CN107551229A - A kind of pharmaceutical composition and its production and use - Google Patents
A kind of pharmaceutical composition and its production and use Download PDFInfo
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- CN107551229A CN107551229A CN201710996693.8A CN201710996693A CN107551229A CN 107551229 A CN107551229 A CN 107551229A CN 201710996693 A CN201710996693 A CN 201710996693A CN 107551229 A CN107551229 A CN 107551229A
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Abstract
The invention discloses a kind of pharmaceutical composition, and it is the preparation being prepared by the raw material of following weight proportioning：12 18 parts of notopterygium root, 12 18 parts of levisticum, 12 18 parts of turmeric, 12 18 parts of frankincense, 12 18 parts of peach kernel, 12 18 parts of myrrh, 24 parts of asarum, 12 18 parts of Radix Angelicae Sinensis, 12 18 parts of Ligusticum wallichii, 12 18 parts of safflower, 12 18 parts of rhizoma cibotii, 12 18 parts of reticulate millettia, 12 18 parts of radix cyathulae, 12 18 parts of lycopodium calvatum, 12 18 parts of the bark of eucommia, 12 18 parts of the root of Dahurain angelica, 12 18 parts of rascal, 12 18 parts of excrementum pteropi, 12 18 parts of rhizoma cyperi.Also disclose the preparation method and purposes of foregoing pharmaceutical composition.Pharmaceutical composition of the present invention can be obviously improved the symptom of joint of vertebral column Disease, effectively treat joint of vertebral column disease, have no toxic side effect, have stronger actual application value.
Description
Technical field
The present invention relates to drug field, and in particular to a kind of medicine for treating joint of vertebral column disease.
Background technology
Joint of vertebral column disease is to include ankylosing spondylitis, adjuvant arthritis, psoriatic arthritis, inflammatory bowel disease correlation
Arthritis including one group of joint disease, show as arthralgia, stiff and limitation of activity, knee, ankle, foot are most often to be involved more
Joint, be often asymmetric distribution.Waist and sacrum pain is also common sympton, and it can emit to buttocks and huckle, lie up
With it is inactive when aggravate.Partly serious, chronic and recurrent exerbation patient spine will suffer from as the position of main involvement, early stage
Person can have pleurisy sample pectoralgia, and patients with terminal then shows as back, the stiff and activity of neck reduces.
The therapeutic purposes of SpA are to slow down pain, relief of symptoms and prevention to disable.At present, western medical treatment backbone
The medicine of joint disease mainly uses acts on antirheumatic or cell toxicity medicament slowly, such as SASP, methotrexate (MTX), this
A little medicines have larger toxic side effect, and Long-term taking medicine will bring larger damage to human body.
Traditional traditional Chinese medical science viewpoint thinks that joint of vertebral column disease belongs to categories such as " bi Zheng " " hot numbness " " heumatisms ".Treated from treatment
Seen in effect, tcm treatment method can obviously improve the clinical symptoms of joint of vertebral column Disease, curative for effect.Wang Yuan etc., " herbal fumigation
Influence to rats with arthritis resist inflammation on repercussive function and Mediators of inflammation " Anhui Chinese Medicine College journal the 1st phase in 2006 discloses one
Kind treats the pharmaceutical composition of adjuvant-induced arthritis, and it is consisted of：Each 20g of notopterygium root, levisticum, Ligusticum wallichii, turmeric, bush, prevent
Each 15g of wind, cassia twig, caulis piperis futokadsurae, paniculate swallowwort each 30g, asarum 10g, borneol 1g.Application number：201410131369.6 invention name
Claim：A kind of to treat bone, Qiang's drug composition of joint disease, it is made of the raw material using following weight proportion：Notopterygium root 30-40
Part, Radix Angelicae Sinensis 35-45 parts, folium artemisiae argyi 120-180 parts, grass-leaved sweetflag 120-180 parts, borneol 10-20 parts, rheum officinale 15-21 parts, Rhizoma Sparganii 30-
40 parts, curcuma zedoary 30-40 parts, root of Chinese clematis 30-40 parts, dried venom of toads 15-21 parts, cat bone 15-20 parts.
