CN204394546U - For laboratory animal PET, CT and MR image co-registration and stationary device - Google Patents
For laboratory animal PET, CT and MR image co-registration and stationary device Download PDFInfo
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- CN204394546U CN204394546U CN201520018515.4U CN201520018515U CN204394546U CN 204394546 U CN204394546 U CN 204394546U CN 201520018515 U CN201520018515 U CN 201520018515U CN 204394546 U CN204394546 U CN 204394546U
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- locating bar
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Abstract
The utility model discloses a kind of for laboratory animal PET, CT and MR image co-registration and stationary device, comprise fixed frame, gripper shoe and three cover locating bars, gripper shoe is provided with multiple dog screw, and dog screw is provided with elastic threads or is provided with static line and clamp nut; The quantity of often overlapping locating bar is identical and be at least three; Fixed frame is fixed with a set of locating bar simultaneously, and has at least two locating bars to be mutually tilt; Often canned respectively in cover locating bar have PET or CT or MR developer, by changing locating bar, for laboratory animal PET, CT or MR tri-kinds of different images data add locating information, realized the Precise fusion of any two or more scanogram by surface point extraction method.This utility model is easy and simple to handle, reusable, while having ensured the safety of animal and staff, for the further investigation of image interfusion method provides foundation, more effectively, accurately, intuitively helps for scientific research and clinical conversion thereof provide.
Description
Technical field
This utility model relate to a kind of fix for laboratory animal and laboratory animal image co-registration in one auxiliary facilities, be specifically related to a kind of small animal position emission tomography (PET), CT and MR image co-registration and stationary device, for the fixing of laboratory animal and PET, CT and MR image co-registration, for the clinical conversion of zoopery and image fusion technology provides foundation.
Background technology
Laboratory animal, as Mus, rabbit etc., is widely used in various medical experiment and scientific research as experimental subject, is one of animal model comparatively commonly used in Modern medical experiment room.But murine all can make resistance to any unconditioned stimulus, even unnecessary injury is caused to experimenter, therefore laboratory animal is fixed particularly important in experimentation.
In recent years, toy in-vivo imaging is widely used in the experiments such as the research of toy disease model, tumor generting machanism, the early stage imaging of tumor, on this basis, judge whether made animal model meets clinical needs, whether institute's transplantation tumor state meets experiment needs and just seem particularly important.
Along with the continuous progress of modern medicine, radiology and computer technology, the development of Medical Imaging Technology is maked rapid progress, and the various medical image based on different image-forming principle emerges in an endless stream.As CT, MR for image anatomy and the PET for functional imaging.These three kinds of imaging modes have imaging advantage unique separately, if its gained image can be merged, then can be early diagnosis and the treatment of disease, provide larger help.Therefore, Medical image fusion has become the focus of modern medicine study, but image co-registration mode is still immature, and can not apply human body research, can only obtain more data by zoopery, finds optimum image interfusion method.
But, of a great variety for laboratory animal stationary device at present, but function singleness, its material mostly is various metallic article, be difficult to compatible multiple imaging device, and laboratory animal or fixture do not fix recognition site, the image co-registration of laboratory animal can not be realized.
Utility model content
For prior art, this utility model provides a kind of for small animal position emission tomography (PET), CT and MR image co-registration and stationary device, the method is by making laboratory animal be fixed by special purpose device, and carry out different imaging mode scanning, the two or three imaging inspection image obtained can accurately repeat to identical aspect, thus two image co-registration are achieved, for research image co-registration methods provide foundation.
In order to solve the problems of the technologies described above, the technical scheme that this utility model is achieved for laboratory animal PET, CT and MR image co-registration and stationary device is: this fixture comprises fixed frame, gripper shoe and three cover locating bars, described fixed frame is made up of the bracing frame at top and many supporting legs, supporting leg is provided with support, and described gripper shoe load is in support; Described gripper shoe is provided with multiple dog screw, one of them dog screw is fixed with an elastic threads, and all the other each dog screws are fixed with static line and clamp nut respectively; Described locating bar is made up of hollow pipe and plug, and often overlapping in locating bar cannedly respectively has PET developer or CT developer or MR developer; The quantity of often overlapping locating bar is identical and be at least three; Described fixed frame is fixed with a set of locating bar simultaneously; Be fixed in a set of locating bar on fixed frame and have at least two locating bars to be mutually tilt.
