CN104491462A - Medicine composition used for treating burns and scalds - Google Patents

Medicine composition used for treating burns and scalds Download PDF

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Publication number
CN104491462A
CN104491462A CN201510021121.9A CN201510021121A CN104491462A CN 104491462 A CN104491462 A CN 104491462A CN 201510021121 A CN201510021121 A CN 201510021121A CN 104491462 A CN104491462 A CN 104491462A
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medicine composition
scald
rhizoma
bletillae
scalds
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CN201510021121.9A
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CN104491462B (en
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王生学
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Lu Yan
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/739—Sanguisorba (burnet)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718—Coptis (goldthread)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention belongs to the field of pharmacy, and relates to a medicine composition used for treating burns and scalds and a preparation method of the medicine composition. The medicine composition is obtained by improving a traditional Chinese medicine formula used for treating burns and scalds. Particularly, the medicine composition is prepared through eight types of traditional Chinese medicine including garden burnet, rhizoma bletillae, yellow cinnamon leaves, trichosanthes palmate, moutan bark, field thistle, coptis chinensis and borneol. Compared with the traditional Chinese medicine used for treating burns and scalds, the medicine composition has the advantages of being simple in preparation process, convenient to use, rapid in pain relieving after being taken, high in effect taking speed, good in effect and not capable of leaving scars after the burns and the scalds are cured.

