CN104524419A

CN104524419A - Traditional Chinese medicine preparation for treating gout

Info

Publication number: CN104524419A
Application number: CN201510022396.4A
Authority: CN
Inventors: 李华南; 陈浩
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-01-16
Filing date: 2015-01-16
Publication date: 2015-04-22

Abstract

The invention discloses a traditional Chinese medicine preparation for treating gout. The traditional Chinese medicine preparation comprises monarch drugs, ministerial drugs and adjuvant drugs, wherein the monarch drugs include the following components in parts by weight: 10-30 parts of bighead atractylodes rhizome and 10-30 parts of rhizoma atractylodis; the ministerial drugs include 10-30 parts of semen coicis, 10-20 parts of golden cypress, 10-30 parts of medicinal cyathula root and 10-30 parts of amomum cardamomum; and the adjuvant drug include 3-9 parts of edible tulip, 10-30 parts of rhizoma smilacis glabrae and 10-15 parts of yam rhizome. The traditional Chinese medicine preparation disclosed by the invention adopts natural plant medicines and does not comprise mineral drugs, and each traditional Chinese medicine refers to a clinical common medicine. According to clinical verification for thousands of years, the traditional Chinese medicine preparation is low in price, does not have any toxic or side effect, does not contain sugar and can be taken by patients for a long time. Therefore, the traditional Chinese medicine preparation is high in compliance.

Description

A kind of Chinese medicine preparation for the treatment of gout

Technical field

The present invention relates to a kind of Chinese medicine preparation, particularly relate to a kind of Chinese medicine preparation for the treatment of gout.

Background technology

The south of the River has a humid climate sultry, and common people's ferritic wets more, and pungent product are taken the photograph in happiness, and modern life the whirl of society is frequent in addition, takes in high purine, higher fatty acidly to increase, most easy damaged taste, causes water to wet transporting obstacle.Gouty arthritis is the too high a kind of metabolic disease causing urate crystal to be deposited on joint of serum Uric Acid Concentration that disorders of purine metabolism causes, typical acute gouty arthritis mostly is monarthritis, site of pathological change with the first sole of the foot Zhi Ji Hallux toe joint is common, current doctor trained in Western medicine still lacks etiological treatment and radical cure measure to primary disease, main with non-steroidal anti-inflammatory drugs, selective depressant, steroid, Colchicine, thyroliberin and people's anti-Interleukin-1β monoclonal antibody are main, long-term taking all classes medicine can produce various untoward reaction to body, therefore be restricted in clinical practice.

Summary of the invention

In order to overcome in prior art, the large and defect that can not effect a radical cure of the pharmaceutical preparation side effect for the treatment of gout, provides a kind of Chinese medicine preparation for the treatment of gout.

The present invention is realized by following proposal:

Treat a Chinese medicine preparation for gout, this Chinese medicine preparation comprises monarch drug, ministerial drug and adjuvant drug, and in mass parts, described monarch drug comprises: Rhizoma Atractylodis Macrocephalae 10-30 part, Rhizoma Atractylodis 10-30 part; Described ministerial drug comprises Semen Coicis 10-30 part, Cortex Phellodendri 10-20 part, Radix Cyathulae 10-30 part, Fructus Amomi Rotundus 10-30 part; Described adjuvant drug comprises Pseudobulbus Cremastrae Seu Pleiones 3-9 part, Rhizoma Smilacis Glabrae 10-30 part, Rhizoma Dioscoreae Septemlobae 10-15 part.

In mass parts, described adjuvant drug also comprises Herba Taraxaci 10-15 part, Herba Lysimachiae 10-15 part or Herba Plantaginis 10-30 part.

In mass parts, described adjuvant drug also comprises Rhizoma Paridis 10-15 part or Caulis Sinomenii 10-15 part.

In mass parts, described adjuvant drug also comprises Radix Cynanchi Paniculati 10-15 part.

In mass parts, described adjuvant drug also comprises Radix Astragali 10-30 part, Radix Codonopsis 10-15 part, Pericarpium Citri Reticulatae 10-15 part, Poria 10-15 part, Rhizoma Dioscoreae 10-30 part, Fructus Amomi 10-15 part.

In mass parts, described adjuvant drug also comprises Radix Astragali 10-30 part, Radix Codonopsis 10-15 part, Pericarpium Citri Reticulatae 10-15 part, Cortex Cinnamomi 3-10 part, Rhizoma Cibotii 6-15 part.

In mass parts, described adjuvant drug also comprises Radix Astragali 10-30 part, Radix Codonopsis 10-15 part, Pericarpium Citri Reticulatae 10-15 part, Radix Bupleuri 6-15 part, Radix Curcumae 6-15 part.

