CN104491599A - 一种治疗渗出性皮肤病的中药组合物 - Google Patents

一种治疗渗出性皮肤病的中药组合物 Download PDF

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CN104491599A
CN104491599A CN201410754768.8A CN201410754768A CN104491599A CN 104491599 A CN104491599 A CN 104491599A CN 201410754768 A CN201410754768 A CN 201410754768A CN 104491599 A CN104491599 A CN 104491599A
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吴燕
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Abstract

本发明公开了一种治疗渗出性皮肤病的中药组合物，由以下重量配比的药材制备而成：野菊花30份、马齿苋25份、生地榆20份、苦参15份、黄柏20份、蛇床子30份、熊脂10份、奶草5份、猪鬃松叶15份、椭圆叶花锚6份、耳叶金毛裸蕨5份、阿摩尼亚脂4份、猪胆粉5份。临床实验证明，本发明通过选择合适的药材及其配比，本发明中药组合物具有和胃降逆、理气除湿、补胃润肠之功效治疗渗出性皮肤病治愈率极高，且成本低廉、安全无毒副作用。

Description

一种治疗渗出性皮肤病的中药组合物
技术领域
  本发明涉及一种中药组合物，具体涉及一种治疗渗出性皮肤病的中药组合物。
背景技术
反流性食管炎（RE）是由胃、十二指肠内容物反流入食管引起的食管炎症性病变，内镜下表现为食管黏膜的破损，即食管糜烂和（或）食管溃疡。反流性食管炎可发生于任何年龄的人群，成人发病率随年龄增长而升高。近二十年全球的发病率都有上升趋势。临床上对该疾病的治疗，一般以西医为主，但是大部分药剂药效不显，对于渗出性皮肤病的治疗效果不显著。
发明内容
本发明旨在提供一种治疗渗出性皮肤病的中药组合物，其选用药材配伍相宜，符合中医药及现代医学研究理论，本发明中药组合物具有和胃降逆、理气除湿、补胃润肠之功效，治疗渗出性皮肤病治愈率极高且安全无毒副作用。
为了达到上述目的，本发明采用以下技术方案：一种治疗渗出性皮肤病的中药组合物，由以下重量配比的药材制备而成：党参15～16份、煅乌贼骨15～16份、茯苓8～9份、白术8～9份、法半夏8～9份、黄芩8～9份、枳壳8～9份、厚朴8～9份、柴胡8～9份、蒲公英8～9份、炙甘草6～7份、奶桃35～40份、炼山石0～7份、麦糵5～6份、云扣莲4～5份、卤盐0～6份、小叶锦鸡儿0～6份、奶皮4～5份。
作为优选，由以下重量配比的药材制备而成：党参15～16份、煅乌贼骨15～16份、茯苓8～9份、白术8～9份、法半夏8～9份、黄芩8～9份、枳壳8～9份、厚朴8～9份、柴胡8～9份、蒲公英8～9份、炙甘草6～7份、奶桃35～40份、炼山石6～7份、麦糵5～6份、云扣莲4～5份、卤盐5～6份、小叶锦鸡儿5～6份、奶皮4～5份。
作为优选，由以下重量配比的药材制备而成：党参15份、煅乌贼骨15份、茯苓8份、白术8份、法半夏8份、黄芩8份、枳壳8份、厚朴8份、柴胡8份、蒲公英8份、炙甘草6份、奶桃35份、炼山石6份、麦糵5份、云扣莲4份、卤盐5份、小叶锦鸡儿5份、奶皮4份。
一种治疗渗出性皮肤病的中药组合物的制备方法，包括如下步骤：（1）将党参、茯苓、白术、法半夏、黄芩、枳壳、厚朴、柴胡、蒲公英、奶桃、炼山石、麦糵、云扣莲、小叶锦鸡儿洗净，放入容器内，加入8～10倍量的蒸馏水，浸泡5～6小时后，煮沸3～4小时，提取；再次加入6～8倍量蒸馏水，煮沸2～3小时，提取；最后，加入4～6倍量蒸馏水，加热煮沸1～2小时，提取；合并三次提取液，过滤，得滤液，浓缩成60℃下相对密度为1.10～1.16的稠膏，备用；（2）将煅乌贼骨和炙甘草进行混合，混合均匀后进行粉碎处理，研末，过160目细粉，备用；（3）将卤盐、奶皮放入容器内，加入黄酒，并加入少量蜂蜜，搅拌均匀，经容器密封，隔水加热15～25min，取出，得膏体备用；（4）将上述步骤（1）～（3）所制得的稠膏、细粉以及膏体混合，制成胶囊剂。
