CN104523942B - 一种治疗阴道炎的外用制剂 - Google Patents
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Abstract
本发明属于中药领域，公开了一种治疗阴道炎的外用制剂，其特征在于，它由以下特定重量份的中药材制备而成：黄柏6-30、苦参6-30、白芍6-30、金铃子4-30、白芷6-30、轻粉6-30。在本发明特定的重量份配比之下，这六种中药材组合在一起能相互协调，发挥奇效，起到治疗妇科疾病的作用。
Description
技术领域
本发明属于医药技术领域，涉及一种治疗妇科疾病的外用制剂及其制备方法。
背景技术
妇科疾病是女性常见病、多发病，包括外阴疾病、阴道疾病、子宫疾病、盆腔疾病、输卵管疾病、卵巢疾病等。但由于许多人对妇科疾病缺乏应有的认识，缺乏对身体的保健，加之各种不良生活习惯等，使生理健康每况愈下，导致一些女性疾病缠身，且久治不愈，给正常的生活、工作带来极大的不便。
目前治疗妇科疾病的中药有很多例如：妇炎康复片，妇康口服液，金刚藤胶囊。公开的专利文献已有上百篇。但这些药物大多为口服制剂。
发明内容
本发明人经过长期的临床实验研究，提供了一种具有清热解毒、杀虫止痒治疗妇科疾病的外用制剂。
本发明治疗妇科疾病的外用制剂是在祖传秘方的基础上精心选择黄柏、苦参、白芍、金铃子、白芷、轻粉等六种中药材，按照特定的重量份配比制备而成，也只有在本发明特定的重量份配比之下，这六种中药材组合在一起才能相互协调，发挥奇效，起到治疗妇科疾病的作用。
故本发明公开了一种治疗妇科疾病的外用制剂，其特征在于，它由以下特定重量份的中药材制备而成：
黄柏6-30、苦参6-30、白芍6-30、金铃子4-30、白芷6-30、轻粉6-30。
优选地，它由以下特定重量份的中药材制备而成：
黄柏10-20、苦参10-20、白芍15-30、金铃子4-12、白芷6-12、轻粉6-18。
优选地，它由以下特定重量份的中药材制备而成：
黄柏16、苦参12、白芍20、金铃子10、白芷8、轻粉8。
方中：
黄柏：清热燥湿，泻火除蒸，解毒疗疮。用于湿热泻痢，黄疸，带下，热淋，脚气，痿{辟}，骨蒸劳热，盗汗，遗精，疮疡肿毒，湿疹瘙痒。
苦参：归心、肝、胃、大肠、膀胱经。清热燥湿，杀虫，利尿。用于热痢，便血，黄疸尿闭，赤白带下，阴肿阴痒，湿疹，湿疮，皮肤瘙痒，疥癣麻风；外治滴虫性阴道炎。
白芍：归肝、脾经。平肝止痛，养血调经，敛阴止汗。用于头痛眩晕，胁痛，腹痛，四肢挛痛，血虚萎黄，月经不调，自汗，盗汗。
金铃子：金铃子为楝科植物川楝的干燥成熟果实。苦，寒；有小毒。归肝、小肠、膀胱经。舒肝行气止痛，驱虫。用于胸胁、脘腹胀痛，疝痛，虫积腹痛。
白芷：归胃、大肠、肺经。散风除湿，通窍止痛，消肿排脓。用于感冒头痛，眉棱骨痛，鼻塞，鼻渊，牙痛，白带，疮疡肿痛。
轻粉：归大肠、小肠经。外用杀虫，攻毒，敛疮；内服祛痰消积，逐水通便。外治用于疥疮，顽癣，臁疮，梅毒，疮疡，湿疹。
本发明所述的妇科疾病为外阴疾病、阴道疾病、子宫疾病、输卵管疾病、卵巢疾病等。
所述的阴道疾病为阴道炎。
本发明治疗妇科疾病的外用制剂的制备方法为：称取所述重量份的中药材放入煎药器具内，加入药材总重量3-6倍量的纯净水，浸泡0.5-1小时，使其充分湿润，以利药汁充分煎出；用武火煮沸后再改用文火煎煮0.5-2小时，除去药渣，取汤分装，即得。
本发明治疗妇科疾病的外用制剂，组方精简，仅有6味中药材组成，原药来源充足易得、成本低廉。经临床实验验证，本发明治疗妇科疾病的外用制剂尤其适用于阴道炎的治疗，有疗程短，治愈率高，治愈后不复发等优点。
部分临床实验材料。
1、临床资料
依据临床症状和妇科检查确诊阴道炎志愿者300例。300例志愿者均是白带增多，或黄或臭，阴部瘙痒，阴道分泌物涂片镜检发现滴虫或霉菌的阴道炎患者。患者年龄21-52岁，平均年龄35岁。将全部患者随机、平均分成2组，治疗组和对照组各150例。两组症状、年龄、病程经统计学处理无显著性差异，具有可比性。
2、疗效标准
治愈：白带量及颜色转为正常，阴部不瘙痒，阴道分泌物涂片镜检未发滴虫或霉菌。
有效：白带量及颜色转为正常，阴部不瘙痒，阴道分泌物涂片镜检发现1-2个滴虫或霉菌。
无效：临床症状体征无改善，与治疗前相比无变化。
3、治疗方法
治疗组：称取黄柏16g、苦参12g、白芍20g、金铃子10g、白芷8g、轻粉8g，粉碎后，放入煎药器具内，加入药材总重量5倍量的纯净水，浸泡0.5小时，使其充分湿润，以利药汁充分煎出；用武火煮沸后再改用文火煎煮1小时，除去药渣，取汤，均分为两次用量。每天早、晚2次擦洗患处，每次擦洗3分钟；连续治疗10天。
对照组：给予常规复方甲硝唑栓治疗，连续治疗10天。
4、治疗结果
10天后，两组疗效见表1。
表1两组临床疗效
| 组别 | 例数 | 治愈 | 有效 | 无效 | 总有效率 |
| 治疗组 | 150 | 121(80.7％) | 24(16.0％) | 5 | 96.7％ |
| 对照组 | 150 | 67(44.6％) | 36(24.0) | 47 | 68.6％ |
本发明治疗妇科疾病的外用制剂对滴虫或霉菌的阴道炎具有非常好的治疗效果，经过10天的治疗，本发明外用制剂治疗组治愈率高达80.7％，总有效率高达96.7％，明显优于甲硝唑对照组，经过统计学分析，差异有统计学意义。
6个月后对治疗组121例痊愈患者进行回访，回访成功100例，未见复发病例。成功回访对照组治愈患者60例，复发30例，复发率为50％。
上述临床实验表明，本发明对阴道炎的治疗效果明显。相比西药治疗，具有疗程短，有效率高，治愈后不复发的优点，且本发明外用制剂，无刺激性，无不良反应。
具体实施方式
实施例l
处方(重量份配比)：
黄柏16、苦参12、白芍20、金铃子10、白芷8、轻粉8。
制备方法：
称取上述重量份的中药材，粉碎后放入煎药器具内，加入药材总重量4倍量的纯净水，浸泡1小时，使其充分湿润，以利药汁充分煎出；用武火煮沸后再改用文火煎煮1小时，除去药渣，取汤分装，即得。
实施例2
处方(重量份配比)：
黄柏6、苦参6、白芍6、金铃子6、白芷6、轻粉6。
制备方法：
称取上述重量份的中药材，粉碎后放入煎药器具内，加入药材总重量6倍量的纯净水，浸泡1小时，使其充分湿润，以利药汁充分煎出；用武火煮沸后再改用文火煎煮1小时，除去药渣，取汤分装，即得。
实施例3
处方(重量份配比)：
黄柏30、苦参30、白芍30、金铃子30、白芷30、轻粉30。
制备方法：
称取上述重量份的中药材，粉碎后放入煎药器具内，加入药材总重量6倍量的纯净水，浸泡1小时，使其充分湿润，以利药汁充分煎出；用武火煮沸后再改用文火煎煮1小时，除去药渣，取汤分装，即得。
实施例4
处方(重量份配比)：
黄柏10、苦参10、白芍15、金铃子4、白芷6、轻粉6。
制备方法：
称取上述重量份的中药材，粉碎后放入煎药器具内，加入药材总重量5倍量的纯净水，浸泡0.5小时，使其充分湿润，以利药汁充分煎出；用武火煮沸后再改用文火煎煮0.5小时，除去药渣，取汤分装，即得。
实施例5
处方(重量份配比)：
黄柏20、苦参20、白芍30、金铃子12、白芷12、轻粉18。
制备方法：
称取上述重量份的中药材，粉碎后放入煎药器具内，加入药材总重量5倍量的纯净水，浸泡1小时，使其充分湿润，以利药汁充分煎出；用武火煮沸后再改用文火煎煮1小时，除去药渣，取汤分装，即得。
实施例6
处方(重量份配比)：
黄柏14、苦参10-20、白芍16、金铃子10、白芷10、轻粉18。
制备方法：
称取上述重量份的中药材，粉碎后放入煎药器具内，加入药材总重量5倍量的纯净水，浸泡1小时，使其充分湿润，以利药汁充分煎出；用武火煮沸后再改用文火煎煮1小时，除去药渣，取汤分装，即得。
实施例7
处方(重量份配比)：
黄柏10、苦参10、白芍30、金铃子12、白芷12、轻粉6。
制备方法：
称取上述重量份的中药材，粉碎后放入煎药器具内，加入药材总重量6倍量的纯净水，浸泡1小时，使其充分湿润，以利药汁充分煎出；用武火煮沸后再改用文火煎煮1小时，除去药渣，取汤分装，即得。
以上所述仅为本发明的实施例，并非因此限制本发明的专利范围，凡是利用本发明说明书及权利要求书内容所作的等效结构或等效流程变换，或直接或间接运用在其他相关的技术领域，均同理包括在本发明的专利保护范围内。
Claims (3)
1.一种治疗阴道炎的外用制剂，其特征在于，由以下重量份的中药材制备而成：黄柏6-30、苦参6-30、白芍6-30、金铃子4-30、白芷6-30、轻粉6-30。
2.如权利要求1所述的治疗阴道炎的外用制剂，其特征在于，由以下重量份的中药材制备而成：黄柏10-20、苦参10-20、白芍15-30、金铃子4-12、白芷6-12、轻粉6-18。
3.如权利要求1所述的治疗阴道炎的外用制剂，其特征在于，由以下重量份的中药材制备而成：黄柏16、苦参12、白芍20、金铃子10、白芷8、轻粉8。
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| CN1839980A (zh) * | 2006-01-08 | 2006-10-04 | 杨峰 | 一种治疗妇科病、性病的药物及其制备方法 |
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| CN1839980A (zh) * | 2006-01-08 | 2006-10-04 | 杨峰 | 一种治疗妇科病、性病的药物及其制备方法 |
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