CN110638862A

CN110638862A - Plaster and preparation method thereof

Info

Publication number: CN110638862A
Application number: CN201910848704.7A
Authority: CN
Inventors: 翟逸; 吴永坤; 尹训军; 许彤; 赵秀敏; 刘孟刚; 李明; 刘钦松
Original assignee: SHANDONG BOAOKE BIOTECHNOLOGY CO Ltd
Current assignee: SHANDONG BOAOKE BIOTECHNOLOGY CO Ltd
Priority date: 2019-09-09
Filing date: 2019-09-09
Publication date: 2020-01-03

Abstract

The invention discloses a plaster and a preparation method thereof, wherein the plaster comprises the following medicinal raw materials in parts by weight: 200 portions of Szechuan lovage rhizome, 200 portions of achyranthes root, 300 portions of east Asian tree fern rhizome, 200 portions of suberect spatholobus stem, 300 portions of common clubmoss herb, 150 portions of cortex acanthopanacis, 200 portions of Chinese taxillus twig, 300 portions of doubleteeth pubescent angelica root, 400 portions of large-leaved gentian, 200 portions of divaricate saposhnikovia root, 350 portions of divaricate saposhnikovia root, 100 portions of cassia bark, 200 portions of myrrh, 200 portions of borneol, and 1200 portions of substrate. The preparation process of the plaster comprises the following steps: 1) crushing, soaking and cooking the traditional Chinese medicine raw materials for the first time; 2) concentrating the first distillate for the second time; 3) low-temperature drying for extracting active substances; 4) preparing an aqueous solution of the dried extract; 5) crushing borneol; 6) mixing the extract and Borneolum Syntheticum powder with matrix, and making plaster.

Description

Plaster and preparation method thereof

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and relates to a plaster and a preparation method thereof.

Background

In recent years, the social development is rapid, the life pace is accelerated continuously, the life and working pressure of people is increased continuously, and the fact that people sit and stand for a long time and stay up overnight for overtime and overtime becomes inevitable. Meanwhile, due to the bad living habits such as long-time air conditioning cold air blowing and unreasonable movement, a lot of people suffer from chronic diseases such as cervical spondylosis, lumbar spondylosis, hyperosteogeny, scapulohumeral periarthritis, rheumatic bone diseases and the like. These diseases usually require long-term treatment, and the current treatment methods cannot completely cure these conditions, thereby imposing a heavy economic burden and long-term mental distress on patients. At present, many patients prefer to apply external plaster for treating or assisting in treating the diseases, but the plaster on the market has various types, the preparation quality is also uneven, and the curative effect is difficult to ensure.

The black plaster is a medicinal preparation in traditional Chinese medicine, generally has the effect of treatment by directly absorbing active medicinal ingredients into the affected part through contact with the skin, is recorded in ancient book representatives in the past, and is still widely used in traditional Chinese medicine clinics and folks at present. The preparation of the black plaster mainly comprises the steps of frying the lead, refining oil, discharging the lead, removing fire toxin, spreading the plaster and the like. The traditional preparation processes are complex and tedious to operate, the manufacture is usually controlled through family transmission or by experience accumulated all year round, and the manufacture is not easy to master by ordinary people. Importantly, the 'oil refining' process in the preparation of the black plaster needs high temperature for a long time, which greatly damages the medicinal components and greatly influences the curative effect. Therefore, the conventional plaster needs to be improved in the preparation process to achieve better therapeutic effect.

Disclosure of Invention

Aiming at the existing problems, the invention provides a plaster which has good drug effect and has obvious effect on treating chronic diseases such as cervical spondylosis, lumbar spondylosis, scapulohumeral periarthritis, rheumatoid bone diseases and the like and a preparation method thereof.

The invention provides a plaster which is characterized by comprising ligusticum wallichii, achyranthes root, rhizoma cibotii, caulis spatholobi, lycopodium clavatum, cortex acanthopanacis, parasitic loranthus, radix angelicae pubescentis, radix gentianae macrophyllae, radix sileris, cinnamon, myrrh, borneol and matrix.

Specifically, the plaster comprises the following components in parts by weight: 200 portions of Szechuan lovage rhizome, 200 portions of achyranthes root, 300 portions of east Asian tree fern rhizome, 200 portions of suberect spatholobus stem, 300 portions of common clubmoss herb, 150 portions of cortex acanthopanacis, 200 portions of Chinese taxillus twig, 300 portions of doubleteeth pubescent angelica root, 400 portions of large-leaved gentian, 200 portions of divaricate saposhnikovia root, 350 portions of divaricate saposhnikovia root, 100 portions of cassia bark, 200 portions of myrrh, 200 portions of borneol, and 1200 portions of substrate.

