CN103735252B - An optical multi-modality imaging system and method - Google Patents

An optical multi-modality imaging system and method Download PDF

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CN103735252B
CN103735252B CN201410017482.1A CN201410017482A CN103735252B CN 103735252 B CN103735252 B CN 103735252B CN 201410017482 A CN201410017482 A CN 201410017482A CN 103735252 B CN103735252 B CN 103735252B
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imaged
object
system
pet
computer
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CN103735252A (en
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田捷
惠辉
董迪
詹诗杰
杨鑫
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中国科学院自动化研究所
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Abstract

本发明公开了一种光学多模态成像系统,该系统包括:支撑底座,固定于地面,用于支撑直线导轨、MRI系统支架和旋转平台;旋转平台,安装有CT系统、荧光成像系统和PET系统;MRI系统支架,安装有MRI系统;待成像物体平台支架,安装于直线导轨上;待成像物体平台,固定于待成像物体平台支架上;CT系统,用于采集待成像物体的断层解剖结构图像;荧光成像系统,用于采集待成像物体的二维荧光图像;PET系统,用于采集待成像物体的PET图像;MRI系统,用于采集待成像物体的MRI图像;计算机,接收图像并对其进行处理,得到待成像物体的三维图像。 The present invention discloses an optical multi-modality imaging system, the system comprising: a support base, fixed to the ground, for supporting the linear guide, MRI systems and stents rotating platform; rotating platform is attached to a CT system, a fluorescence imaging system and PET system; bracket MRI system, the MRI system is installed; object to be imaged platform holder, mounted on the linear guide; internet object to be imaged, fixed to the object to be imaged internet stent; CT system for collecting tomographic anatomy of the object to be imaged image; fluorescence imaging system for acquisition of two-dimensional fluorescence image of the object to be imaged; PET system, the PET image acquired for the object to be imaged; MRI systems, MRI images acquired for the object to be imaged; computer, receives an image and thereof, to give the three-dimensional image of the object to be imaged. 本发明还提出一种光学多模态成像方法。 The present invention also provides an optical multi-modality imaging method. 本发明可用于小动物预临床实验中对小动物等待成像物体进行同机融合三维光学成像。 The present invention can be used in pre-clinical small animal experiments on small animals waiting for imaging an object with three-dimensional optical imaging Fusion.

Description

一种光学多模态成像系统与方法 An optical multi-modality imaging system and method

技术领域 FIELD

[0001] 本发明涉及光学分子成像技术领域,特别是一种光学多模态成像系统与方法。 [0001] The present invention relates to a technical field of optical molecular imaging, in particular to a multi-modality imaging optical system and method.

背景技术 Background technique

[0002] 近年来,随着光学分子影像学技术的飞速发展,一些应用于医学的成像技术,如CT、超声、磁共振、放射性核素成像、正电子发射断层扫描(PET),以及PET/CT等融合成像技术在生命科学及预临床研究中发挥着重要的作用。 [0002] In recent years, with the rapid development of optical molecular imaging techniques, some of the techniques used in medical imaging, such as CT, ultrasound, magnetic resonance imaging, radionuclide imaging, positron emission tomography (PET), and PET / CT fusion imaging and other technologies play an important role in the life science research and pre-clinical in. CT成像分辨率高,没有成像深度限制,能够提供解剖结构信息,但是不能对软组织进行很好的成像。 High-resolution CT imaging, no imaging depth restrictions, anatomical structures can provide information, but can not be a good imaging of soft tissue. 荧光断层成像(FMT)利用光学分子探针,对探针的靶向组织进行生理和病理检测,自发荧光断层成像(BLT)利用生物体自身所发出的荧光进行成像,切伦科夫断层成像(CLT)利用放射性核素在衰变的过程中产生的带电荷的粒子在其介质中的运动速度大于光在该介质中的运动速度时,所产生的切伦科夫光进行成像,但是这些光学成像的方法,成像深度浅,分辨率较低。 Fluorescence tomography (the FMT) an optical molecular probe for targeted tissue physiological and pathological probe detection is performed, BLT (BLT) with fluorescence emitted by the organism itself imaging, tomography Cherenkov ( CLT) using charged particles generated during the radionuclides decay in its velocity is greater than the medium velocity of light in the medium, the Cherenkov light generated by imaging, optical imaging these the method of imaging shallow depth, lower resolution. PET成像具有很好的特异性,并且能够提供功能代谢信息,但是其灵敏度和分辨率较低。 PET imaging with good specificity, and can provide information on metabolic function, but its low sensitivity and resolution. 如何能够将多种模态成像设备融合成像,基于各个模态检测的信息进行融合成像,从而克服单一模态所提供的生理、病理和结构等信息的不足一直是光学分子影像学研究的热点。 Multiple modalities how the image forming apparatus capable of forming a fusion, the fusion image based on the information detected by the respective modalities, thereby overcoming the lack of information physiology, pathology and monomodal structure is provided has been the focus of the optical molecular imaging.

