CN1044401A - The process for purification of vitacoenzyme tablet and Wei-Mei-Su agent - Google Patents
The process for purification of vitacoenzyme tablet and Wei-Mei-Su agent Download PDFInfo
- Publication number
- CN1044401A CN1044401A CN 89106948 CN89106948A CN1044401A CN 1044401 A CN1044401 A CN 1044401A CN 89106948 CN89106948 CN 89106948 CN 89106948 A CN89106948 A CN 89106948A CN 1044401 A CN1044401 A CN 1044401A
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- Prior art keywords
- vitacoenzyme
- finished product
- highly finished
- tablet
- soaks
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The preparation method of a kind of medicine sheet, agent is specially adapted to medicine refining.
Vitacoenzyme goods active constituent content is low at present, and patient's taking dose is big, is difficult to adapt to.The present invention adopts and will have now in the distilled water that vitacoenzyme is dissolved in 10 times, soaks 20 minutes, and temperature is 50-60 ℃ of filtration then.Filtering residue is soaked again, filter 3-5 time like this, each time filtrate is mixed the back and is concentrated in vacuum kettle, makes powder with spray drying method at last and promptly gets highly finished product, this refining vitacoenzyme effective ingredient height, easily packing, transportation.
Description
The preparation method of a kind of medicine sheet, agent is specially adapted to medicine refining.
For a long time, be used for the vitacoenzyme that medicine film-making and capsule are used, still Bao Han has a large amount of invalid element-bean dregs except that active ingredient.In medical applications, it is excessive that the patient feels taking dose deeply, is difficult to adapt to, and prepares, store, transport all sense inconvenience.A host of facts show vitacoenzyme refiningly has a very necessity.
Purpose of the present invention just reduces the invalid element in the vitacoenzyme as far as possible, thereby the taking dose that reduces the patient is convenient to again store and transportation.
Through preliminary test, the active ingredient in the vitacoenzyme, great majority are water miscible.These compositions are through 50～60 ℃ hot water extraction 5～6 times, most of all can be molten substantially all be bean dregs in the residual insoluble matter in the aqueous solution.The aqueous solution that is extracted is compressed, and spray drying shows by analysis refining powder, contains whole active ingredients of vitacoenzyme.
Vitacoenzyme is to be culture medium with the cadmium yellow bean dregs, a kind of combination product that makes behind the false capsule culture propagation of inoculation Yi Limeng bacterium.Contain multivitamin, aminoacid, trace element, multiple proteins, saccharide and fat etc. through chemical analysis.
When producing the vitacoenzyme elaboration, it is an amount of to get former vitacoenzyme, and the distilled water that adds 10 times of amounts soaked 20 minutes under 50～60 ℃ of conditions, and the cloth bag of packing into then carries out coarse filtration to be separated.The distilled water diluting that filtering residue is added again 6 times of amounts soaks method extraction like this 3～5 times.Each time extract merges, and with 6～8 layers of husky cloth wrapping, is squeezed to and does or centrifuge dripping.Filtrate is put into vacuum kettle under 650mmHg vacuum and 60 ℃ of conditions, concentrate, make the concentrated solution relative density be about 1.1 hours, make powder promptly with spray drying method.
The refining powder of vitacoenzyme is added starch be mixed, it is an amount of to add 70% ethanol, makes soft material, and sugaring in 50～60 ℃ of dryings, adds magnesium stearate, Pulvis Talci mixing tabletting, sugar coating get final product refining vitacoenzyme coated tablet.
Vitacoenzyme tablet, highly finished product such as agent, oral liquid have effective effect content height, and taking dose is few, are convenient to characteristics such as packing, transportation, the simple cost of method for production be low.
Claims (5)
1, the highly finished product of vitacoenzyme tablet and vitacoenzyme tablet are to be culture medium with the cadmium yellow bean dregs, make true a kind of complex behind the false capsule culture propagation of inoculation Yi Limeng bacterium, and its feature exists: vitacoenzyme adding distil water that will be an amount of soaks, and reinstalls cloth bag coarse filtration separation; Filtering residue adding distil water more so extracts 3～5 times, and each time extracting solution is merged, and with husky cloth wrapping, is squeezed to and does or centrifuge dripping, and filtrate is put into vacuum kettle and concentrated, and makes powder with spray drying method then.
2, vitacoenzyme highly finished product as claimed in claim 1 is characterized in that: when thick vitacoenzyme is added distillation and soaks, add 10～6 times of distilled water, temperature was 50～60 ℃ of scope soak times 20 minutes.
3, vitacoenzyme highly finished product as claimed in claim 1 is characterized in that: Sha Bubao will be with 6～8 layers.
4, vitacoenzyme highly finished product as claimed in claim 1, it is characterized in that: the vacuum in the vacuum kettle adds 650mmHg, and temperature is 60 ℃.
5, vitacoenzyme highly finished product as claimed in claim 1 is characterized in that: the concentrated solution in the vacuum kettle is promptly sprayable about 1.1 hours of relative density.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 89106948 CN1044401A (en) | 1989-09-11 | 1989-09-11 | The process for purification of vitacoenzyme tablet and Wei-Mei-Su agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 89106948 CN1044401A (en) | 1989-09-11 | 1989-09-11 | The process for purification of vitacoenzyme tablet and Wei-Mei-Su agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1044401A true CN1044401A (en) | 1990-08-08 |
Family
ID=4856993
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 89106948 Pending CN1044401A (en) | 1989-09-11 | 1989-09-11 | The process for purification of vitacoenzyme tablet and Wei-Mei-Su agent |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1044401A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100457916C (en) * | 2006-07-14 | 2009-02-04 | 唐品志 | Solid fermenting method for vitacoenzyme medicine |
| CN106265863A (en) * | 2016-08-30 | 2017-01-04 | 山东百维药业有限公司 | A kind of vitacoenzyme compositions, hard capsule comprising said composition and preparation method thereof |
-
1989
- 1989-09-11 CN CN 89106948 patent/CN1044401A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100457916C (en) * | 2006-07-14 | 2009-02-04 | 唐品志 | Solid fermenting method for vitacoenzyme medicine |
| CN106265863A (en) * | 2016-08-30 | 2017-01-04 | 山东百维药业有限公司 | A kind of vitacoenzyme compositions, hard capsule comprising said composition and preparation method thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |