CN104523928B - A kind of traditional Chinese compound medicine for treating gout in poultry - Google Patents
A kind of traditional Chinese compound medicine for treating gout in poultry Download PDFInfo
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- CN104523928B CN104523928B CN201410813955.9A CN201410813955A CN104523928B CN 104523928 B CN104523928 B CN 104523928B CN 201410813955 A CN201410813955 A CN 201410813955A CN 104523928 B CN104523928 B CN 104523928B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
Abstract
The present invention discloses a kind of traditional Chinese compound medicine for treating gout in poultry.Purpose be to provide it is a kind of have no toxic side effect, noresidue, without irritability, do not produce the traditional Chinese compound medicine of drug resistance and treatment gout in poultry free from environmental pollution.A kind of traditional Chinese compound medicine for treating gout in poultry includes following parts by weight of component：10 20 parts of umbellate pore furgus, 10 30 parts of Poria cocos, 20 30 parts of dried orange peel, 10 20 parts of Lygodium japonicum, 20 30 parts of desmodium, 10 20 parts of ground bettle.The traditional Chinese compound medicine reasonable recipe for the treatment of gout in poultry provided by the invention is effective, prepare simple, effective ingredient of pelletizing after extraction is purer, and formula has given full play to the comprehensive therapeutic effect of Chinese medicine multicomponent, multiple location, Mutiple Targets, there is special efficacy and without side-effects and drug resistance to gout in poultry；Medicine will not produce hazard residue in food poultry meat, egg product, can also avoid largely using pathogenic microorganism caused by chemicals to develop immunity to drugs, livestock products medicament residue and the problems such as environmental pollution.
Description
Technical field
The present invention relates to a kind of traditional Chinese compound medicine, and in particular to a kind of traditional Chinese compound medicine for treating gout in poultry.
Background technology
Gout in poultry is hyperuricemia caused by a kind of protein metabolism disturbance.Its pathological characters is blood uric acid levels
Increase, lithate deposits in capsular ligament, articular cartilage, internal organ, renal tubule and ureter.Clinical manifestation is bradykinesia, leg,
Conjunctura swelling, apocleisis, weak, diarrhea, internal organs occur piebald kidney, urine output blockage or white lithate embolus,
Heart, liver surface have lime rock sample exudate.
In poultry farming (egg fowl, poultry), protein content is excessive in daily ration, calcium-magnesium content is excessive, farm's management level
Height differs, farm master be the addition protein of increasing economic efficiency excessive when nutriment, there is gout of poultry when have
Occur.Poultry growth rate, laying rate is caused to be decreased obviously, breeding income degradation, therefore farm master after such disease occurs
Generally all prevented, treated using the chemicals such as methenamine, ammonium chloride, colchicin, because its using it is simple, take effect
It hurry up.
But using for chemicals can make it that the medicament residue in poultry, birds, beasts and eggs is exceeded, this make it that poultry, egg are relevant
Food-processing industry seriously affects health, the life security of the mankind there are huge security risk.
Chinese herbal medicine is the ecosystem green plants that the mankind are applied to prophylactic treatment human diseases earliest, can play and prevent and cure diseases
Effect, it has the advantages that safe and nontoxic, noresidue, inexpensive, thing is beautiful.As people's living standard increasingly improves, health care meaning
Know enhancing, solve the basic living problems from pervious, till now fairly comfortable life-not only to have enough will more eat, eat healthy food, is green
Color food, ecosystem food, mass type has been turned to animal food demand by scalar type.The production of green animal food is just met
This needs of people are closed, the work such as Chinese herbal medicine not only has antibacterial anti-inflammatory, antiviral, inducing diaphoresis to bring down a fever, kidney-nourishing row stone, hepatic cholagogic
With, while rich in nutrition necessary to the livestock and poultry such as various active substance amino acid, protein, trace element, polysaccharide, vitamin in it
Component, improves livestock and poultry anti-stress ability, premunition, improves the production performance of livestock and poultry.The natural Chinese medicinal herb of ripe prescription is only with its
Special nontoxic pair, noresidue, without irritability, do not produce drug resistance and free from environmental pollution, become the new theme for developing stockbreeding.
