CN104524423A - Traditional Chinese medicine for treating depression after myocardial infarction due to liver stangation and spleen deficiency as well as preparation method thereof - Google Patents

Abstract

The invention provides a traditional Chinese medicine for treating depression after myocardial infarction due to liver stangation and spleen deficiency as well as a preparation method thereof. The traditional Chinese medicine comprises the following raw materials: radix bupleuri, Japanese polygala, Chinese angelica, white peony root, hypericum perforatum, fried atractylodes, Poria cocos, royal jelly, honey-fried licorice root, fried spine date seed, Eleutherococcus brachypus, curcuma tuber, american ginseng, Trichosanthes kirilowii Maxim, grass-leaved sweetflag rhizome, russula virescens, rhizoma cyperi, dried orange peel, Conioselinum morrisonense Hayata, cortex moutan, cape jasmine and all-grass of Tomentose Corydalis. The traditional Chinese medicine has the beneficial effect that a traditional Chinese medicine syndrome differentiation treatment principle is abided, the traditional Chinese medicine has the advantages of strong pertinency, short treatment course, fast effectiveness and difficult recurrence when the depression after myocardial infarction due to liver stangation and spleen deficiency is treated, can break the defects of large side-effect of a traditional western medicine anti-depression medicines, large adverse reaction and easy recurrence, and can overcome the disadvantage that a Chinese patent medicine can not apply medicine according to indications.

Description

A kind of Chinese medicine and preparation method for the treatment of liver-depression and spleen-insufficiency type myocardial infarction Depression

Technical field

The present invention relates to engineering of traditional Chinese medicine technical field, particularly relate to a kind of Chinese medicine and preparation method for the treatment of liver-depression and spleen-insufficiency type myocardial infarction Depression.

Background technology

Myocardial infarction retarded depression is complication common after myocardial infarction, clinical manifestation mainly contains emotion melancholy and lacks with happy feeling, and can with insomnia, the symptom such as tired, labour force declines, lose weight and pessimism is desperate, severe patient even has suicidal tendency, drastically influence therapeutic effect and the life quality of myocardial infarction patient.Think that depression is the independent hazard factor affecting myocardial infarction prognosis at present.In recent years, the anti depressant therapy of patients with depression is accompanied day by day to come into one's own after myocardial infarction clinically.

Myocardial infarction patient, due to the worry to prognosis and the fear to death, is absorbed among anxiety, pessimism, desperate emotion, easily develops into depression, have a strong impact on the treatment of disease and the life quality of patient.Many simple application oral western medicine class anti depressant medications clinically in the past, effect is undesirable, there is more side effect and untoward reaction, can not drug withdrawal suddenly etc. after having treated.

Exceeded the high incidence of depression cardiovascular and cerebrovascular disease and tumor leap to first of developed country.Because of the variation of its Symptoms, complicated, somatization, bring certain puzzlement without objectifying to the diagnosis of depression.The experience of current Diagnosis of Depression mainly by graphic diagnosis and doctor is stronger without the subjective consciousness of objective indication doctor and patient; Add that many patients are due to the prejudice active avoidance that has primary disease in understanding or deny that some symptom more brings difficulty to the correct diagnosis of primary disease.In addition a large amount of patient tosses about in bed not go to a doctor between each Internal Medicine Outpatient Departments of General Hospitals in special hospital or training clinic and causes delay to the depression state of an illness.The traditional Chinese medical science defines self complete theoretical system from diagnosing to the characteristic and advantage for the treatment of and all having self to the understanding of emotional disorder through permanent experience accumulation.Tcm syndrome differentiation and treatment depression clinical efficacy well not only can improve the total symptom of depression but also can improve the characteristic symptom produced by individual variation.The Overall View determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs that individual direct feeling individuation oneself susceptibility diagnosis persistent erection of the penis doctor is more focused in the feature Chinese medicine diagnosis dialectical according to traditional Chinese medical science differential diagnosis of diseases is with strong points.There is himself diagnostic method to the disease traditional Chinese medical science cannot diagnosed under current diagnosis technical conditions and have self full theoretical to advancing of disease evolution process.Stage is in early days controlled to the principle-method-recipe-medicines being in the depressive state modern medicine person's Traditional Chinese Medicine that still can not be diagnosed as depression and having oneself complete.

Liver-depression and spleen-insufficiency type patient main manifestations is forfeiture work and interest, thought retardation, attention can not be concentrated, action slows down, hyposexuality, weight loss.Its pathomechanism is irritability stasis, stagnation of liver-QI gram spleen, the spleen being damaged, can not the defeated cloth essence of water and grain of transporting in whole body, then there is the stagnation of liver-QI with deficiency of the spleen symptom such as the whole body weak, lack of appetite poor appetite, abdominal distention, loose stool, weight loss, fullness and distention in the chest and hypochondrium.Think by studying us, patients with depression also exists individual variation, and patient's body constitution is different, and the cause of disease is different, and the course of disease is different, and pathomechanism is also different.In the generation evolution of depressive illness, the performance of different times patient and pathogenesis are completely different, even same patient has different syndrome performances in different ill periods, the course of disease has length, the state of an illness has weight, disease has deficiency and excess, and the internal organs of getting involved are also each different to some extent, and therefore individuation determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs just seems extremely important.

Summary of the invention

Technical problem to be solved by this invention is, utilize the theory of Chinese medical science that China is traditional, a kind of Chinese medicine for the treatment of liver-depression and spleen-insufficiency type myocardial infarction Depression is provided, to treatment liver-depression and spleen-insufficiency type myocardial infarction Depression, have therapeutic effect good, have no side effect and the advantage such as relapse rate is low.

