CN104547381A - Medicine for treating brain tumor caused by stagnation of qi and blood, and preparation method thereof - Google Patents

Medicine for treating brain tumor caused by stagnation of qi and blood, and preparation method thereof Download PDF

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CN104547381A
CN104547381A CN201410845355.0A CN201410845355A CN104547381A CN 104547381 A CN104547381 A CN 104547381A CN 201410845355 A CN201410845355 A CN 201410845355A CN 104547381 A CN104547381 A CN 104547381A
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田静
吴海良
侯宝青
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Abstract

The invention discloses a medicine for treating a brain tumor caused by the stagnation of qi and blood, and a preparation method thereof. The medicine comprises the following raw materials: peach kernel, earthworm, cowherb seed, musk, yellow wine, white mustard seed, dried body of ground beetle, common selfheal fruit-spike, chastetree fruit, chrysanthemum, notopterygium root, paniculate swallowwort root, dragon's blood, suberect spatholobus stem, pangolin, divaricate saposhnikovia root, fineleaf schizonepeta herb, Chinese angelica, asarum, radix glycyrrhizae preparata, cantonese speranskia, common monkshood root and delphinium root. The medicine follows the principles of activating blood, removing blood stasis, resolving lump and inducing resuscitation, has the effects of promoting the flow of meridians and collaterals, relieving pain, regulating the upper body with warmth and nourishing qi and blood, is mainly used for treating the brain tumor caused by the stagnation of the qi and the blood, is a new medicine which is simple in preparation process, low in toxic and side effects, convenient to take, easy to manufacture, low in cost, exact in treatment effect and worth of being popularized, and can reach focal infection directly.

Description

A kind ofly treat medicine of QI and blood stagnation cerebroma and preparation method thereof
Technical field
The present invention relates to the medicinal preparation containing deriving from plant, animal or raw mineral materials, particularly a kind ofly treating medicine of QI and blood stagnation cerebroma and preparation method thereof.
Background technology
The tumor being grown on intracranial is commonly referred to as cerebroma, comprises the primary brain tumor occurred by brain essence and the Secondary cases cerebroma being transferred to intracranial by other positions of health.Primary brain tumor divides again optimum and pernicious according to its biological nature.Benign encephaloma poor growth, peplos is more complete, not infiltrate surrounding tissues and well differentiated; Malignant brain tumor growth is very fast, and without peplos, boundary is not obvious, in infiltrative growth, and poorly differentiated.No matter optimum or pernicious, all can extrude, pass normal cerebral tissue, cause intracranial pressure to raise, threaten the life of people.Intracranial tumor can betide any age, is the most common with 20-50 year.
Clinical manifestation: look its histological type, happening part, the difference of main speed is widely different, so it has three with feature: increased intracranial pressure, symptoms of intracranial hypertension accounts in more than 90% Patients with Brain Tumors and occurs, it shows as: 1, headache, Nausea and vomiting, headache multidigit, in forehead and temples, are the aggravation of persistent headache paroxysmal, headache in morning of being everlasting is heavier, and the intermission can be normal.2, papilloedema and visual deterioration.3, spirit and disturbance of consciousness and other symptoms: dizziness, diplopia, temporary amaurosis, damping off, confusion, spirit uneasiness or indifferent, can epilepsy be there is, even go into a coma.4, changes of vital signs: when moderate and severe acute increased intracranial pressure, often causes breathing, pulse, slows down, and blood pressure raises.
The clinical symptoms of cerebral hemisphere tumor: (1) mental symptom (2) epilepsy (3) tractus pyramidalis infringement symptom (4) sensory disturbance (5) aphasia (6) visual field changes
The clinical manifestation of tumor in sellar area: (1) visual disorder (2) endocrine dysfunction.
Tumors of pineal region clinical symptoms: quadrigemina suffers oppression symptom: look obstacle, reaction of pupil to light and regulate reaction obstacle, tinnitus, deafness; Hold thing shakiness, lurch, eyeball level is trembled, limbs paresis, both sides pyramidal sign; Diabetes insipidus, drowsiness, fat, whole body arrested development, male's observability is precocious.
The clinical symptoms of tumor of posterior cranial fossa: (1) hemisphaerium cerebelli symptom: main manifestations is affected limb ataxia, and also can occur Ipsilateral hypomyotonia or no-station pole canopy, knee jerk is blunt, and eyeball level is trembled, also can occur that vertical or rotatory is trembled sometimes.(2) vermis cerebelli symptom: main manifestations is the ataxia of trunk and Lower Distal Extremities, during walking, two foots are far isolated, lurch, or roll as drunkard.(3) brain stem symptom: the clinical manifestation of feature is for occurring crossed paralysis, as many in middle cerebral lesion, show as pathological changes side oculomotor paralysis, pon pathological changes, pathological changes branch hole ball abduction and Bekhterev's symptom can be shown as, homonymy face sensory disturbance and dysacousis, can to there is after homonymy lingualis paralysis, throat paralysis, tongue 1/3 sense of taste disappearance etc. in oblongata pathological changes.
Cerebellopontine angle symptom: often show as tinnitus, auditory dysesthesia, dizzy, face is numb, facial spasm, Bekhterev's symptom and hoarseness, and drinking water is choked and coughed, the ataxia of sick side and level shake eye.
Progressive symmetric erythrokeratodermia symptom: tumor there will not be pressure symptom in early days sometimes, along with the increase of tumor body, can show as pressure symptom in various degree, the speed increased according to tumor location and grade malignancy, tumor, the also faster or slower of symptom progress extent.
Pathophysiology: long-term dietary structure, the factors such as living habit cause body constitution acidify, and the function of human body integral declines, and cause and suffer from a deficiency of the kidney, The liver and the kidney have a common source, and liver of suffering from a deficiency of the kidney is also empty, and then cause part of the body cavity above the diaphragm housing the heart and lungs metabolic cycles slack-off, blocks cerebral arteries, and vim and vigour stagnate.At this moment some brain parasites, virus, with regard to amount reproduction, causes brain major injury.The acidify of cerebral tissue liquid, brain cell is in acid body fluid, and then forms the decline of brain cell dissolved oxygen amount, causes the activity decrease of cell, metabolic cycles slows down, when dropping to 65% of normal value, normal cell just cannot be survived, but also have do not stint change chromosome take the initiative variation cell, the phenotype of cell changes, tumor character is expressed, and these cells increase rapidly, thus forms real tumor entity.In addition, in addition because the canceration of its hetero-organization occurs body constitution acidify health, again because brain function declines, brain tissue's liquid acidify, cancerous cell is availed oneself of the opportunity to get in, and causes cerebroma.
Differential diagnosis in tcm: 1, expectorant poison coagulation type: headache and dizzy, numb limbs and tense tendons, heavy sensation of the body asthenia, stiff tongue and retardation in speech, nausea and vomiting, blurred vision, excessive sputum and oppression feeling over the chest, enlarged tongue has indentation, and tongue is white thick greasy, rolling pulse or stringy and thready pulse.2, QI and blood stagnation: headache feeling of fullness in the head, complexion is dark dim, blurred vision, cyanotic lips, and body of the tongue purple is dim or have ecchymosis, thready and hesitant pulse or string.3, liver-wind stirring up internally type: headache and dizzy, one's ears rang and spots danced before one's eyes, irritable, and tic is trembled, stiff tongue aphasia, stupor stiffness of the nape, nausea and vomiting, the few tongue of red tongue, stringy and thready pulse and counting.4, excessive heat of liver and gallbladder type: headache feeling of fullness in the head, if cone is as split, vomiting is as spray, and dry stool is urinated red, tongue is dim red or deep red red, yellow fur, wiry and frequent pulse.5, deficiency of spleen-YANG and kidneyYANG, deficiency of liver-blood type: have a dizzy spell, Hiccough and deaf, visual disorder, soreness of the waist and knees, coldness of the body with chills, lazy speech of breathing hard, loose stool clearly of urinating, or dry throat and mouth, flushed cheeks night sweat, dysphoria with feverish sensation in the chest palms and soles, deep,thready and forceless pulse.
Therapeutic Method:
Operative treatment: for primary tumor, gives surgical resection, is removed totally by tumor cell as far as possible, avoids hyperplasia to be still the most general Therapeutic mode.For benign tumor, the probability that adopting performs the operation excises completely is higher, and the survival rate of patient is also higher, as brain or cerebellum astrocytoma, sella turcica craniopharyngioma, ventricles of the brain choroid plexus tumor etc., do not need to carry out lonizing radiation or chemotherapy, incidence of recurrences is low, but regularly need do CT or MRI reinspection.For general malignant brain tumor, as degeneration astrocytoma, medulloblastoma, ependymoa, teratoma etc., can excise completely or close excision person completely, prognosis is better, but must add radiotherapy and or chemotherapy, can reach and control the object of tumor growth.
Chemotherapy: the chemotherapy of cancer at present makes much progress, but due to the special construction of brain blood brain barrier (BBB), the chemotherapy of cerebroma is still subject to many restrictions, any chemotherapeutics can only pass through blood vessel lining cells by the fat-soluble of medicine, and then enter tumor cell generation effect, such mode influences pharmaceutically-active speed and efficiency.Current clinical conventional chemotherapeutics is nitrosourea alkylating agent BCNU and CCNU, or with PVC scheme (procarbazine+vincristine+CCNU), has certain curative effect, but has delay and the side effect such as accumulation bone marrow depression and pulmonary toxicity, easily produces drug resistance.