In mass parts, described adjuvant drug also comprises Radix Astragali 10-30 part, Radix Codonopsis 10-15 part, Pericarpium Citri Reticulatae 10-15 part, Radix Angelicae Sinensis 6-15 part, Rhizoma Chuanxiong 6-15 part, Radix Salviae Miltiorrhizae 6-15 part.

In mass parts, described adjuvant drug also comprises Radix Astragali 10-30 part, Radix Codonopsis 10-15 part, Pericarpium Citri Reticulatae 10-15 part, Radix Scutellariae 6-10 part, Rhizoma Coptidis 6-10 part, Herba Hedyotidis Diffusae 10-30 part.

In mass parts, described adjuvant drug also comprises Radix Astragali 10-30 part, Radix Codonopsis 10-15 part, Pericarpium Citri Reticulatae 10-15 part, Scolopendra 1-2 part, Pheretima 6-10 part, Caulis Spatholobi 10-30 part.

Beneficial effect of the present invention is:

1. Chinese medicine preparation of the present invention adopts natural plant kind medicine, and without mineral substance medicine, each taste Chinese medicine is clinical Common drugs, experiences the clinical verification of thousands of years, and cheap, has no side effect, and does not contain saccharide, and patient can long-term taking, therefore compliance is higher;

2. Chinese medicine preparation safety of the present invention is high, has no side effect, can clearing away heat and eliminating dampness, and replenishing QI to invigorate the spleen, effectively can treat acute and chronic urarthritis, and is sugar free granule, and diabetics also can be taken.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further described:

Embodiment 1

Treat a Chinese medicine preparation for gout, this Chinese medicine preparation comprises monarch drug, ministerial drug and adjuvant drug, and in quality g, described monarch drug comprises: Rhizoma Atractylodis Macrocephalae 30g, Rhizoma Atractylodis 30g; Described ministerial drug comprises Semen Coicis 30g, Cortex Phellodendri 20g, Radix Cyathulae 30g, Fructus Amomi Rotundus 30g; Described adjuvant drug comprises Pseudobulbus Cremastrae Seu Pleiones 9g, Rhizoma Smilacis Glabrae 30g, Rhizoma Dioscoreae Septemlobae 15g;

As patient's heat lays particular stress on, then in Chinese medicine preparation, add Herba Taraxaci 12g, Herba Plantaginis 135g;

Lay particular stress on as patient is wet, then in Chinese medicine preparation, add Caulis Sinomenii 13g;

As patient's windage yaw weight, then in Chinese medicine preparation, add Radix Cynanchi Paniculati 13g;

In the gout catabasis, Therapeutic Principle should with invigorating the spleen and replenishing QI, holds concurrently with removing damp and turbid, can treating both the principal and secondary aspects of a disease; Side's medicine can get on the product of the heat-clearing and toxic substances removing such as Radix Cynanchi Paniculati, Herba Taraxaci, Pseudobulbus Cremastrae Seu Pleiones, Caulis Sinomenii on basis up, adds with Radix Astragali 20g, Radix Codonopsis 12g, Pericarpium Citri Reticulatae 13g invigorating the spleen and replenishing QI for substantially square;

As abdominal distention diarrhoea, loose stool person adds Poria 12g, Rhizoma Dioscoreae 20g, Fructus Amomi 13g;

As soreness of the waist and knees, clear urine in large amounts person adds Cortex Cinnamomi 7g, Rhizoma Cibotii 10g;

As belch acid regurgitation, the vexed person of gastral cavity abdominal distention adds Radix Bupleuri 11g, Radix Curcumae 10g;

As limb edema, purplish tongue adds Radix Angelicae Sinensis 10g, Rhizoma Chuanxiong 10g, Radix Salviae Miltiorrhizae 11g;

As under convenience, abnormal smells from the patient is smelly dirty, and anus has burning sensation, and person adds Radix Scutellariae 8g, Rhizoma Coptidis 8g, Herba Hedyotidis Diffusae 20g;

As with the passing of time pain do not go person to add Scolopendra 1.5g, Pheretima 8g, Caulis Spatholobi 20g.

Embodiment 2

Treat a Chinese medicine preparation for gout, this Chinese medicine preparation comprises monarch drug, ministerial drug and adjuvant drug, and in quality g, described monarch drug comprises: Rhizoma Atractylodis Macrocephalae 10g, Rhizoma Atractylodis 10g; Described ministerial drug comprises Semen Coicis 10g, Cortex Phellodendri 10g, Radix Cyathulae 10g, Fructus Amomi Rotundus 10g; Described adjuvant drug comprises Pseudobulbus Cremastrae Seu Pleiones 3g, Rhizoma Smilacis Glabrae 10g, Rhizoma Dioscoreae Septemlobae 10g;

As patient's heat lays particular stress on, then in Chinese medicine preparation, add Herba Taraxaci 15g, Herba Plantaginis 15g;

