CN104436154B - There is compositions and the preparation method reducing liver tg content effect - Google Patents
There is compositions and the preparation method reducing liver tg content effect Download PDFInfo
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Abstract
The present invention relates to a kind of to reduce the compositions of content of triglyceride, its preparation method in liver, further relate to the application in Food and hygienical food or medicine of this compositions.The compositions with reduction liver tg content effect of the present invention consists of the following composition: Rhizoma Imperatae 15 40 parts, Radix Puerariae 40 60 parts, 15 40 parts of Fructus Mori, Fructus Mume 5 15 parts, tea 18 parts, maize oligopeptide 50 110 parts.The technology point of the present invention is to utilize tradition to have being used in combination of be used as medicine kind and new resource food raw material being eaten for a long time history, action character according to each material, collocation uses, and utilizes Experiment of Zoology to carry out combining form and ratio that screening active ingredients finds to have the effect of significantly reducing to content of triglyceride in liver weight and liver.
Description
Technical field
The present invention relates to a kind of to reduce the compositions of content of triglyceride, its preparation method in liver, also relate to
And the application that this compositions is in Food and hygienical food or medicine.
Technical background
Liver is the interior organ based on metabolic function of health, and plays deoxidation, storage inside health
Glycogen, the effect of synthesis etc. of secreted protein.The fat content of normal liver is the lowest, because liver energy
By fat and phosphoric acid and choline binding, it is transformed into phospholipid, is transported to other positions internal.When liver function such as weakens,
Liver converting fat be phospholipid ability also with and weaken, fat can not shift, and just in liver inner accumulated, becomes
" fatty liver ".When fat generation is too much, more likely develop into liver cirrhosis, produce series of symptoms.Excessively oil
Greasy diet, indulge in excessive drinking, the bad living habit such as stay up late causes digesting and assimilating physiological function imbalance and will also result in fat
Fat is hoarded in liver.
Although finding that fatty liver exists with hyperlipemia clinically to associate, but correlational study showing, high triglyceride
Increasing the prevalence of fatty liver, hypercholesterolemia does not has much impacts to the ill of fatty liver.Studies have found that, high
The fatty liver prevalence rate 29.32% in blood fat disease, hence it is evident that higher than the 12.85% of normal lipid, has height statistics
Meaning (P ＜ 0.01), simple triglyceride mass formed by blood stasis and high triglyceride hypercholesterolemia group Fatty Liver Diseases
Rate is respectively 32.93% and 39.02%.The prophylactico-therapeutic measures of fatty liver must control body weight, prevents obesity, changes
Dietary structure, controls the Excess free enthalpy of high fat diet, strengthens physical training.Hyperlipidemia and fatty liver are entirely
Two concepts, two kinds of diseases.Controlling blood lipid level and contribute to reducing the incidence rate of fatty liver, hyperlipidemia can be led
Cause or promote the generation of fatty liver, and the blood fat of partial fat hepatopath is the highest.Fatty liver with hyperlipidemia
Patient can not rashly apply hypolipidemic.On the one hand, most of blood lipid-lowering medicines have liver toxicity, can draw
Play jaundice or drug induced hepatic injury, even result in liver cirrhosis and liver failure；On the other hand, blood lipid-lowering medicine
There is " driving fat " effect, the lipid in blood " can be driven " liver, make fatty liver more serious.Greatly
Multi-experts are thought, treatment fatty liver is in principle without hypolipidemic, if blood lipid level is higher, and can be comprehensively
On the basis for the treatment of, suitably give hypolipidemic, and tightly monitor the change of liver function, drug withdrawal if desired.Fat
The treatment of liver may select antioxidant and Rhizoma Alismatis, Radix Salviae Miltiorrhizae, the Fructus Persicae such as polyenoid phospholipid elder generation phatidylcholine, vitamin E
The Chinese medicinal formulaes such as core, Cordyceps mycelium, the Radix Rehmanniae, Fructus Crataegi, Folium Nelumbinis, Artemisia anethoicles Mattf, the Radix Polygoni Multiflori, Cortex Moutan.But medicine
Having many untoward reaction unavoidably, the untoward reaction of some Chinese medicine is more indefinite.Exploitation is the most safe and reliable again can
The food reducing liver tg level of long-term taking or health food are technical problems urgently to be resolved hurrily.