Radiotherapy: radiation cure be utilize lonizing radiation or gamma-rays, fast neutron ray kills tumor cell, is called for short radiotherapy.
Chemistry is used to carry out the treatment of the cerebral tumor, effect is generally observable, but may cause side effect to health, the chemotherapy of the cerebral tumor needs the drug combination of several drugs, the single application poor effect of chemotherapeutics, the object of drug combination increases curative effect, reduce toxicity, strengthen life quality extending life, cerebral tumor chemotherapy drugs all may cause gastrointestinal reaction and myelosuppressive effect, bone marrow depression can be sent out, so chemicals can not life-time service after continuous use.
Chinese herbal medicine be with animal, plant, mushroom and mineral etc. for raw material, there is natural structure and activity, to the effect of body mainly with immune cell activated, it is main for improving immunologic function, its metabolite or processing waste back to nature, also by the decomposition such as microorganism, enzyme, can participate in the material circulation of biosphere again, reduce the untoward reaction of chemotherapeutics, the reason of Drug side reaction, chemotherapy has the strict course for the treatment of and therapeutic dose, mainly based on Formulations for systemic administration, reach the object for the treatment of, reduce the generation of disease.Therefore very large advantage is had.
Summary of the invention
For solving the problems of the technologies described above, medicine provided by the invention, with blood circulation promoting and blood stasis dispelling, eliminating stagnation is had one's ideas straightened out for principle, hold concurrently with QI invigorating and body resistance strengthening, enrich blood admittedly superintend and direct, reinforcement anticreep, clearing away deficiency-heat, promoting digestion and invigorating the stomach, strengthen its resistivity, there is the advantageous feature such as evident in efficacy, cheap, nonhazardous, no drug residue, pure natural property, safe ready, complete function in treatment QI and blood stagnation cerebroma.
In order to solve the problems of the technologies described above, the invention provides a kind of medicine for the treatment of QI and blood stagnation cerebroma, wherein, described medicine comprises following raw medicinal material: Semen Persicae, Pheretima, Semen Vaccariae, Moschus, yellow wine, Semen Sinapis Albae, eupolyphaga, Spica Prunellae, Fructus Viticis, Flos Chrysanthemi, Rhizoma Et Radix Notopterygii, Radix Cynanchi Paniculati, Sanguis Draxonis, Caulis Spatholobi, Squama Manis, Radix Saposhnikoviae, Herba Schizonepetae, Herba Asari, Radix Angelicae Sinensis, Radix Glycyrrhizae Preparata, Herba speranskiae cantonensis, Radix Aconiti and chicken foot Radix Aconiti Kusnezoffii.
Wherein, the ratio of weight and number of described raw medicinal material is: Semen Persicae 30-40 weight portion, Pheretima 5-8 weight portion, Semen Vaccariae 15-20 weight portion, Moschus 10-15 weight portion, yellow wine 10-20 weight portion, Semen Sinapis Albae 10-20 weight portion, eupolyphaga 5-8 weight portion, Spica Prunellae 15-20 weight portion, Fructus Viticis 10-20 weight portion, Flos Chrysanthemi 35-40 weight portion, Rhizoma Et Radix Notopterygii 20-25 weight portion, Radix Cynanchi Paniculati 10-20 weight portion, Sanguis Draxonis 15-20 weight portion, Caulis Spatholobi 25-30 weight portion, Squama Manis 15-20 weight portion, Radix Saposhnikoviae 10-20 weight portion, Herba Schizonepetae 20-30 weight portion, Herba Asari 5-7 weight portion, Radix Angelicae Sinensis 20-25 weight portion, Radix Glycyrrhizae Preparata 10-20 weight portion, Herba speranskiae cantonensis 20-25 weight portion, Radix Aconiti 2-5 weight portion and chicken foot Radix Aconiti Kusnezoffii 3-5 weight portion.
Wherein, also comprise Fructus Gleditsiae Abnormalis, Lysimachia trientaloides Hemsl., Folium Ginkgo, the ratio of weight and number of described raw medicinal material is: Semen Persicae 30-40 weight portion, Pheretima 5-8 weight portion, Semen Vaccariae 15-20 weight portion, Moschus 10-15 weight portion, yellow wine 10-20 weight portion, Semen Sinapis Albae 10-20 weight portion, eupolyphaga 5-8 weight portion, Spica Prunellae 15-20 weight portion, Fructus Viticis 10-20 weight portion, Flos Chrysanthemi 35-40 weight portion, Rhizoma Et Radix Notopterygii 20-25 weight portion, Radix Cynanchi Paniculati 10-20 weight portion, Sanguis Draxonis 15-20 weight portion, Caulis Spatholobi 25-30 weight portion, Squama Manis 15-20 weight portion, Radix Saposhnikoviae 10-20 weight portion, Herba Schizonepetae 20-30 weight portion, Herba Asari 5-7 weight portion, Radix Angelicae Sinensis 20-25 weight portion, Radix Glycyrrhizae Preparata 10-20 weight portion, Herba speranskiae cantonensis 20-25 weight portion, Radix Aconiti 2-5 weight portion, chicken foot Radix Aconiti Kusnezoffii 3-5 weight portion, Fructus Gleditsiae Abnormalis 20-30 weight portion, Lysimachia trientaloides Hemsl. 15-20 weight portion and Folium Ginkgo 30-35 weight portion.
Wherein, the ratio of weight and number of described raw medicinal material is: Semen Persicae 40 weight portion, Pheretima 8 weight portion, Semen Vaccariae 20 weight portion, Moschus 15 weight portion, yellow wine 20 weight portion, Semen Sinapis Albae 20 weight portion, eupolyphaga 5 weight portion, Spica Prunellae 15 weight portion, Fructus Viticis 10 weight portion, Flos Chrysanthemi 40 weight portion, Rhizoma Et Radix Notopterygii 25 weight portion, Radix Cynanchi Paniculati 20 weight portion, Sanguis Draxonis 15 weight portion, Caulis Spatholobi 30 weight portion, Squama Manis 20 weight portion, Radix Saposhnikoviae 20 weight portion, Herba Schizonepetae 30 weight portion, Herba Asari 5 weight portion, Radix Angelicae Sinensis 25 weight portion, Radix Glycyrrhizae Preparata 10 weight portion, Herba speranskiae cantonensis 20 weight portion, Radix Aconiti 2 weight portion and chicken foot Radix Aconiti Kusnezoffii 3 weight portion.
Wherein, the ratio of weight and number of described raw medicinal material is: Semen Persicae 40 weight portion, Pheretima 5 weight portion, Semen Vaccariae 20 weight portion, Moschus 15 weight portion, yellow wine 10 weight portion, Semen Sinapis Albae 20 weight portion, eupolyphaga 5 weight portion, Spica Prunellae 20 weight portion, Fructus Viticis 10 weight portion, Flos Chrysanthemi 40 weight portion, Rhizoma Et Radix Notopterygii 25 weight portion, Radix Cynanchi Paniculati 20 weight portion, Sanguis Draxonis 15 weight portion, Caulis Spatholobi 30 weight portion, Squama Manis 20 weight portion, Radix Saposhnikoviae 10 weight portion, Herba Schizonepetae 30 weight portion, Herba Asari 5 weight portion, Radix Angelicae Sinensis 25 weight portion, Radix Glycyrrhizae Preparata 20 weight portion, Herba speranskiae cantonensis 20 weight portion, Radix Aconiti 2 weight portion, chicken foot Radix Aconiti Kusnezoffii 3 weight portion, Fructus Gleditsiae Abnormalis 20 weight portion, Lysimachia trientaloides Hemsl. 15 weight portion and Folium Ginkgo 30 weight portion.
In order to solve the problems of the technologies described above, present invention also offers a kind of preparation method for the treatment of the medicine of QI and blood stagnation cerebroma, wherein, the dosage form of described medicine is decoction, and its preparation method comprises the following steps:
Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 3-6cm, soak 3-10 hour;
Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 40-80 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate a, for subsequent use;
Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 3-6cm, soaks 3-10 hour;
Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 35-55 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.
Wherein, the dosage form of described medicine is capsule, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 80 ~ 90%, reflux 2 ~ 5 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 80 ~ 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 ~ 5 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.05 ~ 0.5:0.05 ~ 0.1, incapsulate in housing, obtain capsule by described capsule 's content.
Wherein, the dosage form of described medicine is injection, and its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 97%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 80% ~ 90%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 45 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 97%,
3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 20g ~ 40g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 40 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
The invention has the beneficial effects as follows: medicine of the present invention, utilize the theory of Chinese medical science that China is traditional, with blood circulation promoting and blood stasis dispelling, eliminating stagnation is had one's ideas straightened out for principle, hold concurrently with QI invigorating and body resistance strengthening, enrich blood admittedly superintend and direct, reinforcement anticreep, clearing away deficiency-heat, promoting digestion and invigorating the stomach simultaneously, can benefiting QI and nourishing blood, regulating qi-flowing for strengthening spleen, strengthen its resistivity, there is evident in efficacy, cheap, nonhazardous in treatment QI and blood stagnation cerebroma, no drug residue, pure natural property, safe ready, complete function drug effect go directly the advantageous feature such as focus.