Lay particular stress on as patient is wet, then in Chinese medicine preparation, add Caulis Sinomenii 15g;

As patient's windage yaw weight, then in Chinese medicine preparation, add Radix Cynanchi Paniculati 15g;

In the gout catabasis, Therapeutic Principle should with invigorating the spleen and replenishing QI, holds concurrently with removing damp and turbid, can treating both the principal and secondary aspects of a disease; Side's medicine can get on the product of the heat-clearing and toxic substances removing such as Radix Cynanchi Paniculati, Herba Taraxaci, Pseudobulbus Cremastrae Seu Pleiones, Caulis Sinomenii on basis up, adds with Radix Astragali 30g, Radix Codonopsis 15g, Pericarpium Citri Reticulatae 15g invigorating the spleen and replenishing QI for substantially square;

As abdominal distention diarrhoea, loose stool person adds Poria 15g, Rhizoma Dioscoreae 30g, Fructus Amomi 15g;

As soreness of the waist and knees, clear urine in large amounts person adds Cortex Cinnamomi 10g, Rhizoma Cibotii 15g;

As belch acid regurgitation, the vexed person of gastral cavity abdominal distention adds Radix Bupleuri 15g, Radix Curcumae 15g;

As limb edema, purplish tongue adds Radix Angelicae Sinensis 15g, Rhizoma Chuanxiong 15g, Radix Salviae Miltiorrhizae 15g;

As under convenience, abnormal smells from the patient is smelly dirty, and anus has burning sensation, and person adds Radix Scutellariae 10g, Rhizoma Coptidis 10g, Herba Hedyotidis Diffusae 30g;

As with the passing of time pain do not go person to add Scolopendra 2g, Pheretima 10g, Caulis Spatholobi 30g.

Embodiment 3

Treat a Chinese medicine preparation for gout, this Chinese medicine preparation comprises monarch drug, ministerial drug and adjuvant drug, and in quality g, described monarch drug comprises: Rhizoma Atractylodis Macrocephalae 20g, Rhizoma Atractylodis 20g; Described ministerial drug comprises Semen Coicis 20g, Cortex Phellodendri 15g, Radix Cyathulae 20g, Fructus Amomi Rotundus 20g; Described adjuvant drug comprises Pseudobulbus Cremastrae Seu Pleiones 6g, Rhizoma Smilacis Glabrae 20g, Rhizoma Dioscoreae Septemlobae 12g;

As patient's heat lays particular stress on, then in Chinese medicine preparation, add Herba Taraxaci 10g, Herba Lysimachiae 10-15g;

Lay particular stress on as patient is wet, then in Chinese medicine preparation, add Rhizoma Paridis 10-15g;

As patient's windage yaw weight, then in Chinese medicine preparation, add Radix Cynanchi Paniculati 10-15g;

In the gout catabasis, Therapeutic Principle should with invigorating the spleen and replenishing QI, holds concurrently with removing damp and turbid, can treating both the principal and secondary aspects of a disease; Side's medicine can get on the product of the heat-clearing and toxic substances removing such as Radix Cynanchi Paniculati, Rhizoma Paridis, Herba Taraxaci, Pseudobulbus Cremastrae Seu Pleiones on basis up, adds with Radix Astragali 10-30g, Radix Codonopsis 10g, Pericarpium Citri Reticulatae 10g invigorating the spleen and replenishing QI for substantially square;

As abdominal distention diarrhoea, loose stool person, then add Poria 10g, Rhizoma Dioscoreae 10g, Fructus Amomi 10g;

As soreness of the waist and knees, clear urine in large amounts person, then add Cortex Cinnamomi 3g, Rhizoma Cibotii 6g;

As belch acid regurgitation, the vexed person of gastral cavity abdominal distention, then add Radix Bupleuri 6g, Radix Curcumae 6g;

As limb edema, purplish tongue person, then add Radix Angelicae Sinensis 6g, Rhizoma Chuanxiong 6g, Radix Salviae Miltiorrhizae 6g;

As under convenience, abnormal smells from the patient is smelly dirty, anus has burning sensation person, then adds Radix Scutellariae 6g, Rhizoma Coptidis 6g, Herba Hedyotidis Diffusae 10g;

As with the passing of time pain do not go person, then add Scolopendra 1g, Pheretima 6g, Caulis Spatholobi 10g.