The content of the invention
Have no toxic side effect the purpose of the invention is to providing one kind, noresidue, without irritability, do not produce drug resistance and not
Pollute the traditional Chinese compound medicine of the treatment gout in poultry of environment.
The present invention is achieved by the following technical solution：
A kind of traditional Chinese compound medicine for treating gout in poultry includes following parts by weight of component：10-20 parts of umbellate pore furgus, Poria cocos 10-
30 parts, 20-30 parts of dried orange peel, 10-20 parts of Lygodium japonicum, 20-30 parts of desmodium, 10-20 parts of ground bettle.
Above-mentioned each component details are as follows：
Umbellate pore furgus：Alias wild boar excrement, is On Polyporaceae umbellate pore furgus Polyporus umbellatus (Pers.) Fries's
Dry sclerotia, spring, the excavation of two season of autumn, removes silt, dry；
Poria cocos：For the dry sclerotia of On Polyporaceae Poria cocos, master contains Beta-pachymaran, accounts for dry weight 93%, and
Triterpene compound Pachymic acid, pachymic acid, 3- Betas-hydroxyl wool steroid trienic acid and sylvite, sterol, lecithin, choline,
Histidine etc.；
Dried orange peel：The pericarp of rutaceae orange and its drying and ripening of variety, containing hesperidine, mysoinositol, volatile oil
And VB1；
Lygodium japonicum：Alias left-hand rotation rattan ash, Lygodium japonicum, are Lygodiaceae plant Lygodium japonicum Lygodium japonicum
(Thunb.) the ripe spore of Sw..Autumn spore harvests when not falling off, and dries, raw to use；
Desmodium：The drying herb of Ofthe Primulaceae Lysimachia christinae, containing volatile oil, tannin, flavonoids sylvite；
Ground bettle：Alias ground beetle, tortoise, dustpan worm, ground beetle, native cuckold, the soft-shelled turtle, be Corydiidae eupolyphagasinensis walker
The female adult hirudo leech of Eupolyphaga sinensis Walker or polyphagaplancyi Steleophaga plancyi (Boleny), catch
After catching, put in boiling water and scald extremely, dry or dry use.
Umbellate pore furgus, Poria cocos in formula have dual regulation, and antidiuretic activity is presented to dewatering state body, and to water
Diuresis, thus selective and protectively promotion excretion, while effective ingredient wheat in umbellate pore furgus is then presented in swollen state body
Angle sterol chemical constitution is similar to hypoxanthine, is the competitive inhibitor of xanthine oxidase, can inhibit the oxidation of xanthine, subtracts
The formation of oliguresis acid.Poria cocos has good inhibiting effect to Escherichia coli, staphylococcus aureus and pseudomonas aeruginosa, controllable
The secondary arthritis of gout in poultry processed.And ground bettle then has and stronger attacks malicious analgesic activity.
In the present invention, do not use the rhizoma alismatis in the similar prescription of tradition, avoid rhizoma alismatis it is sweet it is light it is cold in nature caused by
The side effects such as chicken anorexia, the dried orange peel in being especially formulated are removed dampness by means of aromatics, and sharp gas strengthening the spleen and stomach, can strengthen while diuresis
Animal gastrointestinal tract function, not only avoids drug side-effect, but also adds medicine using effect.
It is further preferred that the compound medicine includes following parts by weight of component：15-20 parts of umbellate pore furgus, Poria cocos 15-25
Part, 20-25 parts of dried orange peel, 10-15 parts of Lygodium japonicum, 25-30 parts of desmodium, 15-20 parts of ground bettle.
