CN103735252A - Multi-modal optical imaging system and multi-modal optical imaging method - Google Patents
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Abstract
The invention discloses a multi-modal optical imaging system. The multi-modal optical imaging system comprises a supporting base, a rotary platform, an MRI (magnetic resonance imaging) system support, a to-be-imaged object table support, a to-be-imaged object table, a CT (computed tomography) system, a fluorescence imaging system, a PET (positron emission tomography) system, an MRI system and a computer. The supporting base is fixed to the ground and used for supporting a linear guide rail, the MRI system support and the rotary platform, the CT system, the fluorescence imaging system and the PET system are mounted on the rotary platform, the MRI system is mounted on the MRI system support, the to-be-imaged object table support is mounted on the linear guide rail, and the to-be-imaged object table is fixed onto the to-be-imaged object table support. The CT system is used for acquiring sectional anatomy structural images of to-be-imaged objects, the fluorescence imaging system is used for acquiring two-dimensional fluorescence images of the to-be-imaged objects, the PET system is used for acquiring PET images of the to-be-imaged objects, the MRI system is used for acquiring MRI images of the to-be-imaged objects, and the computer is used for receiving and processing the images to obtain three-dimensional images of the to-be-imaged objects. The invention further provides a multi-modal optical imaging method. The multi-modal optical imaging system and the multi-modal optical imaging can be used for fusion three-dimensional optical imaging of small animals in clinical trials.
Description
Technical field
The present invention relates to optical molecular imaging technical field, particularly a kind of optics multi-mode imaging system and method.
Background technology
In recent years, along with the develop rapidly of optical molecular Imaging Technology, some are applied to the imaging technique of medical science, as CT, ultrasonic, magnetic resonance, radionuclide imaging, positron emission computerized tomography (PET), and the fusion of imaging technology such as PET/CT plays an important role in life sciences and pre-clinical research.CT imaging resolution is high, there is no imaging depth restriction, anatomical information can be provided, but can not carry out good imaging to soft tissue.Fluorescence fault imaging (FMT) utilizes optical molecular probe, the target tissue of probe is carried out to physiology and pathology detection, autofluorescence fault imaging (BLT) utilizes the fluorescence that organism self sends to carry out imaging, when Cherenkov's fault imaging (CLT) utilizes the radionuclide charged particle that produces movement velocity in its medium in the process of decay to be greater than the movement velocity of light in this medium, the Cherenkov light producing carries out imaging, but the method for these optical imageries, imaging depth is shallow, and resolution is lower.PET imaging has good specificity, and functional metabolism information can be provided, but its sensitivity and resolution are lower.How can be by multiple modalities imaging device fusion of imaging, the information based on each Modal detection is carried out fusion of imaging, thus the deficiency that overcomes the information such as physiology, pathology and structure that single mode provides is the focus of optical molecular iconography research always.
There are a lot of research institutions both at home and abroad by the single mode system of a lot of maturations, as fusion of imaging is carried out in CT, PET, FMT and magnetic resonance (MRI) etc., thereby obtain the much information of tested organism.The application FMT/CT emerging systems such as Angelique A detect mice cervical region and lung tumors, result demonstration, and the FMT result that has merged CT information is more accurate.Li C etc. build a kind of FMT/PET system, and the system and method for a kind of FMT and PET double-mode imaging is provided.In addition, the people such as Nahrendorf M utilize business PET/CT and FMT to carry out mice imaging in vivo, and mobile animal storehouse of placing mice, carries out each mode imaging according to this.In this system and imaging mode, because mice needs to move, will certainly cause posture and the change in location of some mices, final imaging meeting is impacted.At present, the system of two kinds of mode can be accomplished same machine imaging, but most three kinds of mode or above optical molecular imaging system are toy to be carried out respectively in each modal system to imaging, and then image is merged.The mode of above-mentioned multi-modal fusion imaging, makes toy wait for that the position of imaging object produces change in moving process.Therefore, the image obtaining need to be proofreaied and correct through algorithm, has so both increased the time of rebuilding image, and the quality of reconstruction image is also difficult to be guaranteed.
