CN104524452A - 一种治疗月经先后无定期的中药组合物 - Google Patents

一种治疗月经先后无定期的中药组合物 Download PDF

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CN104524452A
CN104524452A CN201410798409.2A CN201410798409A CN104524452A CN 104524452 A CN104524452 A CN 104524452A CN 201410798409 A CN201410798409 A CN 201410798409A CN 104524452 A CN104524452 A CN 104524452A
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李洋
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Abstract

本发明提供了一种治疗月经先后无定期的中药组合物，它由如下重量份数的原料制备得到：伽蓝菜、大叶骨牌草、白术、白芍等，本发明能治疗月经先后无定期。

Description

一种治疗月经先后无定期的中药组合物
技术领域
本发明涉及中药技术领域，具体涉及一种治疗月经先后无定期的中药组合物及制备方法和应用。
背景技术
月经先后无定期系由肝郁肾虚，气血失调导致血海蓄溢失常，出现月经周期提前或延后7天以上而至的月经病。目前缺少有效的治疗药物。
发明内容
发明目的：为了解决上述问题，本发明的目的在于提供一种治疗月经先后无定期的中药组合物及制备方法和应用。
技术方案：本发明的目的是通过如下的方案实现的：
一种治疗月经先后无定期的中药组合物，它由如下重量份数的原料制备得到：伽蓝菜15份、大叶骨牌草12份、白术20份、白芍15份、郁金10份、神曲15份、山药18份、甘草15份、香附15份、黄芩18份、柴胡12份、蒲黄15份。
所述治疗月经先后无定期的中药组合物在制备治疗月经先后无定期的药物中的应用。
本发明中伽蓝菜为景天科植物伽蓝菜的全草。大叶骨牌草为水龙骨科星蕨属植物江南星蕨Microsorium fortune(Moore)Ching，以全草和根状茎入药。其余药物均符合药典标准或记载在中药大辞典中。
有益效果：本发明疏肝解郁、气血双补、活血化瘀、行气止痛，制得的药物能够安全有效治疗月经先后无定期。
具体实施方式
以下通过实施例形式，对本发明的上述内容再作进一步的详细说明，但不应将此理解为本发明上述主题的范围仅限于以下的实例，凡基于本发明上述内容所实现的技术均属于本发明的范围。
1.制备实施例
1.1称取伽蓝菜15g、大叶骨牌草12g、白术20g、白芍15g、郁金10g、神曲15g、山药18g、甘草15g、香附15g、黄芩18g、柴胡12g、蒲黄15g，加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，装入胶囊壳，即得符合正常成人1天用量的胶囊剂。用于治疗月经先后无定期。口服，每日分早晚两次服用。
1.2称取伽蓝菜15g、大叶骨牌草12g、白术20g、白芍15g、郁金10g、神曲15g、山药18g、甘草15g、香附15g、黄芩18g、柴胡12g、蒲黄15g，加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，加淀粉，按常规工艺制粒，即得符合正常成人1天用量的颗粒剂。用于治疗月经先后无定期。口服，每日分早晚两次服用。
1.3称取伽蓝菜15g、大叶骨牌草12g、白术20g、白芍15g、郁金10g、神曲15g、山药18g、甘草15g、香附15g、黄芩18g、柴胡12g、蒲黄15g，加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，加淀粉，按常规工艺制粒，压片，即可制得符合正常成人1天用量的片剂。用于治疗月经先后无定期。口服，每日分早晚两次服用。
2.本发明对月经先后无定期的临床研究
2.1一般资料：发明人2011年3月-2012年11月间共收集60例月经先后无定期的门诊患者，年龄18-35岁，随机分为：治疗组30例，空白组30例。两组年龄、病情等资料无显著性差异，具有可比性。
2.2诊断标准：
2.2.1月经周期或前或后，均逾7天以上，并连续2个月经周期以上。
2.2.2月经周期紊乱应与青春期、更年期月经紊乱相区别。
2.2.3妇科检查及B超等排除器质性病变。测基础体温，阴道涂片、宫颈粘液结晶检查以了解卵巢功能情况。
2.2.4证候分类
2.2.4.1肝气郁滞：月经周期不定，经量或多或少，色紫红有块，经行不畅，胸胁、乳房以及小腹胀痛，脘闷不舒，时叹息。苔薄白或薄黄，脉弦。
2.2.4.2肾气不足：月经周期不定，量少，色淡黯，质稀，神疲乏力，腰骶酸痛，头晕耳鸣。舌淡苔少，脉细尺弱。
2.3试验方法
2.3.1治疗组口服本发明按照具体实施例1.1制得的胶囊，早晚各一次。疗程15天。
2.3.2空白组口服安慰剂胶囊，早晚各一次。疗程15天。
2.4疗效标准与治疗结果
2.4.1疗效标准
痊愈：月经周期恢复正常，维持3个月以上。好转：月经周期恢复正常，但不能维持3个月以上。无效：月经周期末见变化。
2.4.2治疗统计结果见表1。
表1两组疗效比较
组别 n 痊愈 好转 无效 总有效率(％)
治疗组 30 15 9 6 80
空白组 30 2 1 27 10
可见，本发明制得的药物能够安全有效治疗月经先后无定期。
2.5典型病例
王某，女，25岁，月经周期或前或后，均逾7天以上，妇科检查及B超等排除器质性病变。经量或多或少，色紫红有块，经行不畅，胸胁、乳房以及小腹胀痛，脘闷不舒，时叹息。苔薄白或薄黄，脉弦。诊断为肝气郁滞，口服本发明按照具体实施例1.1制得的胶囊，早晚各一次，连续15天，下一个月经周期恢复正常，并维持6个月。

Claims (2)

1.一种治疗月经先后无定期的中药组合物，其特征在于，它由如下重量份数的原料制备得到：伽蓝菜15份、大叶骨牌草12份、白术20份、白芍15份、郁金10份、神曲15份、山药18份、甘草15份、香附15份、黄芩18份、柴胡12份、蒲黄15份。
2.如权利要求1所述治疗月经先后无定期的中药组合物在治疗月经先后无定期的药物中的应用。
CN201410798409.2A 2014-12-19 2014-12-19 一种治疗月经先后无定期的中药组合物 Pending CN104524452A (zh)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105456950A (zh) * 2016-01-18 2016-04-06 黄庆辉 一种治疗肝郁型月经先后无定期的中药

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
卓雨农: "《卓雨农中医妇科治疗秘诀》", 30 April 2010, 四川科学技术出版社 *
黎小斌等: "《妇科病效验秘方》", 31 July 2011, 化学工业出版社 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105456950A (zh) * 2016-01-18 2016-04-06 黄庆辉 一种治疗肝郁型月经先后无定期的中药

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Application publication date: 20150422