CN104435621A - Traditional Chinese medicine composition for treating suppurative tonsillitis and prepration method of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for treating suppurative tonsillitis and prepration method of traditional Chinese medicine composition Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating suppurative tonsillitis. The traditional Chinese medicine composition is mainly prepared from the following crude drugs in parts by weight: 0.3-0.6 part of raw gypsum, 0.8-1.6 parts of uncaria rhynchophylla, 0.6-1.5 parts of rhizoma anemarrhenae, 0.4-1.2 parts of uniflower swisscentaury root, 0.8-1.2 parts of ovalleaf aspidistra rhizome, 0.6-1.5 parts of manglietia fruit, 1.0-1.5 parts of catharanthus roseus, 1.0-2.0 parts of puerarin, 0.8-1.2 parts of paniculate swallowwort roots, 0.8-1.2 parts of momordica grosvenori, 0.3-0.6 part of sophora flower bud and 0.5-1.2 parts of schizonepeta spike. The traditional Chinese medicine composition disclosed by the invention is scientific in composition; the preparation method of various dosage forms is simple; and the obtained product is convenient to take.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to the tonsillitic Chinese medicine composition of a kind of therapeutic purulence and preparation method.
Background technology
Suppurative tonsillitis Main Pathogenic Bacteria is beta hemolytic streptococcus, staphylococcus, Diplococcus pneumoniae.Adenovirus also can cause primary disease.Antibacterial and virus mixed infection is quite a few sees.Antibacterial may be extraneous intrusion, also may be the antibacterial be hidden in tonsillar crypts, when Abwehrkraft des Koepers is because of cold, moist, overworked, and have a delicate constitution, tobacco and wine are excessive, when the factors such as harmful gas stimulation reduce suddenly, caused by bacterial reproduction is strengthened.Sometimes be then the prodrome of acute infectious disease, as measles and scarlet fever etc.Acute tonsillitis is acute attack repeatedly on chronic tonsil basis often.Its cardinal symptom is 1, the obvious enlargement of tonsil, and general congested and a large amount of neutrophil infiltration, is full of purulent exudate in crypts.2, pathological changes comparatively severe one, most lymph follicle increases, suppuration, forms multiple follicular abscess, and can wear out to crypts or surface, and form ulcer, microabscess also can merge, and causes whole tonsil to suppurate.3, onset is anxious, and high heat, pharyngalgia is obvious, when swallowing more so, can cause infant refusing to eat.4, check visible pharyngeal congestion, have yellow-white pus point or pus tongue above the tonsil of enlargement, cervical lymph node swells the obvious enlargement of tonsil, and general congested and a large amount of neutrophil infiltration, is full of purulent exudate in crypts.Pathological changes is severe one comparatively, and most lymph follicle increases, suppuration, forms multiple follicular abscess, and can wear out to crypts or surface, and form ulcer, microabscess also can merge, and causes whole tonsil to suppurate.Treat this disease, first-selected effective antibiotics, and select antipyretic analgesic to the ill, like this can antipyretic paroxysmal pain again, also help antimicrobial drug and play high-effect.
Publication No. CN 102614370 A(application number 201110205686.4) Chinese patent literature disclose a kind of Chinese medicine for the treatment of tonsillitis, pharyngolaryngitis, belong to the field of Chinese medicines.It is made up of the material combination of following portions by weight, Semen Sterculiae Lychnophorae 30-60 part, Radix Ophiopogonis 30-60 part, Radix Sophorae Tonkinensis 30-60 part, Herba Menthae 20-40 part, Radix Platycodonis 20-40 part.Publication No. CN 102988948 A(application number 201210534813.X) Chinese patent literature disclose a kind of medicament for the treatment of children's's suppurative tonsillitis, it is made up of the material of following weight proportioning: Herba Dracocephali Integrifolii 10-20 part, Ocimum Basilicum 5-15 part, Herba Solidaginis 1-15 part, Radix Notoginseng 1-10 part, Radix Saposhnikoviae 1-15 part, Herba Pteridis creticae 1-10 part, Rhizoma Zingiberis 1-10 part, Rhizoma Dioscoreae 1-15 part, Fructus Schisandrae Chinensis 1-10 part, Semen Hyoscyami 10-20 part, Radix Achyranthis Bidentatae 10-30 part, Flos Rosae Chinensis 1-20 part, Radix Et Rhizoma Nardostachyos 1-10 part, Rhizoma Menispermi 10-20 part and Rhizoma Curculiginis 1-10 part.Authorization Notice No. CN 103054928 A(application number 201210573928.X) Chinese patent literature disclose one and treat tonsillitic composition and method of making the same, compositions comprises following component: white turnip 200-300 gram; Fructus Canarii 4-6 gram; Flos Lonicerae 15-25 gram; White turnip is cleaned and thinly slices, Fructus Canarii smash after with Flos Lonicerae with loading in gauze bag, add clear water in iron pan appropriate, drop into Radix Raphani and bundle, with Sal a little, boil to white turnip soft rotten, drink soup.