Now have no notopterygium root, levisticum, turmeric, frankincense, peach kernel, myrrh, asarum, Radix Angelicae Sinensis, Ligusticum wallichii, safflower, rhizoma cibotii, chicken blood
Rattan, radix cyathulae, lycopodium calvatum, the bark of eucommia, the root of Dahurain angelica, rascal, excrementum pteropi and rhizoma cyperi coordinate the report for treating joint of vertebral column disease.
The content of the invention
The invention provides a kind of pharmaceutical composition for treating joint of vertebral column disease, and its production and use.
The invention provides a kind of pharmaceutical composition, it is characterised in that：It is by following weight proportioning raw material prepare and
Into preparation：Notopterygium root 12-18 parts, levisticum 12-18 parts, turmeric 12-18 parts, frankincense 12-18 parts, peach kernel 12-18 parts, myrrh 12-
18 parts, asarum 2-4 parts, Radix Angelicae Sinensis 12-18 parts, Ligusticum wallichii 12-18 parts, safflower 12-18 parts, rhizoma cibotii 12-18 parts, reticulate millettia 12-18 parts,
Radix cyathulae 12-18 parts, lycopodium calvatum 12-18 parts, bark of eucommia 12-18 parts, root of Dahurain angelica 12-18 parts, rascal 12-18 parts, excrementum pteropi 12-18
Part, rhizoma cyperi 12-18 parts.
Wherein, the weight proportion of the raw material is：15 parts of notopterygium root, 15 parts of levisticum, 15 parts of turmeric, 15 parts of frankincense, peach kernel 15
Part, 15 parts of myrrh, 3 parts of asarum, 15 parts of Radix Angelicae Sinensis, 15 parts of Ligusticum wallichii, 15 parts of safflower, 15 parts of rhizoma cibotii, 15 parts of reticulate millettia, radix cyathulae 15
Part, 15 parts of lycopodium calvatum, 15 parts of the bark of eucommia, 15 parts of the root of Dahurain angelica, 15 parts of rascal, 15 parts of excrementum pteropi, 15 parts of rhizoma cyperi.
Wherein, the composition be with notopterygium root, levisticum, turmeric, frankincense, peach kernel, myrrh, asarum, Radix Angelicae Sinensis, Ligusticum wallichii, safflower,
Rhizoma cibotii, reticulate millettia, radix cyathulae, lycopodium calvatum, the bark of eucommia, the root of Dahurain angelica, rascal, excrementum pteropi and the crude drug of rhizoma cyperi, water extract or organic
Solvent extractable matter is active ingredient, the preparation being prepared plus pharmaceutically acceptable auxiliary material.
Wherein, the preparation is external preparation.
Wherein, the preparation is powder, gel, emplastrum, patch, tincture, lotion, liniment, plastics or paste.
Present invention also offers a kind of method for preparing foregoing pharmaceutical composition, it is comprised the following steps：
(1) bulk drug is weighed；
(2) bulk drug directly beats powder, or bulk drug is added water to cook or organic solvent extracts, and extract solution concentration, adds
Pharmaceutically acceptable auxiliary material or complementary composition are prepared into pharmaceutically conventional preparation.
The last purposes for providing foregoing pharmaceutical composition in the medicine for preparing treatment joint of vertebral column disease of the invention.
Wherein, described joint of vertebral column disease includes cervical spondylopathy, the protrasion of the lumbar intervertebral disci, the periarthritis of shoulderjoint or kneecap
Arthritis.