本发明各中药成份的药理分析如下：
党参【性味】 甘，平。【归经】 归脾、肺经。【功能主治】 补中益气，健脾益肺。用于脾肺虚弱，气短心悸，食少便溏，虚喘咳嗽，内热消渴。
茯苓【性味】 甘、淡，平。【归经】 归心、肺、脾、肾经。【功能主治】 利水渗湿，健脾宁心。用于水肿尿少，痰饮眩悸，脾虚食少，便溏泄泻，心神不安，惊悸失眠。
白术【性味】苦、甘，温。【归经】 归脾、胃经。【功能主治】 健脾益气，燥湿利水，止汗，安胎。用于脾虚食少，腹胀泄泻，痰饮眩悸，水肿，自汗，胎动不安。土白术健脾，和胃，安胎。用于脾虚食少，泄泻便溏，胎动不安。
法半夏【来源】 本品为半夏的炮制加工品。【性味】 辛、温。【归经】 归脾、胃、肺经。【功能主治】 燥湿化痰。用于痰多咳喘，痰饮眩悸，风痰眩晕，痰厥头痛。
黄芩【来源】 本品为唇形科植物黄芩的干燥根。【性味】 苦，寒。【归经】 归肺、胆、脾、大肠、小肠经。【功能主治】 清热燥湿，泻火解毒，止血，安胎。用于湿温、暑温胸闷呕恶，湿热痞满，泻痢，黄疸，肺热咳嗽，高热烦渴，血热吐衄，痈肿疮毒，胎动不安。
枳壳【来源】芸香科植物酸橙及其栽培变种的干燥未成熟果实。【功能主治】 理气宽中，行滞消胀。用于胸胁气滞，胀满疼痛，食积不化，痰饮内停；胃下垂，脱肛，子官脱垂。
厚朴【来源】木兰科植物厚朴或凹叶厚朴的干燥干皮、根皮及枝皮。【功能主治】燥湿消痰，下气除满。用于湿滞伤中，脘痞吐泻，食积气滞，腹胀便秘，痰饮喘咳。
柴胡【来源】伞形科植物柴胡或狭叶柴胡的干燥根。【功能主治】和解表里，疏肝，升阳。用于感冒发热，寒热往来，胸胁胀痛，月经不调，子官脱垂，脱肛。
蒲公英【来源】本品为菊科植物蒲公英或同属数种植物的干燥全草。【性味】苦、甘，寒。【归经】归肝、胃经。【功能主治】清热解毒，消肿散结，利尿通淋。用于疔疮肿毒，乳痈，瘰疠，目赤，咽痛，肺痈，肠痈，湿热黄疸，热淋涩痛。
奶桃【来源】为棕桐科植物椰子树的成熟果实。【性味】二级湿热，味甘。【功能主治】生湿生热，增强体内自然热，生血肥体，温肾填精，补脑明目，保养胎儿，驱除肠虫，解毒除疫。
炼山石【来源】 药材基源：为中酸性火成岩类岩石石英二长斑岩。【性味】 甘；温；无毒。【归经】 肝；胃；肾经。【功能主治】 解毒散结；去腐生肌；除寒祛湿；益肝健胃；活血化瘀；利尿化石；延年益寿。主痈疽发背；痤疮；湿疹；脚气；痱子；手指皲裂；黄褐斑；牙痛；口腔溃疡；风湿痹痛；腰背痛；慢性肝炎；胃炎；痢疾；糖尿病；神经衰弱；外伤红肿；高血压；老年性血管硬化；肿瘤；尿路结石。
麦糵【来源】禾本科植物大麦的发芽颖果。【性味】 甘；平。【归经】 脾；胃经。【功能主治】 消食化积；回乳。主食积不消；腹满泄泻；恶心哎吐；食欲不振；乳汁郁积；乳房胀痛。
云扣莲【来源】为蓼科植物牛皮消蓼的根。【性味】 酸；辛；性凉。【归经】 肺；胃经。【功能主治】 敛肺止咳;行气健胃;祛风除湿。主肺痨咳嗽；痰中带血；百日咳；胃脘胀闷疼痛；风湿痹痛。
小叶锦鸡儿【来源】豆科植物小叶锦鸡儿的根。【性味】味苦，性凉。【功能主治】清热，收敛。主治高血压病，头痛，头晕，咽喉肿痛，毒热症。
煅乌贼骨【性味】 咸、涩，温。【归经】 归脾、肾经。【功能主治】 收敛止血，涩精止带，制酸，敛疮。用于胃痛吞酸，吐血衄血，崩漏便血，遗精滑精，赤白带下；溃疡病。外治损伤出血，疮多脓汁。
炙甘草【来源】取净甘草片，加入炼熟的蜂蜜与少许开水，拌匀后稍闷，炒至黄色至深黄色，不粘手时取出，晾凉。【性味】 甘，平。【归经】 归心、肺、脾、胃经 。【功能主治】 补脾和胃，益气复脉。用于脾胃虚弱，倦怠乏力，心动悸，脉结代。
卤盐【来源】卤块(固体卤水)经加工煎熬制成的白色结晶体。【性味】味咸，性热。【功能主治】温中，开欲，破痞，通便，祛巴达干赫依。主治胃痞满、胀、鸣，便秘，消化不良，呃逆，食欲不振。
奶皮【来源】水牛或黄牛乳汁表面油脂的加工品。【性味】湿热，味甘。【功能主治】生湿生热，润肺止咳，补身肥体，润喉清音，补胃润肠，防腐愈伤，祛风止痒。主治干寒性或黑胆质性疾病，如肺燥干咳，体虚身瘦，咽干音哑，寒性胃虚，肠燥便秘，各种皮肤创伤，牛皮癣，头癣。
