CN104519858B - 包含环氧化合物、第一酸和第二酸的漱口水 - Google Patents
包含环氧化合物、第一酸和第二酸的漱口水 Download PDFInfo
- Publication number
- CN104519858B CN104519858B CN201280075231.8A CN201280075231A CN104519858B CN 104519858 B CN104519858 B CN 104519858B CN 201280075231 A CN201280075231 A CN 201280075231A CN 104519858 B CN104519858 B CN 104519858B
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- China
- Prior art keywords
- mouthwash
- acid
- amount
- combination
- phosphoric acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 239000002324 mouth wash Substances 0.000 title claims abstract description 65
- 229940051866 mouthwash Drugs 0.000 title claims abstract description 64
- 239000002253 acid Substances 0.000 title claims description 38
- 150000002118 epoxides Chemical class 0.000 title description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 53
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims abstract description 40
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 29
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims abstract description 25
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims abstract description 20
- 229920000642 polymer Polymers 0.000 claims abstract description 12
- 208000006558 Dental Calculus Diseases 0.000 claims abstract description 11
- 229920001577 copolymer Polymers 0.000 claims abstract description 11
- 229940081974 saccharin Drugs 0.000 claims abstract description 11
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims abstract description 11
- 235000019204 saccharin Nutrition 0.000 claims abstract description 11
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 claims abstract description 11
- 235000011180 diphosphates Nutrition 0.000 claims abstract description 10
- 230000002087 whitening effect Effects 0.000 claims abstract description 10
- 238000005282 brightening Methods 0.000 claims abstract description 9
- 239000004376 Sucralose Substances 0.000 claims abstract description 8
- 235000019408 sucralose Nutrition 0.000 claims abstract description 8
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims abstract description 8
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 claims abstract description 7
- 206010044029 Tooth deposit Diseases 0.000 claims abstract description 5
- -1 polyethylene Polymers 0.000 claims description 19
- 229910052783 alkali metal Inorganic materials 0.000 claims description 10
- 150000001340 alkali metals Chemical class 0.000 claims description 10
- 150000002978 peroxides Chemical group 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 229920002432 poly(vinyl methyl ether) polymer Polymers 0.000 claims description 5
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 claims description 4
- 150000002148 esters Chemical class 0.000 claims description 4
- 239000001257 hydrogen Substances 0.000 claims description 4
- 229910052739 hydrogen Inorganic materials 0.000 claims description 4
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 4
- 229960003500 triclosan Drugs 0.000 claims description 4
- 230000000845 anti-microbial effect Effects 0.000 claims description 3
- 230000002421 anti-septic effect Effects 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 2
- 239000002585 base Substances 0.000 claims description 2
- 229940041616 menthol Drugs 0.000 claims description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- DCAYPVUWAIABOU-UHFFFAOYSA-N hexadecane Chemical compound CCCCCCCCCCCCCCCC DCAYPVUWAIABOU-UHFFFAOYSA-N 0.000 claims 2
- 239000004698 Polyethylene Substances 0.000 claims 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- AOJFQRQNPXYVLM-UHFFFAOYSA-N pyridin-1-ium;chloride Chemical compound [Cl-].C1=CC=[NH+]C=C1 AOJFQRQNPXYVLM-UHFFFAOYSA-N 0.000 claims 1
- 239000000203 mixture Substances 0.000 abstract description 35
- 239000003513 alkali Substances 0.000 abstract description 11
- 238000002360 preparation method Methods 0.000 abstract description 10
- 238000009472 formulation Methods 0.000 abstract description 7
- 230000002378 acidificating effect Effects 0.000 abstract description 6
- 230000003405 preventing effect Effects 0.000 abstract description 3
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 abstract description 2
- 150000003839 salts Chemical class 0.000 description 17
- 235000015165 citric acid Nutrition 0.000 description 14
- 239000011734 sodium Substances 0.000 description 14
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 13