Detailed description of the invention
For the corresponding symptom suffering from cerebroma appearance, medicine of the present invention, utilize the theory of Chinese medical science that China is traditional, with blood circulation promoting and blood stasis dispelling, eliminating stagnation is had one's ideas straightened out for principle, hold concurrently with QI invigorating and body resistance strengthening, enrich blood admittedly superintend and direct, reinforcement anticreep, clearing away deficiency-heat, promoting digestion and invigorating the stomach simultaneously, can benefiting QI and nourishing blood, regulating qi-flowing for strengthening spleen, strengthens its resistivity, has evident in efficacy in treatment QI and blood stagnation cerebroma.
Wherein medicine comprises: Semen Persicae, Pheretima, Semen Vaccariae, Moschus, yellow wine, Semen Sinapis Albae, eupolyphaga, Spica Prunellae, Fructus Viticis, Flos Chrysanthemi, Rhizoma Et Radix Notopterygii, Radix Cynanchi Paniculati, Sanguis Draxonis, Caulis Spatholobi, Squama Manis, Radix Saposhnikoviae, Herba Schizonepetae, Herba Asari, Radix Angelicae Sinensis, Radix Glycyrrhizae Preparata, Herba speranskiae cantonensis, Radix Aconiti and chicken foot Radix Aconiti Kusnezoffii.Also comprise Fructus Gleditsiae Abnormalis, Lysimachia trientaloides Hemsl., Folium Ginkgo.We's compatibility is reasonable, rigorous, sensiblely to invigorate blood circulation, eliminating stasis and resolving masses for Therapeutic Principle, hold concurrently with the meridian dredging pain relieving, pungent Wen Xuan on, invigorating QI and blood treats cerebroma, can obtain desirable effect.We carry out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, addition or subtraction of changes, Moschus, Herba speranskiae cantonensis, Radix Aconiti and chicken foot Radix Aconiti Kusnezoffii the meridian dredging in its side, open meridians, thoroughly muscles and bones; Semen Persicae, Pheretima, Semen Vaccariae, Radix Cynanchi Paniculati, Caulis Spatholobi, Squama Manis, Herba Asari, yellow wine, Fructus Gleditsiae Abnormalis, Lysimachia trientaloides Hemsl., Folium Ginkgo blood circulation and promoting silt tissue regeneration promoting eliminating stagnation; On Fructus Viticis, Flos Chrysanthemi, Rhizoma Et Radix Notopterygii, Radix Saposhnikoviae, Herba Schizonepetae, sensible a surname of the pungent temperature of Herba Asari, draw all medicines up, make the sensible brain key of the gas of fragrance energy; Caulis Spatholobi, Radix Angelicae Sinensis, Radix Glycyrrhizae Preparata blood yiqi, yin nourishing righting; Semen Persicae, Flos Carthami, Radix Paeoniae Rubra, Rhizoma Et Radix Notopterygii, Herba Asari pain relieving; Semen Persicae, Pheretima, Semen Vaccariae, Semen Sinapis Albae, eupolyphaga, Spica Prunellae, the blood stasis dispelling of Squama Manis eliminating stagnation.Make a general survey of full side, compatibility is rigorous.
Now the pharmacological properties effect of each taste medicine is described below:
Semen Persicae: bitter in the mouth, sweet and property are put down, and can enter the heart, liver, large intestine, blood circulation promoting and blood stasis dispelling effect is very wide, availablely controls the various worn-out disease of stagnation of blood stasis.For lump in the abdomen caking, lung abscess acute appendicitis, tumbling down is grieved, amenorrhea dysmenorrhea, and puerperal, stasis of blood pain waited disease.This product water decoction-alcohol sedimentation liquid can make isolated rabbit ear vein vascular flow increase, and has vasodilator effect.This product protein ingredient in two homogeneous protein ingredients, intravenous administration, xylol induced mice ear acute inflammatory reaction, all has remarkable inhibitory action.Semen Persicae water extract can suppress the generation of skin-sensitizing antibodies in mice serum and house mouse spleen hemolytic cell, the pigment seepage discharge of oral PCA reaction (passive cutaneous anaphylaxis, PCA) that the antiserum that mice contains skin hypersensitivity antibody can be suppressed to cause of its ethanol extraction.Bitter no core glycoside, has antitussive effect.Fatty oil (almond oil) in Semen Persicae has anthelmintic action, is 80.8% to the anthelminthic effect of pinworm, is 70% to ascarid effect.
Pheretima: the property of medicine: salty, cold.Return liver, spleen, urinary bladder channel.Effect: heat clearing away is calmed the frightened, and dredging collateral, relievings asthma, diuresis.For calentura mania and irritation, infantile convulsion, cough with asthma, headache conjunctival congestion, laryngopharynx swelling and pain, urinary obstruction, Fengshi Guanjie pain, the diseases such as hemiplegia Pheretima dish.External is coated with the disease such as erysipelas, dermatitis rhus.Lumbar injection earthworm injection 10g/kg in advance, surveys the pre-always cerebral infarction that artery ligation causes to mongolian gerbils one and has certain preventive effect, can alleviate the symptom of cerebral infarction; Mice only gavages Pheretima extract l1mg/, continuous 58d, to the euphorbia egg decoctum transplanted every day.Have obvious inhibitory action, not only tumor body obviously reduces, and can extend the life cycle of mice.
Semen Vaccariae: bitter is flat; Return liver, stomach warp.Can promoting the circulation of blood regulating menstruation, reducing swelling and alleviating pain, lactogenesis of invigorating blood circulation, expedite the emergence of stimulating milk secretion, thymus dredging in puerperal.For blood stasis amenorrhea, dysmenorrhea, difficult labour; Lack of lactation after delivery, acute mastitis swells and ache; Pyretic stranguria, stranguria with blood, stranguria caused by urinary stone." book on Chinese herbal medicine newly organized ": " Semen Vaccariae, its property is very anxious, descending and do not go up passerby also.Inverse and the upper punch person of all diseases with can fall, therefore can rely on to make it use as minister also.But its property is overrun, should be for a long time unsuitable temporarily, can not know again yet.Or ask: Semen Vaccariae can stimulating milk secretion, be also can be up thing also.Not knowing that breast can not descend and purgation, is descending after all, but not also up.Upper Jiao has can descend person, all can descend logical, non-only row in the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels not all right in the part of the body cavity above the diaphragm housing the heart and lungs also." Semen Vaccariae has antiearly pregnancy, Antiimplantation Action, also there is regulation of physiological functions, affect the effect of internal metabolism. also have report to think, Semen Vaccariae decoct has contraction to Isolated Rat Uterus; Its ethanol extract effect is especially strong.
Moschus: pungent, temperature.GUIXIN, spleen channel.Effect: refreshment of having one's ideas straightened out, promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain.
Yellow wine: abnormal smells from the patient is bitter, sweet, pungent.Winter, temperature drank yellow wine, can invigorate blood circulation cold relieving, dredge the meridian passage.
Semen Sinapis Albae: acrid in the mouth, temperature, nontoxic.Enter the warp of liver, spleen, lung, stomach, the heart and collaterals of the uterus.Can remove cold air, settling five organs, by the expectorant of film diaphragm, ward off stealthy gas, the addiction that disappears malaria, drop interests Dingchuan, sharp key improving eyesight, and removing blood stasis relieves the pain, and all can prove effective.Can energy dissipating fall, energy complementary energy liter, helps all tonics, outstanding kind receipts merit." Japan hanako materia medica ": " control the swollen and paralysis of pathogenic wind toxic, vinegar grind Fu it.Flutter damage blood stasis, lumbago kidney cold-peace Rhizoma Zingiberis Recens grinds, micro-warm, is coated with and pastes.Pained, wine vinegar takes it." Compendium of Material Medica: " Semen Sinapis Albae is pungent can enter lung, and temperature can be dispersed, therefore has the merit of the appetizing of promoting the circulation of QI eliminating phlegm, warming middle-JIAO, loose evil of bitterly subsiding a swelling, ward off." cold air can be removed, settling five organs, by the expectorant of film diaphragm, ward off stealthy gas, the addiction that disappears malaria, drop interests Dingchuan, sharp key improving eyesight, and removing blood stasis relieves the pain, and all can prove effective.Can energy dissipating fall, energy complementary energy liter, helps all tonics, outstanding kind receipts merit.
