CN104491745B - A kind of Chinese medicine for treating Bones and joints and soft tissue injury and its application - Google Patents

A kind of Chinese medicine for treating Bones and joints and soft tissue injury and its application Download PDF

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CN104491745B
CN104491745B CN201510003740.5A CN201510003740A CN104491745B CN 104491745 B CN104491745 B CN 104491745B CN 201510003740 A CN201510003740 A CN 201510003740A CN 104491745 B CN104491745 B CN 104491745B
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parts
root
chinese
chinese medicine
soft tissue
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CN104491745A (en
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方凡夫
李柏
顾伟
黄枫
周菲
黄婧慧
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Second Military Medical University SMMU
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    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/716Clematis (leather flower)
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Abstract

Bones and joints and the Chinese medicine of soft tissue injury are treated the present invention relates to a kind of, described Chinese medicine is mainly made up of following bulk drug:The root of Chinese clematis, the rhizome of davallia, caulis piperis futokadsurae, root tuber of aromatic turmeric, lycopodium calvatum, the root of kudzu vine, teasel root, paniculate swallowwort, Chinese ephedra, windproof, cassia twig, Canton love-pea vine, root of Chinese trichosanthes, semen brassicae, safflower, golden cypress, Ligusticum wallichii, Radix Angelicae Sinensis, the dried rhizome of rehmannia.The present invention also provides the application of the Chinese medicine.Its advantage is shown:There is the Chinese medicine of the present invention obvious swelling and pain relieving to act on, and functional rehabilitation is fast, easy to use, meets traditional Chinese medical theory, and clinical efficacy is notable, has no adverse reaction, and should be widely promoted.