[0003] 国内外有很多研究机构将很多成熟的单模态系统,如CT、PET、FMT以及磁共振(MRI)等进行融合成像,从而获取被测生物体的多种信息。 [0003] There are many domestic and foreign research institutions to many mature single modality systems, such as CT, PET, FMT and a magnetic resonance (MRI) imaging, etc. fusion, so as to acquire a variety of information of the tested organisms. Angelique A等应用FMT/CT融合系统对小鼠颈部和肺部肿瘤进行检测,结果显示,融合了CT信息的FMT结果更为准确。 Angelique A FMT applications / systems CT fusion neck and lung tumors in mice, and the results showed that the fusion of CT FMT result of more accurate information. Li C等构建一种FMT/PET系统,提供了一种FMT和PET双模成像的系统和方法。 Li C et construct a FMT / PET system, a system and method for dual mode imaging and PET FMT. 另外,NahrendorfΜ等人利用商业PET/CT和FMT进行小鼠在体成像,移动放置小鼠的动物仓,依此进行各个模态成像。 Further, NahrendorfΜ et al., The use of commercial PET / CT and FMT imaging member for moving the animals are placed in the cartridge mice mice, each of which carries out imaging modality. 在这种系统和成像方式中,由于小鼠需要移动,势必会造成一些小鼠的姿势和位置变化,对最终成像会造成影响。 In such a system and the imaging mode, since the need to move a mouse, it will inevitably lead to changes in posture and position of a number of mice, will affect the final image. 目前来看,两种模态的系统可以做到同机成像,然而多数三种模态或以上的光学分子成像系统是将小动物在各个模态系统中分别进行成像,然后再将图像进行融合。 Now, two modalities of imaging systems can be done with the machine, but the majority of three kinds or more modal molecular imaging optical system is a small animal imaging modality separately in each system, and then image integration. 上述多模态融合成像的方式,使得小动物等待成像物体的体位在移动过程中产生改变。 Above multimodal fusion imaging mode, waiting position such that the small animal imaged object changes generated during the move. 因此,所获取的图像需要经过算法进行校正,这样既增加了重建图像的时间,而且重建图像的质量也难以得到保证。 Therefore, the acquired image needs to be corrected through the algorithm, so as to enhance the image reconstruction time, and the quality of the reconstructed image is also difficult to be guaranteed.

发明内容 SUMMARY

[0004] 为了解决上述现有技术中存在的问题,本发明提出一种光学多模态成像系统和方法,本发明以通常用于小动物等待成像物体单一模态成像中的CT系统、荧光成像系统和PET成像系统为基本设备,以一种同机融合MRI成像的多模态成像方法为核心,同机采集CT、FMT/BLT/CLT的断层图像、PET图像和MRI图像,并将采集到的二维图像经过图形处理卡进行三维重建,从而获得待成像物体的生理和病理三维融合图像。 [0004] In order to solve the aforementioned problems in the prior art, the present invention provides an optical multi-modality imaging system and method of the present invention is normally used in small animal imaging system object wait CT single modality imaging, fluorescence imaging PET imaging system and a system for the basic equipment, multimodal imaging method in an image fusion MRI imaging core, collect the same plane CT, tomographic image FMT / BLT / CLT is, PET image and the MRI image, and store the collected after the two-dimensional image reconstruction of three-dimensional graphics card, so as to obtain a three-dimensional physiological and pathological fused image object to be imaged.

[0005] 根据本发明的一方面,提出一种光学多模态成像系统,该系统包括:支撑底座、旋转平台、CT系统、荧光成像系统、PET系统、MRI系统、MRI系统支架、直线导轨、待成像物体平台、待成像物体床支架和计算机,其中: [0005] According to an aspect of the present invention provides an optical multi-modality imaging system, the system comprising: a support base, a rotating platform, CT systems, fluorescence imaging system, PET systems, MRI systems, MRI systems holder, linear guide, internet object to be imaged, the bed support and the object to be imaged computer, wherein:

[0006] 所述支撑底座固定于地面; [0006] The support base fixed to the ground;

[0007] 所述旋转平台垂直于地面安装在所述支撑底座的一端,其旋转中心与待成像物体的中心处于同一水平线,所述旋转平台的表面上均匀分布地安装有所述CT系统、荧光成像系统和PET系统,用于按照CT系统和荧光成像系统的成像要求进行旋转; [0007] The rotating platform perpendicular to the ground at one end mounted on said support base, and the center of rotation center of the object to be imaged at the same level, said rotary mounted evenly distributed on the surface of the platform of the CT system, fluorescence PET imaging systems and systems for rotating in claim CT imaging system and a fluorescence imaging system;

[0008] 所述CT系统通过CT专用数据线与所述计算机连接,用于在旋转平台旋转过程中连续不断的采集待成像物体的断层解剖结构图像,并将采集到的断层解剖结构图像传输到所述计算机中进行处理和保存; [0008] The CT CT system via a dedicated data line and the computer, for the tomographic anatomy image capture during the rotation of the rotating platform of the object to be imaged continuously, and the acquired tomographic image is transferred to the anatomy a computer for processing and storage;

