CN104490971A - Medicine for treating trachitis and bronchitis and preparation method thereof - Google Patents
Medicine for treating trachitis and bronchitis and preparation method thereof Download PDFInfo
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- CN104490971A CN104490971A CN201410824458.9A CN201410824458A CN104490971A CN 104490971 A CN104490971 A CN 104490971A CN 201410824458 A CN201410824458 A CN 201410824458A CN 104490971 A CN104490971 A CN 104490971A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention discloses a medicine for treating trachitis and bronchitis and a preparation method thereof. The medicine is prepared from the following raw materials in parts by weight: 15-90 parts of fewflower lysionotus herb, 10-80 parts of aster and 5-40 parts of flos farfarae. The preparation method comprises the following steps: sampling the various raw materials in parts by weight, respectively adding water for decocting for three times, mixing the decoction, standing, concentrating the supernatant, cooling, adding dextrin and sugar, uniformly mixing, granulating, drying and performing split charging. The medicine provided by the invention has the characteristics of obvious curative effect, stable effect, safety, no toxicity, zero side effect and low price. According to clinical application of 60 cases, the total effective rate is 98.3 percent, and the administration is convenient and rapid.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of medicine for the treatment of tracheobronchitis, also relate to the preparation method of this medicine simultaneously.
Background technology
Tracheitis is due to the trachea-bronchial epithelial cell mucosal inflammatory change infected or non-infective agent causes, mucous secretion increases, for want of anion and the activity of tunica mucosa tracheae epithelium fine hair internal respiration enzyme is reduced, affects the secretory function of alveolar and the ventilation of lung and ventilatory.Clinically with chronic cough, to cough up phlegm or with panting for principal character.Primary disease early symptom is comparatively light, how to show effect in the winter time, alleviate, and the course of disease is slow after the spring is warm, therefore not for people note.Primary disease is one of China's common frdquently encountered disease, and age of onset is many more than 40 years old, and smoking patients is apparently higher than non-smoking patient, and in China's prevalence north higher than south, rural area comparatively city sickness rate is slightly high.
Bronchitis refers to the chronic nonspecific inflammation of trachea-bronchial epithelial cell mucosa and surrounding tissue thereof.Bronchitis main cause is that the repeated infection of virus and antibacterial defines bronchial chronic nonspecific inflammation.Under mercury dropped, respiratory tract small blood vessel spasm ischemia, defense function, degradation is beneficial to pathogenic; The chronic stimulations such as smog dust, atmosphere pollution also can be fallen ill; Smoking makes that bronchospasm, mucosa make a variation, ciliary movement reduces, mucilage secretion increases and is easy to ill; Intolerance factors also has certain relation.
Cough, expectoration are the modal clinical manifestations of respiratory system disease such as trachea-bronchial epithelial cell, and diseases of respiratory system is called that lung system is sick by Chinese medicine.Forgive Chinese medical disease and mainly contain flu, cough, lung-heat, the syndrome of dyspnea, bronchial wheezing, pulmonary distension, lung abscess, pulmonary tuberculosis, hydrothorax, pulmonary carcinoma, pneumoconiosis etc.All different sick kinds or the different syndrome of the traditional Chinese medical science, its total symptom must have performance namely to cough, cough up phlegm.Get to the bottom of sb.'s illness, Chinese medicine thinks that cough attacks lung system, or visceral dysfunction by six climate exopathogens exopathogen, and inside injure lung, lung qi is unclear, lose in a surname respectful become.If respiratory system disease is treated not in time, human body Health and Living quality will be had a strong impact on.
For tracheobronchitis, the therapeutic effect such as chemicals example hydrochloric acid ephedrine, codeine phosphate, morphine hydrochloride are pretty good, preventing phlegm from forming and stopping coughing medicine also conventional clinically, but all have additive, and toxic and side effects is large and on the high side.Existing compound Chinese medicinal preparation, mostly is the large prescription drug of more than 10 tastes, and due to complicated component, cause difficult quality to control, therapeutic effect is not good.