In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of liver-depression and spleen-insufficiency type myocardial infarction Depression, wherein, described Chinese medicine comprises following raw medicinal material: Radix Bupleuri, Herba Polygalae Japonicae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Herba Hyperici perforati, Rhizoma Atractylodis Macrocephalae (parched), Poria, Lac regis apis, Radix Glycyrrhizae Preparata, Semen Ziziphi Spinosae (parched), Acanthopanax brachypus, Radix Curcumae, Radix Panacis Quinquefolii, Fructus Trichosanthis, Rhizoma Acori Graminei, Russula vivesscens (Schaeff.) Franch., Rhizoma Cyperi, Pericarpium Citri Reticulatae, Yushan Rhizoma Chuanxiong, Cortex Moutan, Fructus Gardeniae and Herba Corydalis tomentellae.

Wherein, the ratio of weight and number of the various raw medicinal materials in described Chinese medicine can be preferably: Radix Bupleuri 20 ~ 30 parts, Herba Polygalae Japonicae 5 ~ 15 parts, Radix Angelicae Sinensis 20 ~ 30 parts, the Radix Paeoniae Alba 30 ~ 40 parts, Herba Hyperici perforati 10 ~ 20 parts, Rhizoma Atractylodis Macrocephalae (parched) 30 ~ 40 parts, 25 ~ 35 parts, Poria, Lac regis apis 20 ~ 30 parts, Radix Glycyrrhizae Preparata 10 ~ 20 parts, Semen Ziziphi Spinosae (parched) 35 ~ 45 parts, Acanthopanax brachypus 10 ~ 20 parts, Radix Curcumae 15 ~ 25 parts, Radix Panacis Quinquefolii 20 ~ 30 parts, Fructus Trichosanthis 10 ~ 20 parts, Rhizoma Acori Graminei 20 ~ 30 parts, Russula vivesscens (Schaeff.) Franch. 15 ~ 25 parts, Rhizoma Cyperi 10 ~ 20 parts, Pericarpium Citri Reticulatae 20 ~ 30 parts, Yushan Rhizoma Chuanxiong 5 ~ 15 parts, Cortex Moutan 20 ~ 30 parts, Fructus Gardeniae 10 ~ 20 parts and Herba Corydalis tomentellae 10 ~ 20 parts.

Wherein, the ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also be preferably: Radix Bupleuri 25 ~ 30 parts, Herba Polygalae Japonicae 5 ~ 10 parts, Radix Angelicae Sinensis 20 ~ 25 parts, the Radix Paeoniae Alba 30 ~ 35 parts, Herba Hyperici perforati 10 ~ 15 parts, Rhizoma Atractylodis Macrocephalae (parched) 35 ~ 40 parts, 30 ~ 35 parts, Poria, Lac regis apis 25 ~ 30 parts, Radix Glycyrrhizae Preparata 10 ~ 15 parts, Semen Ziziphi Spinosae (parched) 40 ~ 45 parts, Acanthopanax brachypus 15 ~ 20 parts, Radix Curcumae 15 ~ 20 parts, Radix Panacis Quinquefolii 25 ~ 30 parts, Fructus Trichosanthis 10 ~ 15 parts, Rhizoma Acori Graminei 25 ~ 30 parts, Russula vivesscens (Schaeff.) Franch. 20 ~ 25 parts, Rhizoma Cyperi 15 ~ 20 parts, Pericarpium Citri Reticulatae 20 ~ 25 parts, Yushan Rhizoma Chuanxiong 5 ~ 10 parts, Cortex Moutan 20 ~ 25 parts, Fructus Gardeniae 10 ~ 15 parts and Herba Corydalis tomentellae 10 ~ 15 parts.

Wherein, the ratio of weight and number of the various raw medicinal materials in described Chinese medicine also can be preferably: Radix Bupleuri 26 parts, Herba Polygalae Japonicae 8 parts, Radix Angelicae Sinensis 25 parts, the Radix Paeoniae Alba 34 parts, Herba Hyperici perforati 11 parts, Rhizoma Atractylodis Macrocephalae (parched) 40 parts, 32 parts, Poria, Lac regis apis 27 parts, Radix Glycyrrhizae Preparata 15 parts, Semen Ziziphi Spinosae (parched) 45 parts, Acanthopanax brachypus 16 parts, Radix Curcumae 19 parts, Radix Panacis Quinquefolii 26 parts, Fructus Trichosanthis 11 parts, Rhizoma Acori Graminei 29 parts, Russula vivesscens (Schaeff.) Franch. 21 parts, Rhizoma Cyperi 7 parts, Pericarpium Citri Reticulatae 21 parts, Yushan Rhizoma Chuanxiong 10 parts, Cortex Moutan 22 parts, Fructus Gardeniae 12 parts and Herba Corydalis tomentellae 13 parts.

Wherein, the ratio of weight and number of the various raw medicinal materials in described Chinese medicine can be preferably again: Radix Bupleuri 29 parts, Herba Polygalae Japonicae 7 parts, Radix Angelicae Sinensis 23 parts, the Radix Paeoniae Alba 31 parts, Herba Hyperici perforati 13 parts, Rhizoma Atractylodis Macrocephalae (parched) 38 parts, 34 parts, Poria, Lac regis apis 25 parts, Radix Glycyrrhizae Preparata 13 parts, Semen Ziziphi Spinosae (parched) 42 parts, Acanthopanax brachypus 18 parts, Radix Curcumae 15 parts, Radix Panacis Quinquefolii 30 parts, Fructus Trichosanthis 14 parts, Rhizoma Acori Graminei 27 parts, Russula vivesscens (Schaeff.) Franch. 22 parts, Rhizoma Cyperi 18 parts, Pericarpium Citri Reticulatae 23 parts, Yushan Rhizoma Chuanxiong 7 parts, Cortex Moutan 24 parts, Fructus Gardeniae 14 parts and Herba Corydalis tomentellae 15 parts.

Wherein, when the dosage form of described Chinese medicine is capsule, its preparation method comprises the following steps:

The first step, each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85% ~ 95%, reflux 1 ~ 3 hour, extract, filter acquisition first extracting solution, it is the ethanol of 85% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution, first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.2 ~ 0.5:0.2 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.