[0009] 所述荧光成像系统通过USB或者串行接口数据线与所述计算机连接,用于在旋转平台旋转到固定角度停止后,连续不断的检测待成像物体体内的荧光信号,得到二维荧光图像,并将采集得到的荧光图像传输到所述计算机中进行处理和保存; Fluorescent signal [0009] The fluorescence imaging system via a USB connection or a serial interface cable with the computer, for a fixed angle of rotation to stop after rotating platform, continuous detection of the object to be imaged in vivo, to give a two-dimensional fluorescence image, and transmits the acquired fluorescence image obtained to said computer for processing and storage;

[0010] 所述PET系统通过PET探测器专用数据线与所述计算机连接,用于在旋转平台固定且直线平移台移动PET探测器并形成封闭区域时,连续不断的采集待成像物体的PET图像,并将得到的PET图像传输至所述计算机中进行处理和保存; PET image [0010] The PET PET detector system is connected via a dedicated data line and the computer, for fixing the rotating platform and a linear translation stage moves the PET detectors and form a closed region, the continuous acquisition of the object to be imaged , PET and transmits the obtained image to the computer for processing and storage;

[0011] 所述MRI系统支架垂直于地面安装在支撑底座的一侧,其中心与待成像物体的中心处于同一水平线; [0011] The MRI system bracket mounted perpendicular to the ground side of the support base, the centers of which the object to be imaged at the same level;

[0012] 所述MRI系统与所述计算机连接,安装在所述MRI系统支架上,其成像中心与所述旋转平台的旋转中心处于同一水平线,用于连续不断的采集待成像物体的MRI图像,并将得到的MRI图像传输至所述计算机中进行处理和保存; [0012] The MRI system and the computer is connected, is mounted on the bracket MRI system, and the imaging center of rotation center of the rotating platform are at the same level, for MRI image continuous acquisition object to be imaged, MRI images obtained and transmitted to the computer for processing and storage;

[0013] 所述直线导轨安装在所述支撑底座的上表面上,所述直线导轨上设有通信控制接口,用于连接所述计算机,以根据所述计算机的控制指令进行移动; [0013] The linear guide mounted on the upper surface of the support base of the linear guide provided with a communication control interface for connecting the computer to perform movement control command of the computer;

[0014] 所述待成像物体床支架安装于所述直线导轨上; [0014] The object to be imaged bed bracket mounted on the linear guide;

[0015] 所述待成像物体床固定于所述待成像物体床支架上,用于放置待成像物体; [0015] The object to be imaged is secured to the bed of the object to be imaged on the bed frame, for placing the object to be imaged;

[0016] 所述计算机用于接收所述CT系统、荧光成像系统、PET系统和MRI系统发送的图像并对其进行保存和处理,最终得到待成像物体的三维图像 [0016] The computer for receiving the CT system image, fluorescence imaging system, PET and MRI system of transmission systems and subjected to storage and handling, finally obtained three-dimensional image of the object to be imaged

[0017] 根据本发明的另一方面,还提出一种光学多模态成像方法,该方法包括以下步骤: [0017] According to another aspect of the present invention further provides an optical multi-modality imaging, the method comprising the steps of:

[0018] 步骤1,计算机控制直线平移台移动PET探测器形成一个封闭区域,开始对待成像物体进行PET成像,得到PET图像数据,并将所述PET图像数据传输至所述计算机中进行存储; [0018] Step 1, a computer controlled linear translation stage moves the PET detector to form a closed region, the object to be imaged start PET imaging, PET image data is obtained, and the PET image data to the computer for storage;

[0019] 步骤2,计算机控制直线平移台将PET探测器移开,荧光成像系统开始工作,开启激光器,将激光照射到待成像物体上,CCD相机连续不断地采集待成像物体体内发出的荧光信号,得到二维荧光图像,将所述二维荧光图像传输至所述计算机中进行存储; [0019] Step 2, computer-controlled linear translation stage to remove PET detectors, fluorescence imaging system to work, the laser is turned on, the laser beam is irradiated onto the object to be imaged, the CCD camera continuously collect fluorescence signals emitted from the object to be imaged in vivo , to obtain a two-dimensional fluorescence image, the two-dimensional fluorescence image is transmitted to the computer for storage;

[0020] 步骤3,所述荧光成像系统采集完一幅二维荧光图像后,旋转平台开始旋转,同时CT系统开始连续采集待成像物体的断层解剖结构图像,并将得到的断层解剖结构图像数据传输至所述计算机中进行处理和存储,旋转平台旋转90°后停止; [0020] Step 3, the fluorescence imaging system acquired after completion of a two-dimensional fluorescence image, starts to rotate the rotating platform, while the CT system begins continuous acquisition tomographic image of the anatomy to be imaged object, the tomographic image data and the anatomical structure obtained transmitted to the computer for processing and storage, the 90 ° rotation of the rotary table is stopped;

[0021] 步骤4,重复所述步骤2和步骤3中荧光成像系统和CT系统的图像采集,直到旋转平台旋转360°完成所有二维荧光图像和断层解剖结构图像的采集; [0021] Step 4. Repeat steps 2 and said fluorescent image acquisition system and CT imaging system 3 until the rotation of the rotary platform 360 ° to complete the acquisition of all the two-dimensional fluorescence image and the tomographic image of the anatomical structure;