Preferably a plaster comprising the following components in parts by weight: 250 parts of ligusticum chuanxiong hort, 300 parts of radix achyranthis bidentatae, 350 parts of rhizoma cibotii, 250 parts of caulis spatholobi, 350 parts of lycopodium clavatum, 200 parts of cortex acanthopanacis, 250 parts of parasitic loranthus, 350 parts of radix angelicae pubescentis, 150 parts of radix gentianae macrophyllae, 300 parts of radix sileris, 150 parts of cortex cinnamomi, 150 parts of myrrh, 100 parts of borneol and 1000 parts of matrix.

Another object of the present invention is to provide a method for preparing a plaster, comprising the steps of:

(1) pulverizing the above materials (except Borneolum Syntheticum) with a micronizer, transferring into a container, adding appropriate amount of purified water, soaking for 20-30min, steaming for 30-60min, and collecting distillate;

(2) transferring the distillate prepared in the step (1) into another container, cooking for 30-60min, and collecting secondary distillate;

(3) drying the filtrate prepared in the step (2) by a low-temperature spray dryer to obtain an extracted dry matter;

(4) dissolving the extracted dried substance obtained in the step (3) with a proper amount of purified water for later use;

(5) pulverizing Borneolum Syntheticum into fine powder;

(6) slowly adding the dissolving solution prepared in the step (4) into the heated and melted matrix, and fully stirring until the dissolving solution is uniformly mixed to prepare the ointment;

(7) adding the borneol fine powder in the step (5) into the ointment prepared in the step (6), and stirring until the borneol fine powder and the ointment are uniformly mixed;

(8) transferring the mixture prepared in the step (7) into a plaster blank paste while the paste is hot, spreading and attaching silicone oil paper to the paste blank paste, and preparing a finished plaster product.

The further optimized preparation method comprises the step (1) of crushing and soaking the Chinese medicinal raw materials, wherein the steaming conditions are-0.04 ~ -0.07Mpa and 80-95 ℃.

The further optimized preparation method comprises the step (2) of crushing and soaking the Chinese medicinal raw materials, wherein the cooking conditions are-0.05 ~ -0.08Mpa and the temperature is 60-80 ℃.

The preparation method is further preferred, wherein the low-temperature spray drying temperature in the step (3) is 60-80 ℃.

Further preferable is a preparation method, wherein in the step (5), the borneol is crushed to be capable of passing through a sieve of 100-150 meshes.

In the preparation process of the plaster, a water immersion extraction method and a low-temperature drying method are adopted for raw materials, so that compared with the traditional frying method, the damage to heat-sensitive effective ingredients in medicinal materials is reduced, the medicinal effect is better kept, and meanwhile, the plaster is easier to prepare in a standardized large scale.

The traditional Chinese medicine raw materials have the effects of dispelling wind and eliminating dampness, promoting blood circulation and removing stasis, tonifying liver and kidney, strengthening waist and knees, diminishing inflammation and easing pain and the like, and the medicine effect can play a synergistic role through optimized combination, so that the disease of a patient can be quickly improved. The plaster has obvious curative effect on common chronic diseases such as cervical spondylosis, lumbar spondylosis, hyperosteogeny, scapulohumeral periarthritis, rheumatoid bone diseases and the like.

Detailed Description

The present invention will be explained in more detail with reference to the following examples, but the present invention is not limited to these examples, and the present invention is not limited to these examples in any way.

Example 1

A plaster consisting of the following formulation was prepared:

250g of ligusticum chuanxiong hort, 300g of achyranthes bidentata, 350g of rhizoma cibotii, 250g of caulis spatholobi, 350g of lycopodium clavatum, 200g of cortex acanthopanacis, 250g of parasitic loranthus, 350g of radix angelicae pubescentis, 150g of radix gentianae macrophyllae, 300g of radix sileris, 150g of cinnamon, 150g of myrrh, 100g of borneol and 1000g of matrix.

