CN104524342B - 一种四降保元中药制剂及其膏剂的制备方法 - Google Patents
一种四降保元中药制剂及其膏剂的制备方法 Download PDFInfo
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Abstract
本发明公开了一种四降保元中药制剂,包括薏苡仁、决明子、荷叶、车前草、绞股蓝、葛根、白术、玉米须、土茯苓、杭白菊、西洋参诸位中药,一种四降保元膏剂的制备方法,包括以下步骤:第一步,将参诸位中药加水煎煮两次,将两次煎煮得到的煎液分别过滤,将滤液合并并且浓缩;第二步,向浓缩液中加入木糖醇,调至挂旗状,即为四降保元膏剂的成品。本发明的一种四降保元中药制剂的薏苡仁有健脾渗湿,除痹止泻之功效,决明子可清肝明目、润肠通便,从而达到降尿酸、降血糖、降血脂及降血压作用;本发明的一种四降保元膏剂的制备方法通过两次煎煮,能够有效的提取药物的有效成分,制成的膏剂方便使用。
Description
技术领域
本发明涉及一种中药制剂及其膏剂的制备方法,尤其涉及一种四降保元中药制剂及其膏剂的制备方法。
背景技术
随着生活条件的改善和饮食结构的变化,高血压、高血糖、高血脂、高尿酸血症已成为老百姓的多发病、常见病,并呈逐年上升趋势,已成为社会公认的顽症,往往终身不愈。高尿酸血症患者高血压的发生率为57.97%,高血糖的发生率为15.94%,卨尿酸血症与肥胖、高血脂的发生率均存在相关性。因此高尿酸血症、高血压、高血糖及高血脂症并称为“四高”。其病因、病机多有关联,错综复杂,医界虽多有关注和研究,目前尚无有效治疗方法。西医对四高通常分别进行治疗,患者常常需要终身服药,且均为化学药物,治疗的目的是以抑制或维持病情为主,其副作用常常令人生畏。
发明内容
为了克服现有技术中西医对四高治疗效果不佳,其副作用大的缺陷,提供一种四降保元中药制剂及其膏剂的制备方法。
本发明通过下述方案实现:
一种四降保元中药制剂,包括君药、臣药和佐药,以质量份计,所述君药包括薏苡仁10-30份、决明子15-30份;
所述臣药包括荷叶10-30份、车前草10-30份、绞股蓝15-30份、葛根15-30份、白术10-15份;
所述佐药包括土茯苓15-30份、玉米须15-30份、杭白菊15-30份、西洋参10-15份;
以质量份计,该中药制剂还包括木糖醇30-100份。
所述君药包括薏苡仁15份、决明子20份;
所述臣药包括荷叶10份、车前草15份、绞股蓝20份、葛根15份、白术15份;
所述佐药包括土茯苓20份、玉米须20份、杭白菊15份、西洋参10份。
该中药制剂为颗粒剂、汤剂、胶囊或者膏剂。
一种四降保元膏剂的制备方法,包括以下步骤:
第一步,将薏苡仁、决明子、荷叶、车前草、绞股蓝、葛根、白术、玉米须、土茯苓、杭白菊、西洋参诸味中药煎煮,将煎煮得到的煎液过滤,将滤液浓缩至密度为1.1-1.3 g/mL的浓缩液;
第二步,向浓缩液中加入少量木糖醇,调至挂旗状,即为四降保元膏剂的成品。
在第一步中,所述诸味中药经过两次加水煎煮,两次煎煮的第一次煎煮为100-110分钟,第二次煎煮为60-90分钟,两次煎煮后分别将滤液过滤后合并浓缩至密度为1.1g/mL的浓缩液。
以质量份计,所述诸味中药的用量如下:薏苡仁10-30份、决明子15-30份、荷叶10-30份、车前草10-30份、绞股蓝15-30份、葛根15-30份、白术10-15份、土茯苓15-30份、玉米须15-30份、杭白菊15-30份、西洋参10-15份。
以质量份计,所述木糖醇的用量为30-100份。
本发明的有益效果为:
1.本发明的一种四降保元中药制剂采用薏苡仁、决明子为君药,薏苡仁有健脾渗湿,除痹止泻之功效,决明子可清肝明目、润肠通便,再以荷叶、车前草等为臣药,清热解暑、升发清阳、健脾利湿,从而达到降尿酸、降血糖、降血脂及降血压作用;