[0022] 步骤5,计算机控制直线导轨移动待成像物体床,将待成像物体的中心移动到MRI探测器的中心位置,开始对待成像物体进行MRI成像,得到MRI图像数据,并将所述MRI图像数据传输至所述计算机中进行存储; [0022] Step 5, a computer-controlled linear guide bed moving object to be imaged, the center of the object to be imaged is moved to the center position of the MRI probe, began to be imaged objects MRI imaging, MRI image data obtained, and the MRI image data transmission to the computer for storage;

[0023] 步骤6,所述计算机对所有得到的二维图像进行处理,利用二维图像重建待成像物体的三维图像,并对其进行保存。 [0023] Step 6, the computer process all two-dimensional images obtained by the two-dimensional image reconstructed three-dimensional image of the object to be imaged, and save them.

[0024]由于在整个成像过程中,待成像物体始终固定于待成像物体平台之上,多种成像模态对待成像物体各个角度进行断层成像,最后经过图形处理卡对二维图像进行三维重建,多种模态的图像可以将各自的优势互补,克服单一模态的不足,提高图像质量。 [0024] Since the entire imaging process, the object to be imaged is always fixed to the object to be imaged on the internet, a variety of imaging modalities to treat various objects tomography imaging angles, and finally through the graphics card three-dimensional reconstruction of two-dimensional images, multiple modality images can complement their respective strengths to overcome the lack of a single modality, improve image quality. 因此,本发明可用于预临床小动物等待成像物体实验中同机融合MRI的光学分子成像。 Accordingly, the present invention can be used in pre-clinical small animal waiting optical molecular imaging with MRI imaging object Fusion experiments.

附图说明 BRIEF DESCRIPTION

[0025]图1是本发明光学多模态成像系统的结构示意图; [0025] FIG. 1 is a schematic view of an optical multi-modality imaging system according to the present invention;

[0026]图2是本发明光学多模态成像系统的旋转平台的结构正视图; [0026] FIG. 2 is a configuration of the present invention, the rotating platform multimodality imaging optical system of a front view;

[0027]图3是本发明光学多模态成像方法的流程图。 [0027] FIG. 3 is a flowchart of an optical multi-modality imaging method of the present invention.

具体实施方式 Detailed ways

[0028] 为使本发明的目的、技术方案和优点更加清楚明白,以下结合具体实施例,并参照附图,对本发明进一步详细说明。 [0028] To make the objectives, technical solutions, and advantages of the present invention will become more apparent hereinafter in conjunction with specific embodiments, and with reference to the accompanying drawings, the present invention is described in further detail.

[0029]图1是本发明光学多模态成像系统的结构示意图,如图1所示,所述光学多模态成像系统包括:MRI系统1、待成像物体平台3、待成像物体平台支架4、直线导轨5、旋转平台6、CT系统、荧光成像系统、MRI系统支架10、PET系统、支撑底座11和计算机,其中: [0029] FIG. 1 is a schematic view of an optical multi-modality imaging system according to the present invention, shown in Figure 1, the multi-modality imaging optical system comprising: MRI system 1, the object to be imaged platform 3, the object to be imaged internet holder 4 , linear guide 5, the rotating platform 6, CT systems, fluorescence imaging system, MRI system holder 10, PET systems, the support base 11 and a computer, wherein:

[0030] 所述支撑底座11固定于地面; [0030] The support base 11 is fixed to the ground;

[0031] 所述旋转平台6垂直于地面安装在所述支撑底座11的一端,其旋转中心与待成像物体的中心处于同一水平线,所述旋转平台6的表面上均匀分布地安装有所述CT系统、荧光成像系统和PET系统,用于按照CT系统和荧光成像系统的成像要求进行旋转; [0031] The rotating platform 6 is mounted perpendicular to the ground at one end of the support base 11, and the center of rotation center of the object to be imaged at the same level, distributed uniformly over the surface of the rotating platform 6 is attached to the CT systems, and PET systems fluorescence imaging system, for rotating in claim CT imaging system and a fluorescence imaging system;

[0032] 所述MRI系统支架10垂直于地面安装在支撑底座11的一侧,其中心与待成像物体的中心处于同一水平线,所述MRI系统支架10上安装有所述MRI系统1 ; [0032] The MRI system bracket 10 is mounted perpendicular to the ground side of the support base 11, the center of which is the center of the object to be imaged at the same level, the MRI system 1 is mounted on the bracket 10 of the MRI system;

[0033] 所述MRI系统1与所述计算机连接,其成像中心与所述旋转平台6的旋转中心处于同一水平线,用于连续不断的采集待成像物体的MRI图像,并将得到的MRI图像传输至所述计算机中进行处理和保存; [0033] The MRI system 1 is connected to the computer, and the imaging center and the rotational center of the rotating platform 6 at the same level, for MRI image continuous acquisition object to be imaged, and the resulting MRI image transfer to the computer for processing and storage;