In prior art, the tonsillitic method of therapeutic purulence has a lot, and doctor trained in Western medicine is antibiotic to be widely used, and comparatively large to harm, Chinese medicine is applicable to this disease more, therefore also requires further study for suppurative tonsillitic Chinese medicine composition.
Summary of the invention
For the problem of prior art, the object of this invention is to provide a kind of Be very effective, take the tonsillitic Chinese medicine composition of therapeutic purulence had no side effect safely.
Technical scheme of the present invention is:
The tonsillitic Chinese medicine composition of therapeutic purulence, is prepared from primarily of following bulk drugs, is weight portion: Gypsum Fibrosum 0.3-0.6; Ramulus Uncariae Cum Uncis 0.8-1.6; Rhizoma Anemarrhenae 0.6-1.5; Radix Rhapontici 0.4-1.2; Rhizoma aspidistrae typicae 0.8-1.2; Fructus Manglietiae fordianae 0.6-1.5; Herba Catharanthi Rosei 1.0-1.5; Radix Puerariae 1.0-2.0; Radix Cynanchi Paniculati 0.8-1.2; Fructus Momordicae 0.8-1.2; Flos Sophorae Immaturus 0.3-0.6; Herba Schizonepetae 0.5-1.2.
Preferred: Gypsum Fibrosum 0.4-0.5; Ramulus Uncariae Cum Uncis 1.0-1.4; Rhizoma Anemarrhenae 0.8-1.3; Radix Rhapontici 0.6-1.0; Rhizoma aspidistrae typicae 0.9-1.1; Fructus Manglietiae fordianae 0.8-1.3; Herba Catharanthi Rosei 1.1-1.4; Radix Puerariae 1.2-1.8; Radix Cynanchi Paniculati 0.9-1.1; Fructus Momordicae 0.9-1.1; Flos Sophorae Immaturus 0.4-0.5; Herba Schizonepetae 0.7-1.0.
Be more preferably: Gypsum Fibrosum 0.45; Ramulus Uncariae Cum Uncis 1.2; The Rhizoma Anemarrhenae 1.05; Radix Rhapontici 0.8; Rhizoma aspidistrae typicae 1.5; Fructus Manglietiae fordianae 1.05; Herba Catharanthi Rosei 1.25; Radix Puerariae 1.5; Radix Cynanchi Paniculati 1.0; Fructus Momordicae 1.0; The Flos Sophorae Immaturus 0.45; Herba Schizonepetae 0.85.
The preparation method of described therapeutic purulence tonsillitic Chinese medicine composition decoction is as follows:
(1) get Gypsum Fibrosum, remove impurity is cleaned, and dries to smash to be placed in mortar, adds clear water and grinds to form pasty state, continues to add water and constantly stirs, topple over suspension; Repeatable operation, to the greasy shape of porphyrize, merges suspension, leaves standstill the supernatant that inclines, dries;
(2) get Testa Tritici and put into pot, moderate heat is heated to smolder, more clean Ramulus Uncariae Cum Uncis, the Rhizoma Anemarrhenae, Radix Rhapontici, Rhizoma aspidistrae typicae, Radix Puerariae and Radix Cynanchi Paniculati are cut sheet, mixes, constantly stir with Testa Tritici, and it is (preferred: the time of stirring is 20-25 minute that the time is 15-30 minute; Be more preferably: the time of stirring is 23 minutes), take out, sieve remove Testa Tritici, dry in the air cool;
(3) by step (2) made Chinese crude drug and gypsum powder, add the soak by water of medical material weight 7 times, big fire is heated, and adds Herba Catharanthi Rosei, the Flos Sophorae Immaturus and Herba Schizonepetae again after boiling, turns little fire and decocts 40-60 minute (preferably: little fire decocts 45-55 minute; Be more preferably: little fire decocts 50 minutes), filtered while hot obtains filtrate;
(4) Fructus Manglietiae fordianae and Fructus Momordicae are added water steaming and decocting 50-70 minute (preferably: steaming and decocting 55-65 minute; Be more preferably: steaming and decocting 60 minutes), take out after cooling and peel off skin, pulverize, then add alcohol-pickled 20 minutes after drying, filter, heating evaporation reclaims ethanol extremely without alcohol taste;
(5) blend step (3) (4) gained filtrate and medicated powder, sterilizing encapsulation obtains Chinese medicine composition decoction.
The preparation method of described decoction, in step (4), ethanol amount is the 3-5 of medical material weight doubly (preferred: ethanol amount is 4 times of medical material weight).
The preparation method of the tonsillitic Chinese medicine composition composition powders of described therapeutic purulence is:
(1) get Gypsum Fibrosum, remove impurity is cleaned, and dries to smash to be placed in mortar, adds clear water and grinds to form pasty state, continues to add water and constantly stirs, topple over suspension; Repeatable operation, to the greasy shape of porphyrize, merges suspension, leaves standstill the supernatant that inclines, dries;
(2) get Testa Tritici and put into pot, moderate heat is heated to smolder, then the Ramulus Uncariae Cum Uncis cleaned, the Rhizoma Anemarrhenae, Radix Rhapontici, Rhizoma aspidistrae typicae, Radix Puerariae, Radix Cynanchi Paniculati, Herba Catharanthi Rosei, the Flos Sophorae Immaturus and Herba Schizonepetae is cut into slices, and mixes with Testa Tritici, constantly stir, it is (preferred: the time of stirring is 20-25 minute that the time is 15-30 minute; Be more preferably: the time of stirring is 23 minutes), take out, sieve remove Testa Tritici, dry in the air cool;
(3) Fructus Manglietiae fordianae and Fructus Momordicae are cleaned remove impurity, grind to form pureed, heating, with oil-Absorbing Sheets parcel, oil is removed in squeezing, until medicine does not glue, forms cake and be as the criterion;
(4) by medicine made to step (2) (3), carefully grind to form fine powder, mix with step (1) gained gypsum powder, sieve, obtain Chinese medicine composition composition powders.
The preparation method of described powder, in step (4), the order number of sieve is that 100-140(is preferred: the order number of sieve is 110-130; Be more preferably: the order number of sieve is 120).
Described therapeutic purulence tonsillitic Chinese medicine composition pill preparation method is:
(1) get Gypsum Fibrosum, remove impurity is cleaned, and dries to smash to be placed in mortar, adds clear water and grinds to form pasty state, continues to add water and constantly stirs, topple over suspension; Repeatable operation, to the greasy shape of porphyrize, merges suspension, leaves standstill the supernatant that inclines, dries;
(2) get Testa Tritici and put into pot, moderate heat is heated to smolder, then the Ramulus Uncariae Cum Uncis cleaned, the Rhizoma Anemarrhenae, Radix Rhapontici, Rhizoma aspidistrae typicae, Radix Puerariae, Radix Cynanchi Paniculati, Herba Catharanthi Rosei, the Flos Sophorae Immaturus and Herba Schizonepetae is cut into slices, and mixes with Testa Tritici, constantly stir, it is (preferred: the time of stirring is 20-25 minute that the time is 15-30 minute; Be more preferably: the time of stirring is 23 minutes), take out, sieve remove Testa Tritici, dry in the air cool;
(3) Fructus Manglietiae fordianae and Fructus Momordicae are cleaned remove impurity, grind to form pureed, heating, with oil-Absorbing Sheets parcel, oil is removed in squeezing, until medicine does not glue, forms cake and be as the criterion;
(4) by step (2) (3) made medical material, carefully pulverize, mix with step (1) gained gypsum powder, cross 120 mesh sieves, add refined honey, fully with even, bar processed, one-tenth ball, packaging, obtain Chinese medicine composition pill.
The preparation method of described pill, the ratio of step (4) Chinese medicine powder and refined honey is that 1:1-1:1.5(is preferred: the ratio of medicated powder and refined honey is 1:1.2).
