CN104510489B - Device for PET-CT-MR image fusion and fixation of experimental animal - Google Patents
Device for PET-CT-MR image fusion and fixation of experimental animal Download PDFInfo
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- CN104510489B CN104510489B CN201510014476.5A CN201510014476A CN104510489B CN 104510489 B CN104510489 B CN 104510489B CN 201510014476 A CN201510014476 A CN 201510014476A CN 104510489 B CN104510489 B CN 104510489B
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Abstract
The invention discloses a device for PET-CT-MR image fusion and fixation of an experimental animal. The device comprises a fixed frame, a support plate and three sets of positioning rods, wherein a plurality of positioning screws are arranged on the support plate, an elastic rope is arranged on one positioning screw, and fixing ropes and clamp nuts are arranged on the other positioning screws; the three sets of positioning rods have the same number (at least three) of positioning rods; one set of positioning rods is fixed on the fixed frame simultaneously, wherein at least two positioning rods are inclined relative to each other; the positioning rods in each set are filled with PET, CT and MR photographic developers respectively, the positioning rods can be changed to add positioning information to three different image data of the experimental animal, namely PET image data, CT image data and MR image data, and accurate fusion of any more than two scan images is realized by an external feature point extraction method. The device is simple and convenient to operate, can be used repeatedly, guarantees the safety of the animal and workers, meanwhile provides a basis for deep study on image fusion methods and provides more effective, accurate and visual aid for scientific research and clinic and translation thereof.
Description
Technical field
Fix for laboratory animal and laboratory animal image co-registration is in the auxiliary equipment of one, specifically the present invention relates to a kind of
It is related to a kind of small animal position emission tomography (PET), CT and MR image co-registration and fixing device, the fixation for laboratory animal and PET, CT and MR figure
As merging, the clinical conversion for zoopery and image fusion technology provides foundation.
Background technology
Laboratory animal, such as Mus, rabbit etc., it is widely used in various medical experiments and scientific research as experimental subject, be existing
For one of more common animal model in medical laboratory.But murine all can make resistance to any unconditioned stimulus, very
To unnecessary injury is caused to experimenter, laboratory animal is fixed particularly important therefore in experimentation.
In recent years, toy in-vivo imaging is widely used in the research of toy disease model, tumor generting machanism, tumor
In the experiments such as early stage imaging, on this basis, judge whether made animal model meets clinical needs, institute's transplantation tumor state is
The no experiment needs that meet just are particularly important.
With the continuous progress of modern medicine, radiology and computer technology, the development of Medical Imaging Technology is maked rapid progress,
Various emerged in an endless stream based on the medical image of different image-forming principles.Become as CT, the MR for image anatomy and for function
The PET of picture.These three imaging modes have each unique imaging advantage, if can be merged its gained image, can be
The early diagnosiss of disease and treatment, provide bigger help.Therefore, Medical image fusion has become the focus of modern medicine study,
But image co-registration mode is still immature, and human body can not be applied to be studied, more data can only be obtained by zoopery,
To find the image interfusion method of optimum.
However, but single function, its material mostly various metals various currently used for the fixing device species of laboratory animal
Product is it is difficult to compatible multiple imaging device, and does not fix recognition site it is impossible to realize experiment in laboratory animal or fixing device
The image co-registration of animal.
Content of the invention
For prior art, the present invention provides a kind of device for small animal position emission tomography (PET), CT and MR image co-registration and fixation,
The method is by making laboratory animal be fixed by special purpose device, and carries out different imaging mode scannings, and obtained two
Plant or three kinds of imaging inspection images can accurately repeat to identical aspect, so that two image co-registration are achieved, be
Research image co-registration methods provide foundation.
In order to solve above-mentioned technical problem, the present invention is used for laboratory animal PET, CT and MR image co-registration and fixing device
The technical scheme being achieved is：This fixing device includes fixed frame, gripper shoe and three sets of locating bars, described fixed frame by
The bracing frame at top and a plurality of supporting leg are constituted, and supporting leg is provided with support, and described gripper shoe load is on supporting；Described gripper shoe
It is provided with multiple Positioning screws, one of Positioning screw is fixed with elastic threads, respectively solid in remaining each Positioning screw
Surely there are static line and clamp nut；Described locating bar is made up of hollow pipe and plug, and often canned respectively in set locating bar have PET to show
As agent or CT developer or MR developer；Often the quantity of set locating bar is identical and at least three；On described fixed frame simultaneously
It is fixed with a set of locating bar；It is fixed at least two locating bars in a set of locating bar on fixed frame to be mutually inclined.
