CN104510489A - Device for PET-CT-MR image fusion and fixation of experimental animal - Google Patents
Device for PET-CT-MR image fusion and fixation of experimental animal Download PDFInfo
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- CN104510489A CN104510489A CN201510014476.5A CN201510014476A CN104510489A CN 104510489 A CN104510489 A CN 104510489A CN 201510014476 A CN201510014476 A CN 201510014476A CN 104510489 A CN104510489 A CN 104510489A
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Abstract
The invention discloses a device for PET-CT-MR image fusion and fixation of an experimental animal. The device comprises a fixed frame, a support plate and three sets of positioning rods, wherein a plurality of positioning screws are arranged on the support plate, an elastic rope is arranged on one positioning screw, and fixing ropes and clamp nuts are arranged on the other positioning screws; the three sets of positioning rods have the same number (at least three) of positioning rods; one set of positioning rods is fixed on the fixed frame simultaneously, wherein at least two positioning rods are inclined relative to each other; the positioning rods in each set are filled with PET, CT and MR photographic developers respectively, the positioning rods can be changed to add positioning information to three different image data of the experimental animal, namely PET image data, CT image data and MR image data, and accurate fusion of any more than two scan images is realized by an external feature point extraction method. The device is simple and convenient to operate, can be used repeatedly, guarantees the safety of the animal and workers, meanwhile provides a basis for deep study on image fusion methods and provides more effective, accurate and visual aid for scientific research and clinic and translation thereof.
Description
Technical field
The present invention relates to a kind of fix for laboratory animal and laboratory animal image co-registration in one auxiliary facilities, be specifically related to a kind of small animal position emission tomography (PET), CT and MR image co-registration and stationary device, for the fixing of laboratory animal and PET, CT and MR image co-registration, for the clinical conversion of zoopery and image fusion technology provides foundation.
Background technology
Laboratory animal, as Mus, rabbit etc., is widely used in various medical experiment and scientific research as experimental subject, is one of animal model comparatively commonly used in Modern medical experiment room.But murine all can make resistance to any unconditioned stimulus, even unnecessary injury is caused to experimenter, therefore laboratory animal is fixed particularly important in experimentation.
In recent years, toy in-vivo imaging is widely used in the experiments such as the research of toy disease model, tumor generting machanism, the early stage imaging of tumor, on this basis, judge whether made animal model meets clinical needs, whether institute's transplantation tumor state meets experiment needs and just seem particularly important.
Along with the continuous progress of modern medicine, radiology and computer technology, the development of Medical Imaging Technology is maked rapid progress, and the various medical image based on different image-forming principle emerges in an endless stream.As CT, MR for image anatomy and the PET for functional imaging.These three kinds of imaging modes have imaging advantage unique separately, if its gained image can be merged, then can be early diagnosis and the treatment of disease, provide larger help.Therefore, Medical image fusion has become the focus of modern medicine study, but image co-registration mode is still immature, and can not apply human body research, can only obtain more data by zoopery, finds optimum image interfusion method.
But, of a great variety for laboratory animal stationary device at present, but function singleness, its material mostly is various metallic article, be difficult to compatible multiple imaging device, and laboratory animal or fixture do not fix recognition site, the image co-registration of laboratory animal can not be realized.
Summary of the invention
For prior art, the invention provides a kind of for small animal position emission tomography (PET), CT and MR image co-registration and stationary device, the method is by making laboratory animal be fixed by special purpose device, and carry out different imaging mode scanning, the two or three imaging inspection image obtained can accurately repeat to identical aspect, thus two image co-registration are achieved, for research image co-registration methods provide foundation.
In order to solve the problems of the technologies described above, the technical scheme that the present invention is achieved for laboratory animal PET, CT and MR image co-registration and stationary device is: this fixture comprises fixed frame, gripper shoe and three cover locating bars, described fixed frame is made up of the bracing frame at top and many supporting legs, supporting leg is provided with support, and described gripper shoe load is in support; Described gripper shoe is provided with multiple dog screw, one of them dog screw is fixed with an elastic threads, and all the other each dog screws are fixed with static line and clamp nut respectively; Described locating bar is made up of hollow pipe and plug, and often overlapping in locating bar cannedly respectively has PET developer or CT developer or MR developer; The quantity of often overlapping locating bar is identical and be at least three; Described fixed frame is fixed with a set of locating bar simultaneously; Be fixed in a set of locating bar on fixed frame and have at least two locating bars to be mutually tilt.
Compared with prior art, the invention has the beneficial effects as follows:
The assembling of fixture of the present invention and easy and simple to handle, reusable, while having ensured the safety of laboratory animal and staff, for the image co-registration of toy plurality of medical scanogram provides feasible location measure, more effectively, accurately, intuitively help for scientific research and clinical conversion thereof provide.
The image co-registration of fixture of the present invention is utilized to can be applicable in the experimentatioies such as the research of toy disease model, tumor generting machanism, the early stage imaging of tumor, on this basis, judge whether made animal model meets clinical needs, whether institute's transplantation tumor state meets experiment needs.Meanwhile, be conducive to carrying out more zoopery and think that the clinical image interfusion method of optimum that finds provides foundation.There is very important using value.