The present invention is promoting blood circulation and removing blood stasis using peach kernel, safflower, frankincense, myrrh as monarch drug in a prescription；Ligusticum wallichii, Radix Angelicae Sinensis, turmeric, reticulate millettia are minister
Medicine, blood-nourishing and battalion, blood-activating and qi-promoting；Notopterygium root, levisticum expelling wind and eliminating dampness, numbness relieving and pain relieving；The root of Dahurain angelica, lycopodium calvatum dispelling wind and eliminating dampness, relaxing tendons and activating collaterals；
The bark of eucommia, rhizoma cibotii, radix cyathulae filling liver kidney, strong waist and knee；Rascal, rhizoma cyperi dispersing stagnated hepatoqi, help the power of all medicine promoting blood circulations；Excrementum pteropi tonneau blood
Arteries and veins, blood stasis removing analgesic；Asarum diverging exterior cold, open space between skin and muscles.All medicines share, promoting blood circulation and removing blood stasis, promoting blood circulation and stopping pain, dispelling wind and eliminating dampness are played altogether, is relaxed
The active work(of muscle.
Pharmaceutical composition of the present invention can be obviously improved the symptom of joint of vertebral column Disease, effectively treat joint of vertebral column disease
Disease, have no toxic side effect, there is stronger actual application value.
Obviously, according to the above of the present invention, according to the ordinary technical knowledge and customary means of this area, do not departing from
Under the premise of the above-mentioned basic fundamental thought of the present invention, the modification, replacement or change of other diversified forms can also be made.
The embodiment of form by the following examples, the above of the present invention is remake further specifically
It is bright.But the scope that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to following example.It is all to be based on the above of the present invention
The technology realized belongs to the scope of the present invention.
Embodiment
The preparation of 1 pharmaceutical composition of the present invention of embodiment
Take notopterygium root 15g, levisticum 15g, turmeric 15g, frankincense 15g, peach kernel 15g, myrrh 15g, asarum 3g, Radix Angelicae Sinensis 15g, Ligusticum wallichii
15g, safflower 15g, rhizoma cibotii 15g, reticulate millettia 15g, radix cyathulae 15g, lycopodium calvatum 15g, bark of eucommia 15g, root of Dahurain angelica 15g, rascal 15g, five
Clever fat 15g, rhizoma cyperi 15g.It 19 taste medicines will dry above, and beat powder, and cross No. 1 sieve, produce.
The preparation of 2 pharmaceutical composition of the present invention of embodiment
Take notopterygium root 12g, levisticum 12g, turmeric 12g, frankincense 12g, peach kernel 12g, myrrh 12g, asarum 2g, Radix Angelicae Sinensis 12g, Ligusticum wallichii
12g, safflower 12g, rhizoma cibotii 12g, reticulate millettia 12g, radix cyathulae 12g, lycopodium calvatum 12g, bark of eucommia 12g, root of Dahurain angelica 12g, rascal 12g, five
Clever fat 12g, rhizoma cyperi 12g.It 19 taste medicines will dry above, and beat powder, and cross No. 1 sieve, produce.
The preparation of 3 pharmaceutical composition of the present invention of embodiment
Take notopterygium root 18g, levisticum 18g, turmeric 18g, frankincense 18g, peach kernel 18g, myrrh 18g, asarum 4g, Radix Angelicae Sinensis 18g, Ligusticum wallichii
18g, safflower 18g, rhizoma cibotii 18g, reticulate millettia 18g, radix cyathulae 18g, lycopodium calvatum 18g, bark of eucommia 18g, root of Dahurain angelica 18g, rascal 18g, five
Clever fat 18g, rhizoma cyperi 18g.It 19 taste medicines will dry above, and beat powder, and cross No. 1 sieve, produce.
Hereinafter beneficial effects of the present invention are proved with the mode of test example：
Test example 1：The clinical verification of the present composition
1 experiment material
1.1 Experimental agents
Pharmaceutical composition of the present invention, by notopterygium root 15g, levisticum 15g, turmeric 15g, frankincense 15g, peach kernel 15g, myrrh 15g, thin
It is pungent 3g, Radix Angelicae Sinensis 15g, Ligusticum wallichii 15g, safflower 15g, rhizoma cibotii 15g, reticulate millettia 15g, radix cyathulae 15g, lycopodium calvatum 15g, bark of eucommia 15g, white
Root of Dahurian angelica 15g, rascal 15g, excrementum pteropi 15g, rhizoma cyperi 15g compositions.It 19 taste medicines will dry above, and beat powder, and cross No. 1 sieve, produce.