One, in Chinese medicine preparation of the present invention, the function of each component and function cure mainly

"Nei Jing" has cloud: " all damp-edema are full, all belong to spleen ".The spleen has the function to transport and transform nutrients, the precise and tiny and the lucid yang sending up of clothization, stomach receiving food and drink, digesting food and main the turbid descending, and The spleen and stomach provide the material basis of the acquired, source of generating QI and blood, and spleen rises and is then good for, stomach fall then and, spleen soil is strong, and to transport then essence of water and grainization raw be QI and blood, and defeated cloth moistens foster internal organs organ.Patient is as insufficiency of the spleen in ferritic, and eating and drinking without temperance, easily causes dysfunction of spleen and stomach in addition, the clear failing to ascend and the turbid failing to descend, the water transporting that wets is obstructed, and damp is stagnated in body, stay note extremities joint, strongly fragrant and heat-transformation, damp-heat arthralgia resistance passages through which vital energy circulates, redness and swelling of joints burning pain, dysfunction, spleen governing limbs, becomes under moist, therefore gout is mainly in distal limbs joint, is especially apt to occur in Metatarsophalangeal joint.

It is main for should focusing on invigorating the spleen and stomach in the catabasis, and clearing away heat and eliminating dampness is, emphasizes the principle of differentiation of tcm, treatment must aim at the pathogenesis of disease, identification of etiology according to differenciation of symptoms and signs, dialectical treatmert, plus-minus medication, how can make the strong fortune of taste and damp and hot from removing.The suitable symptomatic treatment in acute condition of acute treatment, giving consideration to both the incidental and fundamental is advisable.Gout acute attack is with redness and swelling of joints, and night increases the weight of, and the play of movable pain is main, can with fever with aversion to cold, head-body-pain, dry mouth and constipation, red tongue greasy fur, the symptom such as full and large pulse or stringy and rapid pulse.Lab testing prompting blood uric acid obviously raises.The multifactor body of this phase patient is insufficiency of the spleen, retention of damp-heat in the interior, multiple sense gas frequently, or feelings will is not smooth, or eating and drinking without temperance, and onset is hurried.

Rhizoma Atractylodis Macrocephalae bitter but sweet flavor, slightly warm in nature, Rhizoma Atractylodis are arduous and warm, and the two all enters taste two warp, is monarch drug altogether, both can air making-up and spleen enlivening, again can dampness diuretic ministerial drug.Semen Coicis is cool in nature, slightly sweet flavor, has spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, effect of heat clearing away toxin expelling; Cortex Phellodendri property of medicine bitter cold, kind clear damp-heat in lower-JIAO, has heat clearing and damp drying, the merit of eliminating fire and detoxication; Radix Cyathulae can invigorating the liver and kidney, bone and muscle strengthening, blood circulation promoting and blood stasis dispelling, inducing diuresis for treating stranguria syndrome, and priming is descending; Fructus Amomi Rotundus acrid in the mouth, warm in nature, can removing dampness circulation of qi promoting, warming spleen and stomach for dispelling cold.Above four medicines are ministerial drug altogether, and auxiliary two art invigorating the spleen for eliminating dampness, make damp go from the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels.Pseudobulbus cremastrae seu pleiones clearing heat, detoxicating, dispelling dampness; Rhizoma Smilacis Glabrae slightly sweet flavor is put down, and can put down by expelling wind and dampness ， Rhizoma Dioscoreae Septemlobae bitter in the mouth, master secretes not turbid clearly, oozes dampness removing heat, expelling wind and removing dampness.Herba Taraxaci, Herba Lysimachiae, Herba Plantaginis water is treating stranguria, heat-clearing and toxic substances removing, effect of dissipating blood stasis for subsidence of swelling, Rhizoma Paridis, Caulis Sinomenii clearing heat, detoxicating, dispelling dampness, Radix Cynanchi Paniculati wind-expelling pain-stopping, promoting blood circulation and detoxication.

Research proves that the Rhizoma Atractylodis Macrocephalae can extend lymphocyte life span, the ability of enhancing body scavenging free radicals, has obvious antioxidation; The compositions such as the atisine chloride atractydin contained by Rhzoma Atractylodis Lanceae volatile oil, hinesol and eudesmol, have and improve insufficiency of the spleen, to promote liver protein synthesis, the antiinflammatory effect.Two arts all have lasting diuresis simultaneously, and not only increasing urine volume, can also increase the excretion of sodium ion, is electrolytical reuptake inhibithors.Cortex Phellodendri can suppress mouse liver xanthine oxidase activity significantly, reduces Mouse Blood uric acid level.Radix Achyranthis Bidentatae can activate the phagocytic activity of giant cell to antibacterial, has blood vessel dilating, improves circulation, promotes that inflammatory lesion absorbs, improve immunity of organisms.Semen Coicis has gentle antalgic and inflammation relieving, can strengthen body immunity.Herba Lysimachiae calculus is treating stranguria, can promote that purine excretes, and suppresses tophus to be formed.Herba Plantaginis ethanol extraction can suppress purinase, makes hypoxanthine and xanthine not transform uric acid, thus reduces serum Uric Acid Concentration, suppresses tophus to be formed, impels tophus to degrade.Rhizoma Smilacis Glabrae, Rhizoma Dioscoreae Septemlobae becomes can reduce serum uric acid level in body.In a word, above all medicines, by improving body immunity, diuresis antiinflammatory, increase the approach such as urate excretion, improve human internal environment and reach the object for the treatment of gout.