Compared with prior art, the invention has the beneficial effects as follows：
The assembling of fixing device of the present invention and easy and simple to handle, reusable, ensureing laboratory animal and staff
Safe while, be that the image co-registration of toy plurality of medical scanogram provides feasible location measure, be scientific research and
Its clinic conversion provides more effectively, accurately, intuitively help.
Using the image co-registration of fixing device of the present invention can be applicable to the research of toy disease model, tumor generting machanism,
In the experimentatioies such as tumor early stage imaging, on this basis, judge whether made animal model meets clinical needs, transplanted and swell
Whether warty state meets experiment needs.Meanwhile, be conducive to carrying out more zooperies and think that clinic finds the image of optimum and melts
Conjunction method provides foundation.There is very important using value.
Brief description
Fig. 1 is the overall structure diagram of fixing device of the present invention；
Fig. 2 is the exploded view of fixing device shown in body 1.
In figure：
1- gripper shoe 11- static line 12- Positioning screw 13- elastic threads
14- bolt 15- clamp nut 2- fixed frame 21- bracing frame
22- positioning through hole 23- supports 24- supporting leg 25- base
3- locating bar
Specific embodiment
With specific embodiment, technical solution of the present invention is described in further detail below in conjunction with the accompanying drawings.
As depicted in figs. 1 and 2, the present invention is used for laboratory animal PET, CT and MR image co-registration and fixing device, including
Fixed frame 2, gripper shoe 1 and three sets of locating bars 3, described fixed frame 2 is by the bracing frame 21 at top and a plurality of supporting leg 24 structure
Become, supporting leg 24 is provided with support 23, described gripper shoe 1 is carried on a shoulder pole and supported on 23, and the bottom of described supporting leg 24 is provided with base 25.
Described gripper shoe 1 is provided with multiple Positioning screws 12, and one of Positioning screw 12 is fixed with elastic threads 13,
Respectively it is fixed with static line 11 and clamp nut 15 in remaining each Positioning screw 12.
Described locating bar 3 is made up of hollow pipe and plug, and often canned respectively in set locating bar 3 have PET developer or CT to show
As agent or MR developer；Often the quantity of set locating bar 3 is identical and at least three；It is fixed with one on described fixed frame 2 simultaneously
Set locating bar 3, described fixed frame 2 is provided with positioning through hole 22, and described locating bar 3 is through positioning in positioning through hole 22.Fixing
In a set of locating bar 3 on fixed frame 2, at least two locating bars 3 are mutually inclined.
A plurality of locating bar 3 relative misalignment is arranged, the superposition of figure layer in being conducive to merging for successive image provides accurately
Positioning datum, because in image procossing, 3 points can determine that a plane, by least three locating bars 3 of oblique arrangement,
As selected four locating bars 3 it is provided that four points are to determine a plane so that every in PET or CT or MR gained image
Tomographic image all has each self-corresponding four points, based on a certain aspect on a kind of image check method gained image, according to
Four datum marks thereon, look for its corresponding aspect on other two kinds or a kind of reconstruction image of inspection method, and incite somebody to action the two
Merged, to realize being accurate to point-to-point image co-registration.
In the present invention, the selection principle of each construction material is：As long as PET, CT, MR imaging and not shadow can be applied simultaneously to
Ring the material of imaging effect.
Using the present invention, medical scanning is carried out to laboratory animal and the process of image co-registration is：
Step one, medical scanning is carried out to toy before, the process fixing toy with fixing device of the present invention is as follows：
Gripper shoe 1 was carried on a shoulder pole before fixed frame 2, first with static line 11, the extremity of toy is fixed on gripper shoe 1,
And static line 11 is wound in Positioning screw 12, then fixation will be tightened with clamp nut 15, then use one of Positioning screw
The tooth of the fixing toy of the elastic threads 13 on 12, thus toy is fixed in gripper shoe 1；Gripper shoe 1 is carried on a shoulder pole and is propping up
In support 23, gripper shoe 1 is inserted in the support 23 on fixed frame 2, keep its relative position to fix；Bracing frame 21 and supporting leg
24 are provided with location hole 22, the position relative dislocation of location hole 22, and can be inserted obliquely into wherein by locating bar 3, in locating bar 3
It is filled with the developer being respectively suitable for PET, CT or MR imaging, whole device is smoothly positioned over by scanning by base 25
Bed.