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 13
- 229940091249 fluoride supplement Drugs 0.000 description 13
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 12
- 235000003599 food sweetener Nutrition 0.000 description 11
- 239000003765 sweetening agent Substances 0.000 description 11
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 10
- 229910052708 sodium Inorganic materials 0.000 description 10
- 235000015424 sodium Nutrition 0.000 description 10
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 10
- 239000000080 wetting agent Substances 0.000 description 10
- 235000013599 spices Nutrition 0.000 description 9
- RYCLIXPGLDDLTM-UHFFFAOYSA-J tetrapotassium;phosphonato phosphate Chemical compound [K+].[K+].[K+].[K+].[O-]P([O-])(=O)OP([O-])([O-])=O RYCLIXPGLDDLTM-UHFFFAOYSA-J 0.000 description 9
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 8
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 7
- 239000003921 oil Substances 0.000 description 7
- 235000019198 oils Nutrition 0.000 description 7
- 239000011591 potassium Substances 0.000 description 7
- 229910052700 potassium Inorganic materials 0.000 description 7
- 229960003975 potassium Drugs 0.000 description 7
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 6
- 239000000872 buffer Substances 0.000 description 6
- 235000011187 glycerol Nutrition 0.000 description 6
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 6
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 239000003755 preservative agent Substances 0.000 description 5
- 230000002335 preservative effect Effects 0.000 description 5
- 159000000000 sodium salts Chemical class 0.000 description 5
- 150000005846 sugar alcohols Chemical class 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 4
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 4
- XPPKVPWEQAFLFU-UHFFFAOYSA-N diphosphoric acid Chemical compound OP(O)(=O)OP(O)(O)=O XPPKVPWEQAFLFU-UHFFFAOYSA-N 0.000 description 4
- 239000000796 flavoring agent Substances 0.000 description 4
- 235000019634 flavors Nutrition 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- UPBDXRPQPOWRKR-UHFFFAOYSA-N furan-2,5-dione;methoxyethene Chemical compound COC=C.O=C1OC(=O)C=C1 UPBDXRPQPOWRKR-UHFFFAOYSA-N 0.000 description 4
- TVHALOSDPLTTSR-UHFFFAOYSA-H hexasodium;[oxido-[oxido(phosphonatooxy)phosphoryl]oxyphosphoryl] phosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O TVHALOSDPLTTSR-UHFFFAOYSA-H 0.000 description 4
- WQYVRQLZKVEZGA-UHFFFAOYSA-N hypochlorite Chemical compound Cl[O-] WQYVRQLZKVEZGA-UHFFFAOYSA-N 0.000 description 4
- 229910052749 magnesium Inorganic materials 0.000 description 4
- 239000011777 magnesium Substances 0.000 description 4
- 239000000178 monomer Substances 0.000 description 4
- 229910052757 nitrogen Inorganic materials 0.000 description 4
- NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 description 4
- 210000003296 saliva Anatomy 0.000 description 4
- 239000011775 sodium fluoride Substances 0.000 description 4
- 235000013024 sodium fluoride Nutrition 0.000 description 4
- 229960000414 sodium fluoride Drugs 0.000 description 4
- 235000019832 sodium triphosphate Nutrition 0.000 description 4
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- 244000246386 Mentha pulegium Species 0.000 description 3
- 235000016257 Mentha pulegium Nutrition 0.000 description 3
- 235000004357 Mentha x piperita Nutrition 0.000 description 3
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 3
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 3
- 241000220324 Pyrus Species 0.000 description 3
- 229910001413 alkali metal ion Inorganic materials 0.000 description 3
- 229910001420 alkaline earth metal ion Inorganic materials 0.000 description 3
- 235000001014 amino acid Nutrition 0.000 description 3
- 229940024606 amino acid Drugs 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 239000003963 antioxidant agent Substances 0.000 description 3
- 235000006708 antioxidants Nutrition 0.000 description 3
- 235000010323 ascorbic acid Nutrition 0.000 description 3
- 229960005070 ascorbic acid Drugs 0.000 description 3
- 239000011668 ascorbic acid Substances 0.000 description 3
- 229910052791 calcium Inorganic materials 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- 229960005069 calcium Drugs 0.000 description 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 3
