CN104474053A - Traditional Chinese veterinary medicine composition for treating porcine virus diarrhea, as well as preparation method and application of traditional Chinese veterinary medicine composition - Google Patents
Traditional Chinese veterinary medicine composition for treating porcine virus diarrhea, as well as preparation method and application of traditional Chinese veterinary medicine composition Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention provides a traditional Chinese veterinary medicine composition for treating porcine virus diarrhea, which is a preparation prepared from the following active ingredients in parts by weight: 30-100 parts of gallnut, 100-200 parts of coptis root hair, 150-300 parts of honeysuckle stem, 100-150 parts of fructus forsythiae and 150-250 parts of polygonum cuspidatum. The invention further provides a preparation method and an application of the traditional Chinese veterinary medicine composition. The medicine is used for treating or/and preventing the virus diarrhea, has a cure rate up to 89.2% after clinical use and has a positive effect on reducing economic loss of a farmer.
Description
Technical field
The present invention relates to a kind of Chinese veterinary medicinal composition for the treatment of pig virus diarrhoea.
Background technology
Porcine epizootic diarrhea (PED) is a kind of pig infectious intestinal disease caused by Porcine epidemic diarrhea virus (PEDV), and transmissible gastroenteritis of swine (TGE) is the communicable viral disease of a kind of high degree in contact caused by coronaviridae coronavirus genus transmissible gastro-enteritis virus (TGEV).Two viral diseases all main with vomiting, diarrhoea and dehydration for feature, the pig of each age group all can occur, sickness rate reaches as high as 100%, suckling pig is injured the most serious, porcine epizootic diarrhea is in early 1970s this disease of Britain's Late Cambrian, the state such as Belgian, Canadian, Japanese, German, French also occurs and reports the popular of PED subsequently, and just there is the report of this disease in China from early 1980s; Transmissible gastroenteritis of swine is since nineteen forty-six, this disease was broken out in U.S. swinery, also the distribution in the whole world at present, huge economic loss is caused to whole world pig industry, according to statistics, within 1977, France only breaks out due to what deal with TGE the expenses for prevention and control just consuming l000 ten thousand dollars, present many European countries close to 100% swinery or TGE is positive.Over the past two years, the popular of PED and TGE was on the rise, and also brought massive losses to the pig industry of China.Since second half 2010, In South China, East China, southwest and part province, North China occur that serious piglet diarrhea is popular, its cause of disease mostly is epidemic diarrhea virus and Transmissible gastroenteritis virus, the death of a large amount of suckling pig is caused to feed, after suckling pig within 10 ages in days infects, mortality rate nearly 100%, brings great economic loss to raiser.
Summary of the invention
Technical scheme of the present invention there is provided a kind of Chinese veterinary medicinal composition for the treatment of pig virus diarrhoea.Another technical scheme of the present invention there is provided preparation method and the purposes of this Chinese veterinary medicinal composition.
The invention provides a kind of Chinese veterinary medicinal composition for the treatment of pig virus diarrhoea, it is the preparation be prepared from by the crude drug of following weight proportioning:
Galla Chinensis 30-100 part, Rhizoma Coptidis root hair 100-200 part, Caulis Lonicerae 150-300 part, Fructus Forsythiae 100-150 part, Rhizoma Polygoni Cuspidati 150-250 part.
Further preferably, it is the preparation be prepared from by the crude drug of following weight proportioning:
Galla Chinensis 100 parts, Rhizoma Coptidis root hair 200 parts, Caulis Lonicerae 300 parts, Fructus Forsythiae 150 parts, Rhizoma Polygoni Cuspidati 250 parts.
Pharmaceutical composition of the present invention is active component by the protogenic medicinal powder of Galla Chinensis, Rhizoma Coptidis root hair, Caulis Lonicerae, Fructus Forsythiae, Rhizoma Polygoni Cuspidati, water or extractive with organic solvent, adds the preparation that the acceptable adjuvant of pharmacy or complementary composition are prepared from.
Wherein, described preparation is powder, oral liquid, granule.
Present invention also offers a kind of preparation method of Chinese veterinary medicinal composition, it comprises the steps:
A, take the raw material of each weight proportion;
B, directly beat powder, or decoct with water, adjust pH 6-7.5 after decoction liquor is concentrated; Add pharmaceutically acceptable adjuvant or complementary composition again and be prepared into pharmaceutically conventional preparation.