本发明与现有技术相比，具有以下有益效果：
1、本发明中药组合物具有和胃降逆、理气除湿、补胃润肠之功效，治疗渗出性皮肤病治愈率极高。本发明药材配伍升降并用，以通降为主，以达胃气下行而不致上逆。方中党参、白术、茯苓健脾益气以助理气，半夏、黄芩、蒲公英以健脾除湿、清热，柴胡、积壳、厚朴理气疏肝和胃，云扣莲、卤盐、奶皮温中补胃，共奏和胃降逆，理气除湿之效。
2、本发明中药组合物选用优质中药材制成，成本低廉且配伍相宜，符合中医药及现代医学研究理论，并利用现代医药制药技术制成，安全无毒副作用，达到标本兼治的目的，值得临床推广应用。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
实施例1
称取：党参15份、煅乌贼骨15份、茯苓8份、白术8份、法半夏8份、黄芩8份、枳壳8份、厚朴8份、柴胡8份、蒲公英8份、炙甘草6份、奶桃35份、炼山石6份、麦糵5份、云扣莲4份、卤盐5份、小叶锦鸡儿5份、奶皮4份，按以下工艺步骤进行制备：（1）将党参、茯苓、白术、法半夏、黄芩、枳壳、厚朴、柴胡、蒲公英、奶桃、炼山石、麦糵、云扣莲、小叶锦鸡儿洗净，放入容器内，加入8～10倍量的蒸馏水，浸泡5～6小时后，煮沸3～4小时，提取；再次加入6～8倍量蒸馏水，煮沸2～3小时，提取；最后，加入4～6倍量蒸馏水，加热煮沸1～2小时，提取；合并三次提取液，过滤，得滤液，浓缩成60℃下相对密度为1.10～1.16的稠膏，备用；（2）将煅乌贼骨和炙甘草进行混合，混合均匀后进行粉碎处理，研末，过160目细粉，备用；（3）将卤盐、奶皮放入容器内，加入黄酒，并加入少量蜂蜜，搅拌均匀，经容器密封，隔水加热15～25min，取出，得膏体备用；（4）将上述步骤（1）～（3）所制得的稠膏、细粉以及膏体混合，制成胶囊剂。
用法用量：口服，每日2次，早晚各1次，每次1粒，饭后温开水送服；30天为1个疗程，连续服用2个疗程。
实施例2
称取：党参15份、煅乌贼骨15份、茯苓8份、白术8份、法半夏8份、黄芩8份、枳壳8份、厚朴8份、柴胡8份、蒲公英8份、炙甘草6份、奶桃35份、麦糵5份、云扣莲4份、奶皮4份。
本实施例的中药组合物制备方法与实施例1相同。
实施例3
称取：党参16份、煅乌贼骨16份、茯苓9份、白术9份、法半夏9份、黄芩9份、枳壳9份、厚朴9份、柴胡9份、蒲公英9份、炙甘草7份、奶桃40份、炼山石7份、麦糵6份、云扣莲5份、卤盐6份、小叶锦鸡儿6份、奶皮5份。
本实施例的中药组合物制备方法与实施例1相同。
临床资料：
1、病例选择：
作为治疗渗出性皮肤病的中药组合物，选择2010年以来诊治的渗出性皮肤病患者38例临床观察。患者均符合《中医内科学》关于渗出性皮肤病的诊断标准，可以确诊为渗出性皮肤病。
2、药物选择：
服用本发明实施例1所制得的中药胶囊制剂，口服，每日2次，早晚各1次，每次1粒，饭后温开水送服；30天为1个疗程，连续服用2个疗程。
3、疗效判定：
（1）治愈：症状及体征消失，X线钡餐及(或)纤维胃镜检查粘膜恢复正常。
（2）好转：症状及体征减轻，X线钡餐及(或)纤维胃镜检查病变有改善。
（3）未愈：症状及体征无减轻，X线钡餐及(或)纤维胃镜检查无变化。
4、结果：
选用本发明实施例1中药胶囊的治疗组中，治愈29例，好转9例，未愈0例，治愈率76.3%，总有效率100%。
以上结果显示，本发明对于治疗渗出性皮肤病有良效。
5、典型病例：
黎某，男，66岁。近两月逐渐出现胸骨后不适，偶有灼痛，泛酸，呃逆，伴咯痰。经医学检验，确诊为反流性食管炎。指导其服用本发明实施例1所制胶囊，口服，每日2次，早晚各1次，每次1粒，饭后温开水送服。连续服用7天后，症状及体征明显减轻，X线钡餐及(或)纤维胃镜检查病变有明显改善。再连续服用10天后，症状及体征消失，X线钡餐及(或)纤维胃镜检查粘膜恢复正常。
显然，本发明的上述实施例仅仅是为清楚地说明本发明所作的举例，而并非是对本发明的实施方式的限定。对于所属领域的普通技术人员来说，在上述说明的基础上还可以做出其它不同形式的变化或变动。这里无法对所有的实施方式予以穷举。凡是属于本发明的技术方案所引伸出的显而易见的变化或变动仍处于本发明的保护范围之列。