Pulverizing the above materials (except Borneolum Syntheticum) with micronizer, transferring into container, adding appropriate amount of purified water, soaking for 25min, decocting at-0.06 Mpa at 90 deg.C for 55min, and collecting distillate; transferring the obtained distillate into another container, steaming under-0.08 Mpa at 70 deg.C for 50min, and collecting secondary distillate; drying the obtained filtrate at 55 deg.C in a low temperature spray dryer to obtain dried extract; dissolving the obtained dried extract with appropriate amount of purified water; pulverizing Borneolum Syntheticum to powder capable of sieving with 120 mesh sieve; slowly adding the dried hydrolysate into the matrix, and stirring to obtain unguent; adding the pulverized Borneolum fine powder into the prepared unguent, and stirring to mix well; transferring the mixture into a plaster blank paste while the paste is hot, spreading and attaching silicone oil paper to the paste blank paste to obtain a finished plaster product.

Example 2

A plaster consisting of the following formulation was prepared:

220g of ligusticum chuanxiong hort, 280g of achyranthes bidentata, 330g of rhizoma cibotii, 220g of caulis spatholobi, 330g of lycopodium clavatum, 170g of cortex acanthopanacis, 220g of parasitic loranthus, 320g of radix angelicae pubescentis, 130g of radix gentianae macrophyllae, 270g of radix sileris, 120g of cinnamon, 120g of myrrh, 70g of borneol and 850g of substrate.

Pulverizing the above materials (except Borneolum Syntheticum) with micronizer, transferring into container, adding appropriate amount of purified water, soaking for 20min, decocting at-0.06 Mpa and 80 deg.C for 60min, and collecting distillate; transferring the obtained distillate into another container, steaming at-0.06 Mpa and 70 deg.C for 40min, and collecting secondary distillate; drying the obtained filtrate at 60 deg.C in a low temperature spray dryer to obtain dried extract; dissolving the obtained dried extract with appropriate amount of purified water; pulverizing Borneolum Syntheticum to powder capable of being sieved with 100 mesh sieve; slowly adding the dried hydrolysate into the matrix, and stirring to obtain unguent; adding the pulverized Borneolum fine powder into the prepared unguent, and stirring to mix well; transferring the mixture into a plaster blank paste while the paste is hot, spreading and attaching silicone oil paper to the paste blank paste to obtain a finished plaster product.

Example 3

A plaster consisting of the following formulation was prepared:

280g of ligusticum chuanxiong hort, 340g of achyranthes bidentata, 390g of rhizoma cibotii, 280g of suberect spatholobus stem, 390g of lycopodium clavatum, 220g of cortex acanthopanacis, 280g of parasitic loranthus, 390g of radix angelicae pubescentis, 150g of large-leaved gentian, 330g of divaricate saposhnikovia root, 170g of cinnamon, 170g of myrrh, 120g of borneol and 1100g of substrate.

Pulverizing the above materials (except Borneolum Syntheticum) with micronizer, transferring into container, adding appropriate amount of purified water, soaking for 20min, decocting at-0.05 Mpa and 85 deg.C for 50min, and collecting distillate; transferring the obtained distillate into another container, steaming under-0.05 Mpa at 60 deg.C for 60min, and collecting secondary distillate; drying the obtained filtrate at 60 deg.C in a low temperature spray dryer to obtain dried extract; dissolving the obtained dried extract with appropriate amount of purified water; pulverizing Borneolum Syntheticum to 150 mesh powder; slowly adding the dried hydrolysate into the matrix, and stirring to obtain unguent; adding the pulverized Borneolum fine powder into the prepared unguent, and stirring to mix well; transferring the mixture into a plaster blank paste while the paste is hot, spreading and attaching silicone oil paper to the paste blank paste to obtain a finished plaster product.

Example 4

A plaster consisting of the following formulation was prepared:

200g of ligusticum chuanxiong hort, 200g of achyranthes bidentata, 300g of rhizoma cibotii, 200g of caulis spatholobi, 300g of lycopodium clavatum, 150g of cortex acanthopanacis, 200g of parasitic loranthus, 300g of radix angelicae pubescentis, 100g of radix gentianae macrophyllae, 250g of radix sileris, 100g of cinnamon, 100g of myrrh, 100g of borneol and 800 g of matrix.