Compared with prior art, the beneficial effects of the utility model are:
The assembling of this utility model fixture and easy and simple to handle, reusable, while having ensured the safety of laboratory animal and staff, for the image co-registration of toy plurality of medical scanogram provides feasible location measure, more effectively, accurately, intuitively help for scientific research and clinical conversion thereof provide.
The image co-registration of this utility model fixture is utilized to can be applicable in the experimentatioies such as the research of toy disease model, tumor generting machanism, the early stage imaging of tumor, on this basis, judge whether made animal model meets clinical needs, whether institute's transplantation tumor state meets experiment needs.Meanwhile, be conducive to carrying out more zoopery and think that the clinical image interfusion method of optimum that finds provides foundation.There is very important using value.
Accompanying drawing explanation
Fig. 1 is the overall structure schematic diagram of this utility model fixture;
Fig. 2 is the exploded view of fixture shown in body 1.
In figure:
1-gripper shoe 11-static line 12-dog screw 13-elastic threads
14-bolt 15-clamp nut 2-fixed frame 21-bracing frame
22-positioning through hole 23-supports 24-supporting leg 25-base
3-locating bar
Detailed description of the invention
Below in conjunction with the drawings and specific embodiments, technical solutions of the utility model are described in further detail.
As depicted in figs. 1 and 2, this utility model is used for laboratory animal PET, CT and MR image co-registration and stationary device, comprise fixed frame 2, gripper shoe 1 and three cover locating bars 3, described fixed frame 2 is made up of the bracing frame 21 at top and many supporting legs 24, supporting leg 24 is provided with support 23, described gripper shoe 1 is carried on a shoulder pole in support 23, and the bottom of described supporting leg 24 is provided with base 25.
Described gripper shoe 1 is provided with multiple dog screw 12, one of them dog screw 12 is fixed with an elastic threads 13, and all the other each dog screws 12 are fixed with static line 11 and clamp nut 15 respectively.
Described locating bar 3 is made up of hollow pipe and plug, and often overlapping in locating bar 3 cannedly respectively has PET developer or CT developer or MR developer; Often overlap the quantity of locating bar 3 identical and be at least three; Described fixed frame 2 is fixed with a set of locating bar 3 simultaneously, and described fixed frame 2 is provided with positioning through hole 22, and described locating bar 3 is through in positioning through hole 22 and locates.Be fixed in a set of locating bar 3 on fixed frame 2 and have at least two locating bars 3 to be mutually tilt.
Many locating bars 3 relative misalignment is arranged, be conducive to in successive image fusion, the superposition of layer provides positioning datum accurately, because, in image procossing, a plane can be determined at 3, by at least three locating bars 3 of oblique arrangement, as selected four locating bars 3, four points can be provided to determine a plane, the every tomographic image in PET or CT or MR gained image is made all to have each self-corresponding four points, on a kind of image check method gained image based on a certain aspect, according to the datum mark of four on it, the reconstruction image of other two kinds or a kind of inspection method is looked for the aspect of its correspondence, and the two is merged, to realize being accurate to point-to-point image co-registration.
In this utility model, the selection principle of each construction material is: as long as can be applied to PET, CT, MR imaging and not affect the material of imaging effect simultaneously.
This utility model is utilized to the process that laboratory animal carries out medical scanning and image co-registration to be:
Step one, medical scanning is carried out to toy before, the process of fixing toy by this utility model fixture is as follows:
Gripper shoe 1 is carried on a shoulder pole before fixed frame 2, first utilize static line 11 that the extremity of toy are fixed on gripper shoe 1, and static line 11 is wound on dog screw 12, to tighten fixing with clamp nut 15 again, fix the tooth of toy again by the elastic threads 13 on one of them dog screw 12, thus toy has been fixed in gripper shoe 1; Gripper shoe 1 is carried on a shoulder pole in support 23, gripper shoe 1 is inserted in the support 23 on fixed frame 2, keep its relative position to fix; Bracing frame 21 and supporting leg 24 are provided with locating hole 22, the position relative dislocation of locating hole 22, and locating bar 3 can be inserted wherein obliquely, be filled with the developer being applicable to PET, CT or MR imaging respectively in locating bar 3, by base 25, whole device be positioned over scanning bed stably.