Step 2, the MR scanogram of whole body obtaining animal by the following method, PET scan image and CT scan image
In two or more scanograms, and no tandem：
2 A, acquisition MR scanogram：
The whole device fixing animal is smoothly positioned on MR examinating couch, has the four of paramagnetic contrast's agent by canned
Individual locating bar 3 is inserted in paired positioning through hole 22 on fixed frame 2 and supporting leg 24, carries out three-dimensional MR to region of interest and sweeps
Retouch, writing scan image information data；
2 B, acquisition PET scan image：
The whole support fixing animal is steadily positioned on PET examinating couch, locating bar is changed into and canned shows containing PET
Four locating bars of track agent, carry out PET scan, and writing scan image information data；
2-C, acquisition CT scan image：
The whole support fixing animal is steadily positioned on CT examination bed, locating bar is changed into canned has iodine preparation
Four locating bars of high density contrast agent, carry out CT scan, and writing scan image information data；
Step 3, extract locating bar from every width scanogram information data that step 2 obtains by surface extraction method
The labelling point being provided, using this labelling point as the datum mark of image co-registration；Image is carried out by Photoshop computer software
Integrate, reconstruction processing, if having ready conditions realization three-dimensional PET scan when, during image co-registration, can optionally PET, CT or MR
Scanogram reconstructs the image of required angle, and with the datum mark in this image as standard, rebuild another or two kinds sweep
Tracing picture, is merged PET, CT or MR reconstruction image of identical aspect two-by-two or three is merged simultaneously；When only feasible two dimension
During PET scan, during image co-registration, then with the datum mark in PET standard axle position as standard, rebuild CT and/or MR and check
Figure, finally by the PET scan image information fusion of identical aspect in CT and/or MR reconstruction image, thus realize in same width
The scanogram information of more than above two is shown in image.
Although above in conjunction with accompanying drawing, invention has been described, the invention is not limited in above-mentioned being embodied as
Mode, above-mentioned specific embodiment is only schematically, rather than restricted, and those of ordinary skill in the art is at this
Under the enlightenment of invention, without deviating from the spirit of the invention, many variations can also be made, these belong to the present invention's
Within protection.
Claims (3)
1. a kind of for laboratory animal PET, CT and MR image co-registration and fixing device it is characterised in that：
Including fixed frame (2), gripper shoe (1) and three sets of locating bars (3), described fixed frame (2) is by the bracing frame at top
(21) constitute with a plurality of supporting leg (24), supporting leg (24) is provided with support (23), described gripper shoe (1) load is supporting (23)
On；
Described gripper shoe (1) is provided with multiple Positioning screws (12), and one of Positioning screw (12) is fixed with elastic threads
(13), remaining each Positioning screw (12) is respectively fixed with static line (11) and clamp nut (15)；
Described locating bar (3) is made up of hollow pipe and plug, and often canned respectively in set locating bar (3) have PET developer or CT to show
As agent or MR developer；Often the quantity of set locating bar (3) is identical and at least three；Fix on described fixed frame (2) simultaneously
There is a set of locating bar (3)；It is mutual for being fixed at least two locating bars (3) in a set of locating bar (3) on fixed frame (2)
Tilt.
2. be used for laboratory animal PET, CT and MR image co-registration and fixing device according to claim 1 it is characterised in that
Described fixed frame (2) is provided with positioning through hole (22), and described locating bar (3) is through positioning in positioning through hole (22).
3. be used for laboratory animal PET, CT and MR image co-registration and fixing device according to claim 1 it is characterised in that
The bottom of described supporting leg (24) is provided with base (25).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510014476.5A CN104510489B (en) | 2015-01-12 | 2015-01-12 | Device for PET-CT-MR image fusion and fixation of experimental animal |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510014476.5A CN104510489B (en) | 2015-01-12 | 2015-01-12 | Device for PET-CT-MR image fusion and fixation of experimental animal |
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| Publication Number | Publication Date |
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| CN104510489A CN104510489A (en) | 2015-04-15 |
| CN104510489B true CN104510489B (en) | 2017-02-08 |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN116115245A (en) * | 2023-02-14 | 2023-05-16 | 重庆全景红岭医学影像诊断中心有限公司 | Stereotactic frame for fusion of abdominal basin PET, CT and MR images |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN201131816Y (en) * | 2007-12-04 | 2008-10-15 | 中日友好医院 | Multifunctional test operation table |
| KR101100390B1 (en) * | 2008-12-22 | 2011-12-30 | 울산대학교 산학협력단 | Apparatus fixing the position and location of mouse for imaging acquisition with multiple modalities |
| WO2012076660A1 (en) * | 2010-12-08 | 2012-06-14 | Universiteit Antwerpen | Animal positioning for in-vivo imaging |
| CN203234754U (en) * | 2013-04-17 | 2013-10-16 | 中国人民解放军第三军医大学第二附属医院 | Animal fixing bed used for imaging examination |
| CN103735252B (en) * | 2014-01-14 | 2016-01-20 | 中国科学院自动化研究所 | A kind of Optical multi-mode state imaging system and method |
| CN204394546U (en) * | 2015-01-12 | 2015-06-17 | 天津医科大学第二医院 | For laboratory animal PET, CT and MR image co-registration and stationary device |
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