Summary of the invention
The purpose of the present invention aims to provide and a kind of can reduce the compositions of content of triglyceride in liver.
Another object of the present invention is to provide the preparation method of this compositions.
It is still another object of the present invention to provide the application of this compositions.
The compositions with reduction liver tg content effect of the present invention consists of the following composition: white
Rhizoma Imperatae 15-40 part, Radix Puerariae 40-60 part, Fructus Mori 15-40 part, Fructus Mume 5-15 part, tea 1-8 part, Semen Maydis
Oligopeptide 50-110 part.
Present composition formula can be optimized for Rhizoma Imperatae 20-25 part, Radix Puerariae 40-45 part, Fructus Mori 20-25
Part, Fructus Mume 6-10 part, tea 1-5 part, maize oligopeptide 70-85 part.
It is one or more in black tea, green tea, oolong tea, Folium camelliae assamicae that above-mentioned tea can be selected from.
Of the present invention have the preparation method of the compositions reducing liver tg content effect by following
Step forms:
One, extract: take Rhizoma Imperatae, Radix Puerariae, Fructus Mori, Fructus Mume, tea component mixing, add 8-15 times of weight,
Volumetric concentration is the ethanol water of 0-30%, and 70-100 DEG C is extracted 0.5-1 hour, extract 1-2 time, take
Extracting solution；
Two, concentrate: extracting solution is centrifuged through 5000-10000r/min, filters through ultrafilter membrane, and filtrate exists
The concentrated solution that solid content is 10-20% is made after concentrating at a temperature of 50-80 DEG C；
Three, mixing: take maize oligopeptide and be dissolved in concentrated solution, mix homogeneously, make combination extracting solution.
The preparation method of the present composition uses one or both in the aqueous solvent or ethanol that polarity is bigger, when
When volumetric concentration is 0%, it is aqueous solution, it is possible to extract the most of polysaccharide in medical material, saponins, Huang
The compositions such as ketone, the relatively fewer following process that is prone to of alcohol consumption processes.Major part is planted after centrifugal by extracting solution
Fabric texture impurity and insoluble substance separate；Obtain the extracting solution of effective ingredient, then surpass through ultrafiltration apparatus
Filter, removes the macromolecule compositions such as the pectin without functional activity of the present invention, starch, protein, and tiny
Solid float, remains the active component in extracting solution such as flavone, saponin, organic acid, Polyphenols, to carrying
Take liquid to carry out purifying and purification process；Filtered extracting solution can be through conventional concentrating under reduced pressure or employing membrance concentration
Remove portion of water, obtain concentrated solution；Maize oligopeptide is dissolved in concentrated solution, obtains combining extracting solution,
Combination extracting solution can pack easily stored transport after sterilizing, can be used for direct dispensing fluid series products.
Of the present invention have the compositions reducing liver tg content effect answering in preparing food
With.
Of the present invention have the compositions of reduction liver tg content effect in preparing health food
Application.
Of the present invention have the compositions reducing liver tg content effect answering in preparing medicine
With.
According to a conventional method described combination extracting solution is directly allocated the food making drink form；Or concentrate
Or make after drying instant powder, granule, effervescent tablet, buccal tablet, the food of teabag form or health food or
Medicine.
Compositions integration of edible and medicinal herbs part of the present invention selects Rhizoma Imperatae, Radix Puerariae, Fructus Mori, Fructus Mume, tea, its
Middle Rhizoma Imperatae clearing away heat-damp and promoting diuresis can solve excessive thirst, Radix Puerariae alcoholic intoxication joins Fructus Mori, the effect moisturized is promoted the production of body fluid in Fructus Mume increase, with
Tea mediation polyphenols the most therein can play the effect of antioxidation free radical resisting.Collocation new resource food
Maize oligopeptide is mainly by its antioxygenic property, and then the liver protecting.This compositions formula composition with in
Based on doctor's Chinese medicine determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, new resource food monomer component of arranging in pairs or groups, degree to fatty liver while protecting the liver
Have and certain alleviate effect, reach the effect of Synergistic.