[0034] 所述MRI系统1包括主磁体8和射频线圈2,所述主磁体8提供用于成像的磁场,射频线圈2提供用于成像的脉冲序列; [0034] The MRI system includes a main magnet 1 and the RF coil 8 2, 8 of the main magnet provides a magnetic field for imaging, the radio frequency coil 2 to provide a pulse sequence for imaging;

[0035] 所述直线导轨5安装在所述支撑底座11的上表面上,用于移动安装在其上的待成像物体平台支架4,所述直线导轨5上设有通信控制接口,用于连接所述计算机,以根据所述计算机的控制指令进行移动; [0035] The linear guide 5 is mounted on an upper surface of the support base 11, to be imaged for moving the mounting platform on which the object holder 4, the communication control interface provided on the linear guide 5, for connecting the computer, in accordance with a control command to move to the computer;

[0036] 所述待成像物体平台支架4安装于所述直线导轨上; [0036] The object to be imaged internet bracket 4 mounted on the upper linear guide;

[0037] 所述待成像物体平台3固定于所述待成像物体平台支架4上,用于放置待成像物体; [0037] The platform 3 is fixed to the object to be imaged to the object to be imaged internet holder 4 for placing the object to be imaged;

[0038] 所述多个直线平移台24安装于旋转平台6上,并且呈正交布置,用于承载CT系统、荧光成像系统和PET系统,所述直线平移台24上设有通信控制接口,与所述计算机连接,以根据所述计算机的控制指令进行移动; [0038] The plurality of linear translation stage 24 is mounted on a rotating platform 6, and is in orthogonal arrangement for carrying CT system, a PET system and a fluorescence imaging system, the linear translation communication control interface provided on the table 24, connected to the computer, to perform movement control command of the computer;

[0039] 所述CT系统通过CT专用数据线与所述计算机连接,用于在旋转平台6旋转过程中连续不断的采集待成像物体的断层解剖结构图像,并将采集到的断层解剖结构图像传输到所述计算机中进行处理和保存; [0039] The CT CT system via a dedicated data line and the computer, for a tomographic image anatomy rotating platform 6 rotates continuously during acquisition of the object to be imaged, and the acquired tomographic image transmission anatomy processed and saved to the computer;

[0040] 所述CT系统包括X射线管23和X射线探测器7,其中,X射线管23与X射线探测器7相对安装在所述旋转平台6上,所述X射线管23的射线口、待成像物体中心及X射线探测器7的中心位置处于同一条直线上,以保证CT图像质量; [0040] The CT system includes an X-ray tube 23 and X-ray detector 7, wherein, the X-ray tube 23 relative to the X-ray detector 7 is mounted on the rotating platform 6, the X-ray tube 23 opening ray , the center of the object to be imaged and the center position of the X-ray detector 7 is in the same line, in order to ensure the quality of CT images;

[0041] 所述荧光成像系统通过USB或者串行接口数据线与所述计算机连接,用于在旋转平台6旋转到固定角度停止后,连续不断的检测待成像物体体内的荧光信号,得到二维荧光图像,并将采集得到的荧光图像传输到所述计算机中进行处理和保存; [0041] The fluorescence imaging system via a USB or serial interface cable connected with the computer, the fluorescent signal for the rotating platform 6 to the fixed angle of rotation is stopped, continuous detection of the object to be imaged in vivo, to give a two-dimensional fluorescence image acquisition and transmission fluorescence images obtained to said computer for processing and storage;

[0042] 所述荧光成像系统包括激光器9和C⑶相机21,其中,激光器9与(XD相机21相对安装于旋转平台6上,所述CCD相机21的成像视野需要能完全包括待成像物体全身,激光器9发出的激光照射到待成像物体上,待成像物体体内产生激发荧光,此时CCD相机21连续检测待成像物体体内的荧光信号,形成一幅二维荧光图像,并传输到所述计算机中; [0042] The fluorescence imaging system includes a laser C⑶ camera 9 and 21, wherein the laser 9 (XD mounted on the camera 21 relative to the rotating platform 6, the CCD camera 21 of the imaging field of view required to fully object to be imaged comprises a body, 9 emitted from the laser irradiating a laser onto the object to be imaged, the object to be imaged in vivo to produce fluorescence excitation, the CCD camera 21 at this time continuous fluorescent signal in vivo detection of the object to be imaged, forming a two-dimensional fluorescence image, and transmitted to the computer ;

[0043] 所述PET系统通过PET探测器专用数据线与所述计算机连接,用于在旋转平台6固定且直线平移台24移动PET探测器22并形成封闭区域时,连续不断的采集待成像物体的PET图像,并将得到的PET图像传输至所述计算机中进行处理和保存; [0043] The PET PET detector system is connected via a dedicated data line and the computer, for a fixed and a linear translation stage 24 is moved PET detector 22 and a closed region is formed when the rotating platform 6, continuous acquisition object to be imaged PET PET image image transfer, and the resultant to the computer for processing and storage;