Summary of the invention
In order to solve above-mentioned problems of the prior art, the present invention proposes a kind of optics multi-mode imaging system and method, the present invention waits for the CT system in the single mode imaging of imaging object to be generally used for toy, fluorescence imaging system and PET imaging system are basic equipment, a kind of multi-modality imaging method that merges MRI imaging take same machine is as core, with machine, gather CT, the faultage image of FMT/BLT/CLT, PET image and MRI image, and the two dimensional image collecting is carried out to three-dimensional reconstruction through graphics processing card, thereby obtain physiology and the three-dimensional fusion image of pathology of object to be imaged.
According to an aspect of the present invention, a kind of optics multi-mode imaging system is proposed, this system comprises: base for supporting, rotation platform, CT system, fluorescence imaging system, PET system, MRI system, MRI system frame, line slideway, object platform to be imaged, object bedrest to be imaged and computer, wherein:
Described base for supporting is fixed on ground;
Described rotation platform is arranged on one end of described base for supporting perpendicular to ground, the center of its center of rotation and object to be imaged is in same level line, described CT system, fluorescence imaging system and PET system are installed evenly distributedly, for being rotated according to the imaging requirements of CT system and fluorescence imaging system on the surface of described rotation platform;
Described CT system is connected with described computer by CT dedicated data line, for continuously gathering the cross sectional anatomy structural images of object to be imaged at rotation platform rotary course, and the cross sectional anatomy structural images collecting is transferred in described computer and processes and preserve;
Described fluorescence imaging system is connected with described computer by USB or serial line interface data wire, for after rotation platform rotates to fixed angle and stops, continuously detect the fluorescence signal in object body to be imaged, obtain two-dimentional fluoroscopic image, and the fluoroscopic image collecting is transferred in described computer and processes and preserve;
Described PET system is connected with described computer by PET detector dedicated data line, for fixing at rotation platform and when rectilinear translation platform moves PET detector and forms closed area, continuously gather the PET image of object to be imaged, and the PET image transmitting obtaining is processed and preserved to described computer;
Described MRI system frame is arranged on a side of base for supporting perpendicular to ground, the center of its center and object to be imaged is in same level line;
Described MRI system is connected with described computer, be arranged in described MRI system frame, the center of rotation of its imaging center and described rotation platform is in same level line, for continuously gathering the MRI image of object to be imaged, and the MRI image transmitting obtaining is processed and preserved to described computer;
Described line slideway is arranged on the upper surface of described base for supporting, and described line slideway is provided with Communications Control Interface, for connecting described computer, with the control instruction according to described computer, moves;
Described object bedrest to be imaged is installed on described line slideway;
Described object bed to be imaged is fixed on described object bedrest to be imaged, for placing object to be imaged;
Described computer, for receiving the image of described CT system, fluorescence imaging system, PET system and the transmission of MRI system and it being preserved and is processed, finally obtains the 3-D view of object to be imaged
According to a further aspect in the invention, also propose a kind of optics multi-modality imaging method, the method comprises the following steps:
Step 1, computer control rectilinear translation platform moves PET detector and forms a closed area, starts to treat imaging object and carries out PET imaging, obtains PET view data, and described PET image data transmission is stored to described computer;
Due in whole imaging process, object to be imaged is fixed on object platform to be imaged all the time, multiple image mode is treated imaging object all angles and is carried out fault imaging, finally by crossing graphics processing card, two dimensional image is carried out to three-dimensional reconstruction, the image of multiple modalities can be by mutual supplement with each other's advantages separately, overcome the deficiency of single mode, improve picture quality.Therefore, the present invention can be used for machine, merging in the experiment of pre-clinical toy wait imaging object the optical molecular imaging of MRI.
Accompanying drawing explanation
Fig. 1 is the structural representation of optics multi-mode imaging system of the present invention;
Fig. 2 is the structure front view of the rotation platform of optics multi-mode imaging system of the present invention;
Fig. 3 is the flow chart of optics multi-modality imaging method of the present invention.
The specific embodiment
For making the object, technical solutions and advantages of the present invention clearer, below in conjunction with specific embodiment, and with reference to accompanying drawing, the present invention is described in more detail.
