CN104522038B - A kind of Pesticidal combination containing fipronil bisamide - Google Patents
A kind of Pesticidal combination containing fipronil bisamide Download PDFInfo
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- CN104522038B CN104522038B CN201410810109.1A CN201410810109A CN104522038B CN 104522038 B CN104522038 B CN 104522038B CN 201410810109 A CN201410810109 A CN 201410810109A CN 104522038 B CN104522038 B CN 104522038B
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- China
- Prior art keywords
- pesticidal combination
- fipronil bisamide
- diacloden
- cupric sulfate
- effect
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 239000005899 Fipronil Substances 0.000 title claims abstract description 65
- 229940013764 fipronil Drugs 0.000 title claims abstract description 65
- ZOCSXAVNDGMNBV-UHFFFAOYSA-N 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile Chemical compound NC1=C(S(=O)C(F)(F)F)C(C#N)=NN1C1=C(Cl)C=C(C(F)(F)F)C=C1Cl ZOCSXAVNDGMNBV-UHFFFAOYSA-N 0.000 title claims abstract description 64
- FTQWRYSLUYAIRQ-UHFFFAOYSA-N n-[(octadecanoylamino)methyl]octadecanamide Chemical compound CCCCCCCCCCCCCCCCCC(=O)NCNC(=O)CCCCCCCCCCCCCCCCC FTQWRYSLUYAIRQ-UHFFFAOYSA-N 0.000 title claims abstract description 64
- 230000000361 pesticidal effect Effects 0.000 title claims abstract description 38
- 229910000366 copper(II) sulfate Inorganic materials 0.000 claims abstract description 59
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 claims abstract description 58
- NWWZPOKUUAIXIW-DHZHZOJOSA-N (E)-thiamethoxam Chemical compound [O-][N+](=O)/N=C/1N(C)COCN\1CC1=CN=C(Cl)S1 NWWZPOKUUAIXIW-DHZHZOJOSA-N 0.000 claims abstract description 57
- 239000004480 active ingredient Substances 0.000 claims abstract description 5
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- 239000004530 micro-emulsion Substances 0.000 claims description 9
- 239000000839 emulsion Substances 0.000 claims description 8
- OILAIQUEIWYQPH-UHFFFAOYSA-N cyclohexane-1,2-dione Chemical compound O=C1CCCCC1=O OILAIQUEIWYQPH-UHFFFAOYSA-N 0.000 claims description 6
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims description 6
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 4
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- DSOOGBGKEWZRIH-UHFFFAOYSA-N nereistoxin Chemical compound CN(C)C1CSSC1 DSOOGBGKEWZRIH-UHFFFAOYSA-N 0.000 description 4
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- 210000000582 semen Anatomy 0.000 description 4
- 102000002322 Egg Proteins Human genes 0.000 description 3
- 108010000912 Egg Proteins Proteins 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
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- 239000011734 sodium Substances 0.000 description 3
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- 229910052938 sodium sulfate Inorganic materials 0.000 description 3
- 235000011152 sodium sulphate Nutrition 0.000 description 3
- 241001124076 Aphididae Species 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 241001498622 Cixius wagneri Species 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 241000819999 Nymphes Species 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- 241000125167 Rhopalosiphum padi Species 0.000 description 2
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- 239000011575 calcium Substances 0.000 description 2
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- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 description 2
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- ZEMPKEQAKRGZGQ-AAKVHIHISA-N 2,3-bis[[(z)-12-hydroxyoctadec-9-enoyl]oxy]propyl (z)-12-hydroxyoctadec-9-enoate Chemical compound CCCCCCC(O)C\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CC(O)CCCCCC)COC(=O)CCCCCCC\C=C/CC(O)CCCCCC ZEMPKEQAKRGZGQ-AAKVHIHISA-N 0.000 description 1
- WRCRFKLCWDBILI-UHFFFAOYSA-N 2-(dimethylamino)propane-1,3-dithiol;oxalic acid Chemical compound OC(=O)C(O)=O.CN(C)C(CS)CS WRCRFKLCWDBILI-UHFFFAOYSA-N 0.000 description 1
- CDMGNVWZXRKJNS-UHFFFAOYSA-N 2-benzylphenol Chemical compound OC1=CC=CC=C1CC1=CC=CC=C1 CDMGNVWZXRKJNS-UHFFFAOYSA-N 0.000 description 1
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- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 241001414720 Cicadellidae Species 0.000 description 1
- DKZLNHQOAWHHDR-UHFFFAOYSA-N ClC=1SC(=CN1)CC1(CC(C(=O)O)=CC(=C1)C)C(=O)O Chemical compound ClC=1SC(=CN1)CC1(CC(C(=O)O)=CC(=C1)C)C(=O)O DKZLNHQOAWHHDR-UHFFFAOYSA-N 0.000 description 1
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- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 239000005901 Flubendiamide Substances 0.000 description 1
- 229920001732 Lignosulfonate Polymers 0.000 description 1
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- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The present invention provides a kind of Pesticidal combination containing fipronil bisamide, and the active ingredient of described Pesticidal combination is made up of fipronil bisamide, Cupric sulfate and Diacloden, and the weight ratio of described fipronil bisamide, Cupric sulfate and Diacloden is 1～18:15～80:1～10.The present invention has notable synergistic effect and lasting effect, being above single result of use, calculate according to the co-toxicity coefficient formula of Sun Yunpei, the co-toxicity coefficient of the insecticides of each proportioning composition is 169.68-269.98, it is all higher than 120, there is obvious potentiation；Harm for insects such as preventing and treating Oryza sativa L., vegetable, fruit tree, Cotton Gossypii, Miao Lin, the Lepidoptera of flowers and other crops, Homopteras, excellent effect, lasting period are long, the crop preventive effect to root-knot nematode and pathogen can be significantly improved simultaneously, promote that crop tuber is grown and plant strain growth, strengthen the resistance of crop, improve the yield and quality of crop.
Description
Technical field
The invention belongs to technical field of pesticide, particularly relate to a kind of Pesticidal combination containing fipronil bisamide.
Background technology
China is large agricultural country, it is necessary to plants out with the cultivated area only accounting for the whole world 7% and supports the crop products accounting for the world 21% population, so crop products must could meet needs by high yield.But crops frequently suffer from the harm of disease pest and weed so that it is the underproduction reduction of income, wherein insect pest is bigger on crops impact.So pesticide serves as important role in ensureing higher yield of crops high receipts.
The selection of pesticide species to select pesticide species environmentally friendly, high-efficiency low-toxicity low-residual.Using a certain insecticide due to single, insect easily develops immunity to drugs, and causes that prevention effect is not good, causes single drug amount to sharply increase, and not only increases use cost, and contaminated environment.Present people all seek a kind of can reduce make consumption improve the mixed insecticide of prevention effect.
Diacloden (chemical name 3-(2-chloro-1,3-thiazole-5-ylmethyl)-5-methyl isophthalic acid, 3,5-oxadiazines-4-base fork (nitro) amine), it it is the second filial generation nicotinoids high-efficient low toxicity insecticide of a kind of brand new, insect is had stomach toxicity, tags and systemic activity, for foliar spray and soil root irrigation.Rapidly by interior suction after its dispenser, and it is transmitted to each position of plant, sucking pest such as aphid, plant hopper, leafhopper, aleyrodid etc. are had good preventive effect.
Fipronil bisamide (English name: flubendiamide, molecular formula: C23H22F7IN2O4S), belongs to Novel ortho benzenedicarboxamide insecticides, activates calcium release channel in blue Buddhist nun's alkali recipient cell, causes the runaway release of storage calcium ion.It it is the compounds acting on insect cell orchid Buddhist nun's alkali (Ryanodine) receptor few in number at present, lepidoptera pest is had wide spectrum preventive effect by it, and produce with existing insecticide no interactions resistance, it is extremely suitable for the Pest control for existing insecticide being produced resistance；And resistance of rainwater washing against, the hydrobiological toxicity such as Apis, Cyprinus carpio is very low, to there being beneficial insect there is no activity under general consumption, namely almost non-toxic, be conducive to popularization and application on the wet crops such as Oryza sativa L. with cereal crops.But owing to this medicine is imported medicine, use cost is higher, so to seek complex preparation to reduce its use cost.
Cupric sulfate is the analog of the nereistoxin of synthetic, enters and is quickly converted to nereistoxin or Dihydronereistoxin element in insect bodies.This medicine is acetylcholine competitive inhibitor, have stronger tag, stomach toxicity and Uptake and translocation effect, the larva of lepidoptera pest is had good prevention effect.Belong to bionic-type pesticide, natural enemy impact is little, non-resistant, without residual hazard, free from environmental pollution, it is the comparatively ideal medicament of comprehensive control insect pest.This medicament can prevent and treat the various pests on the crops such as Oryza sativa L., vegetable, Semen Tritici aestivi, Semen Maydis, Folium Camelliae sinensis, fruit tree effectively, particularly rice leaf roller, striped rice borer, yellow rice borer etc. is had specially good effect.To Fish low toxicity, but the toxicity of silkworm is big.Registering crop in China is Oryza sativa L., is used for preventing and treating snout moths larva.
Summary of the invention
Present invention aim to solve above-mentioned deficiency, it is provided that a kind of good disinsection effect, non-resistant, cost are low, and environment amenable insecticides.
In order to achieve the above object, the present invention provides a kind of Pesticidal combination containing fipronil bisamide, it is characterized in that: the active ingredient of described Pesticidal combination is made up of fipronil bisamide, Cupric sulfate and Diacloden, the weight ratio of described fipronil bisamide, Cupric sulfate and Diacloden is 1～18:15～80:1～10.
The preferred version of such scheme is, possibly together with the synergist of account for Pesticidal combination gross weight 1～5% in described Pesticidal combination.
More preferably scheme is, described synergist is organosilicon, cyclohexanedione or ketopyrrolidine.
The preferred version of such scheme is, the gross weight of described active ingredient accounts for the 20～92% of Pesticidal combination weight.
The preferred version of such scheme is, containing agriculturally acceptable surfactant and carrier in described Pesticidal combination.
The preferred version of such scheme is, the dosage form of described Pesticidal combination is aqueous emulsion, microemulsion, wettable powder, suspending agent, water dispersible granules or soluble granule.
Pesticidal preparations is to need to select suitable adjuvant to prepare into preparation with pesticide original medicine through formula test just can be applied on Target crops for parasite killing.
nullWherein，Described surfactant is alkylphenol polyoxyethylene、Fatty alcohol-polyoxyethylene ether、Phenethyl phenol polyethenoxy ether、Phenethyl phenol polyethenoxy polyethenoxy ether、Oleum Ricini ethylene oxide adduct、Alkylphenol polyoxyethylene formaldehyde condensation products、Alkylphenol polyoxyethylene phosphate ester、Phenethyl phenol polyethenoxy ether phosphate、Ben-zylphenol Polyoxyethyl Ether、Polyoxyethylene carboxylate (span)、Calcium dodecyl benzene sulfonate、Dodecylbenzene sodium sulfonate、Lignosulfonates、NNO、NO、MF、ZS—1、Sodium lauryl sulphate、Pull open powder、N-Methyl fatty acyl taurines sodium、Alkylphenol polyoxyethylene formaldehyde condensation products sulfate、Tea seed cake powder、Saponin、Lignosulfite、Aliphatic alcohol sulfate、Penetrant t、Penetrating agent OT、JFC、Fatty acid amide N N-methyltaurine sodium salt、Polyoxyethylenated alcohol sodium sulfate.
Described filler and auxiliary agent can be any addible components, are configured to each application target final products with active constituent ethofenprox and fipronil bisamide, such as the preparation of suspending agent, wettable powder, water dispersible granules or other dosage forms.
Certainly, the present invention can also include other functional aids such as antifreeze, thickening agent, stabilizer, defoamer, disintegrating agent.
Any of the above surfactant, filler and auxiliary agent etc. are all commercially available.
The Pesticidal combination of the present invention is mainly used in the harm of the insects such as preventing and treating Oryza sativa L., vegetable, fruit tree, Cotton Gossypii, Miao Lin, the Lepidoptera of flowers and other crops, Homoptera.Its preventive effect is higher than the preventive effect of alone fipronil bisamide or Cupric sulfate or Diacloden, and can reduce auxiliary dosage.Additionally, synergist cyclohexanedione, ketopyrrolidine and organosilicon all can be obviously improved the moistening of fipronil bisamide, Cupric sulfate and Diacloden, spread, dispersion, delay and permeance property, reduce spray liquor (air-flow) with the wind drift, prevent or alleviate the infringement to contiguous sensitive crop etc., be beneficial to medicinal liquid sprawl on blade face and stick, reduce ultraviolet to pesticidal preparations in the decomposition of effective ingredient, reach to extend drug effect effect duration, improve its biological activity；Suppress or weaken the anti-poisoning effect of removing toxic substances to pesticide activity of the target weeds, delaying medicament accretion rate in controlling object, thus increasing biological preventive effect.So after this Pesticidal combination increases synergist, being remarkably improved its insecticidal effect.
Processing technique and the equipment of the various preparation of the present composition are known.Processing such as suspending agent is by formula proportion, after enough pesticide activity components, surfactant, defoamer, thickening agent or filler and part water being mixed, through high speed shear, wet method sand milling, obtains semi-finished product, adds the filtration of water mix homogeneously and get product after analysis；Capital equipment is to have batching kettle, colloid mill or homogeneous mixer, sand mill.
The processing of wettable powder is pesticide activity component, auxiliary agent, filler to be mixed in proportion after comminution by gas stream and remix prepared wettable powder；Capital equipment has mixer, jet mill.
The processing of water dispersible granules is pesticide activity component, auxiliary agent, filler to be mixed in proportion and carry out the prepared water dispersible granules of pelletize then through granulating agent after comminution by gas stream；Capital equipment has mixer, jet mill, granulating agent etc..
The present composition can be used by commonsense method, does stem and leaf process as added water spray, it is possible to directly spread fertilizer over the fields.The amount of application of the present invention changes with weather condition and crop condition, it is possible to by using suitable dosage form to reach to prevent and treat purpose.
The invention has the beneficial effects as follows:
1, owing to fipronil bisamide and Cupric sulfate, Diacloden are entirely different to the mechanism of action of target pest, make insecticides by composite for three, there is notable synergistic effect and lasting effect, be above single result of use；Further, since Cupric sulfate yield is big, less costly, so production cost can be reduced；Co-toxicity coefficient formula according to Sun Yunpei calculates, and the co-toxicity coefficient of the Pesticidal combination of the present invention is between 169.68-269.98, is all higher than 120, has obvious potentiation；
2, the Pesticidal combination insecticidal activity of the present invention is strong, insecticidal spectrum is wide, harm for insects such as preventing and treating Oryza sativa L., vegetable, fruit tree, Cotton Gossypii, Miao Lin, the Lepidoptera of flowers and other crops, Homopteras, excellent effect, lasting period are long, the crop preventive effect to root-knot nematode and pathogen can be significantly improved simultaneously, promote that crop tuber is grown and plant strain growth, strengthen the resistance of crop, improve the yield and quality of crop.
3, the present invention is through scientific matching, and consumption is less than each single dose dosage, it is possible to greatly alleviate and various natural enemies are affected, and continues pest resistance, environmentally friendly.
Detailed description of the invention
Present invention specific examples below is described in detail, but the present invention is only limitted to absolutely not these examples, and in all formula, percentage ratio is all weight percentage.
One, pharmaceutical formulation example
Embodiment 1:78% soluble granula
Fipronil bisamide 5%, Cupric sulfate 65%, Diacloden 8%, cyclohexanedione 4.5%, sodium lignin sulfonate 3%, sodium lauryl sulphate 1.5%, sodium sulfate polishing are to 100%.
Embodiment 2:90% soluble granula
Fipronil bisamide 10%, Cupric sulfate 75%, Diacloden 5%, pull open powder 2.5%, NP-91.5%, white carbon polishing to 100%.
Embodiment 3:92% soluble powder
Fipronil bisamide 12%, Cupric sulfate 70%, Diacloden 10%, organosilicon 5%, OP-101.5%, alkylbenzenesulfonate 3%, ammonium sulfate polishing are to 100%.
Embodiment 4:75.6% wettable powder
Fipronil bisamide 18%, Cupric sulfate 56%, Diacloden 1.6%, di-2-ethylhexylphosphine oxide bitter edible plant sodium sulfonate 2.5%, lauryl sulphate acid calcium 2.5%, fine particle calcium carbonate polishing are to 100%.
Embodiment 5:83.5% wettable powder
Fipronil bisamide 5%, Cupric sulfate 68%, Diacloden 10.5%, calcium lignosulfonate 3.5%, alkylbenzenesulfonate 1.5%, Kaolin polishing are to 100%.
Embodiment 6:90% water dispersible granules
Fipronil bisamide 4.5%, Cupric sulfate 78%, Diacloden 7.5%, ketopyrrolidine 2.5%, NP-103%, dodecyl sodium sulfate 1.5%, sodium sulfate polishing are to 100%.
Embodiment 7:80.5% water dispersion granule
Fipronil bisamide 15%, Cupric sulfate 64%, Diacloden 1.5%, polysorbate60 3%, alkylbenzenesulfonate 1.5%, attapulgite polishing are to 100%.
Embodiment 8:64% water dispersion granule
Fipronil bisamide 3%, Cupric sulfate 58%, Diacloden 3%, sodium lignin sulfonate 2.5%, pull open powder 1.5%, white carbon polishing to 100%.
Embodiment 9:22.5% microemulsion
Fipronil bisamide 1.5%, Cupric sulfate 20%, Diacloden 1%, organosilicon 2%, agriculture breast 603#8%, NP-915%, water polishing are to 100%.
Embodiment 10:26.5% microemulsion
Fipronil bisamide 2%, Cupric sulfate 22%, Diacloden 2.5%, cyclohexanedione 1%, Nongru-700 #10%, polysorbas20 12%, water polishing are to 100%.
Embodiment 11:28% microemulsion
Fipronil bisamide 1%, Cupric sulfate 25%, Diacloden 2%, Tween 80 6%, agriculture breast 602#10%, water polishing are to 100%.
Embodiment 12:20.5% aqueous emulsion
Fipronil bisamide 1.5%, Cupric sulfate 15%, Diacloden 4%, ethylene glycol/isopropanol 10%, agriculture breast 1603#10%, water polishing are to 100%.
Embodiment 13:26% aqueous emulsion
Fipronil bisamide 4%, Cupric sulfate 18%, Diacloden 4%, ethanol/ethylene glycol 12%, Tween 80 8%, water polishing are to 100.
Embodiment 14:55.5% suspending agent
Fipronil bisamide 4.5%, Cupric sulfate 45%, Diacloden 6%, NPE 2%, sodium lauryl sulphate 1%, water polishing are to 100%.
Embodiment 15:42.7% suspending agent
Fipronil bisamide 2.5%, Cupric sulfate 38.2%, Diacloden 2%, di-2-ethylhexylphosphine oxide bitter edible plant sodium sulfonate 2.5%, alkylbenzenesulfonate 2%, water polishing are to 100%.
Two, co-toxicity coefficient experiment
In order to verify the Pesticidal combination of the present invention effect to preventing and treating rice-stem borer, inventor has carried out mutual composite potentiation research with effective active composition fipronil bisamide, Cupric sulfate, Diacloden.Experiment adopts rice-stem borer for test object, method particularly includes:
1, test method
1) test medicine: fipronil bisamide (95% former medicine) is produced by Nihon Nihyaku Co., Ltd; Cupric sulfate (95% former medicine) Hefei Fine Chemical Works produces; Diacloden (98% former medicine) is produced by Anhui Guangxin Agricultural Chemicals Co., Ltd., and synergist (organosilicon, cyclohexanedione, ketopyrrolidine) is produced by Shanghai Hui Jin Chemical trade company limited.
2) subjects: rice-stem borer ovum incubates the Sheng phase.
3) test method: with reference to " People's Republic of China (PRC) agricultural industry criteria NY/T1154.7 2006 ".Examination worm is pick up from field in the healthy growth of warm indoor raising, uniformity, access in the culture dish that diameter is 12 putting the tender Seedling of Oryza sativa L. and cabbage leaves (processing with cotton ball moisturizing), each culture dish connects worm 30, with capillary tube dropper, medicinal liquid is dripped on the pronotary trying worm, every 0.1 μ l.General each process sets 4-5 Concentraton gradient.Every concentration repeats 4 times, and the culture dish processed is put into 25 DEG C, cultivates in 12H/12H illumination box, within 48 hours, checks dead borer population, calculates mortality rate, blank spray equivalent clear water.
4) analyze: carry out statistical analysis with DPS data processor software, calculate the LC of each medicament50Value, evaluates the reagent agent activity to examination worm with this.
The co-toxicity coefficient (CTC value) of mixture calculates by following equation:
CTC=(ATI/TTI) * 100
Wherein: ATI=S/M
TTI=TIA × PA+TIB × PB
In formula: CTC co-toxicity coefficient；ATI mixture actual measurement toxicity index；TTI mixture theory toxicity index；S standard pesticide agent LC50, unit is milligrams per liter (mg/L)；The LC of M mixture50, unit is milligrams per liter (mg/L)；TIA A medicament toxicity index；PA A medicament percentage composition in mixture, unit is percentage rate (%)；TIB B medicament toxicity index；PB B medicament percentage composition in mixture, unit is percentage rate (%).
When co-toxicity coefficient CTC >=120 of complex preparation show as potentiation；CTC≤80 show as antagonism, and 80 < CTC < 120 show as summation action.
2, taking in pharmaceutical formulation example 1～15 pair of rice-stem borer ovum to incubate the Sheng phase and test, measure its toxicity index, then calculate the co-toxicity coefficient of its each proportioning by the co-toxicity coefficient formula of Sun Yunpei, result is in Table 1.
Table 1: co-toxicity coefficient result
Toxicity Determination result shows: rice-stem borer is had good toxic effect by the Pesticidal combination of the present invention, wherein, fipronil bisamide, Cupric sulfate, Diacloden co-toxicity coefficient between 169.68-269.98, be all higher than 120, all have notable potentiation.From table 1 can, the co-toxicity coefficient of Pesticidal combination is different and present difference with compound proportion, in 15 the different mixing match measured, with fipronil bisamide: Cupric sulfate: the weight ratio of Diacloden is the most obvious for 12:70:10 effect, co-toxicity coefficient reaches 269.24.And increasing synergist in the composition, the insecticidal effect of compositions is also had obvious potentiation by it.
Three, field efficacy demonstration test
Embodiment 16:
Trial crops and object: rice-stem borer
Test medicine: embodiment 3 Chinese medicine, 92% soluble granula (12% fipronil bisamide 70% Cupric sulfate 10% Diacloden 5% organosilicon) (our company's production)；
Comparison medicament: 42% fipronil bisamide suspension agent (Nihon Nihyaku Co., Ltd's production)；
95% Cupric sulfate wettable powder (Hefei Fine Chemical Works)；
75% Diacloden water dispersible granules (Anhui Guangxin Agricultural Chemicals Co., Ltd.)
Spraying time and method: test then dispenser on June 20 in 2013, at that time Oryza sativa L. elongation-heading stage of an established trade mark, incubate the Sheng phase for first generation striped rice borer ovum, by every mu of dosage 20 grams, then water preparating liquid 50KG sprayed, do not rain after dispenser in 24 hours.
Investigation: parallel saltatory samples, each community investigates 50 clumps, adds up the withered heart (sheath) number and total strain number, and control time carries out after the killed abundant performance of blank, namely after dispenser 15 days, the withered heart (sheath) rate and prevention effect (see table 2) are investigated.
Table 2: rice-stem borer efficiency test table
Drug effect computational methods:
Prevention effect=(the check plot withered heart (sheath) the rate treatment region withered heart (sheath) the rate)/check plot withered heart (sheath) rate * 100%
Interpretation of result: the preventive effect of 92% soluble granula (12% fipronil bisamide 70% Cupric sulfate 10% Diacloden 5% organosilicon SG) reaches 95.35%, and the preventive effect of 42% fipronil bisamide suspension agent and 95% Cupric sulfate wettable powder is 73.48% and 81.32%, the preventive effect of 75% Diacloden water dispersible granules is only 10.70%.Illustrate that 92% soluble granula of the present invention prevention effect to rice-stem borer is apparently higher than fipronil bisamide, Cupric sulfate and Diacloden single dose effect, therefore has good popularizing application prospect.
Embodiment 17:
Trial crops and object: Yellow Rice Borer
Test medicine: compositions in embodiment 5,83.5% wettable powder (5% fipronil bisamide 68% Cupric sulfate 10.5% Diacloden) (our company's production)；
Comparison medicament: 42% fipronil bisamide suspension agent (Nihon Nihyaku Co., Ltd's production)；
95% Cupric sulfate wettable powder (Hefei Fine Chemical Works)；
75% Diacloden water dispersible granules (Anhui Guangxin Agricultural Chemicals Co., Ltd.)
Spraying time and method: test then dispenser on July 20 in 2013, Oryza sativa L. was in the heading cut phase at that time, by every mu of dosage 30 grams, then water preparating liquid 50KG is sprayed, does not rain after dispenser in 24 hours.
Investigate: the sampling of parallel saltatory, each community investigation 50 clumps, add up dead ears strain number every square metre interior and worm head number of living, within after dispenser 15 days, investigate dead ears strain numbers and worm head number alive and add up prevention effect (see table 3).
Table 3: preventing and treating yellow rice borer test table
Drug effect computational methods:
Prevention effect=(check plot dead ears rate treatment region dead ears rate)/check plot dead ears rate * 100%
Live worm head number * 100% in decline rate=(check plot worm head number treatment region alive worm head number alive)/check plot
Interpretation of result: the preventive effect of 83.5% wettable powder reaches 93.97%, Revision insect recluced rate reaches 96.61%；And the preventive effect of 42% fipronil bisamide suspension agent and 95% Cupric sulfate wettable powder is 63.79% and 66.38%, Revision insect recluced rate is 76.27% and 62.71%, and the preventive effect of 75% Diacloden water dispersible granules is only 25.00%, and Revision insect recluced rate is 40.68%.Illustrate that the prevention effect of 83.5% WP on Rice yellow rice borer of the present invention is apparently higher than fipronil bisamide, Cupric sulfate and Diacloden single dose effect, therefore has good popularizing application prospect.
Embodiment 18:
Trial crops and object: Oryza sativa L. rice leaf roller
Test medicine: embodiment 6 Chinese medicine, 90% water dispersible granules (4.5% fipronil bisamide 78% Cupric sulfate 7.5% Diacloden 2.5% ketopyrrolidine) (our company's production)；
Comparison medicament: 42% fipronil bisamide suspension agent (Nihon Nihyaku Co., Ltd's production)；
95% Cupric sulfate wettable powder (Hefei Fine Chemical Works)；
75% Diacloden water dispersible granules (Anhui Guangxin Agricultural Chemicals Co., Ltd.)
Spraying time and method: test then dispenser on June 12 in 2013, Oryza sativa L. was just locating tillering stage at that time, for third generation rice leaf roller 1～2 instar larvae peak period, by every mu of dosage 30 grams, again water preparating liquid 50KG is sprayed, do not rain in 24 hours after dispenser.
Investigation: parallel saltatory samples, investigate whole blades of 50 clumps, each community, win all the old and new's worm bags, record total strain number, wraparound number, then stripping bag records each instar larvae number, control time carries out after the killed abundant performance of blank, namely after dispenser 15 days, investigation decline rate and prevention effect (see table 4).
Table 4: Oryza sativa L. rice leaf roller efficiency test table
| Process | Leaf roll number/m2 | Leaf roll preventive effect % | Live worm head number/m2 | Decline rate % |
| 90% water dispersible granules | 0.05 | 95.42 | 0.02 | 96.08 |
| 42% fipronil bisamide suspension agent | 0.37 | 66.86 | 0.14 | 71.43 |
| 75% Diacloden water dispersible granules | 0.67 | 36.99 | 0.29 | 45.28 |
| 95% Cupric sulfate wettable powder | 0.69 | 38.94 | 0.25 | 51.92 |
| CK clear water compares | 1.09 | \ | 0.78 | \ |
Drug effect computational methods:
Prevention effect=(check plot leaf roll rate treatment region leaf roll rate)/check plot leaf roll rate * 100%
Live worm head number * 100% in decline rate=(check plot worm head number treatment region alive worm head number alive)/check plot
Interpretation of result: the preventive effect of 90% water dispersible granules reaches 95.42%, Revision insect recluced rate reaches 96.08%.And the preventive effect of 42% fipronil bisamide suspension agent is 66.86%, Revision insect recluced rate is 71.43%；The preventive effect of 75% Diacloden water dispersible granules and 95% Cupric sulfate wettable powder is only 36.99%, 38.94% respectively, Revision insect recluced rate respectively 45.28% and 51.92%.Illustrate that 90% water dispersible granules of the present invention prevention effect to rice leaf roller is apparently higher than fipronil bisamide, Cupric sulfate and Diacloden single dose effect, therefore has good popularizing application prospect.
Embodiment 19:
Trial crops and object: Brassica campestris L diamondback moth
Test medicine: embodiment 11 Chinese medicine, 28% microemulsion (1% fipronil bisamide 25% Cupric sulfate 2% Diacloden) (our company's production)；
Comparison medicament: 42% fipronil bisamide suspension agent (Nihon Nihyaku Co., Ltd's production)；
95% Cupric sulfate wettable powder (Hefei Fine Chemical Works)；
75% Diacloden water dispersible granules (Anhui Guangxin Agricultural Chemicals Co., Ltd.)
Spraying time and method: test then dispenser on October 20 in 2013, at that time Brassica Napus Seedling 8-10 leaf, diamondback moth 1～2 instar larvae peak period, by every mu of dosage 100ml, then spray to water preparating liquid 50KG, do not rain after dispenser in 24 hours.
Investigation: parallel saltatory samples, investigate whole blades of 50 Brassica campestris Ls in each community, win all by moth food blade, record each instar larvae number on total strain number, the insect pest number of blade and blade, control time carries out after the killed abundant performance of blank, namely after dispenser 15 days, investigation decline rate and prevention effect (see table 5).
Table 5: Brassica campestris L diamondback moth efficiency test table
| Process | The moth food number of sheets/m2 | Protect leaf preventive effect % | Live worm head number/m2 | Decline rate % |
| 28% microemulsion | 0.06 | 94.45 | 0.02 | 95.92 |
| 42% fipronil bisamide suspension agent | 0.38 | 63.92 | 0.14 | 70.83 |
| 75% Diacloden water dispersible granules | 0.78 | 24.60 | 0.35 | 31.37 |
| 95% Cupric sulfate wettable powder | 0.42 | 60.44 | 0.15 | 68.09 |
| CK clear water compares | 1.07 | \ | 0.78 | \ |
Drug effect computational methods:
Prevention effect=(check plot moth food rate treatment region moth food rate)/check plot moth food rate * 100%
Live worm head number * 100% in decline rate=(check plot worm head number treatment region alive worm head number alive)/check plot
Interpretation of result: the preventive effect of 28% microemulsion reaches 94.45%, Revision insect recluced rate reaches 95.92%.And the preventive effect of 42% fipronil bisamide suspension agent and 95% Cupric sulfate wettable powder respectively 63.92%, 60.44%, Revision insect recluced rate then respectively 70.83%, 68.09%；The preventive effect of 75% Diacloden water dispersible granules is only 24.60% respectively, Revision insect recluced rate respectively 31.37%.Illustrate that 28% microemulsion prevention effect to diamondback moth is apparently higher than fipronil bisamide, Cupric sulfate and Diacloden single dose effect, therefore has good popularizing application prospect.
Embodiment 20:
Trial crops and object: wheat aphid
Test medicine: embodiment 13 Chinese medicine, 26% aqueous emulsion (4% fipronil bisamide 18% Cupric sulfate 4% Diacloden) (our company's production)；
Comparison medicament: 42% fipronil bisamide suspension agent (Nihon Nihyaku Co., Ltd's production)；
95% Cupric sulfate wettable powder (Hefei Fine Chemical Works)；
75% Diacloden water dispersible granules (Anhui Guangxin Agricultural Chemicals Co., Ltd.)
Spraying time and method: test then dispenser on March 15 in 2012, Semen Tritici aestivi was just locating tillering regularity, aphid nymph peak period at that time, by every mu of dosage 100ml, then water preparating liquid 50KG is sprayed, does not rain after dispenser in 24 hours.
Investigation: parallel saltatory samples, and investigates 50 clumps, each community Semen Tritici aestivi, adds up yellow fleck strain number every square metre interior, investigates yellow fleck strain numbers and adds up prevention effect (see table 6) for after dispenser 15 days.
Table 6: Brassica campestris L diamondback moth efficiency test table
| Process | The macula lutea number of sheets/m before medicine2 | The macula lutea number of sheets/m after medicine2 | Macula lutea rate % | Preventive effect % |
| 26% aqueous emulsion | 5.21 | 0.07 | 1.34 | 93.53 |
| 42% fipronil bisamide suspension agent | 5.14 | 0.89 | 17.32 | 16.66 |
| 75% Diacloden water dispersible granules | 4.88 | 0.24 | 4.92 | 76.33 |
| 95% Cupric sulfate wettable powder | 5.03 | 0.78 | 15.51 | 25.36 |
| CK clear water compares | 5.15 | 1.07 | 20.78 | \ |
Drug effect computational methods:
Prevention effect=(check plot macula lutea rate treatment region macula lutea rate)/check plot macula lutea rate * 100%
Interpretation of result: the preventive effect of 26% aqueous emulsion reaches 93.53%, the preventive effect of 75% Diacloden water dispersible granules is 76.33%.The preventive effect of 42% fipronil bisamide suspension agent and 95% Cupric sulfate wettable powder is only 16.66%, 25.36%.Illustrate that 26% aqueous emulsion prevention effect to wheat aphid is apparently higher than fipronil bisamide, Cupric sulfate and Diacloden single dose effect, therefore has good popularizing application prospect.
Embodiment 21:
Trial crops and object: rice hoppers
Test medicine: embodiment 14 Chinese medicine, 55.5% suspending agent (2.5% fipronil bisamide 38.2% Cupric sulfate 2% Diacloden) (our company's production)；
Comparison medicament: 42% fipronil bisamide suspension agent (Nihon Nihyaku Co., Ltd's production)；
95% Cupric sulfate wettable powder (Hefei Fine Chemical Works)；
75% Diacloden water dispersible granules (Anhui Guangxin Agricultural Chemicals Co., Ltd.)
Spraying time and method: test then dispenser on August 05 in 2013, Oryza sativa L. was just locating heading stage, planthopper nymph peak period at that time, by every mu of dosage 50ml, then water preparating liquid 50KG is sprayed, does not rain after dispenser in 24 hours.
Investigation: parallel saltatory samples, and investigates 50 clumps, each community Oryza sativa L., adds up black every square metre interior or brown speckle rice strain number, investigates black or brown speckle rice strain number and adds up prevention effect (see table 7) for after dispenser 15 days.
Table 7: rice hoppers efficiency test table
Drug effect computational methods:
Prevention effect=(check plot pityriasis simplex rate treatment region pityriasis simplex rate)/check plot pityriasis simplex rate * 100%
Interpretation of result: the preventive effect of 55.5% suspending agent reaches 93.90%, and the preventive effect of 75% Diacloden water dispersible granules is 78.12%.The preventive effect of 42% fipronil bisamide suspension agent and 95% Cupric sulfate wettable powder is only 23.46%, 19.77%.Illustrate that 55.5% suspending agent prevention effect to rice hoppers is apparently higher than fipronil bisamide, Cupric sulfate and Diacloden single dose effect, therefore has good popularizing application prospect.
From above-mentioned six field test demonstration tests, the insects such as Oryza sativa L., vegetable, fruit tree, Cotton Gossypii, Miao Lin, the Lepidoptera of flowers and other crops, Homoptera are had effect of preventing and kill off significantly by the Pesticidal combination that fipronil bisamide Cupric sulfate Thiamethoxam compound is made, preventive effect is substantially better than single dose, and effective ingredient consumption significantly reduces, to crop safety.
Claims (6)
1. the Pesticidal combination containing fipronil bisamide, it is characterized in that: the active ingredient of described Pesticidal combination is made up of fipronil bisamide, Cupric sulfate and Diacloden, the weight ratio of described fipronil bisamide, Cupric sulfate and Diacloden is 1～18:15～80:1～10.
2. Pesticidal combination according to claim 1, it is characterised in that: possibly together with the synergist of account for Pesticidal combination gross weight 1～5% in described Pesticidal combination.
3. Pesticidal combination according to claim 2, it is characterised in that: described synergist is organosilicon, cyclohexanedione or ketopyrrolidine.
4. Pesticidal combination according to claim 1, it is characterised in that: the gross weight of described active ingredient accounts for the 20～92% of Pesticidal combination weight.
5. Pesticidal combination according to claim 1, it is characterised in that: containing agriculturally acceptable surfactant and carrier in described Pesticidal combination.
6. Pesticidal combination according to claim 1, it is characterised in that: the dosage form of described Pesticidal combination is aqueous emulsion, microemulsion, wettable powder, suspending agent, water dispersible granules or soluble granule.
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| CN104522038A CN104522038A (en) | 2015-04-22 |
| CN104522038B true CN104522038B (en) | 2016-07-06 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101755814A (en) * | 2009-11-17 | 2010-06-30 | 陕西汤普森生物科技有限公司 | Pesticidal composition containing thiamethoxam and flubendiamide |
| CN101810172A (en) * | 2010-04-23 | 2010-08-25 | 江苏龙灯化学有限公司 | Insecticidal composition containing fluorin inspect bisamide and monosultap |
| CN102805097A (en) * | 2012-08-13 | 2012-12-05 | 广西汇丰生物科技有限公司 | Granules containing monosultap and thiamethoxam |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101755814A (en) * | 2009-11-17 | 2010-06-30 | 陕西汤普森生物科技有限公司 | Pesticidal composition containing thiamethoxam and flubendiamide |
| CN101810172A (en) * | 2010-04-23 | 2010-08-25 | 江苏龙灯化学有限公司 | Insecticidal composition containing fluorin inspect bisamide and monosultap |
| CN102805097A (en) * | 2012-08-13 | 2012-12-05 | 广西汇丰生物科技有限公司 | Granules containing monosultap and thiamethoxam |
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| CN104522038A (en) | 2015-04-22 |
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Denomination of invention: A insecticidal composition containing fluconamide Granted publication date: 20160706 Pledgee: China Merchants Bank Limited by Share Ltd. Hefei branch Pledgor: ANHUI ZHONGBANG BIOLOGICAL ENGINEERING Co.,Ltd. Registration number: Y2024980011410 |