Summary of the invention
The object of the present invention is to provide a kind of evident in efficacy, effect stability, safe without toxic side effect and the medicine of cheap treatment tracheobronchitis.
Another object of the present invention is to the preparation method of the medicine that this treatment tracheobronchitis is provided.
A kind of medicine for the treatment of tracheobronchitis of the present invention, by weight, comprises following raw material:
Herba Lysionoti Pauciflori 15-90 part, Radix Asteris 10-80 part, Flos Farfarae 5-40 part.
A kind of medicine for the treatment of tracheobronchitis of the present invention, is characterized in that: by weight, also comprises following raw material:
Dextrin 3.6-20 part, sugared 17.4-98 part.
One of the present invention treats tracheobronchial medicine, by weight, comprises following raw material:
Herba Lysionoti Pauciflori 15 parts, Radix Asteris 10 parts, Flos Farfarae 5 parts, 3.6 parts, dextrin, sugar 17.4 parts.
A kind of preparation method for the treatment of the medicine of tracheobronchitis of the present invention, comprises the following steps:
(1) screen raw material, take Herba Lysionoti Pauciflori, Radix Asteris and Flos Farfarae by weight, cleaning;
(2) add Herba Lysionoti Pauciflori, Radix Asteris and Flos Farfarae total amount 10.34 times of water gagings, 8 times of water gagings, 8 times amount soak by water three times respectively, each 1 hour, collecting decoction, left standstill 20h;
(3) get that supernatant concentration to temperature is 80 DEG C, relative density is the extractum of 1.20-1.30, let cool room temperature, add dextrin and sugar, mix homogeneously, granulate, dry, subpackage or make other any dosage form and get final product.
A kind of preparation method for the treatment of the medicine of tracheobronchitis of the present invention, comprises the following steps:
(1) screen raw material, take Herba Lysionoti Pauciflori, Radix Asteris and Flos Farfarae by weight, cleaning;
(2) add the 4-6 times amount soak by water of Herba Lysionoti Pauciflori, Radix Asteris and Flos Farfarae gross weight, be fried open 30 minutes, elimination medicinal residues, precipitate after 1 hour, filter and get final product.
The present invention compared with prior art, has obvious beneficial effect, as can be known from the above technical solutions: the present invention only selects Herba Lysionoti Pauciflori, Radix Asteris and Flos Farfarae three taste crude drug, utilizes the comprehensive coordination effect of each component can treat tracheobronchitis disease.For wind-dryness impairing the lung card of coughing in TCM syndrome, the few expectorant of symptoms including cough, cough up phlegm not well, nasopharynx is dry, red tip of the tongue, yellow and thin fur, floating-rolling pulse; Acute and chronic tracheobronchitis is shown in above-mentioned patient.Because adopting natural plants to be raw material, the present invention has no side effect to human-body safety, free from extraneous odour, and cheap.Show through clinical observation, to improving the clinical disease of tracheitis and bronchitis, therapeutic effect is remarkable, also have simultaneously reduce phlegm, the effect of cough-relieving, without additive.
Detailed description of the invention
The beneficial effect of medicine of the present invention is set forth further below by way of test example.
test example:the clinical observation of medicine of the present invention
Clinical data:
All cases 60 example, male 40 example, women 20 example.Wherein, age 30-40 year patient 11 example, age 41-50 year patient 13 example, age 51-60 year patient 25 example, age 61-70 year patient 11 example.
Diagnostic criteria:
" Western medicine diagnose standard "
Using method:
Oral medicine gained granule of the present invention, each 5g, every day 3 times 6 days is a course for the treatment of, altogether 1-2 the course for the treatment of.
Criterion of therapeutical effect:
Clinical cure: symptom is all eliminated;
Effective: cardinal symptom is eliminated;
Effective: cardinal symptom is eliminated substantially;
Invalid: compare with before treatment, each side is unchanged or add severe one.
Therapeutic effect:
60 routine tracheobronchitis patients use medicine of the present invention, clinical cure 40 example, effective 16 examples, effective 3 examples, and invalid 1 example, clinical cure rate 66.7%, total obvious effective rate 93.3%, total effective rate 98.3%, all cases all have no adverse reaction.
