CN104491055A - Vein-calming particles and preparation method thereof - Google Patents

Abstract

The invention discloses vein-calming particles and a preparation method thereof. The preparation method of the vein-calming particles is characterized by comprising the following steps: taking 100g of hawthorn fruits, 100g of isatis root and 28g of gorgon fruits; crushing the materials into crude powder; putting the crude powder in a circulation ultrasonic extractor; adding water, germanium powder and Tween-60 and carrying out ultrasonic extraction; jetting, spraying and drying to prepare nano extraction powder; and adding lactose and dextrin to prepare the vein-calming particles. When the vein-calming particles are used for treating hyperlipoproteinemia, the treatment effect is remarkably superior to those of commercially-available vein-calming particles; a good effect is achieved.

Description

A kind of MAIAN KELI and preparation method thereof

Technical field

The present invention relates to the field of Chinese medicines, be specifically related to a kind of MAIAN KELI and preparation method thereof.

Background technology

MAIAN KELI treatment hyperlipoproteinemia, for reducing serum cholesterol, atherosclerosis, to reduction triglyceride, beta lipoprotein also has certain effect.Commercially available MAIAN KELI is due to prescription and technological reason, and curative effect is not satisfactory, and preparation adopts traditional handicraft preparation, there is the shortcoming that curative effect is low.

Summary of the invention

The present invention, for overcoming above-mentioned deficiency, provides MAIAN KELI that a kind of curative effect is high and preparation method thereof.

Invention embodiment is as follows:

Get Fructus Crataegi 100g, Radix Isatidis 100g, Semen Euryales 28g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 6980g water, 2 ~ 4g germanium powder, 2 ~ 4g polysorbate60, select supersonic frequency 50 ~ 60KHz, pressure 0.3 ~ 0.5 Mpa extracts 30 minutes, uses 80 mesh screen, obtains extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 40 ~ 50 DEG C, pressure 0.02 ~ 0.04 Mpa, 400 ~ 600 meters per second of flow velocity, obtains nanometer extract powder; Get extract powder and add lactose 400g, dextrin 100g, use water wet granulation, 60 DEG C of dryings, granulate, adds Pulvis Talci 10g, mixing, obtained MAIAN KELI.

The raw material standards that above-mentioned embodiment is mentioned is as follows:

Fructus Crataegi: China's coastal port one ministerial standard.This product is the dry mature fruit of rosaceous plant Fructus Pyri Pashiae Crataegus Pinnatifida Bge. var.major. N.E.Br. or crataegus pin natifida var. Major Crataegus pinnatifida Bge..Gather during fruit maturation in autumn.Section, dry.

Radix Isatidis: China's coastal port one ministerial standard.This product is the dry root of cruciferae isatis Isatis indigotica Fort..Autumn digs, and removing silt, dries.

Semen Euryales: China's coastal port one ministerial standard.This product is the dry mature kernal of nymphaeaceae plant Gorgon euryale Euryale ferox Salisb..Time of the year when autumn changes into winter gathers mature fruit, and removing peel, takes out seed, cleans, then removes duricrust (episperm), dry.

Germanium powder: germanium dioxide: No. CAS: 1310-53-8: industry standard: lark prestige Science and Technology Ltd.;

Polysorbate60: Chinese Pharmacopoeia version two ministerial standard in 2010;

Lactose: Chinese Pharmacopoeia version two ministerial standard in 2010;

Dextrin: Chinese Pharmacopoeia version two ministerial standard in 2010;

Pulvis Talci: Chinese Pharmacopoeia version one ministerial standard in 2010;

Raw material used by above MAIAN KELI all can be bought from pharmaceuticals and obtain, and is not limited to typical production producer, all can be used to implement the present invention program as long as meet quality standard.

The key equipment that foregoing invention embodiment is mentioned is as follows:

Circulating ultrasonic machine: supersonic frequency 20 ~ 100KHz,

(typical production producer: Beijing Hongxianglong Biotechnology Development Co., Ltd)

Jet spray dryer: inlet temperature scope 30 ~ 70 DEG C, 300 ~ 900 meters per second of effluxvelocity scope;

(typical production producer: Nai Nuo bio tech ltd, Beijing)

Raw material used by above MAIAN KELI all can be bought from pharmaceuticals and obtain, and all can be used to implement the present invention program as long as meet national standard.

In foregoing invention scheme, term used is pharmacy proprietary term, as " decompression " etc. all defers to Chinese Pharmacopoeia regulation and pharmaceutical practice of being correlated with.

Unit g in the present invention also can be other weight portion, does not affect the enforcement of the present invention program.

Equipment Market described in the present invention program all has sale, is not limited to typical production producer, as long as technical specification can reach requirement, all can be used to realize the present invention.

Detailed description of the invention

Specific embodiments of the invention 1

Get Fructus Crataegi 100g, Radix Isatidis 100g, Semen Euryales 28g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 6980g water, 2g germanium powder, 2g polysorbate60, select supersonic frequency 50KHz, pressure 0.3Mpa extracts 30 minutes, uses 80 mesh screen, obtains extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 40 DEG C, pressure 0.02Mpa, 400 meters per second of flow velocity, obtains nanometer extract powder; Get extract powder and add lactose 400g, dextrin 100g, use water wet granulation, 60 DEG C of dryings, granulate, adds Pulvis Talci 10g, mixing, obtained MAIAN KELI.