2.本发明的一种四降保元膏剂的制备方法通过两次煎煮,能够有效的提取药物的有效成分,制成的膏剂方便使用。
具体实施方式
下面结合具体实施例对本发明进一步说明:
实施例1
一种四降保元中药制剂,包括君药、臣药和佐药,以质量份计,所述君药包括薏苡仁10份、决明子15份;
所述臣药包括荷叶30份、车前草30份、绞股蓝30份、葛根30份、白术15份;
所述佐药包括土茯苓15份、玉米须15份、杭白菊15份、西洋参10份;以质量份计,该中药制剂还包括木糖醇30份。
其为颗粒剂、汤剂、胶囊或者膏剂。
一种四降保元膏剂的制备方法,包括以下步骤:
第一步,将薏苡仁、决明子、荷叶、车前草、绞股蓝、葛根、白术、玉米须、土茯苓、杭白菊、西洋参诸味中药加水煎煮两次,将两次煎煮得到的煎液分别过滤,将滤液合并并且浓缩至密度为1.2g/mL的浓缩液;其中,两次煎煮的第一次煎煮为105分钟,第二次煎煮为75分钟;
第二步,向浓缩液中加入木糖醇70份,调至挂旗状,即为四降保元膏剂的成品。
本发明添加不具有增加血糖作用的木糖醇,提高本发明四降保元中药制剂对糖尿病人的适用性。
实施例2
一种四降保元中药制剂,包括君药、臣药和佐药,以质量份计,所述君药包括薏苡仁30份、决明子30份;
所述臣药包括荷叶10份、车前草10份、绞股蓝15份、葛根15份、白术10份;
所述佐药包括土茯苓30份、玉米须30份、杭白菊30份、西洋参15份,以质量份计,该中药制剂还包括木糖醇60份。
其为颗粒剂、汤剂、胶囊或者膏剂。
一种四降保元膏剂的制备方法,包括以下步骤:
第一步,将薏苡仁、决明子、荷叶、车前草、绞股蓝、葛根、白术、玉米须、土茯苓、杭白菊、西洋参诸味中药加水煎煮两次,将两次煎煮得到的煎液分别过滤,将滤液合并并且浓缩至密度为1.1g/mL的浓缩液;其中,两次煎煮的第一次煎煮为110分钟,第二次煎煮为90分钟;
第二步,向浓缩液中加入木糖醇100份,调至挂旗状,即为四降保元膏剂的成品。
实施例3
一种四降保元中药制剂,包括君药、臣药和佐药,以质量份计,所述君药包括薏苡仁20份、决明子22份;
所述臣药包括荷叶20份、车前草20份、绞股蓝22份、葛根22份、白术13份;
所述佐药包括土茯苓23份、玉米须21份、杭白菊24份、西洋参12份,以质量份计,该中药制剂还包括木糖醇100份。
其为颗粒剂、汤剂、胶囊或者膏剂。
一种四降保元膏剂的制备方法,包括以下步骤:
第一步,按上述比例称取薏苡仁、决明子、荷叶、车前草、绞股蓝、葛根、白术、玉米须、土茯苓、杭白菊、西洋参诸味中药,然后加水煎煮两次,将两次煎煮得到的煎液分别过滤,将滤液合并并且浓缩至密度为1.3g/mL的浓缩液;其中,两次煎煮的第一次煎煮为100分钟,第二次煎煮为70分钟;
第二步,向浓缩液中加入木糖醇30份,调至挂旗状,即为四降保元膏剂的成品。
一、本发明中各个组分的功能和功能主治;
中医认为高尿酸血症、高血压、高血糖及高血脂症常常因脾虚水停,痰湿浊毒停滞体内所致。《内经》有云:“诸湿肿满,皆属于脾”。脾主运化,布化精微而主升清;胃主受纳,腐熟水谷而主降浊。脾升则健,胃降则和,脾胃乃后天之本,脾胃健运则输布水谷精微而濡养脏腑。如素体脾虚复有饮食不节,易致脾胃功能失调,升清降浊不畅,水湿运化受阻,湿邪留滞体内,流注四肢关节脾失健运,浊邪内存,痰湿内蕴,《诸病源候论》有“脾胃虚弱,不能克消水浆,故有痰饮也”。《景岳全书》云:“夫人之多痰,皆由中虚使然,果使脾强胃健,如少壮者流,则水谷随食随化,皆成气血,焉得留而为痰,惟其不能尽化,十留一二,则一二为痰,十留三四,则三四为痰矣,甚至留其七八,则但血气日消,而痰涎日多矣”。研究也证实血清胆固醇、甘油三酯、高尿酸、低密度脂蛋白含量的升高是“痰浊”特有的重要生化指标和物质基础。当然,过食肥甘、过量烟酒、运动甚少、优思劳倦均可加重脾肾虚损,导致痰湿内停及肥胖,内外合因,更易致病。