Pulverizing the above materials (except Borneolum Syntheticum) with micronizer, transferring into container, adding appropriate amount of purified water, soaking for 30min, decocting at 95 deg.C under-0.07 Mpa for 30min, and collecting distillate; transferring the obtained distillate into another container, steaming at-0.08 Mpa and 80 deg.C for 50min, and collecting secondary distillate; drying the obtained filtrate at 70 deg.C in a low temperature spray dryer to obtain dried extract; dissolving the obtained dried extract with appropriate amount of purified water; pulverizing Borneolum Syntheticum to powder capable of sieving with 120 mesh sieve; slowly adding the dried hydrolysate into the matrix, and stirring to obtain unguent; adding the pulverized Borneolum fine powder into the prepared unguent, and stirring to mix well; transferring the mixture into a plaster blank paste while the paste is hot, spreading and attaching silicone oil paper to the paste blank paste to obtain a finished plaster product.

Example 5

A plaster consisting of the following formulation was prepared:

300g of ligusticum chuanxiong hort, 350g of achyranthes bidentata, 450g of rhizoma cibotii, 300g of caulis spatholobi, 450g of lycopodium clavatum, 250g of cortex acanthopanacis, 300g of parasitic loranthus, 400g of radix angelicae pubescentis, 200g of radix gentianae macrophyllae, 350g of radix sileris, 200g of cinnamon, 200g of myrrh, 200g of borneol and 1200g of matrix.

Pulverizing the above materials (except Borneolum Syntheticum) with micronizer, transferring into container, adding appropriate amount of purified water, soaking for 25min, decocting at-0.04 Mpa at 90 deg.C for 40min, and collecting distillate; transferring the obtained distillate into another container, steaming under-0.07 Mpa at 70 deg.C for 30min, and collecting secondary distillate; drying the obtained filtrate at 80 deg.C in a low temperature spray dryer to obtain dried extract; dissolving the obtained dried extract with appropriate amount of purified water; pulverizing Borneolum Syntheticum to 140 mesh powder; slowly adding the dried hydrolysate into the matrix, and stirring to obtain unguent; adding the pulverized Borneolum fine powder into the prepared unguent, and stirring to mix well; transferring the mixture into a plaster blank paste while the paste is hot, spreading and attaching silicone oil paper to the paste blank paste to obtain a finished plaster product.

Comparative example 1

The other components, component contents and preparation methods were the same as in example 1, except that the chuanxiong rhizome was omitted.

Comparative example 2

Except that the ligusticum chuanxiong hort and the achyranthes bidentata were omitted, other components, component contents and preparation methods were the same as those of example 1.

Comparative example 3

The ingredients, the contents of the ingredients and the preparation method were the same as those of example 1 except that chuanxiong rhizome, achyranthes root and east Asian tree fern were omitted.

Experimental example 1

In order to verify the clinical efficacy, 160 patients with cervical spondylosis were selected and divided into 8 groups of 20 persons each, wherein the 1 st, 2 nd, 3 rd, 4 th and 5 th groups were the administration groups of examples 1 to 5, and the 6 th, 7 th and 8 th groups were the administration groups of comparative example 1, comparative example 2 and comparative example 3.

Specific clinical data are as follows:

1. patient data: 160 patients, age 50-74 years, 80 men and 80 women, were randomly divided into 8 groups and numbered 1, 2, 3, 4, 5, 6, 7, 8, wherein 1, 2, 3, 4, 5 groups were the administration groups of examples 1-5, the test groups 1-5, 7, 8 groups were the administration groups of comparative example 1, comparative example 2 and comparative example 3, and the control groups 1-3.

2. Diagnostic criteria: according to the diagnosis standard of cervical spondylosis-the special topic of cervical spondylosis conference (Guilin 5 months in 1984), the diagnosis of the nerve root type and the vertebral artery type of the cervical spondylosis is met:

(1) different degrees of pain and numbness of the neck, the shoulder, the back and the upper limbs are clinically shown; limited neck movement, cervical vertigo, headache, nausea, tinnitus and other symptoms;

(2) the cervical spine or the side of the spine has pressure pain, the intervertebral foramen compression test is positive, the brachial plexus traction test is positive, and the cervical rotation test is positive;

(3) x-ray positive, oblique and lateral radiography of cervical vertebra to prompt hyperosteogeny of cervical vertebra centrum, or narrowing of intervertebral space, hyperosteogeny of uncinate vertebra joint, intervertebral foramen narrowing, calcification of cervical vertebra ligament and change of physiological curvature of cervical vertebra;

(4) the transcranial ultrasonic Doppler TCD examination indicates that the vertebro-basilar artery has insufficient blood supply.

