CN104491456A - 风湿性膝关节炎除痹通络膏及制备 - Google Patents
风湿性膝关节炎除痹通络膏及制备 Download PDFInfo
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Abstract
本发明公开了风湿性膝关节炎除痹通络膏,主要由下列原料药制备而成,均为重量份:忍冬藤8-15;黄连4-8;红孩儿9-12;繁缕9-16;鲜地黄10-16;九子连环草8-12;马钱子9-15;风藤草9-16;接骨草8-12;大散血8-12;丝瓜藤10-18;山紫菀8-12;古羊藤6-9。本发明提供的制剂效果显著、见效快、治愈率高。
Description
技术领域
本发明涉及中医中药领域,特别是涉及风湿性膝关节炎除痹通络膏及制备。
背景技术
风湿性关节炎是一种常见的急性或慢性结缔组织炎症。可反复发作并累及心脏。临床以关节和肌肉游走性酸楚、重著、疼痛为特征。属变态反应性疾病。是风湿热的主要表现之一,多以急性发热及关节疼痛起病。典型表现是轻度或中度发热,游走性多关节炎,受累关节多为膝、踝、肩、肘、腕等大关节,常见由一个关节转移至另一个关节,病变局部呈现红、肿、灼热、剧痛,部分病人也有几个关节同时发病。不典型的病人仅有关节疼痛而无其他炎症表现,急性炎症一般于2~4周消退,不留后遗症,但常反复发作。若风湿活动影响心脏,则可发生心肌炎,甚至遗留心脏瓣膜病变。
公布号CN 102363037 A(申请号201110337926.6)的中国专利文献公开了一种治疗风湿、类风湿性关节炎和颈肩腰腿疼的外用膏药,膏药中的药剂采用马钱子、川乌、草乌、土元、肉桂、白芥子、荜拨、三七、乳香、没药、血竭、细辛、全虫、蜈蚣、乌梢蛇、白花蛇、地龙、公丁香、威灵仙、干姜、当归、川芎、红花、透骨草、寻骨风、青风藤、海风藤、鸡血藤、羌活、独活、秦艽、防风、骨碎补、三棱、莪术、桂枝、元胡、冰片、樟脑多种药物配制,用芝麻油、广丹配制而成。公布号CN 102397523 A(申请号201110382694.6)的中国专利文献公开了一种用于治疗风湿、类风湿性关节炎和颈肩腰腿疼的药物,该药由内服丸药和外洗药组成,内服丸药是由地龙,蜂房,乌梢蛇,全虫,蜈蚣,白花蛇,三七,乳香,没药,血竭,细辛,肉桂,威灵仙,干姜,当归,川芎,红花,透骨草,寻骨风,鸡血藤,羌活,独活,秦艽,防风,骨碎,桂枝,元胡,金银花,熟地,杜仲,甘草制成;外洗药是由透骨草,寻骨风,威灵仙,海桐皮,路路通,桑枝,花椒,艾叶,桂枝,红花,川乌,草乌,赤芍,青风藤,海风藤,丁香,白芷制成。
现代医学中,中医所采用的治疗方案,相比较于西医常用的消炎镇痛和免疫抑制剂药物,更加安全有效,但是部分中医配方存在缺陷,导致药效不明显,所以还需进一步的加强对该方面中药的研究。
发明内容
针对现有技术的问题,本发明的目的是提供一种效果显著、服用安全适用性广的风湿性膝关节炎除痹通络膏。
本发明的技术方案是:
风湿性膝关节炎除痹通络膏,主要由下列原料药制备而成,均为重量份:忍冬藤8-15;黄连4-8;红孩儿9-12;繁缕9-16;鲜地黄10-16;九子连环草8-12;马钱子9-15;风藤草9-16;接骨草8-12;大散血8-12;丝瓜藤10-18;山紫菀8-12;古羊藤6-9。
