CN104491390A - 一种防治放疗后副作用的中药组合物 - Google Patents

一种防治放疗后副作用的中药组合物 Download PDF

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CN104491390A
CN104491390A CN201410844057.XA CN201410844057A CN104491390A CN 104491390 A CN104491390 A CN 104491390A CN 201410844057 A CN201410844057 A CN 201410844057A CN 104491390 A CN104491390 A CN 104491390A
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刘武
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Qingdao Tumour Hospital
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Abstract

本发明属于中医中药技术领域，特别涉及一种防治放疗后副作用的中药组合物。由以下重量份数的原料配制而成：鸡血藤3～5份、沙参5～10份、莱菔子3～5份、旋复花1～2份、黄芪3～5份、石莲子3～5份、白花蛇舌草2～3份、当归3～5份、紫苏子3～5份、半枝莲3～5份、龙葵1～2份、天冬3～8份、麦冬3～8份、五味子2～3份、旱莲草3～8份、楮实子3～5份。制备方法是水煎剂。本发明通过中药的调理，补虚益气、健脾开胃、排毒利尿，适用于所有放疗后全身反应，有助于放疗后病人体力的恢复，加快体内毒素排出，减轻肿块焮热症状，增加白细胞数量，加快身体恢复。

Description

一种防治放疗后副作用的中药组合物
技术领域
本发明属于中医中药技术领域，特别涉及一种防治放疗后副作用的中药组合物。
背景技术
肿瘤放射治疗是利用放射线如放射性同位素产生的α、β、γ射线和各类x射线治疗机或加速器产生的x射线、电子线、质子束及其它粒子束等治疗恶性肿瘤的一种方法。因癌细胞的生长和分裂比他们周围许多的正常细胞都要快，故采用特殊设备产生的高剂量射线照射癌变的肿瘤，可杀死或破坏癌细胞，抑制它们的生长、繁殖和扩散。虽然一些正常细胞也会受到破坏，但是大多数都会恢复。
放疗术后由于肿瘤组织崩解、毒素被吸收，在照射数小时或1～2天后，病人可出现全身反应，表现为虚弱、乏力、头晕、头痛、厌食，个别有恶心、呕吐等，特别是腹部照射和大面积照射时，反应较重。术后措施一般为进清淡饮食、蔬菜和水果，并鼓励多饮水，促进毒素排出。但癌症病人一般体虚，单靠食物和饮水恢复速度慢，残留毒素增加病人的身体负担，不利于病人的快速康复。中国专利(CN101108002)公开了一种用于放疗调补的中药，能够一定程度的减轻放疗副作用，但只适用于放疗期间减轻放疗后粘膜反应，且不能辅助加快毒素排出，具有一定的局限性。
发明内容
本发明的目的是提供一种防治放疗后副作用的中药组合物，通过中药的调理，补虚益气、健脾开胃、排毒利尿，适用于所有放疗后全身反应，有助于放疗后病人体力的恢复，加快体内毒素排出，减轻肿块焮热症状，增加白细胞数量，加快身体恢复。
本发明提供一种防治放疗后副作用的中药组合物，由以下重量份数的原料配制而成：鸡血藤3～5份、沙参5～10份、莱菔子3～5份、旋复花1～2份、黄芪3～5份、石莲子3～5份、白花蛇舌草2～3份、当归3～5份、紫苏子3～5份、半枝莲3～5份、龙葵1～2份、天冬3～8份、麦冬3～8份、五味子2～3份、旱莲草3～8份、楮实子3～5份。
进一步优选为由以下重量份数的原料配制而成：鸡血藤4份、沙参7份、莱菔子4份、旋复花1份、黄芪4份、石莲子4份、白花蛇舌草2份、当归4份、紫苏子4份、半枝莲4份、龙葵1份、天冬5份、麦冬5份、五味子2份、旱莲草5份、楮实子4份。
制备方法是按上述重量份称取中药原料，加入冷水，没过药材2～5cm，浸泡1～2个小时；然后进行煎煮，先用武火煮开，煮开后转为文火熬煮20～40min；煮好后，滤出药汁作为头煎；将药渣重复上述步骤煎煮，煮好后，将两次煎煮的药汁合并即可。
药理分析：
鸡血藤：味苦微甘、性温，归肝、心、肾经；主治风湿痹痛，手足麻木，肢体瘫痪，月经不调，经行不畅，痛经，经闭，白细胞减少症。
沙参：味甘，微苦，性微寒；归肺，胃经。功能养阴清热，润肺化痰，益胃生津；主治阴虚久咳，痨嗽痰血，燥咳痰少，虚热喉痹，津伤口渴。
莱菔子：味辛、甘，性平，归脾、胃、肺经。功能消食除胀，降气化痰。主治食积停滞，脘腹胀痛，嗳气打嗝，大便秘结，泻痢后重，痰壅喘咳等。
旋复花：味咸，温；入肺、肝、胃经；主结气，胁下满，惊悸。除水，去五脏间寒热，补中，下气。
