CN105340951A - Medicine composition for preventing and treating radopholus similis - Google Patents
Medicine composition for preventing and treating radopholus similis Download PDFInfo
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- CN105340951A CN105340951A CN201510931388.1A CN201510931388A CN105340951A CN 105340951 A CN105340951 A CN 105340951A CN 201510931388 A CN201510931388 A CN 201510931388A CN 105340951 A CN105340951 A CN 105340951A
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- carbosulfan
- fenbutatin oxide
- similes thorne
- radopholus similes
- treating
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Abstract
The invention belongs to the technical field of pesticide and in particular discloses a medicine composition for preventing and treating radopholus similis. The medicine comprises the following active compounds: carbosulfan and fenbutatin oxide with a mixing volume ratio of 5 to 8, 7 to 4 or 5 to 1. By mixing of a specific ratio, the toxicity effects of the carbosulfan and fenbutatin oxide to radopholus similis can achieve a synergistic interaction action, thus realizing the effect of effectively preventing and treating radopholus similis. In addition, by matching the two medicines for use, use concentration of the medicine can be reduced, cost is reduced and more importantly, harm to the plants is reduced.
Description
Technical field
The present invention relates to technical field of pesticide, specifically disclose a kind of pharmaceutical composition preventing and treating radopholus similes thorne.
Background technology
Radopholus similes thorne (
radopholussimilis) have another name called banana root rot, be the most dangerous obligatory parasitism nematode of banana, flower planting industry and a lot of economic crops, widely, the host plant reported has kind more than 350 to host range.This nematode, except serious harm banana, pepper and coconut, also endangers the ornamental plants such as the economic crops such as soybean, corn, jowar, sugarcane, eggplant, coffee, tomato and potato and the red palm, arrowroot, palm.The under ground portion of the host plants such as banana, pepper, coconut, betel nut, avocado, Xiao's Maranta and the soil sticked are the main paties of radopholus similes thorne long-distance communications.Because this eelworm harm is serious, therefore, have 55 countries to implement offical control to it, this nematode is also classified as the dangerous pest of the class plant quarantine forbidding entering a country by China.
The control of radopholus similes thorne comprises cultural control, biological control, physical control, chemical control etc., but chemical control is the important means of this nematode of control always.Because vegetables are to the particular/special requirement of chemical control, the chemical agent being applicable to radopholus similes thorne control is little, only have in non-stifling property nematode killing agent the low-residual such as carbosulfan, fenbutatin oxide medicament several.But how also rarely known by the people these two kinds of medicaments are to the complex role of radopholus similes thorne.
Summary of the invention
The present invention, in order to overcome in prior art the defect of the medicine lacking effectively control Meloidogyne incognita, provides a kind of pharmaceutical composition of high-efficiency prevention and control Meloidogyne incognita.
To achieve these goals, the present invention is achieved by the following technical programs:
Prevent and treat a pharmaceutical composition for radopholus similes thorne, comprise carbosulfan and fenbutatin oxide, the mixture volume ratio of described carbosulfan and the former medicine of fenbutatin oxide is 5:8,7:4 or 5:1.
The present invention found through experiments, carbosulfan and fenbutatin oxide have radopholus similes thorne separately certain murders effect, if but both are mixed according to specific ratio, the effect of Synergistic can be had, if but mix not in accordance with this special ratios, the effect of superposition can only be had effect.
Preferably, the mixture volume ratio of described carbosulfan and the former medicine of fenbutatin oxide is 5:1.The present invention studies discovery, and when the mixture volume ratio of carbosulfan and fenbutatin oxide is 5:1, both Synergistic results are the most remarkable.
Preferably, the weight percentage of described active ingredient is 10 ~ 50%.
More preferably, the weight percentage of described active ingredient is 20 ~ 30%.
Preferably, described combination dosage form comprises missible oil, microemulsion, aqueous emulsion, suspending agent, wetting powder and water dispersible granules.
Compared with prior art, the present invention has following beneficial effect:
Carbosulfan and fenbutatin oxide two kinds of medicines, by the mixing of special ratios, the virulence effect to radopholus similes thorne can be played the effect of Synergistic by the present invention, and from realizing the effect of high-efficiency prevention and control radopholus similes thorne.And, by two kinds of medicines with the use of, the working concentration of medicine can be reduced, not only can reduce costs, the more important thing is the harm that can reduce plant.
Embodiment
Further describe invention thinking of the present invention below in conjunction with specific embodiment, but embodiment does not limit in any form to protection scope of the present invention.Unless stated otherwise, the reagent adopted in embodiment, method and apparatus are the art conventional reagent, method and apparatus.
Unless stated otherwise, the feeds utilized raw material of following examples, reagent and material are commercial.
Radopholus similes thorne used in embodiment is from the seizure of rotten of banana, by for subsequent use after the carrot medium of the radopholus similes thorne of seizure in greenhouse breeds sufficient amount.The rearing conditions of radopholus similes thorne is: temperature 25 ~ 30 DEG C, relative moisture 40% ~ 70%, and suitable soil acidity-basicity ph 4 ~ 8, does not contact any chemical agent between feeding period.
Described carbosulfan and fenbutatin oxide are common commercially available prod.
embodiment 1
Prevent and treat a pharmaceutical composition for radopholus similes thorne, be made up of carbosulfan and fenbutatin oxide, the mixture volume ratio of described carbosulfan and fenbutatin oxide is 1:12; The concentration of carbosulfan is 92.8%, 80.3% former medicine during the concentration of fenbutatin oxide.
embodiment 2
Prevent and treat a pharmaceutical composition for radopholus similes thorne, be made up of carbosulfan and fenbutatin oxide, the mixture volume ratio of described carbosulfan and fenbutatin oxide is 1:6; The concentration of carbosulfan is 92.8%, 80.3% former medicine during the concentration of fenbutatin oxide.
embodiment 3
Prevent and treat a pharmaceutical composition for radopholus similes thorne, be made up of carbosulfan and fenbutatin oxide, the mixture volume ratio of described carbosulfan and fenbutatin oxide is 5:8; The concentration of carbosulfan is 92.8%, 80.3% former medicine during the concentration of fenbutatin oxide.
embodiment 4
Prevent and treat a pharmaceutical composition for radopholus similes thorne, be made up of carbosulfan and fenbutatin oxide, the mixture volume ratio of described carbosulfan and fenbutatin oxide is 7:4; The concentration of carbosulfan is 92.8%, 80.3% former medicine during the concentration of fenbutatin oxide.
embodiment 5
Prevent and treat a pharmaceutical composition for radopholus similes thorne, be made up of carbosulfan and fenbutatin oxide, the mixture volume ratio of described carbosulfan and fenbutatin oxide is 5:1; The concentration of carbosulfan is 92.8%, 80.3% former medicine during the concentration of fenbutatin oxide.
embodiment 6
Be used for the pharmaceutical composition of different proportion formula shown in embodiment 1 ~ 5 killing the test of radopholus similes thorne second instar larvae, experiment number of repetition twice, each concentration in triplicate, each repetition 30.
Drug use method:
Single dose: the mother liquor former medicine being configured to 10000ppm, dilutes it afterwards, and the concentration of carbosulfan is chosen as 500mg/L, 250mg/L, 125mg/L, 62.5mg/L and 15.625mg/L; The concentration of fenbutatin oxide is 200mg/L, 100mg/L, 50mg/L, 25mg/L and 12.5mg/L.
Mixture: the carbosulfan of selection: the proportioning of fenbutatin oxide is 1:12,1:6,5:8,7:4,5:1.Examination concentration gradient is supplied to be 16mg/L, 8mg/L, 4mg/L, 2mg/L, 1mg/L.
The nematode liquid of the liquid and 0.25ml of getting 0.25ml mixes in the raw drafting board be put into containing 24 holes, and each drug concentration process repeats 3 times.Respectively with 2.5% xylene solution and 2.5% acetone soln in contrast.
Data survey and statistical analysis: each test is all measure in medication and after processing 12 hours.Adopt needle point method, after medication process, use the individuality that dissecting needle acupuncture figure is stiff under the microscope, see that whether real it is dead, calculate dead borer population and supply the total borer population of examination.
Synergy calculates: according to LD
50calculate built agent and must survey toxicity index (ATI), theoretical toxicity index (TTI) and co-toxicity coefficient (CTC).If binary built agent is M, the single dose of composition M is A and B, and toxicity index is K, and percentage composition is P, take A as standard single dose.
Computing formula is as follows:
Toxicity index (TIA)=× 100=100 of A medicament
The toxicity index (TIB)=× 100 of B medicament
The actual toxicity index (ATI)=× 100 of M medicament
Theoretical toxicity index (TTI)=TIA × PA+TIB × PB of M medicament
Co-toxicity coefficient=× 100 of M medicament
Carbosulfan and the Toxicity Determination of fenbutatin oxide to radopholus similes thorne the results are shown in Table 1, and as can be seen from Table 1, after 12h effect, the lethal effect of carbosulfan to nematode is better than fosthiazate, wherein the LD of carbosulfan
50for 1.28ug/ml, the LD of fenbutatin oxide
50for 7.17ug/ml.In carbosulfan and fenbutatin oxide 5 kinds are composite, 3 kinds have certain synergistic effect, wherein best with the ratio synergistic effect of 5:1.Carbosulfan and the control of fenbutatin oxide to radopholus similes thorne have good effect, especially their the composite control efficiency that can better play radopholus similes thorne, co-toxicity coefficient can reach 144.67, apparently higher than each single dose, and has good synergistic effect.
Table 1 carbosulfan and fenbutatin oxide are to the Toxicity Determination result of radopholus similes thorne
.
Claims (5)
1. prevent and treat a pharmaceutical composition for radopholus similes thorne, it is characterized in that, comprise carbosulfan and fenbutatin oxide, the mixture volume ratio of described carbosulfan and the former medicine of fenbutatin oxide is 5:8,7:4 or 5:1.
2. the pharmaceutical composition of control radopholus similes thorne according to claim 1, is characterized in that, the mixture volume ratio of described carbosulfan and the former medicine of fenbutatin oxide is 5:1.
3. the pharmaceutical composition of control radopholus similes thorne according to claim 1 and 2, is characterized in that, the weight percentage of described active ingredient is 10 ~ 50%.
4. composition according to claim 3, is characterized in that, the weight percentage of described active ingredient is 20 ~ 30%.
5. composition according to claim 1 and 2, is characterized in that, described combination dosage form comprises missible oil, microemulsion, aqueous emulsion, suspending agent, wetting powder and water dispersible granules.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510931388.1A CN105340951A (en) | 2015-12-15 | 2015-12-15 | Medicine composition for preventing and treating radopholus similis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510931388.1A CN105340951A (en) | 2015-12-15 | 2015-12-15 | Medicine composition for preventing and treating radopholus similis |
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| Publication Number | Publication Date |
|---|---|
| CN105340951A true CN105340951A (en) | 2016-02-24 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510931388.1A Pending CN105340951A (en) | 2015-12-15 | 2015-12-15 | Medicine composition for preventing and treating radopholus similis |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1957708A (en) * | 2006-10-27 | 2007-05-09 | 陕西上格之路生物科学有限公司 | Pesticides composition of Avermectini and Fenbutatin Oxide |
| CN101180970A (en) * | 2007-12-03 | 2008-05-21 | 宋国春 | Hexaflumuron carbosulfan insecticidal composition |
| JP2009209124A (en) * | 2008-02-06 | 2009-09-17 | Nissan Chem Ind Ltd | Insect- or acarian-controlling composition |
-
2015
- 2015-12-15 CN CN201510931388.1A patent/CN105340951A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1957708A (en) * | 2006-10-27 | 2007-05-09 | 陕西上格之路生物科学有限公司 | Pesticides composition of Avermectini and Fenbutatin Oxide |
| CN101180970A (en) * | 2007-12-03 | 2008-05-21 | 宋国春 | Hexaflumuron carbosulfan insecticidal composition |
| JP2009209124A (en) * | 2008-02-06 | 2009-09-17 | Nissan Chem Ind Ltd | Insect- or acarian-controlling composition |
Non-Patent Citations (2)
| Title |
|---|
| ZHENGUO YANG ET AL.: "Joint Acaricidal Action of Diafenthiuron and Fenbutatin-oxide Against Tetranychus cinnabarinus(Boisudval)(Acari:Tetranychidae)", 《AGRICULTURAL SCIENCE & TECHNOLOGY》 * |
| 深圳诺普信农化股份有限公司: "《http://www.chinapesticide.gov.cn/hysj/index.jhtml》", 31 December 2006 * |
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