CN104547529A - Traditional Chinese medicine for treating chloasma and application thereof - Google Patents
Traditional Chinese medicine for treating chloasma and application thereof Download PDFInfo
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- CN104547529A CN104547529A CN201510025077.9A CN201510025077A CN104547529A CN 104547529 A CN104547529 A CN 104547529A CN 201510025077 A CN201510025077 A CN 201510025077A CN 104547529 A CN104547529 A CN 104547529A
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Abstract
The invention discloses a traditional Chinese medicine for treating chloasma and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine is prepared from the following Chinese medicinal materials: climbing fig fruits, dwarf lilyturf tubers, smoothfruit ventilago roots or stems, indigofera stachyodes lindl., scarlet kadsura roots, figs, geum urbanum, sandhill tylophora roots, auricularia, mulberry fruits, Chinese redbud barks, brown granulated sugar and boat-fruited scaphium seeds. The traditional Chinese medicine disclosed by the invention is reasonable in combination of Chinese medicinal materials, has the efficacies of nourishing yin, tonifying the kidneys, promoting the circulation of blood, replenishing blood, dredging collaterals, dissipating stasis, lubricating the intestines and relaxing the bowels, and can be used for treating chloasma radically. The traditional Chinese medicine has the advantages of significant effect and high treatment rate, has no toxic or side effects and is safe.
Description
Technical field
The invention belongs to technical field of Chinese medicine, be specifically related to a kind of Chinese medicine for the treatment of chloasma.
Background technology
Chloasma has another name called chloasma hepaticum, is a kind of common posteriority hyperpigmentation dermatoses betiding face, betides Exposure to Sunlight position, and in Exposure to Sunlight postemphasis.Young and middle-aged women is common.The course of disease is chronic, without obvious subjective symptoms.The state of an illness has certain seasonality, and Xia Chongdong is light.Pigment is greater than more than 20% of self facial average optical density value along zone leveling optical density value.Be apt to occur in women, particularly the women of trimester of pregnancy, puerperal and oral contraceptive.Erythra symmetry distribution around face, volume, two cheeks, bridge of the nose both sides, lip, skin of chin, in refer to lid to coin size or in hand size, filbert or crineous in irregular shape sinks speckle, boundary is obvious or smudgy, can be fused into sheet.No conscious sympton, chronic process, Exposure to Sunlight postemphasis.A part is owing to can slowly disappear after point puerperium or inactive contraceptive.Discolor element or depigmenting preparations of the general external of western medicine chloasma is that in treatment epidermis, melanin increases, but can only control, and can not eradicate chloasma.Pathogenesis and dialectical: the traditional Chinese medical science is thought, deficiency of kidney yin, kidney water can not on hold, or stagnation of liver-QI is depressed, and liver is lost bar and reaches, and strongly fragrant heat-transformation of a specified duration, cloudy blood of burning, causes face qi-blood disharmony and fall ill.
Summary of the invention
The present invention through studying for many years, obtains a kind of Be very effective, safe without toxic side effect under the guide for method of differentiation of tcm, thoroughly can effect a radical cure the Chinese medicine of chloasma.
Technical scheme of the present invention is as follows:
Treat a Chinese medicine for chloasma, obtained by following weight parts Chinese crude drug: Fructus Fici Pumilae 20-22 part, Radix Ophiopogonis 23-25 part, Radix seu Caulis Verntilaginis Leiocarpae 28-30 part, Indigofera stachyoides Lindl. 30-32 part, Radix Kadsurae Coccineae 30-32 part, Fructus Fici Beecheyanae 21-23 part, the fragrant 10-12 part of bodhi, Radix Tylophorae arenicolae 9-11 part, Auricularia polytricha (Mout) Sacc. 13-15 part, Fructus Mori 12-14 part, Cortex cercis chinensis 7-9 part, brown sugar (Saccharum Sinensis Roxb.) 9-11 part, Semen Sterculiae Lychnophorae 4-6 part.
Further preferably, the Chinese medicine of above-mentioned treatment chloasma, is obtained by following weight parts Chinese crude drug: Fructus Fici Pumilae 21 parts, Radix Ophiopogonis 24 parts, Radix seu Caulis Verntilaginis Leiocarpae 29 parts, Indigofera stachyoides Lindl. 31 parts, Radix Kadsurae Coccineae 31 parts, Fructus Fici Beecheyanae 22 parts, fragrant 11 parts of bodhi, Radix Tylophorae arenicolae 10 parts, Auricularia polytricha (Mout) Sacc. 14 parts, 13 parts, Fructus Mori, Cortex cercis chinensis 8 parts, brown sugar (Saccharum Sinensis Roxb.) 10 parts, Semen Sterculiae Lychnophorae 5 parts.
According to Chinese medicine Historical Data Data About, pharmacologically active and the function of above-mentioned each medical material cure mainly as follows:
Fructus Fici Pumilae, [nature and flavor] sweet in the mouth, property are flat.[function cures mainly] tonifying the kidney to consolidate the essence; Clearing away heat-damp and promoting diuresis; Promoting blood circulation to restore menstrual flow; Lactogenic; Separate detumescence.
Radix Ophiopogonis: [nature and flavor] are sweet; Micro-hardship; Cold.[function cures mainly] nourishing YIN and moistening the lung; Reinforcing stomach reg fluid; Clear away heart-fire relieving restlessness.Main dryness of the lung dry cough; Lung abscess; Deficiency of YIN chronic cough; Tianjin wound is thirsty; Quench one's thirst; Vexed insomnia; Have sore throat; Dryness of the intestine constipation; Heat in blood tells nosebleed.
Radix seu Caulis Verntilaginis Leiocarpae, [nature and flavor] are sweet, temperature.[function cures mainly] benefiting vital QI and blood, dispelling, collateral-activating.Control deficiency of both QI and blood, rheumatalgia, traumatic injury.Guangzhou army " conventional Chinese herbal medicine handbook ": " rich in nutrition, relaxing muscles and tendons and activating QI and blood in the collateral.Control deficiency of both QI and blood, menoxenia, bones and muscles pain due to rheumatism, numb limbs and tense tendons, traumatic injury.”
Indigofera stachyoides Lindl., [nature and flavor] micro-hardship, puckery, temperature.[function cures mainly] promoting blood circulation and stopping pain, relaxing muscles and tendons and activating QI and blood in the collateral, enriching yin and nourishing kidney, hemostasis by invigorating QI.Cure mainly metrorrhagia, traumatic injury and rheumatism, liver cirrhosis, infantile malnutrition, dysentery; Ulcer is QI and blood deficiency with the passing of time.
Radix Kadsurae Coccineae, [function cures mainly] circulation of qi promoting, invigorates blood circulation, dissipating blood stasis, pain relieving.Control acute gastroenteritis, chronic gastritis, gastric and duodenal ulcers, rheumatic ostalgia, dysmenorrhes, puerperal, the stasis of blood was stagnant, traumatic injury, and knife injury is hemorrhage.
Fructus Fici Beecheyanae, [nature and flavor] are pungent, sour, puckery, temperature." national Chinese herbal medicine compilation ": [function cures mainly] dispels the wind removing dampness, pain relieving.Cure mainly articular rheumatic pain, wind syndrome of head pain, traumatic injury, menoxenia, stomachache, pain in the lumbar region leukorrhagia, development in children is slow." China's book on Chinese herbal medicine ": [function cures mainly] loosening bowel to relieve constipation; Removing toxic substances and promoting subsidence of swelling.Main constipation; Swelling and pain of hemorrhoid.
Bodhi is fragrant, and [nature and flavor] are pungent, sweet, flat.[function cures mainly] enriching yin and nourishing kidney, suppressing the hyperactive liver improving eyesight, reducing swelling and alleviating pain.Cure cold, dizziness headache, hypertension, anemia, chronic enterogastritis, menoxenia, mastitis, the diseases such as sore.
Radix Tylophorae arenicolae, [nature and flavor] are pungent, flat.[function cures mainly] the kidney invigorating, spleen invigorating, removing toxic substances.Control chronic consumptive disease chronic cough, edema, leucorrhea, menoxenia, scrofula, skin ulcer scabies." Shaanxi Chinese herbal medicine ": " enriching yin and nourishing kidney, invigorating the spleen and benefiting QI, regulating menstruation and activating blood.Control menoxenia, deficiency of YIN leucorrhea.”
Auricularia polytricha (Mout) Sacc., [nature and flavor] are sweet, flat.[function cures mainly] fills blood, lung moistening, hemostasis.For Qi and blood deficiency, extremity are twitched, cough due to deficiency of the lung, spitting of blood, spit blood, epistaxis, metrorrhagia, hypertension, constipation.