1.2 patient data
Observe case totally 100.
2nd, experimental method
2.1 diagnostic criteria
Heumatism is due to worn with age, and bone, which loses, to nourish, disorder of qi and blood, and caused locally or systemically Bones and joints, which are degenerated, to be changed.It is clinical
With large joint pain, limitation of activity is primary symptom for performance.Degenerative osteoarthropathy is more common in, hypertrophy sexually revises.
Diagnosis basis：
(1) had a dull ache from the beginning of common waist-leg, spinal column, knee joint etc., bend and stretch, pitching, change one's position unfavorable, light activity is slightly slow
Solution, climate change aggravates, repeatedly touching not to be cured.
(2) insidious onset, morbidity is slow, is more common in person in middle and old age.
(3) local joint can mild swelling, often there are noise made in coughing or vomiting thorn sound or grating in joint when movable.The visible muscle of severe patient withers
Contracting.Joint deformity, the curved back of the body camel of waist.
(4) x ray photograph inspection：Showing osteoporosis, articular surface is irregular, and joint space is narrow, subchondral bony sclerosis, with
And edge lip sample changes, spur is formed.
(5) have a blood test heavy, anti-" O ", mucoprotein, rheumatoid factor etc. mutually differentiates with rheumatism numbness, Wang numbness.
(6) stagnation of blood stasis：Joint sting, sore spot are fixed, joint deformity, and activity is unfavorable, or the curved back of the body camel of waist, dim complexion.
Words are purple dark, deeptensepulse or thin puckery.
2.2 inclusive criteria
The case for meeting 1.1 section diagnostic criteria is included.
2.3 criterion of therapeutical effect：
(1) cure：Disappear, movable function recovers normal, and laboratory examination is normal.
(2) take a turn for the better：Arthralgia, swelling mitigate, and movable function takes a turn for the better.
(3) it is not cured：Arthralgia and swelling are unchanged.
2.4 specific medications are：
Adult's 60 grams of medicines every time, add in 3 kilograms of water, boil external application fumigation washing.
3 experimental results
3.1 clinical efficacy
Experimental result is as shown in table 1：
The efficacy analysis of table 1
| Group | Cure | Take a turn for the better | It is not cured | It is efficient |
| Experimental group (100 people) | 23 | 69 | 8 | 92% |
As shown in Table 1, after treatment of the patient by pharmaceutical composition of the present invention, symptom improves significantly, and effective percentage is
92%.
To sum up, pharmaceutical composition of the present invention can be obviously improved the symptom of joint of vertebral column Disease, effectively treat backbone and close
Disease is saved, has no toxic side effect, there is stronger actual application value.
Claims (8)
- A kind of 1. pharmaceutical composition, it is characterised in that：It is the preparation being prepared by the raw material of following weight proportioning：Notopterygium root 12-18 parts, levisticum 12-18 parts, turmeric 12-18 parts, frankincense 12-18 parts, peach kernel 12-18 parts, myrrh 12-18 parts, asarum 2-4 Part, Radix Angelicae Sinensis 12-18 parts, Ligusticum wallichii 12-18 parts, safflower 12-18 parts, rhizoma cibotii 12-18 parts, reticulate millettia 12-18 parts, radix cyathulae 12-18 Part, lycopodium calvatum 12-18 parts, bark of eucommia 12-18 parts, root of Dahurain angelica 12-18 parts, rascal 12-18 parts, excrementum pteropi 12-18 parts, rhizoma cyperi 12-18 Part.