优选的是:忍冬藤10-13;黄连5-7;红孩儿10-11;繁缕11-14;鲜地黄12-14;九子连环草9-11;马钱子11-13;风藤草11-14;接骨草9-11;大散血9-11;丝瓜藤12-16;山紫菀9-11;古羊藤7-8。
更加优选的是:忍冬藤11.5;黄连6;红孩儿10.5;繁缕12.5;鲜地黄13;九子连环草10;马钱子12;风藤草12.5;接骨草10;大散血10;丝瓜藤14;山紫菀10;古羊藤7.5。
所述的风湿性膝关节炎除痹通络膏的制备方法,其步骤如下:
(1)取炼蜜,加入开水稀释,淋入洗净的忍冬藤中,拌匀闷润,置于炒制容器内,用文火加热,炒至老黄色,不黏手时,取出晾凉、粉碎过筛;
(2)将丝瓜藤和鲜地黄洗净,除去杂质,切薄片后加入乙醇浸泡30-50分钟(优选的:浸泡35-45分钟;更加优选的:浸泡40分钟),倒入研钵中捣碎,用纱布挤压榨取汁液过滤;
(3)取马钱子洗净,置于砂锅内,加入牛奶蒸煮15-25分钟(优选的:蒸煮20分钟),取出去皮,再用麻油炸呈黄色,沥干并碾碎成粉;
(4)将黄连、红孩儿、风藤草、山紫菀和古羊藤,加水浸泡40-60分钟(优选的:加水浸泡45-55分钟;更加优选的:加水浸泡50分钟),加热15分钟后,再加入繁缕、九子连环草、接骨草和大散血,大火煮沸后转小火煎煮,趁热过滤,收集滤液;
(5)混合上述步骤所得药粉、汁液和滤液,加热浓缩成清膏,加入辅料蔗糖,搅拌均匀、封装得除痹通络膏。
所述的风湿性膝关节炎除痹通络膏的制备方法,步骤(1)中粉碎过80-110目筛(优选的:粉碎过90-100目筛;更加优选的:粉碎过95目筛)。
所述的风湿性膝关节炎除痹通络膏的制备方法,步骤(2)乙醇浓度为50%-70%(优选的:乙醇浓度为60%)。
所述的风湿性膝关节炎除痹通络膏的制备方法,步骤(3)中牛奶量为药材重量的6-9倍(优选的:牛奶量为药材重量的7-8倍;更加优选的:牛奶量为药材重量的7.5倍)。
所述的风湿性膝关节炎除痹通络膏的制备方法,步骤(4)中加水量为药材重量的7-10倍(优选的:加水量为药材重量的8-9倍;更加优选的:加水量为药材重量的8.5倍)。
所述的风湿性膝关节炎除痹通络膏的制备方法,步骤(4)中小火煎煮35-55分钟(优选的:小火煎煮40-50分钟;更加优选的:小火煎煮45分钟)。
所述的风湿性膝关节炎除痹通络膏的制备方法,步骤(5)中辅料蔗糖的量为清膏重量的0.4-0.6倍(优选的:辅料蔗糖的量为清膏重量的0.5倍)。
本发明提供的风湿性膝关节炎除痹通络膏配方科学,制备方法简单。除此之外,它的优良之处还表现在:
1、本发明所得药物针对风湿性膝关节炎,疗效显著、治愈率高;
2、本发明组方配伍严谨、根据多年临床经验,反复实验而得;
3、组方所选用的药物有祛风除湿、舒筋活络的功效,迅速改善身体不适症。
具体实施方式
下面结合实施例和实验例详细说明本发明的技术方案,但保护范围不限于此。
本发明所用主要中药原料的药理如下:
忍冬藤:基原:为忍冬科植物忍冬的茎叶。化学成份:叶含忍冬甙即木犀草素-7-鼠李糖葡萄糖甙、木犀草素等黄酮类。茎含鞣质、生物碱。性味:甘,寒。归经:入心、肺经。功能主治:清热,解毒,通络。治温病发热,热毒血痢,传染性肝炎,痈肿疮毒,筋骨疼痛。
黄连:基原:为毛茛科植物黄连、三角叶黄连、峨嵋野连或云南黄连的根茎。化学成份:黄连含小檗碱7~9%、黄连碱,甲基黄连碱、掌叶防已碱、非洲防己碱等生物碱,尚含黄柏酮、黄柏内酯。性味:苦,寒。归经:入心、肝、胃、大肠经。功能主治:泻火,燥湿,解毒,杀虫。治时行热毒,伤寒,热盛心烦,痞满呕逆,菌痢,热泻腹痛,肺结按,吐、衄、下血,消渴,疳积,蛔虫病,百日咳,咽喉肿痛,火眼,口疮,痈疽疮毒,湿疹,汤火烫伤。
红孩儿:基原:为秋海棠科植物裂叶秋海棠的全株。全年可采,洗净,晒干。性味:《陆川本草》:"甘,寒。"功能主治:治感冒咳嗽,风湿骨痛,腰痛,消化不良,跌打肿痛,疔疮。
繁缕:别名 鹅儿肠、鸡肠菜、合筋草、小被单草、园酸菜。基原:石竹科繁缕属植物繁缕,以全草入药。夏秋采,晒干或鲜用。性味:甘、酸,凉。功能主治:清热解毒,化瘀止痛,催乳。用于肠炎,痢疾,肝炎,阑尾炎,产后瘀血腹痛,子宫收缩痛,牙痛,头发早白,乳汁不下,乳腺炎,跌打损伤,疮疡肿毒。
鲜地黄:基原:为玄参科植物地黄的新鲜根茎。性味:甘苦,寒。归经:入心、肝、肾经。功能主治:清热,凉血,生津。治温病伤阴,大热烦渴,舌绛,神昏,斑疹,吐血,衄血,虚劳骨蒸,咳血,消渴,便秘,血崩。
九子连环草:基原:为兰科虾脊兰属植物虾脊兰的全草或根茎。成分:新鲜根茎含吲哚类及其糖苷:虾脊兰苷A、B,二氢菲衍生物,β-吲哚葡萄糖苷,虾脊兰菲醇,琉球虾脊兰苷;吲哚类生物碱类:色胺酮,靛玉红等。药性:辛、微苦,微寒。功用主治:清热解毒,活血止痛。主治痈肿,咽喉肿痛,痔疮,风湿痹痛,跌打损伤。
马钱子:基原:为马钱科植物马钱的成熟种子。果实成熟时采摘,除去果肉,取出种子,晒干。化学成份:含番木鳖碱、马钱子碱、α-及β-可鲁勃、番木鳖次碱、马钱子新碱、依卡精、番木鳖甙等。性味:苦,寒,有毒。功能主治:散血热,消肿,止痛。治咽喉痹痛,痈疽肿毒,风痹疼痛,骨折。并治面神经麻痹,重症肌无力。通络止痛,散结消肿。用于风湿顽痹、麻木瘫痪、跌扑损伤、痈疽肿痛。
风藤草:基原:为毛茛科植物钝萼铁线莲的藤茎和叶。性味:味苦;苦;性凉。归经:肺,脾经。功能主治:祛风清热;和络止痛。主风湿关节痛;风疹瘙痒;疮疥;肿毒;火眼疼痛;及小便不利。
接骨草:基原:为荨麻科植物庐山楼梯草的根茎或全草。春至秋季采集全草或根茎,多鲜用。性味:①《浙江天目山药植志》:"性温,味辛苦。"功能主治:活血散瘀,消肿止咳。治跌打扭伤,痄腮,闭经,咳嗽。
大散血:基原:为报春花科植物小前的全草。化学成份:全草含有芸香甙,金丝桃甙,山奈酚-3-O-芸香糖甙,水杨酸,6-十三烷基二羟基苯甲酸和银桦酚。 地上部分含山柰酚,槲皮素、β-谷甾醇和β-谷甾醇-β-D-葡萄糖甙。性味:甘;辛;性温功能主治:散瘀接骨。主跌打瘀肿;骨析。
丝瓜藤:基原:为葫芦科植物丝瓜或粤丝瓜的茎,夏、秋季采取。化学成份:丝瓜藤含皂甙。性味:《本草求原》:"苦,微寒,小毒。"归经:《本草再新》:"入心、脾、肾三经。"功能主治:舒筋,活血,健脾,杀虫。治腰膝四肢麻木,月经不调,水肿;齿露,鼻渊,牙宣。