[0044] 所述PET系统包括多个PET探测器22,所述PET探测器22的数量为偶数对,并且不少于四组,所述PET探测器22安装于直线平移台24上,待成像物体体内注射放射性同位素后放射出伽马光子,通过直线平移台24移动PET探测器22并形成封闭区域,PET探测器22检测由待成像物体体内发出的伽马光子,经过光电转换后获取PET图像,并将所获得的PET图像传输至所述计算机中; [0044] The PET system 22 includes a plurality of PET detectors, the number of the PET detector 22 is an even number pairs, and no less than four, the PET detector 22 is mounted on a linear translation stage 24, to be imaged objects in vivo injection of gamma photons emitted from a radioisotope, a linear translation stage 24 is moved by the PET detector 22 and form a closed region, the PET detector 22 detects the gamma photons emitted by the object to be imaged, acquires a PET image after photoelectric conversion , PET and transmits the obtained image to the computer;

[0045] 所述计算机安装有图形处理卡并能够支撑图形并行计算,所述图形处理卡与直线平移台24、CT系统、荧光成像系统、PET系统和MRI系统相连,用于连续不断地采集各个成像系统得到的图像,并对采集得到的图像进行处理,比如位置配准,图像融合等,并将处理后的二维图像重建为三维图像,即所述计算机接收所述CT系统、荧光成像系统、PET系统和MRI系统发送的图像并对其进行保存和处理,最终得到待成像物体的三维图像; [0045] The computer graphics card is installed and is capable of supporting parallel computing graphics, the graphics card and a linear translation stage 24, is connected to the CT system, a fluorescent imaging system, PET and MRI system system for continuously collecting the respective the imaging system to obtain an image, and the obtained image acquisition processing, such as location registration, image fusion, the two-dimensional image and the three-dimensional reconstruction of the processed image, i.e. the computer to receive the CT system, a fluorescence imaging system , PET images and the MRI system transmission system and its storage and handling, finally obtained three-dimensional image of the object to be imaged;

[0046] 所述计算机上还装有用于连接直线导轨5和直线平移台24的通讯控制接口,该接口可以是USB接口或者串行接口,这些接口通过USB线或者串行线与直线导轨5和直线平移台24相连,可以从直线导轨5和直线平移台24读取其运动参数,比如位置和速度参数,并将获得的参数返回所述计算机,所述计算机根据获得的参数发出控制指令,控制直线导轨5和直线平移台24移动。 [0046] The computer is also mounted on a linear guide connected to a linear translation stage 5 and the communication control interface 24, the interface may be a USB interface or serial interfaces, these interfaces via a USB cable or a serial line, and the linear guide 5 is connected to a linear translation stage 24, may be translated from the linear guide 5 and the linear stage 24 reads the motion parameters, such as position and speed parameters, and the computer returns the obtained parameters, the computer sends a control instruction according to the obtained parameters, control linear guides 5 and a linear translation stage 24 moves.

[0047]图3是本发明光学多模态成像方法的流程图,如图3所示,所述多模态成像方法包括以下步骤: [0047] FIG. 3 is a flowchart of an optical multi-modality imaging method of the invention, shown in Figure 3, the multi-modality imaging method comprising the steps of:

[0048] 步骤1,计算机控制直线平移台移动PET探测器形成一个封闭区域,开始对待成像物体进行PET成像,得到PET图像数据,并将所述PET图像数据传输至所述计算机中进行存储; [0048] Step 1, a computer controlled linear translation stage moves the PET detector to form a closed region, the object to be imaged start PET imaging, PET image data is obtained, and the PET image data to the computer for storage;

[0049] 步骤2,计算机控制直线平移台将PET探测器移开,荧光成像系统开始工作,开启激光器,将激光照射到待成像物体上,CCD相机连续不断地采集待成像物体体内发出的荧光信号,得到二维荧光图像,将所述二维荧光图像传输至所述计算机中进行存储; [0049] Step 2, computer-controlled linear translation stage to remove PET detectors, fluorescence imaging system to work, the laser is turned on, the laser beam is irradiated onto the object to be imaged, the CCD camera continuously collect fluorescence signals emitted from the object to be imaged in vivo , to obtain a two-dimensional fluorescence image, the two-dimensional fluorescence image is transmitted to the computer for storage;

[0050] 步骤3,所述荧光成像系统采集完一幅二维荧光图像后,旋转平台开始旋转,同时CT系统开始连续采集待成像物体的断层解剖结构图像,并将得到的断层解剖结构图像数据传输至所述计算机中进行处理和存储,旋转平台旋转90°后停止; [0050] Step 3, the fluorescence imaging system acquired after completion of a two-dimensional fluorescence image, starts to rotate the rotating platform, while the CT system begins continuous acquisition tomographic image of the anatomy to be imaged object, the tomographic image data and the anatomical structure obtained transmitted to the computer for processing and storage, the 90 ° rotation of the rotary table is stopped;

[0051] 步骤4,重复所述步骤2和步骤3中荧光成像系统和CT系统的图像采集,直到旋转平台旋转360°完成所有二维荧光图像和断层解剖结构图像的采集; [0051] Step 4. Repeat steps 2 and said fluorescent image acquisition system and CT imaging system 3 until the rotation of the rotary platform 360 ° to complete the acquisition of all the two-dimensional fluorescence image and the tomographic image of the anatomical structure;