Fig. 1 is the structural representation of optics multi-mode imaging system of the present invention, as shown in Figure 1, described optics multi-mode imaging system comprises: MRI system 1, object platform 3 to be imaged, object platform support 4 to be imaged, line slideway 5, rotation platform 6, CT system, fluorescence imaging system, MRI system frame 10, PET system, base for supporting 11 and computer, wherein:
Described base for supporting 11 is fixed on ground;
Described rotation platform 6 is arranged on one end of described base for supporting 11 perpendicular to ground, the center of its center of rotation and object to be imaged is in same level line, described CT system, fluorescence imaging system and PET system are installed evenly distributedly, for being rotated according to the imaging requirements of CT system and fluorescence imaging system on the surface of described rotation platform 6;
Described MRI system frame 10 is arranged on a side of base for supporting 11 perpendicular to ground, the center of its center and object to be imaged, in same level line, is provided with described MRI system 1 in described MRI system frame 10;
Described MRI system 1 is connected with described computer, the center of rotation of its imaging center and described rotation platform 6 is in same level line, for continuously gathering the MRI image of object to be imaged, and the MRI image transmitting obtaining is processed and preserved to described computer;
Described MRI system 1 comprises main magnet 8 and radio-frequency coil 2, and described main magnet 8 is provided for the magnetic field of imaging, and radio-frequency coil 2 is provided for the pulse train of imaging;
Described line slideway 5 is arranged on the upper surface of described base for supporting 11, for object platform support 4 to be imaged mobile mounted thereto, described line slideway 5 is provided with Communications Control Interface, for connecting described computer, with the control instruction according to described computer, moves;
Described object platform support 4 to be imaged is installed on described line slideway;
Described object platform 3 to be imaged is fixed on described object platform support 4 to be imaged, for placing object to be imaged;
Described multiple rectilinear translation platform 24 is installed on rotation platform 6, and orthogonal thereto layout, for carrying CT system, fluorescence imaging system and PET system, described rectilinear translation platform 24 is provided with Communications Control Interface, be connected with described computer, with the control instruction according to described computer, move;
Described CT system is connected with described computer by CT dedicated data line, for continuously gathering the cross sectional anatomy structural images of object to be imaged at rotation platform 6 rotary courses, and the cross sectional anatomy structural images collecting is transferred in described computer and processes and preserve;
Described CT system comprises X-ray tube 23 and X-ray detector 7, wherein, X-ray tube 23 is relative with X-ray detector 7 to be arranged on described rotation platform 6, the center of ray mouth, object to be imaged center and the X-ray detector 7 of described X-ray tube 23 is on same straight line, to guarantee CT picture quality;
Described fluorescence imaging system is connected with described computer by USB or serial line interface data wire, for after rotation platform 6 rotates to fixed angle and stops, continuously detect the fluorescence signal in object body to be imaged, obtain two-dimentional fluoroscopic image, and the fluoroscopic image collecting is transferred in described computer and processes and preserve;
Described fluorescence imaging system comprises laser instrument 9 and CCD camera 21, wherein, laser instrument 9 is relative with CCD camera 21 to be installed on rotation platform 6, the visual field of described CCD camera 21 needs to comprise object whole body to be imaged completely, the laser irradiation that laser instrument 9 sends, to object to be imaged, produces fluorescence excitation, the now fluorescence signal in CCD camera 21 continuous detecting object body to be imaged in object body to be imaged, form a width two dimension fluoroscopic image, and be transferred in described computer;
Described PET system is connected with described computer by PET detector dedicated data line, when moving PET detector 22 and forming closed area for and rectilinear translation platform 24 fixing at rotation platform 6, continuously gather the PET image of object to be imaged, and the PET image transmitting obtaining is processed and preserved to described computer;
Described PET system comprises multiple PET detectors 22, the quantity of described PET detector 22 is even-even, and be no less than four groups, described PET detector 22 is installed on rectilinear translation platform 24, in object body to be imaged, after injection radiosiotope, radiate gammaphoton, by rectilinear translation platform 24, move PET detector 22 and form closed area, PET detector 22 detects the gammaphoton sending by object body to be imaged, after opto-electronic conversion, obtain PET image, and by obtained PET image transmitting in described computer;
Described computer is provided with graphics processing card and can supports figure parallel computation, described graphics processing card and rectilinear translation platform 24, CT system, fluorescence imaging system, PET system is connected with MRI system, for continuously gathering the image that each imaging system obtains, and the image collecting is processed, such as position registration, image co-registration etc., and be 3-D view by two-dimension image rebuild after treatment, be that described computer receives described CT system, fluorescence imaging system, the image that PET system and MRI system send is also preserved and is processed it, finally obtain the 3-D view of object to be imaged,
Communication control interface for connecting line slideway 5 and rectilinear translation platform 24 is also housed on described computer, this interface can be USB interface or serial line interface, these interfaces are connected with rectilinear translation platform 24 with line slideway 5 by USB line or string line, can read its kinematic parameter from line slideway 5 and rectilinear translation platform 24, such as position and speed parameter, and the parameter of acquisition is returned to described computer, described computer sends control instruction according to the parameter obtaining, and controls line slideway 5 and rectilinear translation platform 24 and moves.