Specific embodiments of the invention 2

Get Fructus Crataegi 100g, Radix Isatidis 100g, Semen Euryales 28g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 6980g water, 4g germanium powder, 4g polysorbate60, select supersonic frequency 60KHz, pressure 0.5 Mpa extracts 30 minutes, uses 80 mesh screen, obtains extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 50 DEG C, pressure 0.04 Mpa, 600 meters per second of flow velocity, obtains nanometer extract powder; Get extract powder and add lactose 400g, dextrin 100g, use water wet granulation, 60 DEG C of dryings, granulate, adds Pulvis Talci 10g, mixing, obtained MAIAN KELI.

Specific embodiments of the invention 3

Get Fructus Crataegi 100g, Radix Isatidis 100g, Semen Euryales 28g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 6980g water, 3g germanium powder, 3g polysorbate60, select supersonic frequency 55KHz, pressure 0.4Mpa extracts 30 minutes, uses 80 mesh screen, obtains extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 45 DEG C, pressure 0.03Mpa, 500 meters per second of flow velocity, obtains nanometer extract powder; Get extract powder and add lactose 400g, dextrin 100g, use water wet granulation, 60 DEG C of dryings, granulate, adds Pulvis Talci 10g, mixing, obtained MAIAN KELI.

Above embodiment illustrates, adopts the extreme condition of embodiment of the present invention and optimal conditions all can make MAIAN KELI.Actual effect of the present invention is investigated below with the MAIAN KELI that embodiment 3 is obtained:

(1) embodiment 3 MAIAN KELI and commercially available MAIAN KELI treat hyperlipoproteinemia Disease Clinical observation of curative effect

1 case scenario

Statistics outpatient service and inpatient, observe hyperlipoproteinemia case 109 example, 48 years old mean age altogether.Patient is divided into two groups, test group takes embodiment 3 MAIAN KELI, and matched group takes traditional MAIAN KELI.

2 efficacy assessment standards

According to new Chinese medicine guideline of clinical investigations tcm syndrome curative effect determinate standard:

Cure: tcm clinical practice symptom, sign disappear or substantially disappear, syndrome integral reduces >=95%.

Effective: tcm clinical practice symptom, sign are obviously improved, syndrome integral reduces >=70%.

Effective: tcm clinical practice symptom, sign all take a favorable turn, syndrome integral reduces >=30%.

Invalid: tcm clinical practice symptom, sign are all not improved or increase the weight of, syndrome integral reduces < 30%.

Computing formula: [before (before treatment the rear integration of integration-treatment) ÷ treatment integration] × 100%.

3 clinical observation result

Table 1 embodiment 3 MAIAN KELI and the contrast of commercially available MAIAN KELI clinical efficacy

Above-mentioned clinical observation on the therapeutic effect result shows, MAIAN KELI prepared by the present invention is when treating hyperlipoproteinemia, evident in efficacy higher than commercially available MAIAN KELI, p < 0.05.

Claims (3)

1. treat a Chinese medicine for hyperlipoproteinemia, it is characterized in that getting Fructus Crataegi 100g, Radix Isatidis 100g, Semen Euryales 28g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 6980g water, 2 ~ 4g germanium powder, 2 ~ 4g polysorbate60, select supersonic frequency 50 ~ 60KHz, pressure 0.3 ~ 0.5 Mpa extracts 30 minutes, use 80 mesh screen, obtain extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 40 ~ 50 DEG C, pressure 0.02 ~ 0.04 Mpa, 400 ~ 600 meters per second of flow velocity, obtains nanometer extract powder; Get extract powder and add lactose 400g, dextrin 100g, use water wet granulation, 60 DEG C of dryings, granulate, adds Pulvis Talci 10g, mixing, obtained MAIAN KELI.

2. the preparation method of Chinese medicine according to claim 1, is characterized in that getting Fructus Crataegi 100g, Radix Isatidis 100g, Semen Euryales 28g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 6980g water, 2 ~ 4g germanium powder, 2 ~ 4g polysorbate60, select supersonic frequency 50 ~ 60KHz, pressure 0.3 ~ 0.5 Mpa extracts 30 minutes, use 80 mesh screen, obtain extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 40 ~ 50 DEG C, pressure 0.02 ~ 0.04 Mpa, 400 ~ 600 meters per second of flow velocity, obtains nanometer extract powder; Get extract powder and add lactose 400g, dextrin 100g, use water wet granulation, 60 DEG C of dryings, granulate, adds Pulvis Talci 10g, mixing, obtained MAIAN KELI.

3. the preparation method of Chinese medicine according to claim 1, is characterized in that getting Fructus Crataegi 100g, Radix Isatidis 100g, Semen Euryales 28g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 6980g water, 3g germanium powder, 3g polysorbate60, select supersonic frequency 55KHz, pressure 0.4Mpa extracts 30 minutes, use 80 mesh screen, obtain extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 45 DEG C, pressure 0.03Mpa, 500 meters per second of flow velocity, obtains nanometer extract powder; Get extract powder and add lactose 400g, dextrin 100g, use water wet granulation, 60 DEG C of dryings, granulate, adds Pulvis Talci 10g, mixing, obtained MAIAN KELI.