To clinical cure personnel random inspection 5 people, follow up a case by regular visits to and have no recurrence in 1 year.
embodiment 1
Treat a medicine for tracheobronchitis, comprise the following steps:
(1) screen raw material, take Herba Lysionoti Pauciflori 90kg, Radix Asteris 10kg, Flos Farfarae 40kg, cleaning;
(2) add 1447.6kg water, 1120kg water, 1120kg soak by water three times respectively, each 1 hour, collecting decoction, leave standstill 20h;
(3) get that supernatant concentration to temperature is 80 DEG C, relative density is 1.30 extractum, let cool, add dextrin 20kg, sugared 98kg, mix homogeneously, granulate, dry, subpackage and get final product.
embodiment 2
Treat a medicine for tracheobronchitis, comprise the following steps:
(1) screen raw material, take Herba Lysionoti Pauciflori 15kg, Radix Asteris 80kg, Flos Farfarae 5kg, cleaning;
(2) add 1034kg water, 800kg water, 800kg soak by water three times respectively, each 1 hour, collecting decoction, leave standstill 20h;
(3) get that supernatant concentration to temperature is 80 DEG C, relative density is 1.20 extractum, let cool, add dextrin 11.8kg, sugared 57.7kg, mix homogeneously, granulate, dry, subpackage and get final product.
embodiment 3
Treat a medicine for tracheobronchitis, comprise the following steps:
(1) screen raw material, take Herba Lysionoti Pauciflori 15kg, Radix Asteris 10kg, Flos Farfarae 5kg, cleaning;
(2) add 310.2kg water, 240kg water, 240kg soak by water three times respectively, each 1 hour, collecting decoction, leave standstill 20h;
(3) get that supernatant concentration to temperature is 80 DEG C, relative density is 1.25 extractum, let cool, add dextrin 3.6kg, sugared 17.4kg, mix homogeneously, granulate, dry, subpackage and get final product.
embodiment 4
Treat a medicine for tracheobronchitis, comprise the following steps:
(1) screen raw material, take Herba Lysionoti Pauciflori 52g, Radix Asteris 45g, Flos Farfarae 22g, cleaning;
(2) add 595g soak by water, be fried open 30 minutes, elimination medicinal residues, precipitate after 1 hour, filter and get final product.
embodiment 5
Treat a medicine for tracheobronchitis, comprise the following steps:
(1) screen raw material, take Herba Lysionoti Pauciflori 85g, Radix Asteris 70g, Flos Farfarae 35g, cleaning;
(2) add 1140g soak by water, be fried open 30 minutes, elimination medicinal residues, precipitate after 1 hour, filter and get final product.
embodiment 6
Treat a medicine for tracheobronchitis, comprise the following steps:
(1) screen raw material, take Herba Lysionoti Pauciflori 40g, Radix Asteris 60g, Flos Farfarae 30g, cleaning;
(2) add 520g soak by water, be fried open 30 minutes, elimination medicinal residues, precipitate after 1 hour, filter and get final product.
The above, it is only preferred embodiment of the present invention, not any pro forma restriction is done to the present invention, anyly do not depart from technical solution of the present invention content, the any simple modification done above embodiment according to technical spirit of the present invention, equivalent variations and modification, all still belong in the scope of technical solution of the present invention.
Claims (5)
1. treat a medicine for tracheobronchitis, by weight, comprise following raw material: Herba Lysionoti Pauciflori 15-90 part, Radix Asteris 10-80 part, Flos Farfarae 5-40 part.
2. a kind of medicine for the treatment of tracheobronchitis as claimed in claim 1, is characterized in that: by weight, also comprises following raw material: dextrin 3.6-20 part, sugared 17.4-98 part.
3. one as claimed in claim 2 treats tracheobronchial medicine, it is characterized in that: by weight, comprises following raw material: Herba Lysionoti Pauciflori 15 parts, Radix Asteris 10 parts, Flos Farfarae 5 parts, 3.6 parts, dextrin, sugar 17.4 parts.
