CN107347908A - A kind of compound Avermectins compound finish of ultra-low volume fosthiazate and preparation method - Google Patents
A kind of compound Avermectins compound finish of ultra-low volume fosthiazate and preparation method Download PDFInfo
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- CN107347908A CN107347908A CN201710719305.1A CN201710719305A CN107347908A CN 107347908 A CN107347908 A CN 107347908A CN 201710719305 A CN201710719305 A CN 201710719305A CN 107347908 A CN107347908 A CN 107347908A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
- A01N57/26—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-nitrogen bonds
- A01N57/32—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-nitrogen bonds containing heterocyclic radicals
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
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Abstract
The present invention provides a kind of compound Avermectins compound finish of ultra-low volume fosthiazate and preparation method, belong to agriculture pharmaceutical technology field, the finish is to utilize 1~20 part of fosthiazate, AVM or emamectin benzoate, 1~50 part of cosolvent, 1~30 part of bleeding agent, solvent complements to the proportioning of 100 parts of formula and its parts by weight altogether, by cosolvent, AVM and partial solvent are added in the mixing kettle with high-speed stirring apparatus, at a temperature of 20~50 DEG C, it is uniformly mixed, fosthiazate mixing is added portionwise, bleeding agent is added portionwise, after being uniformly mixed, it is cooled to room temperature, remaining solvent is added portionwise, it is well mixed, transparent oily liquids is finished product.The finish of the present invention, is mainly used in aircraft ultra-low volume spray, it can also be used to ground ultra-low volume spray.It is nontoxic, pollution-free from biological organic solvent.Work efficiency is high, save medication, preventing and treating is timely, low without water, expenses for prevention and control.Bright preparation method is simple, practical.
Description
Technical field
The present invention relates to agriculture pharmaceutical technology field, specifically a kind of compound Avermectins of ultra-low volume fosthiazate
Compound finish and preparation method.
Background technology
Fosthiazate is Japanese Shi Yuan companies in June, 1985 registration patent (clear 60-104096), launch within 1992 one
Kind novelty, efficient, wide spectrum, safety nematicide and the agricultural chemicals for killing subterranean pest-insect, it is right to root-knot nematode, pratylenchus special efficacy
Insect, mite class positive effect, there is extraordinary preventing and treating to make to tobacco, peanut, soybean, citrus, the nematode of vegetables and subterranean pest-insect
With.Fosthiazate, which has, tags and new and effective, the less toxic nematode killing agent of Uptake and translocation performance, can effectively prevent nematode invaded plantses body
Interior and kill the nematode in invaded plantses body, the lasting period, application effect was not influenceed by edaphic condition up to 2~3 months.
The molecular formula of fosthiazate is C9H18NO3PS2, structural formula is：
Chemical name is (R, S)-S- sec-butyls-O- ethyl-2-oxos -1,3-thiazoles alkane -3- base thiophosphates, sterling
Outward appearance is weak yellow liquid.The granule of fosthiazate is unstable, easy decomposition, and fosthiazate has unhappy smell, and smell is protected
The time is stayed to grow, it is difficult to eliminate, thus have impact on the use of fosthiazate to a certain extent.
With the development of modern society, aircraft spraying medicine is more and more more, and at present, the preparation of fosthiazate mainly has 20% and 40%
Aqueous emulsion, 5.5%, 10%, 15% granule, 5% microemulsion, 30% microcapsule suspending agent, 5% soluble concentrate,
These preparations using when formulation rate is big, labor intensity is big and environment is polluted.Current fosthiazate preparation can not meet
Social demand.
Ultra low volume spray is a kind of good technology for being applied to preventing and treating agriculture and forestry injurious insect.The new technology sprays without using water
Fogdrop diameter very little, prevention effect is good, saving of work and time, be particularly suitable for use in mountain region and water shortage, few water area.Simultaneously because big face
After product aircraft ultra-low volume preventing and treating new technology occurs, insect population is forced down to rapid, control fulminant insect serves decisive role.But
It is few to be applicable medicament kind, without approved product, ultra-low volume sprinkling is restricted, and directly affects the further raising of prevention and control capability.
The content of the invention
The technical assignment of the present invention is that solve the deficiencies in the prior art, there is provided a kind of ultra-low volume fosthiazate finish and its multiple
Close Avermectins compound finish and preparation method.
AVM, English name Avermectins, by streptomyces griseus Streptomyces in streptomycete
Avermitilis fermentations produce, and are made up of one group of ten hexa-atomic Macrocyclic lactone compounds, have stomach toxicity to mite class and insect and tag
Effect, it is impossible to ovicidal, for the efficient, antibiotic insecticide of wide spectrum.The former medicine of AVM is white or pale yellow crystals powder,
Fusing point is 157-162 DEG C, and dissipation can be decomposed rapidly by spraying leaf surface, when the active ingredient penetrated into plant parenchymal tissue can be longer
Between be present in tissue and there is conduction, the insect endangered feeding in evil mite and plant tissue has long residual effect, mainly
For epizoa and crop pests in poultry, domestic animal body, such as parasitic red worm, Diptera, coleoptera, Lepidoptera and pest mite
Deng.
Emamectin benzoate (full name：Emamectin-benzoate), white or light yellow crystalline powder, it is dissolved in acetone and first
Alcohol, it is slightly soluble in water, insoluble in hexane.It is a kind of new and effective semi-synthetic antibiosis synthesized since fermented product AVERMECTIN B1
Element pesticide, it has the characteristics of biological pesticide such as ultra high efficiency, low toxicity (preparation is closely nontoxic), low-residual, nuisanceless..Emamectin benzoate
There is very high activity to many insects, especially to Lepidoptera, Diptera, ultra high efficiency, such as red tape leaf roller, cigarette aphid noctuid, cotton
Earworm, maduca sexta, diamondback moth mythimna separata, beet armyworm, nonirrigated farmland Beet armyworm, cabbage looper, cabbage looper, cabbage butterfly, dish
Heart snout moth's larva, wild cabbage horizontal stripe snout moth's larva, tomato hawkmoth, colorado potato bug, Mexico ladybug etc..Emamectin benzoate by acidity it is too high or too low,
Illumination etc. is easy to degrade when influenceing.
The technical scheme is that realize in the following manner, a kind of ultra-low volume fosthiazate-AVM finish,
It is to utilize 1~20 part of fosthiazate, 0.1~10 part of AVM, 1~50 part of cosolvent, 1~30 part of bleeding agent, solvent complements to
The proportioning of 100 parts of formula and its parts by weight altogether, cosolvent, AVM and partial solvent are added and filled with high-speed stirred
In the mixing kettle put, at a temperature of 20~50 DEG C, it is uniformly mixed, fosthiazate mixing is added portionwise, bleeding agent is added portionwise,
After being uniformly mixed, room temperature is cooled to, remaining solvent is added portionwise, is well mixed, transparent oily liquids is finished product.
Fosthiazate uses mass concentration 95wt% fosthiazate crude oil, and formula rate is 1.05~10.53 parts, preferably 95wt%
Fosthiazate crude oil, formula rate are 1.05~5.26 parts.