Description

A kind of Chinese medicine for treating Bones and joints and soft tissue injury and its application
Technical field
It is a kind of Chinese medicine for treating Bones and joints and soft tissue injury and its should specifically the present invention relates to technical field With.
Background technology
With mechanical industry, transportation and construction industry developing rapidly in modern society, wound turns into harm One big public hazards of public health, degree of injury become weight, complicated, dead, disability rate substantially increase.Osteoarticular injury be it is a kind of more Serious wound, it is caused by powerful external force more, it has also become one of urban population lethal the main reason for disabling.
Soft tissue injury refers to the damage of the kinematic system tissue such as skeletal muscle, manadesma, ligament, capsular ligament, periosteum, adipose tissue Wound.Belong to motherland's medical science " injury of tendon and muscle " category, it is fallen ill extensively, is one of most commonly seen illness of orthopedics and traumatology, drastically influence people Production and living quality.
Chinese patent literature CN102861196A discloses a kind of Chinese medicine for treating osteoarticular injury, by weight percentage by Following composition composition:Frankincense 10-35g, myrrh 10-30g, cassia twig 10-30g, rattletop 5-35g, dipsacus root 5-25g, rheum officinale 5-20g, West safflower 10-35g, brave amber 5-35g, Radix Angelicae Sinensis 5-30g, catechu 5-35g, even call 5-35g together, be pseudo-ginseng 10-35g, Chinese ephedra 5-30g, white Root of Dahurian angelica 10-35g, eupolyphage sece steleophaga 10-40g, dragon's blood 8-25g, white giant 10-35g, native copper 10-35g.Chinese patent literature CN200410004741.3 disclose the invention discloses a kind of set a broken bone, soft tissue bruise disease Chinese medicine composition, the group The main dragon's blood of compound, lucid realgar, safflower, catechu, cinnabar, frankincense, Radix Angelicae Sinensis tail, myrrh, borneol, Moschus, native copper, ground beetle, The bulk drugs such as the rhizome of davallia, monkshood, pseudo-ginseng form.Chinese patent literature CN104027691A discloses one kind and treats soft tissue injury Traditional Chinese herbal decoction, the parts by weight of its constitutive material are:Radix Angelicae Sinensis 6-10, corydalis tuber 5-8, myrrh 4-6, rhizome of davallia 6-8, Ligusticum wallichii 3-5, Kaempferia galanga 4-7, root bark of white mulberry 3-6, Soil unit 2-3, Herba Lycopi 4-7, root of Dahurain angelica 5-7, radix scutellariae 2-3, west safflower 3-5, cloves 6-8, eupolyphoge sinensis 2-3, RADIX CODONOPSIS PILOSULAE from Northwest of China 4-8, profound Hu 3-5, Fructus Aurantii 3-6, dandelion 2-4, borneol 5-7, berchemia lineata 4-6, daghestan sweetclover root 3-7, Root of Divaricate Houndstongue 5-8 With Bermuda grass 3-5.But the Chinese medicine of the treatment Bones and joints and soft tissue injury on the present invention and its application yet there are no report Road.
The content of the invention
The purpose of the present invention is to be directed to deficiency of the prior art, there is provided a kind of to treat in Bones and joints and soft tissue injury Medicine.
Another purpose of the present invention is to provide a kind of application for treating Bones and joints and the Chinese medicine of soft tissue injury.
To achieve the above object, the present invention adopts the technical scheme that:It is a kind of to treat in Bones and joints and soft tissue injury Medicine, described Chinese medicine are mainly made up of the bulk drug of following parts by weight:Root of Chinese clematis 8-16 parts, rhizome of davallia 8-16 parts, caulis piperis futokadsurae 8- 16 parts, it is root tuber of aromatic turmeric 7-13 parts, lycopodium calvatum 8-16 parts, root of kudzu vine 7-13 parts, teasel root 7-13 parts, paniculate swallowwort 7-13 parts, Chinese ephedra 3-7 parts, anti- Wind 7-13 parts, cassia twig 4-8 parts, Canton love-pea vine 7-13 parts, root of Chinese trichosanthes 7-13 parts, semen brassicae 6-10 parts, safflower 3-7 parts, golden cypress 7-13 Part, Ligusticum wallichii 4-8 parts, Radix Angelicae Sinensis 8-16 parts, dried rhizome of rehmannia 7-13 parts.
Described Chinese medicine is mainly made up of the bulk drug of following parts by weight:Root of Chinese clematis 10-14 parts, rhizome of davallia 10-14 parts, sea Wind rattan 10-14 parts, root tuber of aromatic turmeric 8-12 parts, lycopodium calvatum 10-14 parts, root of kudzu vine 8-12 parts, teasel root 8-12 parts, paniculate swallowwort 8-12 parts, Chinese ephedra 4-6 parts, windproof 8-12 parts, cassia twig 5-7 parts, Canton love-pea vine 8-12 parts, root of Chinese trichosanthes 8-12 parts, semen brassicae 7-9 parts, safflower 4-6 parts, Huang Cypress 8-12 parts, Ligusticum wallichii 5-7 parts, Radix Angelicae Sinensis 10-14 parts, dried rhizome of rehmannia 8-12 parts.
Described Chinese medicine is mainly made up of the bulk drug of following parts by weight:12 parts of the root of Chinese clematis, 12 parts of the rhizome of davallia, caulis piperis futokadsurae 12 Part, 10 parts of root tuber of aromatic turmeric, 12 parts of lycopodium calvatum, 10 parts of the root of kudzu vine, 10 parts of teasel root, 10 parts of paniculate swallowwort, 5 parts of Chinese ephedra, windproof 10 parts, 6 parts of cassia twig, 10 parts of Canton love-pea vine, 10 parts of root of Chinese trichosanthes, 8 parts of semen brassicae, 5 parts of safflower, 10 parts of golden cypress, 6 parts of Ligusticum wallichii, 12 parts of Radix Angelicae Sinensis, 10 parts of the dried rhizome of rehmannia.
To realize above-mentioned second purpose, the present invention adopts the technical scheme that:Described Chinese medicine is preparing treatment bone pass Save the application in the medicine of damage.
Application of the described Chinese medicine in the medicine for preparing treatment soft tissue injury.
Described pharmaceutical dosage form be tincture, spirit, pulvis, lotion, finish, emulsion, ointment, paste, plaster, plastics, Gel, aerosol or Babu cream.
The invention has the advantages that:
There is the Chinese medicine of the present invention obvious swelling and pain relieving to act on, and functional rehabilitation is fast, easy to use, meets traditional Chinese medical science pharmacology By clinical efficacy is notable, has no adverse reaction, and should be widely promoted.
Embodiment
Embodiment provided by the invention is elaborated with reference to embodiment.
A kind of to treat Bones and joints and the Chinese medicine of soft tissue injury, described Chinese medicine is mainly by the bulk drug system of following parts by weight Into:Root of Chinese clematis 8-16 parts, rhizome of davallia 8-16 parts, caulis piperis futokadsurae 8-16 parts, root tuber of aromatic turmeric 7-13 parts, lycopodium calvatum 8-16 parts, root of kudzu vine 7-13 parts, Teasel root 7-13 parts, paniculate swallowwort 7-13 parts, Chinese ephedra 3-7 parts, windproof 7-13 parts, cassia twig 4-8 parts, Canton love-pea vine 7-13 parts, root of Chinese trichosanthes 7- 13 parts, semen brassicae 6-10 parts, safflower 3-7 parts, golden cypress 7-13 parts, Ligusticum wallichii 4-8 parts, Radix Angelicae Sinensis 8-16 parts, dried rhizome of rehmannia 7-13 parts.It is preferred that Ground, root of Chinese clematis 10-14 parts, rhizome of davallia 10-14 parts, caulis piperis futokadsurae 10-14 parts, root tuber of aromatic turmeric 8-12 parts, lycopodium calvatum 10-14 parts, root of kudzu vine 8- 12 parts, teasel root 8-12 parts, paniculate swallowwort 8-12 parts, Chinese ephedra 4-6 parts, windproof 8-12 parts, cassia twig 5-7 parts, Canton love-pea vine 8-12 parts, smallpox Powder 8-12 parts, semen brassicae 7-9 parts, safflower 4-6 parts, golden cypress 8-12 parts, Ligusticum wallichii 5-7 parts, Radix Angelicae Sinensis 10-14 parts, dried rhizome of rehmannia 8-12 parts.
