect, clinical observation confirms to have no side effect, and can reach the object of giving consideration to both the incidental and fundamental, therapeutic effect is good.Without the toxic and side effects of chemicals, can long-term taking.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described.
Embodiment 1: a kind of Chinese medicine composition being used for the treatment of infantile enuresis, this Chinese medicine comprises following raw material:
Fructus Alpiniae Oxyphyllae 10 parts, Ootheca Mantidis 10 parts, Fructus Psoraleae 10 parts, Semen Cuscutae 15 parts, the Radix Linderae 8 parts, 15 parts, Radix Rehmanniae Preparata, Rhizoma Dioscoreae 15 parts, Fructus Corni 15 parts, Os Draconis 15 parts.
Preparation method one, comprises the following steps:
A, get each material composition in proportion, mixing, decocts with water 30 minutes, becomes water decoction.
B, by Os Draconis pulverize be developed into 100 object fine powders.
C, Fructus Alpiniae Oxyphyllae, Ootheca Mantidis, Fructus Psoraleae, Semen Cuscutae, the Radix Linderae, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni to be mixed together, to decoct with water twice, filter, merging filtrate, be concentrated into 1/2 of filtrate volume, obtain concentrated solution, be concentrated into the thick extractum of relative density 1.20 ~ 1.24 (80 DEG C record).
D, by shift-in baking oven after the thick extractum of above-mentioned steps c and the fine powder mix homogeneously of step b, 50-70 DEG C dry to moisture lower than 5%, add adjuvant and make powder, capsule, tablet, granule or watered pill.
Embodiment 2: a kind of Chinese medicine composition being used for the treatment of infantile enuresis, this Chinese medicine comprises following raw material: Fructus Alpiniae Oxyphyllae 5 parts, Ootheca Mantidis 5 parts, Fructus Psoraleae 5 parts, Semen Cuscutae 10 parts, the Radix Linderae 6 parts, 10 parts, Radix Rehmanniae Preparata, Rhizoma Dioscoreae 10 parts, Fructus Corni 10 parts, Os Draconis 10 parts.
Preparation method is with embodiment 1.
Embodiment 3: a kind of Chinese medicine composition being used for the treatment of infantile enuresis, this Chinese medicine comprises following raw material: Fructus Alpiniae Oxyphyllae 15 parts, Ootheca Mantidis 15 parts, Fructus Psoraleae 15 parts, Semen Cuscutae 20 parts, the Radix Linderae 10 parts, 20 parts, Radix Rehmanniae Preparata, Rhizoma Dioscoreae 20 parts, Fructus Corni 20 parts, Os Draconis 20 parts.
Preparation method is with embodiment 1.
Contrast test:
Criterion of therapeutical effect; Curative effect determinate standard according to the treatment enuresis in " TCM Pediatrics disease Standardization of diagnosis and curative effect ": efficacy evaluation is cured: the not enuresis again after controlling.Take a turn for the better: enuresis number of times reduces, and can wake and urinate in sleep.Do not heal: the enuresis is unchanged.
Choose the patient of 300 examples, random selecting 300 example is as treatment group, other 100 examples as a control group, wherein 300 routine patients are divided into treatment group 1, treatment group 2 and treatment group 3,100 routine patients of each treatment group treatment random selecting, the decoction that treatment group 1 uses the embodiment of the present invention 1 to prepare is treated, and the decoction that treatment group 2 uses the embodiment of the present invention 2 to prepare is treated, and the decoction that treatment group 3 uses the embodiment of the present invention 3 to prepare is treated.Matched group adopts oral imipramine to treat.
Therapeutic outcome is as following table:
As can be seen from above tables of data, treatment group effective percentage cure rate is apparently higher than matched group, and the cure rate effective percentage for the treatment of group 1 is higher than all the other treatment groups 2 and treatment group 3, and treatment group 1 prescription is the most effective in sum.