3. The medication method comprises the following steps:

test groups: the plaster prepared in the embodiment 1-5 is externally applied, heated and softened, and respectively stuck to the affected parts of 1 group of patients, 2 groups of patients, 3 groups of patients, 4 groups of patients and 5 groups of patients, wherein each sticking is carried out for 7 days, 2 sticking is a treatment course, and the statistical treatment effect is observed after 4 treatment courses of continuous use;

control group: the plaster prepared in the comparative examples 1-3 is externally applied, heated and softened, and respectively stuck to the affected parts of 6, 7 and 8 groups of patients, wherein each sticking is carried out for 7 days, 2 sticks are taken as a treatment course, and the statistical treatment effect is observed after 4 treatment courses of continuous use.

4. The evaluation standard of the curative effect is as follows: refer to the standard of curative effect for diagnosing the disease of traditional Chinese medicine and the guiding principle of clinical research of new traditional Chinese medicine of the Ministry of health of the people's republic of China, and combine the comprehensive judgment of symptoms, sign integral, TCD, X-ray examination and the like.

(1) Clinical cure: the symptoms and the physical signs are completely disappeared, the function is recovered to be normal, the TCD is basically normal or the X-ray radiography is obviously improved, and the integral improvement rate of the symptoms and the physical signs is more than 95 percent.

(2) The effect is shown: the symptoms and physical signs basically disappear, TCD is obviously changed or X-ray radiography is carried out to improve, and the integral improvement rate of the symptoms and physical signs is 65-95 percent.

(3) The method has the following advantages: the improvement rate of symptoms and signs integration is 30-65% for patients with symptoms and signs improvement and TCD and X-ray examination improvement.

(4) And (4) invalidation: the improvement rate of symptoms and signs is below 30 percent, and the TCD and X-ray examination are not changed.

The integrated improvement rate is (pre-treatment integration-post-treatment integration) ÷ pre-treatment integration × 100%.

Symptoms, signs scores and disease grading criteria:

local pain

And (3) normal: the score 0 indicates no pain in the limbs and disappearance of pain after treatment.

Mild: the pain was slightly relieved when the patient was stationary, and the weight was increased when the patient was moving, which was 1 point.

Medium: pain is felt when static, and aggravated when moving, 2 points.

And (3) severe degree: the number of patients who had pain at rest and were unwilling to move was 3.

Tenderness

And (3) normal: for those without tenderness, the score is 0.

Mild: for local tenderness, it is 1 point.

Medium: for pronounced local tenderness, 2 points are given.

And (3) severe degree: those with severe or tenderness local tenderness are divided into 3 points.

The specific results are shown in the following table:

item	Recovery method	Show effect	Is effective	Invalidation	Cure rate (%)	Effective rate (%)
							Test group 1	10	6	2	2	55.0	90.0
Test group 2	11	5	3	1	55.0	95.0
							Test group 3	12	5	2	1	55.0	95.0
Test group 4	12	6	1	1	55.0	95.0
							Test group 5	11	5	2	2	55.0	90.0
Control group 1	9	7	2	2	45.0	90.0
							Control group 2	8	7	2	3	40.0	85.0
Control group 3	7	8	1	4	35.0	80.0

As can be seen from the data in the table, the cure rate and the effective rate of the plaster of the invention used in the examples 1-5 are higher than those of the comparative examples 1-3, and the comparative examples 1-3 show that the added ligusticum wallichii, the achyranthes root and the rhizoma cibotii have a synergistic effect, and the cure rate and the effective rate can be influenced by one of the three components.

Experimental example 2

Clinical typical cases:

case 1: jia somewhere, woman, 46 years old, suffer from cervical spondylopathy, CT examination cervical disc protrusion, swell, oppress nerve cause upper limbs pain, numbness, can't dry farm work and do housework normally, 2009 10 months 20 coming clinic treatment, paste 3 postpastes disease relief of plaster (example 1 preparation) of the invention, treat 6 months after insisting on, fully recover, can normally do farming, return visit have recurrence.

Case 2: in Song Dynasty, male, age 30, suffered from cervical intervertebral disc protrusion, right upper limb can not be lifted, shoulder muscle atrophy, 2 month and 2 days coming clinic treatment in 2012, symptoms are obviously relieved after one plaster (prepared in example 1) is applied, and the plaster is completely cured for 3 months. Can normally work.