This compositions is eaten for a long time or will not bring untoward reaction and side effect for tea-drinking.
Compositions of the present invention uses new resource food material to carry out compatibility with the Chinese medicine of integration of edible and medicinal herbs,
Give full play to effect of each component.Can make liquid beverage, oral liquid, granule, soft capsule, hard capsule,
Tablet.As required the medical material part (Rhizoma Imperatae, Radix Puerariae, Fructus Mori, Fructus Mume and tea) in compositions can be entered
Row makes extracting solution or extractum after extracting, then be formulated directly into after being proportionally added into maize oligopeptide liquid beverage or
Oral liquid；Or material part of getting it filled adds the adjuvants such as suitable excipient after adding maize oligopeptide after crushed again
Make granule or capsule or tablet.Food can also be added join according to food or the processing request of health food
Material or additive are made has prevention alcoholic fatty liver or alcoholic hepatitis or alcoholic fibrosis or ethanol
The food of property liver cirrhosis effect or health food or medicine.
Rhizoma Imperatae described in the present composition is grass Herba Imperatae (Imperata cylindrical
Beauv.var.major (Nees) C.E.Hubb.) dry rhizome, excavate in season in spring and autumn two, clean, dry,
Remove fibrous root and film quality sheath is made.Described Radix Puerariae is legume pueraria lobata (Pueraria lobata
(Wild.) Ohwi) dry root, excavate in season autumn and winter two, remove impurity, clean, run through, take advantage of fresh-cut become
Sheet or fritter, be dried and make.Described Fructus Mori is the dried fruit of moraceae plants Mulberry (Morus alba L.)
Fringe, gathers after fruit reddens maturation, dries and make after drying or slightly steaming.Described Fructus Mume is rosaceous plant
The dry almost ripe fruit of prunus mume (sieb.) sieb.et zucc. (Prunusmume. (Sieb.) Sieb.etZucc.), summer, fruit was the most ripe
Shi Caishou is vexed black to complexion changed after oven drying at low temperature.Described Folium Camelliae sinensis is with Camellia sinensis Camellia sinensis L.
The bud of O.Kunts, leaf, tender stem are raw material, through green tea or black tea or oolong tea or Folium camelliae assamicae processing technique system
The dry Folium Camelliae sinensis become.Described maize oligopeptide is with zein as raw material, through sizing mixing, protease hydrolyzed,
Separate, filter, relative molecular weight that the technique such as spray drying produces less than 1000, oligopeptide percentage contains
The powdered rubber being mainly composed of peptide that amount is more than 75%, protein content is more than 80%.
The compositions of the present invention, recipe determination is based on combining tcm prescription application and clinical pharmacology.Mesh
Before show about the Radix Puerariae activity research in compositions: the puerarin in Radix Puerariae, daiazi, daidzein, dye
The material wood osajin composition such as glycosides is respectively provided with and resists myocardial ischemia, expands the cardiovascular system pharmacology such as blood vessel, blood fat reducing and live
Property.Wherein, puerarin can substantially reduce the content of mice serum T-CHOL, containing of high density lipoprotein increasing
Amount, reduces low density lipoprotein, LDL and very low density lipoprotein (VLDL) content, prevents low density lipoprotein, LDL over oxidation.Pueraria lobota
The research of root is mainly for the cholesterol composition in blood fat.For lipid in Folium Camelliae sinensis regulation liver and fatty tissue
The focus of metabolism research is concentrated mainly on fatty acid synthesis and fatty acid oxidation about the expression of enzyme and activity side
Face, and tea is submember in the compositions of the present invention.
The technology point of the present invention is to utilize tradition to have be used as medicine kind and the new resource food being eaten for a long time history
Being used in combination of raw material, according to the action character of each material, collocation uses, utilizes Experiment of Zoology to carry out activity
Screening finds combining form and the ratio to content of triglyceride in liver weight and liver with the effect of significantly reducing
Example.