- 235000001050 hortel pimenta Nutrition 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 210000000214 mouth Anatomy 0.000 description 3
- 235000021017 pears Nutrition 0.000 description 3
- 239000002304 perfume Substances 0.000 description 3
- 239000011574 phosphorus Substances 0.000 description 3
- 229910052698 phosphorus Inorganic materials 0.000 description 3
- 230000035479 physiological effects, processes and functions Effects 0.000 description 3
- 229940048084 pyrophosphate Drugs 0.000 description 3
- 229940085605 saccharin sodium Drugs 0.000 description 3
- 239000001488 sodium phosphate Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 3
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- ZIRURAJAJIQZFG-UHFFFAOYSA-N 1-aminopropane-1-sulfonic acid Chemical compound CCC(N)S(O)(=O)=O ZIRURAJAJIQZFG-UHFFFAOYSA-N 0.000 description 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- MPPQGYCZBNURDG-UHFFFAOYSA-N 2-propionyl-6-dimethylaminonaphthalene Chemical compound C1=C(N(C)C)C=CC2=CC(C(=O)CC)=CC=C21 MPPQGYCZBNURDG-UHFFFAOYSA-N 0.000 description 2
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 2
- DDFHBQSCUXNBSA-UHFFFAOYSA-N 5-(5-carboxythiophen-2-yl)thiophene-2-carboxylic acid Chemical compound S1C(C(=O)O)=CC=C1C1=CC=C(C(O)=O)S1 DDFHBQSCUXNBSA-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 239000004475 Arginine Substances 0.000 description 2
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 2
- 239000004593 Epoxy Substances 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 description 2
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
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- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
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- LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical compound OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 150000003863 ammonium salts Chemical class 0.000 description 2
- 230000002882 anti-plaque Effects 0.000 description 2
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- 239000007864 aqueous solution Substances 0.000 description 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 2
- 235000009697 arginine Nutrition 0.000 description 2
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- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
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- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 description 2
- 238000004040 coloring Methods 0.000 description 2
- 239000002826 coolant Substances 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
- OSVXSBDYLRYLIG-UHFFFAOYSA-N dioxidochlorine(.) Chemical compound O=Cl=O OSVXSBDYLRYLIG-UHFFFAOYSA-N 0.000 description 2
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 2
- 239000000975 dye Substances 0.000 description 2
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 2
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- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 229910052744 lithium Inorganic materials 0.000 description 2
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- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 2
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- ZVVSSOQAYNYNPP-UHFFFAOYSA-N olaflur Chemical compound F.F.CCCCCCCCCCCCCCCCCCN(CCO)CCCN(CCO)CCO ZVVSSOQAYNYNPP-UHFFFAOYSA-N 0.000 description 2
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 2
- 150000004965 peroxy acids Chemical class 0.000 description 2
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- 238000006116 polymerization reaction Methods 0.000 description 2
- 239000011698 potassium fluoride Substances 0.000 description 2
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- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 2
- XXQBEVHPUKOQEO-UHFFFAOYSA-N potassium superoxide Chemical compound [K+].[K+].[O-][O-] XXQBEVHPUKOQEO-UHFFFAOYSA-N 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 229940083542 sodium Drugs 0.000 description 2
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 2
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 2
- 239000004334 sorbic acid Substances 0.000 description 2
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- 229940075582 sorbic acid Drugs 0.000 description 2
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical group F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 2
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- 235000012976 tarts Nutrition 0.000 description 2
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Abstract
本发明提供具有改进的味道以及良好的增白效力的漱口水制剂，所述制剂包含增白剂(例如过氧化氢)，连同第一酸(例如柠檬酸)和第二酸(例如磷酸)的组合。在其它实施方案中，所述漱口水可包含三氯蔗糖和糖精组合、酸性聚合物、一种或多种防牙结石剂(例如碱性焦磷酸盐)、马来酸酐和甲基乙烯基醚的共聚物和其它成分。
Description
背景
增白剂例如过氧化氢(H2O2)在漱口水中提供增白益处，但是基于过氧化物的漱口水通常伴随苦的异味。在漱口水中常用作增甜剂的糖精可能具有强的苦的余味，在包含H2O2的制剂中特别显著。此外，H2O2在高pH下尤其易于降解，并且为了使过氧化物降解最小化，具有H2O2的漱口水配方通常在低于pH 5.5下配制，通常通过加入酸来调节pH，这可得到不令人愉悦的酸味。
需要提供增白益处但也可口并且具有愉悦的味道的漱口水。
概述
本发明提供具有改进的味道以及良好的增白效力的漱口水制剂，其包含有效量的增白剂(例如过氧化氢)连同第一酸(例如柠檬酸)和第二酸(例如磷酸)的组合。例如，磷酸降低漱口水制剂的pH，柠檬酸用于在pH 4-5.5下提供强的缓冲能力。pKa为2.1、7.2和12.4的磷酸不是用于期望的pH的良好缓冲剂，而pKa为4.74的柠檬酸对于期望的pH提供更好的缓冲剂。相对于磷酸，柠檬酸具有较强的酸性气味，并且与单独的两种酸中的任一种相比，两种酸的组合在最终的制剂中提供更加可接受的酸性味道。在另一实施方案中，本发明提供使用三氯蔗糖和糖精组合来提供甜味，与具有单独的糖精的制剂(其证明具有强的苦的余味)相比，具有最小化的苦的余味。在另一实施方案中，漱口水可包含酸性聚合物，例如选自聚羧酸酯聚合物和聚乙烯基甲基醚/马来酸酐(PVME/MA)共聚物的聚合物，发现其进一步改进可口性以及漱口水的粘度，并且增强过氧化物的稳定性，漱口水还包含一种或多种防牙结石剂，例如，碱性焦磷酸盐，并且漱口水可含有香料/冷却剂，例如，其包含薄荷醇和水杨酸甲酯的组合。
由下文提供的详细说明，本发明的适用性的其它领域将变得显而易见。应理解的是，详细说明和具体实施例虽然指示本发明的优选的实施方案，但旨在仅为说明目的，并且不旨在限制本发明的范围。
详述
以下优选实施方案的描述仅为举例说明性质，并且绝不旨在限制本发明、其应用或用途。
在一种实施方案中，本发明提供一种漱口水，其包含其量有效增白牙齿的增白剂，连同含有pKa为4-5的第一酸的缓冲系统。
该实施方案的一方面在于，增白组合物包含至少一种环氧化合物作为增白剂，任选连同一种或多种另外的增白剂，例如二氧化氯、亚氯酸盐和次氯酸盐(例如，碱金属和碱土金属例如锂、钾、钠、镁、钙和钡的亚氯酸盐和次氯酸盐)。合适的环氧化合物包括过氧化氢、碱金属和碱土金属的过氧化物、有机环氧化合物和过氧酸及其盐。递送过羟基(OOH<->)离子的任何口服可接受的化合物是可用的。环氧化合物可任选以聚合物-过氧化物复合物形式存在，例如聚乙烯基吡咯烷酮-过氧化氢复合物。
碱金属和碱土金属的过氧化物包括过氧化锂、过氧化钾、过氧化钠、过氧化镁、过氧化钙和过氧化钡。
有机环氧化合物包括，例如，尿素过氧化物(也称为脲过氧化氢)、甘油基过氧化氢、烷基过氧化氢、二烷基过氧化物、烷基过氧酸、环氧酯、二酰基过氧化物、苯甲酰基过氧化物、单过氧邻苯二甲酸酯等。
过氧酸和它们的盐包括有机过氧酸例如烷基过氧酸和单过氧邻苯二甲酸酯，以及无机过氧酸盐，包括碱金属和碱土金属(例如锂、钾、钠、镁、钙和钡)的过硫酸盐、二过硫酸盐、过碳酸盐、过磷酸盐、过硼酸盐和过硅酸盐。另一种可用的环氧化合物为过氧水合焦磷酸钠。
该实施方案的一方面在于，第一酸为选自乙酸(pKa=4.76)、抗坏血酸(pKa=4.10)、苯甲酸(pKa=4.2)、柠檬酸(pKa=4.74)、对甲氧基苯甲酸(pKa=4.47)和丙酸(pKa=4.87)的酸，而第二酸选自氯酸、盐酸、硝酸、磷酸、硫酸和亚硫酸。在该实施方案另一方面，第一酸为柠檬酸，第二酸为磷酸。
该实施方案的另一方面在于，第二酸具有1.5-2.5的第一pKa和6.5-7.5的第二pKa，例如，磷酸(pKa1=2.1；pKa2=7.2)或亚硫酸(pKa1=1.8；pKa2=6.9)。
在一种实施方案中，本发明提供一种漱口水，其包含其量有效增白牙齿的过氧化氢，连同其量足以提供3-6的pH的柠檬酸和磷酸的组合，在一个实施方案中，pH为4-5.5。例如，本发明提供
1.1. 漱口水1，其中所述过氧化氢以0.01-5%的量，例如，1-3%的量，例如，约2%存在。
1.2. 任一种前述漱口水，其中所述磷酸和柠檬酸以1:1-10:1的比率存在。
1.3. 任一种前述漱口水，其中所述磷酸的量为0.01-1.5%，例如，0.5-1%，例如，约0.7%。
1.4. 任一种前述漱口水，其中所述柠檬酸的量为0.01-0.5%，例如，0.1-0.3%，例如，约2%。
1.5. 任一种前述漱口水，其还包含酸性聚合物，例如，选自聚羧酸酯聚合物和聚乙烯基甲基醚/马来酸酐(PVME/MA)共聚物的聚合物。
1.6. 任一种前述漱口水，其还包含防牙结石-有效量的一种或多种焦磷酸盐，例如，选自二碱金属或四碱金属焦磷酸盐，例如，Na4P2O7 (焦磷酸四钠或TSPP)、K4P2O7 (焦磷酸四钾或TKPP)、Na2K2P2O7、Na2H2P2O7和K2H2P2O7和它们的组合，例如，总量为0.5-5%，例如，1-3%。
1.7. 任一种前述漱口水，其包含TSPP和TKPP的组合，例如，总量为1-3%，例如，以1:1-1:5的比率，例如在一种实施方案，包含约0.3-0.6%，例如，0.4-0.5%的TSPP和1.2-1.5%，例如，1.3-1.4%的TKPP。
1.8. 任一种前述漱口水，其包含一种或多种湿润剂，例如，选自甘油、丙二醇、山梨糖醇，和其中的两种或更多种的组合，例如，总量为1-40%。
1.9. 任一种前述漱口水，其包含非糖增甜剂和/或糖增甜剂，例如，增甜量的糖精和三氯蔗糖的组合，例如，选自1:1-20:1和10:1-15:1的比率，例如，约0.025%糖精钠和约0.002%三氯蔗糖。
1.10. 任一种前述漱口水，其包含一种或多种香料或冷却剂，例如，其包含薄荷醇和水杨酸甲酯的组合，例如，约0.5:1-1.5:1的比率，例如，总量为0.1-1%。
1.11. 任一种前述漱口水，其包含一种或多种表面活性剂，例如，一种或多种非离子表面活性剂，例如，其包含一种或多种泊洛沙姆和/或聚山梨酸酯，例如，聚山梨酸酯20。
1.12. 任一种前述漱口水，其包含抗微生物有效量的抗菌剂，例如，选自三氯生和十六烷基氯化吡啶鎓。
1.13. 任一种前述漱口水，其包含有效量的氟化物。
1.14. 任一种前述漱口水，其包含游离或口服可接受的盐形式的有效量的碱性氨基酸，例如，精氨酸。
1.15. 任一种前述漱口水，其为含水溶液。
1.16. 任一种前述漱口水，其包含一种或多种或所有以下量的以下成分：
。
漱口水的一种实施方案包含：
。
本发明的一些实施方案提供一种增白牙齿的方法，所述方法包括对有需要的受试者的口腔给予本文描述的任何漱口水，例如，漱口水1等等。在一些实施方案中，给予包括漂洗约15-约60秒。在一些实施方案中，给予包括漂洗约30秒。本发明还提供本文描述的漱口水，例如，漱口水1等等，用于增白牙齿的方法。
本发明还提供磷酸和柠檬酸的组合在制造包含过氧化氢的漱口水(例如，在制造本文描述的任何漱口水，例如，漱口水1等等)中的用途。
在一些实施方案中，存在氟化物源，以有效提供约90-约500 ppm的氟化物的量存在。在其它实施方案中，氟化物源以有效提供约225 ppm的氟化物的量存在。在一些实施方案中，氟化物源选自氟化亚锡、氟化钠、氟化钾、单氟磷酸钠、氟硅酸钠、氟硅酸铵、氟化胺(例如、N'-十八烷基三亚甲基二胺-N,N,N'-三(2-乙醇)-二氢氟化物)、氟化铵、氟化钛、六氟硫酸盐，和其中的两种或更多种的组合。在一些实施方案中，氟化物源选自氟化钠；单氟磷酸钠；和它们的组合。在其它实施方案中，氟化物源包含氟化钠。在一些实施方案中，氟化物源以组合物的约0.02%-约0.2%重量的量存在。在一些实施方案中，氟化物源以组合物的约0.03%-约0.08%重量的量存在。其它实施方案提供一种组合物，其中氟化物源以组合物的约0.05%重量的量存在。在一些实施方案中，氟化物源以组合物的0.5%重量的量存在。
在一些实施方案中，存在碱性氨基酸，例如，其包含游离或口服可接受的盐形式的L-精氨酸。在一些实施方案中，碱性氨基酸选自精氨酸游离碱、精氨酸盐酸盐、精氨酸磷酸盐、精氨酸碳酸氢盐和它们的组合。在一些实施方案中，游离或口服可接受的盐形式的碱性氨基酸的有效量占制剂的0.05-2%重量(当采用口服可接受的盐形式时，按游离碱当量重量测量)。
一些实施方案还包含缓冲剂。在一些实施方案中，缓冲剂为磷酸钠缓冲剂(例如，磷酸一钠和磷酸二钠)。
其它实施方案还包含湿润剂，例如，选自甘油、山梨糖醇、丙二醇和其中的两种或更多种的组合的多元醇。本文可用的湿润剂包括多元醇，例如甘油、山梨糖醇、木糖醇或低分子量PEG、亚烷基二醇例如聚乙二醇或丙二醇。在各种实施方案中，湿润剂可操作用于防止糊膏或凝胶组合物在暴露于空气中时硬化。在各种实施方案中，湿润剂还用作增甜剂。在一些实施方案中，湿润剂各自以约1-约40%重量的量存在。在一些实施方案中，湿润剂为山梨糖醇。在一些实施方案中，山梨糖醇以约5-约25%重量的浓度存在。在一些实施方案中，山梨糖醇以约5-约15%重量的浓度存在。在一些实施方案中，山梨糖醇以约7-10%重量的浓度存在。本文提及山梨糖醇调整为指材料干重，但是该材料通常以70%含水溶液市售可得。在一些实施方案中，总湿润剂浓度为约1-约60%重量。在一些实施方案中，湿润剂为甘油。在一些实施方案中，甘油以约5-约15%重量的浓度存在。在一些实施方案中，甘油以约7.5%重量的浓度存在。在一些实施方案中，湿润剂为丙二醇。在一些实施方案中，丙二醇以约5-约15%重量的浓度存在。在一些实施方案中，丙二醇以约7%重量的浓度存在。
其它实施方案还包含抗菌剂，例如，三氯生或十六烷基氯化吡啶鎓。在漱口水制剂中，这些剂的抗菌有效量为约0.01-0.1%，例如，约0.03%三氯生或约0.07%十六烷基氯化吡啶鎓.
酸性聚合物(例如聚丙烯酸酯凝胶)可按它们的游离酸或者部分或完全中和的水溶性碱金属(例如，钾和钠)或铵盐的形式提供。某些实施方案包括马来酸酐或酸与另一种可聚合的乙烯属不饱和单体的约1:4-约4:1共聚物，例如，分子量(M.W.)为约30,000-约1,000,000的甲基乙烯基醚(甲氧基乙烯)。这些共聚物例如作为Gantrez AN 139(M.W. 500,000)、AN 119 (M.W. 250,000)和S-97药物级(M.W. 70,000)可得自GAF ChemicalsCorporation。其它可操作的聚合物包括那些例如马来酸酐与丙烯酸乙酯、甲基丙烯酸羟乙酯、N-乙烯基-2-吡咯烷酮或乙烯的1:1共聚物，后者例如作为Monsanto EMA No. 1103、M.W. 10,000和EMA Grade 61得到，以及丙烯酸与甲基丙烯酸甲酯或甲基丙烯酸羟乙酯、丙烯酸甲酯或丙烯酸乙酯、异丁基乙烯基醚或N-乙烯基-2-吡咯烷酮的1:1共聚物。通常合适的为含有活性碳-碳烯属双键和至少一个羧基的聚合的烯属或乙烯属不饱和羧酸，也就是，含有烯属双键的酸，其容易在聚合中起作用，因为其在相对于羧基的α-β位置或作为末端亚甲基的一部分存在于单体分子中。这样的酸的示例有丙烯酸、甲基丙烯酸、乙基丙烯酸、α-氯丙烯酸、巴豆酸、β-丙烯酰氧基丙酸、山梨酸、α-氯山梨酸、肉桂酸、β-苯乙烯基丙烯酸、粘康酸、衣康酸、柠康酸、中康酸、戊烯二酸、乌头酸、α-苯基丙烯酸、2-苄基丙烯酸、2-环己基丙烯酸、当归酸、伞形酸、富马酸、马来酸和它们的酸酐。可与这样的羧基单体共聚的其它不同的烯属单体包括乙酸乙烯酯、氯乙烯、马来酸二甲酯等。共聚物可含有足够的羧基盐基团用于水溶性。酸性聚合物或共聚物可以0.1-5%的水平存在，例如，1-2%的PVME/MA。
本发明的组合物旨在局部用于口腔，因此用于本发明的任何盐应为口服可接受的，也就是，以提供的量和浓度安全用于口腔局部应用。合适的盐包括本领域已知为药学上可接受的盐的盐，通常认为以提供的量和浓度用于该目的是口服可接受的。口服可接受的盐包括衍生自药学上可接受的无机或有机酸或碱的那些，例如由形成生理学可接受的阴离子的酸形成的酸加成盐，例如，盐酸盐，以及由形成生理学可接受的阳离子的碱形成的碱加成盐，例如衍生自碱金属(例如钾和钠)或碱土金属(例如钙和镁)的那些。使用本领域已知的标准程序可得到生理学可接受的盐，例如，通过使足够碱性的化合物(例如胺)与提供生理学可接受的阴离子的合适的酸反应。
在一些实施方案中，组合物还包含一种或多种选自以下的组分：氟离子源；牙垢控制剂；缓冲剂；研磨剂；和其中的两种或更多种的组合。在一些实施方案中，一种或多种组分中的至少一种为选自以下的氟离子源：氟化亚锡、氟化钠、氟化钾、单氟磷酸钠、氟硅酸钠、氟硅酸铵、氟化胺、氟化铵，和其中的两种或更多种的组合。
虽然过氧化物通常有效控制微生物，但在一些实施方案中，存在另外的防腐剂。在一些实施方案中，防腐剂选自对羟基苯甲酸酯、山梨酸钾、苄醇、苯氧基乙醇、聚氨基丙基双胍、辛酸、苯甲酸钠和十六烷基氯化吡啶鎓。在一些实施方案中，防腐剂以约0.0001-约1%重量的浓度存在。在一些实施方案中，防腐剂以约0.01-约1%重量的浓度存在。在一些实施方案中，防腐剂以约0.5%重量的浓度存在。
着色剂例如染料可为目前按the Food Drug & Cosmetic Act认定的用于食品和摄取药物的食品颜色添加剂，包括染料例如FD&C Red No. 3 (四碘荧光素的钠盐)、FoodRed 17(6-羟基-5-{(2-甲氧基-5-甲基-4-磺基苯基)偶氮}-2-萘磺酸的二钠盐)、FoodYellow 13(quinophtalone或2-(2-喹啉基)茚满二酮的单和二磺酸的混合物的钠盐)、FD&CYellow No. 5 (4-对磺基苯基偶氮-1-对磺基苯基-5-羟基吡唑-3-甲酸的钠盐)、FD&CYellow No. 6 (对磺基苯基偶氮-B-萘酚-6-单磺酸盐的钠盐)、FD&C Green No. 3 (4-{[4-(N-乙基-对磺基苄基氨基)-苯基]-(4-羟基-2-硫鎓苯基)-亚甲基}-[1-(N-乙基-N-对磺基苄基)-δ-3,5-环己二烯亚胺]的二钠盐)、FD&C Blue No. 1 (二苄基二乙基-二氨基-三苯基甲醇三磺酸无水石膏的二钠盐)、FD&C Blue No. 2 (靛蓝的二磺酸的钠盐)和它们的各种比例的混合物。通常，着色剂(如果包括)以非常少的量存在。
香料剂为已知的，例如天然和人造香料。这些香料可选自合成的香料油和香料芳族化合物和/或油、油树脂和衍生自植物、叶、花、果实等的提取物，和它们的组合。代表性香料油包括：绿薄荷油、肉桂油、胡椒薄荷油、丁香油、月桂油、百里香油、杉木叶油、内豆蔻的油、鼠尾草的油和苦杏仁的油。这些香料剂可单个使用或混合使用。常用的香料包括薄荷例如胡椒薄荷、人造香草、肉桂衍生物和各种水果香料，无论单个使用或混合使用。通常，可使用任何香料或食品添加剂，例如在Chemicals Used in Food Processing(用于食品加工的化学品)，出版物1274，the National Academy of Sciences，第63-258页中描述的那些。通常，香料(如果包括)以0.01-1%重量存在。在一些实施方案中，香料可以约0.2%重量存在。
增甜剂包括天然和人造增甜剂二者。合适的增甜剂包括但不限于水溶性糖增甜剂，例如单糖、二糖和多糖，例如木糖、核糖、葡萄糖(右旋糖)、甘露糖、半乳糖、果糖(左旋糖)、蔗糖(糖)、麦芽糖，以及水溶性人造非糖增甜剂，例如可溶性糖精盐，即，糖精钠或糖精钙，基于环己基氨基磺酸盐二肽的增甜剂，例如L-天冬氨酸衍生的增甜剂，例如L-天冬氨酰基-L-苯丙氨酸甲酯(阿司帕坦)。通常，用于提供特定组合物期望的甜味水平的增甜剂的有效量根据所选的增甜剂而改变。该量通常为组合物的约0.001%-约5%重量。在一些实施方案中，增甜剂为以组合物的0.001-0.003%存在的三氯蔗糖和以约0.01-0.03%重量存在的糖精钠的组合。
可提供任选的口气清新剂。可使用任何口服可接受的口气清新剂，包括但不限于锌盐例如葡糖酸锌、柠檬酸锌和亚氯酸锌、α-紫罗兰酮和它们的混合物。一种或多种口气清新剂任选以口气清新有效总量存在。
任选，组合物可包括牙垢控制(防牙结石)剂。本文可用的那些牙垢控制剂包括磷酸盐和聚磷酸盐(例如焦磷酸盐)、聚氨基丙磺酸(AMPS)、聚烯烃磺酸盐、聚烯烃磷酸盐、二膦酸盐例如氮杂环烷烃-2,2-二膦酸盐(例如，氮杂环庚烷-2,2-二膦酸)、N-甲基氮杂环戊烷-2,3-二膦酸、乙烷-1-羟基-1,1-二膦酸(EHDP)和乙烷-1-氨基-1,1-二膦酸盐、膦酰基烷羧酸和任何这些剂的盐，例如它们的碱金属和铵盐。可用的无机磷酸盐和聚磷酸盐包括一元、二元和三元的钠磷酸盐、三聚磷酸钠、四聚磷酸钠、焦磷酸单钠、二钠、三钠和四钠、三偏磷酸钠、六偏磷酸钠和它们的混合物，其中钠可任选被钾或铵代替。
在一个特定的实施方案中，漱口水包含焦磷酸盐，其具有防牙结石效力，可用于本发明的实践，包括水溶性盐，例如二碱金属或四碱金属焦磷酸盐，例如Na4P2O7 (TSPP)、K4P2O7 (TKPP)、Na2K2P2O7、Na2H2P2O7和K2H2P2O7。聚磷酸盐包括水溶性碱金属三聚磷酸盐，例如三聚磷酸钠和三聚磷酸钾。焦磷酸盐以约0.5-约2%重量，优选约1.5-约2%重量的浓度掺入到本发明的洁齿剂组合物中，聚磷酸盐以约1-约7%重量的浓度掺入到本发明的洁齿剂组合物中。在一些实施方案中，牙垢控制剂以约0.01-10%重量的浓度存在。在一些实施方案中，牙垢控制剂以约1%重量的浓度存在。在一些实施方案中，牙垢控制剂也用作缓冲剂。例如，在磷酸盐缓冲系统中，磷酸一钠以约0.01-约5%重量的浓度存在，磷酸二钠以约0.01-约5%重量的浓度存在，精确的比率取决于制剂中的其它赋形剂和期望的pH。
抗氧化剂为另一类任选的添加剂。可使用任何口服可接受的抗氧化剂，包括丁基化的羟基苯甲醚(BHA)、丁基化的羟基甲苯(BHT)、维生素A、类胡萝卜素、维生素E、类黄酮化合物、聚苯酚、抗坏血酸、草本抗氧化剂、叶绿素、褪黑素，和它们的混合物。
另外，可包括可用于例如改善干口症的任选的唾液刺激剂。可使用任何口服可接受的唾液刺激剂，包括但不限于食品酸，例如柠檬酸、乳酸、苹果酸、琥珀酸、抗坏血酸、己二酸、富马酸和酒石酸，和它们的混合物。一种或多种唾液刺激剂任选以唾液刺激有效总量存在。
任选，可包括抗斑(例如，斑分裂)剂。可使用任何口服可接受的抗斑剂，包括但不限于亚锡、铜、镁和锶盐、聚二甲硅氧烷共聚多元醇例如十六烷基聚二甲硅氧烷共聚多元醇、木瓜蛋白酶、葡糖淀粉酶、葡萄糖氧化酶、尿素、乳酸钙、甘油基磷酸钙、聚丙烯酸锶和它们的混合物。
任选的脱敏剂包括柠檬酸钾、氯化钾、酒石酸钾、碳酸氢钾、草酸钾、硝酸钾、锶盐，和它们的混合物。在一些实施方案中，可使用局部或全身止痛药，例如阿司匹林、可待因、乙酰氨基酚、水杨酸钠或三乙醇胺水杨酸盐。
从始至终使用的范围用作描述在该范围内的每个和所有值的缩写。可选择在该范围内的任何值作为范围的端点。此外，本文引用的所有参考文献通过引用而全文结合到本文中。在本公开的定义与引用的参考文献冲突的情况下，以本公开为准。
除非另外指定，否则本文和在说明书的其它地方表述的所有百分数和量应理解为指重量百分数。给出的量基于材料的活性重量。
实施例
实施例1-漱口水制剂
包含酸与过氧化氢的各种组合的漱口水制剂描述于表1 (以下)
表1
。
实施例2-专家感觉评定
由感觉专家评价组合物1-4的制剂，以1-5的数值范围各自评价酸度和苦的余味，其中1为根本不酸/苦，而5为极酸/苦。对于任一个参数4或5的分数或者两个参数3的分数认为是不可接受的。
表2
| 1 | 2% H2O2/TSPP/TKPP/磷酸/糖精 | 酸(3)/苦的余味(3) |
| 2 | 2% H2O2/TSPP/TKPP/柠檬酸/糖精 | 酸(4)/苦的余味(3) |
| 3 | 2% H2O2/TSPP/TKPP/柠檬酸/磷酸/糖精 | 酸(2)/苦的余味(3) |
| 4 | 2% H2O2/TSPP/TKPP/磷酸/柠檬酸/糖精/三氯蔗糖 | 酸(2)/苦的余味(2) |
基于该研究，发现组合物1和2是不可接受的。优选组合物4，其较少酸味并且具有较少苦的余味。
实施例3-消费者测试
通过加入1.5% Gantrez®(聚甲基乙烯基醚和马来酸酐的共聚物)，还对组合物4进行改性，并且在消费者测试方案中测试具有和不具有Gantrez®的制剂。共120名常规的漱口水使用者参与漱口水的单一家用测试。指示每一名参与者使用产品5天。在使用阶段结束时，使用1-9的数值范围，让参与者评定漱口水的总体喜好，其中1为“极不喜欢”，9为“极喜欢”。报道给出7-9的总体喜好分数的参与者总百分数。测试配方和结果在以下表3中列举。
表3
| 组合物4 | 组合物5 | |
| 水 | 73.95 | 72.45 |
| TSPP | 0.45 | 0.45 |
| TKPP | 1.35 | 1.35 |
| Gantrez® | 0 | 1.51 |
| 糖精钠 | 0.025 | 0.025 |
| 三氯蔗糖 | 0.002 | 0.002 |
| 磷酸 | 0.8 | 0.8 |
| 柠檬酸 | 0.2 | 0.2 |
| 湿润剂 | 20 | 20 |
| 表面活性剂 | 1 | 1 |
| 过氧化氢 | 2 | 2 |
| 香料 | 0.22 | 0.22 |
| 消费者测试结果(总体喜好) | 23.8% | 29.5% |
发现组合物5更可口并且被消费者优选，并且显示总体喜好24%提高(29.5-23.8)/(23.8)×100%)。
由此已详细描述了本发明的各种实施方案，应理解的是，以上段落限定的本发明不局限于在以上描述中陈述的具体细节，在不偏离本发明的精神或范围下，许多明显的变化是可能的。
Claims (10)
1.一种漱口水，所述漱口水包含其量有效增白牙齿的增白剂，其中所述增白剂为过氧化氢，任选连同一种或多种另外的增白剂，以及第一酸与第二酸的组合，其中所述第一酸包含柠檬酸，而所述第二酸包含磷酸，其中所述柠檬酸和磷酸的量足以提供3-6的pH，且其中所述漱口水包含60％-80％的量的水，其中所述柠檬酸和磷酸以1∶1-1∶10的比率存在，所述磷酸的量为0.01-1.5％，以及所述柠檬酸的量为0.01-0.5％。
2.权利要求1的漱口水，其中所述过氧化氢以0.01-5％的量存在。
3.前述权利要求中任一项的漱口水，所述漱口水还包含选自聚羧酸酯聚合物和聚乙烯基甲基醚/马来酸酐(PVME/MA)共聚物的聚合物。
4.权利要求1或2的漱口水，所述漱口水还包含防牙结石-有效量的一种或多种选自二碱金属或四碱金属焦磷酸盐的焦磷酸盐。
5.权利要求1或2的漱口水，所述漱口水还包含增甜量的糖精和三氯蔗糖的组合。
6.权利要求1或2的漱口水，所述漱口水还包含薄荷醇和水杨酸甲酯的组合。
7.权利要求1或2的漱口水，所述漱口水还包含抗微生物有效量的选自三氯生和十六烷基氯化吡啶鎓的抗菌剂。
8.权利要求1或2的漱口水，所述漱口水包含一种或多种或所有以下量的以下成分：
。
9.权利要求1或2的漱口水，所述漱口水包含：
。
10.权利要求1-9中任一项的漱口水在制造用于增白牙齿的药物中的用途。
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| MX2019002921A (es) | 2016-09-28 | 2019-07-18 | Colgate Palmolive Co | Composiciones para el cuidado bucal y sistema para dispensar las mismas. |
| CN110996888A (zh) * | 2017-08-07 | 2020-04-10 | 高露洁-棕榄公司 | 包含环状酸酐的口腔护理组合物 |
| US11110047B2 (en) * | 2017-08-07 | 2021-09-07 | Colgate-Palmolive Company | Oral care compositions including cyclic anhydrides |
| US20190083366A1 (en) * | 2017-09-19 | 2019-03-21 | Marlinspike Group, Inc. | Mouthwash granules for an aqueous solution |
| KR102430222B1 (ko) * | 2017-11-28 | 2022-08-05 | 주식회사 엘지생활건강 | 치아 미백용 조성물 |
| CN108096047A (zh) * | 2018-02-10 | 2018-06-01 | 广州市九科精细化工有限公司 | 度米芬木糖醇复合酸性漱口水及其制备方法 |
| CN108014024A (zh) * | 2018-02-10 | 2018-05-11 | 广州市九科精细化工有限公司 | 一种深层去除烟垢茶垢的漱口水及其制备方法 |
| CN108042383A (zh) * | 2018-02-10 | 2018-05-18 | 广州市九科精细化工有限公司 | 一种消炎、抑菌的度米芬漱口水及其制备方法 |
| CN108066167A (zh) * | 2018-02-10 | 2018-05-25 | 广州市九科精细化工有限公司 | 一种可视化抑菌美白酸性漱口水及其制备方法 |
| KR101956578B1 (ko) | 2018-05-09 | 2019-03-11 | 주식회사 하이센스바이오 | 상아질 지각과민증 완화를 위한 구강 청결용 조성물 |
| KR101956579B1 (ko) | 2018-05-09 | 2019-03-11 | 주식회사 하이센스바이오 | 상아질 지각과민증 완화를 위한 치약 조성물 |
| BR102019021197A2 (pt) | 2019-10-09 | 2021-04-20 | Luiz Jabbur Junior | agente de gargarejo compreendendo um conjunto de substâncias acopladas, método de uso e controle do caseum |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6447757B1 (en) * | 2000-11-08 | 2002-09-10 | Scientific Pharmaceuticals, Inc. | Teeth whitening composition with increased bleaching efficiency and storage stability |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060171907A1 (en) * | 1996-11-21 | 2006-08-03 | The Procter & Gamble Company | Oral care compositions providing enhanced whitening and stain prevention |
| US6207139B1 (en) * | 1999-04-16 | 2001-03-27 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Anti-tartar dental product and related method |
| US20020061282A1 (en) * | 2000-10-11 | 2002-05-23 | Constantine Georgiades | Tooth whitening composition and method employing dicarboxylic acid whitening agent |
| ES2330933T3 (es) * | 2002-11-15 | 2009-12-17 | Virox Technologies Inc. | Desinfectante de peroxido de hidrogeno que contiene un acido y/o un alcohol. |
| JP2004210721A (ja) * | 2002-12-27 | 2004-07-29 | Kao Corp | 口腔用組成物及びチューインガム |
| US20080318834A1 (en) * | 2004-02-24 | 2008-12-25 | Campina B.V. | Antimicrobial Lactoferrin Compositions for Surfaces, Cavities, and Foodstuff |
| US7641892B2 (en) * | 2004-07-29 | 2010-01-05 | Cadburry Adams USA, LLC | Tooth whitening compositions and delivery systems therefor |
| US20060045855A1 (en) * | 2004-09-02 | 2006-03-02 | Sasson J A | Oral composition for reducing plaque and microbial infections and whitening teeth |
| US9198448B2 (en) * | 2005-02-07 | 2015-12-01 | Intercontinental Great Brands Llc | Stable tooth whitening gum with reactive ingredients |
| US20070116831A1 (en) | 2005-11-23 | 2007-05-24 | The Coca-Cola Company | Dental Composition with High-Potency Sweetener |
| US7803353B2 (en) | 2006-03-29 | 2010-09-28 | The Procter & Gamble Company | Oral care compositions having improved consumer aesthetics and taste |
| US20080025926A1 (en) * | 2006-07-24 | 2008-01-31 | Dr. Nick's White & Healthy, Llc | Oral care formulations with hydrogen peroxide and lycopene |
| US20080175801A1 (en) * | 2007-01-18 | 2008-07-24 | The Procter & Gamble Company | Stable peroxide containing personal care compositions |
| JP2008201732A (ja) * | 2007-02-21 | 2008-09-04 | Kao Corp | 歯の美白方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US6447757B1 (en) * | 2000-11-08 | 2002-09-10 | Scientific Pharmaceuticals, Inc. | Teeth whitening composition with increased bleaching efficiency and storage stability |
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| JP2015524466A (ja) | 2015-08-24 |
| AR092084A1 (es) | 2015-03-18 |
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| BR112015002969B1 (pt) | 2018-06-26 |
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| MX349988B (es) | 2017-08-22 |
| RU2639376C2 (ru) | 2017-12-21 |
| TWI472346B (zh) | 2015-02-11 |
| MX2015001787A (es) | 2015-05-07 |
| EP2882404A1 (en) | 2015-06-17 |
| US9161892B2 (en) | 2015-10-20 |
| KR20150040339A (ko) | 2015-04-14 |
| IN2015DN00307A (zh) | 2015-06-12 |
| CN104519858A (zh) | 2015-04-15 |
| WO2014025355A1 (en) | 2014-02-13 |
| RU2015107834A (ru) | 2016-09-27 |
| PH12015500195B1 (en) | 2015-04-06 |
| AU2012387171B2 (en) | 2015-05-07 |
| EP2882404B1 (en) | 2017-10-04 |
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