Fructus Mori, [nature and flavor] are sweet, sour, cold.[function cures mainly] to be enriched blood YIN nourishing, is promoted the production of body fluid and moisturize.For vertigo and tinnitus, palpitation and insomnia, early whitening of beard and hair, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, blood deficiency and constipation.
Cortex cercis chinensis, [nature and flavor] are bitter, flat.[function cures mainly] promoting blood circulation to restore menstrual flow, subduing swelling and detoxicating.Control anemofrigid-damp arthralgia, women's amenorrhea, vim and vigour pain, sore throat, drench disease, carbuncle, tinea scabies, traumatic injury, snake bite and insect sting.
Brown sugar (Saccharum Sinensis Roxb.), [nature and flavor] are sweet, temperature.Liver is delayed in [function cures mainly] invigorating middle warmer, invigorates blood circulation and the stasis of blood.Control disease that postpartum lochia can't go, xerostomia is vomitted the sound of vomiting, weakness with emaciation dysentery." medical center bun is wanted ": " slow liver, blood stasis removing, invigorates blood circulation, intestine moistening for warming the stomach, spleen reinforcing.”
Semen Sterculiae Lychnophorae, [nature and flavor] are sweet light, cool.[function cures mainly] clearing heat and moistening lung; Sore-throat relieving; Bowel relieving relieving constipation.Main dry cough without phlegm; Laryngopharynx swelling and pain; Hoarseness; Toothache; Constipation with heat retention.
Any one peroral dosage form on pharmaceutics made by above-mentioned raw materials medicine by the present invention, and as tablet, pill, powder, decoction, capsule etc., preferred dosage form is capsule.
Present invention also offers a kind of preparation method of above-mentioned Chinese medicine, it mainly comprises following step: get the above-mentioned Chinese crude drug of recipe quantity and be broken into coarse powder, the alcoholic solution that volumetric concentration is 45%-85% is doubly added according to the 8-10 of coarse powder gross weight, reflux, extract, three times, return time is 2-5h, filter, filtrate recycling ethanol, cold filtration is condensed into the Chinese medical concrete that relative density is 1.10-1.20; Dry, pulverize into fine powder, incapsulate shell, obtained capsule.
Another object of the present invention is to provide a kind of medical usage, i.e. the purposes of above-mentioned Chinese medicine in preparation treatment chloasma medicine.
In prescription of the present invention with Fructus Fici Pumilae, Radix Ophiopogonis, Radix seu Caulis Verntilaginis Leiocarpae, Indigofera stachyoides Lindl., Radix Kadsurae Coccineae, Fructus Fici Beecheyanae for principal agent, be aided with bodhi perfume (or spice), Radix Tylophorae arenicolae, Auricularia polytricha (Mout) Sacc., Fructus Mori, Cortex cercis chinensis, brown sugar (Saccharum Sinensis Roxb.), Semen Sterculiae Lychnophorae, compatibility is reasonable, there are enriching yin and nourishing kidney, blood circulation promoting and enriching, dredging collateral, dissipating blood stasis, effect of loosening bowel to relieve constipation, fundamentally can treat chloasma.It has Be very effective, safe without toxic side effect, the advantage that cure rate is high.
Detailed description of the invention
Do further, to it should be noted that to the present invention below in conjunction with specific embodiment, following embodiment, only for explaining the present invention, does not limit the present invention.
(1) preparation of medicine
The preparation of embodiment 1 capsule of the present invention
Prescription: Fructus Fici Pumilae 20 parts, Radix Ophiopogonis 23 parts, Radix seu Caulis Verntilaginis Leiocarpae 28 parts, Indigofera stachyoides Lindl. 30 parts, Radix Kadsurae Coccineae 30 parts, Fructus Fici Beecheyanae 21 parts, fragrant 10 parts of bodhi, Radix Tylophorae arenicolae 9 parts, Auricularia polytricha (Mout) Sacc. 13 parts, 12 parts, Fructus Mori, Cortex cercis chinensis 7 parts, brown sugar (Saccharum Sinensis Roxb.) 9 parts, Semen Sterculiae Lychnophorae 4 parts.