Cosolvent uses：Cyclohexanone, ethylene glycol monomethyl ether, isophorone, METHYLPYRROLIDONE, dimethylformamide,
It is one or more kinds of mixed in dimethyl sulfoxide (DMSO), 3- methoxyl group -2- cyclohexene -1- ketone, toluene, dimethylbenzene, butyl acetate
Compound；The proportioning of cosolvent uses 10~20 parts.
Bleeding agent uses：N-dodecylpyrrolidone, AEO, APES, fat
The oxirane of alcohol and the block polymer of expoxy propane, aliphatic alcohol polyoxyvinethene phosphate (or salt), alkyl phenol polyoxy second
One or more kinds of mixtures in alkene ether phosphate (or salt), phenethyl phenol polyethenoxy ether, sapn, tween；Infiltration
The proportioning of agent uses 4~8 parts.
Solvent uses：Higher fatty acids esters, aromatic hydrocarbon solvent, isoparaffic solvent, kerosene, biodiesel, naphthenic oil,
Castor oil, C10~C18One or more kinds of mixtures in heavy aromatic solvent, methyl naphthalene solvent, farming soluble composite ester.
Preparation method：The finish is to utilize 1~10 part of fosthiazate, 0.1~5 part of AVM, 1~30 part of cosolvent, is oozed
Saturating 1~10 part of agent, solvent supply 100 parts of formula and its proportioning of parts by weight, cosolvent, AVM and partial solvent are added
Enter in the mixing kettle with high-speed stirring apparatus, at a temperature of 20~50 DEG C, be uniformly mixed, fosthiazate is added portionwise and mixes
It is even, bleeding agent is added portionwise, after being uniformly mixed, is cooled to room temperature, remaining solvent is added portionwise, is well mixed, in saturating
Bright oily liquids is finished product.
A kind of preparation method of ultra-low volume fosthiazate-emamectin benzoate finish is that the finish is to utilize 1~10 part of fosthiazate,
0.1~2. part of emamectin benzoate, cosolvent~30 part, 1~10 part, solvent complements to matching somebody with somebody for 100 parts of formula altogether and its parts by weight
Than, cosolvent, emamectin benzoate and partial solvent are added in the mixing kettle with high-speed stirring apparatus, at a certain temperature, stirring
It is well mixed, fosthiazate mixing is added portionwise, bleeding agent is added portionwise, is uniformly mixed, is cooled to room temperature, is added portionwise remaining
Under solvent, be well mixed, transparent oily liquids is finished product.
The caused compared with prior art beneficial effect of the present invention is：
The ultra-low volume fosthiazate finish and its compound Avermectins compound finish and preparation method
(1) finish of the invention, is mainly used in aircraft ultra-low volume spray, it can also be used to ground ultra-low volume spray.
(2) present invention selects biological organic solvent, nontoxic, pollution-free.
(3) work efficiency is high, save medication, preventing and treating is timely, low without water, expenses for prevention and control.
(4) preparation method of the present invention is simple, practical.
(5) preparation stabilization, stable effective ingredients.
(6) it is in extensive range to murder worm.
The compound Avermectins compound finish of the ultra-low volume fosthiazate and preparation method is reasonable in design, technique is simple
It is single, safe and reliable, easy to use, be easy to grasp, have good value for applications.
Embodiment
Below to a kind of compound Avermectins compound finish of ultra-low volume fosthiazate and preparation method of the present invention
It is described in detail below.
A kind of ultra-low volume fosthiazate-AVM finish of the present invention, 1.0%-10.0% containing fosthiazate, AVM
0.1%-5.0% single-phase transparent oily liquid, 50 μm -100 μm of its finish fogdrop diameter, diffusion ratio 0.60-0.90, viscosity
For (25 ± 1) DEG C when (1.40-1.90) × 10-3Pas, it is 1.040-1.096 during relative density (20 ± 1) DEG C, heat storage is stable
Property 54 DEG C at store 14d without precipitation, crystallization and lamination, resolution ratio≤0.2%, low-temperature stability store 48h at -5 DEG C
Without precipitation, crystallization and without floating object.
The formula of ultra-low volume fosthiazate-AVM finish is：
Fosthiazate crude oil (95% fosthiazate crude oil) 1.05%-10.53%, (95% AVM is former for the former medicine of AVM
Medicine) 0.11%-5.26%, cosolvent 1.0%-30.0%, bleeding agent 1.0%-10.0%, solvent supplies 100%.
Fosthiazate crude oil, preferably 95% fosthiazate crude oil, formula rate (wt%) are 1.05%-10.53%, further excellent
It is 1.05%-5.26% to select 95% fosthiazate crude oil formula rate (wt%).
Selected the former medicine of AVM, preferably 95% the former medicine of AVM, formula rate (wt%) are 0.11%-
5.26%, further preferred the former medicine of AVM formula rate (wt%) is 0.21%-2.11%.
Cosolvent cyclohexanone or ethylene glycol monomethyl ether or isophorone or pyrrolidones or dimethylformamide or 3- methoxyl groups-
2- cyclohexene -1- ketone or toluene or dimethylbenzene or butyl acetate or dimethyl sulfoxide (DMSO).
Bleeding agent is N-dodecylpyrrolidone or AEO or APES or fat
The oxirane of alcohol and the block polymer of expoxy propane or aliphatic alcohol polyoxyvinethene phosphate (or salt) or alkyl phenol polyoxy
Ethene ether phosphate (or salt) or phenethyl phenol polyethenoxy ether or Span series or TWEEN Series.
Solvent is higher fatty acids esters or aromatic hydrocarbon solvent series or isoparaffic solvent series or kerosene or biological bavin
Oil or naphthenic oil or castor oil or C10~C18 heavy aromatic solvents series or methyl naphthalene solvent series or farming soluble composite ester.
A kind of preparation method of ultra-low volume fosthiazate-AVM finish is according to formula rate, by cosolvent, Avermectin
Plain active compound and partial solvent are added in the mixing kettle with high-speed stirring apparatus, at a certain temperature, are uniformly mixed, in batches
Add fosthiazate crude oil to mix, bleeding agent is added portionwise, after being uniformly mixed, is cooled to room temperature, is added portionwise remaining molten
Agent, it is well mixed, transparent oily liquids is finished product.
Embodiment 1：
By dimethyl sulfoxide (DMSO) 2.00kg (1.82L), 95% the former medicine of AVM 0.11kg and methyl laurate 10.00kg
(11.50L) is added in the mixing kettle with high-speed stirring apparatus, is being heated to 30 DEG C, is being uniformly mixed, and adds 95% thiazole
Phosphine crude oil 1.05kg is mixed, and point 2 batches (every a batches about 1/2, after being well mixed, add next group) add N- dodecyl pyrrolidines
Ketone amounts to 1.00kg, is uniformly mixed, and is cooled to room temperature, point 5 batches (every batches about 1/5, after being well mixed, add next group)
Remaining methyl laurate 85.84kg (98.67L) is added, after being well mixed, transparent oily liquids is finished product.Finished product
Main performance index such as table 1.
The main performance index of the finished product of table 1
Note：
Volatility determines its volatility with filter paper suspension method：Take 0.8-1.0mL to predict finish with syringe, uniformly drop in flat
On the qualitative filter paper for the diameter 11cm with copper wire ring to weigh in advance put, filter paper is wet through, weigh immediately, be suspended on
Take out and weigh in the insulating box of (30 ± 1) DEG C, after 20min, obtain decoction volatility.It is strong more than 30%, between 10%-30%
For in, less than 10% to be weak.
Viscosity is with NDJ-79 types Rotary Viscosimeter in (25 ± 1) DEG C measure.
Finish fogdrop diameter, diffusion ratio measure：Under the outdoor nearly calm condition of flat open area of selection one, 3WCD-5 is used
Fixed hand electric ultra-low-volume sprayer spraying, 45 ° of spray angle, spray time 1min；Spread of spray is 15m × 12m, uses oxygen
Change magnesium slide and receive droplet, length and width set slide by 1m spacing, and spraying terminates rear 10min and starts to receive slide, 3 repetitions.Root
According to slide droplet volumetric median diameter, quantity central diameter and diffusion ratio are calculated by medicine number.
Heat storage stability by chromatography determination (Liu Xiuming, Liu Yufa etc., gas chromatography determine fosthiazate content,
Agricultural chemicals, 11 phases in 2009；Liu Kui, the RP-HPLC analyses of green novel form pesticide avermectin effervescent tablet, agricultural chemicals, 2007
08 phase of year).
Embodiment 2：
By cyclohexanone 30.00kg (31.58L), 95% the former medicine of AVM 1.05kg and ethyl laurate 10.00kg
(11.63L) is added in the mixing kettle with high-speed stirring apparatus, is being heated to 30 DEG C, is being uniformly mixed, and adds 95% thiazole
Phosphine crude oil 1.05kg is mixed, and point 2 batches (every a batches about 1/2, after being well mixed, add next group) add N- dodecyl pyrrolidines
Ketone amounts to 2.00kg, is uniformly mixed, and is cooled to room temperature, point 5 batches (every batches about 1/5, after being well mixed, add next group)
Remaining ethyl laurate 55.90kg (65.00L) is added, after being well mixed, transparent oily liquids is finished product.Finished product
Main performance index such as table 2.
The main performance index of the finished product of table 2
Embodiment 3：
By isophorone 20.00kg (21.67L), 95% the former medicine of AVM 0.21kg and ethyl laurate 20.00kg
(23.26L) is added in the mixing kettle with high-speed stirring apparatus, is being heated to 40 DEG C, is being uniformly mixed, and adds 95% thiazole
Phosphine crude oil 2.11kg is mixed, and point 3 batches (every a batches about 1/3, after being well mixed, add next group) add OP-4 and amount to 10.00kg,
It is uniformly mixed, is cooled to room temperature, point 5 batches (every a batches about 1/5, after being well mixed, add next group) adds the remaining moon
Ethyl cinnamate 47.68kg (55.44L), after being well mixed, transparent oily liquids is finished product.The main performance index of finished product
Such as table 3.
The main performance index of the finished product of table 3
Embodiment 4：
By METHYLPYRROLIDONE 10.00kg (9.75L), 95% the former medicine of AVM 0.53kg and methyl oleate
30.00kg (22.88L) is added in the mixing kettle with high-speed stirring apparatus, is being heated to 40 DEG C, is being uniformly mixed, and is added
95% fosthiazate crude oil 2.11kg is mixed, and point 3 batches (every a batches about 1/3, next group is added after well mixed) add OP-4 and amounted to
5.00kg, it is uniformly mixed, is cooled to room temperature, more than point 5 batches of (every a batches about 1/5, next group is added after well mixed) addition
Under ethyl laurate 52.36kg (60.88L), be well mixed after, transparent oily liquids is finished product.The main property of finished product
Can index such as table 4.
The main performance index of the finished product of table 4
Embodiment 5：
By ethylene glycol monomethyl ether 5.00kg (5.15L), 95% the former medicine of AVM 0.53kg and soya oil acid methyl ester 20.00kg
(22.99L) is added in the mixing kettle with high-speed stirring apparatus, is being heated to 30 DEG C, is being uniformly mixed, and dividing 3 batches, (every batch about
1/3, add next group after well mixed) 95% fosthiazate crude oil 5.26kg mixings are added, dividing 3 batches, (every batch about 1/3, mix
Next group is added after uniformly) add OP-10 and amount to 2.00kg, it is uniformly mixed, is cooled to room temperature, point 5 batches (every batch about 1/
5, add next group after well mixed) remaining soya oil acid methyl ester 67.21kg (77.25L) is added, after being well mixed, in saturating
Bright oily liquids is finished product.The main performance index of finished product such as table 5.
The main performance index of the finished product of table 5
Embodiment 6：
By 3- methoxyl group -2- cyclohexene -1- ketone 10.00kg (9.71L), 95% the former medicine of AVM 2.11kg and palm oil
Sour methyl esters 30.00kg (34.28L) is added in the mixing kettle with high-speed stirring apparatus, is being heated to 40 DEG C, is stirred
Even, point 5 batches (every a batches about 1/5, next group is added after well mixed) add 95% fosthiazate crude oil 10.53kg and mixed, and divide 2 batches
(every batch about 1/2, after being well mixed, add next group) adds AEO AEO-3 and amounts to 2.00kg, and stirring is mixed
Close uniformly, be cooled to room temperature, point 5 batches (every a batches about 1/5, next group is added after well mixed) add remaining palmitoleic acid first
Ester 45.36kg (51.84L), after being well mixed, transparent oily liquids is finished product.The main performance index of finished product such as table 6.
The main performance index of the finished product of table 6
Embodiment 7：
By alpha-methyl-naphthalene solvent 10.00kg (9.80L), 95% the former medicine of AVM 1.05kg and biodiesel 20.00kg
(24.39L) is added in the mixing kettle with high-speed stirring apparatus, is being heated to 50 DEG C, is being uniformly mixed, and dividing 5 batches, (every batch about
1/5, add next group after well mixed) 95% fosthiazate crude oil 10.53kg mixings are added, dividing 3 batches, (every batch about 1/3, mix
Uniformly after add next group) add AEO AEO-7 amount to 10.00kg, be uniformly mixed, be cooled to room
Temperature, point 5 batches (every a batches about 1/5, next group is added after well mixed) add remaining biodiesel 48.48kg (59.12L),
After well mixed, transparent oily liquids is finished product.The main performance index of finished product such as table 7.
The main performance index of the finished product of table 7
Embodiment 8：
By METHYLPYRROLIDONE 20.00kg (19.50L), 95% the former medicine of AVM 0.11kg and farming soluble composite ester
20.00kg (22.73L) is added in the mixing kettle with high-speed stirring apparatus, is being heated to 50 DEG C, is being uniformly mixed, and divides 5 batches
(every batch about 1/5, next group is added after well mixed) adds 95% fosthiazate crude oil 10.53kg and mixed, and dividing 3 batches, (every batch about
1/3, next group is added after well mixed) add AEO AEO-9 and amount to 10.00kg, it is uniformly mixed,
Room temperature is cooled to, point 3 batches (every a batches about 1/3, next group is added after well mixed) add remaining farming soluble composite ester 39.36kg
(44.73L), after being well mixed, transparent oily liquids is finished product.The main performance index of finished product such as table 8.
The main performance index of the finished product of table 8
Embodiment 9：
By butyl acetate 10.00kg (11.33L), 95% the former medicine of AVM 0.53kg and biodiesel 20.00kg
(24.39L) is added in the mixing kettle with high-speed stirring apparatus, is being heated to 45 DEG C, is being uniformly mixed, and dividing 5 batches, (every batch about
1/5, add next group after well mixed) 95% fosthiazate crude oil 10.53kg mixings are added, dividing 3 batches, (every batch about 1/3, mix
Uniformly after add next group) add AEO AEO-7 amount to 8.00kg, be uniformly mixed, be cooled to room
Temperature, point 5 batches (every a batches about 1/5, next group is added after well mixed) add remaining biodiesel 50.95kg (61.13L),
After well mixed, transparent oily liquids is finished product.The main performance index of finished product such as table 9.
The main performance index of the finished product of table 9
Embodiment 10：
By dimethylformamide 20.00kg (21.19L), 95% the former medicine of AVM 0.21kg and farming soluble composite ester
20.00kg (22.73L) is added in the mixing kettle with high-speed stirring apparatus, is being heated to 50 DEG C, is being uniformly mixed, and divides 5 batches
(every batch about 1/5, next group is added after well mixed) adds 95% fosthiazate crude oil 10.53kg and mixed, and dividing 3 batches, (every batch about
1/3, next group is added after well mixed) add AEO AEO-9 and amount to 6.00kg, it is uniformly mixed,
Room temperature is cooled to, point 3 batches (every a batches about 1/3, next group is added after well mixed) add remaining farming soluble composite ester 43.26kg
(49.16L), after being well mixed, transparent oily liquids is finished product.The main performance index of finished product such as table 10.
The main performance index of the finished product of table 10
Embodiment 11 is by dimethylbenzene 5.00kg (5.82L), 95% the former medicine of AVM 5.26kg and ethyl laurate
20.00kg (23.26L) is added in the mixing kettle with high-speed stirring apparatus, is being heated to 30 DEG C, is being uniformly mixed, and divides 3 batches
(every batch about 1/3, next group is added after well mixed) adds 95% fosthiazate crude oil 5.26kg and mixed, and divides 2 batches (every batch about 1/
2, next group is added after well mixed) add Span-80 and amount to 2.00kg, it is uniformly mixed, is cooled to room temperature, points 5 batches
(every batch about 1/5, next group is added after well mixed) adds remaining ethyl laurate 62.48kg (72.65L), and mixing is equal
After even, transparent oily liquids is finished product.The main performance index of finished product such as table 11.
The main performance index of the finished product of table 11
Embodiment 12 is by isophorone 20.00kg (21.67L), 95% the former medicine of AVM 0.21kg and ethyl laurate
20.00kg (23.26L) is added in the mixing kettle with high-speed stirring apparatus, is being heated to 40 DEG C, is being uniformly mixed, and divides 2 batches
(every batch about 1/2, next group is added after well mixed) adds 95% fosthiazate crude oil 2.11kg and mixed, and divides 3 batches (every batch about 1/
3, next group is added after well mixed) add Tween-20 and amount to 10.00kg, it is uniformly mixed, is cooled to room temperature, points 5
Criticize (every batch about 1/5, next group is added after well mixed) and add remaining ethyl laurate 47.68kg (55.44L), mixing
After uniformly, transparent oily liquids is finished product.The main performance index of finished product such as table 12.
The main performance index of the finished product of table 12
Embodiment 13 is by 3- methoxyl group -2- cyclohexene -1- ketone 10.00kg (9.71L), 95% the former medicine of AVM 1.05kg
Added with Methyl palmitoleinate 30.00kg (34.28L) in the mixing kettle with high-speed stirring apparatus, be heated to 40 DEG C, stirring
Well mixed, point 2 batches (every a batches about 1/2, next group is added after well mixed) add 95% fosthiazate crude oil 2.11kg and mixed,
2 batches (every batches about 1/2, after being well mixed, add next group) are divided to add calcium dodecyl benzene sulfonate (agriculture breasts 500#) amount to
2.00kg, it is uniformly mixed, is cooled to room temperature, more than point 5 batches of (every a batches about 1/5, next group is added after well mixed) addition
Under Methyl palmitoleinate 54.84kg (62.67L), be well mixed after, transparent oily liquids is finished product.Finished product it is main
Performance indications such as table 13.
The main performance index of the finished product of table 13
Embodiment 14 is by alpha-methyl-naphthalene solvent 10.00kg (9.80L), 95% the former medicine of AVM 5.26kg and biodiesel
20.00kg (24.39L) is added in the mixing kettle with high-speed stirring apparatus, is being heated to 50 DEG C, is being uniformly mixed, and divides 2 batches
(every batch about 1/2, next group is added after well mixed) adds 95% fosthiazate crude oil 1.05kg and mixed, and divides 3 batches (every batch about 1/
3, add next group after well mixed) add agriculture breast 670#10.00kg altogether, it is uniformly mixed, is cooled to room temperature, divides 5
Criticize (every batch about 1/5, next group is added after well mixed) and add remaining biodiesel 53.69kg (65.48L), mixing is equal
After even, transparent oily liquids is finished product.The main performance index of finished product such as table 14.
The main performance index of the finished product of table 14
Embodiment 15：
By METHYLPYRROLIDONE 10.00kg (9.75L), 95% the former medicine of AVM 0.32kg and farming soluble composite ester
20.00kg (22.73L) is added in the mixing kettle with high-speed stirring apparatus, is being heated to 50 DEG C, is being uniformly mixed, and divides 2 batches
(every batch about 1/2, next group is added after well mixed) adds 95% fosthiazate crude oil 5.26kg and mixed, and divides 3 batches (every batch about 1/
3, add next group after well mixed) add agriculture breast 650#10.00kg altogether, it is uniformly mixed, is cooled to room temperature, divides 3
Criticize (every batch about 1/3, next group is added after well mixed) and add remaining farming soluble composite ester 54.42kg (61.84L), mixing
After uniformly, transparent oily liquids is finished product.The main performance index of finished product such as table 15.
The main performance index of the finished product of table 15
Embodiment 16：
By butyl acetate 10.00kg (11.33L), 95% the former medicine of AVM 1.05kg and biodiesel 20.00kg
(24.39L) is added in the mixing kettle with high-speed stirring apparatus, is being heated to 45 DEG C, is being uniformly mixed, and dividing 3 batches, (every batch about
1/3, add next group after well mixed) 95% fosthiazate crude oil 5.26kg mixings are added, dividing 3 batches, (every batch about 1/3, mix
Uniformly after add next group) add AEO AEO-7 amount to 8.00kg, be uniformly mixed, be cooled to room
Temperature, point 5 batches (every a batches about 1/5, next group is added after well mixed) add remaining biodiesel 55.39kg (67.55L),
After well mixed, transparent oily liquids is finished product.The main performance index of finished product such as table 16.