Description

A kind of pharmaceutical composition for the treatment of scald
Technical field
The invention belongs to tcm field, relate to one and treat scald medicament compositions, being specifically related to a kind of take Chinese herbal medicine as the pharmaceutical composition of key component.
Background technology
Scald is called by the caused damage such as high-temp liquid, high-temp solid or high-temperature vapour.Scald and be generally divided into Three Estate: first degree scald (erythematous, erythrosis), two degree of scalds (vesiculovirus, affected part produces blister), three degree of scalds (gangrenosum acne, skin is cut).The treatment of current scald is mainly based on Western medicine, and its course for the treatment of is long, easy scar more.
Summary of the invention
One is the object of the present invention is to provide to treat scald medicament compositions.
It is improve on the basis of traditional treatment burn and scald medicine that the present invention treats scald medicament compositions, inventor finds through long-term clinical experiment, by in traditional burn and scald Chinese medicine compound of being made up of Radix Sanguisorbae, Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Polygoni Cuspidati, Caulis Lonicerae, Rhizoma Coptidis, Borneolum Syntheticum 5 etc. Rhizoma Polygoni Cuspidati, Caulis Lonicerae etc. two taste medical material remove, after being changed to the four taste Chinese crude drugs such as Folium Cinnamomi porrecti, Radix Stephaniae Cepharanthae, Cortex Moutan, Herba Cirsii, the effect of its treatment burn and scald there occurs significant change.
Particularly, the present invention treats scald medicament compositions, is formed by 8 kinds of Chinese drug preparations such as Radix Sanguisorbae, Pseudobulbus Bletillae (Rhizoma Bletillae), Folium Cinnamomi porrecti, Radix Stephaniae Cepharanthae, Cortex Moutan, Herba Cirsii, Rhizoma Coptidis, Borneolum Syntheticums.
Preferably, the present invention treats scald medicament compositions and is formed by the Chinese drug preparation of following weight portion:
Radix Sanguisorbae 24-48, Pseudobulbus Bletillae (Rhizoma Bletillae) 24-48, Folium Cinnamomi porrecti 24-48, Radix Stephaniae Cepharanthae 12-30, Cortex Moutan 12-30, Herba Cirsii 5-25, Rhizoma Coptidis 4-12, Borneolum Syntheticum 0.2-1.
As concrete optimal technical scheme, the present invention treats scald medicament compositions and is formed by the Chinese drug preparation of following weight portion:
Radix Sanguisorbae 30, Pseudobulbus Bletillae (Rhizoma Bletillae) 30, Folium Cinnamomi porrecti 30, Radix Stephaniae Cepharanthae 16, Cortex Moutan 16, Herba Cirsii 10, Rhizoma Coptidis 6, Borneolum Syntheticum 0.4.
The present invention treats the preparation method of scald medicament compositions, comprises the following steps:
Take Radix Sanguisorbae, Pseudobulbus Bletillae (Rhizoma Bletillae), Folium Cinnamomi porrecti, Radix Stephaniae Cepharanthae, Cortex Moutan, Herba Cirsii, Rhizoma Coptidis, Borneolum Syntheticum, drying and crushing crosses 100-200 mesh sieve, gained medicated powder, by the weight mix homogeneously of prescription of the present invention, namely obtains the present invention through sterilizing, subpackage and treats scald medicament compositions.
Using method of the present invention is as follows:
Get appropriate medicated powder of the present invention, reconcile into pasty state with Ovum Gallus domesticus album or Oleum Sesami, apply on wound surface, thickness 0.2-0.5cm, cover sterile cotton, then with sterile gauze wrapping, specifically change dressings, medication natural law determines according to scalding the degree in face and concrete condition.
The present invention compared with prior art tool has the following advantages:
The present invention treats scald medicament compositions compared with the Chinese medicine of traditional treatment burn and scald, and preparation technology is simple, easy to use, and after medication, pain relieving is rapid, and curative effect is fast, effective, to less than II degree and II degree burned patient, does not stay the advantage of cicatrix after having healing.For III burn and scald, after using medicine of the present invention, granulation tissue and epithelial tissue ramp can be made, flap coverage and without the need to skin-grafting.
Clinical report is as follows:
1, physical data
Outpatient service and burned patient 184 example of being in hospital, wherein I degree burn and scald 55 example, light degree Ⅱ burn and scald 80 example, dark II degree of burn and scald 49 example.Be divided into two groups at random: treatment group and each 92 examples of matched group.Wherein treatment group I degree burn and scald 27 example, light degree Ⅱ burn and scald 40 example, dark II degree of burn and scald 25 example.Matched group I degree burn and scald 28 example, light degree Ⅱ burn and scald 40 example, dark II degree of burn and scald 24 example.At two groups of ages, sex, the comparing differences such as symptom are without significance (P > 0.05).
2, diagnostic criteria
There are clear and definite boiling water, flame equivalent damage Shi Kecha.
I degree: slightly red, swollen, hot, bitterly, hyperesthesia, does not get blister, epidermis is dry;
Light degree Ⅱ: severe pain, hyperesthesia, temperature increases, and has vesicle, and substrate is moist, and in evenly red, vesicle is obvious.
Dark II degree: hypalgesia, vesicle is with little or no, throws off epidermis, and substrate drying is pale, and have little petechia, edema is obvious.
3, Therapeutic Method
3.1 treatment groups:
Medicine:
Take Radix Sanguisorbae 30g, Pseudobulbus Bletillae (Rhizoma Bletillae) 30g, Folium Cinnamomi porrecti 30g, Radix Stephaniae Cepharanthae 16g, Cortex Moutan 16g, Herba Cirsii 10g, Rhizoma Coptidis 6g, Borneolum Syntheticum 0.4g, drying and crushing crosses 150 mesh sieves, by gained medicated powder mix homogeneously, through sterilizing, get appropriate medicated powder Ovum Gallus domesticus album and reconcile into pasty state, for subsequent use.
Therapeutic Method: the direct drug of topical application of the fresh pollution-free wound surface of burn and scald; Have the wound surface of pollution, remove foreign body, with normal saline flushing, sterile gauze dips in solid carbon dioxide and divides, and then medicine is spread on wound surface; Drug of topical application thickness 0.2-0.5cm, covers sterile cotton, then wraps up with sterile gauze, and morning, noon and afternoon every day respectively change dressings once.Continuous treatment 4 days.
3.2 matched groups:
Medicine: burn liquid for treatment of skin disease.Effective ingredient is Radix Sanguisorbae, Rhizoma Polygoni Cuspidati, Pseudobulbus Bletillae (Rhizoma Bletillae), Caulis Lonicerae, Rhizoma Coptidis, Borneolum Syntheticum.
Therapeutic Method: dip medicinal liquid with sterilized cotton ball, is applied to clean wound surface or affected part gently, 3 times on the one.Continuous treatment 4 days.
4, efficacy assessment standard:
Cure: General Symptoms disappears, wound healing;
Take a turn for the better: General Symptoms disappears, and wound surface does not heal completely;
Do not heal: General Symptoms has no improvement, traumatic infection can not control.
5 therapeutic outcomes
5.1 liang of group pain disappearing times and average healing days compare, see table 1.
Table 1 liang group pain disappearing time and average healing days
Group Number of cases Pain disappearing time (h) Average healing days (my god)
Treatment group 92 22.2±15.8 * 6.9±3.2 *
Matched group 92 42.3±14.9 13.0±4.2
Remarks: *compare with matched group, P < 0.01.
Experimental result shows, and pharmaceutical composition of the present invention is at average pain extinction time, and average healing days aspect is significantly better than matched group, has pole significant difference.Visible pharmaceutical composition of the present invention analgesic effect compared with conventional medicament compositions is better, and healing time is short.
5.2 treatments are after one week, and two groups of comparitive study, see table 2
Table 2 liang group comparitive study
Group Number of cases Cure Take a turn for the better Do not heal Total effective rate
Treatment group 92 82(89.1％) # 10(10.9％) 0 100％ #
Matched group 92 60(65.2％) 17(18.5％) 15(16.3％) 83.7％
Remarks: #compare with matched group, P < 0.01.
Experimental result shows, pharmaceutical composition of the present invention no matter cure rate or total effective rate is all significantly higher than matched group.
After 50 days, treatment group is cured patient none example and is left obvious cicatrix, and matched group is cured patient and had 14 examples to leave cicatrix in various degree.Visible pharmaceutical composition of the present invention is compared Chinese medicine prescription and is had the advantage of curing rear preventing from scar.
Detailed description of the invention
The embodiment of the present invention only in order to technical scheme of the present invention to be described, is not intended to limit.
EXAMPLE l
Prescription (weight portion):
Radix Sanguisorbae 24, Pseudobulbus Bletillae (Rhizoma Bletillae) 24, Folium Cinnamomi porrecti 24, Radix Stephaniae Cepharanthae 12, Cortex Moutan 12, Herba Cirsii 5, Rhizoma Coptidis 4, Borneolum Syntheticum 0.2.
Preparation method:
Take the Radix Sanguisorbae of above-mentioned weight portion, Pseudobulbus Bletillae (Rhizoma Bletillae), Folium Cinnamomi porrecti, Radix Stephaniae Cepharanthae, Cortex Moutan, Herba Cirsii, Rhizoma Coptidis, Borneolum Syntheticum, drying and crushing crosses 200 mesh sieves, gained medicated powder mix homogeneously, namely obtains the present invention treat scald medicament compositions through sterilizing, subpackage.
Embodiment 2
Prescription (weight portion):
Radix Sanguisorbae 30, Pseudobulbus Bletillae (Rhizoma Bletillae) 30, Folium Cinnamomi porrecti 30, Radix Stephaniae Cepharanthae 16, Cortex Moutan 16, Herba Cirsii 10, Rhizoma Coptidis 6, Borneolum Syntheticum 0.4.
Preparation method:
Take the Radix Sanguisorbae of above-mentioned weight portion, Pseudobulbus Bletillae (Rhizoma Bletillae), Folium Cinnamomi porrecti, Radix Stephaniae Cepharanthae, Cortex Moutan, Herba Cirsii, Rhizoma Coptidis, Borneolum Syntheticum, drying and crushing crosses 150 mesh sieves, gained medicated powder mix homogeneously, namely obtains the present invention treat scald medicament compositions through sterilizing, subpackage.
Embodiment 3
Prescription (weight portion):
Radix Sanguisorbae 48, Pseudobulbus Bletillae (Rhizoma Bletillae) 36, Folium Cinnamomi porrecti 32, Radix Stephaniae Cepharanthae 24, Cortex Moutan 18, Herba Cirsii 12, Rhizoma Coptidis 12, Borneolum Syntheticum 0.8.
Preparation method:
Take the Radix Sanguisorbae of above-mentioned weight portion, Pseudobulbus Bletillae (Rhizoma Bletillae), Folium Cinnamomi porrecti, Radix Stephaniae Cepharanthae, Cortex Moutan, Herba Cirsii, Rhizoma Coptidis, Borneolum Syntheticum, drying and crushing crosses 150 mesh sieves, gained medicated powder mix homogeneously, namely obtains the present invention treat scald medicament compositions through sterilizing, subpackage.

Claims (4)

1. treat a Chinese medicine composition for scald, it is characterized in that being formed by 8 kinds of Chinese drug preparations such as Radix Sanguisorbae, Pseudobulbus Bletillae (Rhizoma Bletillae), Folium Cinnamomi porrecti, Radix Stephaniae Cepharanthae, Cortex Moutan, Herba Cirsii, Rhizoma Coptidis, Borneolum Syntheticums.
2. the Chinese medicine composition for the treatment of scald according to claim 1, is characterized in that being formed by the Chinese drug preparation of following weight portion:
Radix Sanguisorbae 24-48, Pseudobulbus Bletillae (Rhizoma Bletillae) 24-48, Folium Cinnamomi porrecti 24-48, Radix Stephaniae Cepharanthae 12-30, Cortex Moutan 12-30, Herba Cirsii 5-25, Rhizoma Coptidis 4-12, Borneolum Syntheticum 0.2-1.
3. the Chinese medicine composition for the treatment of scald according to claim 2, is characterized in that being formed by the Chinese drug preparation of following weight portion:
Radix Sanguisorbae 30, Pseudobulbus Bletillae (Rhizoma Bletillae) 30, Folium Cinnamomi porrecti 30, Radix Stephaniae Cepharanthae 16, Cortex Moutan 16, Herba Cirsii 10, Rhizoma Coptidis 6, Borneolum Syntheticum 0.4.
4. a preparation method for the Chinese medicine composition that the treatment as described in as arbitrary in claim 1-3 is scalded, is characterized in that, comprise the following steps:
Take Radix Sanguisorbae, Pseudobulbus Bletillae (Rhizoma Bletillae), Folium Cinnamomi porrecti, Radix Stephaniae Cepharanthae, Cortex Moutan, Herba Cirsii, Rhizoma Coptidis, Borneolum Syntheticum, drying and crushing crosses 100-200 mesh sieve, gained medicated powder, by the weight mix homogeneously of prescription of the present invention, namely obtains the present invention through sterilizing, subpackage and treats scald medicament compositions.
CN201510021121.9A 2015-01-16 2015-01-16 A kind of pharmaceutical composition for the treatment of scald Expired - Fee Related CN104491462B (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105267452A (en) * 2015-11-04 2016-01-27 原慧玲 Traditional Chinese medicine composition for treating scald

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104116925A (en) * 2014-08-12 2014-10-29 杨闽 Novel burn oil for treating burns and scalds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104116925A (en) * 2014-08-12 2014-10-29 杨闽 Novel burn oil for treating burns and scalds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
李萍等: "HPLC法测定烧伤肤康液中虎杖苷的含量", 《中国药事》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105267452A (en) * 2015-11-04 2016-01-27 原慧玲 Traditional Chinese medicine composition for treating scald

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