A kind of Chinese medicine preparation for the treatment of gout of the present invention can be granule, decoction, capsule or unguentum, to calculate and in clinical case at following acute toxicity testing, toxic dose, described gout granule, the gout soup that disappears clearly that disappears clearly is a kind of Chinese medicine preparation for the treatment of gout of the present invention.

Two, acute toxicity testing

Get healthy mice 24; male and female half and half; after fasting 24h; crude drug in next day gavage give gout granules particle suspension 0.78ml (16.30g/kg; suitable crude drug amount 86.88g/kg); observe the situations such as mice activity, diet, breathing, then Continuous Observation 15 days, notes down the animal dead number in 7 days and toxic reaction.Result: after gavage, mice activity reduces, and about 1 hours is alleviated gradually, 24 none only dead and obviously toxic reactions of mice in 7 days.

three,toxic dose calculates

The gout of joining under the room temperature granule maximum concentration that disappears clearly is 0.417g/ml (16.30g/kg, suitable crude drug amount 86.88g/kg), grain density 4.73g/ml.20g Mouse Stomach internal volume 0.78ml.Converting by animal surface area ratio rate conversion dose,equivalent, (20g mice: 70Kg is grown up=381.9 :1) by maximum concentration 4.73g/ml(suitable crude drug dosage 22.23g/ml) and mice maximum gavage capacity 0.78ml calculate: the maximum dosage of mice: 4.73*0.78/0.02=207.87g/kg; Convert by animal surface area ratio rate conversion dose,equivalent, conversion 70Kg adult maximum dosage-feeding: 207.87*0.02*387.9=1612.66g/70kg, suitable crude drug dosage 7579.5g/70Kg.Adult's every day, oral gout disappeared clearly granule crude drug dosage 30g/70kg, mice once oral gout disappear clearly granule be adult's every day clinical usual amounts 253 times: 7579.5/30=253 times of mice once disappear the clearly maximum tolerated dose of granule of oral gout be 86.88g/kg, this is 253 times of clinical usual amounts every day of being grown up, and result shows the clinical usual amounts use safety of this medicine oral administration.

Four, clinical case

Typical cases one:

Zhang, man, 46 years old, first visit on May 5 in 2012.Patient to be everlasting outer dinner party of drinking because of job demand, last night and friend stoke of midnight outside, edible lot of beer and after roasting, and occurs Zuo Hallux toe, Metatarsophalangeal joint has an intense pain about when morning 4, hypnalgia is waken up, and is difficult to stand, and after slightly movable, pain increases the weight of, not tangible, can not walk, dry mouth with bitter taste, indigestion and loss of appetite, abdominal distention, vexed, to sleep difference, oliguria with reddish urine, loose stool, red tongue, yellow, greasy and thin fur, soft and rapid pulse.Health check-up: T:37.6 DEG C, R21 beat/min, HR:92 time/min, BP125/74mmHg.Lab testing: blood uric acid: 802 μm of ol/L, erythrocyte sedimentation rate 62mm/h.Western medicine diagnose is gouty arthritis acute attack, Chinese medical discrimination: arthromyodynia, card belongs to dysfunction of the spleen in transportation, damp-heat arthralgia hinders, control with air making-up and spleen enlivening, clearing away heat-damp and promoting diuresis, side subtracts with gout Qing Xiao Tonga: Rhizoma Atractylodis Macrocephalae 15g, Rhizoma Atractylodis 30g, Semen Coicis 15g, Cortex Phellodendri 15g, Radix Achyranthis Bidentatae 10g, Fructus Amomi Rotundus 15g, Herba Lysimachiae 15g, Herba Plantaginis 30g, Radix Cynanchi Paniculati 15g, Herba Asari 3g, Rhizoma Smilacis Glabrae 30g, Rhizoma Paridis 15g, Rhizoma Dioscoreae Septemlobae 15g, Herba Taraxaci 15g.Every day 1 dose, be decocted in water for oral dose, take at twice.Advise patient fasts seafood, rich, the contour purine food of medicated beer, light diet.