Preparation method: get the above-mentioned Chinese crude drug of recipe quantity and be broken into coarse powder, add according to 8 times of coarse powder gross weight the alcoholic solution that volumetric concentration is 75%, reflux, extract, three times, return time is 3h, filter, filtrate recycling ethanol, cold filtration is condensed into the Chinese medical concrete that relative density is 1.10-1.20; Dry, pulverize into fine powder, incapsulate shell, obtained capsule, 0.5g/ grain.
The preparation of embodiment 2 capsule of the present invention
Prescription: Fructus Fici Pumilae 22 parts, Radix Ophiopogonis 25 parts, Radix seu Caulis Verntilaginis Leiocarpae 30 parts, Indigofera stachyoides Lindl. 32 parts, Radix Kadsurae Coccineae 32 parts, Fructus Fici Beecheyanae 23 parts, fragrant 12 parts of bodhi, Radix Tylophorae arenicolae 11 parts, Auricularia polytricha (Mout) Sacc. 15 parts, 14 parts, Fructus Mori, Cortex cercis chinensis 9 parts, brown sugar (Saccharum Sinensis Roxb.) 11 parts, Semen Sterculiae Lychnophorae 6 parts.
Preparation method is with embodiment 1.
The preparation of embodiment 3 capsule of the present invention
Prescription: Fructus Fici Pumilae 21 parts, Radix Ophiopogonis 24 parts, Radix seu Caulis Verntilaginis Leiocarpae 29 parts, Indigofera stachyoides Lindl. 31 parts, Radix Kadsurae Coccineae 31 parts, Fructus Fici Beecheyanae 22 parts, fragrant 11 parts of bodhi, Radix Tylophorae arenicolae 10 parts, Auricularia polytricha (Mout) Sacc. 14 parts, 13 parts, Fructus Mori, Cortex cercis chinensis 8 parts, brown sugar (Saccharum Sinensis Roxb.) 10 parts, Semen Sterculiae Lychnophorae 5 parts.
Preparation method is with embodiment 1.
(2) acute toxicity and chronic toxicity experiment
Preliminary experiment shows, and Chinese medicine of the present invention, toxicity is very little, cannot measure LD
50, therefore, according to maximum amount feeding.
1 animal acute toxicity test
Test drug: obtained by embodiment of the present invention 1-3, Chinese medicine capsules is numbered A, B, C.Test animal used: regular grade NIH mice, body weight 21g ± 6g, male and female half and half, female mice is all without pregnant;
The Chinese medicine capsules of mouse stomach embodiment 1-3, under 784.9g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 1 hours recovers normal, Continuous Observation 7 days after administration, none dead mouse, and overall health of patients, diet, take the photograph water, urine and body weight increase all normal.Experimental result shows: the maximum dosage-feeding of the Chinese medicine granules of mouse stomach embodiment 1-3 is 784.9g crude drug/kg/d(LD
50> 784.9g crude drug/kg).Chinese medicine preparation clinical application every day total amount of the present invention is 0.18g crude drug/kg/d; By weighing machine, the dosis tolerata of mouse stomach Chinese medicine preparation of the present invention is 4360.6 times of clinical patient.Point out this medicine acute toxicity extremely low, clinical drug safety.
2 long-term toxicity test for animals
Medicine: embodiment of the present invention 1-3 gained Chinese medicine capsules.
Animal: regular grade SD rat, original body mass 217 ± 6g, male and female half and half, female rats is all without pregnant.
Method and result:
(1) 3 kind of Chinese medicine capsules: be divided into high, medium and low three dosage groups, per weight dosage is respectively 180,60,20 times of patient's dose;
(2) experimental mouse is divided into 4 groups at random, wherein the capsule of 3 groups of difference gavages, 3 kinds of three dosage, remains one group of gavage normal saline (40 times of patient's dose); All 4 groups of all continuous gavages 180 days, observe animal general toxic reaction and the order of severity, check each position, and carry out hematology, the pathological examination of the main organs such as ALT, BUN and the heart, liver, spleen, lung, kidney, stomach after execution by rule of operation;
(3) through long-term feeding, all there is not toxic reaction in 4 groups of rats.Physically well develop.Macroscopic appearance and main organs no abnormality seen.Peripheral hemogram and Serum ALT, BUN compare with matched group and change without pathologic.The all not significant changes such as the pathological replacement heart, liver, spleen, lung, kidney, stomach, therefore, think through proved by pathology, 3 kinds of Chinese medicine capsules show without chronic toxicity animal.
By above two toxicity tests, prove that the present invention is safe by the Chinese medicine capsules that embodiment 1-3 makes, have no side effect, can be taken by patient.
(3) clinical trial
Experimenter's data: accept patient with chloasma in year June in August, 2012 to 2014 for medical treatment, filters out and is applicable to doing clinical trial person 120 example, be female patient, age 23-59 year, all showed speckle in various degree when being chosen as experimenter.
Grouping: experimenter is divided into 3 groups, often organizes 40 examples.
The made Chinese medicine capsules of test medication: embodiment 1-3.
Test method: the made Chinese medicine capsules of oral embodiment 1-3 respectively, 3 times on the 1st, each 24 weeks is a course for the treatment of, and treat 3 courses for the treatment of continuously, healing person stops administration immediately.Treatment all terminates, statistical analysis result of the test; Treatment end is paid a return visit healing patient for 6 months, statistics recurrent cases.
Judgment criteria: cure: mottle disappears, face is as before bright and clean; Effective: mottle is desalinated, and area obviously reduces; Invalid: mottle disappears less than 1/3.
Result of the test is added up: after total Test terminates, and result of the test statistics is as shown in table 1:
Table 1 result of the test statistical analysis table
Analysis of statistical results: can calculate from table 1, the average cure rate of the present invention is 92.5%, and average total effective rate is 100%, and average relapse rate is 0, illustrate that Be very effective, the cure rate for the treatment of by Chinese herbs chloasma of the present invention are high, relapse rate is lower, safe without toxic side effect.
Claims (5)
1. treat a Chinese medicine for chloasma, it is characterized in that being obtained by following weight parts Chinese crude drug: Fructus Fici Pumilae 20-22 part, Radix Ophiopogonis 23-25 part, Radix seu Caulis Verntilaginis Leiocarpae 28-30 part, Indigofera stachyoides Lindl. 30-32 part, Radix Kadsurae Coccineae 30-32 part, Fructus Fici Beecheyanae 21-23 part, the fragrant 10-12 part of bodhi, Radix Tylophorae arenicolae 9-11 part, Auricularia polytricha (Mout) Sacc. 13-15 part, Fructus Mori 12-14 part, Cortex cercis chinensis 7-9 part, brown sugar (Saccharum Sinensis Roxb.) 9-11 part, Semen Sterculiae Lychnophorae 4-6 part.
2. the Chinese medicine for the treatment of chloasma as claimed in claim 1, is characterized in that being obtained by following weight parts Chinese crude drug: Fructus Fici Pumilae 21 parts, Radix Ophiopogonis 24 parts, Radix seu Caulis Verntilaginis Leiocarpae 29 parts, Indigofera stachyoides Lindl. 31 parts, Radix Kadsurae Coccineae 31 parts, Fructus Fici Beecheyanae 22 parts, fragrant 11 parts of bodhi, Radix Tylophorae arenicolae 10 parts, Auricularia polytricha (Mout) Sacc. 14 parts, 13 parts, Fructus Mori, Cortex cercis chinensis 8 parts, brown sugar (Saccharum Sinensis Roxb.) 10 parts, Semen Sterculiae Lychnophorae 5 parts.
3. the Chinese medicine for the treatment of chloasma as claimed in claim 1 or 2, is characterized in that: described Chinese medicine is tablet, pill, powder, decoction or capsule.
4. prepare the method for the Chinese medicine for the treatment of chloasma as claimed in claim 3 for one kind, it is characterized in that comprising the following steps: get recipe quantity Chinese crude drug and be broken into coarse powder, the alcoholic solution that volumetric concentration is 45%-85% is doubly added according to the 8-10 of coarse powder gross weight, reflux, extract, three times, return time is 2-5h, filter, filtrate recycling ethanol, cold filtration is condensed into the Chinese medical concrete that relative density is 1.10-1.20; Dry, pulverize into fine powder, incapsulate shell, obtained capsule.
5. described in claim 1 or 2, treat the application of Chinese medicine in preparation treatment chloasma medicine of chloasma.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101518614A (en) * | 2009-04-03 | 2009-09-02 | 杜继珍 | Chinese patent medicine for treating chloasma |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101518614A (en) * | 2009-04-03 | 2009-09-02 | 杜继珍 | Chinese patent medicine for treating chloasma |
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Application publication date: 20150429 |