Case 3: when a patient suffering from lumbar disc herniation in 58 years old of a male in Dubiao fails to walk due to spinal canal stenosis and nerve compression, and the patient suffers from numbness and pain in the left leg, the patient can be treated 2 months and 5 days in 2010, the plaster (prepared in example 1) is applied, the symptoms are relieved after 3 patches, the patient is healed after half a year, and normal work and activities can be performed. Half-year return visit without relapse.

Case 4: the plaster (prepared in example 1) is used for 30 days, the symptoms are relieved, the patient can recover after 7 months of treatment, and normal activities and lives can be realized.

Case 5: when a certain decoction is used for a woman in 55 years old, pain at the knee joints of two legs cannot be squat, the patient is found to suffer from proliferative arthritis through radiography examination, the patient goes to a county hospital for treatment once, the effect is poor, the patient is treated in a clinic in 2012 and 1 month, 1 part of the plaster (prepared in example 1) is used for relieving pain, the pain basically disappears after 3 parts of the plaster, and the patient can be cured after half a year and can be normally farmed.

Case 6: certain Liu is female, aged 56 years old, and has numbness and pain in the right leg, walking difficulty, lumbar disc herniation and spinal stenosis under CT examination, which are treated in 8 months and 12 days in 2010, 3 pieces of the plaster (prepared in example 1) are used for relieving symptoms, and the plaster can heal after being insisted on for half a year of treatment, and can be normally used for activities and housework. Half-year return visit without relapse.

In conclusion, the traditional Chinese medicinal raw materials have the effects of dispelling wind and removing dampness, promoting blood circulation and removing stasis, tonifying liver and kidney, strengthening waist and knees, diminishing inflammation and easing pain and the like, and the medicine effect can play a synergistic role through optimized combination, so that the disease of a patient can be quickly improved. The plaster has obvious curative effect on common chronic diseases such as cervical spondylosis, lumbar spondylosis, hyperosteogeny, scapulohumeral periarthritis, rheumatoid bone diseases and the like.

Although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A plaster is characterized by comprising ligusticum chuanxiong hort, achyranthes bidentata, rhizoma cibotii, caulis spatholobi, lycopodium clavatum, cortex acanthopanacis, herba taxilli, radix angelicae pubescentis, radix gentianae macrophyllae, radix sileris, cinnamon, myrrh, borneol and a matrix.

2. A plaster according to claim 1, comprising the following components in the following weight ratios: 200 portions of Szechuan lovage rhizome, 200 portions of achyranthes root, 300 portions of east Asian tree fern rhizome, 200 portions of suberect spatholobus stem, 300 portions of common clubmoss herb, 150 portions of cortex acanthopanacis, 200 portions of Chinese taxillus twig, 300 portions of doubleteeth pubescent angelica root, 400 portions of large-leaved gentian, 200 portions of divaricate saposhnikovia root, 350 portions of divaricate saposhnikovia root, 100 portions of cassia bark, 200 portions of myrrh, 200 portions of borneol, and 1200 portions of substrate.

3. A plaster according to claim 1, comprising the following components in the following weight ratios: 250 parts of ligusticum chuanxiong hort, 300 parts of radix achyranthis bidentatae, 350 parts of rhizoma cibotii, 250 parts of caulis spatholobi, 350 parts of lycopodium clavatum, 200 parts of cortex acanthopanacis, 250 parts of parasitic loranthus, 350 parts of radix angelicae pubescentis, 150 parts of radix gentianae macrophyllae, 300 parts of radix sileris, 150 parts of cortex cinnamomi, 150 parts of myrrh, 100 parts of borneol and 1000 parts of matrix.

4. A process for the preparation of a plaster as claimed in any of claims 1 to 3, characterized in that it comprises the following steps:

(5) pulverizing Borneolum Syntheticum into fine powder;

5. The process for preparing a plaster as claimed in claim 4, wherein the steaming conditions after pulverizing and soaking the Chinese medicinal materials in step (1) are-0.04 ~ -0.07Mpa and 80-95 ℃.

6. The process for preparing a plaster as claimed in claim 4, wherein the steaming conditions after pulverizing and soaking the Chinese medicinal materials in step (2) are-0.05 ~ -0.08MPa and 60-80 ℃.

7. A process for producing a patch as claimed in claim 4, wherein the low-temperature spray-drying temperature in step (3) is 60 ℃ to 80 ℃.

8. The method of claim 4, wherein the step (5) of pulverizing the borneol to a powder of 100-150 mesh.