20 days two May in 2012 examines, and patient tells redness and swelling of joints burning pain when taking the 3rd dose, top obviously disappears, and tenderness alleviates, and toes movable function is normal, can walk, and movable normal, abdominal distention, indigestion and loss of appetite, loose stool, body of the tongue is light red, yellow and thin fur, soft pulse.Check blood uric acid: 484 μm of ol/L, erythrocyte sedimentation rate 38mm/h, following the service gout Qing Xiao Tonga subtracts: Rhizoma Atractylodis Macrocephalae 30g, Rhizoma Atractylodis 15g, Semen Coicis 15g, Cortex Phellodendri 10g, Radix Achyranthis Bidentatae 10g, Fructus Amomi Rotundus 20g, Herba Lysimachiae 15g, Herba Plantaginis 15g, Radix Cynanchi Paniculati 15g, Rhizoma Smilacis Glabrae 30g, Rhizoma Paridis 15g, Rhizoma Dioscoreae Septemlobae 15g, Herba Taraxaci 15g.Every day 1 dose, be decocted in water for oral dose, take at twice.Check after first quarter moon, patient's toes red and swollen heat pain disappears, and joint motion is as usual, blood uric acid: 375 μm of ol/L, erythrocyte sedimentation rate 12mm/h.Advise and note life conditioning, follow up a case by regular visits to after half a year and have no recurrence.

Press: Huan person Zuo Hallux toe, Metatarsophalangeal joint have an intense pain, local skin red and swollen heat pain, blood uric acid raise situation, Western medicine diagnose its be acute gouty arthritis, tcm diagnosis is arthromyodynia.Excessive drinking and all hinder spleen transporting must cause dysfunction of the spleen in transportation, the clear failing to ascend and the turbid failing to descend addicted to food greasy and surfeit flavour, water wets transporting obstacle, strongly fragrant and heat-transformation, in conjunction with tongue arteries and veins, all belongs to dysfunction of the spleen in transportation, damp-heat arthralgia resistance passages through which vital energy circulates, therefore works as the spleen strengthening and damp drying.Rhizoma Atractylodis Macrocephalae bitter but sweet flavor in side, slightly warm in nature, Rhizoma Atractylodis are arduous and warm, and the two all enters taste two warp, is monarch drug altogether, both can air making-up and spleen enlivening, again can dampness diuretic.Semen Coicis is cool in nature, slightly sweet flavor, has spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, effect of heat clearing away toxin expelling.Cortex Phellodendri property of medicine bitter cold, kind clear damp-heat in lower-JIAO, has heat clearing and damp drying, the merit of eliminating fire and detoxication.Radix Achyranthis Bidentatae can invigorating the liver and kidney, bone and muscle strengthening, blood circulation promoting and blood stasis dispelling, inducing diuresis for treating stranguria syndrome, and priming is descending, Fructus Amomi Rotundus acrid in the mouth, warm in nature, can removing dampness circulation of qi promoting, warming spleen and stomach for dispelling cold.Above four medicines are ministerial drug altogether, and auxiliary two art invigorating the spleen for eliminating dampness, make damp go from the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels.Herba Lysimachiae strengthens the merit of relieving stranguria by diuresis, heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling, and Herba Plantaginis has heat-clearing and toxic substances removing, effect of diuresis; Rhizoma Smilacis Glabrae, slightly sweet flavor is put down, and returns through liver stomach, energy expelling wind and dampness; Rhizoma Dioscoreae Septemlobae bitter in the mouth is put down, and returns liver stomach warp, and master secretes not turbid clearly, oozes dampness removing heat, expelling wind and removing dampness; The pain relieving of Radix Cynanchi Paniculati Eradicates wind, promoting blood circulation and detoxication; Rhizoma Paridis, Herba Taraxaci heat-clearing and toxic substances removing, reducing swelling and alleviating pain, inducing diuresis for treating stranguria syndrome.The all medicines of full side share plays air making-up and spleen enlivening, clearing away heat-damp and promoting diuresis, the merit of removing obstruction in the collateral to relieve pain altogether.

Patient's redness and swelling of joints burning pain symptom when first visit is obvious, works as symptomatic treatment in acute condition, therefore reuse Cortex Phellodendri, Rhizoma Atractylodis, Herba Plantaginis on gout disappears clearly soup basis, adds the merit with strengthening Herba Asari removing obstruction in the collateral to relieve pain.Two patients when examining swell and ache and comparatively before disappear, but the insufficiency of the spleen symptom such as abdominal distention, indigestion and loss of appetite, loose stool still exists, therefore former side basis are reduced Cortex Phellodendri, Rhizoma Atractylodis and Herba Plantaginis dosage, reuse the Rhizoma Atractylodis Macrocephalae, Fructus Amomi Rotundus with spleen invigorating circulation of qi promoting, fragrant dampness.