It is further preferred that the compound medicine includes following parts by weight of component：15 parts of umbellate pore furgus, 15 parts of Poria cocos, dried orange peel
25 parts, 15 parts of Lygodium japonicum, 25 parts of desmodium, 15 parts of ground bettle.
Still more preferably, the compound medicine further includes the sucrose of 10-20 parts by weight.That is removed in medicine
Go outside foregoing each traditional Chinese medicinal components, further include the sucrose of 10-20 parts by weight, the sucrose is sweet flavourings and excipient, is adjusted
The palatability of medicine is saved, also drinking water easy to poultry uses.
The traditional Chinese compound medicine for the treatment of gout in poultry provided by the invention has the following advantages：
1st, reasonable recipe is effective, prepares simply, and effective ingredient of pelletizing after extraction is purer.According to traditional Chinese veterinarian's theory and now
For herbal pharmacology theory, preferable 6 kinds of medicines, and combined by preferable formula rate, give full play to Chinese medicine multicomponent, more
Position, the comprehensive therapeutic effect of Mutiple Targets, have gout in poultry special efficacy and without side-effects and drug resistance.
2nd, natural Chinese traditional medicines preparation toxic side effect is small, has no drug resistance, and will not be produced in food poultry meat, egg product harmful
Residual, can also avoid largely using pathogenic microorganism caused by chemicals to develop immunity to drugs, livestock products medicament residue and environment
The problems such as pollution.
Embodiment
With reference to specific embodiment, the present invention will be further described, but the protection domain of the product of the invention prepared is not
It is limited to embodiment.Chinese medicine umbellate pore furgus used, Poria cocos, dried orange peel, Lygodium japonicum, desmodium, ground bettle (medicinal drink in embodiment 1-3
Piece) prepared slices of Chinese crude drugs factory of Chongqing City is purchased from, deionized water solvent is made for hyperfiltration in purified water.
Embodiment 1
The first step：The decoction of Chinese medicine.Specially take umbellate pore furgus 10g, Poria cocos 10g, dried orange peel 20g, Lygodium japonicum 10g, desmodium
20g, ground bettle 10g, cleaning, section, add 4 times of amount purified waters to decoct 2 hours, filter to get filtrate 1；Add 2 times of amount purifying
Water decoct 1 it is small when, filter to get filtrate 2.
Second step：The concentration of decocting for Chinese herbal medicine liquid, alcohol precipitation.Specially merging filtrate 1 and the heating of filtrate 2 is concentrated into Chinese medicine amount ratio
It is 1 to decoct liquid volume:1, it is cooled to room temperature (26 DEG C or so), adds the ethanol that mass fraction is 95%, reach filtrate alcohol content
75%, be sufficiently stirred, refrigeration stand 24 it is small when, leaching supernatant, recycling ethanol to liquid is without ethanol flavor, after obtaining water decoction-alcohol sedimentation
Chinese medicinal liquor.
3rd step：Water sinks, is filling, sterilizing.Specially recycle and add water to equimultiple Chinese medicine weight without alcohol herb liquid after ethanol
Amount, adjusts pH value to 8.0 with 10% sodium hydroxide, is sufficiently stirred, when refrigeration standing 24 is small, leaching supernatant, supplements purifying
Water full dose, with 0.45 μm of membrane filtration, obtains A liquid.
4th step：A liquid is put into input spray drying tower, while adds the bonding granulation of 10g sucrose, it is finally dry using boiling
Dry stove drying whole grain to obtain the final product.
Embodiment 2
The first step：The decoction of Chinese medicine.Specially take umbellate pore furgus 15g, Poria cocos 15g, dried orange peel 25g, Lygodium japonicum 15g, desmodium
25g, ground bettle 15g, cleaning, section, add 4 times of amount purified waters to decoct 2 hours, filter to get filtrate 1；Add 2 times of amount purifying
Water decoct 1 it is small when, filter to get filtrate 2.