黄芪：味甘，性微温，归脾、肺经，入气分，可升可降。功效补气升阳，固表止汗，行水消肿，脱毒生肌。主治内伤劳倦，神疲乏力，脾虚泄泻，肺虚咳嗽，内脏下垂，脾不统血之出血，自汗，盗汗等。古籍《本草经》述：“补元阳，充腠理，治劳伤，长肌肉。”《本草汇言》曰：“补肺健脾，实卫敛汗，祛风运毒。”《衷中参西录·药物》述：“善利小便”，“善治肢体痿废。”现代药理研究报道，黄芪有明显的提高免疫功能、保护心肌、保护和改善造血系统、抗氧化、抗衰老、抗肿瘤、利尿保肾、调节血糖、调节神经系统、抗菌、抗病毒和促进消化功能等作用。
石莲子：归脾、胃、心、肺经；清湿热；开胃迸食；清心宁神；涩精止泄。
白花蛇舌草：味苦、淡，性寒。主要功效是清热解毒、消痛散结、利尿除湿。现代研究，还具有增强免疫力和抗肿瘤作用。
当归：甘、辛、温；具有抗缺氧作用；调节机体免疫功能、具有抗癌作用；护肤美容作用；补血活血作用；抑菌、抗动脉硬化作用。
紫苏子：主调中，益五脏，下气，止霍乱、呕吐、反胃，补虚劳，肥健人，利大小便，破症结，消五膈，止咳，润心肺，消痰气。
半枝莲：辛，平；有清热解毒，活血化瘀，消肿止痛，抗癌之功效。
龙葵：苦，寒。有小毒。清热，解毒，活血，消肿。
天冬：性寒，味甘，微苦。具有养阴清热，润肺滋肾的功效。用于治阴虚发热、肺痈、消渴等病症。有升高血细胞、增强网状内皮系统吞噬功能和延长抗体存在时间的作用。
麦冬：甘，微苦，微寒；归心、肺、胃经；养阴生津，润肺清心。用于肺燥干咳，阴虚痨嗽，喉痹咽痛，津伤口渴，内热消渴，心烦失眠，肠燥便秘。
五味子：功能敛肺，滋肾，生津，收汗，涩精，主治肺虚喘咳，口干作渴，自汗，盗汗，劳伤羸瘦，梦遗滑精，久泻久痢。凡一切气血耗散之休克、虚脱，皆可配补药用之。
旱莲草：味甘、酸，性凉；归肾、肝经；入阴血，善敛固；具有滋补肝肾，乌须固齿，凉血止血的功效；主治肝肾不足，眩晕耳鸣，视物昏花，腰膝酸软，发白齿摇，劳淋带浊，咯血，吐血，衄血，尿血，血痢，崩漏，外伤出血。
楮实子：性寒，味甘。功能补肾清肝、明目、利尿。用于腰膝酸软、虚劳骨蒸、砂晕目昏、目生翳膜、水肿胀满。
本发明通过中药的调理，补虚益气、健脾开胃、排毒利尿，适用于所有放疗后引起的全身反应，有助于放疗后病人体力的恢复，加快体内毒素排出，减轻肿块焮热症状，增加白细胞数量，加快身体恢复；同时具有抗肿瘤、提高免疫力的作用，更大程度的避免肿瘤复发，为病人的身体健康提供保障。
疗效判断：
显效：临床症状(虚弱、乏力、头晕、头痛、厌食、恶心、呕吐等)基本或大部分消失。
有效：临床症状明显好转。
无效：诸症无改善。
治疗结果：治疗417名放疗术后患者，使用3天本发明的中药后，显效247例，占59.2％，有效169例，占40.5％，无效1例，占0.3％。
附几例病例作进一步说明：
病例1：段某，男，54岁，因鼻咽癌进行放疗，放疗后形成口腔溃疡，一直不愈，伴有乏力、头晕、头痛、厌食症状，使用3天本发明的中药，临床症状消失，进食良好，恢复情况较好。
病例2：焦某某,女，35岁，在进行乳腺癌放疗术后，出现胸闷、轻度咳嗽，伴有心慌气短、低烧、放射部位的肿块焮热感，使用3天本发明的中药，临床症状消失，进食良好，体虚情况亦有很大改善。
具体实施方式
实施例1：
一种防治放疗后副作用的中药组合物，由以下重量份数的原料配制而成：鸡血藤4份、沙参7份、莱菔子4份、旋复花1份、黄芪4份、石莲子4份、白花蛇舌草2份、当归4份、紫苏子4份、半枝莲4份、龙葵1份、天冬5份、麦冬5份、五味子2份、旱莲草5份、楮实子4份。
制备方法是按上述重量份称取中药原料，加入冷水，没过药材4cm，浸泡1.5个小时；然后进行煎煮，先用武火煮开，煮开后转为文火熬煮30min；煮好后，滤出药汁作为头煎；将药渣重复上述步骤煎煮，煮好后，将两次煎煮的药汁合并即可。
实施例2：
一种防治放疗后副作用的中药组合物，由以下重量份数的原料配制而成：鸡血藤3份、沙参10份、莱菔子3份、旋复花2份、黄芪3份、石莲子5份、白花蛇舌草2份、当归5份、紫苏子3份、半枝莲5份、龙葵1份、天冬8份、麦冬3份、五味子3份、旱莲草3份、楮实子5份。
制备方法是按上述重量份称取中药原料，加入冷水，没过药材2cm，浸泡1个小时；然后进行煎煮，先用武火煮开，煮开后转为文火熬煮20min；煮好后，滤出药汁作为头煎；将药渣重复上述步骤煎煮，煮好后，将两次煎煮的药汁合并即可。
实施例3：
一种防治放疗后副作用的中药组合物，由以下重量份数的原料配制而成：鸡血藤5份、沙参5份、莱菔子5份、旋复花1份、黄芪5份、石莲子3份、白花蛇舌草3份、当归3份、紫苏子5份、半枝莲3份、龙葵2份、天冬3份、麦冬8份、五味子2份、旱莲草8份、楮实子3份。
制备方法是按上述重量份称取中药原料，加入冷水，没过药材5cm，浸泡2个小时；然后进行煎煮，先用武火煮开，煮开后转为文火熬煮40min；煮好后，滤出药汁作为头煎；将药渣重复上述步骤煎煮，煮好后，将两次煎煮的药汁合并即可。
以上已将本发明做一详细说明，以上所述，仅为本发明之较佳实施例而已，当不能限定本发明实施范围，即凡依本申请范围所作均等变化与修饰，皆应仍属本发明涵盖范围内。