The main performance index of the finished product of table 16
Embodiment 17：
By dimethylformamide 20.00kg (21.19L), 95% the former medicine of AVM 2.11kg and farming soluble composite ester
20.00kg (22.73L) is added in the mixing kettle with high-speed stirring apparatus, is being heated to 50 DEG C, is being uniformly mixed, and divides 3 batches
(every batch about 1/3, next group is added after well mixed) adds 95% fosthiazate crude oil 5.26kg and mixed, and divides 3 batches (every batch about 1/
3, add next group after well mixed) add agriculture breast 603#6.00kg altogether, it is uniformly mixed, is cooled to room temperature, divides 3 batches
(every batch about 1/3, next group is added after well mixed) adds remaining farming soluble composite ester 44.53kg (50.60L), and mixing is equal
After even, transparent oily liquids is finished product.The main performance index of finished product such as table 17.
The main performance index of the finished product of table 17
Embodiment 18：
By dimethylbenzene 5.00kg (1.16L), 95% the former medicine of AVM 3.16kg and ethyl laurate 20.00kg
(23.26L) is added in the mixing kettle with high-speed stirring apparatus, is being heated to 30 DEG C, is being uniformly mixed, and dividing 3 batches, (every batch about
1/3, add next group after well mixed) 95% fosthiazate crude oil 5.26kg mixings are added, dividing 2 batches, (every batch about 1/2, mix
Next group is added after uniformly) add agriculture breast 601#2.00kg altogether, it is uniformly mixed, is cooled to room temperature, divides 5 batches (every batch
About 1/5, add next group after well mixed) remaining ethyl laurate 64.58kg (75.09L) is added, after being well mixed,
Transparent oily liquids is finished product.The main performance index of finished product such as table 18.
The main performance index of the finished product of table 18
Embodiment 19：
By isophorone 20.00kg (21.67L), 95% the former medicine of AVM 3.16kg and ethyl laurate 20.00kg
(23.26L) is added in the mixing kettle with high-speed stirring apparatus, is being heated to 40 DEG C, is being uniformly mixed, and dividing 3 batches, (every batch about
1/3, after being well mixed, add next group) 95% fosthiazate crude oil 3.16kg mixings are added, dividing 3 batches, (every batch about 1/3, mix
After uniformly, next group is added) add agriculture breast 602#10.00kg altogether, it is uniformly mixed, is cooled to room temperature, divides 5 batches (often
About 1/5 is criticized, after being well mixed, adds next group) remaining ethyl laurate 43.68kg (50.79L) is added, it is well mixed
Afterwards, transparent oily liquids is finished product.The main performance index of finished product such as table 19.
The main performance index of the finished product of table 19
The determination of activity of embodiment 20：
Meloidogyne incognita (Meloidogyne incognita) second instar larvae suspension of certain volume is taken to be put into culture
In ware (F6cm), the reagent agent of doses is sprayed, often processing is repeated 4 times, often repeatedly 30 nematodes, using clear water as blank pair
According to.During 25 DEG C of culture 24h, 48h check respectively for death and the survival condition of nematode, calculate each chemicals treatment to the age of root-knot nematode two
The relative lethality of larva.
Dead nematode polypide is often stiff, bending is in arciform or screw type, and living nematode bends or twisted mostly, if it is determined that
When stiff nematode is had any problem anyway, nematode to be identified can be placed in 2% sodium chloride solution, be observed again after 2min, dead worm
It is stiff, worm curling or twisting living.
Experimental result is shown in Table 20, nemic death rate and nematode corrected mortality computational methods such as following formula.
Nemic death rate (%)=100 × (verge of death borer population/confession examination nematode number)
Nematode corrected mortality (%)=1003 (treatment group nemic death rate-control group nemic death rate)/(1- control groups
Nemic death rate)
The sample activity measurement result of table 20
Note:All data are the average value of four repetitions.
According to experimental result (being shown in Table 20), dosage and effect, cost of material, optimum fosthiazate-AVM
The formulation of finish is：The AVM finish of 5.0% fosthiazate -0.5% (preparation dosage 3g/m2), the Ah of 5.0% fosthiazate -1.0%
Tie up rhzomorph finish (preparation dosage 3g/m2), using effect is good, and preparation dosage is few, and preparation dosage is only fosthiazate granule (10%
The dosage of fosthiazate granule is 30kg/hm2, in hole week, 10% fosthiazate granule is tried the field efficacy of tomato root-knot eelworm
Test, agricultural chemicals, 2014 (10):765-766；The dosage of 10% fosthiazate granule is 1.5kg/667m2, Ding Xufeng, 10% thiazole
Phosphine granule prevents and treats the cucumber root-knot nematode test of pesticide effectiveness, Shanghai vegetables, 2014 (6):75-76) dosage (it is pure to be converted into fosthiazate
Product) 50%-70%.
AVM, emamectin benzoate participate in preparing ultra-low volume fosthiazate finish as compound Avermectins compound.
A kind of ultra-low volume fosthiazate-emamectin benzoate finish of the present invention, 1.0%-10.0% containing fosthiazate, emamectin benzoate
0.1%-2.0% single-phase transparent oily liquid, 50 μm -100 μm of its finish fogdrop diameter, diffusion ratio 0.60-0.90, viscosity
For (25 ± 1) DEG C when (1.30-1.79) 310-3Pa s, it is 1.053-1.096 during relative density (20 ± 1) DEG C, heat storage is stable
Property 54 DEG C at store 14d without precipitation, crystallization and lamination, resolution ratio≤0.2%, low-temperature stability store 48h at -5 DEG C
Without precipitation, crystallization and without floating object.
The formula of ultra-low volume fosthiazate-emamectin benzoate finish is：
Fosthiazate 1.0%-10.0% (95% fosthiazate crude oil 1.05%-10.53%), emamectin benzoate 0.1%-2.0%
(95% emamectin benzoate active compound 0.11%-2.11%), cosolvent 1.0%-30.0%, bleeding agent 1.0%-10.0%, solvent are supplied
100%.
Fosthiazate crude oil, preferably 95% fosthiazate crude oil, formula rate (wt%) are 1.05%-10.53%, further excellent
It is 1.05%-5.26% to select 95% fosthiazate crude oil formula rate (wt%).
Emamectin benzoate active compound, preferably 95% emamectin benzoate active compound, formula rate (wt%) are 0.11%-2.11%, further excellent
It is 0.53%-1.05% to select 95% emamectin benzoate active compound formula rate (wt%).
A kind of preparation method of ultra-low volume fosthiazate-emamectin benzoate finish of the present invention：According to formula rate, by hydrotropy
Agent, emamectin benzoate active compound and partial solvent are added in the mixing kettle with high-speed stirring apparatus, at a certain temperature, are stirred
It is even, the mixing of fosthiazate crude oil is added portionwise, bleeding agent is added portionwise, is uniformly mixed, is cooled to room temperature, remainder is added portionwise
Solvent, be well mixed, transparent oily liquids is finished product.