Claims (4)
1. treat a Chinese medicine composition for infantile enuresis, it is characterized in that: be made up of the raw material of following weight portion: Fructus Alpiniae Oxyphyllae 5-15 part, Ootheca Mantidis 5-15 part, Fructus Psoraleae 5-15 part, Semen Cuscutae 10-20 part, Radix Linderae 6-10 part, Radix Rehmanniae Preparata 10-20 part, Rhizoma Dioscoreae 10-20 part, Fructus Corni 10-20 part, Os Draconis 10-20 part.
2. the Chinese medicine composition for the treatment of infantile enuresis as claimed in claim 1, is characterized in that: by following weight portion raw material make: Fructus Alpiniae Oxyphyllae 10 parts, Ootheca Mantidis 10 parts, Fructus Psoraleae 10 parts, Semen Cuscutae 15 parts, the Radix Linderae 8 parts, 15 parts, Radix Rehmanniae Preparata, Rhizoma Dioscoreae 15 parts, Fructus Corni 15 parts, Os Draconis 15 parts.
3. the Chinese medicine composition for the treatment of infantile enuresis as claimed in claim 1 or 2, is characterized in that: described pharmaceutical dosage form is: water decoction, powder, capsule, tablet, granule or watered pill.
4. a preparation method for the Chinese medicinal composition preparation of the treatment infantile enuresis described in claim 1 or 2, comprises the following steps:
A, get each material composition in proportion, mixing, decocts with water 30 minutes, becomes water decoction.
B, by Os Draconis pulverize be developed into 100 object fine powders.
C, Fructus Alpiniae Oxyphyllae, Ootheca Mantidis, Fructus Psoraleae, Semen Cuscutae, the Radix Linderae, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni to be mixed together, to decoct with water twice, filter, merging filtrate, be concentrated into 1/2 of filtrate volume, obtain concentrated solution, be concentrated into the thick extractum of relative density 1.20 ~ 1.24 (80 DEG C record).
D, by shift-in baking oven after the thick extractum of above-mentioned steps c and the fine powder mix homogeneously of step b, 50-70 DEG C dry to moisture lower than 5%, add adjuvant and make powder, capsule, tablet, granule or watered pill.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104958676A (en) * | 2015-08-02 | 2015-10-07 | 马丽 | Chinese medicinal composition for treating infantile enuresis |
| CN105148152A (en) * | 2015-09-25 | 2015-12-16 | 麻翠秋 | Foot bath lotion for treating infantile enuresis |
| CN106138947A (en) * | 2016-08-18 | 2016-11-23 | 汤明 | A kind of medicine treating heart kidney deficiency infantile enuresis and preparation method thereof |
| CN107029163A (en) * | 2017-05-02 | 2017-08-11 | 徐士魁 | It is a kind of to treat medicine of infantile enuresis and preparation method thereof |
| CN109876111A (en) * | 2019-04-19 | 2019-06-14 | 杨庆昌 | A kind of Chinese medicine preparation and preparation method thereof for treating the child bed-wetting enuresis |
-
2013
- 2013-10-23 CN CN201310498757.3A patent/CN104547822A/en not_active Withdrawn
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104958676A (en) * | 2015-08-02 | 2015-10-07 | 马丽 | Chinese medicinal composition for treating infantile enuresis |
| CN105148152A (en) * | 2015-09-25 | 2015-12-16 | 麻翠秋 | Foot bath lotion for treating infantile enuresis |
| CN106138947A (en) * | 2016-08-18 | 2016-11-23 | 汤明 | A kind of medicine treating heart kidney deficiency infantile enuresis and preparation method thereof |
| CN107029163A (en) * | 2017-05-02 | 2017-08-11 | 徐士魁 | It is a kind of to treat medicine of infantile enuresis and preparation method thereof |
| CN109876111A (en) * | 2019-04-19 | 2019-06-14 | 杨庆昌 | A kind of Chinese medicine preparation and preparation method thereof for treating the child bed-wetting enuresis |
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Application publication date: 20150429 |