山紫菀:基原:为菊科植物蹄叶橐吾的根及根茎。性味:味辛;性微温。功能主治:祛痰;止咳;理气活血;止痛。主咳嗽;普多气喘;百日咳;腰腿痛;劳伤;跌打损伤。
古羊藤:基原:为萝藦科马莲鞍属植物马连鞍的根。药性:甘,苦,凉。功用主治:1、清热解毒。治感冒发热,跌打淤积肿痛,腰腿酸痛,慢性肾炎;2、清热解毒,散瘀止痛。治肠炎,痢疾,胃痛,毒蛇咬伤。
实施例1风湿性膝关节炎除痹通络膏,主要由下列原料药制备而成:忍冬藤8g,黄连4g,红孩儿9g,繁缕9g,鲜地黄10g,九子连环草8g,马钱子9g,风藤草9g,接骨草8g,大散血8g,丝瓜藤10g,山紫菀8g,古羊藤6g。上述风湿性膝关节炎除痹通络膏的制备方法是:
(1)取炼蜜,加入开水稀释,淋入洗净的忍冬藤中,拌匀闷润,置于炒制容器内,用文火加热,炒至老黄色,不黏手时,取出晾凉、粉碎过80目筛;
(2)将丝瓜藤和鲜地黄洗净,除去杂质,切薄片后加入浓度50%的乙醇浸泡30分钟,倒入研钵中捣碎,用纱布挤压榨取汁液过滤;
(3)取马钱子洗净,置于砂锅内,加入药材重量6倍的牛奶蒸煮15分钟,取出去皮,再用麻油炸呈黄色,沥干并碾碎成粉;
(4)将黄连、红孩儿、风藤草、山紫菀和古羊藤,加入药材重量7倍的水浸泡40分钟,加热15分钟后,再加入繁缕、九子连环草、接骨草和大散血,大火煮沸后转小火煎煮35分钟,趁热过滤,收集滤液;
(5)混合上述步骤所得药粉、汁液和滤液,加热浓缩成清膏,加入清膏重量0.4倍的辅料蔗糖,搅拌均匀、封装得除痹通络膏。
实施例2风湿性膝关节炎除痹通络膏,主要由下列原料药制备而成:忍冬藤15g,黄连8g,红孩儿12g,繁缕16g,鲜地黄16g,九子连环草12g,马钱子15g,风藤草16g,接骨草12g,大散血12g,丝瓜藤18g,山紫菀12g,古羊藤9g。上述风湿性膝关节炎除痹通络膏的制备方法是:
(1)取炼蜜,加入开水稀释,淋入洗净的忍冬藤中,拌匀闷润,置于炒制容器内,用文火加热,炒至老黄色,不黏手时,取出晾凉、粉碎过110目筛;
(2)将丝瓜藤和鲜地黄洗净,除去杂质,切薄片后加入浓度70%的乙醇浸泡50分钟,倒入研钵中捣碎,用纱布挤压榨取汁液过滤;
(3)取马钱子洗净,置于砂锅内,加入药材重量9倍的牛奶蒸煮25分钟,取出去皮,再用麻油炸呈黄色,沥干并碾碎成粉;
(4)将黄连、红孩儿、风藤草、山紫菀和古羊藤,加入药材重量10倍的水浸泡60分钟,加热15分钟后,再加入繁缕、九子连环草、接骨草和大散血,大火煮沸后转小火煎煮55分钟,趁热过滤,收集滤液;
(5)混合上述步骤所得药粉、汁液和滤液,加热浓缩成清膏,加入清膏重量0.6倍的辅料蔗糖,搅拌均匀、封装得除痹通络膏。
典型病例:xxx,男性,51岁。主诉:由于长期在寒冷地区工作,导致膝关节阵发性疼痛6年,每当受凉,病情加重,服用止痛药,能暂时缓解疼痛,但病情反复,近日受凉,膝关节疼痛,肿胀、活动受限,肢体麻木、无力,遂来就诊,检查时,舌质红,苔薄白,脉弦,确诊风湿性膝关节炎。