Accompanying drawing explanation
Fig. 1 is the overall structure schematic diagram of fixture of the present invention;
Fig. 2 is the exploded view of fixture shown in body 1.
In figure:
1-gripper shoe 11-static line 12-dog screw 13-elastic threads
14-bolt 15-clamp nut 2-fixed frame 21-bracing frame
22-positioning through hole 23-supports 24-supporting leg 25-base
3-locating bar
Detailed description of the invention
Below in conjunction with the drawings and specific embodiments, technical solution of the present invention is described in further detail.
As depicted in figs. 1 and 2, the present invention is used for laboratory animal PET, CT and MR image co-registration and stationary device, comprise fixed frame 2, gripper shoe 1 and three cover locating bars 3, described fixed frame 2 is made up of the bracing frame 21 at top and many supporting legs 24, supporting leg 24 is provided with support 23, described gripper shoe 1 is carried on a shoulder pole in support 23, and the bottom of described supporting leg 24 is provided with base 25.
Described gripper shoe 1 is provided with multiple dog screw 12, one of them dog screw 12 is fixed with an elastic threads 13, and all the other each dog screws 12 are fixed with static line 11 and clamp nut 15 respectively.
Described locating bar 3 is made up of hollow pipe and plug, and often overlapping in locating bar 3 cannedly respectively has PET developer or CT developer or MR developer; Often overlap the quantity of locating bar 3 identical and be at least three; Described fixed frame 2 is fixed with a set of locating bar 3 simultaneously, and described fixed frame 2 is provided with positioning through hole 22, and described locating bar 3 is through in positioning through hole 22 and locates.Be fixed in a set of locating bar 3 on fixed frame 2 and have at least two locating bars 3 to be mutually tilt.
Many locating bars 3 relative misalignment is arranged, be conducive to in successive image fusion, the superposition of layer provides positioning datum accurately, because, in image procossing, a plane can be determined at 3, by at least three locating bars 3 of oblique arrangement, as selected four locating bars 3, four points can be provided to determine a plane, the every tomographic image in PET or CT or MR gained image is made all to have each self-corresponding four points, on a kind of image check method gained image based on a certain aspect, according to the datum mark of four on it, the reconstruction image of other two kinds or a kind of inspection method is looked for the aspect of its correspondence, and the two is merged, to realize being accurate to point-to-point image co-registration.
In the present invention, the selection principle of each construction material is: as long as can be applied to PET, CT, MR imaging and not affect the material of imaging effect simultaneously.
The present invention is utilized to the process that laboratory animal carries out medical scanning and image co-registration to be:
Step one, medical scanning is carried out to toy before, the process of fixing toy by fixture of the present invention is as follows:
Gripper shoe 1 is carried on a shoulder pole before fixed frame 2, first utilize static line 11 that the extremity of toy are fixed on gripper shoe 1, and static line 11 is wound on dog screw 12, to tighten fixing with clamp nut 15 again, fix the tooth of toy again by the elastic threads 13 on one of them dog screw 12, thus toy has been fixed in gripper shoe 1; Gripper shoe 1 is carried on a shoulder pole in support 23, gripper shoe 1 is inserted in the support 23 on fixed frame 2, keep its relative position to fix; Bracing frame 21 and supporting leg 24 are provided with locating hole 22, the position relative dislocation of locating hole 22, and locating bar 3 can be inserted wherein obliquely, be filled with the developer being applicable to PET, CT or MR imaging respectively in locating bar 3, by base 25, whole device be positioned over scanning bed stably.
Two or more scanograms in step 2, the MR scanogram obtaining the whole body of animal by the following method, PET scanogram and CT scan image, and without tandem:
2 ?A, obtain MR scanogram:
The whole device fixing animal is positioned on MR examinating couch stably, four locating bars 3 of the canned paramagnetic contrast's of having agent are inserted in positioning through hole 22 paired on fixed frame 2 and supporting leg 24, three-dimensional MR scanning is carried out to region of interest, writing scan image information data;
2 ?B, obtain PET scanogram:
The whole support fixing animal is steadily positioned on PET examinating couch, locating bar is changed into canned four locating bars containing PET tracer, carry out PET scanning, and writing scan image information data;
2-C, acquisition CT scan image:
The whole support fixing animal is steadily positioned on CT examination bed, locating bar is changed into canned four locating bars having iodine preparation high density contrast agent, carry out CT scan, and writing scan image information data;
Step 3, from every width scanogram information data that step 2 obtains, to extract the gauge point that locating bar provides by surface extraction method, using this gauge point as the datum mark of image co-registration; Image integration, reconstruction processing is carried out by Photoshop computer software, when realizing three-dimensional PET scanning if had ready conditions, in image co-registration process, optionally can reconstruct the image of required angle by PET, CT or MR scanogram, and with the datum mark in this image for standard, rebuild another or two kinds of scanograms, PET, CT or MR of identical aspect are rebuild image and to merge between two or three is merged simultaneously; When only feasible two-dimensional PE T scans, in image co-registration process, then with the datum mark on PET standard axle position for standard, rebuild CT and/or MR and check figure, finally the PET scanogram information fusion of identical aspect is rebuild on image at CT and/or MR, thus realize in same piece image, show above-mentioned two or more scanogram information.