Two or more scanograms in step 2, the MR scanogram obtaining the whole body of animal by the following method, PET scanogram and CT scan image, and without tandem:
2 ?A, obtain MR scanogram:
The whole device fixing animal is positioned on MR examinating couch stably, four locating bars 3 of the canned paramagnetic contrast's of having agent are inserted in positioning through hole 22 paired on fixed frame 2 and supporting leg 24, three-dimensional MR scanning is carried out to region of interest, writing scan image information data;
2 ?B, obtain PET scanogram:
The whole support fixing animal is steadily positioned on PET examinating couch, locating bar is changed into canned four locating bars containing PET tracer, carry out PET scanning, and writing scan image information data;
2-C, acquisition CT scan image:
The whole support fixing animal is steadily positioned on CT examination bed, locating bar is changed into canned four locating bars having iodine preparation high density contrast agent, carry out CT scan, and writing scan image information data;
Step 3, from every width scanogram information data that step 2 obtains, to extract the gauge point that locating bar provides by surface extraction method, using this gauge point as the datum mark of image co-registration; Image integration, reconstruction processing is carried out by Photoshop computer software, when realizing three-dimensional PET scanning if had ready conditions, in image co-registration process, optionally can reconstruct the image of required angle by PET, CT or MR scanogram, and with the datum mark in this image for standard, rebuild another or two kinds of scanograms, PET, CT or MR of identical aspect are rebuild image and to merge between two or three is merged simultaneously; When only feasible two-dimensional PE T scans, in image co-registration process, then with the datum mark on PET standard axle position for standard, rebuild CT and/or MR and check figure, finally the PET scanogram information fusion of identical aspect is rebuild on image at CT and/or MR, thus realize in same piece image, show above-mentioned two or more scanogram information.
Although be described this utility model by reference to the accompanying drawings above; but this utility model is not limited to above-mentioned detailed description of the invention; above-mentioned detailed description of the invention is only schematic; instead of it is restrictive; those of ordinary skill in the art is under enlightenment of the present utility model; when not departing from this utility model aim, can also make a lot of distortion, these all belong within protection of the present utility model.
Claims (3)
1., for laboratory animal PET, CT and MR image co-registration and a stationary device, it is characterized in that:
Comprise fixed frame (2), gripper shoe (1) and three covers locating bar (3), described fixed frame (2) is made up of the bracing frame (21) at top and many supporting legs (24), supporting leg (24) is provided with support (23), and described gripper shoe (1) load is in support (23);
Described gripper shoe (1) is provided with multiple dog screw (12), one of them dog screw (12) is fixed with an elastic threads (13), all the other each dog screws (12) is fixed with respectively static line (11) and clamp nut (15);
Described locating bar (3) is made up of hollow pipe and plug, and often overlapping in locating bar (3) cannedly respectively has PET developer or CT developer or MR developer; The quantity of often overlapping locating bar (3) is identical and be at least three; Described fixed frame (2) is fixed with simultaneously a set of locating bar (3); Be fixed in a set of locating bar (3) on fixed frame (2) and have at least two locating bars (3) to be mutually tilt.
2. according to claim 1 for laboratory animal PET, CT and MR image co-registration and stationary device, it is characterized in that, described fixed frame (2) is provided with positioning through hole (22), and described locating bar (3) is through location in positioning through hole (22).
3. according to claim 1 for laboratory animal PET, CT and MR image co-registration and stationary device, it is characterized in that, the bottom of described supporting leg (24) is provided with base (25).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520018515.4U CN204394546U (en) | 2015-01-12 | 2015-01-12 | For laboratory animal PET, CT and MR image co-registration and stationary device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520018515.4U CN204394546U (en) | 2015-01-12 | 2015-01-12 | For laboratory animal PET, CT and MR image co-registration and stationary device |
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| Publication Number | Publication Date |
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| CN204394546U true CN204394546U (en) | 2015-06-17 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201520018515.4U Expired - Fee Related CN204394546U (en) | 2015-01-12 | 2015-01-12 | For laboratory animal PET, CT and MR image co-registration and stationary device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104510489A (en) * | 2015-01-12 | 2015-04-15 | 天津医科大学第二医院 | Device for PET-CT-MR image fusion and fixation of experimental animal |
-
2015
- 2015-01-12 CN CN201520018515.4U patent/CN204394546U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104510489A (en) * | 2015-01-12 | 2015-04-15 | 天津医科大学第二医院 | Device for PET-CT-MR image fusion and fixation of experimental animal |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150617 Termination date: 20170112 |
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| CF01 | Termination of patent right due to non-payment of annual fee |