Specific experiment method:
Take all-male kunming mice 90, be randomly divided into 6 groups: blank group (gavaging isometric(al) pure water), mould
Type group, liver-protecting tablet group (positive control, 2.88g/kg), the present composition are for examination group 1-3, for examination group 1
For low dose group (it is 0.5 times that the dilution of embodiment 1 concentrated liquid beverage makes concentration), supply examination group 2 for middle dosage
Group (embodiment 1 concentrated liquid beverage), confession examination group 3 are that (embodiment 1 concentrated liquid beverage is dense for low dose group
It is 2 times that contracting makes concentration).In addition to blank group gives isometric(al) distilled water, remaining respectively organizes the most every the most in the sky
Noon gastric infusion 1 time, gives 36 degree of Red Star Erguotou wines (20ml/kg) afternoon, continuous 46 days.Last is given
After medicine 1h, de-neck puts to death mice, takes out liver, exhausts with normal saline flushing and with filter paper, accurate with balance
Really weigh the weight of mouse liver, add 0.9g/l sodium chloride injection by the w/v of 1:10, use
Glass homogenizer makes the tissue homogenate of 100g/l, is centrifuged 5min with 3500r/min after homogenate, takes supernatant
Make 10% liver homogenate supernatant, measure triglyceride (TG) activity with homogenate.Knot is measured under this experiment condition
Fruit is shown in Table 1.
Table 1 present composition in liver weight and liver tissue homogenate TG content affect result
| Group | TG content (mmol/L) | Liver anharmonic ratio (%) |
| Blank group | 0.97±0.20 | 4.63±0.44 |
| Model group | 1.03±0.29 | 4.84±0.83 |
| Positive controls | 0.62±0.23 | 5.25±0.46 |
| For examination group 1 | 0.76±0.31 | 5.09±0.81 |
| For examination group 2 | 0.74±0.29 | 4.92±0.46 |
| For examination group 3 | 0.50±0.16 | 5.16±0.43 |
Results of animal under the conditions of the present invention shows: each dosage group does not has obvious shadow to mouse liver weight
Ring；(P ＜ 0.05) is significantly reduced, wherein for the effect of examination group 3 for the TG content in examination group experiment mice liver
Fruit is apparently higher than relatively positive controls.The result display present composition can carry out further investigation and develop into specific merit
Food, health food or the medicine of energy.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described further, but is not limited to embodiment.
Embodiment 1:
Reducing the concentrated liquid beverage of content of triglyceride in liver described in the present embodiment, raw material is by Rhizoma Imperatae
22.5 parts, Radix Puerariae 45 parts, 22.5 parts of Fructus Mori, Fructus Mume 9 parts, black tea 1 part, 80 parts of groups of maize oligopeptide
Become.
Rhizoma Imperatae, Radix Puerariae, Fructus Mori, Fructus Mume, black tea are picked and picks cleaning removal dust and impurity, adds 15 times
Amount concentration is the ethanol water of 30%, and 70 DEG C are extracted 1 hour, extract 2 times, and extracting solution is through 10000r/min
Filtering through ultrafilter membrane after Li Xin, filtrate makes solid content after concentrating at a temperature of 80 DEG C be 20%
Concentrated solution；Take maize oligopeptide to be dissolved in concentrated solution, mix homogeneously, make combination extracting solution；Addition group
Close stir subpackage, the sterilizing after filtration of extracting solution weight 50 times amount purified water and make concentrated liquid beverage.
Embodiment 2:
The health food of content of triglyceride, raw material Rhizoma Imperatae 15 parts, Pueraria lobota in liver is reduced described in the present embodiment
Root 40 parts, 15 parts of Fructus Mori, Fructus Mume 5 parts, Folium camelliae assamicae 1 part, maize oligopeptide 50 parts composition.
Rhizoma Imperatae, Radix Puerariae, Fructus Mori, Fructus Mume, Folium camelliae assamicae are picked to pick and clean, adds 8 times amount aqueous solutions, 100
DEG C extracting 0.5 hour, extracts 2 times, extracting solution is centrifugal through 5000r/min, filters through ultrafilter membrane,
Filtrate makes the concentrated solution that solid content is 10% after concentrating at a temperature of 80 DEG C；Take maize oligopeptide molten
Solution in concentrated solution, mix homogeneously, make combination extracting solution；Pure water is added by combination extracting solution 20 times amount,
Being stirred to dissolve full and uniform, subpackage after filtration, sterilizing make the oral liquid of 50ml/ bottle.