Eupolyphaga: cold in nature, salty in the mouth, enters conscience spleen three warp.The effect such as have removing blood stasis, removing mass, dredging collateral, reason wound and reunion of bone, reducing swelling and alleviating pain, stimulating milk secretion are stimulated the menstrual flow is treating blood disorders traumatology key medicine.Shennong's Herbal: " Eupolyphaga Seu Steleophaga, salty in the mouth is trembled with fear.Main trusted subordinate's cold and heat, accumulation of blood lump in the abdomen, broken heavily fortified point, hematochezia close, an eupolyphoge sinensis.Raw Chuan Ze." " Mingyi Bielu ": " give birth in east of a river Chuan Ze and sand, wet place under other wall, in soil.October adopts, suddenly and violently dry." " surgery great achievement ": " control acute gangrenous stomatitis, the tooth nose that falls collapses, unhealed of a specified duration." there is removing blood stasis, removing mass, dredging collateral, reason wound and reunion of bone, the effect such as reducing swelling and alleviating pain, stimulating milk secretion are stimulated the menstrual flow, be treating blood disorders traumatology key medicine, be applicable to the diseases such as cancer abdominal mass is gathered, amenorrhea due to stagnation of blood, postnatal blood stasis stomachache, traumatic injury, swollen and rigid tongue, congenital deformity of the tongue.Extracting solution and water extract-alcohol precipitation liquid have antithrombus formation and thrombolytic effect respectively; Extract can anticoagulant and adhesion rate, reduces aggregation number; Total alkaloids can improve cardiac muscle and brain to the tolerance of ischemia, and reduces the oxygen consumption of the heart, cerebral tissue; Decocting liquid has Regulation serum lipids, can delay atherosclerotic formation; Extract can suppress the hepatic injury caused by D-galactose and have hepatoprotective effect.
Spica Prunellae: bitter in the mouth, pungent, cold in nature, enters liver, gallbladder meridian, has and relieve inflammation or internal heat, improving eyesight, eliminating stagnation, effect of detumescence." herbal classic ": " main cold and heat, scrofula, scrofula, head sore, broken disease, loose wart stagnation of QI, swelling of the feet arthralgia chiefly caused by damp pathogen." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " liver-wind of dispelling, network of passing through, controls facial hemiparalysis.Row irritability, opens stagnation of liver-QI, only bones and muscles pain, ophthal malgia, and loose scrofula is stolen, whole body tuberculosis." have and relieve inflammation or internal heat, improving eyesight, eliminating stagnation, effect of detumescence, cures mainly conjunctival congestion and swelling pain, and order pearl nyctalgia, has a headache dizzy, scrofula, and goiter, swells and ache; Thyromegaly, tuberculous lymphadenitis, cyclomastopathy, the cards such as hypertension, hyperglycemia, hyperlipidemia and high blood viscosity, Spica Prunellae all has inhibitory action to dysentery bacterium, escherichia coli, cholera bacilli etc.The function of Spica Prunellae is liver heat removing and eyesight improving, uses stagnation resolvation tumor, also has the effect of diuretic antihypertensive.Among the peoplely to make tea with it again, do refrigerant passive summer-heat agent.
Fructus Viticis: pungent, bitter, is slightly cold; Return bladder, liver, stomach warp.Dispelling wind and heat pathogens, the clear sharp head.For anemopyretic cold headache, gingivitis, the many tear of conjunctival congestion, poor vision, has a dizzy spell.Shennong's Herbal: " bitter in the mouth is slightly cold.Cure mainly cold and heat between muscles and bones, arthralgia chiefly caused by damp pathogen, contracture, improving eyesight, hard Fructus Viticis tooth, sharp nine orifices, removes tapeworm." " medicine class on the analogy of natural things ": " and control Taiyang channel headache, dizzy vexed, except dizzy order is dark.The medicine of loose ailment said due to cold or exposure also.If the people of insufficiency of stomach-QI can not take, probably raw expectorant disease." dispelling wind and heat pathogens, the clear sharp head.For anemopyretic cold headache, gingivitis, the many tear of conjunctival congestion, poor vision, has a dizzy spell.Fructus Viticis has obvious hypotensive effect, and its hypotensive effect is relevant with the parasympathetic nervous system that excited maincenter is induced.The methanolic extract of Vitex rotundifolia fruit has inhibitory action to the reaction of mice acetic acid twisting; Also the threshold of pain of mouse hot-plate induced pain and the threshold of pain of rat carrageenan inflammatory pain can be improved; To mouse stomach, there is certain inhibitory action to the permeability of mouse peritoneal blood capillary.
Flos Chrysanthemi: cold nature, bitter in the mouth, pungent.Return liver, lung meridian.Relieving the exterior syndrome with drugs of pungent in flavor and cool in nature, heat-clearing and toxic substances removing, treatment skin ulcer of drawing out pus by applying a plaster to the affected part, heat clearing away is eliminated the phlegm, clearing away liver-fire." book on Chinese herbal medicine converges and says ": " removing blood stasis is soothing the liver, separates the loose poison of furuncle.Stagnated blood in housewife people's abdomen, the red furuncle of the capable fire-toxin of Xie Tian.Wash skin ulcer scabies, wind parasite killing can be removed again." there is effect of dispelling wind, heat clearing away, improving eyesight, removing toxic substances.The disease such as primary treatment headache, dizzy, conjunctival congestion, irritable feverish sensation of chest and heart, furuncle, toxic swelling.Modern pharmacological research shows, Flos Chrysanthemi has treatment coronary heart disease, reduces blood pressure, prevents hyperlipidemia, antibacterial, antiviral, antiinflammatory, anti-ageing multiple pharmacologically active of waiting for a long time.To staphylococcus aureus, diphtheria corynebacterium, streptococcus, bacillus pyocyaneus, puncture Shigella, influenza virus, all there is inhibitory action.To furuncle, carbuncle, erysipelas, eczema, dermatitis, anemopyretic cold, laryngopharynx swelling and pain, hypertension etc. have good curative effect.
Rhizoma Et Radix Notopterygii: acrid in the mouth, bitter, warm in nature; Enter bladder, kidney channel.Function is fallen apart exterior cold, wind-damp dispelling, sharp joint, pain relieving.Main affection of exogenous wind-cold, has a headache lossless, edema due to wind pathogen edema, sore swollen toxin." property of medicine opinion ": " control harmful wind, aphonia in silence, blood leprosy of itching, hands and feet caused by paralysis, the askew heresy of actinal surface, insensitive impediment all over more." " product remittance essence is wanted ": " main all joints being painful all over, flesh table eight winds coming from eight orientations harmful climatic factors, except new and old rheumatism, row's slough cellulitis skin ulcer." " Thunder God concoct the property of medicine solution ": " Rhizoma Et Radix Notopterygii gas belongs to clearly sun, benefaction edema caused by disorder of QI, relaxes and does not hold back, and rises and can sink, male and be apt to fall apart, and can deliver heresy, therefore sun small intestinal of starting with.Foot sun bladder is to manage urticaria, though if its function is different from Radix Angelicae Pubescentis, reality is the exterior and the interior mutually." function falls apart exterior cold, wind-damp dispelling, sharp joint, pain relieving.Main affection of exogenous wind-cold, has a headache lossless, edema due to wind pathogen edema, sore swollen toxin.For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea; External curing vitiligo, alopecia areata.Induce sweat cold expelling, expelling wind and dampness, pain relieving.Rhizoma Et Radix Notopterygii volatile oil has antiinflammatory and anti-allergic effects. and after gastric infusion, xylol dropsy of ear, carrageenin and dextran foot swelling have inhibitory action.
Radix Cynanchi Paniculati: nature and flavor: pungent, temperature.Return Liver Channel, stomach warp.Function: removing dampness of dispeling the wind, antalgesic-antipruritic.Cure mainly: for rheumatic arthralgia, stomachache distension, toothache, lumbago, injury from falling down, urticaria, eczema.Modern pharmacological research shows: Radix Cynanchi Paniculati master, containing paeonol, flavonoid glycoside and a small amount of alkaloid, has the multiple effects such as analgesia, calmness, antibacterial, blood pressure lowering, blood fat reducing.To traumatic injury, the lumbar vertebra pain of orthopedics department; The epigastric distending pain that gastritis, stomachache, gastric ulcer etc. cause all has very significant analgesic effect.
Sanguis Draxonis: sweet in the mouth, salty, property are put down.GUIXIN warp, Liver Channel.The analgesic therapy of function dissipating blood stasis, hemostasis, promoting tissue regeneration and ulcer healing.Cure mainly traumatic injury, ecchymoma due to internal injury, dysmenorrhea, postpartum stagnation is suffered from abdominal pain, continuous bleeding due to traumatic injury, scrofula, ecthyma unhealed for long time and hemorrhoid." Haiyao Bencao, Oversea Materia Medica ": " leadingly traumatic fracture damage, all pain, tonify deficiency and vim and vigour stir thorn, and interior blood trouble is gathered, and should wine clothes." analgesic therapy of function dissipating blood stasis, hemostasis, promoting tissue regeneration and ulcer healing.Cure mainly traumatic injury, ecchymoma due to internal injury, dysmenorrhea, postpartum stagnation is suffered from abdominal pain, continuous bleeding due to traumatic injury, scrofula, ecthyma unhealed for long time and hemorrhoid.Sanguis Draxonis water logging agent (1:2) has inhibitory action in various degree to multiple pathomycetes such as trichophyton, trichophyton gypseum, oidium schoenleiniis in trial operation.This product can significantly shorten plasma in rabbit recalcification time, thus increases its Blood clotting.
Caulis Spatholobi: bitter in the mouth, sweet, warm in nature, enters liver, kidney channel, enriches blood and invigorate blood circulation, regulating menstruation, effect " modern Practical Chinese medicinal " of relaxing muscles and tendons and activating QI and blood in the collateral: " be the hematonic of robustness, be applicable to anemicus neural paralysis disease, as limbs and soreness of waist and knee joint, apathetic etc.Again for menoxenia, menstruation apolipsis etc., have the effect of invigorating blood circulation analgesia." there is blood vessel dilating, enrich blood and invigorate blood circulation, regulating menstruation; effect of relaxing muscles and tendons and activating QI and blood in the collateral, have obvious inhibitory action to platelet aggregation, promote animal kidney and the total phosphorus metabolism in uterus; be mainly used in treating the menoxenia that blood deficiency has silt, limbs pain is meciless, the card such as soreness of the waist and knees, pain.
Squama Manis: salty in the mouth, cold nature; Return liver, stomach warp.Blood circulation promoting and dispersing pathogen accumulation, stimulating milk secretion of stimulating the menstrual flow, eliminating carbuncle is burst hard.Main blood stasis amenorrhea, lump in the abdomen, rheumatic arthralgia, agalactia, carbuncle, scrofula." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " control mange carbuncle poison, dispelling the stagnated QI promoting the circulation of blood, chest and diaphragm expands against gas, controls bladder hernia pain." Compendium of Material Medica: " and except intermittent fever due to phlegm cold and heat, the tetanic pain of migratory arthralgia, qualcomm meridian, lower milk, subduing inflammation, evacuation of pus blood, sensible parasite killing." blood circulation promoting and dispersing pathogen accumulation, stimulating milk secretion of stimulating the menstrual flow, eliminating carbuncle is burst hard.
Radix Saposhnikoviae: acrid in the mouth, sweet, slightly warm in nature; Enter urinary bladder channel, lung meridian, spleen channel, Liver Channel.Function expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, antipruritic.For affection of exogenous wind-cold, headache general pain, rheumatic arthralgia, joint is ached, and stomachache is had loose bowels, discharging fresh blood stool, tetanus, rubella pruritus, skin infection from the beginning of." Japan hanako materia medica ": " control wind as 36, all labor of man are bad, invigorating middle warmer benefit god, blepharitis marginalis, and arresting lacrimation and paralysis delay, tonneau the five internal organs GUAN-pulse, five kinds of strain and seven kinds of impairment, thin damage night sweat, vexed body weight, energy tranquilizing the mind, even gaseous pulse." " Changsha medicine solution ": " network of passing through, by wet excessive, gets round by bribery, and relieve the pain pain, relaxing muscles and tendons arteries and veins, stretches anxious twin, podomere of living, and plays paralysis, holds back spontaneous perspiration, night sweat, break, metrorrhagia." function expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, antipruritic.
Herba Schizonepetae: acrid in the mouth, micro-hardship, property is micro-wet; Enter lung, Liver Channel.Expelling pathogenic wind from the body surface, rash disappears skin ulcer, hemostasis." Japan hanako materia medica ": " sharp the five internal organs, removing stagnancy of indigested food and making QI downward, relieving alcoholic intoxication.Heat-dissipating of cooking is eaten and is simmered tea, and controls wind syndrome of head and antiperspirant goes out; Semen Glycines preparatum decoct control violent trauma tremble with fear." " detailed outline ": " throat, the skin ulcer that disappears swells for loose wind heat, refresh oneself.Control stiffness of the nape, black flower in order, and raw skin ulcer, cloudy ruined, spit blood, epistaxis, hematochezia, dysentery, metrorrhagia, anal fistula." main cold, fever, headache, eye itching, cough, laryngopharynx swelling and pain, measles, carbuncle, skin ulcer scabies, puerperal blood faints.For flu, headache, measles, rubella, skin infection from the beginning of.Parch to black treating hematochezia, metrorrhagia, puerperal blood faints.Herba Schizonepetae decoct has stronger antibacterial action to staphylococcus aureus and diphtheria corynebacterium.Make fever in rabbits with typhoid fever polyvalent vaccine, give Schizonepeta tenuifolia decoct or ethanol preserved material 2g/kg gavage, find that there is faint refrigeration function.Herba Schizonepetae oil can reduce normal rat body temperature; Also have sedation, Herba Schizonepetae oil (0.5ml/kg) is to rabbit gavage, and its movable minimizing as seen, limb muscle is slightly lax.Herba Schizonepetae oil can obviously extend acetylcholine and histamine mixed liquor causes the incubation period of breathing heavily to Cavia porcellus, reduces the number of animals occurring to twitch; The guinea pig tracheal smooth muscle that also can cause anti-acetylcholine or histamine is shunk; Still there is phlegm-dispelling functions.
Herba Asari: acrid in the mouth, warm in nature.Lung meridian, kidney channel, heart channel, Liver Channel, gallbladder meridian, spleen channel.Induce sweat cold expelling; Wind-expelling pain-stopping; Warming the lung to resolve fluid-retention; The therapeutic method to keep the adverse QI flowing downwards is eliminated the phlegm, sensible.Come from Shennong's Herbal, Herba Asari, the present has it everywhere, and so its place person of going out is true not as good as Hua Zhouzhe.Its root is thin and taste is extremely pungent, and therefore named says Herba Asari.Moderns are mainly with Herba Asari Forbesii when it, and Herba Asari Forbesii tells people, and the used time carefully must distinguish ear.At the beginning of the Herba Asari Forbesii spring on perennial root raw Seedling, leaf is like horseshoe-shape, and high two, three cun, stem, as wheat ligusticumic thickness, every nest has five, seven leaves or eight, nine leaves, not without branches and tendrils.With pasting raw pale reddish brown on reed head in crack between base of leaf again, its flower is seemingly shown in and loses, and pavilion is solid as large in bean, and have broken son in nest, seemingly Semen Hyoscyami, Seedling leaf is all blue or green, through frost and withered.Its root becomes nest, has like meal broom close noisy, elongated four, five cun, yellowish white.Acrid in the mouth.River, Huaihe River are exhaled as Herba Asari, with the many misuses of people, so describe mass dissipating and swelling eliminating in detail; Induce sweat cold expelling; Wind-expelling pain-stopping; Warming the lung to resolve fluid-retention; The therapeutic method to keep the adverse QI flowing downwards is eliminated the phlegm, sensible.Mastalgia swells; Cold expelling dispels the wind; Pain relieving; Warming the lung to resolve fluid-retention; Sensible.Exterior syndrome due to wind-cold; Headache, toothache; Rheumatic arthralgia; Phlegm retention cough with asthma; Nasal obstruction; Nasal sinusitis; Aphtha.For anemofrigid cold, headache, toothache, nasal obstruction nasal sinusitis, rheumatic arthralgia, phlegm retention is breathed with cough.
Radix Angelicae Sinensis: sweet, bitter, pungent, warm.Enter the heart, liver, spleen channel.Enrich blood, invigorate blood circulation, regulating menstruation, moisturize, laxation.Cure mainly menoxenia, blood deficiency or blood stasis amenorrhea, dysmenorrhoea metrorrhagia, traumatic injury, ulcer sore pain, rheumatic arthralgia, blood deficiency such as just to close at the disease.When being classified as one of tcm clinical practice Chinese medicine with the most use.Allly need nourishing blood and promoting blood circulation, no matter belong to blood disorder, deficiency syndrome, exterior syndrome and carbuncle and ulcer, all can use Radix Angelicae Sinensis.1, for gynecological's key medicine 2, for nourishing blood.3, be used for the treatment of limbs blood stasis, especially the blood stasis that causes of traumatic injury and vascular disorder or thrombosis, swelling institute pain 4, be used for the treatment of stomachache, the stomachache of deficiency and coldness of holding concurrently to stagnation of QI-blood is comparatively suitable 5, be used for the treatment of chronic carbuncle and ulcer 6, be used for the treatment of dryness of the intestine constipation.
Radix Glycyrrhizae Preparata: sweet in the mouth, property is put down, nontoxic.QI invigorating invigorating middle warmer, relieving spasm to stop pain, nourishing the lung to arrest cough, coordinating the actions of various ingredients in a prescription.Can treating disorders in five ZANG-organs six internal organs cold and heat pathogen, hard muscles and bones, longue meat, times strength, removing toxic substances, clothes are made light of one's life by commiting suicide and are prolonged life for a long time.Raw by pathogenic fire purging heat, ripe use is fallen apart exterior cold, goes pharyngalgia, except pathogenic heat, and slow healthy energy, yin nourishing blood, tonifying the spleen and stomach, lung moistening.Radix Glycyrrhizae Preparata, is longer than warming middle-JIAO, and with sweet temperature QI invigorating, relieving spasm to stop pain power is strong.Weak for insufficiency of the spleen stomach, cardiopalmus irregularly intermittent and regularly intermittent pulse etc.Modern study shows, Radix Glycyrrhizae has the effect of similar adrenocortical hormone sample.Inhibitory action is had to the gastroxia that histamine causes; And have antiacid and alleviate the effect of gastrointestinal smooth muscle spasm.In addition, Radix Glycyrrhizae also has antiinflammatory, anti-allergic effects.
Fructus Gleditsiae Abnormalis: nature and flavor are pungent salty, temperature.1. " herbal classic ": " acrid in the mouth is salty, temperature." 2. " not Lu ": " be slightly poisonous." 3. " medicineization justice ": " taste great Xin, hot in nature." 4. " Changsha medicine solution ": " acrid in the mouth is pained." return through entering lung, stomach, large intestine channel.1. Materia Medica of Decoction: " enter JUE YIN meridian." 2. " detailed outline ": " starts with lunar, Yangming Channel edema caused by disorder of QI." 3. " Thunder God concocts property of medicine solution ": " enters liver, stomach two warp." function cures mainly sensible, clearing away phlegm, searches wind, parasite killing.Control apoplexy locked mouth, wind syndrome of head, wind is chronic, sore throat, phlegm dyspnea, and feeling of fullness stagnates, and obstruction and rejection is obstructed, carbuncle, mange, tinea disease, head sore.
Lysimachia trientaloides Hemsl.: nature and flavor are " Kweiyang medicinal herbs among the people " 1.: " pungent, temperature, nontoxic." 2. " Guizhou medical herbs ": " is warm in nature, and bitter in the mouth is pungent." function cures mainly and dispels the wind, and invigorates blood circulation.Dispelling the wind and dampness pathogens arthralgia pain, hemiplegia, traumatic injury, infantile convulsion.1. " Guizhou side's medicine among the people collection ": " herb: wind dispelling is calm, dispelling the wind and dampness pathogens pain, hemiplegia." 2. " Kweiyang medicinal herbs among the people ": " root: wind dispelling promoting the circulation of blood, dispelling the wind and dampness pathogens is paralysed, infantile convulsion." 3. " medicine investigation is planted in Guizhou ": " herb: control traumatic injury, synthetism." 4. " Guizhou medical herbs ": " expelling wind and removing dampness, blood circulation promoting and blood stasis dispelling, arresting convulsion, granulation promoting."
Folium Ginkgo: concoct and remove impurity, sieve removes earth.Nature and flavor are sweet, bitter, puckery, flat.Return through GUIXIN, lung meridian.Function cures mainly astringes the lung, and relievings asthma, blood circulation promoting and blood stasis dispelling, pain relieving.For cough and asthma due to lung deficiency; Coronary heart disease, angina pectoris, hyperlipidemia.
Herba speranskiae cantonensis: under being born in the shade of low-relief terrain, in thick grass and limes marginis.The distribution ground such as south China and Sichuan.Nature and flavor " Chinese herbal medicine is commonly used in Sichuan ": " bitter, flat." 1. function cures mainly " Chinese herbal medicine is commonly used in Sichuan ": " wind-damp dispelling, the meridian dredging, disappear hard block, invigorates blood circulation, pain relieving.Control enclosed mass in abdomen, tuberculous lymphadenitis, rheumatic ostalgia, chronic consumptive disease is coughed, sore tumor." 2. " register planted by Guangxi medicine ": " enriches blood.Control cold and heat acute filthy disease, traumatic injury."
Radix Aconiti: nature and flavor are pungent, heat.1. " medicine origin ": " gas heat, taste great Xin." curing mainly secret wanting " cloud, hot in nature, acrid-sweet flavor." 2. " Dong-eui-bo-gam ": " extremely hot in nature, acrid-sweet flavor." 3. " Changsha medicine solution ": " acrid in the mouth is bitter, warm in nature." return through 1. " key medicine divides agent ": " enters thigh, the gate of vitality two warp." 2. " book on Chinese herbal medicine brief points ": " the moon, shaoyin channel of fainting of starting with." function cures mainly dispelling cold and dampness, loose ailment said due to cold or exposure, warming the meridian, and pain relieving, controls anemofrigid-damp arthralgia, severe and migratory arthralgia pain, spasm of the limbs, and hemiplegia, wind syndrome of head is had a headache, trusted subordinate's cold type of pain, carbuncle of yin nature toxic swelling.1. " pearl sac ": " cold removing wet wind numbness, arthralgia due to stagnation of blood." 2. Li Gao: " eliminating cold-damp, passes through, loose ailment said due to cold or exposure, broken all accumulation of pathogenic cold poison.It is not enough that " 3. Wang Haogu: " mends the gate of vitality, and liver-wind is empty." 4. " Wang Shi studies carefully former side ": " property is gently dredged, and warming the spleen removes wind." 5. " detailed outline ": " is supporing yang moves back the moon, and merit is slightly slow with Radix Aconiti Lateralis Preparata."
Chicken foot Radix Aconiti Kusnezoffii: Ranunculaceae Genus Delphinium L. Yunnan Herba delphinii grandiflori Delphinium yunnanense (Franch.) Franch., is used as medicine with root.Autumn excavates, and puts into lime water and soaks taking-up on the one to two, clean Calx, dry.Nature and flavor are pungent, bitter, temperature.Function cures mainly temperature three-way meridian, expelling wind and removing dampness, dispersing cold for relieving pain.For rheumatic arthritis, cold syndrome of the stomach pain, traumatic injury pain.Ecthyma is controlled in external.
Wherein, the ratio of weight and number of described raw medicinal material is: Semen Persicae 30-40 weight portion, Pheretima 5-8 weight portion, Semen Vaccariae 15-20 weight portion, Moschus 10-15 weight portion, yellow wine 10-20 weight portion, Semen Sinapis Albae 10-20 weight portion, eupolyphaga 5-8 weight portion, Spica Prunellae 15-20 weight portion, Fructus Viticis 10-20 weight portion, Flos Chrysanthemi 35-40 weight portion, Rhizoma Et Radix Notopterygii 20-25 weight portion, Radix Cynanchi Paniculati 10-20 weight portion, Sanguis Draxonis 15-20 weight portion, Caulis Spatholobi 25-30 weight portion, Squama Manis 15-20 weight portion, Radix Saposhnikoviae 10-20 weight portion, Herba Schizonepetae 20-30 weight portion, Herba Asari 5-7 weight portion, Radix Angelicae Sinensis 20-25 weight portion, Radix Glycyrrhizae Preparata 10-20 weight portion, Herba speranskiae cantonensis 20-25 weight portion, Radix Aconiti 2-5 weight portion and chicken foot Radix Aconiti Kusnezoffii 3-5 weight portion.
Wherein, also comprise Fructus Gleditsiae Abnormalis, Lysimachia trientaloides Hemsl., Folium Ginkgo, the ratio of weight and number of described raw medicinal material is: Semen Persicae 30-40 weight portion, Pheretima 5-8 weight portion, Semen Vaccariae 15-20 weight portion, Moschus 10-15 weight portion, yellow wine 10-20 weight portion, Semen Sinapis Albae 10-20 weight portion, eupolyphaga 5-8 weight portion, Spica Prunellae 15-20 weight portion, Fructus Viticis 10-20 weight portion, Flos Chrysanthemi 35-40 weight portion, Rhizoma Et Radix Notopterygii 20-25 weight portion, Radix Cynanchi Paniculati 10-20 weight portion, Sanguis Draxonis 15-20 weight portion, Caulis Spatholobi 25-30 weight portion, Squama Manis 15-20 weight portion, Radix Saposhnikoviae 10-20 weight portion, Herba Schizonepetae 20-30 weight portion, Herba Asari 5-7 weight portion, Radix Angelicae Sinensis 20-25 weight portion, Radix Glycyrrhizae Preparata 10-20 weight portion, Herba speranskiae cantonensis 20-25 weight portion, Radix Aconiti 2-5 weight portion, chicken foot Radix Aconiti Kusnezoffii 3-5 weight portion, Fructus Gleditsiae Abnormalis 20-30 weight portion, Lysimachia trientaloides Hemsl. 15-20 weight portion and Folium Ginkgo 30-35 weight portion.
Wherein, the ratio of weight and number of described raw medicinal material is: Semen Persicae 40 weight portion, Pheretima 8 weight portion, Semen Vaccariae 20 weight portion, Moschus 15 weight portion, yellow wine 20 weight portion, Semen Sinapis Albae 20 weight portion, eupolyphaga 5 weight portion, Spica Prunellae 15 weight portion, Fructus Viticis 10 weight portion, Flos Chrysanthemi 40 weight portion, Rhizoma Et Radix Notopterygii 25 weight portion, Radix Cynanchi Paniculati 20 weight portion, Sanguis Draxonis 15 weight portion, Caulis Spatholobi 30 weight portion, Squama Manis 20 weight portion, Radix Saposhnikoviae 20 weight portion, Herba Schizonepetae 30 weight portion, Herba Asari 5 weight portion, Radix Angelicae Sinensis 25 weight portion, Radix Glycyrrhizae Preparata 10 weight portion, Herba speranskiae cantonensis 20 weight portion, Radix Aconiti 2 weight portion and chicken foot Radix Aconiti Kusnezoffii 3 weight portion.
Wherein, the ratio of weight and number of described raw medicinal material is: Semen Persicae 40 weight portion, Pheretima 5 weight portion, Semen Vaccariae 20 weight portion, Moschus 15 weight portion, yellow wine 10 weight portion, Semen Sinapis Albae 20 weight portion, eupolyphaga 5 weight portion, Spica Prunellae 20 weight portion, Fructus Viticis 10 weight portion, Flos Chrysanthemi 40 weight portion, Rhizoma Et Radix Notopterygii 25 weight portion, Radix Cynanchi Paniculati 20 weight portion, Sanguis Draxonis 15 weight portion, Caulis Spatholobi 30 weight portion, Squama Manis 20 weight portion, Radix Saposhnikoviae 10 weight portion, Herba Schizonepetae 30 weight portion, Herba Asari 5 weight portion, Radix Angelicae Sinensis 25 weight portion, Radix Glycyrrhizae Preparata 20 weight portion, Herba speranskiae cantonensis 20 weight portion, Radix Aconiti 2 weight portion, chicken foot Radix Aconiti Kusnezoffii 3 weight portion, Fructus Gleditsiae Abnormalis 20 weight portion, Lysimachia trientaloides Hemsl. 15 weight portion and Folium Ginkgo 30 weight portion.
In order to solve the problems of the technologies described above, present invention also offers a kind of preparation method for the treatment of the medicine of QI and blood stagnation cerebroma, wherein, the dosage form of described medicine is decoction, and its preparation method comprises the following steps:
Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 3-6cm, soak 3-10 hour;
Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 40-80 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate a, for subsequent use;
Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 3-6cm, soaks 3-10 hour;
Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 35-55 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.
Wherein, the dosage form of described medicine is capsule, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 80 ~ 90%, reflux 2 ~ 5 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 80 ~ 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 ~ 5 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.05 ~ 0.5:0.05 ~ 0.1, incapsulate in housing, obtain capsule by described capsule 's content.
Wherein, the dosage form of described medicine is injection, and its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 97%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 80% ~ 90%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 45 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 97%,
3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 20g ~ 40g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 40 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 decoction
40 parts, Semen Persicae, Pheretima 8 parts, Semen Vaccariae 20 parts, 15 parts, Moschus, yellow wine 20 parts, Semen Sinapis Albae 20 parts, eupolyphaga 5 parts, Spica Prunellae 15 parts, Fructus Viticis 10 parts, Flos Chrysanthemi 40 parts, Rhizoma Et Radix Notopterygii 25 parts, Radix Cynanchi Paniculati 20 parts, Sanguis Draxonis 15 parts, Caulis Spatholobi 30 parts, Squama Manis 20 parts, Radix Saposhnikoviae 20 parts, Herba Schizonepetae 30 parts, Herba Asari 5 parts, Radix Angelicae Sinensis 25 parts, Radix Glycyrrhizae Preparata 10 parts, Herba speranskiae cantonensis 20 parts, Radix Aconiti 2 parts and chicken foot Radix Aconiti Kusnezoffii 3 parts;
Its preparation method comprises the following steps:
Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 6cm, soak 10 hours;
Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 80 minutes dosage to medicinal liquid be slowly 300ml, filters, obtain filtrate a, for subsequent use;
Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 6cm, soaks 10 hours;
Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 55 minutes dosage to medicinal liquid be slowly 300ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.
Embodiment 2 capsule
40 parts, Semen Persicae, Pheretima 5 parts, Semen Vaccariae 20 parts, 15 parts, Moschus, yellow wine 10 parts, Semen Sinapis Albae 20 parts, eupolyphaga 5 parts, Spica Prunellae 20 parts, Fructus Viticis 10 parts, Flos Chrysanthemi 40 parts, Rhizoma Et Radix Notopterygii 25 parts, Radix Cynanchi Paniculati 20 parts, Sanguis Draxonis 15 parts, Caulis Spatholobi 30 parts, Squama Manis 20 parts, Radix Saposhnikoviae 10 parts, Herba Schizonepetae 30 parts, Herba Asari 5 parts, Radix Angelicae Sinensis 25 parts, Radix Glycyrrhizae Preparata 20 parts, Herba speranskiae cantonensis 20 parts, Radix Aconiti 2 parts, chicken foot Radix Aconiti Kusnezoffii 3 parts, Fructus Gleditsiae Abnormalis 20 parts, Lysimachia trientaloides Hemsl. 15 parts and Folium Ginkgo 30 parts;
Preparation method comprises:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 5 times is the ethanol of 90%, reflux 5 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 5 times again, reflux 3 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.05:0.05, incapsulate in housing, obtain capsule by described capsule 's content.
Embodiment 3 injection
40 parts, Semen Persicae, Pheretima 5 parts, Semen Vaccariae 20 parts, 15 parts, Moschus, yellow wine 10 parts, Semen Sinapis Albae 20 parts, eupolyphaga 5 parts, Spica Prunellae 20 parts, Fructus Viticis 10 parts, Flos Chrysanthemi 40 parts, Rhizoma Et Radix Notopterygii 25 parts, Radix Cynanchi Paniculati 20 parts, Sanguis Draxonis 15 parts, Caulis Spatholobi 30 parts, Squama Manis 20 parts, Radix Saposhnikoviae 10 parts, Herba Schizonepetae 30 parts, Herba Asari 5 parts, Radix Angelicae Sinensis 25 parts, Radix Glycyrrhizae Preparata 20 parts, Herba speranskiae cantonensis 20 parts, Radix Aconiti 2 parts, chicken foot Radix Aconiti Kusnezoffii 3 parts, Fructus Gleditsiae Abnormalis 20 parts, Lysimachia trientaloides Hemsl. 15 parts and Folium Ginkgo 30 parts;
Its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 97%;
Second step, adding relative to the determining alcohol of the quality 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 90%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 hours under the condition of 10 DEG C, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 60 minutes at this, the micron particles of acquisition 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 97%,
3rd step, gets the mixed powder 20g that second step obtains, adds propylene glycol 40g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1gg needle-use activated carbon, fully stirs 50 minutes; Decarbonization filtering; With 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
The toxicity test of medicine
1. acute toxicity test: with the decoction of the embodiment of the present invention 1 for object, gives white mouse large enteral dispensing, observes 14 for 200 times of clinical consumption per day.The all animals of result are strong deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction.Irritation test is carried out to white mouse vagina and damaged skin, there are no irritative response and other untoward reaction.Toxicity test proves, the not toxic effect of this medicine and untoward reaction, clinical practice is safe and reliable.
2. long term toxicity test: the capsule of the embodiment of the present invention 2 is pressed 8,16 and 32g crude drug/kg continuous use 12 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 12 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Clinical data
200 routine patients are three grades are diagnosed as cerebroma patient to go to the hospital, and lose the patient of surgical engine meeting or recurrence after operation.There were 40 people at age below 20 years old, and the patient in 20-40 year has 80 people, more than 40 years old 80.Patient is divided into treatment one group first at random, treats two groups, treats three groups and matched group, often organize 50 people.Four groups of patients comparing difference not statistically significant in age, state of an illness weight, has comparability, and according to the weight out-patient treatment of the state of an illness.
Diagnostic criteria
(1) symptoms of intracranial hypertension accounts in more than 90% Patients with Brain Tumors and occurs, it shows as: 1. headache, Nausea and vomiting, headache multidigit, in forehead and temples, are the aggravation of persistent headache paroxysmal, and headache in morning of being everlasting is heavier, and the intermission can be normal.2. papilloedema and visual deterioration.3. spirit and disturbance of consciousness and other symptoms: dizziness, diplopia, temporary amaurosis, damping off, confusion, spirit uneasiness or indifferent, can epilepsy be there is, even go into a coma.4. changes of vital signs: when moderate and severe acute increased intracranial pressure, often causes breathing, pulse, slows down, and blood pressure raises.
(2) main symptom: headache feeling of fullness in the head, complexion is dark dim, blurred vision, cyanotic lips, and body of the tongue purple is dim or have ecchymosis, thready and hesitant pulse or string.
Therapeutic Method
Treat one group: this is organized 50 people and uses the decoction of embodiments of the invention 1 to treat.Every day 2 times, each 30ml is oral, and January is a course for the treatment of, and 3 courses for the treatment of are carried out in treatment.
Treat two groups: this is organized 50 people and uses the capsule of embodiments of the invention 2 to treat.Every day 2 times, each one, January is a course for the treatment of, and 3 courses for the treatment of are carried out in treatment.
Treat three groups: this is organized 50 people and uses the injection of embodiments of the invention 3 to treat.Every day 1 time, intravenous drip 100ml, January is a course for the treatment of, and 3 courses for the treatment of are carried out in treatment.
Matched group: this is organized 50 people and uses carmustine to treat.Intravenous drip, each 60-80mg, 1 time weekly, January is a course for the treatment of, and 3 courses for the treatment of are carried out in treatment.
Criterion of therapeutical effect
Clinical cure: transference cure, sign and lab testing recover normal; Effective: obviously to alleviate, but recurrence; Effective: substantially to alleviate; Invalid: without alleviating.
Therapeutic outcome
Table 1 is the therapeutic effect contrast of each group
Group Clinical cure Effective Effectively Invalid
Treat one group 45（90%） 3（6%） 1（2%） 1（2%）
Treat two groups 46（92%） 2（4%） 1（2%） 1（2%）
Treat three groups 46（92%） 2（6%） 1（2%） 1（2%）
Matched group 30（60%） 5（10%） 8（16%） 7（14%）
As can be seen from Table 1, the therapeutic effect of three treatment groups is obviously all better than matched group, it can thus be appreciated that medicine of the present invention, and treatment QI and blood stagnation cerebroma, good effect, determined curative effect.
Table 2 is the side effect contrast of each group
Group There is number in side effect Side effect occurrence rate
Treat one group 0 0
Treat two groups 0 0
Treat three groups 0 0
Matched group 10 20%
As can be seen from Table 2, not there is side effect in the patient of three treatment groups, and matched group patient occurs side effect over the course for the treatment of over the course for the treatment of. it can thus be appreciated that, medicine of the present invention, in treatment QI and blood stagnation cerebroma, treatment can not have side effects, safe and effective.