The Chinese medicine of embodiment 1
12 parts of the root of Chinese clematis, 12 parts of the rhizome of davallia, 12 parts of caulis piperis futokadsurae, 10 parts of root tuber of aromatic turmeric, 12 parts of lycopodium calvatum, 10 parts of the root of kudzu vine, teasel root 10 Part, 10 parts of paniculate swallowwort, 5 parts of Chinese ephedra, windproof 10 parts, 6 parts of cassia twig, 10 parts of Canton love-pea vine, 10 parts of root of Chinese trichosanthes, 8 parts of semen brassicae, safflower 5 Part, 10 parts of golden cypress, 6 parts of Ligusticum wallichii, 12 parts of Radix Angelicae Sinensis, 10 parts of the dried rhizome of rehmannia.
The Chinese medicine of embodiment 2
10 parts of the root of Chinese clematis, 14 parts of the rhizome of davallia, 10 parts of caulis piperis futokadsurae, 12 parts of root tuber of aromatic turmeric, 10 parts of lycopodium calvatum, 12 parts of the root of kudzu vine, teasel root 8 Part, 12 parts of paniculate swallowwort, 4 parts of Chinese ephedra, windproof 12 parts, 5 parts of cassia twig, 12 parts of Canton love-pea vine, 8 parts of root of Chinese trichosanthes, 9 parts of semen brassicae, safflower 4 Part, 12 parts of golden cypress, 5 parts of Ligusticum wallichii, 14 parts of Radix Angelicae Sinensis, 8 parts of the dried rhizome of rehmannia.
The Chinese medicine of embodiment 3
14 parts of the root of Chinese clematis, 10 parts of the rhizome of davallia, 14 parts of caulis piperis futokadsurae, 8 parts of root tuber of aromatic turmeric, 14 parts of lycopodium calvatum, 8 parts of the root of kudzu vine, 12 parts of teasel root, 8 parts of paniculate swallowwort, 6 parts of Chinese ephedra, windproof 8 parts, 7 parts of cassia twig, 8 parts of Canton love-pea vine, 12 parts of root of Chinese trichosanthes, 7 parts of semen brassicae, 6 parts of safflower, golden cypress 8 parts, 7 parts of Ligusticum wallichii, 10 parts of Radix Angelicae Sinensis, 12 parts of the dried rhizome of rehmannia.
The Chinese medicine of embodiment 4
8 parts of the root of Chinese clematis, 16 parts of the rhizome of davallia, 8 parts of caulis piperis futokadsurae, 13 parts of root tuber of aromatic turmeric, 8 parts of lycopodium calvatum, 13 parts of the root of kudzu vine, 7 parts of teasel root, Xu Long 13 parts of minister in ancient times, 3 parts of Chinese ephedra, windproof 13 parts, 4 parts of cassia twig, 13 parts of Canton love-pea vine, 7 parts of root of Chinese trichosanthes, 10 parts of semen brassicae, 3 parts of safflower, Huang 13 parts of cypress, 4 parts of Ligusticum wallichii, 16 parts of Radix Angelicae Sinensis, 7 parts of the dried rhizome of rehmannia.
The Chinese medicine of embodiment 5
16 parts of the root of Chinese clematis, 8 parts of the rhizome of davallia, 16 parts of caulis piperis futokadsurae, 7 parts of root tuber of aromatic turmeric, 16 parts of lycopodium calvatum, 7 parts of the root of kudzu vine, 13 parts of teasel root, 7 parts of paniculate swallowwort, 7 parts of Chinese ephedra, windproof 7 parts, 8 parts of cassia twig, 7 parts of Canton love-pea vine, 13 parts of root of Chinese trichosanthes, 6 parts of semen brassicae, 7 parts of safflower, golden cypress 7 parts, 8 parts of Ligusticum wallichii, 8 parts of Radix Angelicae Sinensis, 13 parts of the dried rhizome of rehmannia.
The preparation of the Chinese medicine of embodiment 6
The pharmaceutical dosage form that any described Chinese medicines of embodiment 1-5 are prepared by conventional formulation means, for example, tincture, spirit, Pulvis, lotion, finish, emulsion, ointment, paste, plaster, plastics, gel, aerosol or Babu cream etc..
The clinical test of embodiment 7
1 clinical data
1.1 research object
Bones and joints and soft tissue injury patient come from Changhai hospital Emergency call, according to《Traditional Chinese traumatology》Formulate diagnostic criteria With treatment standard.
1.2 primary symptom criterions
Pain:Slightly, there is sensation of pain, do not influence routine work and activity;Moderate, sensation that pain acid is swollen, can adhere to day Often work and life;Severe, sharp ache, it is difficult to endure, influence routine work and life.Swelling:Slightly, the colour of skin changes, and swells Swollen degree is higher than normal skin 1mm-3mm;Moderate, the colour of skin change, and swelling degree is higher than between normal skin 4mm~6mm;Weight Degree, the colour of skin changes, smooth bright or livid purple visible.Swelling degree is higher than normal skin 5mm-10mm.Functional activity scope:It is good (+), more than the 1/2 of normal range (NR);In (++), between the 1/2~1/3 of normal range (NR);Poor (+++), in normal range (NR) Less than 1/3.
1.3 packet
Osteoarticular injury patient 50, soft tissue injury patient 50 are observed altogether, and study subject is randomly divided into two groups, it is right According to group 50 (each 25 of osteoarticular injury, soft tissue injuries), treatment group 50 (osteoarticular injury, soft tissue injury each 25 Example), the not statistically significant difference (P > 0.05) such as age of control group and treatment group, sex, the course of disease, symptom, have comparable Property.
1.4 treatment method
Control group:Zhenjiang plaster treatment affected part, 1 time a day, 2 weeks are a course for the treatment of.
Treatment group:The Chinese medicine of embodiment 1, hot compress or washout affected part, each 1 time of morning and evening daily, 2 weeks are a course for the treatment of.
2. efficacy analysis
2.1 criterion of therapeutical effect
Recovery from illness:1 course for the treatment of of the topical application of drug, pain, swelling disappear, and movable function scope is normal;It is effective:1 course for the treatment of of the topical application of drug, pain Bitterly, swelling substantially mitigates or disappeared, and movable function scope is switched to (+) by (+++);Effectively:1 course for the treatment of of the topical application of drug, pain, swelling subtract Gently, movable function scope is switched to (++) by (+++);It is invalid:1 course for the treatment of of the topical application of drug, local symptom is without improvement.
2.2 treatment results
After treatment, the patient symptom of control group and treatment group before treatment relative to making moderate progress, P < 0.05;Treatment group The effect of be substantially better than control group, P < 0.05.Concrete outcome is as shown in table 1, table 2, table 3.
The comparison of average onset time after 1 two groups of medications of table
The comparison of 2 two groups of symptom extinction times of table
The comparison of 3 two groups of patient's general curative effects of table
Described above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art Member, on the premise of the inventive method is not departed from, can also make some improvement and supplement, and these are improved and supplement also should be regarded as Protection scope of the present invention.

