CN104488956A - Pharmaceutical composition for preventing and treating radopholus similis - Google Patents
Pharmaceutical composition for preventing and treating radopholus similis Download PDFInfo
- Publication number
- CN104488956A CN104488956A CN201410701244.2A CN201410701244A CN104488956A CN 104488956 A CN104488956 A CN 104488956A CN 201410701244 A CN201410701244 A CN 201410701244A CN 104488956 A CN104488956 A CN 104488956A
- Authority
- CN
- China
- Prior art keywords
- lythidathion
- avermectin
- pharmaceutical composition
- similes thorne
- radopholus similes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention belongs to the technical field of pesticides and particularly discloses a pharmaceutical composition for preventing and treating radopholus similis. The pharmaceutical composition comprises abamectin and lythidathion, wherein the mixing volume rate of crude abamectin to crude lythidathion is 4:7, 5:3 or 4:1. After being mixed at a specific ratio, the two drugs including abamectin and lythidathion can play a synergistic effect on the toxicity of radopholus similis, so that the effect on efficiently preventing and treating the radopholus similis is achieved. In addition, the two drugs are matched to be used, so that the use concentrations of the drugs can be reduced, furthermore, the cost can be reduced, and most importantly, the hazards to plants can be reduced.
Description
Technical field
The present invention relates to technical field of pesticide, specifically disclose a kind of pharmaceutical composition preventing and treating radopholus similes thorne.
Background technology
Radopholus similes thorne (
radopholus similis) have another name called banana root rot, be the most dangerous obligatory parasitism nematode of banana, flower planting industry and a lot of economic crops, widely, the host plant reported has kind more than 350 to host range.This nematode, except serious harm banana, pepper and coconut, also endangers the ornamental plants such as the economic crops such as soybean, corn, jowar, sugarcane, eggplant, coffee, tomato and potato and the red palm, arrowroot, palm.The under ground portion of the host plants such as banana, pepper, coconut, betel nut, avocado, Xiao's Maranta and the soil sticked are the main paties of radopholus similes thorne long-distance communications.Because this eelworm harm is serious, therefore, have 55 countries to implement offical control to it, this nematode is also classified as the dangerous pest of the class plant quarantine forbidding entering a country by China.
The control of radopholus similes thorne comprises cultural control, biological control, physical control, chemical control etc., but chemical control is the important means of this nematode of control always.Because vegetables are to the particular/special requirement of chemical control, the chemical agent being applicable to radopholus similes thorne control is little, only have in non-stifling property nematode killing agent the low-residual such as Avermectin, lythidathion medicament several.But how also rarely known by the people these two kinds of medicaments are to the complex role of radopholus similes thorne.
Summary of the invention
The present invention, in order to overcome in prior art the defect of the medicine lacking effectively control Meloidogyne incognita, provides a kind of pharmaceutical composition of high-efficiency prevention and control Meloidogyne incognita.
To achieve these goals, the present invention is achieved by the following technical programs:
Prevent and treat a pharmaceutical composition for radopholus similes thorne, comprise Avermectin and lythidathion, the mixture volume ratio of described Avermectin and the former medicine of lythidathion is 4:7,5:3,4:1.
The present invention found through experiments, Avermectin and lythidathion have radopholus similes thorne separately certain murders effect, if but both are mixed according to specific ratio, the effect of Synergistic can be had, if but mix not in accordance with this special ratios, the effect of superposition can only be had effect.
Preferably, the mixture volume ratio of described Avermectin and the former medicine of lythidathion is 4:1.The present invention studies discovery, and when the mixture volume ratio of Avermectin and lythidathion is 4:1, both Synergistic results are the most remarkable.
Preferably, the weight percentage of described active ingredient is 5 ~ 50%.
More preferably, the weight percentage of described active ingredient is 5 ~ 30%.
Preferably, described combination dosage form comprises missible oil, microemulsion, aqueous emulsion, suspending agent, wetting powder and water dispersible granules.
Compared with prior art, the present invention has following beneficial effect:
Avermectin and lythidathion two kinds of medicines, by the mixing of special ratios, the virulence effect to radopholus similes thorne can be played the effect of Synergistic by the present invention, and from realizing the effect of high-efficiency prevention and control radopholus similes thorne.And, by two kinds of medicines with the use of, the working concentration of medicine can be reduced, not only can reduce costs, the more important thing is the harm that can reduce plant.
Embodiment
Further describe invention thinking of the present invention below in conjunction with specific embodiment, but embodiment does not limit in any form to protection scope of the present invention.Unless stated otherwise, the reagent adopted in embodiment, method and apparatus are the art conventional reagent, method and apparatus.
Unless stated otherwise, the feeds utilized raw material of following examples, reagent and material are commercial.
Radopholus similes thorne used in embodiment is from the seizure of rotten of banana, by for subsequent use after the carrot medium of the radopholus similes thorne of seizure in greenhouse breeds sufficient amount.The rearing conditions of radopholus similes thorne is: temperature 25-30 DEG C, relative moisture 40% ~ 70%, and suitable soil acidity-basicity ph 4 ~ 8 does not contact any chemical agent between feeding period.
Described Avermectin and lythidathion are common commercially available prod, and the concentration of Avermectin is 92.8%, during the concentration of lythidathion 80.3%.Former medicine.
embodiment 1
Prevent and treat a pharmaceutical composition for radopholus similes thorne, be made up of Avermectin and lythidathion, the mixture volume ratio of described Avermectin and lythidathion is 1:15; The concentration of Avermectin is 92.8%, 80.3% former medicine during the concentration of lythidathion.
embodiment 2
Prevent and treat a pharmaceutical composition for radopholus similes thorne, be made up of Avermectin and lythidathion, the mixture volume ratio of described Avermectin and lythidathion is 1:4; The concentration of Avermectin is 92.8%, 80.3% former medicine during the concentration of lythidathion.
embodiment 3
Prevent and treat a pharmaceutical composition for radopholus similes thorne, be made up of Avermectin and lythidathion, the mixture volume ratio of described Avermectin and lythidathion is 4:7; The concentration of Avermectin is 92.8%, 80.3% former medicine during the concentration of lythidathion.
embodiment 4
Prevent and treat a pharmaceutical composition for radopholus similes thorne, be made up of Avermectin and lythidathion, the mixture volume ratio of described Avermectin and lythidathion is 5:3; The concentration of Avermectin is 92.8%, 80.3% former medicine during the concentration of lythidathion.
embodiment 5
Prevent and treat a pharmaceutical composition for radopholus similes thorne, be made up of Avermectin and lythidathion, the mixture volume ratio of described Avermectin and lythidathion is 4:1; The concentration of Avermectin is 92.8%, 80.3% former medicine during the concentration of lythidathion.
embodiment 6
Be used for the pharmaceutical composition of the formula of different proportion shown in embodiment 1-5 killing the test of radopholus similes thorne second instar larvae, experiment number of repetition twice, each concentration in triplicate, each repetition 30.
Drug use method:
Single dose: the mother liquor former medicine being configured to 10000ppm, dilutes it afterwards, and the concentration of Avermectin is chosen as 500mg/L, 250mg/L, 125 mg/L, 62.5 mg/L and 15.625 mg/L; The concentration of fosthiazate is 200 mg/L, 100 mg/L, 50 mg/L, 25 mg/L and 12.5 mg/L.
Mixture: the Avermectin of selection: the proportioning of fosthiazate is 1:15,1:4,4:7,5:3,4:1.Examination concentration gradient is supplied to be 16 mg/L, 8 mg/L, 4 mg/L, 2 mg/L, 1 mg/L.
The nematode liquid of the liquid and 0.25ml of getting 0.25ml mixes in the raw drafting board be put into containing 24 holes, and each drug concentration process repeats 3 times.Respectively with 2. 5% xylene solution and 2.5% acetone soln in contrast.
Data survey and statistical analysis: each test is all measure in medication and after processing 12 hours.Adopt needle point method, after medication process, use the individuality that dissecting needle acupuncture figure is stiff under the microscope, see that whether real it is dead, calculate dead borer population and supply the total borer population of examination.
Synergy calculates: calculate built agent according to LD50 and must survey toxicity index (ATI), theoretical toxicity index (TTI) and co-toxicity coefficient (CTC).If binary built agent is M, the single dose of composition M is A and B, and toxicity index is K, and percentage composition is P, take A as standard single dose.
Computing formula is as follows:
Toxicity index (TIA)=× 100=100 of A medicament
The toxicity index (TIB)=× 100 of B medicament
The actual toxicity index (ATI)=× 100 of M medicament
Theoretical toxicity index (TTI)=TIA × PA+TIB × PB of M medicament
Co-toxicity coefficient=× 100 of M medicament
Avermectin and the Toxicity Determination of lythidathion to radopholus similes thorne the results are shown in Table 1, as can be seen from Table 1, after 12h effect, the lethal effect of Avermectin to nematode is better than fosthiazate, wherein the LD50 of Avermectin is 1.28ug/ml, and the LD50 of lythidathion is 7.17ug/ml.In Avermectin and lythidathion 5 kinds are composite, 3 kinds have certain synergistic effect, wherein best with the ratio synergistic effect of 4:1.Avermectin and the control of lythidathion to radopholus similes thorne have good effect, especially their the composite control efficiency that can better play radopholus similes thorne, co-toxicity coefficient can reach 144.67, apparently higher than each single dose, and has good synergistic effect.
Claims (5)
1. prevent and treat a pharmaceutical composition for radopholus similes thorne, it is characterized in that, comprise Avermectin and lythidathion, the mixture volume ratio of described Avermectin and the former medicine of lythidathion is 4:7,5:3,4:1.
2. the pharmaceutical composition of control radopholus similes thorne according to claim 1, is characterized in that, the mixture volume ratio of described Avermectin and the former medicine of lythidathion is 4:1.
3. the pharmaceutical composition of control radopholus similes thorne according to claim 1 and 2, is characterized in that, the weight percentage of described active ingredient is 5 ~ 50%.
4. composition according to claim 3, is characterized in that, the weight percentage of described active ingredient is 5 ~ 30%.
5. composition according to claim 1 and 2, is characterized in that, described combination dosage form comprises missible oil, microemulsion, aqueous emulsion, suspending agent, wetting powder and water dispersible granules.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410701244.2A CN104488956A (en) | 2014-11-28 | 2014-11-28 | Pharmaceutical composition for preventing and treating radopholus similis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410701244.2A CN104488956A (en) | 2014-11-28 | 2014-11-28 | Pharmaceutical composition for preventing and treating radopholus similis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104488956A true CN104488956A (en) | 2015-04-08 |
Family
ID=52930489
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410701244.2A Pending CN104488956A (en) | 2014-11-28 | 2014-11-28 | Pharmaceutical composition for preventing and treating radopholus similis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104488956A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106332910A (en) * | 2016-08-23 | 2017-01-18 | 广西易多收生物科技有限公司 | Pharmaceutical composition for killing burrowing nematode of banana trees and preparation method thereof |
| CN107347908A (en) * | 2017-08-21 | 2017-11-17 | 山东华阳农药化工集团有限公司 | A kind of compound Avermectins compound finish of ultra-low volume fosthiazate and preparation method |
| CN108782608A (en) * | 2018-07-20 | 2018-11-13 | 海南省农业科学院植物保护研究所 | A kind of composition pesticide for preventing root-knot nematode |
-
2014
- 2014-11-28 CN CN201410701244.2A patent/CN104488956A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106332910A (en) * | 2016-08-23 | 2017-01-18 | 广西易多收生物科技有限公司 | Pharmaceutical composition for killing burrowing nematode of banana trees and preparation method thereof |
| CN107347908A (en) * | 2017-08-21 | 2017-11-17 | 山东华阳农药化工集团有限公司 | A kind of compound Avermectins compound finish of ultra-low volume fosthiazate and preparation method |
| CN108782608A (en) * | 2018-07-20 | 2018-11-13 | 海南省农业科学院植物保护研究所 | A kind of composition pesticide for preventing root-knot nematode |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103563901B (en) | A kind of Efficient insecticidal composition containing propylene glycol alginate | |
| CN104115845B (en) | A kind of high-efficient pesticide composition containing fluorobenzene insect amide | |
| CN108651463A (en) | A kind of efficient bactericidal composite containing kasugarnycin | |
| CN102028001B (en) | Sophora alopecuroides L alkaloid-containing plant-derived synergistic compound aphicide and preparation method thereof | |
| CN103598210A (en) | Pesticide composition for preventing and controlling nematode | |
| CN104488956A (en) | Pharmaceutical composition for preventing and treating radopholus similis | |
| CN105104391A (en) | Bactericidal composition containing berberine and oxine-copper | |
| CN103563899B (en) | High-efficient pesticide composition | |
| CN101803605B (en) | Insecticidal composition of butene-fipronil and spinosad | |
| CN103563962B (en) | A kind of Pesticidal combination containing propylene glycol alginate and anabasine | |
| CN107006496A (en) | A kind of bactericidal composition containing kasugarnycin and jamaicin | |
| CN104488951A (en) | Pharmaceutical composition for preventing and treating meloidogyne javanica | |
| CN103181392A (en) | Mixture preparation of nitenpyram and abamectin and preparation method | |
| CN103478133A (en) | Sterilization composition containing fluopicolide and methoxy acrylate | |
| CN102308837A (en) | Insecticidal composition | |
| CN105794859B (en) | A kind of Pesticidal combination containing Conidiobolus thromboides and biogenic substances | |
| CN105340951A (en) | Medicine composition for preventing and treating radopholus similis | |
| CN103734168A (en) | Insecticidal pesticide formulation containing biopesticide-rotenone | |
| CN104585186A (en) | Insecticidal composition containing trichloropenyl pyrimidine and biogenic source | |
| CN103385242B (en) | A kind of Pesticidal combination containing CGA 183893 and biogenic substances | |
| CN103503876B (en) | A kind of brominated worm Benzoylamide and the Pesticidal combination of neires toxin | |
| CN103734167B (en) | A kind of pesticidal preparations preventing and treating Bemisia tabaci containing fluorine pyridine worm amine nitrile | |
| CN105746526B (en) | A kind of Pesticidal combination for containing four chlorantraniliproles and biogenic substances | |
| CN103563956B (en) | Insecticidal composition containing propylene glycol alginate and carbamates | |
| CN107006497A (en) | A kind of bactericidal composition containing volution bacterium amine and jamaicin |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150408 |