Typical cases two:

Liu so-and-so, man, 51 years old, first visit on July 15 in 2013.Patient is addicted to drink and preference for fat and sweet food savoury, gout medical history 14 years, usually oral allopurinol treatment.Occur left Hallux toe, Metatarsophalangeal joint red swelling of the skin burning pain before 3 days after drinking morning, left ankle joint is stiff can not walk, and bilateral ear edge is laid one's hand on and tuberosity, and head body generates heat, dry mouth with bitter taste, indigestion and loss of appetite, distension and fullness in the abdomen, vexed, difference of sleeping, oliguria with reddish urine, defecate smelly dirty, red tongue, yellow and greasy fur, slippery and rapid pulse.Health check-up: T:38.0 DEG C, R23 beat/min, HR:92 time/min, BP138/76mmHg, lab testing: blood uric acid: 724 μm of ol/L, erythrocyte sedimentation rate 73mm/h.Western medicine diagnose is acute gouty arthritis, Chinese medical discrimination: arthromyodynia, card belongs to dysfunction of the spleen in transportation, damp-heat arthralgia hinders, control with invigorating the spleen and benefiting QI, clearing away heat and eliminating dampness, side subtracts with gout Qing Xiao Tonga: each 15g of pale art, Semen Coicis 30g, Cortex Phellodendri 15g, Radix Cyathulae 10g, Fructus Amomi Rotundus 15g, Herba Lysimachiae 15g, Pseudobulbus Cremastrae Seu Pleiones 6g, Herba Plantaginis 15g, Radix Cynanchi Paniculati 15g, Herba Asari 3g, Rhizoma Smilacis Glabrae 15g, Rhizoma Paridis 10g, Rhizoma Dioscoreae Septemlobae 15g, Herba Taraxaci 10g, Caulis Sinomenii 15g.Every day 1 dose, be decocted in water for oral dose, take at twice, totally 10 doses.Advise patient fasts seafood, rich, the contour purine food of medicated beer, take a good rest.

25 days two July in 2013 examines, and patient tells redness and swelling of joints burning pain when taking the 3rd dose, top disappears, and tenderness alleviates, and toes movable function is normal, and fever of the body removes, still feels gastral cavity abdominal distention vexed, indigestion and loss of appetite, loose stool, and body of the tongue is light red, yellow and thin fur, soft pulse.Check blood uric acid: 464 μm of ol/L, erythrocyte sedimentation rate 46mm/h, following the service gout Qing Xiao Tonga subtracts: Rhizoma Atractylodis Macrocephalae 15g, Rhizoma Atractylodis 15g, Semen Coicis 30g, Cortex Phellodendri 10g, Radix Cyathulae 10g, Radix Astragali 15g, Radix Codonopsis 15g, Pericarpium Citri Reticulatae 15g, Fructus Amomi Rotundus 15g, Herba Lysimachiae 15g, Herba Plantaginis 15g, Rhizoma Smilacis Glabrae 15g, Rhizoma Dioscoreae Septemlobae 15g, Rhizoma Dioscoreae 20g, Fructus Amomi 15g.Every day 1 dose, be decocted in water for oral dose, take at twice, totally 10 doses.

5 days three August in 2013 examines, and the left Hallux toe of trouble person, Metatarsophalangeal joint red and swollen heat pain disappear, and left ankle moving is as usual, but still has a dull ache, check blood uric acid: 325 μm of ol/L, erythrocyte sedimentation rate 16mm/h.Advise it to sob the product such as Semen Coicis medicated porridge or yam porridge at ordinary times more, notice that life is adjusted, follow up a case by regular visits to after half a year and have no recurrence.

Note: for a long time all hindering transporting and transforming function of the spleen and stomach addicted to food greasy and surfeit flavour and wine sweet wine must cause, dysfunction of the spleen in transportation, stomach-QI being unable to descend normally, water wets transporting obstacle, with the passing of time heat-transformation, damp invasion of lower energizer, therefore visible head body heating, the full vexed discomfort of abdominal part, dry mouth with bitter taste, indigestion and loss of appetite; oliguria with reddish urine, defecate smelly dirty, red tongue, yellow and greasy fur, slippery and rapid pulse; Damp pathogen being sticky and stagnant in nature and under becoming, stay note extremities joint, therefore visible joint has an intense pain, red swelling of the skin burning pain.This phase method works as invigorating the spleen and benefiting QI, clearing away heat and eliminating dampness, and Deng Yun penetrating judgment is authorized gout and to be disappeared clearly side based on soup, reuses Cortex Phellodendri, Rhizoma Atractylodis, Herba Plantaginis, adds and use Herba Asari removing obstruction in the collateral to relieve pain.Two conditions of patients when examining are alleviated, but the insufficiency of the spleen symptoms such as gastral cavity abdominal distention is vexed, indigestion and loss of appetite, loose stool still exist, this phase should based on invigorating the spleen and replenishing QI, hold concurrently with removing damp and turbid, therefore Deng Yun penetrating judgment awards the product of the heat-clearing and toxic substances removing such as Radix Cynanchi Paniculati, Rhizoma Paridis, Herba Taraxaci, Pseudobulbus Cremastrae Seu Pleiones, Caulis Sinomenii that to get on former side basis, Cortex Phellodendri, Rhizoma Atractylodis and Herba Plantaginis decrement, reuse the Rhizoma Atractylodis Macrocephalae, Fructus Amomi Rotundus with spleen invigorating circulation of qi promoting, fragrance dampness, and add with the Radix Astragali, Radix Codonopsis, Pericarpium Citri Reticulatae, Poria, Rhizoma Dioscoreae air making-up and spleen enlivening dampness removing.Three blood uric acids of patient when examining, erythrocyte sedimentation rate reach normal range, but patient's gout medical history reaches 14 years, and left foot still has and has a dull ache, and the state of an illness enters the intermission.Deng Yun penetrating judgment is awarded and is thought that this phase still must solid protection healthy energy, continues function of spleen and stomach regulating, emphasizes preventive treatment of disease, should instruct the product of patient's polyphagia Semen Coicis or Rhizoma Dioscoreae and so on spleen invigorating usually, notes life conditioning, the recurrence of prevention gout.

Although done comparatively detailed elaboration to technical scheme of the present invention and enumerated; be to be understood that; to those skilled in the art; amendment is made to above-described embodiment or adopts equivalent replacement scheme; this is apparent to those skilled in the art; these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.

Claims

1. treat a Chinese medicine preparation for gout, it is characterized in that, this Chinese medicine preparation comprises monarch drug, ministerial drug and adjuvant drug, and in mass parts, described monarch drug comprises: Rhizoma Atractylodis Macrocephalae 10-30 part, Rhizoma Atractylodis 10-30 part; Described ministerial drug comprises Semen Coicis 10-30 part, Cortex Phellodendri 10-20 part, Radix Cyathulae 10-30 part, Fructus Amomi Rotundus 10-30 part; Described adjuvant drug comprises Pseudobulbus Cremastrae Seu Pleiones 3-9 part, Rhizoma Smilacis Glabrae 10-30 part, Rhizoma Dioscoreae Septemlobae 10-15 part.

2. a kind of Chinese medicine preparation for the treatment of gout according to claim 1, is characterized in that, in mass parts, described adjuvant drug also comprises Herba Taraxaci 10-15 part, Herba Lysimachiae 10-15 part or Herba Plantaginis 10-30 part.

3. a kind of Chinese medicine preparation for the treatment of gout according to claim 1, is characterized in that, in mass parts, described adjuvant drug also comprises Rhizoma Paridis 10-15 part or Caulis Sinomenii 10-15 part.

4. a kind of Chinese medicine preparation for the treatment of gout according to claim 1, is characterized in that, in mass parts, described adjuvant drug also comprises Radix Cynanchi Paniculati 10-15 part.

5. a kind of Chinese medicine preparation for the treatment of gout according to claim 1, is characterized in that, in mass parts, described adjuvant drug also comprises Radix Astragali 10-30 part, Radix Codonopsis 10-15 part, Pericarpium Citri Reticulatae 10-15 part, Poria 10-15 part, Rhizoma Dioscoreae 10-30 part, Fructus Amomi 10-15 part.

6. a kind of Chinese medicine preparation for the treatment of gout according to claim 1, is characterized in that, in mass parts, described adjuvant drug also comprises Radix Astragali 10-30 part, Radix Codonopsis 10-15 part, Pericarpium Citri Reticulatae 10-15 part, Cortex Cinnamomi 3-10 part, Rhizoma Cibotii 6-15 part.

7. a kind of Chinese medicine preparation for the treatment of gout according to claim 1, is characterized in that, in mass parts, described adjuvant drug also comprises Radix Astragali 10-30 part, Radix Codonopsis 10-15 part, Pericarpium Citri Reticulatae 10-15 part, Radix Bupleuri 6-15 part, Radix Curcumae 6-15 part.

8. a kind of Chinese medicine preparation for the treatment of gout according to claim 1, is characterized in that, in mass parts, described adjuvant drug also comprises Radix Astragali 10-30 part, Radix Codonopsis 10-15 part, Pericarpium Citri Reticulatae 10-15 part, Radix Angelicae Sinensis 6-15 part, Rhizoma Chuanxiong 6-15 part, Radix Salviae Miltiorrhizae 6-15 part.

9. a kind of Chinese medicine preparation for the treatment of gout according to claim 1, it is characterized in that, in mass parts, described adjuvant drug also comprises Radix Astragali 10-30 part, Radix Codonopsis 10-15 part, Pericarpium Citri Reticulatae 10-15 part, Radix Scutellariae 6-10 part, Rhizoma Coptidis 6-10 part, Herba Hedyotidis Diffusae 10-30 part.

10. a kind of Chinese medicine preparation for the treatment of gout according to claim 1, is characterized in that, in mass parts, described adjuvant drug also comprises Radix Astragali 10-30 part, Radix Codonopsis 10-15 part, Pericarpium Citri Reticulatae 10-15 part, Scolopendra 1-2 part, Pheretima 6-10 part, Caulis Spatholobi 10-30 part.