- 2. pharmaceutical composition according to claim 1, it is characterised in that：The weight proportion of the raw material is：15 parts of notopterygium root, 15 parts of levisticum, 15 parts of turmeric, 15 parts of frankincense, 15 parts of peach kernel, 15 parts of myrrh, 3 parts of asarum, 15 parts of Radix Angelicae Sinensis, 15 parts of Ligusticum wallichii, safflower 15 Part, 15 parts of rhizoma cibotii, 15 parts of reticulate millettia, 15 parts of radix cyathulae, 15 parts of lycopodium calvatum, 15 parts of the bark of eucommia, 15 parts of the root of Dahurain angelica, 15 parts of rascal, five spirits 15 parts of fat, 15 parts of rhizoma cyperi.
- 3. according to the pharmaceutical composition described in any one of claim 1 or 2, it is characterised in that：The composition be with notopterygium root, Levisticum, turmeric, frankincense, peach kernel, myrrh, asarum, Radix Angelicae Sinensis, Ligusticum wallichii, safflower, rhizoma cibotii, reticulate millettia, radix cyathulae, lycopodium calvatum, the bark of eucommia, The root of Dahurain angelica, rascal, excrementum pteropi and the crude drug of rhizoma cyperi, water extract or extractive with organic solvent are active ingredient, plus pharmaceutically The preparation that acceptable auxiliary material is prepared.
- 4. pharmaceutical composition according to claim 3, it is characterised in that：The preparation is external preparation.
- 5. pharmaceutical composition according to claim 4, it is characterised in that：The preparation be powder, gel, emplastrum, Patch, tincture, lotion, liniment, plastics or paste.
- A kind of 6. method for preparing Claims 1 to 5 any one pharmaceutical composition, it is characterised in that：It is comprised the following steps：(1) bulk drug is weighed；(2) bulk drug directly beats powder, or bulk drug is added water to cook or organic solvent extracts, and extract solution concentration, adds pharmacy Upper acceptable auxiliary material or complementary composition are prepared into pharmaceutically conventional preparation.
- 7. purposes of the Claims 1 to 5 any one pharmaceutical composition in the medicine for preparing treatment joint of vertebral column disease.
- 8. purposes according to claim 7, it is characterised in that：Described joint of vertebral column disease is included between cervical spondylopathy, lumbar vertebrae Disc protrusion, the periarthritis of shoulderjoint or knee osteoarthritis.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2017106141191 | 2017-07-25 | ||
| CN201710614119 | 2017-07-25 |
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| CN107551229A true CN107551229A (en) | 2018-01-09 |
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| Application Number | Title | Priority Date | Filing Date |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110638862A (en) * | 2019-09-09 | 2020-01-03 | 山东博奥克生物科技有限公司 | Plaster and preparation method thereof |
| CN110812464A (en) * | 2019-12-26 | 2020-02-21 | 陕西中医药大学 | Pharmaceutical composition for preventing and treating arthritis and preparation method thereof |
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| CN1586504A (en) * | 2004-06-29 | 2005-03-02 | 朱增云 | Paste for promoting blood circulation to stop pain |
| CN103127458A (en) * | 2013-02-05 | 2013-06-05 | 杨连生 | Drug for treating osteoarticular myalgia |
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2017
- 2017-10-19 CN CN201710996693.8A patent/CN107551229A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1586504A (en) * | 2004-06-29 | 2005-03-02 | 朱增云 | Paste for promoting blood circulation to stop pain |
| CN103127458A (en) * | 2013-02-05 | 2013-06-05 | 杨连生 | Drug for treating osteoarticular myalgia |
Non-Patent Citations (1)
| Title |
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| 周安方: "痛证的辨治思路与经验", 《天津中医药大学学报》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110638862A (en) * | 2019-09-09 | 2020-01-03 | 山东博奥克生物科技有限公司 | Plaster and preparation method thereof |
| CN110812464A (en) * | 2019-12-26 | 2020-02-21 | 陕西中医药大学 | Pharmaceutical composition for preventing and treating arthritis and preparation method thereof |
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Application publication date: 20180109 |
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