Second step：The concentration of decocting for Chinese herbal medicine liquid, alcohol precipitation.Specially merging filtrate 1 and the heating of filtrate 2 is concentrated into Chinese medicine amount ratio
It is 1 to decoct liquid volume:1, it is cooled to room temperature (26 DEG C or so), adds the ethanol that mass fraction is 95%, reach filtrate alcohol content
75%, be sufficiently stirred, refrigeration stand 24 it is small when, leaching supernatant, recycling ethanol to liquid is without ethanol flavor, after obtaining water decoction-alcohol sedimentation
Chinese medicinal liquor.
3rd step：Water sinks, is filling, sterilizing.Specially recycle and add water to equimultiple Chinese medicine weight without alcohol herb liquid after ethanol
Amount, adjusts pH value to 8.0 with 10% sodium hydroxide, is sufficiently stirred, when refrigeration standing 24 is small, leaching supernatant, supplements purifying
Water full dose, with 0.45 μm of membrane filtration, obtains A liquid.
4th step：A liquid is put into input spray drying tower, while adds the bonding granulation of 15g sucrose, it is finally dry using boiling
Dry stove drying whole grain to obtain the final product.
Embodiment 3
The first step：The decoction of Chinese medicine.Specially take umbellate pore furgus 20g, Poria cocos 20g, dried orange peel 30g, Lygodium japonicum 20g, desmodium
30g, ground bettle 20g, cleaning, section, add 4 times of amount purified waters to decoct 2 hours, filter to get filtrate 1；Add 2 times of amount purifying
Water decoct 1 it is small when, filter to get filtrate 2.
Second step：The concentration of decocting for Chinese herbal medicine liquid, alcohol precipitation.Specially merging filtrate 1 and the heating of filtrate 2 is concentrated into Chinese medicine amount ratio
It is 1 to decoct liquid volume:1, it is cooled to room temperature (26 DEG C or so), adds the ethanol that mass fraction is 95%, reach filtrate alcohol content
75%, be sufficiently stirred, refrigeration stand 24 it is small when, leaching supernatant, recycling ethanol to liquid is without ethanol flavor, after obtaining water decoction-alcohol sedimentation
Chinese medicinal liquor.
3rd step：Water sinks, is filling, sterilizing.Specially recycle and add water to equimultiple Chinese medicine weight without alcohol herb liquid after ethanol
Amount, adjusts pH value to 8.0 with 10% sodium hydroxide, is sufficiently stirred, refrigeration stand 24 it is small when,
Leaching supernatant, supplements purified water full dose, with 0.45 μm of membrane filtration, obtains A liquid.
4th step：A liquid is put into input spray drying tower, while adds the bonding granulation of 20g sucrose, it is finally dry using boiling
Dry stove drying whole grain to obtain the final product.
Traditional Chinese compound medicine prepared by embodiment 1 to 3 carries out accelerated stability test, and specific method is as follows：
1st, materials and methods：Example 1-3 treats the traditional Chinese compound medicine of gout in poultry, according to《Chinese veterinary pharmacopoeia》
The one annex medicine stability experimental method of version in 2010 carries out hot and humid strong acceleration by light experiment,
By commercially available back, 40 ± 2 DEG C of temperature, relative humidity 75 ± 5%, 4500 ± 500LX of illumination medicine stability
Placed 6 months in experimental box (Chongqing immortality laboratory apparatus factory), the 1st, 2,3,6 the end of month is separately sampled once during the experiment,
The color, pH value, content of parenteral solution are investigated.
2nd, result：It is shown in Table 1.As shown in Table 1, the traditional Chinese compound medicine for the treatment of gout in poultry of the invention is in accelerated test 6
After a month, color, pH value, each component content have no significant change, and have good stability,
Table 1 treats the Acceleration study result of the traditional Chinese compound medicine of gout in poultry
Traditional Chinese compound medicine made from embodiment 1 to 3 is subjected to clinical practice experiment, specific method is as follows：
1. materials and methods
1.1 medicine
Treat gout in poultry traditional Chinese compound medicine, using the embodiment of the present invention 1, embodiment 2, embodiment 3 sample.