[0052] 步骤5,计算机控制直线导轨移动待成像物体平台,将待成像物体的中心移动到MRI探测器的中心位置,开始对待成像物体进行MRI成像,得到MRI图像数据,并将所述MRI图像数据传输至所述计算机中进行存储; [0052] Step 5, a computer-controlled linear guide platform moving object to be imaged, the center of the object to be imaged is moved to the center position of the MRI probe, began to be imaged objects MRI imaging, MRI image data obtained, and the MRI image data transmission to the computer for storage;

[0053] 步骤6,所述计算机对所有得到的二维图像进行处理,利用二维图像重建待成像物体的三维图像,并对其进行保存,至此完成多模态图像采集和重建,结束,其中,所述处理包括但不限于位置配准,图像融合等图像处理。 [0053] Step 6, the computer for all processing of two-dimensional images obtained by the two-dimensional image reconstructed three-dimensional image of the object to be imaged, and subjected to save, thereby completing a multi-modality image acquisition and reconstruction end, wherein said processing including but not limited to the location registration, image processing such as image fusion.

[0054] 其中,MRI系统的图像采集可以在其他模态的成像系统采集之前也可以在其他模态的成像系统采集结束后进行。 [0054] wherein the image acquisition of the MRI system may also be carried out after the other modality imaging system acquired before any other modality imaging system acquisition.

[0055] 以上所述的具体实施例,对本发明的目的、技术方案和有益效果进行了进一步详细说明,所应理解的是,以上所述仅为本发明的具体实施例而已,并不用于限制本发明,凡在本发明的精神和原则之内,所做的任何修改、等同替换、改进等,均应包含在本发明的保护范围之内。 Specific Example [0055] above, the objectives, technical solutions, and beneficial effects of the present invention will be further described in detail, it should be understood that the above descriptions are merely embodiments of the present invention, but not intended to limit the present invention, within the spirit and principle of the present invention, any modifications, equivalent replacements, improvements, etc., should be included within the scope of the present invention.

Claims (7)

