CN104474053A - Traditional Chinese veterinary medicine composition for treating porcine virus diarrhea, as well as preparation method and application of traditional Chinese veterinary medicine composition - Google Patents
Traditional Chinese veterinary medicine composition for treating porcine virus diarrhea, as well as preparation method and application of traditional Chinese veterinary medicine composition Download PDFInfo
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- 238000002360 preparation method Methods 0.000 title claims abstract description 32
- 239000003814 drug Substances 0.000 title claims abstract description 27
- 239000000203 mixture Substances 0.000 title claims abstract description 27
- 206010012735 Diarrhoea Diseases 0.000 title claims abstract description 19
- 241000700605 Viruses Species 0.000 title claims abstract description 13
- 241000282898 Sus scrofa Species 0.000 claims description 20
- 229940079593 drug Drugs 0.000 claims description 17
- 238000011282 treatment Methods 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 239000007788 liquid Substances 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 9
- 208000005577 Gastroenteritis Diseases 0.000 claims description 6
- 239000002671 adjuvant Substances 0.000 claims description 6
- 238000005516 engineering process Methods 0.000 claims description 6
- 241000411851 herbal medicine Species 0.000 claims description 5
- 230000000295 complement effect Effects 0.000 claims description 4
- 239000012530 fluid Substances 0.000 claims description 4
- 239000002994 raw material Substances 0.000 claims description 4
- 230000001954 sterilising effect Effects 0.000 claims description 4
- 239000008215 water for injection Substances 0.000 claims description 4
- 239000008187 granular material Substances 0.000 claims description 2
- 239000003960 organic solvent Substances 0.000 claims description 2
- 241000205585 Aquilegia canadensis Species 0.000 abstract 1
- 235000002991 Coptis groenlandica Nutrition 0.000 abstract 1
- 244000247747 Coptis groenlandica Species 0.000 abstract 1
- 241001648835 Polygonum cuspidatum Species 0.000 abstract 1
- 235000018167 Reynoutria japonica Nutrition 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000008092 positive effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 230000000694 effects Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 241000711484 Transmissible gastroenteritis virus Species 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 241001135549 Porcine epidemic diarrhea virus Species 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 238000002651 drug therapy Methods 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- 241000711573 Coronaviridae Species 0.000 description 1
- 208000005156 Dehydration Diseases 0.000 description 1
- 206010051511 Viral diarrhoea Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 208000028774 intestinal disease Diseases 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 208000037920 primary disease Diseases 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention provides a traditional Chinese veterinary medicine composition for treating porcine virus diarrhea, which is a preparation prepared from the following active ingredients in parts by weight: 30-100 parts of gallnut, 100-200 parts of coptis root hair, 150-300 parts of honeysuckle stem, 100-150 parts of fructus forsythiae and 150-250 parts of polygonum cuspidatum. The invention further provides a preparation method and an application of the traditional Chinese veterinary medicine composition. The medicine is used for treating or/and preventing the virus diarrhea, has a cure rate up to 89.2% after clinical use and has a positive effect on reducing economic loss of a farmer.
Description
Technical field
The present invention relates to a kind of Chinese veterinary medicinal composition for the treatment of pig virus diarrhoea.
Background technology
Porcine epizootic diarrhea (PED) is a kind of pig infectious intestinal disease caused by Porcine epidemic diarrhea virus (PEDV), and transmissible gastroenteritis of swine (TGE) is the communicable viral disease of a kind of high degree in contact caused by coronaviridae coronavirus genus transmissible gastro-enteritis virus (TGEV).Two viral diseases all main with vomiting, diarrhoea and dehydration for feature, the pig of each age group all can occur, sickness rate reaches as high as 100%, suckling pig is injured the most serious, porcine epizootic diarrhea is in early 1970s this disease of Britain's Late Cambrian, the state such as Belgian, Canadian, Japanese, German, French also occurs and reports the popular of PED subsequently, and just there is the report of this disease in China from early 1980s; Transmissible gastroenteritis of swine is since nineteen forty-six, this disease was broken out in U.S. swinery, also the distribution in the whole world at present, huge economic loss is caused to whole world pig industry, according to statistics, within 1977, France only breaks out due to what deal with TGE the expenses for prevention and control just consuming l000 ten thousand dollars, present many European countries close to 100% swinery or TGE is positive.Over the past two years, the popular of PED and TGE was on the rise, and also brought massive losses to the pig industry of China.Since second half 2010, In South China, East China, southwest and part province, North China occur that serious piglet diarrhea is popular, its cause of disease mostly is epidemic diarrhea virus and Transmissible gastroenteritis virus, the death of a large amount of suckling pig is caused to feed, after suckling pig within 10 ages in days infects, mortality rate nearly 100%, brings great economic loss to raiser.
Summary of the invention
Technical scheme of the present invention there is provided a kind of Chinese veterinary medicinal composition for the treatment of pig virus diarrhoea.Another technical scheme of the present invention there is provided preparation method and the purposes of this Chinese veterinary medicinal composition.
The invention provides a kind of Chinese veterinary medicinal composition for the treatment of pig virus diarrhoea, it is the preparation be prepared from by the crude drug of following weight proportioning:
Galla Chinensis 30-100 part, Rhizoma Coptidis root hair 100-200 part, Caulis Lonicerae 150-300 part, Fructus Forsythiae 100-150 part, Rhizoma Polygoni Cuspidati 150-250 part.
Further preferably, it is the preparation be prepared from by the crude drug of following weight proportioning:
Galla Chinensis 100 parts, Rhizoma Coptidis root hair 200 parts, Caulis Lonicerae 300 parts, Fructus Forsythiae 150 parts, Rhizoma Polygoni Cuspidati 250 parts.
Pharmaceutical composition of the present invention is active component by the protogenic medicinal powder of Galla Chinensis, Rhizoma Coptidis root hair, Caulis Lonicerae, Fructus Forsythiae, Rhizoma Polygoni Cuspidati, water or extractive with organic solvent, adds the preparation that the acceptable adjuvant of pharmacy or complementary composition are prepared from.
Wherein, described preparation is powder, oral liquid, granule.
Present invention also offers a kind of preparation method of Chinese veterinary medicinal composition, it comprises the steps:
A, take the raw material of each weight proportion;
B, directly beat powder, or decoct with water, adjust pH 6-7.5 after decoction liquor is concentrated; Add pharmaceutically acceptable adjuvant or complementary composition again and be prepared into pharmaceutically conventional preparation.
Wherein, described preparation is the preparation technology of oral liquid, described oral liquid: get raw material, adds the mass ratio 20-30 times water yield, decoct 2-3 time, each 1.5 hours, vacuum concentration to strength of fluid is 1.2g-1.5g crude drug in whole/mL, adjust ph is 6-7.5, adds water for injection subpackage, sterilizing.
Present invention also offers the purposes of this Chinese veterinary medicinal composition in the herbal medicine of preparation treatment pig virus diarrhoea.
Present invention also offers the purposes of described Chinese veterinary medicinal composition in the herbal medicine of preparation treatment transmissible gastroenteritis of swine.
Cause of disease due to pig virus diarrhoea is virus; therefore all antibiotics treatments are all without obvious effect; and vaccine protected effect is also poor; basic unprotect power after vaccinate; therefore the research controlling primary disease is concentrated on the Chinese herbal medicine of China by studies in China person; medicine of the present invention is used for the treatment of and preventing viral diarrhoea, and after Clinical practice, its cure rate is up to 89.2%, serves positive role to the economic loss reducing raiser.
Detailed description of the invention
The preparation technology of embodiment 1 powder of the present invention
Get Chinese crude drug Galla Chinensis 3kg, Rhizoma Coptidis root hair 10kg, Caulis Lonicerae 15kg, Fructus Forsythiae 10kg, Rhizoma Polygoni Cuspidati 15kg, pulverize, add adjuvant glucose to 100kg, subpackage after mix homogeneously, every bag of 1kg.
The preparation technology of embodiment 2 powder of the present invention
Get Chinese crude drug Galla Chinensis 5kg, Rhizoma Coptidis root hair 15kg, Caulis Lonicerae 20kg, Fructus Forsythiae 12kg, Rhizoma Polygoni Cuspidati 20kg, pulverize, add adjuvant glucose to 100kg, subpackage after mix homogeneously, every bag of 1kg.
The preparation technology of embodiment 3 powder of the present invention
Get Chinese crude drug Galla Chinensis 10kg, Rhizoma Coptidis root hair 20kg, Caulis Lonicerae 30kg, Fructus Forsythiae 15kg, Rhizoma Polygoni Cuspidati 25kg, pulverize, subpackage after mix homogeneously, every bag of 1kg.
The preparation of embodiment 4 oral liquid of the present invention
Get Chinese crude drug Galla Chinensis 3kg, Rhizoma Coptidis root hair 10kg, Caulis Lonicerae 15kg, Fructus Forsythiae 10kg, Rhizoma Polygoni Cuspidati 15kg, add the mass ratio 15-20 times water yield, decoct 2-3 time, each 1.5 hours, vacuum concentration to strength of fluid is 1.2g-1.5g crude drug in whole/mL, and adjust ph is 6-7.5, adds water for injection to 100 liter, subpackage, sterilizing.
The preparation of embodiment 5 oral liquid of the present invention
Get Chinese crude drug Galla Chinensis 5kg, Rhizoma Coptidis root hair 15kg, Caulis Lonicerae 20kg, Fructus Forsythiae 12kg, Rhizoma Polygoni Cuspidati 20kg, add the mass ratio 15-20 times water yield, decoct 2-3 time, each 1.5 hours, vacuum concentration to strength of fluid is 1.2g-1.5g crude drug in whole/mL, and adjust ph is 6-7.5, adds water for injection to 100 liter, subpackage, sterilizing.
The preparation of embodiment 6 oral liquid of the present invention
Get Chinese crude drug Galla Chinensis 10kg, Rhizoma Coptidis root hair 20kg, Caulis Lonicerae 30kg, Fructus Forsythiae 15kg, Rhizoma Polygoni Cuspidati 25kg, by the method preparation described in embodiment 4.
Beneficial effect of the present invention is proved below by way of concrete pharmacodynamics test.
The test of pesticide effectiveness of test example 1 Drug therapy porcine epizootic diarrhea of the present invention
1, materials and methods
The above example medicine that 1-6 produces of 1.1 test drug, is numbered A, B, C, D, E, F medicine respectively;
1.2 method
1.2.1 grouping is tested
Choose analyse according to clinical symptoms, pathology, affected pig epidemic diarrhea that the method such as pathogen separation is made a definite diagnosis, each 210 of transmissible gastroenteritis case piglet, often kind of disease test is divided into 7 groups, often organizes 30, sets up matched group.Test group adopts A, B, C, D, E, F medicine to treat respectively, and A, B, C drug treatment dosage is all by 1g/kg body weight, and D, E, F drug treatment dosage presses 1mL/kg body weight, and matched group does not adopt Drug therapy.
2 results
Result of the test shows, A, B, C, D, E, F medicine all has good therapeutic effect to porcine epizootic diarrhea and transmissible gastroenteritis, and clinical cure rate is up to more than 80%, and integrated cost and curative effect situation, C group and F group effect optimum, result of the test sees the following form.
Claims (8)
1. treat a Chinese veterinary medicinal composition for pig virus diarrhoea, it is characterized in that: it is the preparation be prepared from by the crude drug of following weight proportioning:
Galla Chinensis 30-100 part, Rhizoma Coptidis root hair 100-200 part, Caulis Lonicerae 150-300 part, Fructus Forsythiae 100-150 part, Rhizoma Polygoni Cuspidati 150-250 part.
2. Chinese veterinary medicinal composition according to claim 1, is characterized in that: it is the preparation be prepared from by the crude drug of following weight proportioning:
Galla Chinensis 100 parts, Rhizoma Coptidis root hair 200 parts, Caulis Lonicerae 300 parts, Fructus Forsythiae 150 parts, Rhizoma Polygoni Cuspidati 250 parts.
3. Chinese veterinary medicinal composition according to claim 1 and 2, it is characterized in that: it is active component by the protogenic medicinal powder of Galla Chinensis, Rhizoma Coptidis root hair, Caulis Lonicerae, Fructus Forsythiae, Rhizoma Polygoni Cuspidati, water or extractive with organic solvent, add the preparation that the acceptable adjuvant of pharmacy or complementary composition are prepared from.
4. Chinese veterinary medicinal composition according to claim 3, is characterized in that: described preparation is powder, oral liquid, granule.
5. the preparation method of the Chinese veterinary medicinal composition described in claim 1-4 any one, it comprises the steps:
A, take the raw material of each weight proportion;
B, directly beat powder, or decoct with water, adjust pH 6-7.5 after decoction liquor is concentrated; Add pharmaceutically acceptable adjuvant or complementary composition again and be prepared into pharmaceutically conventional preparation.
6. the preparation method of Chinese veterinary medicinal composition according to claim 5, it is characterized in that: described preparation is oral liquid, the preparation technology of described oral liquid: get raw material, add the mass ratio 20-30 times water yield, decoct 2-3 time, each 1.5 hours, vacuum concentration to strength of fluid is 1.2g-1.5g crude drug in whole/mL, adjust ph is 6-7.5, adds water for injection subpackage, sterilizing.
7. the purposes of the Chinese veterinary medicinal composition described in claim 1-4 any one in the herbal medicine of preparation treatment pig virus diarrhoea.
8. the purposes of the Chinese veterinary medicinal composition described in claim 1-4 any one in the herbal medicine of preparation treatment transmissible gastroenteritis of swine.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104857501A (en) * | 2015-06-08 | 2015-08-26 | 信阳农林学院 | Chinese and western medicine composition for treating piglet diarrhea and preparation method thereof |
| CN104855684A (en) * | 2015-04-13 | 2015-08-26 | 成都乾坤动物药业有限公司 | An antibacterial traditional Chinese medicine microbial fermentation preparation and a preparation method and application thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107233454B (en) * | 2017-08-07 | 2021-01-26 | 阿坝藏族羌族自治州畜牧科学技术研究所 | Traditional Chinese medicine and Tibetan medicine composition for preventing and treating livestock diarrhea |
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| KR20090094618A (en) * | 2008-03-03 | 2009-09-08 | 김충정 | Compositions for preventing or treating bacterial infections or inflammatory disease |
| CN103263493A (en) * | 2013-04-16 | 2013-08-28 | 阚兆云 | Traditional Chinese medicine composition and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104855684A (en) * | 2015-04-13 | 2015-08-26 | 成都乾坤动物药业有限公司 | An antibacterial traditional Chinese medicine microbial fermentation preparation and a preparation method and application thereof |
| CN104855684B (en) * | 2015-04-13 | 2018-05-01 | 成都乾坤动物药业有限公司 | A kind of antibacterial Chinese medicine microbial fermentation preparation and its preparation method and application |
| CN104857501A (en) * | 2015-06-08 | 2015-08-26 | 信阳农林学院 | Chinese and western medicine composition for treating piglet diarrhea and preparation method thereof |
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