1.2 case sources：Technical staff is in Hechuan Yunmen town laying hen and the clinical natural occurrence case of broiler chicken field collection.
1.3 case diagnosis：With natural cases according to epidemiology, clinical symptoms, pathological change, Laboratory Diagnosed.It is comprehensive
Analysis, is made a definite diagnosis.
1.4 implementation process：Case selection is carried out by test requirements document and implement to treat, every 500 by this seminar technical staff
The kg diet mixed feeding 100g of the present invention or drinking-water addition 100g of the present invention per 500L, it is 2-3 times daily, examination is recorded after being used in conjunction 5
Test result.
1.5 result judgement
Case criterion：
Cure：Suffer from poultry diease disease to be wholly absent, spirit, body temperature, appetite recover normal, and urine excrement is normal.
Effectively：Suffer from poultry diease disease to disappear substantially, spirit, body temperature, appetite make moderate progress, and urine excrement is normal.
It is invalid：Suffer from poultry diease disease not disappear, sb.'s illness took a turn for the worse, and urine stool colour, character are abnormal.
2. result：It is shown in Table 2, table 3.From table 2, table 3 it can be seen that the traditional Chinese compound medicine of the treatment gout in poultry of the present invention
There is good therapeutic effect, more than 98.0% is reached to young broiler chicken, laying hen gout effective percentage, cure rate is more than 92%.
Table 2 treats the broiler chicken clinical therapeutic efficacy statistical form of the traditional Chinese compound medicine of gout in poultry
| Numbering | Group | Cure % | Effective % | Invalid % |
| A | Blank group | 4.6 | 11 | 89 |
| B | Embodiment 1 | 92.3 | 98.4 | 1.6 |
| C | Embodiment 2 | 92.7 | 98.7 | 1.3 |
| D | Embodiment 3 | 92.2 | 98.9 | 1.1 |
Table 3 treats the laying hen clinical therapeutic efficacy statistical form of the traditional Chinese compound medicine of gout in poultry
| Numbering | Group | Cure % | Effective % | Invalid % |
| A | Blank group | 6.2 | 13.2 | 86.8 |
| B | Embodiment 1 | 93.6 | 98.3 | 1.7 |
| C | Embodiment 2 | 94.5 | 98.4 | 1.6 |
| D | Embodiment 3 | 94.6 | 98.1 | 1.9 |
Claims (3)
- A kind of 1. traditional Chinese compound medicine for treating gout in poultry, it is characterised in that：The compound medicine is by following parts by weight of component It is made：10-20 parts of umbellate pore furgus, 10-30 parts of Poria cocos, 20-30 parts of dried orange peel, 10-20 parts of Lygodium japonicum, 20-30 parts of desmodium, ground bettle 10-20 parts, the sucrose of 10-20 parts by weight.
- 2. traditional Chinese compound medicine according to claim 1, it is characterised in that：The compound medicine is by following parts by weight group Divide and be made：15-20 parts of umbellate pore furgus, 15-25 parts of Poria cocos, 20-25 parts of dried orange peel, 10-15 parts of Lygodium japonicum, 25-30 parts of desmodium, ground bettle 15-20 parts, the sucrose of 10-20 parts by weight.
- 3. traditional Chinese compound medicine according to claim 1, it is characterised in that：The compound medicine is by following parts by weight group Divide and be made：15 parts of umbellate pore furgus, 15 parts of Poria cocos, 25 parts of dried orange peel, 15 parts of Lygodium japonicum, 25 parts of desmodium, 15 parts of ground bettle, 10-20 weight The sucrose of part.
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| CN111228403B (en) * | 2020-02-11 | 2021-08-17 | 黑龙江中医药大学 | Traditional Chinese medicine preparation for preventing and/or treating acute gout attack and preparation method thereof |
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