在本发明中,薏苡仁归脾、胃、肺三经,性凉,味甘淡,有健脾渗湿,除痹止泻之功效,清热排毒,主治脾虚泄泻、湿痹筋脉拘挛;决明子归肝、肾、大肠三经,可清肝明目、润肠通便,主治头痛眩晕、肠燥便秘,为君药。
荷叶归心、肝、脾、胆、肺经,清热解暑、升发清阳,治疗头痛眩晕、脾虚腹胀;车前草归肝、肾、膀胱经,清热利尿、凉血、解毒,治疗热结膀胱;小便不利,肝热目赤;咽喉肿痛;绞股蓝归脾、肺经,健脾益气、化痰止咳、清热解毒,脾虚、痰浊阻肺、热毒证;葛根归脾、胃经,生津止渴,热病烦渴、内热消渴、脾虚久泄;白术归脾、胃经,补气健脾、燥湿利水,食少便溏、脘腹胀满、、水肿、小便不利、脾虚气弱。
玉米须归膀胱、肝、胆经,利水消肿、利湿退黄,水肿、小便不利、黄疸;土茯苓归肝、胃经,解毒除湿、通利关节,杭白菊归肺、肝经,发散风热、清肝明目、平抑肝阳、清热解毒,肝阳上亢、头痛眩晕,西洋参归心、肺、胃经,补气养阴、清火生津,治疗气阴两伤之烦倦口渴。
以上诸药合用可降血糖,降尿酸,降血压,降血脂,达到固精保元的作用。
本发明的一种四降保元中药制剂可以为颗粒剂、汤剂、胶囊或者膏剂,下述临床疗效分析、临床病例中的四降保元膏剂都为本发明的一种四降保元中药制剂。
二、临床疗效分析
四降保元膏剂在江西中医药大学附属医院已行临床应用近两年,我院骨伤科门诊与住院部60例患者,生化检查示:血糖、血脂、血尿酸升高,证属:脾肾阳虚,给服四降保元膏剂。
1、总体临床疗效
总有效率为85.32%,显效率为8.13%,总体临床疗效明显;
2、中医证侯疗效
总有效率为94.2%,临床痊愈率17.3%,愈显率74.3%,中医证侯疗效明显,愈显率较高。
三、临床病例
典型病例1
患者李某某,男,58 岁,南昌市进贤县人,2013 年11月患痛风性关节炎,足趾关节红肿热痛,屈伸不便,前来就诊。主诉双足趾反复出现红肿热痛多年,加重1年多,行走不便,素有高血压、糖尿病及高血脂病史,BP164/93mmHg,生化检查示:血尿酸531mmol/L,血糖10.1mmol/L,给服四降保元膏剂50g,每日两次,服完1周后,双足趾红肿热痛大减,复查血尿酸428mmol/L,血糖7.4mmol/L,现再服1月后疼痛基本消除,复查血尿酸、血糖均正常,血压监测均在正常范围,至今已1 年,随访无复发。
典型病例2
患者陈某某,男性,68岁,2012年12月21日,患者曾有高尿酸血症、糖尿病、高血压病史多年,长期口服降糖、降压药物治疗,近期出现胸闷,心悸时存,畏寒,气短,脑鸣,纳可,口干苦,二便调。下肢觉水肿,舌淡红,舌下时瘀曲,苔厚腻,脉弦。BP:160/80mmHg,心脏听诊无异常。中医诊断:心悸(心阳不振,痰瘀阻络)眩晕 消渴 西医诊断:高血压病、冠心病、糖尿病、高尿酸血症,予四降保元膏剂1袋口服,每日1剂,嘱其予西医同时服用,3月后血压、血糖、血脂及血尿酸均在正常范围之内,不适症状消失。
临床疗效分析和临床病例中所用的四降保元膏剂,均为按照本发明的中药制剂配方和膏剂制备方法制备的四降保元膏剂成品。
尽管已经对本发明的技术方案做了较为详细的阐述和列举,应当理解,对于本领域技术人员来说,对上述实施例做出修改或者采用等同的替代方案,这对本领域的技术人员而言是显而易见,在不偏离本发明精神的基础上所做的这些修改或改进,均属于本发明要求保护的范围。
Claims (6)
1.一种四降保元中药制剂,其特征在于:以质量份计,君药为薏苡仁10-30份、决明子15-30份;
臣药为荷叶10-30份、车前草10-30份、绞股蓝15-30份、葛根15-30份、白术10-15份;
佐药为土茯苓15-30份、玉米须15-30份、杭白菊15-30份、西洋参10-15份;
所述四降保元是指降血糖、降尿酸、降血压、降血脂,固精保元。
2.根据权利要求1所述的一种四降保元中药制剂,其特征在于:
所述君药为薏苡仁15份、决明子20份;
所述臣药为荷叶10份、车前草15份、绞股蓝20份、葛根15份、白术15份;