Fig. 3 is the flow chart of optics multi-modality imaging method of the present invention, and as shown in Figure 3, described multi-modality imaging method comprises the following steps:
Step 1, computer control rectilinear translation platform moves PET detector and forms a closed area, starts to treat imaging object and carries out PET imaging, obtains PET view data, and described PET image data transmission is stored to described computer;
Wherein, the image acquisition of MRI system can also can be carried out before the imaging system collection of other mode after the imaging system collection of other mode finishes.
Above-described specific embodiment; object of the present invention, technical scheme and beneficial effect are further described; institute is understood that; the foregoing is only specific embodiments of the invention; be not limited to the present invention; within the spirit and principles in the present invention all, any modification of making, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (10)
1. an optics multi-mode imaging system, it is characterized in that, this system comprises: base for supporting, rotation platform, CT system, fluorescence imaging system, PET system, MRI system, MRI system frame, line slideway, object platform to be imaged, object platform support to be imaged and computer, wherein:
Described base for supporting is fixed on ground;
Described rotation platform is arranged on one end of described base for supporting perpendicular to ground, the center of its center of rotation and object to be imaged is in same level line, described CT system, fluorescence imaging system and PET system are installed evenly distributedly, for being rotated according to the imaging requirements of CT system and fluorescence imaging system on the surface of described rotation platform;
Described CT system is connected with described computer by CT dedicated data line, for continuously gathering the cross sectional anatomy structural images of object to be imaged at rotation platform rotary course, and the cross sectional anatomy structural images collecting is transferred in described computer and processes and preserve;
Described fluorescence imaging system is connected with described computer by USB or serial line interface data wire, for after rotation platform rotates to fixed angle and stops, continuously detect the fluorescence signal in object body to be imaged, obtain two-dimentional fluoroscopic image, and the fluoroscopic image collecting is transferred in described computer and processes and preserve;
Described PET system is connected with described computer by PET detector dedicated data line, for fixing at rotation platform and when rectilinear translation platform moves PET detector and forms closed area, continuously gather the PET image of object to be imaged, and the PET image transmitting obtaining is processed and preserved to described computer;
Described MRI system frame is arranged on a side of base for supporting perpendicular to ground, the center of its center and object to be imaged is in same level line;
Described MRI system is connected with described computer, be arranged in described MRI system frame, the center of rotation of its imaging center and described rotation platform is in same level line, for continuously gathering the MRI image of object to be imaged, and the MRI image transmitting obtaining is processed and preserved to described computer;
Described line slideway is arranged on the upper surface of described base for supporting, and described line slideway is provided with Communications Control Interface, for connecting described computer, with the control instruction according to described computer, moves;
Described object platform support to be imaged is installed on described line slideway;
Described object platform to be imaged is fixed on described object platform support to be imaged, for placing object to be imaged;
Described computer, for receiving the image of described CT system, fluorescence imaging system, PET system and the transmission of MRI system and it being preserved and is processed, finally obtains the 3-D view of object to be imaged.
2. system according to claim 1, is characterized in that, described MRI system comprises main magnet and radio-frequency coil, and described main magnet is provided for the magnetic field of imaging, and radio-frequency coil is provided for the pulse train of imaging.
3. system according to claim 1, it is characterized in that, on described rotation platform, be provided with: CCD camera, laser instrument, PET detector, X-ray tube, X-ray detector and multiple rectilinear translation platform, wherein, described multiple rectilinear translation platform is installed on rotation platform, and orthogonal thereto layout, for carrying CT system, fluorescence imaging system and PET system.