Wherein, when the dosage form of described Chinese medicine is injectable powder, its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 90%;

Second step, adding relative to the determining alcohol of the quality 4 ~ 6 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 90% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 50 ~ 80 hours under the condition of 5 DEG C ~ 8 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and again put into super micron mill pulverizing 150 ~ 180 minutes, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets mixed powder 100g ~ 200g that second step obtains, adds propylene glycol 350g ~ 550g, add 4000ml water for injection, stir and make it dissolve, inject water to 10000ml further, add 20g ~ 40g needle-use activated carbon again, fully stir 100 ~ 150 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

Beneficial effect of the present invention: Chinese medicine provided by the invention, follow the determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs principle of Traditional Chinese Medicine, when treating liver-depression and spleen-insufficiency type myocardial infarction Depression, pointed strong, short treating period, instant effect and the advantage not easily recurred, the doctor trained in Western medicine that can break traditions antidepressant class drug side effect is large, untoward reaction mainly with and easily recurrence defect and overcome the shortcoming that Chinese patent medicine can not realize suiting the remedy to the case.

Detailed description of the invention

The invention provides a kind of Chinese medicine for the treatment of liver-depression and spleen-insufficiency type myocardial infarction Depression, wherein, described Chinese medicine comprises following raw medicinal material: Radix Bupleuri, Herba Polygalae Japonicae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Herba Hyperici perforati, Rhizoma Atractylodis Macrocephalae (parched), Poria, Lac regis apis, Radix Glycyrrhizae Preparata, Semen Ziziphi Spinosae (parched), Acanthopanax brachypus, Radix Curcumae, Radix Panacis Quinquefolii, Fructus Trichosanthis, Rhizoma Acori Graminei, Russula vivesscens (Schaeff.) Franch., Rhizoma Cyperi, Pericarpium Citri Reticulatae, Yushan Rhizoma Chuanxiong, Cortex Moutan, Fructus Gardeniae and Herba Corydalis tomentellae.

Wherein, each raw medicinal material pharmacology is as follows:

Radix Bupleuri: bitter, is slightly cold.Return liver, gallbladder meridian.Reconciling superficies and interior, soothing the liver, yang invigorating.For cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, sub-official's prolapsus, proctoptosis." Chinese Pharmacopoeia "

Herba Polygalae Japonicae: be root and the herb of milk wort Herba Polygalae Japonicae.Latin plant animal mineral name: PolygalajaponicHoutt.Bitter in the mouth; Micro-pungent; Property is put down.Return lung, stomach, heart channel.Phlegm and relieving cough; Dissipating blood stasis stops blooding; Mind tranquilizing and the heart calming; Removing toxic substances and promoting subsidence of swelling.Main cough with copious phlegm; Traumatic injury, rheumatic arthralgia; Spit blood; Have blood in stool; Cardiopalmus; Insomnia; Laryngopharynx swelling and pain; Carbuncle skin infection; Venom." China's book on Chinese herbal medicine "

Radix Angelicae Sinensis: sweet, acrid, warm.Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down." Chinese Pharmacopoeia "

The Radix Paeoniae Alba: bitter, sour, is slightly cold.Return liver, spleen channel.Suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Dizzy for having a headache, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat." Chinese Pharmacopoeia "

Herba Hyperici perforati: be the herb of Garcinia maingayii Herba Hyperici perforati.Latin plant animal mineral name: HypericumperforatumL.Bitter in the mouth; Puckery; Property is put down; Return Liver Channel.Astringing to arrest bleeding; Regulating menstruation lactogenesis; Heat-clearing and toxic substances removing; Dampness removing.Main spitting of blood; Spit blood; Discharging fresh blood stool; Metrorrhagia; Traumatic hemorrhage; Menstruation is fried and is adjusted; Breast woman agalactia; Jaundice; Have sore throat; Conjunctival congestion and swelling pain; Urinary tract infection; The raw skin ulcer of mouth and nose; Carbuncle furuncle and phyma poison; Burn and scald." China's book on Chinese herbal medicine "

The Rhizoma Atractylodis Macrocephalae: bitter, sweet, temperature.Return spleen, stomach warp.Invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, frequent fetal movement.Rhizoma Atractylodis Macrocephalae (parched): be sprinkled into by processed with honey wheat bran in hot pot, add Rhizoma Atractylodis Macrocephalae sheet in time smoldering, fry to coke yellow, effusion burnt odor gas, take out, sieve removes processed with honey wheat bran.Every 100kg Rhizoma Atractylodis Macrocephalae sheet, with processed with honey wheat bran 10kg." Chinese Pharmacopoeia "

Poria: sweet, light is flat.GUIXIN, lung, spleen, kidney channel.Promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia." Chinese Pharmacopoeia "

Lac regis apis: sweet in the mouth; Acid; Property is put down.Return liver, spleen channel.Nourishing; Strong; The liver benefiting; Spleen invigorating.Main weak after being ill; Infantile malnutrition; Old asthenia; Leukopenia; Unresolved and chronic hepatitis; Duodenal ulcer; Bronchial asthma; Diabetes; Hematopathy; Psychosis; Anovulatory dysfunctional uterine hemorrhage; Menoxenia; Functional sterility and alopecia etc." Chinese Pharmacopoeia "

Radix Glycyrrhizae Preparata: sweet is flat.GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

Semen Ziziphi Spinosae (parched): sweet, sour is flat.Return liver, gallbladder, heart channel.Tonifying liver, mind calming, arresting sweating, promotes the production of body fluid.For restlessness of asrhenia type and insomnia, palpitation with fear dreaminess, the empty hyperhidrosis of body, Tianjin wound is thirsty.Semen Ziziphi Spinosae (parched): get clean Semen Ziziphi Spinosae, fry to heaving according to frying method (appendix II D), color is micro-to be deepened.Used time smashs to pieces." Chinese Pharmacopoeia "