Claims (2)

1.一种防治放疗后副作用的中药组合物，其特征在于由以下重量份数的原料配制而成：鸡血藤3～5份、沙参5～10份、莱菔子3～5份、旋复花1～2份、黄芪3～5份、石莲子3～5份、白花蛇舌草2～3份、当归3～5份、紫苏子3～5份、半枝莲3～5份、龙葵1～2份、天冬3～8份、麦冬3～8份、五味子2～3份、旱莲草3～8份、楮实子3～5份。
2.如权利要求1所述的一种防治放疗后副作用的中药组合物，其特征在于由以下重量份数的原料配制而成：鸡血藤4份、沙参7份、莱菔子4份、旋复花1份、黄芪4份、石莲子4份、白花蛇舌草2份、当归4份、紫苏子4份、半枝莲4份、龙葵1份、天冬5份、麦冬5份、五味子2份、旱莲草5份、楮实子4份。
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105477353A (zh) * 2016-03-01 2016-04-13 青岛市肿瘤医院 一种防治放疗后副作用的中药组合物
CN107303386A (zh) * 2016-04-25 2017-10-31 高安友 一种用于治疗白细胞低下的口服液的制备方法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105477353A (zh) * 2016-03-01 2016-04-13 青岛市肿瘤医院 一种防治放疗后副作用的中药组合物
CN107303386A (zh) * 2016-04-25 2017-10-31 高安友 一种用于治疗白细胞低下的口服液的制备方法

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