4. a kind of preparation method for the treatment of the medicine of tracheobronchitis as described in one of claim 1 or 2 or 3, comprises the following steps:
(1) screen raw material, take Herba Lysionoti Pauciflori, Radix Asteris and Flos Farfarae by weight, cleaning;
(2) add Herba Lysionoti Pauciflori, Radix Asteris and Flos Farfarae total amount 10.34 times of water gagings, 8 times of water gagings, 8 times amount soak by water three times respectively, each 1 hour, collecting decoction, left standstill 20h;
(3) get that supernatant concentration to temperature is 80 DEG C, relative density is the extractum of 1.20-1.30, cool to room temperature, adds dextrin and sugar, mix homogeneously, granulate, dry, subpackage or make other any dosage form and get final product.
5. a kind of preparation method for the treatment of the medicine of tracheobronchitis as described in one of claim 1 or 2 or 3, comprises the following steps:
(1) screen raw material, take Herba Lysionoti Pauciflori, Radix Asteris and Flos Farfarae by weight, cleaning;
(2) add the 4-6 times amount soak by water of Herba Lysionoti Pauciflori, Radix Asteris and Flos Farfarae medical material gross weight, be fried open 30 minutes, elimination medicinal residues, precipitate after 1 hour, filter and get final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410824458.9A CN104490971A (en) | 2014-12-26 | 2014-12-26 | Medicine for treating trachitis and bronchitis and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410824458.9A CN104490971A (en) | 2014-12-26 | 2014-12-26 | Medicine for treating trachitis and bronchitis and preparation method thereof |
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| CN104490971A true CN104490971A (en) | 2015-04-08 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201410824458.9A Pending CN104490971A (en) | 2014-12-26 | 2014-12-26 | Medicine for treating trachitis and bronchitis and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105250645A (en) * | 2015-11-18 | 2016-01-20 | 吴斌 | Traditional Chinese medicine for treating chronic bronchitis |
| CN105343214A (en) * | 2015-12-09 | 2016-02-24 | 济南思拓新源医药科技有限公司 | Medicine used for treating chronic bronchitis caused by phlegm-heat accumulated in lung |
Citations (3)
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| CN102688355A (en) * | 2012-06-14 | 2012-09-26 | 李良 | Traditional Chinese medicine decoction of common coltsfoot flower for treating asthma and preparation method thereof |
| CN104161970A (en) * | 2013-05-16 | 2014-11-26 | 李立辉 | Traditional Chinese medicine for treating children's chronic bronchitis |
| CN104258333A (en) * | 2014-09-25 | 2015-01-07 | 苏州市天灵中药饮片有限公司 | Cough relieving spray and preparation method thereof |
-
2014
- 2014-12-26 CN CN201410824458.9A patent/CN104490971A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102688355A (en) * | 2012-06-14 | 2012-09-26 | 李良 | Traditional Chinese medicine decoction of common coltsfoot flower for treating asthma and preparation method thereof |
| CN104161970A (en) * | 2013-05-16 | 2014-11-26 | 李立辉 | Traditional Chinese medicine for treating children's chronic bronchitis |
| CN104258333A (en) * | 2014-09-25 | 2015-01-07 | 苏州市天灵中药饮片有限公司 | Cough relieving spray and preparation method thereof |
Non-Patent Citations (4)
| Title |
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| 徐因: "慢性支气管炎的中医治疗体会", 《河北中医》 * |
| 耿呈祥: "《耿呈祥老中医经验方实录》", 31 January 2013, 山西科学技术出版社 * |
| 陈家鼎: "自拟冬菀汤治疗急性气管-支气管炎50例", 《河北中医》 * |
| 黄权祥: "自拟化痰燥湿汤治疗慢性支气管炎疗效观察", 《辽宁中医药大学学报》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105250645A (en) * | 2015-11-18 | 2016-01-20 | 吴斌 | Traditional Chinese medicine for treating chronic bronchitis |
| CN105343214A (en) * | 2015-12-09 | 2016-02-24 | 济南思拓新源医药科技有限公司 | Medicine used for treating chronic bronchitis caused by phlegm-heat accumulated in lung |
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Application publication date: 20150408 |
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