Claims (4)

1.一种治疗渗出性皮肤病的中药组合物，其特征在于，由以下重量配比的药材制备而成：党参15～16份、煅乌贼骨15～16份、茯苓8～9份、白术8～9份、法半夏8～9份、黄芩8～9份、枳壳8～9份、厚朴8～9份、柴胡8～9份、蒲公英8～9份、炙甘草6～7份、奶桃35～40份、炼山石0～7份、麦糵5～6份、云扣莲4～5份、卤盐0～6份、小叶锦鸡儿0～6份、奶皮4～5份。
2.根据权利要求1所述的一种治疗渗出性皮肤病的中药组合物，其特征在于，由以下重量配比的药材制备而成：党参15～16份、煅乌贼骨15～16份、茯苓8～9份、白术8～9份、法半夏8～9份、黄芩8～9份、枳壳8～9份、厚朴8～9份、柴胡8～9份、蒲公英8～9份、炙甘草6～7份、奶桃35～40份、炼山石6～7份、麦糵5～6份、云扣莲4～5份、卤盐5～6份、小叶锦鸡儿5～6份、奶皮4～5份。
3.根据权利要求1所述的一种治疗渗出性皮肤病的中药组合物，其特征在于，由以下重量配比的药材制备而成：党参15份、煅乌贼骨15份、茯苓8份、白术8份、法半夏8份、黄芩8份、枳壳8份、厚朴8份、柴胡8份、蒲公英8份、炙甘草6份、奶桃35份、炼山石6份、麦糵5份、云扣莲4份、卤盐5份、小叶锦鸡儿5份、奶皮4份。
4.一种治疗渗出性皮肤病的中药组合物的制备方法，其特征在于，包括如下步骤：（1）将党参、茯苓、白术、法半夏、黄芩、枳壳、厚朴、柴胡、蒲公英、奶桃、炼山石、麦糵、云扣莲、小叶锦鸡儿洗净，放入容器内，加入8～10倍量的蒸馏水，浸泡5～6小时后，煮沸3～4小时，提取；再次加入6～8倍量蒸馏水，煮沸2～3小时，提取；最后，加入4～6倍量蒸馏水，加热煮沸1～2小时，提取；合并三次提取液，过滤，得滤液，浓缩成60℃下相对密度为1.10～1.16的稠膏，备用；（2）将煅乌贼骨和炙甘草进行混合，混合均匀后进行粉碎处理，研末，过160目细粉，备用；（3）将卤盐、奶皮放入容器内，加入黄酒，并加入少量蜂蜜，搅拌均匀，经容器密封，隔水加热15～25min，取出，得膏体备用；（4）将上述步骤（1）～（3）所制得的稠膏、细粉以及膏体混合，制成胶囊剂。
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CN104474386A (zh) * 2014-11-30 2015-04-01 黄根强 一种治疗返流性食道炎的中药组合物

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Publication number Priority date Publication date Assignee Title
US20040258676A1 (en) * 2003-06-13 2004-12-23 Coletica Stimulation of the activity of an isoform of lysyl oxidase for combating against some pathologies due to an incomplete, absent or disorganized elastogenesis
CN104069414A (zh) * 2014-06-23 2014-10-01 天长市中医院 一种舒胃药物组合物及其用途
CN104474386A (zh) * 2014-11-30 2015-04-01 黄根强 一种治疗返流性食道炎的中药组合物

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