经医生介绍服用本实例所得除痹通络膏,每次5g,一天三次,温开水冲服,十五天为一个疗程,服用两个疗程后,膝关节疼痛、肿胀有所减轻,活动功能稍有恢复,服用三个疗程后,不适症基本消除,巩固疗效一个疗程,两年内随访,患者未复发。
实施例3风湿性膝关节炎除痹通络膏,主要由下列原料药制备而成:忍冬藤10g,黄连5g,红孩儿10g,繁缕11g,鲜地黄12g,九子连环草9g,马钱子11g,风藤草11g,接骨草9g,大散血9g,丝瓜藤12g,山紫菀9g,古羊藤7g。上述风湿性膝关节炎除痹通络膏的制备方法是:
(1)取炼蜜,加入开水稀释,淋入洗净的忍冬藤中,拌匀闷润,置于炒制容器内,用文火加热,炒至老黄色,不黏手时,取出晾凉、粉碎过90目筛;
(2)将丝瓜藤和鲜地黄洗净,除去杂质,切薄片后加入浓度60%的乙醇浸泡35分钟,倒入研钵中捣碎,用纱布挤压榨取汁液过滤;
(3)取马钱子洗净,置于砂锅内,加入药材重量7倍的牛奶蒸煮20分钟,取出去皮,再用麻油炸呈黄色,沥干并碾碎成粉;
(4)将黄连、红孩儿、风藤草、山紫菀和古羊藤,加入药材重量8倍的水浸泡45分钟,加热15分钟后,再加入繁缕、九子连环草、接骨草和大散血,大火煮沸后转小火煎煮40分钟,趁热过滤,收集滤液;
(5)混合上述步骤所得药粉、汁液和滤液,加热浓缩成清膏,加入清膏重量0.5倍的辅料蔗糖,搅拌均匀、封装得除痹通络膏。
实施例4风湿性膝关节炎除痹通络膏,主要由下列原料药制备而成:忍冬藤13g,黄连7g,红孩儿11g,繁缕14g,鲜地黄14g,九子连环草11g,马钱子13g,风藤草14g,接骨草11g,大散血11g,丝瓜藤16g,山紫菀11g,古羊藤8g。上述风湿性膝关节炎除痹通络膏的制备方法是:
(1)取炼蜜,加入开水稀释,淋入洗净的忍冬藤中,拌匀闷润,置于炒制容器内,用文火加热,炒至老黄色,不黏手时,取出晾凉、粉碎过100目筛;
(2)将丝瓜藤和鲜地黄洗净,除去杂质,切薄片后加入浓度60%的乙醇浸泡45分钟,倒入研钵中捣碎,用纱布挤压榨取汁液过滤;
(3)取马钱子洗净,置于砂锅内,加入药材重量8倍的牛奶蒸煮20分钟,取出去皮,再用麻油炸呈黄色,沥干并碾碎成粉;
(4)将黄连、红孩儿、风藤草、山紫菀和古羊藤,加入药材重量9倍的水浸泡55分钟,加热15分钟后,再加入繁缕、九子连环草、接骨草和大散血,大火煮沸后转小火煎煮50分钟,趁热过滤,收集滤液;
(5)混合上述步骤所得药粉、汁液和滤液,加热浓缩成清膏,加入清膏重量0.5倍的辅料蔗糖,搅拌均匀、封装得除痹通络膏。
典型病例:xxx,女,55岁。一年前坐月子期间因淋雨受凉导致全身发热,膝关节疼痛,在当地医院诊断为风湿性膝关节炎,治疗一个月,发热现象消退,关节疼痛好转,但是每逢天气骤变,关节便开始疼痛,近期逐渐加重,遂来中医院治疗,检查发现膝关节未变形,无功能性障碍,活动时有声响。
服用本实例所得除痹通络膏,每次5g,温开水冲服,一天三次,十五天为一个疗程,患者服用两个疗程后,疼痛现象缓解,无其他不适症,继续巩固一个疗程后,基本痊愈,随访两年内,患者未出现复发。
实施例5风湿性膝关节炎除痹通络膏,主要由下列原料药制备而成:忍冬藤11.5g,黄连6g,红孩儿10.5g,繁缕12.5g,鲜地黄13g,九子连环草10g,马钱子12g,风藤草12.5g,接骨草10g,大散血10g,丝瓜藤14g,山紫菀10g,古羊藤7.5g。上述风湿性膝关节炎除痹通络膏的制备方法是:
(1)取炼蜜,加入开水稀释,淋入洗净的忍冬藤中,拌匀闷润,置于炒制容器内,用文火加热,炒至老黄色,不黏手时,取出晾凉、粉碎过95目筛;
(2)将丝瓜藤和鲜地黄洗净,除去杂质,切薄片后加入浓度60%的乙醇浸泡40分钟,倒入研钵中捣碎,用纱布挤压榨取汁液过滤;
(3)取马钱子洗净,置于砂锅内,加入药材重量7.5倍的牛奶蒸煮20分钟,取出去皮,再用麻油炸呈黄色,沥干并碾碎成粉;
(4)将黄连、红孩儿、风藤草、山紫菀和古羊藤,加入药材重量8.5倍的水浸泡50分钟,加热15分钟后,再加入繁缕、九子连环草、接骨草和大散血,大火煮沸后转小火煎煮45分钟,趁热过滤,收集滤液;
(5)混合上述步骤所得药粉、汁液和滤液,加热浓缩成清膏,加入清膏重量0.5倍的辅料蔗糖,搅拌均匀、封装得除痹通络膏。
试验例1 本发明所得风湿性膝关节炎除痹通络膏(实施例5)的临床应用:
选取人群:依据医院门诊病历,筛选风湿性膝关节炎患者388例,其中女性182例,男性206例,年龄范围18-60岁,病程半年以上。
试验前,将患者随机分为两组,实验组288例和对照组100例,两组在性别、年龄、病程、病情等方面无显著差异。实验组服用本发明所得除痹通络膏,每次5g,每天三次,温开水冲服,十五天为一个疗程;对照组服用其他常规药物(布洛芬、萘普生、双氯酚酸、阿司匹林等)。服药期间对两组患者进行连续观察,记录症状及变化。
疗效判定标准:参照文献疗效标准,治愈:膝关节红、肿、灼热、剧痛等完全消失,无其他临床不适症;显效:膝关节疼痛明显好转或消失,稍有肿胀,主要临床症状消失;有效:膝关节不适症状减轻,偶有发作,关节功能改善;无效:疼痛肿胀症状无任何改善。
临床结果:经三个疗程的服药后,使用本发明所得产品的实验组中,膝关节红肿、疼痛消失,无其他不适症的患者有192例(66.7%),膝关节疼痛明显好转的患者有51例(17.7%),膝关节不适症减轻的患者有37例(12.8%),可知实验组的总有效率为97.2%。对照组中治愈的患者有54例(54%),显效的患者有22例(22%),有效的患者有11例(11%),对照组的总有效率为87%。实验组所用产品疗效明显优于对照组,且治疗前后,实验组的患者身体状况较之前有显著提高。
本发明中所使用的中药,其中忍冬藤、红孩儿、繁缕、九子连环草、鲜地黄、古羊藤有清热解毒、通络镇痛的功效,黄连有泻火燥湿的功效,马钱子、风藤草、接骨草、大散血、丝瓜藤、山紫菀有消肿止痛、活血散瘀的功效,可有效缓解风湿性膝关节炎所带来的疼痛等不适症,从而提高治疗效果,使得总有效率可达到97.2%。
应当指出的是,具体实施方式只是本发明比较有代表性的例子,显然本发明的技术方案不限于上述实施例,还可以有很多变形。本领域的普通技术人员,以本发明所明确公开的或根据文件的书面描述毫无异议的得到的,均应认为是本专利所要保护的范围。
Claims (10)
1.风湿性膝关节炎除痹通络膏,其特征在于,主要由下列原料药制备而成,均为重量份:忍冬藤8-15;黄连4-8;红孩儿9-12;繁缕9-16;鲜地黄10-16;九子连环草8-12;马钱子9-15;风藤草9-16;接骨草8-12;大散血8-12;丝瓜藤10-18;山紫菀8-12;古羊藤6-9。
2. 如权利要求1所述的风湿性膝关节炎除痹通络膏,其特征在于,忍冬藤10-13;黄连5-7;红孩儿10-11;繁缕11-14;鲜地黄12-14;九子连环草9-11;马钱子11-13;风藤草11-14;接骨草9-11;大散血9-11;丝瓜藤12-16;山紫菀9-11;古羊藤7-8。
3.如权利要求1所述的风湿性膝关节炎除痹通络膏,其特征在于,忍冬藤11.5;黄连6;红孩儿10.5;繁缕12.5;鲜地黄13;九子连环草10;马钱子12;风藤草12.5;接骨草10;大散血10;丝瓜藤14;山紫菀10;古羊藤7.5。
4.如权利要求1-3任一所述的风湿性膝关节炎除痹通络膏的制备方法,其特征在于,步骤如下:
(1)取炼蜜,加入开水稀释,淋入洗净的忍冬藤中,拌匀闷润,置于炒制容器内,用文火加热,炒至老黄色,不黏手时,取出晾凉、粉碎过筛;
(2)将丝瓜藤和鲜地黄洗净,除去杂质,切薄片后加入乙醇浸泡30-50分钟(优选的:浸泡35-45分钟;更加优选的:浸泡40分钟),倒入研钵中捣碎,用纱布挤压榨取汁液过滤;
(3)取马钱子洗净,置于砂锅内,加入牛奶蒸煮15-25分钟(优选的:蒸煮20分钟),取出去皮,再用麻油炸呈黄色,沥干并碾碎成粉;
(4)将黄连、红孩儿、风藤草、山紫菀和古羊藤,加水浸泡40-60分钟(优选的:加水浸泡45-55分钟;更加优选的:加水浸泡50分钟),加热15分钟后,再加入繁缕、九子连环草、接骨草和大散血,大火煮沸后转小火煎煮,趁热过滤,收集滤液;
(5)混合上述步骤所得药粉、汁液和滤液,加热浓缩成清膏,加入辅料蔗糖,搅拌均匀、封装得除痹通络膏。
5.如权利要求4所述的风湿性膝关节炎除痹通络膏的制备方法,其特征在于,步骤(1)中粉碎过80-110目筛(优选的:粉碎过90-100目筛;更加优选的:粉碎过95目筛)。
6.如权利要求4所述的风湿性膝关节炎除痹通络膏的制备方法,其特征在于,步骤(2)乙醇浓度为50%-70%(优选的:乙醇浓度为60%)。
7.如权利要求4所述的风湿性膝关节炎除痹通络膏的制备方法,其特征在于,步骤(3)中牛奶量为药材重量的6-9倍(优选的:牛奶量为药材重量的7-8倍;更加优选的:牛奶量为药材重量的7.5倍)。
8.如权利要求4所述的风湿性膝关节炎除痹通络膏的制备方法,其特征在于,步骤(4)中加水量为药材重量的7-10倍(优选的:加水量为药材重量的8-9倍;更加优选的:加水量为药材重量的8.5倍)。
9.如权利要求4所述的风湿性膝关节炎除痹通络膏的制备方法,其特征在于,步骤(4)中小火煎煮35-55分钟(优选的:小火煎煮40-50分钟;更加优选的:小火煎煮45分钟)。
10.如权利要求4所述的风湿性膝关节炎除痹通络膏的制备方法,其特征在于,步骤(5)中辅料蔗糖的量为清膏重量的0.4-0.6倍(优选的:辅料蔗糖的量为清膏重量的0.5倍)。
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