Embodiment 21：
By cyclohexanone 1.00kg (1.05L), 95% emamectin benzoate active compound 0.11kg and methyl laurate 10.00kg (11.50L)
Add in the mixing kettle with high-speed stirring apparatus, be heated to 30 DEG C, be uniformly mixed, add 95% fosthiazate crude oil
1.05kg is mixed, and point 2 batches (every a batches about 1/2, next group is added after well mixed) add N-dodecylpyrrolidone and amounted to
1.00kg, it is uniformly mixed, is cooled to room temperature, more than point 5 batches of (every a batches about 1/5, next group is added after well mixed) addition
Under methyl laurate 86.84kg (99.82L), be well mixed after, transparent oily liquids is finished product.The main property of finished product
Can index such as table 21.
The main performance index of the finished product of table 21
Note：
Volatility determines its volatility with filter paper suspension method：Take 0.8-1.0mL to predict finish with syringe, uniformly drop in flat
On the qualitative filter paper for the diameter 11cm with copper wire ring to weigh in advance put, filter paper is wet through, weigh immediately, be suspended on
Take out and weigh in the insulating box of (30 ± 1) DEG C, after 20min, obtain decoction volatility.It is strong more than 30%, between 10%-30%
For in, less than 10% to be weak.
Viscosity is with NDJ-79 types Rotary Viscosimeter in (25 ± 1) DEG C measure.
Finish fogdrop diameter, diffusion ratio measure：Under the outdoor nearly calm condition of flat open area of selection one, 3WCD-5 is used
Fixed hand electric ultra-low-volume sprayer spraying, 45 ° of spray angle, spray time 1min；Spread of spray is 15m312m, uses oxygen
Change magnesium slide and receive droplet, length and width set slide by 1m spacing, and spraying terminates rear 10min and starts to receive slide, 3 repetitions.Root
According to slide droplet volumetric median diameter, quantity central diameter and diffusion ratio are calculated by medicine number.
Heat storage stability by chromatography determination (Liu Xiuming, Liu Yufa etc., gas chromatography determine fosthiazate content,
Agricultural chemicals, 11 phases in 2009；Liu Liyun, the efficient liquid phase chromatographic analysis of 0.2% hypertonic emamectin benzoate missible oil, modern, 2007
03 phase).
Embodiment 22：By cyclohexanone 30.00kg (31.58L), 95% emamectin benzoate active compound 2.11kg and ethyl laurate
10.00kg (11.63L) is added in the mixing kettle with high-speed stirring apparatus, is being heated to 30 DEG C, is being uniformly mixed, and is added
95% fosthiazate crude oil 1.05kg is mixed, and point 3 batches (every a batches about 1/3, next group is added after well mixed) add N- dodecanes
Base pyrrolidones amounts to 4.00kg, is uniformly mixed, and is cooled to room temperature, and dividing 5 batches, (every batch about 1/5, add after well mixed
Next group) remaining ethyl laurate 52.84kg (61.44L) is added, after being well mixed, transparent oily liquids is finished product.
The main performance index of finished product such as table 22.
The main performance index of the finished product of table 22
Embodiment 23 is by cyclohexanone 30.00kg (31.58L), 95% emamectin benzoate active compound 0.11kg and ethyl laurate
10.00kg (11.63L) is added in the mixing kettle with high-speed stirring apparatus, is being heated to 30 DEG C, is being uniformly mixed, and is added
95% fosthiazate crude oil 1.05kg is mixed, and point 2 batches (every a batches about 1/2, next group is added after well mixed) add N- dodecanes
Base pyrrolidones amounts to 2.00kg, is uniformly mixed, and is cooled to room temperature, and dividing 5 batches, (every batch about 1/5, add after well mixed
Next group) remaining ethyl laurate 56.84kg (66.09L) is added, after being well mixed, transparent oily liquids is finished product.
The main performance index of finished product such as table 23.
The main performance index of the finished product of table 23
Embodiment 24 is by isophorone 20.00kg (21.67L), 95% emamectin benzoate active compound 0.21kg and ethyl laurate
20.00kg (23.26L) is added in the mixing kettle with high-speed stirring apparatus, is being heated to 40 DEG C, is being uniformly mixed, and is added
95% fosthiazate crude oil 2.11kg is mixed, and point 3 batches (every a batches about 1/3, after being well mixed, add next group) add OP-4 and amounted to
10.00kg, it is uniformly mixed, is cooled to room temperature, point 5 batches (every a batches about 1/5, after being well mixed, add next group) adds
Remaining ethyl laurate 47.68kg (55.44L), after being well mixed, transparent oily liquids is finished product.Finished product it is main
Performance indications such as table 24.
The main performance index of the finished product of table 24
Embodiment 25 is by METHYLPYRROLIDONE 10.00kg (9.75L), 95% emamectin benzoate active compound 0.21kg and oleic acid
Methyl esters 30.00kg (22.88L) is added in the mixing kettle with high-speed stirring apparatus, is being heated to 40 DEG C, is being uniformly mixed,
95% fosthiazate crude oil 2.11kg mixings are added, point 3 batches (every a batches about 1/3, next group is added after well mixed) add OP-4
5.00kg altogether, it is uniformly mixed, is cooled to room temperature, point 5 batches (every a batches about 1/5, next group is added after well mixed) adds
Enter remaining ethyl laurate 52.68kg (61.26L), after being well mixed, transparent oily liquids is finished product.The master of finished product
Want performance indications such as table 25.
The main performance index of the finished product of table 25
Embodiment 26 is by ethylene glycol monomethyl ether 5.00kg (5.15L), 95% emamectin benzoate active compound 0.53kg and soya oil acid methyl ester
20.00kg (22.99L) is added in the mixing kettle with high-speed stirring apparatus, is being heated to 30 DEG C, is being uniformly mixed, and divides 2 batches
(every batch about 1/2, next group is added after well mixed) adds 95% fosthiazate crude oil 5.26kg and mixed, and divides 2 batches (every batch about 1/
2, next group is added after well mixed) add OP-10 and amount to 2.00kg, it is uniformly mixed, is cooled to room temperature, points 5 batches is (every
About 1/5 is criticized, next group is added after well mixed) remaining soya oil acid methyl ester 67.21kg (77.25L) is added, it is well mixed
Afterwards, transparent oily liquids is finished product.The main performance index of finished product such as table 26.
The main performance index of the finished product of table 26
Embodiment 27 by 3- methoxyl group -2- cyclohexene -1- ketone 10.00kg (9.71L), 95% emamectin benzoate active compound 1.05kg and
Methyl palmitoleinate 30.00kg (34.28L) is added in the mixing kettle with high-speed stirring apparatus, is being heated to 40 DEG C, stirring is mixed
Close uniformly, point 4 batches (every a batches about 1/4, next group is added after well mixed) add 95% fosthiazate crude oil 10.53kg and mixed,
Add AEO AEO-3 and amount to 2.00kg, be uniformly mixed, be cooled to room temperature, points 5 batches (every batch about 1/5,
Next group is added after well mixed) remaining Methyl palmitoleinate 46.42kg (53.05L) is added, after being well mixed, in saturating
Bright oily liquids is finished product.The main performance index of finished product such as table 27.
