CN104547721A

CN104547721A - Traditional Chinese medicine for treating cholecystitis

Info

Publication number: CN104547721A
Application number: CN201510060111.6A
Authority: CN
Inventors: 王昌荣; 刘爱桢
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-02-05
Filing date: 2015-02-05
Publication date: 2015-04-29

Abstract

The invention relates to the field of pharmaceutical formulations and in particular relates to a traditional Chinese medicine for treating cholecystitis. The traditional Chinese medicine is characterized by being prepared from the following raw material medicines in parts by weight: 77-87 parts of serrate rabdosia herb, 41-51 parts of nauclea officinalis, 25-35 parts of aeluropus littoralis, 33-43 parts of aculeate staff tree, 25-35 parts of glossy privet fruit, 18-28 parts of felwort, 21-31 parts of avicennia pricklyash root, 19-29 parts of Heterohairy Monkshood Root, 14-24 parts of garden burnet, 20-30 parts of akebiaquinata, 13-23 parts of dayflower, 16-26 parts of raspberry, 10-20 parts of equisetum pretense, 37-47 parts of sophora fruit, 24-34 parts of buerger raspberry root, 26-36 parts of abrus cantoniensis hance, 8-18 parts of fruit of princesplume ladysthumb and 6-16 parts of caulis bambusae in taeniam. The preparation method comprises the following steps: mixing the raw material medicines, soaking by using water, decocting, and removing the decoction dregs, thereby obtaining the filtrate. The traditional Chinese medicine disclosed by the invention is short in course of treatment, fast in effectiveness, safe and non-toxic, does not have any side effect, is exact in curative effect of treating cholecystitis, can be used for improving the symptoms and alleviate pain of patients and can be widely applied to clinical treatment of the cholecystitis.

Description

the Chinese medicine for the treatment of cholecystitis

Technical field

The present invention relates to a kind of Chinese patent medicine preparation, specifically a kind of Chinese medicine for the treatment of cholecystitis.

Background technology

As everyone knows, cholecystitis is a kind of common clinical, frequently-occurring disease, has that the course of disease is long, the feature of recurrent exerbation, and modern medicine thinks the many infection due to antibacterial and virus of cholecystitis, and obstruction of bile duct or pancreatic juice cause to multiple chemical factors such as biliary tract reflux.Along with people's living standard improves day by day, the change of dietary structure and the increase of job and life stress, the sickness rate of primary disease is in rising trend.Cholecystitis has become one of principal disease affecting human health.

Summary of the invention

Object of the present invention is exactly to overcome above-mentioned existing technical deficiency, provides a kind of Chinese medicine for the treatment of cholecystitis, short treating period instant effect, safe without toxic side effect, treatment cholecystitis determined curative effect, can symptom be improved, alleviate patient suffering, the clinical treatment of cholecystitis can be widely used in.

The technical scheme that the present invention solves the problems of the technologies described above employing is: a kind of Chinese medicine for the treatment of cholecystitis, it is characterized in that being made up of the crude drug of following weight portion, Herba Rabdosiae Lophanthoidis 77 ~ 87, Lignum et Radix Naucleae 41 ~ 51, Herba Aeluropi sinensis 25 ~ 35, Celastrus aceleatus Merr 33 ~ 43, Fructus Ligustri Lucidi 25 ~ 35, Radix Gentianae 18 ~ 28, Radix Zanthoxyli Avicennae 21 ~ 31, Radix Aconiti Heterotrichi 19 ~ 29, Radix Sanguisorbae 14 ~ 24, Caulis Akebiae 20 ~ 30, Herba Commelinae 13 ~ 23, Fructus Rubi 16 ~ 26, Equisetum pratense 10 ~ 20, the Fructus Sophorae 37 ~ 47, Radix rubi buergeri 24 ~ 34, Herba Abri 26 ~ 36, Fructus Polygoni Orientalis 8 ~ 18, Caulis Bambusae In Taenia 6 ~ 16, be soaked in water after above-mentioned raw materials medicine is mixed, to remove slag after decocting to obtain filtrate.

The invention has the beneficial effects as follows, short treating period instant effect, safe without toxic side effect, treatment cholecystitis determined curative effect, can improve symptom, alleviate patient suffering, can be widely used in the clinical treatment of cholecystitis.

Detailed description of the invention

Below in conjunction with embodiment, the invention will be further described:

Embodiment 1: the present embodiment adopts Herba Rabdosiae Lophanthoidis, Lignum et Radix Naucleae, Herba Aeluropi sinensis, Celastrus aceleatus Merr, Fructus Ligustri Lucidi, Radix Gentianae, Radix Zanthoxyli Avicennae, Radix Aconiti Heterotrichi, Radix Sanguisorbae, Caulis Akebiae, Herba Commelinae, Fructus Rubi, Equisetum pratense, the Fructus Sophorae, Radix rubi buergeri, Herba Abri, Fructus Polygoni Orientalis, Caulis Bambusae In Taenia to be that crude drug is prepared from.Its crude drug composition (weight portion) often takes as Herba Rabdosiae Lophanthoidis 82, Lignum et Radix Naucleae 46, Herba Aeluropi sinensis 30, Celastrus aceleatus Merr 38, Fructus Ligustri Lucidi 30, Radix Gentianae 23, Radix Zanthoxyli Avicennae 26, Radix Aconiti Heterotrichi 24, Radix Sanguisorbae 19, Caulis Akebiae 25, Herba Commelinae 18, Fructus Rubi 21, Equisetum pratense 15, the Fructus Sophorae 42, Radix rubi buergeri 29, Herba Abri 31, Fructus Polygoni Orientalis 13, Caulis Bambusae In Taenia 11.Get above-mentioned 18 kinds of crude drug, gross mass is 250g, at room temperature Chinese herbal medicine is added water to 900-1000ml, soak 4 hours, then boil slow fire with high heat and decoct to about 100-120 minute, remove slag to obtain filtrate about 200ml, medicinal residues add water 300-400ml again, decoct 30-40 minute, remove slag to obtain filtrate about 100ml, decocts medicine soup about 300ml for twice altogether.Every day, potion was oral at twice, each (medicine) being taken before meal about 150ml.

Herba Rabdosiae Lophanthoidis of the present invention has effect of clearing away heat-damp and promoting diuresis, jaundice eliminating damp eliminating, cool the blood dissipate blood stasis, is used for the treatment of acute icterohepatitis, acute cholecystitis; Lignum et Radix Naucleae can treat heat-clearing and toxic substances removing, reducing swelling and alleviating pain.Treating acute tonsillitis, pharyngolaryngitis, mastitis, enteritis, bacillary dysentery, urinary tract infection, cholecystitis; Herba Aeluropi sinensis has the function of clearing away heat and promoting diuresis.For icterohepatitis, the diseases such as gallbladder wing inflammation and cirrhotic ascites; Celastrus aceleatus Merr damp-clearing pain-relieving, damp eliminating function of gallbladder promoting, suppressing the hyperactive liver and subsiding YANG; Fructus Ligustri Lucidi is used for the poor vision of the hepatic and renal YIN deficiency, visual deterioration, early whitening of beard and hair, soreness of waist tinnitus and fever due to yin deficiency etc.; Radix Gentianae heat clearing and damp drying, eliminating pathogen in the liver is calmed the frightened.Jaundice due to damp-heat, urine leaching pain; Radix Zanthoxyli Avicennae controls laryngopharynx swelling and pain, general edema with yellowish skin, malaria, rheumatic ostalgia; Radix Aconiti Heterotrichi expelling wind and removing dampness, promoting blood circulation and stopping pain; The effects such as Radix Sanguisorbae has cooling blood for hemostasis, heat-clearing and toxic substances removing, trains clear yin nourishing, detumescence sore; Caulis Akebiae is used for stranguria, edema, vexed dark coloured urine, aphtha of the mouth and tongue, and amenorrhea breast is few, damp and hot arthralgia pain; The capable water of Herba Commelinae, heat clearing away, removing heat from blood, removing toxic substances.Harness the river swollen, beriberi, dysuria, flu, erysipelas, parotitis; Fructus Rubi the liver and the kidney tonifying, controlling nocturnal emission with astringent drugs reducing urination, improving eyesight; Equisetum pratense is invigorated blood circulation, diuresis, anthelmintic; Fructus Sophorae parasite killing removes wind, and improving eyesight is except hot tears, and between brains ambition, hot blast is unhappy, and dizziness due to wind pathogen is for falling; Radix rubi buergeri heat-clearing and toxic substances removing, promoting blood circulation and stopping pain.To treat for stomachache acid regurgitation, icterohepatitis; Herba Abri has dampness removing jaundice eliminating, heat-clearing and toxic substances removing, effect of dispersing the depressed liver-QI for alleviating pain; Fructus Polygoni Orientalis heat clearing away, softening the hard mass.For abdominal mass, the tuberculosis of cervical lymph nodes, diabetes; Caulis Bambusae In Taenia removing heat-phlegm, relieves restlessness and prevents vomiting.

The each raw material of the present invention also can the embodiment of part by weight mixing listed by according to the form below realize.Its processing technique is identical with embodiment 1.(unit: weight portion)

Embodiment	Herba Rabdosiae Lophanthoidis	Lignum et Radix Naucleae	Herba Aeluropi sinensis	Celastrus aceleatus Merr	Fructus Ligustri Lucidi	Radix Gentianae	Radix Zanthoxyli Avicennae	Radix Aconiti Heterotrichi	Radix Sanguisorbae	Caulis Akebiae	Herba Commelinae	Fructus Rubi	Equisetum pratense	The Fructus Sophorae	Radix rubi buergeri	Herba Abri	Fructus Polygoni Orientalis	Caulis Bambusae In Taenia
																			Two	77	51	25	43	25	28	21	29	14	30	13	26	10	47	24	36	8	16
Three	87	41	35	33	35	18	31	19	24	20	23	16	20	37	34	26	18	6
																			Four	80	46	31	38	30	26	22	21	16	26	18	18	19	37	28	30	16	14

The clinical trial carried out below in conjunction with my institute is described in further detail the present invention:

1 data and method

1.1 physical data

Select cholecystitis 90 example that the Gastroenterology dept.'s outpatient service of 2012-2013 hospital and in-patient department are gone to a doctor, all meet " new Chinese medicine guideline of clinical investigations " and determine diagnosis.Inclusive criteria: the patient meeting chronic cholecystitis diagnosis and Standards of Chinese Medical Syndrome Differentiation, can include test case in.Exclusion standard: (1) does not meet inclusive criteria; (2) discomforts such as the side of body rib distension pain of being brought out by the factor such as Drug or other diseases.(3) merge intentionally, the serious disease such as brain, lung, kidney.(4) gestation or women breast-feeding their children, those who are allergic to this drug.(5) severe cholecystitis: acute suppuration cholecystitis, acute gangrenous cholecystitis, acute obstructive suppurative cholangitis, the concurrent diffuse peritonitis person of perforation of gallbladder.(6) take other similar drugs person simultaneously.

Treatment group 60 example, come off 1 example, totally 59 example, male 31 example, women 28 example, 18-29 year 12 people, 30-49 year 28 people, 50-65 year 19 people, patient course of disease <1 10 people, 1-5 30 people, 5-10 19 people;

Matched group 30 example, come off 2 example, totally 28 example, wherein male 15 example, women 13 example, 18-29 year 5 people, 30-49 year 13 people, 50-65 year 10 people, patient course of disease <1 4 people, 1-5 14 people, 5-10 10 people.Three groups of case physical data (sex, age, the course of disease) comparing difference not statistically significants.

1.2 Therapeutic Method

Treatment group oral Chinese medicine composition one (preparing with reference to embodiment 1), every day, potion was oral at twice, each (medicine) being taken before meal about 150ml; The oral DANNING PIAN of matched group (being produced by Shanghai and xanthate industry), 5 tablets/time, every day three times.Treat 8 weeks.Period in a medicine avoids greasy, irritative food, work and rest rule.

1.3 observation index and method

1.3.1 clinical symptoms integral estimation: carry out a clinical symptoms integral estimation before treatment, once in a week rear.

1.3.2 lab index: hematuria stool routine, electrocardiogram, B ultrasonic and ALT, serum creatinine.Before treatment, once, rear every surrounding carries out ALT, serum creatinine inspection to contained item inspection, terminates rear check hematuria stool routine, electrocardiogram and B ultrasonic the course for the treatment of.B ultrasonic result before and after contrast therapy, observes the change of calculus size, gall-bladder wall thickness.

1.4 criterion of therapeutical effect

Formulate with reference to " new Chinese medicine clinical research principle ".Recovery from illness: after terminating the course for the treatment of, symptom and sign disappear, ultrasound diagnosis gallbladder volume and wall thickness normal; Effective: after terminating the course for the treatment of, symptom integral reduces 2 grades, and ultrasound diagnosis gallbladder volume and wall thickness obviously improve; Effective: after terminating the course for the treatment of, symptom integral reduces 1 grade, and ultrasound diagnosis gallbladder volume and wall thickness are improved; Invalid: not reach above-mentioned standard person, ultrasound diagnosis gallbladder volume still increases, wall thickness, crude.

1.5 statistical method

Adopt SPSS15.0 statistical software to carry out computational analysis, measurement data adopts t inspection, and enumeration data adopts X 2 test, and P<0.05 is that difference has statistical significance.

2 results

Clinical efficacy after 2.1 therapeutic evaluation treatment groups and treatment of control group is through statistical analysis, and the Different therapeutical effect of two groups has statistical significance (P<0.05), and treatment group is better than matched group (table 1).

Following table is the comparison [example (%)] of clinical efficacy

Group	Number of cases	Effective	Effectively	Invalid	Total effective rate (%)
						Treatment group	59	41（70.0）	15（24.8）	3（5.2）	94.8
Matched group	28	15（55.8）	7（23.6）	6（20.6）	79.4

2.2 untoward reaction: two groups all do not occur untoward reaction at treatments period.

Claims

1. treat the Chinese medicine of cholecystitis for one kind, it is characterized in that: be made up of the crude drug of following weight portion, Herba Rabdosiae Lophanthoidis 77 ~ 87, Lignum et Radix Naucleae 41 ~ 51, Herba Aeluropi sinensis 25 ~ 35, Celastrus aceleatus Merr 33 ~ 43, Fructus Ligustri Lucidi 25 ~ 35, Radix Gentianae 18 ~ 28, Radix Zanthoxyli Avicennae 21 ~ 31, Radix Aconiti Heterotrichi 19 ~ 29, Radix Sanguisorbae 14 ~ 24, Caulis Akebiae 20 ~ 30, Herba Commelinae 13 ~ 23, Fructus Rubi 16 ~ 26, Equisetum pratense 10 ~ 20, the Fructus Sophorae 37 ~ 47, Radix rubi buergeri 24 ~ 34, Herba Abri 26 ~ 36, Fructus Polygoni Orientalis 8 ~ 18, Caulis Bambusae In Taenia 6 ~ 16, be soaked in water after above-mentioned raw materials medicine is mixed, to remove slag after decocting to obtain filtrate.