Embodiment 3:
Reduce the health food of content of triglyceride in liver described in the present embodiment, raw material by Rhizoma Imperatae 40 parts,
Radix Puerariae 60 parts, 40 parts of Fructus Mori, Fructus Mume 15 parts, oolong tea 8 parts, maize oligopeptide 110 parts composition.
Rhizoma Imperatae, Radix Puerariae, Fructus Mori, Fructus Mume, oolong tea are picked to pick and clean, adds 10 times amount aqueous solutions, 90
DEG C extracting 1 hour, extracts 1 time, extracting solution is centrifugal through 6000r/min, filters through ultrafilter membrane,
Filtrate makes the concentrated solution that solid content is 15% after concentrating at a temperature of 75 DEG C；Take maize oligopeptide molten
Solution in concentrated solution, mix homogeneously, make combination extracting solution；Combination extracting solution is made after concentrating further
Extractum, and it is separately added into sucrose and dextrin by extractum weight 3 times amount, make granule, dry subpackage i.e. obtains granule
The health food of agent form.
Embodiment 4:
Reducing the medicine of content of triglyceride in liver described in the present embodiment, raw material is by Rhizoma Imperatae 20 parts, Radix Puerariae
40 parts, 20 parts of Fructus Mori, Fructus Mume 6 parts, green tea 1 part, maize oligopeptide 70 parts composition.Take Rhizoma Imperatae,
Radix Puerariae, Fructus Mori, Fructus Mume, tea component mixing, adding 12 times amount concentration is the ethanol water of 25%, 75 DEG C
Extract 0.5 hour, extract 2 times, take extracting solution and be centrifuged through 5500r/min, then carried out through ultrafilter membrane
Filter, filtrate makes the concentrated solution that solid content is 20% after concentrating at a temperature of 80 DEG C；Take Semen Maydis oligomeric
Peptide is dissolved in concentrated solution, mix homogeneously, makes combination extracting solution；Combination extracting solution concentrates further to be made
Extractum, is separately added into dextrin and micropowder silica gel by extractum total amount 2 times amount, makes granule, loads hard capsule and is
Capsule.
Embodiment 5:
Reduce the health food of content of triglyceride in liver described in the present embodiment, raw material by Rhizoma Imperatae 25 parts,
Radix Puerariae 45 parts, 25 parts of Fructus Mori, Fructus Mume 10 parts, black tea 5 parts, maize oligopeptide 85 parts composition.
Rhizoma Imperatae, Radix Puerariae, Fructus Mori, Fructus Mume, black tea, black tea are picked to pick and cleans, extracting in water twice, first
Secondary adding 15 times of boiling pure water and extract 1 hour, second time adds 10 and is extracted 0.5 hour by boiling pure water, extracting solution
Being centrifuged through 9000r/min, filter through ultrafilter membrane, filtrate is made after concentrating at a temperature of 80 DEG C
Solid content is the concentrated solution of 18%；Take maize oligopeptide to be dissolved in concentrated solution, mix homogeneously, make group
Close extracting solution；It is condensed into the extractum of proportion 1.20 further, adds the starch and 10% of 25% by extractum weight
Sodium carboxymethyl cellulose and the Polyethylene Glycol of 5%, mix homogeneously pelletize after tabletting, must have reduction liver
The tablet of middle content of triglyceride.
Embodiment 6:
Reduce the bread and cheese of content of triglyceride in liver described in the present embodiment, raw material by Rhizoma Imperatae 35 parts,
Radix Puerariae 55 parts, 28 parts of Fructus Mori, Fructus Mume 12 parts, tea 3 parts, maize oligopeptide 55 parts composition.