Wherein, described preparation is the preparation technology of oral liquid, described oral liquid: get raw material, adds the mass ratio 20-30 times water yield, decoct 2-3 time, each 1.5 hours, vacuum concentration to strength of fluid is 1.2g-1.5g crude drug in whole/mL, adjust ph is 6-7.5, adds water for injection subpackage, sterilizing.
Present invention also offers the purposes of this Chinese veterinary medicinal composition in the herbal medicine of preparation treatment pig virus diarrhoea.
Present invention also offers the purposes of described Chinese veterinary medicinal composition in the herbal medicine of preparation treatment transmissible gastroenteritis of swine.
Cause of disease due to pig virus diarrhoea is virus; therefore all antibiotics treatments are all without obvious effect; and vaccine protected effect is also poor; basic unprotect power after vaccinate; therefore the research controlling primary disease is concentrated on the Chinese herbal medicine of China by studies in China person; medicine of the present invention is used for the treatment of and preventing viral diarrhoea, and after Clinical practice, its cure rate is up to 89.2%, serves positive role to the economic loss reducing raiser.
Detailed description of the invention
The preparation technology of embodiment 1 powder of the present invention
Get Chinese crude drug Galla Chinensis 3kg, Rhizoma Coptidis root hair 10kg, Caulis Lonicerae 15kg, Fructus Forsythiae 10kg, Rhizoma Polygoni Cuspidati 15kg, pulverize, add adjuvant glucose to 100kg, subpackage after mix homogeneously, every bag of 1kg.
The preparation technology of embodiment 2 powder of the present invention
Get Chinese crude drug Galla Chinensis 5kg, Rhizoma Coptidis root hair 15kg, Caulis Lonicerae 20kg, Fructus Forsythiae 12kg, Rhizoma Polygoni Cuspidati 20kg, pulverize, add adjuvant glucose to 100kg, subpackage after mix homogeneously, every bag of 1kg.
The preparation technology of embodiment 3 powder of the present invention
Get Chinese crude drug Galla Chinensis 10kg, Rhizoma Coptidis root hair 20kg, Caulis Lonicerae 30kg, Fructus Forsythiae 15kg, Rhizoma Polygoni Cuspidati 25kg, pulverize, subpackage after mix homogeneously, every bag of 1kg.
The preparation of embodiment 4 oral liquid of the present invention
Get Chinese crude drug Galla Chinensis 3kg, Rhizoma Coptidis root hair 10kg, Caulis Lonicerae 15kg, Fructus Forsythiae 10kg, Rhizoma Polygoni Cuspidati 15kg, add the mass ratio 15-20 times water yield, decoct 2-3 time, each 1.5 hours, vacuum concentration to strength of fluid is 1.2g-1.5g crude drug in whole/mL, and adjust ph is 6-7.5, adds water for injection to 100 liter, subpackage, sterilizing.
The preparation of embodiment 5 oral liquid of the present invention
Get Chinese crude drug Galla Chinensis 5kg, Rhizoma Coptidis root hair 15kg, Caulis Lonicerae 20kg, Fructus Forsythiae 12kg, Rhizoma Polygoni Cuspidati 20kg, add the mass ratio 15-20 times water yield, decoct 2-3 time, each 1.5 hours, vacuum concentration to strength of fluid is 1.2g-1.5g crude drug in whole/mL, and adjust ph is 6-7.5, adds water for injection to 100 liter, subpackage, sterilizing.
The preparation of embodiment 6 oral liquid of the present invention
Get Chinese crude drug Galla Chinensis 10kg, Rhizoma Coptidis root hair 20kg, Caulis Lonicerae 30kg, Fructus Forsythiae 15kg, Rhizoma Polygoni Cuspidati 25kg, by the method preparation described in embodiment 4.
Beneficial effect of the present invention is proved below by way of concrete pharmacodynamics test.
The test of pesticide effectiveness of test example 1 Drug therapy porcine epizootic diarrhea of the present invention
1, materials and methods
The above example medicine that 1-6 produces of 1.1 test drug, is numbered A, B, C, D, E, F medicine respectively;
1.2 method
1.2.1 grouping is tested
Choose analyse according to clinical symptoms, pathology, affected pig epidemic diarrhea that the method such as pathogen separation is made a definite diagnosis, each 210 of transmissible gastroenteritis case piglet, often kind of disease test is divided into 7 groups, often organizes 30, sets up matched group.Test group adopts A, B, C, D, E, F medicine to treat respectively, and A, B, C drug treatment dosage is all by 1g/kg body weight, and D, E, F drug treatment dosage presses 1mL/kg body weight, and matched group does not adopt Drug therapy.
2 results
Result of the test shows, A, B, C, D, E, F medicine all has good therapeutic effect to porcine epizootic diarrhea and transmissible gastroenteritis, and clinical cure rate is up to more than 80%, and integrated cost and curative effect situation, C group and F group effect optimum, result of the test sees the following form.
Claims (8)
1. treat a Chinese veterinary medicinal composition for pig virus diarrhoea, it is characterized in that: it is the preparation be prepared from by the crude drug of following weight proportioning:
Galla Chinensis 30-100 part, Rhizoma Coptidis root hair 100-200 part, Caulis Lonicerae 150-300 part, Fructus Forsythiae 100-150 part, Rhizoma Polygoni Cuspidati 150-250 part.
2. Chinese veterinary medicinal composition according to claim 1, is characterized in that: it is the preparation be prepared from by the crude drug of following weight proportioning:
Galla Chinensis 100 parts, Rhizoma Coptidis root hair 200 parts, Caulis Lonicerae 300 parts, Fructus Forsythiae 150 parts, Rhizoma Polygoni Cuspidati 250 parts.
3. Chinese veterinary medicinal composition according to claim 1 and 2, it is characterized in that: it is active component by the protogenic medicinal powder of Galla Chinensis, Rhizoma Coptidis root hair, Caulis Lonicerae, Fructus Forsythiae, Rhizoma Polygoni Cuspidati, water or extractive with organic solvent, add the preparation that the acceptable adjuvant of pharmacy or complementary composition are prepared from.
4. Chinese veterinary medicinal composition according to claim 3, is characterized in that: described preparation is powder, oral liquid, granule.
5. the preparation method of the Chinese veterinary medicinal composition described in claim 1-4 any one, it comprises the steps:
A, take the raw material of each weight proportion;
B, directly beat powder, or decoct with water, adjust pH 6-7.5 after decoction liquor is concentrated; Add pharmaceutically acceptable adjuvant or complementary composition again and be prepared into pharmaceutically conventional preparation.
6. the preparation method of Chinese veterinary medicinal composition according to claim 5, it is characterized in that: described preparation is oral liquid, the preparation technology of described oral liquid: get raw material, add the mass ratio 20-30 times water yield, decoct 2-3 time, each 1.5 hours, vacuum concentration to strength of fluid is 1.2g-1.5g crude drug in whole/mL, adjust ph is 6-7.5, adds water for injection subpackage, sterilizing.
7. the purposes of the Chinese veterinary medicinal composition described in claim 1-4 any one in the herbal medicine of preparation treatment pig virus diarrhoea.
8. the purposes of the Chinese veterinary medicinal composition described in claim 1-4 any one in the herbal medicine of preparation treatment transmissible gastroenteritis of swine.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104857501A (en) * | 2015-06-08 | 2015-08-26 | 信阳农林学院 | Chinese and western medicine composition for treating piglet diarrhea and preparation method thereof |
| CN104855684A (en) * | 2015-04-13 | 2015-08-26 | 成都乾坤动物药业有限公司 | An antibacterial traditional Chinese medicine microbial fermentation preparation and a preparation method and application thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107233454B (en) * | 2017-08-07 | 2021-01-26 | 阿坝藏族羌族自治州畜牧科学技术研究所 | Traditional Chinese medicine and Tibetan medicine composition for preventing and treating livestock diarrhea |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104855684A (en) * | 2015-04-13 | 2015-08-26 | 成都乾坤动物药业有限公司 | An antibacterial traditional Chinese medicine microbial fermentation preparation and a preparation method and application thereof |
| CN104855684B (en) * | 2015-04-13 | 2018-05-01 | 成都乾坤动物药业有限公司 | A kind of antibacterial Chinese medicine microbial fermentation preparation and its preparation method and application |
| CN104857501A (en) * | 2015-06-08 | 2015-08-26 | 信阳农林学院 | Chinese and western medicine composition for treating piglet diarrhea and preparation method thereof |
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Address after: No. 259, Middle Section of Jinfu Road, Wenjiang District, Chengdu City, Sichuan Province, 611130 Patentee after: CHENGDU QIANKUN VETERINARY PHARMACEUTICAL CO.,LTD. Address before: 611130 no.259 Jinfu Road, Chengdu cross strait science and Technology Industrial Development Park, Wenjiang District, Chengdu City, Sichuan Province Patentee before: CHENGDU QIANKUN VETERINARY PHARMACEUTICAL Co.,Ltd. |
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