4. system according to claim 3, is characterized in that, described rectilinear translation platform is provided with Communications Control Interface, is connected with described computer, with the control instruction according to described computer, moves.
5. system according to claim 3, it is characterized in that, described CT system comprises X-ray tube and X-ray detector, wherein, X-ray tube is relative with X-ray detector to be arranged on described rotation platform, and the center of ray mouth, object to be imaged center and the X-ray detector of described X-ray tube is on same straight line.
6. system according to claim 3, it is characterized in that, described fluorescence imaging system comprises laser instrument and CCD camera, wherein, laser instrument is relative with CCD camera to be installed on rotation platform, and the visual field of described CCD camera comprises object whole body to be imaged completely, the laser irradiation that laser instrument sends is to object to be imaged, in object body to be imaged, produce fluorescence excitation, the fluorescence signal in CCD camera continuous detecting object body to be imaged, forms a width two dimension fluoroscopic image.
7. system according to claim 3, it is characterized in that, described PET system comprises multiple PET detectors, described PET detector is installed on rectilinear translation platform, in object body to be imaged, after injection radiosiotope, radiate gammaphoton, by rectilinear translation platform, moved PET detector and formed closed area, PET detector detects by the gammaphoton sending in object body to be imaged, obtains PET image after opto-electronic conversion.
8. system according to claim 7, is characterized in that, the quantity of described PET detector is even-even, and is no less than four groups.
9. system according to claim 3, it is characterized in that, described computer is connected with rectilinear translation platform with line slideway by communication control interface, reads its kinematic parameter, described computer sends control instruction according to the kinematic parameter obtaining, and controls line slideway and rectilinear translation platform and moves.
10. an optics multi-modality imaging method, is characterized in that, the method comprises the following steps:
Step 1, computer control rectilinear translation platform moves PET detector and forms a closed area, starts to treat imaging object and carries out PET imaging, obtains PET view data, and described PET image data transmission is stored to described computer;
Step 2, computer control rectilinear translation platform is removed PET detector, fluorescence imaging system is started working, open laser instrument, by laser irradiation to object to be imaged, CCD camera continuously gathers the fluorescence signal sending in object body to be imaged, obtains two-dimentional fluoroscopic image, and described two-dimentional fluoroscopic image is transferred in described computer and stored;
Step 3, after the complete width two dimension fluoroscopic image of described fluorescence imaging system acquisition, rotation platform starts rotation, CT system starts the cross sectional anatomy structural images of continuous acquisition object to be imaged simultaneously, and the cross sectional anatomy structural image data obtaining is transferred in described computer and processes and store, after rotation platform half-twist, stop;
Step 4, the image acquisition of fluorescence imaging system and CT system in repeating said steps 2 and step 3, until rotation platform rotating 360 degrees completes the collection of all two-dimentional fluoroscopic images and cross sectional anatomy structural images;
Step 5, computer control line slideway moves object platform to be imaged, the center of object to be imaged is moved to the center of MRI detector, starts to treat imaging object and carries out MRI imaging, obtain MRI view data, and described MRI image data transmission is stored to described computer;
Step 6, described computer is processed all two dimensional images that obtain, and utilizes the 3-D view of two-dimension image rebuild object to be imaged, and it is preserved.
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| CN104596869A (en) * | 2015-02-02 | 2015-05-06 | 河海大学 | Test method of four-dimensional dynamic quantitative analysis during soil shear failure |
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| CN107080538A (en) * | 2017-03-21 | 2017-08-22 | 中国医学科学院北京协和医院 | Toy autofluorescence and magnetic resonance bimodal molecule fusion of imaging system and method |
| CN108057178A (en) * | 2017-12-20 | 2018-05-22 | 西安交通大学医学院第附属医院 | Radiotherapy spinning imaging device |
| CN108057178B (en) * | 2017-12-20 | 2020-01-14 | 西安交通大学医学院第一附属医院 | Radiotherapy autogyration imaging device |
| CN108784726A (en) * | 2018-07-18 | 2018-11-13 | 宁波大学 | PET-MRI imaging devices |
| CN112754510A (en) * | 2021-01-11 | 2021-05-07 | 明峰医疗系统股份有限公司 | PET-CT scanning system and method |
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