The main performance index of the finished product of table 27
Embodiment 28 is by alpha-methyl-naphthalene solvent 10.00kg (9.80L), 95% emamectin benzoate active compound 1.05kg and biodiesel
20.00kg (24.39L) is added in the mixing kettle with high-speed stirring apparatus, is being heated to 50 DEG C, is being uniformly mixed, and divides 4 batches
(every batch about 1/4, next group is added after well mixed) adds 95% fosthiazate crude oil 10.53kg and mixed, and dividing 3 batches, (every batch about
1/3, next group is added after well mixed) add AEO AEO-7 and amount to 10.00kg, it is uniformly mixed,
Room temperature is cooled to, point 5 batches (every a batches about 1/5, next group is added after well mixed) add remaining biodiesel 48.42kg
(59.05L), after being well mixed, transparent oily liquids is finished product.The main performance index of finished product such as table 28.
The main performance index of the finished product of table 28
Embodiment 29 is molten by METHYLPYRROLIDONE 20.00kg (19.50L), 95% emamectin benzoate active compound 2.11kg and agriculture
Complex ester 20.00kg (22.73L) is added in the mixing kettle with high-speed stirring apparatus, is being heated to 50 DEG C, is stirred
Even, point 4 batches (every a batches about 1/4, next group is added after well mixed) add 95% fosthiazate crude oil 10.53kg and mixed, and divide 3 batches
(every batch about 1/3, next group is added after well mixed) adds AEO AEO-9 and amounts to 10.00kg, and stirring is mixed
Close uniformly, be cooled to room temperature, point 3 batches (every a batches about 1/3, next group is added after well mixed) add remaining farming soluble composite esters
37.36kg (42.45L), after being well mixed, transparent oily liquids is finished product.The main performance index of finished product such as table 29.
The main performance index of the finished product of table 29
Embodiment 30 is by butyl acetate 10.00kg (11.33L), 95% emamectin benzoate active compound 1.05kg and biodiesel
20.00kg (24.39L) is added in the mixing kettle with high-speed stirring apparatus, is being heated to 45 DEG C, is being uniformly mixed, and divides 5 batches
(every batch about 1/5, next group is added after well mixed) adds 95% fosthiazate crude oil 10.53kg and mixed, and dividing 3 batches, (every batch about
1/3, add next group after well mixed) add calcium dodecyl benzene sulfonate (agriculture breast 500#) amount to 8.00kg, it is stirred
Uniformly, room temperature is cooled to, point 5 batches (every a batches about 1/5, next group is added after well mixed) add remaining biodiesel
50.42kg (61.45L), after being well mixed, transparent oily liquids is finished product.The main performance index of finished product such as table 30.
The main performance index of the finished product of table 30
Embodiment 31 is molten compound by dimethylformamide 20.00kg (21.19L), 95% emamectin benzoate active compound 1.58kg and agriculture
Ester 20.00kg (22.73L) is added in the mixing kettle with high-speed stirring apparatus, is being heated to 50 DEG C, is being uniformly mixed, and divides 5
Criticize (every batch about 1/5, next group is added after well mixed) and add 95% fosthiazate crude oil 10.53kg mixings, divide 3 batches (every batch
About 1/3, next group is added after well mixed) add AEO AEO-9 and amount to 6.00kg, it is stirred
It is even, room temperature is cooled to, point 3 batches (every a batches about 1/3, next group is added after well mixed) add remaining farming soluble composite ester
41.89kg (47.60L), after being well mixed, transparent oily liquids is finished product.The main performance index of finished product such as table 31.
The main performance index of the finished product of table 31
Embodiment 32 is molten compound by dimethylformamide 20.00kg (21.19L), 95% emamectin benzoate active compound 0.11kg and agriculture
Ester 20.00kg (22.73L) is added in the mixing kettle with high-speed stirring apparatus, is being heated to 50 DEG C, is being uniformly mixed, and divides 5
Criticize (every batch about 1/5, next group is added after well mixed) and add 95% fosthiazate crude oil 10.53kg mixings, divide 3 batches (every batch
About 1/3, add next group after well mixed) add agriculture breast 602#5.00kg altogether, after being uniformly mixed, it is cooled to room
Temperature, point 3 batches (every a batches about 1/3, next group is added after well mixed) add remaining farming soluble composite ester 44.36kg
(50.41L), after being well mixed, transparent oily liquids is finished product.The main performance index of finished product such as table 32.
The main performance index of the finished product of table 32
Embodiment 33 is by dimethylbenzene 1.00kg (1.16L), 95% emamectin benzoate active compound 0.11kg and ethyl laurate 20.00kg
(23.26L) is added in the mixing kettle with high-speed stirring apparatus, is being heated to 30 DEG C, is being uniformly mixed, and adds 95% thiazole
Phosphine crude oil 1.05kg is mixed, and point 2 batches (every a batches about 1/2, next group is added after well mixed) add Span-80 and amounted to
2.00kg, after being uniformly mixed, room temperature is cooled to, point 5 batches (every a batches about 1/5, next group is added after well mixed) add
Remaining ethyl laurate 75.84kg (88.19L), after being well mixed, transparent oily liquids is finished product.Finished product it is main
Performance indications such as table 33.
The main performance index of the finished product of table 33
Embodiment 34 is by isophorone 20.00kg (21.67L), 95% emamectin benzoate active compound 0.21kg and ethyl laurate
20.00kg (23.26L) is added in the mixing kettle with high-speed stirring apparatus, is being heated to 40 DEG C, is being uniformly mixed, and is added
95% fosthiazate crude oil 2.11kg is mixed, and point 3 batches (every a batches about 1/3, next group is added after well mixed) add Tween-20
10.00kg altogether, after being uniformly mixed, room temperature is cooled to, point 5 batches (every batches about 1/5, next group is added after well mixed)
Remaining ethyl laurate 47.68kg (55.44L) is added, after being well mixed, transparent oily liquids is finished product.Finished product
Main performance index such as table 34.
The main performance index of the finished product of table 34
The determination of activity of embodiment 35
Meloidogyne incognita (Meloidogyne incognita) second instar larvae suspension of certain volume is taken to be put into culture
In ware (F6cm), the reagent agent of doses is sprayed, often processing is repeated 4 times, often repeatedly 30 nematodes, using clear water as blank pair
According to.During 25 DEG C of culture 24h, 48h check respectively for death and the survival condition of nematode, calculate each chemicals treatment to the age of root-knot nematode two
The relative lethality of larva.
Dead nematode polypide is often stiff, bending is in arciform or screw type, and living nematode bends or twisted mostly, if it is determined that
When stiff nematode is had any problem anyway, nematode to be identified can be placed in 2% sodium chloride solution, be observed again after 2min, dead worm
It is stiff, worm curling or twisting living.