Acanthopanax brachypus: be the stem of Araliaceae Acanthopanax brachypus.Latin plant animal mineral name: AcanthopanaxbrachypusHarms [Eleutherococcusbrachypus (Harms) Nakai].Replenishing QI to invigorate the spleen; Tranquilizing by nourishing the heart; Resolving depression and blood.Main Woman climacteric body void is weak; Hectic fever, insomnia; Depression is not joyous; Forgetful; Cardiopalmus; Dizzy; Headache; Arthralgia." China's book on Chinese herbal medicine "

Radix Curcumae: pungent, bitter, cold.Return liver, the heart, lung meridian.Regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.For amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, epilepsy is gone mad, jaundice dark coloured urine." Chinese Pharmacopoeia "

Radix Panacis Quinquefolii: sweet, micro-hardship is cool.GUIXIN, lung, kidney channel.Boosting qi and nourishing yin, clearing away heat and promoting production of body fluid.Lose for deficiency of vital energy the moon, interior-heat, cough with asthma expectorant blood, deficiency-heat is tired of tired, quenches one's thirst, dryness of the mouth and throat." Chinese Pharmacopoeia "

Fructus Trichosanthis: be the fruit of cucurbitaceous plant Fructus Trichosanthis.Latin plant animal mineral name: 1.TrichosantheskirilowiiMaxim.2.TrichosanthesrosthorniiH arms.Sweet in the mouth; Micro-hardship; Cold in nature.Return lung; Stomach; Large intestine channel.Removing heat-phlegm; Wide born of the same parents' eliminating stagnation; Moisturize laxation.Main cough due to lung-heat; The thoracic obstruction; Quench one's thirst; Constipation; Carbuncle sore tumefacting virus." China's book on Chinese herbal medicine "

Rhizoma Acori Graminei: pungent, bitter, temperature.GUIXIN, stomach warp.Removing dampness is whetted the appetite, eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.Not hungry for gastral cavity painful abdominal mass, a mouthful dysentery of keeping silent, coma epilepsy, forgetful deafness." Chinese Pharmacopoeia "

Russula vivesscens (Schaeff.) Franch.: be the sporophore of the green Russula of Russulaceae fungus.Latin plant animal mineral name: RussulaVirescens (Schaeff.) Fr. [Agari-cusvirescensSchaeff.].Sweet; Micro-acid; Cold in nature.Liver heat removing and eyesight improving; To regulate the flow of vital energy resolving depression.Main liver-heat conjunctival congestion; Poor vision; Women's depressing internal heat in liver; Uncomfortable in chestly not relax." China's book on Chinese herbal medicine "

Rhizoma Cyperi: pungent, micro-hardship, micro-sweet, flat.Return liver, spleen, tri-jiao channel.Promoting QI circulation for relieving depression, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea." Chinese Pharmacopoeia "

Pericarpium Citri Reticulatae: bitter, pungent, temperature.Return lung, spleen channel.Regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm." Chinese Pharmacopoeia "

Yushan Rhizoma Chuanxiong: be the rhizome of mountain, samphire Taiwan rhizome of chuanxiong.Latin plant animal mineral name: Coniosel inummorrisonenseHayata.Bitter in the mouth; Warm in nature.Loose wind; Regulate the flow of vital energy; Pain relieving.Main headache; Hypochondriac pain due to stagnation of liverQI; Abdominal distention." China's book on Chinese herbal medicine "

Cortex Moutan: be the root bark of ranunculaceae peony.Bitter, pungent, be slightly cold.GUIXIN, liver, kidney channel.Clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.For maculae caused by violent heat pathogen, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to YIN-deficiency, amenorrhea dysmenorrhea, carbuncle sore tumefacting virus, falls and flutters the pain of injury." Chinese Pharmacopoeia "

Fructus Gardeniae: bitter, cold.GUIXIN, lung, tri-jiao channel.Pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.Vexed for calentura, jaundice dark coloured urine, blood strangury and dry pain, heat in blood tells nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles; External treatment bruise pain." Chinese Pharmacopoeia "

Herba Corydalis tomentellae: come from Nanchuan " conventional Chinese herbal medicine handbook ".For the herb of creamcups hair Herba corydalis racemosae.Latin plant animal mineral name: Corydal istomentel laFranch.Bitter in the mouth; Cool in nature.Heat-clearing and toxic substances removing; Cool the blood dissipate blood stasis.Main influenza; Laryngopharynx swelling and pain; Conjunctival congestion and pain of eye; Hemoptysis; Spit blood; Gastric heat gastralgia; Hypochondriac pain due to stagnation of liverQI; Damp-heat dysentery; Carbuncle sore tumefacting virus; Treating swelling and pain by traumatic injury." China's book on Chinese herbal medicine "

Wherein, the ratio of weight and number of the various raw medicinal materials in described Chinese medicine can be preferably: Radix Bupleuri 20 ~ 30 parts, Herba Polygalae Japonicae 5 ~ 15 parts, Radix Angelicae Sinensis 20 ~ 30 parts, the Radix Paeoniae Alba 30 ~ 40 parts, Herba Hyperici perforati 10 ~ 20 parts, Rhizoma Atractylodis Macrocephalae (parched) 30 ~ 40 parts, 25 ~ 35 parts, Poria, Lac regis apis 20 ~ 30 parts, Radix Glycyrrhizae Preparata 10 ~ 20 parts, Semen Ziziphi Spinosae (parched) 35 ~ 45 parts, Acanthopanax brachypus 10 ~ 20 parts, Radix Curcumae 15 ~ 25 parts, Radix Panacis Quinquefolii 20 ~ 30 parts, Fructus Trichosanthis 10 ~ 20 parts, Rhizoma Acori Graminei 20 ~ 30 parts, Russula vivesscens (Schaeff.) Franch. 15 ~ 25 parts, Rhizoma Cyperi 10 ~ 20 parts, Pericarpium Citri Reticulatae 20 ~ 30 parts, Yushan Rhizoma Chuanxiong 5 ~ 15 parts, Cortex Moutan 20 ~ 30 parts, Fructus Gardeniae 10 ~ 20 parts and Herba Corydalis tomentellae 10 ~ 20 parts.

Wherein, the ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also be preferably: Radix Bupleuri 25 ~ 30 parts, Herba Polygalae Japonicae 5 ~ 10 parts, Radix Angelicae Sinensis 20 ~ 25 parts, the Radix Paeoniae Alba 30 ~ 35 parts, Herba Hyperici perforati 10 ~ 15 parts, Rhizoma Atractylodis Macrocephalae (parched) 35 ~ 40 parts, 30 ~ 35 parts, Poria, Lac regis apis 25 ~ 30 parts, Radix Glycyrrhizae Preparata 10 ~ 15 parts, Semen Ziziphi Spinosae (parched) 40 ~ 45 parts, Acanthopanax brachypus 15 ~ 20 parts, Radix Curcumae 15 ~ 20 parts, Radix Panacis Quinquefolii 25 ~ 30 parts, Fructus Trichosanthis 10 ~ 15 parts, Rhizoma Acori Graminei 25 ~ 30 parts, Russula vivesscens (Schaeff.) Franch. 20 ~ 25 parts, Rhizoma Cyperi 15 ~ 20 parts, Pericarpium Citri Reticulatae 20 ~ 25 parts, Yushan Rhizoma Chuanxiong 5 ~ 10 parts, Cortex Moutan 20 ~ 25 parts, Fructus Gardeniae 10 ~ 15 parts and Herba Corydalis tomentellae 10 ~ 15 parts.

Wherein, the ratio of weight and number of the various raw medicinal materials in described Chinese medicine also can be preferably: Radix Bupleuri 26 parts, Herba Polygalae Japonicae 8 parts, Radix Angelicae Sinensis 25 parts, the Radix Paeoniae Alba 34 parts, Herba Hyperici perforati 11 parts, Rhizoma Atractylodis Macrocephalae (parched) 40 parts, 32 parts, Poria, Lac regis apis 27 parts, Radix Glycyrrhizae Preparata 15 parts, Semen Ziziphi Spinosae (parched) 45 parts, Acanthopanax brachypus 16 parts, Radix Curcumae 19 parts, Radix Panacis Quinquefolii 26 parts, Fructus Trichosanthis 11 parts, Rhizoma Acori Graminei 29 parts, Russula vivesscens (Schaeff.) Franch. 21 parts, Rhizoma Cyperi 7 parts, Pericarpium Citri Reticulatae 21 parts, Yushan Rhizoma Chuanxiong 10 parts, Cortex Moutan 22 parts, Fructus Gardeniae 12 parts and Herba Corydalis tomentellae 13 parts.

Wherein, the ratio of weight and number of the various raw medicinal materials in described Chinese medicine can be preferably again: Radix Bupleuri 29 parts, Herba Polygalae Japonicae 7 parts, Radix Angelicae Sinensis 23 parts, the Radix Paeoniae Alba 31 parts, Herba Hyperici perforati 13 parts, Rhizoma Atractylodis Macrocephalae (parched) 38 parts, 34 parts, Poria, Lac regis apis 25 parts, Radix Glycyrrhizae Preparata 13 parts, Semen Ziziphi Spinosae (parched) 42 parts, Acanthopanax brachypus 18 parts, Radix Curcumae 15 parts, Radix Panacis Quinquefolii 30 parts, Fructus Trichosanthis 14 parts, Rhizoma Acori Graminei 27 parts, Russula vivesscens (Schaeff.) Franch. 22 parts, Rhizoma Cyperi 18 parts, Pericarpium Citri Reticulatae 23 parts, Yushan Rhizoma Chuanxiong 7 parts, Cortex Moutan 24 parts, Fructus Gardeniae 14 parts and Herba Corydalis tomentellae 15 parts.

Wherein, when the dosage form of described Chinese medicine is capsule, its preparation method comprises the following steps:

The first step, each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85% ~ 95%, reflux 1 ~ 3 hour, extract, filter acquisition first extracting solution, it is the ethanol of 85% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution, first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.2 ~ 0.5:0.2 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.

Wherein, when the dosage form of described Chinese medicine is injectable powder, its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 90%;

Second step, adding relative to the determining alcohol of the quality 4 ~ 6 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 90% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 50 ~ 80 hours under the condition of 5 DEG C ~ 8 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and again put into super micron mill pulverizing 150 ~ 180 minutes, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets mixed powder 100g ~ 200g that second step obtains, adds propylene glycol 350g ~ 550g, add 4000ml water for injection, stir and make it dissolve, inject water to 10000ml further, add 20g ~ 40g needle-use activated carbon again, fully stir 100 ~ 150 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1: capsule prepared by the present invention

Get Radix Bupleuri 290g, Herba Polygalae Japonicae 70g, Radix Angelicae Sinensis 230g, Radix Paeoniae Alba 310g, Herba Hyperici perforati 130g, Rhizoma Atractylodis Macrocephalae (parched) 380g, Poria 340g, Lac regis apis 250g, Radix Glycyrrhizae Preparata 130g, Semen Ziziphi Spinosae (parched) 420g, Acanthopanax brachypus 180g, Radix Curcumae 150g, Radix Panacis Quinquefolii 300g, Fructus Trichosanthis 140g, Rhizoma Acori Graminei 270g, Russula vivesscens (Schaeff.) Franch. 220g, Rhizoma Cyperi 180g, Pericarpium Citri Reticulatae 230g, Yushan Rhizoma Chuanxiong 70g, Cortex Moutan 240g, Fructus Gardeniae 140g and Herba Corydalis tomentellae 150g;

Its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 times is the ethanol of 90%, reflux 3 hours, extracts, and filters acquisition first extracting solution, it is the ethanol of 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, during reflux 2, extract, filter acquisition second extracting solution, first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, sieve, obtain 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.4:0.3, incapsulate in housing by described capsule 's content, obtain capsule finished product.

Embodiment 2: injectable powder prepared by the present invention

Get Radix Bupleuri 260g, Herba Polygalae Japonicae 80g, Radix Angelicae Sinensis 250g, Radix Paeoniae Alba 340g, Herba Hyperici perforati 110g, Rhizoma Atractylodis Macrocephalae (parched) 400g, Poria 320g, Lac regis apis 270g, Radix Glycyrrhizae Preparata 150g, Semen Ziziphi Spinosae (parched) 450g, Acanthopanax brachypus 160g, Radix Curcumae 190g, Radix Panacis Quinquefolii 260g, Fructus Trichosanthis 110g, Rhizoma Acori Graminei 290g, Russula vivesscens (Schaeff.) Franch. 210g, Rhizoma Cyperi 70g, Pericarpium Citri Reticulatae 210g, Yushan Rhizoma Chuanxiong 100g, Cortex Moutan 220g, Fructus Gardeniae 120g and Herba Corydalis tomentellae 130g;

Its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 4 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 90%;

Second step, adding relative to the determining alcohol of the quality 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 90%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 70 hours under the condition of 6 DEG C, adopt percolation with the speed of 1ml per minute slowly percolation, collect percolate, concentrated and dry, and again put into super micron mill pulverizing 160 minutes, the micron particles of acquisition 0.5 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets the mixed powder 150g that second step obtains, adds propylene glycol 450g, add 4000ml water for injection, stirs and makes it dissolve, inject water to 10000ml further, then add 35g needle-use activated carbon, fully stirs 130 minutes; Decarbonization filtering; With 0.22 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

Toxicity test:

Acute toxicity test: injectable powder prepared by the capsule prepared with the embodiment of the present invention 1, embodiment 2 is dissolved in distilled water respectively, gives 2 groups of white mice feeding dispensings or wiping respectively with 160 of clinical consumption per day times and 240 times, observes 7; The all white mice of result are strong deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction.Irritation test is carried out to white mouse oral cavity and damaged skin, there are no irritative response and other untoward reaction.

Long term toxicity test: the injectable powder prepared of the capsule that the embodiment of the present invention 1 is prepared and embodiment 2 respectively to mice by 7.81, 18.34 and 40.11g crude drug/kg be dissolved in water, continuous uses 12 weeks are distinguished to 6 groups of mices, every day 2 times, and drug withdrawal is after 4 weeks, result shows: Chinese medicine of the present invention is to the hair of 6 groups of test mices, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, the indexs such as blood fat all have no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 12 weeks and drug withdrawal are after 4 weeks, Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: in June, 2011-2013 year October my Out-patient Department and the myocardial infarction of being in hospital after accompany patients with depression 112 example, 46-79 years old ages, wherein, male 78 example, women 34 example.Be divided into treatment group and matched group at random.Treatment group 56 example, 46 ~ 77 years old age, male 40 example, women 16 example; Matched group 56 example, 47 ~ 79 years old age, male 38 example, women 18 example.

Diagnostic criteria:

Western medicine diagnose standard: with reference to calendar year 2001 Chinese Medical Association's psychiatric department association " Chinese Spirit classification of diseases scheme and diagnostic criteria " the 3rd edition (CCMD-3) as diagnostic criteria.24 conduct evaluation instruments of self rating depressive scale (SDS), HAMD depression scale, total score >=20 point are selected in.Symptom standard: low based on mental state, and have at least following 4 (symptoms): 1. hebetude, without happy sense; 2. energy goes down or tired sense; 3. psychomotor activity is sluggish or intense; 4. self evaluation too low, feel guilty or have feeling of guilt; 5. association difficulty or conscious elaborative faculty decline; 6. occur wanting to die thought or suicide, autolesionism repeatedly; 7. sleep disorder, as insomnia, early awakening or hypersomnia; 8. appetite reduction or body weight obviously alleviate; 9. hyposexuality.Course of disease standard: meet symptom standard and at least continue 2 weeks.

Tcm diagnosis standard: the diagnostic criteria that " combination of Chinese and Western medicine differentiation of symptoms and signs for classification of syndrome standard of hot-tempered melancholia " formulated with reference to the Kunming meeting in 1991 of psychosis Professional Committee of CAIM (Chinese Association Of Integrative Medicine) and country's " 15 " key scientific and technological projects " research of depression treatment law " set up, diagnoses in conjunction with clinical experience.Syndrome of stagnation of liver qi and spleen deficiency diagnostic criteria: (1) mental symptom: be in a very depressed state, pessimistic and worldweary; Sentimentality; Insomnia and dreamful sleep; Kind sigh; Action minimizing or fidgets due to deficiency are not peaceful; (2) somatization: (1) both sides of the chest distension; Abdominal distention and pain is let out; Body is tired indigestion and loss of appetite; Body of the tongue is light red or in vain light, white and thin fur; Thready and rapid pulse or heavy thin; Have in mental symptom and be in a very depressed state, and other at least two; There is in somatization both sides of the chest distension, and other at least one items.

Inclusive criteria: the age at 18 ~ 80 years old, male or female; Meet diagnostic criteria and the Syndrome Differentiation of Traditional Chinese Medicine standard of doctor trained in Western medicine; Signature Informed Consent Form.

Exclusion standard: get rid of organic mental disorders, or ergasia material and dependent/non-dependent material Depression Induced; Get rid of serious cerebrovascular and the serious organic illness of brain; Get rid of and be associated with serious liver, kidney illness (Decompensated stage) person.Get rid of serious cardiac disorder, comprise cardiac insufficiency (cardiac function must not lower than II grade), unstable angina pectoris, Patients With Rheumatic Valvular Disease.

Criterion of therapeutical effect: according to HAMD (24) scoring, total score <8 is normal; 8 ~ 20 is minor depressive; 21 ~ 34 is modest depression; >=35 is severe depression; Respectively before medication, medication 2,4 has no each after 6 weeks mensuration 1 time, and at the end of the course for the treatment of, evaluates HAMD deduction rate.Depression effects presses HAMD deduction rate standard [before deduction rate=(before treatment the rear HAMD value of HAMD value-treatment)/treatment HAMD value × 100%]: recovery from illness: deduction rate >=90%; Effective: deduction rate 60 ~ 89%; Take a turn for the better: 30 ~ 59%; Invalid: <30%.