Table 3 is the time contrast of the clinical cure number treatment of each group
Group Clinical cure number 1st course for the treatment of 2nd course for the treatment of 3rd course for the treatment of
Treat one group 45 5（11.11%） 20（44.44%） 20（44.44%）
Treat two groups 46 6（13.04%） 21（45.65%） 19（41.3%）
Treat three groups 46 6（13.04%） 22（47.83%） 18（39.13%）
Matched group 30 2（6.67%） 5（16.67%） 23（76.67%）
As can be seen from Table 3, the treatment time of three treatment groups, just good than matched group at the therapeutic effect of short time.It can thus be appreciated that medicine of the present invention, in treatment QI and blood stagnation cerebroma, therapeutic effect is good, and curative effect is fast.
In sum, medicine of the present invention, in treatment QI and blood stagnation cerebroma, therapeutic effect is good, and curative effect is fast, and determined curative effect is safe and effective, without recurrence, and has no side effect.
Typical case: institute of traditional Chinese medicine of Weifang City in 2011, female, 57 years old, because acute headache, Nausea and vomiting are admitted to hospital, interval headache is positioned at forehead, is the aggravation of persistent headache paroxysmal, complexion is dark dim, blurred vision, cyanotic lips, body of the tongue is purple dim or have ecchymosis, asks about medical history headache in morning of being everlasting heavier, intermission normal, temporary amaurosis, damping off, the phenomenon such as confusion, brain CT examination, there is a high density lump 0.3x02cm under forehead skull, be diagnosed as benign encephaloma, expectant treatment.The injection of embodiment 3 is adopted to treat.Every day 1 time, intravenous drip 100ml, January is a course for the treatment of, and 3 courses for the treatment of are carried out in treatment.Later observations clinical cure, transference cure.Later stage follow-up is not recurred half a year.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (8)

1. treat the medicine of QI and blood stagnation cerebroma for one kind, it is characterized in that, described medicine comprises following raw medicinal material: Semen Persicae, Pheretima, Semen Vaccariae, Moschus, yellow wine, Semen Sinapis Albae, eupolyphaga, Spica Prunellae, Fructus Viticis, Flos Chrysanthemi, Rhizoma Et Radix Notopterygii, Radix Cynanchi Paniculati, Sanguis Draxonis, Caulis Spatholobi, Squama Manis, Radix Saposhnikoviae, Herba Schizonepetae, Herba Asari, Radix Angelicae Sinensis, Radix Glycyrrhizae Preparata, Herba speranskiae cantonensis, Radix Aconiti and chicken foot Radix Aconiti Kusnezoffii.
2. medicine according to claim 1, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Semen Persicae 30-40 weight portion, Pheretima 5-8 weight portion, Semen Vaccariae 15-20 weight portion, Moschus 10-15 weight portion, yellow wine 10-20 weight portion, Semen Sinapis Albae 10-20 weight portion, eupolyphaga 5-8 weight portion, Spica Prunellae 15-20 weight portion, Fructus Viticis 10-20 weight portion, Flos Chrysanthemi 35-40 weight portion, Rhizoma Et Radix Notopterygii 20-25 weight portion, Radix Cynanchi Paniculati 10-20 weight portion, Sanguis Draxonis 15-20 weight portion, Caulis Spatholobi 25-30 weight portion, Squama Manis 15-20 weight portion, Radix Saposhnikoviae 10-20 weight portion, Herba Schizonepetae 20-30 weight portion, Herba Asari 5-7 weight portion, Radix Angelicae Sinensis 20-25 weight portion, Radix Glycyrrhizae Preparata 10-20 weight portion, Herba speranskiae cantonensis 20-25 weight portion, Radix Aconiti 2-5 weight portion and chicken foot Radix Aconiti Kusnezoffii 3-5 weight portion.
3. medicine according to claim 1, it is characterized in that, also comprise Fructus Gleditsiae Abnormalis, Lysimachia trientaloides Hemsl., Folium Ginkgo, the ratio of weight and number of described raw medicinal material is: Semen Persicae 30-40 weight portion, Pheretima 5-8 weight portion, Semen Vaccariae 15-20 weight portion, Moschus 10-15 weight portion, yellow wine 10-20 weight portion, Semen Sinapis Albae 10-20 weight portion, eupolyphaga 5-8 weight portion, Spica Prunellae 15-20 weight portion, Fructus Viticis 10-20 weight portion, Flos Chrysanthemi 35-40 weight portion, Rhizoma Et Radix Notopterygii 20-25 weight portion, Radix Cynanchi Paniculati 10-20 weight portion, Sanguis Draxonis 15-20 weight portion, Caulis Spatholobi 25-30 weight portion, Squama Manis 15-20 weight portion, Radix Saposhnikoviae 10-20 weight portion, Herba Schizonepetae 20-30 weight portion, Herba Asari 5-7 weight portion, Radix Angelicae Sinensis 20-25 weight portion, Radix Glycyrrhizae Preparata 10-20 weight portion, Herba speranskiae cantonensis 20-25 weight portion, Radix Aconiti 2-5 weight portion, chicken foot Radix Aconiti Kusnezoffii 3-5 weight portion, Fructus Gleditsiae Abnormalis 20-30 weight portion, Lysimachia trientaloides Hemsl. 15-20 weight portion and Folium Ginkgo 30-35 weight portion.
4. medicine according to claim 1 and 2, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Semen Persicae 40 weight portion, Pheretima 8 weight portion, Semen Vaccariae 20 weight portion, Moschus 15 weight portion, yellow wine 20 weight portion, Semen Sinapis Albae 20 weight portion, eupolyphaga 5 weight portion, Spica Prunellae 15 weight portion, Fructus Viticis 10 weight portion, Flos Chrysanthemi 40 weight portion, Rhizoma Et Radix Notopterygii 25 weight portion, Radix Cynanchi Paniculati 20 weight portion, Sanguis Draxonis 15 weight portion, Caulis Spatholobi 30 weight portion, Squama Manis 20 weight portion, Radix Saposhnikoviae 20 weight portion, Herba Schizonepetae 30 weight portion, Herba Asari 5 weight portion, Radix Angelicae Sinensis 25 weight portion, Radix Glycyrrhizae Preparata 10 weight portion, Herba speranskiae cantonensis 20 weight portion, Radix Aconiti 2 weight portion and chicken foot Radix Aconiti Kusnezoffii 3 weight portion.
5. the medicine according to claim 1 or 3, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Semen Persicae 40 weight portion, Pheretima 5 weight portion, Semen Vaccariae 20 weight portion, Moschus 15 weight portion, yellow wine 10 weight portion, Semen Sinapis Albae 20 weight portion, eupolyphaga 5 weight portion, Spica Prunellae 20 weight portion, Fructus Viticis 10 weight portion, Flos Chrysanthemi 40 weight portion, Rhizoma Et Radix Notopterygii 25 weight portion, Radix Cynanchi Paniculati 20 weight portion, Sanguis Draxonis 15 weight portion, Caulis Spatholobi 30 weight portion, Squama Manis 20 weight portion, Radix Saposhnikoviae 10 weight portion, Herba Schizonepetae 30 weight portion, Herba Asari 5 weight portion, Radix Angelicae Sinensis 25 weight portion, Radix Glycyrrhizae Preparata 20 weight portion, Herba speranskiae cantonensis 20 weight portion, Radix Aconiti 2 weight portion, chicken foot Radix Aconiti Kusnezoffii 3 weight portion, Fructus Gleditsiae Abnormalis 20 weight portion, Lysimachia trientaloides Hemsl. 15 weight portion and Folium Ginkgo 30 weight portion.
6. the medicine according to any one of claim 1 to 5, is characterized in that, the dosage form of described medicine is decoction, and its preparation method comprises the following steps:
Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 3-6cm, soak 3-10 hour;
Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 40-80 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate a, for subsequent use;
Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 3-6cm, soaks 3-10 hour;
Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 35-55 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.
7. the medicine according to any one of claim 1 to 5, is characterized in that, the dosage form of described medicine is capsule, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 80 ~ 90%, reflux 2 ~ 5 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 80 ~ 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 ~ 5 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.05 ~ 0.5:0.05 ~ 0.1, incapsulate in housing, obtain capsule by described capsule 's content.
8. a preparation method for the medicine described in any one of claim 1 to 5, is characterized in that, the dosage form of described medicine is injection, and its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 97%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 80% ~ 90%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 45 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 97%,
3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 20g ~ 40g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 40 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
CN201410845355.0A 2014-12-31 2014-12-31 Medicine for treating brain tumor caused by stagnation of qi and blood, and preparation method thereof Pending CN104547381A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105687858A (en) * 2016-03-17 2016-06-22 张光辉 Traditional Chinese medicine for treating adult varicella and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101559163A (en) * 2008-04-14 2009-10-21 北京汉潮联创中药科技有限公司 Prescription of pure traditional Chinese preparation for curing cerebroma and preparation method thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101559163A (en) * 2008-04-14 2009-10-21 北京汉潮联创中药科技有限公司 Prescription of pure traditional Chinese preparation for curing cerebroma and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
钱心兰: "钱伯文诊治脑瘤的临证思路与经验", 《上海中医药杂志》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105687858A (en) * 2016-03-17 2016-06-22 张光辉 Traditional Chinese medicine for treating adult varicella and preparation method thereof

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