所述佐药为土茯苓20份、玉米须20份、杭白菊15份、西洋参10份。
3.根据权利要求1或2所述的一种四降保元中药制剂,其特征在于:以质量份计,该中药制剂还包括木糖醇30-100份。
4.根据权利要求1或2所述的一种四降保元中药制剂,其特征在于:该中药制剂为颗粒剂、汤剂、胶囊剂或者膏剂。
5.一种如权利要求3所述四降保元中药制剂的制备方法,其特征在于,制备成膏剂,包括以下步骤:
第一步,将薏苡仁、决明子、荷叶、车前草、绞股蓝、葛根、白术、玉米须、土茯苓、杭白菊、西洋参诸味中药煎煮,将煎煮得到的煎液过滤,将滤液浓缩至密度为1.1-1.3g/mL的浓缩液;
第二步,向浓缩液中加入木糖醇,调至挂旗状,即为四降保元膏剂的成品。
6.根据权利要求5所述的一种四降保元膏剂的制备方法,其特征在于:在第一步中,所述诸味中药经过两次加水煎煮,两次煎煮的第一次煎煮为100-110分钟,第二次煎煮为60-90分钟,两次煎煮后分别将滤液过滤后合并浓缩至密度为1.1g/mL的浓缩液。
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Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1423980A (zh) * | 2002-12-28 | 2003-06-18 | 南昌大学 | 决明健康食品及其制备方法 |
CN101129147A (zh) * | 2006-08-23 | 2008-02-27 | 吴伯侯 | 一种薏仁奶 |
CN103100006A (zh) * | 2013-01-30 | 2013-05-15 | 无限极(中国)有限公司 | 一种具有降尿酸功能的中草药组合物 |
CN103190659A (zh) * | 2013-04-12 | 2013-07-10 | 康美药业股份有限公司 | 具有降压降脂和降糖作用的植物饮料及其制备方法和应用 |
CN103250821A (zh) * | 2013-04-17 | 2013-08-21 | 安徽省石台县日新茶叶实业有限公司 | 一种降脂减肥茶及其制备方法 |
-
2015
- 2015-01-16 CN CN201510022410.0A patent/CN104524342B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1423980A (zh) * | 2002-12-28 | 2003-06-18 | 南昌大学 | 决明健康食品及其制备方法 |
CN101129147A (zh) * | 2006-08-23 | 2008-02-27 | 吴伯侯 | 一种薏仁奶 |
CN103100006A (zh) * | 2013-01-30 | 2013-05-15 | 无限极(中国)有限公司 | 一种具有降尿酸功能的中草药组合物 |
CN103190659A (zh) * | 2013-04-12 | 2013-07-10 | 康美药业股份有限公司 | 具有降压降脂和降糖作用的植物饮料及其制备方法和应用 |
CN103250821A (zh) * | 2013-04-17 | 2013-08-21 | 安徽省石台县日新茶叶实业有限公司 | 一种降脂减肥茶及其制备方法 |
Non-Patent Citations (2)
Title |
---|
中西医结合治疗高血脂症研究进展;陈汉阳;《现代中西医结合杂志》;20070910;第16卷(第26期);第3926-3929页 * |
薏苡仁防治代谢综合征;张子臻等;《中医杂志》;20110402;第52卷(第7期);第610-611页 * |
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