Experimental result is shown in Table 15, nemic death rate and nematode corrected mortality computational methods such as following formula.
Nemic death rate (%)=1003 (verge of death borer population/confession examination nematode number)
Nematode corrected mortality (%)=1003 (treatment group nemic death rate-control group nemic death rate)/(1- control groups
Nemic death rate)
The sample activity measurement result of table 35
Note:All data are the average value of four repetitions.
According to experimental result (being shown in Table 35), dosage and effect, cost of material, optimum fosthiazate-emamectin benzoate oil
The formulation of agent is：The emamectin benzoate finish of 5.0% fosthiazate -0.5% (preparation dosage 3g/m2), the first of 10.0% fosthiazate -1.0% dimension
Salt finish (preparation dosage 2g/m2), using effect is good, and preparation dosage is few, and preparation dosage is only fosthiazate granula (10% thiazole
The dosage of phosphine granule is 30kg/hm2, in hole week, 10% fosthiazate granule is to the field control effectiveness test of tomato root-knot eelworm, agriculture
Medicine, 2014 (10):765-766；The dosage of 10% fosthiazate granule is 1.5kg/667m2, Ding Xufeng, 10% fosthiazate particle
Agent prevents and treats the cucumber root-knot nematode test of pesticide effectiveness, Shanghai vegetables, 2014 (6):75-76) dosage (being converted into fosthiazate sterling)
50%-70%.
Claims (9)
- A kind of 1. ultra-low volume fosthiazate-AVM finish, it is characterised in that the finish is to utilize 1~20 part of fosthiazate, Ah 0.1~10 part of rhzomorph of dimension, 1~50 part of cosolvent, 1~30 part of bleeding agent, solvent complement to 100 parts of formula and its weight altogether The proportioning of part, cosolvent, AVM and partial solvent are added in the mixing kettle with high-speed stirring apparatus, at 20~50 DEG C At a temperature of, it is uniformly mixed, fosthiazate mixing is added portionwise, bleeding agent is added portionwise, after being uniformly mixed, is cooled to room Temperature, remaining solvent is added portionwise, is well mixed, transparent oily liquids is finished product.
- A kind of 2. ultra-low volume fosthiazate-AVM finish according to claim 1, it is characterised in that：Fosthiazate is adopted With mass concentration 95wt% fosthiazate crude oil, formula rate is 1.05~10.53 parts, preferably 95wt% fosthiazates crude oil, recipe ratio Example is 1.05~5.26 parts.
- A kind of 3. ultra-low volume fosthiazate-AVM finish according to claim 1, it is characterised in that：Cosolvent is adopted With：Cyclohexanone, ethylene glycol monomethyl ether, isophorone, METHYLPYRROLIDONE, dimethylformamide, dimethyl sulfoxide (DMSO), 3- first One or more kinds of mixtures in epoxide -2- cyclohexene -1- ketone, toluene, dimethylbenzene, butyl acetate；Cosolvent is matched somebody with somebody Than using 10~20 parts.
- A kind of 4. ultra-low volume fosthiazate-AVM finish according to claim 1, it is characterised in that：Bleeding agent is adopted With：N-dodecylpyrrolidone, AEO, APES, the oxirane and ring of fatty alcohol Block polymer, aliphatic alcohol polyoxyvinethene phosphate (or salt), the APES phosphate (or salt) of Ethylene Oxide , phenethyl phenol polyethenoxy ether, sapn, one or more kinds of mixtures in tween；The proportioning of bleeding agent uses 4~8 Part.
- A kind of 5. ultra-low volume fosthiazate-AVM finish according to claim 1, it is characterised in that：Solvent uses： Higher fatty acids esters, aromatic hydrocarbon solvent, isoparaffic solvent, kerosene, biodiesel, naphthenic oil, castor oil, C10~C18Weight One or more kinds of mixtures in aromatic solvent, methyl naphthalene solvent, farming soluble composite ester.
- A kind of 6. ultra-low volume fosthiazate-AVM finish according to claim 1, it is characterised in that：The finish is Using 1~10 part of fosthiazate, 0.1~5 part of AVM, 1~30 part of cosolvent, 1~10 part of bleeding agent, solvent supplies 100 parts Formula and its parts by weight proportioning, by cosolvent, AVM and partial solvent add with high-speed stirring apparatus mixing In kettle, at a temperature of 20~50 DEG C, it is uniformly mixed, fosthiazate mixing is added portionwise, bleeding agent is added portionwise, is stirred After uniformly, room temperature is cooled to, remaining solvent is added portionwise, be well mixed, transparent oily liquids is finished product.
- A kind of 7. preparation method of ultra-low volume fosthiazate-AVM finish, it is characterised in that：The formula of the finish and its again Amount part proportioning be：1~10 part of fosthiazate, 0.1~5 part of AVM, 1~30 part of cosolvent, 1~10 part of bleeding agent, solvent 100 parts altogether are complemented to, preparation method is：Cosolvent, AVM and partial solvent are added with high-speed stirring apparatus In mixing kettle, at a temperature of 20~50 DEG C, it is uniformly mixed, fosthiazate mixing is added portionwise, bleeding agent is added portionwise, stirs After well mixed, room temperature is cooled to, remaining solvent is added portionwise, be well mixed, transparent oily liquids is finished product.
- A kind of 8. ultra-low volume fosthiazate-emamectin benzoate finish, it is characterised in that：The finish is to utilize 1~10 part of fosthiazate, first dimension 0.1~2. part of salt, cosolvent~30 part, 1~10 part, solvent complements to the proportioning of 100 parts of formula and its parts by weight altogether, will Cosolvent, emamectin benzoate and partial solvent are added in the mixing kettle with high-speed stirring apparatus, at a certain temperature, are stirred It is even, fosthiazate mixing is added portionwise, bleeding agent is added portionwise, is uniformly mixed, is cooled to room temperature, is added portionwise remaining molten Agent, it is well mixed, transparent oily liquids is finished product.
- A kind of 9. preparation method of ultra-low volume fosthiazate-emamectin benzoate finish, it is characterised in that：The finish is to utilize fosthiazate 1 ~10 parts, 0.1~2. part of emamectin benzoate, cosolvent~30 part, 1~10 part, solvent complements to 100 parts of formula and its weight altogether The proportioning of part, cosolvent, emamectin benzoate and partial solvent are added in the mixing kettle with high-speed stirring apparatus, in certain temperature Under, it is uniformly mixed, fosthiazate mixing is added portionwise, bleeding agent is added portionwise, is uniformly mixed, is cooled to room temperature, point Criticize and add remaining solvent, be well mixed, transparent oily liquids is finished product.
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| CN201710719305.1A CN107347908A (en) | 2017-08-21 | 2017-08-21 | A kind of compound Avermectins compound finish of ultra-low volume fosthiazate and preparation method |
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| CN201710719305.1A CN107347908A (en) | 2017-08-21 | 2017-08-21 | A kind of compound Avermectins compound finish of ultra-low volume fosthiazate and preparation method |
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