Claims (4)

1. a kind of treat Bones and joints and the Chinese medicine of soft tissue injury, it is characterised in that described Chinese medicine by following parts by weight original Material medicine is made:12 parts of the root of Chinese clematis, 12 parts of the rhizome of davallia, 12 parts of caulis piperis futokadsurae, 10 parts of root tuber of aromatic turmeric, 12 parts of lycopodium calvatum, 10 parts of the root of kudzu vine, teasel root 10 Part, 10 parts of paniculate swallowwort, 5 parts of Chinese ephedra, windproof 10 parts, 6 parts of cassia twig, 10 parts of Canton love-pea vine, 10 parts of root of Chinese trichosanthes, 8 parts of semen brassicae, safflower 5 Part, 10 parts of golden cypress, 6 parts of Ligusticum wallichii, 12 parts of Radix Angelicae Sinensis, 10 parts of the dried rhizome of rehmannia.
2. application of the Chinese medicine according to claim 1 in the medicine for preparing treatment osteoarticular injury.
3. application of the Chinese medicine according to claim 1 in the medicine for preparing treatment soft tissue injury.
4. according to any described application of Claims 2 or 3, it is characterised in that described pharmaceutical dosage form is tincture, spirit, powder Agent, lotion, finish, emulsion, ointment, paste, plaster, plastics, gel, aerosol or Babu cream.
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中医期刊治疗膝关节骨关节炎方剂用药特点分析;姚共和等;《湖南中医学院学报》;20051231;第25卷(第6期);第54-56页 *

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