Taking Rhizoma Imperatae, Radix Puerariae, Fructus Mori, Fructus Mume, tea component mixing, adding 12 times amount concentration is the second of 20%
Alcohol-water solution, 85 DEG C are extracted 0.5 hour, extract 2 times, take extracting solution and are centrifuged through 7000r/min, warp
Ultrafilter membrane filters, and filtrate makes the concentration that solid content is 15% after concentrating at a temperature of 50 DEG C
Liquid；Take maize oligopeptide to be dissolved in concentrated solution, mix homogeneously, make combination extracting solution；Add white sugar,
And 200 times of pure water, after mix homogeneously filtration, after filtrate flash-sterilization, bottling seals, and obtains applicable slight fat
The beverage that fat hepatopath eats.
Embodiment 7:
Reduce the health food of content of triglyceride in liver described in the present embodiment, raw material by Rhizoma Imperatae 23 parts,
Radix Puerariae 41 parts, 22.5 parts of Fructus Mori, Fructus Mume 8 parts, green tea 2 parts, maize oligopeptide 82 parts composition.
Take Rhizoma Imperatae, Radix Puerariae, Fructus Mori, Fructus Mume, tea component mixing, add 15 times amount pure water solutions, 100
DEG C extract 1 hour, extract 1 time, take extracting solution；It is centrifuged through 5000r/min, carried out through ultrafilter membrane
Filter, filtrate makes the concentrated solution that solid content is 20% after concentrating at a temperature of 75 DEG C；Take Semen Maydis oligomeric
Peptide is dissolved in concentrated solution, mix homogeneously, makes combination extracting solution；Combination extracting solution is condensed into extractum further.
Extractum makes extract powder through belt drying again, takes the fine powder of 200 mesh.Take 15 parts of gelatin and add distilled water 18
After part immersion expansion, addition glycerol 10 parts stirs and makes capsule material, takes the powder pressure mixed according to pressing
Soft capsule made by the type of making.
Embodiment 8:
The beverage of content of triglyceride in liver is reduced, by Rhizoma Imperatae 39 parts, Radix Puerariae 78 described in the present embodiment
Part, 39 parts of Fructus Mori, Fructus Mume 15.6 parts, black tea 2.4 parts, maize oligopeptide 120 parts composition.
Take Rhizoma Imperatae, Radix Puerariae, Fructus Mori, Fructus Mume, tea component mixing, add 10 times amount pure water solutions, 90 DEG C
Extract 0.5 hour, extract 2 times, take extracting solution and be centrifuged through 8000r/min, filter through ultrafilter membrane,
Filtrate makes the concentrated solution that solid content is 12% after concentrating at a temperature of 80 DEG C；Take maize oligopeptide molten
Solution in concentrated solution, mix homogeneously, make combination extracting solution；Adding the pure water of 180 times amount, stirring is all
Liquid beverage is i.e. prepared through secondary filter, subpackage, sterilizing after even.
Claims (4)
1. one kind has the compositions reducing liver tg content effect, it is characterised in that by following component
Composition: Rhizoma Imperatae 22.5 parts, Radix Puerariae 45 parts, 22.5 parts of Fructus Mori, Fructus Mume 9 parts, black tea 1 part, Semen Maydis
Oligopeptide 80 parts, is made up of following steps: Rhizoma Imperatae, Radix Puerariae, Fructus Mori, Fructus Mume, black tea is picked and picks cleaning
Removing dust and impurity, adding 15 times amount concentration is the ethanol water of 30%, and 70 DEG C are extracted 1 hour, carry
Taking 2 times, extracting solution filters through ultrafilter membrane after 10000r/min is centrifugal, and filtrate is at a temperature of 80 DEG C
The concentrated solution that solid content is 20% is made after concentrating；Take maize oligopeptide to be dissolved in concentrated solution, mixed
Close uniformly, make combination extracting solution；Addition combination extracting solution weight 50 times amount purified water stirs after filtration
Subpackage, sterilizing make concentrated liquid beverage.
There is compositions the most as claimed in claim 1 that reduce liver tg content effect at preparation food
Application in product.
There is compositions the most as claimed in claim 1 that reduce liver tg content effect protect in preparation
Application in health food.
The compositions the most as claimed in claim 1 with reduction liver tg content effect is preparing medicine
Application in product.
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