Therapeutic Method:

The capsule medicine of the oral embodiment of the present invention 1 for the treatment of group, every day is early, middle and late respectively takes 1 time, each 3.It within 6 weeks, is a course for the treatment of.

Matched group takes deanxit (Ling Bei pharmaceutical Co. Ltd of Denmark, Flupentixol and Melitracen Tablets), and morning every day, noon respectively take a slice, and the dosage in several cases morning can add to 2, within 6 weeks, is a course for the treatment of.Adopt one day a slice, one day half, the drug withdrawal gradually of two and half sheet modes after 6 weeks.

Therapeutic outcome: two groups of patients who suffered with depression clinical efficacy statistics, in table 1; The HAMD integration change statistics of two groups of patients, in table 2.

Table 1 liang group patients who suffered with depression Comparison of therapeutic (example/%)

Group	Number of cases n	Recovery from illness	Effective	Take a turn for the better	Invalid	Effectively total
							Treatment group	56	11	16	26	3	53/94.6％
Matched group	56	4	17	24	11	45/80.4％

Table 2 liang group patient HAMD integration change

Group	Before treatment	After treating 2 weeks	After treating 4 weeks	After treating 6 weeks
					Treatment group	24.16±2.61	22.72±3.28	19.41±2.58	10.84±5.19
Matched group	23.96±2.47	22.73±3.85	20.58±3.65	13.74±6.13

Untoward reaction: two groups over the course for the treatment of, and treatment group is without any untoward reaction., there are dizzy 4 examples, xerostomia 7 example, sleep disorder 8 example in matched group, 2 examples of trembling, uneasy 2 examples, restless 1 example, constipation 2 example etc.

Recurrence: carry out following the tracks of half a year to two groups of recoveries from illness and effective patient and follow up a case by regular visits to, every month, check once evaluated HAMD, calculated HAMD deduction rate after half a year.Treatment group: 11 patients of recovery from illness, without recurring, HAMD scoring is substantially unchanged, and the reduction of deduction rate is no more than 2%, and 16 effective patients, recur 1 people, and HAMD scoring change is less, and average deduction rate reduction is no more than 5%; Matched group: 4 patients of recovery from illness, 1 people's recurrence, HAMD scoring change is less, and average deduction rate reduces about 8%, and 17 effective patients, recur 4 people, and HAMD scoring changes greatly, and average deduction rate reduces about 19%.

Model case: beam, man, 56 years old, there is long-term smoking history, because feeling of oppression and pain in the chest is admitted to hospital, after electrocardiogram and myocardium enzyme etc. check, be diagnosed as acute inferior, right ventricle infarction, because patient is older, and myocardial infarction degree is heavier, myocardial ischemia scope is larger, exist and sudden cardiac arrest occurs, malignant arrhythmia, cardiogenic shock etc. may, larger pressure is caused to patients ' psychological, in therapeutic process, worry to prognosis and the fear to death, it is made to be absorbed in anxiety, pessimistic, among desperate emotion, be in a very depressed state, pessimistic and worldweary, insomnia and dreamful sleep, kind sigh, fidgets due to deficiency is not peaceful, both sides of the chest distension, body is tired indigestion and loss of appetite, pale tongue, white and thin fur, be diagnosed as liver-depression and spleen-insufficiency type depression, HAMD scoring is 56.23, take the capsule of the embodiment of the present invention 1, every day early, in, evening respectively takes 1 time, each 3, mixing in water for oral taking, after taking medicine 2 weeks, the not peaceful symptom of insomnia and fidgets due to deficiency obviously alleviates, body of the tongue recovers normal, after 4 weeks, emotion is clearly better, sigh and obviously reduce, both sides of the chest distension also obviously alleviates, continue to take after 5 weeks, both sides of the chest distension disappears substantially, emotion is good, sleep improves greatly, positive cooperation medical treatment, all the other all diseases also all disappear, continue to take 1 week consolidate curative effect, drug withdrawal, HAMD scoring is 4.72, depression is followed up a case by regular visits to and is not recurred half a year.

All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (9)

1. treat a Chinese medicine for liver-depression and spleen-insufficiency type myocardial infarction Depression, it is characterized in that, described Chinese medicine comprises following raw medicinal material: Radix Bupleuri, Herba Polygalae Japonicae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Herba Hyperici perforati, Rhizoma Atractylodis Macrocephalae (parched), Poria, Lac regis apis, Radix Glycyrrhizae Preparata, Semen Ziziphi Spinosae (parched), Acanthopanax brachypus, Radix Curcumae, Radix Panacis Quinquefolii, Fructus Trichosanthis, Rhizoma Acori Graminei, Russula vivesscens (Schaeff.) Franch., Rhizoma Cyperi, Pericarpium Citri Reticulatae, Yushan Rhizoma Chuanxiong, Cortex Moutan, Fructus Gardeniae and Herba Corydalis tomentellae.

2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of the various raw medicinal materials in described Chinese medicine is: Radix Bupleuri 20 ~ 30 parts, Herba Polygalae Japonicae 5 ~ 15 parts, Radix Angelicae Sinensis 20 ~ 30 parts, the Radix Paeoniae Alba 30 ~ 40 parts, Herba Hyperici perforati 10 ~ 20 parts, Rhizoma Atractylodis Macrocephalae (parched) 30 ~ 40 parts, 25 ~ 35 parts, Poria, Lac regis apis 20 ~ 30 parts, Radix Glycyrrhizae Preparata 10 ~ 20 parts, Semen Ziziphi Spinosae (parched) 35 ~ 45 parts, Acanthopanax brachypus 10 ~ 20 parts, Radix Curcumae 15 ~ 25 parts, Radix Panacis Quinquefolii 20 ~ 30 parts, Fructus Trichosanthis 10 ~ 20 parts, Rhizoma Acori Graminei 20 ~ 30 parts, Russula vivesscens (Schaeff.) Franch. 15 ~ 25 parts, Rhizoma Cyperi 10 ~ 20 parts, Pericarpium Citri Reticulatae 20 ~ 30 parts, Yushan Rhizoma Chuanxiong 5 ~ 15 parts, Cortex Moutan 20 ~ 30 parts, Fructus Gardeniae 10 ~ 20 parts and Herba Corydalis tomentellae 10 ~ 20 parts.

3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of the various raw medicinal materials in described Chinese medicine is: Radix Bupleuri 25 ~ 30 parts, Herba Polygalae Japonicae 5 ~ 10 parts, Radix Angelicae Sinensis 20 ~ 25 parts, the Radix Paeoniae Alba 30 ~ 35 parts, Herba Hyperici perforati 10 ~ 15 parts, Rhizoma Atractylodis Macrocephalae (parched) 35 ~ 40 parts, 30 ~ 35 parts, Poria, Lac regis apis 25 ~ 30 parts, Radix Glycyrrhizae Preparata 10 ~ 15 parts, Semen Ziziphi Spinosae (parched) 40 ~ 45 parts, Acanthopanax brachypus 15 ~ 20 parts, Radix Curcumae 15 ~ 20 parts, Radix Panacis Quinquefolii 25 ~ 30 parts, Fructus Trichosanthis 10 ~ 15 parts, Rhizoma Acori Graminei 25 ~ 30 parts, Russula vivesscens (Schaeff.) Franch. 20 ~ 25 parts, Rhizoma Cyperi 15 ~ 20 parts, Pericarpium Citri Reticulatae 20 ~ 25 parts, Yushan Rhizoma Chuanxiong 5 ~ 10 parts, Cortex Moutan 20 ~ 25 parts, Fructus Gardeniae 10 ~ 15 parts and Herba Corydalis tomentellae 10 ~ 15 parts.

4. Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of the various raw medicinal materials in described Chinese medicine is: Radix Bupleuri 26 parts, Herba Polygalae Japonicae 8 parts, Radix Angelicae Sinensis 25 parts, the Radix Paeoniae Alba 34 parts, Herba Hyperici perforati 11 parts, Rhizoma Atractylodis Macrocephalae (parched) 40 parts, 32 parts, Poria, Lac regis apis 27 parts, Radix Glycyrrhizae Preparata 15 parts, Semen Ziziphi Spinosae (parched) 45 parts, Acanthopanax brachypus 16 parts, Radix Curcumae 19 parts, Radix Panacis Quinquefolii 26 parts, Fructus Trichosanthis 11 parts, Rhizoma Acori Graminei 29 parts, Russula vivesscens (Schaeff.) Franch. 21 parts, Rhizoma Cyperi 7 parts, Pericarpium Citri Reticulatae 21 parts, Yushan Rhizoma Chuanxiong 10 parts, Cortex Moutan 22 parts, Fructus Gardeniae 12 parts and Herba Corydalis tomentellae 13 parts.

5. Chinese medicine as described in Claims 1-4, is characterized in that, the ratio of weight and number of the various raw medicinal materials in described Chinese medicine is: Radix Bupleuri 29 parts, Herba Polygalae Japonicae 7 parts, Radix Angelicae Sinensis 23 parts, the Radix Paeoniae Alba 31 parts, Herba Hyperici perforati 13 parts, Rhizoma Atractylodis Macrocephalae (parched) 38 parts, 34 parts, Poria, Lac regis apis 25 parts, Radix Glycyrrhizae Preparata 13 parts, Semen Ziziphi Spinosae (parched) 42 parts, Acanthopanax brachypus 18 parts, Radix Curcumae 15 parts, Radix Panacis Quinquefolii 30 parts, Fructus Trichosanthis 14 parts, Rhizoma Acori Graminei 27 parts, Russula vivesscens (Schaeff.) Franch. 22 parts, Rhizoma Cyperi 18 parts, Pericarpium Citri Reticulatae 23 parts, Yushan Rhizoma Chuanxiong 7 parts, Cortex Moutan 24 parts, Fructus Gardeniae 14 parts and Herba Corydalis tomentellae 15 parts.

6. Chinese medicine as described in claim 1 to 5, is characterized in that, when the dosage form of described Chinese medicine is capsule, its preparation method comprises the following steps:

The first step, each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85% ~ 95%, reflux 1 ~ 3 hour, extract, filter acquisition first extracting solution, it is the ethanol of 85% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution, first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.2 ~ 0.5:0.2 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.

7. Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is injectable powder, and its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 90%;

Second step, adding relative to the determining alcohol of the quality 4 ~ 6 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 90% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 50 ~ 80 hours under the condition of 5 DEG C ~ 8 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and again put into super micron mill pulverizing 150 ~ 180 minutes, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets mixed powder 100g ~ 200g that second step obtains, adds propylene glycol 350g ~ 550g, add 4000ml water for injection, stir and make it dissolve, inject water to 10000ml further, add 20g ~ 40g needle-use activated carbon again, fully stir 100 ~ 150 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

8. the preparation method of Chinese medicine as described in claim 1 to 5, it is characterized in that, the dosage form of described Chinese medicine is capsule, and it comprises the following steps:

The first step, each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85% ~ 95%, reflux 1 ~ 3 hour, extract, filter acquisition first extracting solution, it is the ethanol of 85% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution, first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.2 ~ 0.5:0.2 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.

9. the preparation method of Chinese medicine as described in claim 1 to 5, it is characterized in that, the dosage form of described Chinese medicine is injectable powder, and its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 90%;

Second step, adding relative to the determining alcohol of the quality 4 ~ 6 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 90% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 50 ~ 80 hours under the condition of 5 DEG C ~ 8 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and again put into super micron mill pulverizing 150 ~ 180 minutes, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets mixed powder 100g ~ 200g that second step obtains, adds propylene glycol 350g ~ 550g, add 4000ml water for injection, stir and make it dissolve, inject water to 10000ml further, add 20g ~ 40g needle-use activated carbon again, fully stir 100 ~ 150 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.