Although invention has been described by reference to the accompanying drawings above; but the present invention is not limited to above-mentioned detailed description of the invention; above-mentioned detailed description of the invention is only schematic; instead of it is restrictive; those of ordinary skill in the art is under enlightenment of the present invention; when not departing from present inventive concept, can also make a lot of distortion, these all belong within protection of the present invention.
Claims (3)
1., for laboratory animal PET, CT and MR image co-registration and a stationary device, it is characterized in that:
Comprise fixed frame (2), gripper shoe (1) and three covers locating bar (3), described fixed frame (2) is made up of the bracing frame (21) at top and many supporting legs (24), supporting leg (24) is provided with support (23), and described gripper shoe (1) load is in support (23);
Described gripper shoe (1) is provided with multiple dog screw (12), one of them dog screw (12) is fixed with an elastic threads (13), all the other each dog screws (12) is fixed with respectively static line (11) and clamp nut (15);
Described locating bar (3) is made up of hollow pipe and plug, and often overlapping in locating bar (3) cannedly respectively has PET developer or CT developer or MR developer; The quantity of often overlapping locating bar (3) is identical and be at least three; Described fixed frame (2) is fixed with simultaneously a set of locating bar (3); Be fixed in a set of locating bar (3) on fixed frame (2) and have at least two locating bars (3) to be mutually tilt.
2. according to claim 1 for laboratory animal PET, CT and MR image co-registration and stationary device, it is characterized in that, described fixed frame (2) is provided with positioning through hole (22), and described locating bar (3) is through location in positioning through hole (22).
3. according to claim 1 for laboratory animal PET, CT and MR image co-registration and stationary device, it is characterized in that, the bottom of described supporting leg (24) is provided with base (25).
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510014476.5A CN104510489B (en) | 2015-01-12 | 2015-01-12 | Device for PET-CT-MR image fusion and fixation of experimental animal |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510014476.5A CN104510489B (en) | 2015-01-12 | 2015-01-12 | Device for PET-CT-MR image fusion and fixation of experimental animal |
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| CN104510489A true CN104510489A (en) | 2015-04-15 |
| CN104510489B CN104510489B (en) | 2017-02-08 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116115245A (en) * | 2023-02-14 | 2023-05-16 | 重庆全景红岭医学影像诊断中心有限公司 | Stereotactic frame for fusion of abdominal basin PET, CT and MR images |
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| CN201131816Y (en) * | 2007-12-04 | 2008-10-15 | 中日友好医院 | Multifunctional test operation table |
| KR20100072873A (en) * | 2008-12-22 | 2010-07-01 | 울산대학교 산학협력단 | Apparatus fixing the position and location of mouse for imaging acquisition with multiple modalities |
| WO2012076660A1 (en) * | 2010-12-08 | 2012-06-14 | Universiteit Antwerpen | Animal positioning for in-vivo imaging |
| CN203234754U (en) * | 2013-04-17 | 2013-10-16 | 中国人民解放军第三军医大学第二附属医院 | Animal fixing bed used for imaging examination |
| CN103735252A (en) * | 2014-01-14 | 2014-04-23 | 中国科学院自动化研究所 | Multi-modal optical imaging system and multi-modal optical imaging method |
| CN204394546U (en) * | 2015-01-12 | 2015-06-17 | 天津医科大学第二医院 | For laboratory animal PET, CT and MR image co-registration and stationary device |
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- 2015-01-12 CN CN201510014476.5A patent/CN104510489B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201131816Y (en) * | 2007-12-04 | 2008-10-15 | 中日友好医院 | Multifunctional test operation table |
| KR20100072873A (en) * | 2008-12-22 | 2010-07-01 | 울산대학교 산학협력단 | Apparatus fixing the position and location of mouse for imaging acquisition with multiple modalities |
| WO2012076660A1 (en) * | 2010-12-08 | 2012-06-14 | Universiteit Antwerpen | Animal positioning for in-vivo imaging |
| CN203234754U (en) * | 2013-04-17 | 2013-10-16 | 中国人民解放军第三军医大学第二附属医院 | Animal fixing bed used for imaging examination |
| CN103735252A (en) * | 2014-01-14 | 2014-04-23 | 中国科学院自动化研究所 | Multi-modal optical imaging system and multi-modal optical imaging method |
| CN204394546U (en) * | 2015-01-12 | 2015-06-17 | 天津医科大学第二医院 | For laboratory animal PET, CT and MR image co-registration and stationary device |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN116115245A (en) * | 2023-02-14 | 2023-05-16 | 重庆全景红岭医学影像诊断中心有限公司 | Stereotactic frame for fusion of abdominal basin PET, CT and MR images |
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| CN104510489B (en) | 2017-02-08 |
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