1.一种光学多模态成像系统,其特征在于,该系统包括:支撑底座、旋转平台、CT系统、荧光成像系统、PET系统、MRI系统、MRI系统支架、直线导轨、待成像物体平台、待成像物体平台支架和计算机,其中: 所述支撑底座固定于地面; 所述旋转平台垂直于地面安装在所述支撑底座的一端,其旋转中心与待成像物体的中心处于同一水平线,所述旋转平台的表面上均匀分布地安装有所述CT系统、荧光成像系统和PET系统,用于按照CT系统和荧光成像系统的成像要求进行旋转; 所述CT系统通过CT专用数据线与所述计算机连接,用于在旋转平台旋转过程中连续不断的采集待成像物体的断层解剖结构图像,并将采集到的断层解剖结构图像传输到所述计算机中进行处理和保存; 所述荧光成像系统通过USB或者串行接口数据线与所述计算机连接,用于在旋转平台旋转到固定 An optical multi-modality imaging system, wherein the system comprises: a support base, a rotating platform, CT systems, fluorescence imaging system, PET systems, MRI systems, MRI systems holder, linear guide, the object to be imaged platform, object to be imaged and a computer platform brackets, wherein: said support base fixed to the ground; a rotary platform mounted perpendicular to the ground one end of the support base, the center of the center of rotation of the object to be imaged at the same level, the rotation uniformly distributed on the surface of the platform is mounted the CT system, a PET system and a fluorescence imaging system, for rotating in claim CT imaging system and a fluorescence imaging system; the CT CT system via a dedicated data line and the computer collected in a rotating platform for continuous rotation during the tomographic image of the anatomy of the object to be imaged, and the acquired tomographic image is transmitted to the anatomy computer for processing and storage; fluorescence imaging system via the USB or serial interface with the computer connected to the data lines, for rotating the rotating platform to a stationary 度停止后,连续不断的检测待成像物体体内的荧光信号,得到二维荧光图像,并将采集得到的荧光图像传输到所述计算机中进行处理和保存; 所述PET系统通过PET探测器专用数据线与所述计算机连接,用于在旋转平台固定且直线平移台移动PET探测器并形成封闭区域时,连续不断的采集待成像物体的PET图像,并将得到的PET图像传输至所述计算机中进行处理和保存; 所述MRI系统支架垂直于地面安装在支撑底座的一侧,其中心与待成像物体的中心处于同一水平线; 所述MRI系统与所述计算机连接,安装在所述MRI系统支架上,其成像中心与所述旋转平台的旋转中心处于同一水平线,用于连续不断的采集待成像物体的MRI图像,并将得到的MRI图像传输至所述计算机中进行处理和保存; 所述直线导轨安装在所述支撑底座的上表面上,所述直线导轨上设有通信控制 After the stop of, the continuous detection of the object to be imaged in vivo fluorescent signal to obtain a two-dimensional fluorescence image, the fluorescence image acquisition and transfer to the obtained computer for processing and storage; PET detector by the PET system-specific data line and the computer connected to the internet PET image in a fixed rotational movement and the linear translation stage PET detector and form a closed region, the continuous acquisition of the object to be imaged, and the resulting PET image transmission to the computer processing and storage; the MRI system is perpendicular to the ground bracket mounted on one side of the support base, the center of which is the center of the object to be imaged at the same level; the MRI system and the computer is connected, is installed in the MRI system bracket on its rotation center of the imaging center of rotation of the platform at the same level, for MRI image continuous acquisition object to be imaged, and the resulting MRI image transmission to the computer for processing and storage; the straight line rails mounted on the upper surface of the support base, provided with a communication control said linear guide 口,用于连接所述计算机,以根据所述计算机的控制指令进行移动; 所述待成像物体平台支架安装于所述直线导轨上; 所述待成像物体平台固定于所述待成像物体平台支架上,用于放置待成像物体; 所述计算机用于接收所述CT系统、荧光成像系统、PET系统和MRI系统发送的图像并对其进行保存和处理,最终得到待成像物体的三维图像; 所述PET系统包括多个PET探测器,所述PET探测器安装于直线平移台上,待成像物体体内注射放射性同位素后放射出伽马光子,通过直线平移台移动PET探测器并形成封闭区域,PET探测器检测由待成像物体体内发出的伽马光子,经过光电转换后获取PET图像,所述PET探测器的数量为偶数对,并且不少于四组,其中,所述多个直线平移台安装于旋转平台上,并且呈正交布置,用于承载CT系统、荧光成像系统和PET系统。 Port for connecting the computer to perform movement control command of the computer; the object to be imaged is mounted on said bracket platform linear guide; the object to be imaged is secured to the platform deck carriers object to be imaged on, for placing the object to be imaged; said computer for receiving the CT system image, a fluorescent imaging system, PET and MRI system of transmission systems and subjected to storage and handling, finally obtained three-dimensional image of the object to be imaged; the said system comprising a plurality of PET PET detector, the PET detectors mounted on a linear translation stage, the object to be imaged in vivo injection of a radioactive isotope emits gamma photons, by a linear translation stage and moved PET detector to form a closed region, PET probe detects gamma photons emitted by the object to be imaged in vivo, the PET image acquired after photoelectric conversion, the number is even the PET detector pair, and not less than four, wherein said plurality of linear translation stage is mounted on a rotating platform, and it is in orthogonal arrangement for carrying CT system, a PET system, and a fluorescence imaging system.
2.根据权利要求1所述的系统,其特征在于,所述MRI系统包括主磁体和射频线圈,所述主磁体提供用于成像的磁场,射频线圈提供用于成像的脉冲序列。 2. The system according to claim 1, wherein the MRI system includes a main magnet and RF coil, the main magnet provides a magnetic field for imaging, the radio frequency coil to provide a pulse sequence for imaging.
3.根据权利要求1所述的系统,其特征在于,所述旋转平台上安装有:CCD相机、激光器、PET探测器、X射线管、X射线探测器和多个直线平移台。 3. The system of claim 1, wherein said rotating platform is attached: CCD camera, laser, PET detectors, X-ray tube, X-ray detector and a plurality of linear translation stage.
4.根据权利要求3所述的系统,其特征在于,所述直线平移台上设有通信控制接口,与所述计算机连接,以根据所述计算机的控制指令进行移动。 4. The system of claim 3, wherein said linear translation stage has a communication control interface connected to the computer, according to the control command to the mobile computer.
5.根据权利要求3所述的系统,其特征在于,所述CT系统包括X射线管和X射线探测器,其中,X射线管与X射线探测器相对安装在所述旋转平台上,所述X射线管的射线口、待成像物体中心及X射线探测器的中心位置处于同一条直线上。 5. The system according to claim 3, wherein said CT system comprising an X-ray tube and the X-ray detector, wherein, the X-ray tube and the X-ray detector mounted on the opposite rotating platform, the ray X-ray tube opening, the center position of the center of the object to be imaged and the X-ray detector is on the same line.
6.根据权利要求3所述的系统,其特征在于,所述荧光成像系统包括激光器和CCD相机,其中,激光器与CCD相机相对安装于旋转平台上,所述CCD相机的成像视野完全包括待成像物体全身,激光器发出的激光照射到待成像物体上,待成像物体体内产生激发荧光,CCD相机连续检测待成像物体体内的荧光信号,形成一幅二维荧光图像。 6. The system according to claim 3, wherein said fluorescence imaging system includes a laser and a CCD camera, wherein the laser and CCD camera mounted on a rotating platform relative to, the imaging field of view fully encompasses the CCD camera to be imaged object body, laser light emitted from the laser irradiation to the object to be imaged, the object to be imaged in vivo to produce fluorescence excitation, the fluorescent signal of the CCD camera continuously detected object to be imaged in vivo, forming a two-dimensional fluoroscopic image.
7.根据权利要求3所述的系统,其特征在于,所述计算机通过通讯控制接口与直线导轨和直线平移台相连,读取其运动参数,所述计算机根据获得的运动参数发出控制指令,控制直线导轨和直线平移台移动。 7. The system according to claim 3, wherein said control computer through the communication interface translating linear guide table and connected to a straight line, which reads the motion parameters, the computer sends a control command in accordance with the obtained motion parameters, control linear guide and a linear translation stage moves.
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