The preparation method of the described tonsillitic Traditional Chinese medicine composition paste of therapeutic purulence is:
(1) get Gypsum Fibrosum, remove impurity is cleaned, and dries to smash to be placed in mortar, adds clear water and grinds to form pasty state, continues to add water and constantly stirs, topple over suspension; Repeatable operation, to the greasy shape of porphyrize, merges suspension, leaves standstill the supernatant that inclines, dries;
(2) get Testa Tritici and put into pot, moderate heat is heated to smolder, more clean Ramulus Uncariae Cum Uncis, the Rhizoma Anemarrhenae, Radix Rhapontici, Rhizoma aspidistrae typicae, Radix Puerariae and Radix Cynanchi Paniculati are cut sheet, mixes, constantly stir with Testa Tritici, and it is (preferred: the time of stirring is 20-25 minute that the time is 15-30 minute; Be more preferably: the time of stirring is 23 minutes), take out, sieve remove Testa Tritici, dry in the air cool;
(3) by step (2) made Chinese crude drug and gypsum powder, decoct with water, big fire is heated, and adds Herba Catharanthi Rosei, the Flos Sophorae Immaturus and Herba Schizonepetae again after boiling, turns little fire and decocts 40-60 minute (preferably: little fire decocts 45-55 minute; Be more preferably: little fire decocts 50 minutes), filtered while hot obtains filtrate;
(4) Fructus Manglietiae fordianae and Fructus Momordicae are added water steaming and decocting 50-70 minute (preferably: steaming and decocting 55-65 minute; Be more preferably: steaming and decocting 60 minutes), take out and pulverize into pureed;
(5) blend step (3) (4) gains, heating under reduced pressure is concentrated into the paste that relative density is 1.22, obtains Traditional Chinese medicine composition paste.
The preparation method of described unguentum, in step (3), amount of water is that the 6-9 of medical material weight is doubly (preferred: amount of water is 7-8 times of medical material weight; Be more preferably: amount of water is 7.5 times of medical material weight).
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Gypsum Fibrosum: Gypsum Fibrosum is monoclinic system mineral, main chemical compositions is calcium sulfate (CaSO
4) hydrate.Gypsum Fibrosum is natural dihydrate gypsum (CaSO both
42H
2o).Nature and flavor: pungent, sweet, are slightly cold.Attach to the lung and stomach meridians.Have clearing away heat-fire, relieving restlessness is quenched the thirst, effect of convergence granulation promoting.Cure mainly: apoplexy cold and heat, heart subinverse gas is frightened to be breathed heavily, and xerostomia scorching tongue, can not cease, hardness and fullness in the abdomen pain, evil removing ghost, puerperium incised wound.Except seasonal epidemic pathogens headache fever of the body, three burnt large heat, skin heat, stagnation of QI in the intestines and stomach, expelling pathogenic factors from muscles by diaphoresis, restlessness accompanied by ascending of QI of only quenching one's thirst, the sudden and violent gas of abdominal distention, pharynx heat of panting, also can do bath soup.Cure the wound cold headache as split.Simmer tea with Herba Alii fistulosi, pain of decaptitating.Control sky capable fanatic, wind syndrome of head revolves, stimulating milk secretion, wipes tooth benefit tooth.Except gastric heat lung-heat, loose YIN pathogen, slow spleen QI invigorating.Only Yangming Channel headache, fever with chills, day feeds hectic fever, and drinking a large amount of water due to extreme thirst, heatstroke hectic fever, has a toothache.
Ramulus Uncariae Cum Uncis: nature and flavor with return through: sweet, cool.Return liver, pericardium channel.There is dispelling wind and relieving convulsion, effect of heat clearing away suppressing the hyperactive liver.For liver-wind stirring up internally, infantile convulsion is twitched, and hyperpyrexia convulsion, dysphoric cold, children's's night crying due to fright in infant, pre-eclampsia, has a headache dizzy.
The Rhizoma Anemarrhenae: nature and flavor: bitter, sweet, cold.Return lung, stomach, kidney channel.There is clearing away heat-fire, nourshing Yin and drynsessmoistening prescription effect.For fever caused by exogenous pathogenic factors, high hot excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat is quenched one's thirst, dryness of the intestine constipation.
Radix Rhapontici: base is former: be the dry root of feverfew centaurea monanthos Georgi.Nature and flavor with return through: bitter, cold.Return stomach warp.Function with cure mainly: heat-clearing and toxic substances removing, eliminating carbuncle, stimulating milk secretion, relaxing muscles and tendons is promoted blood circulation.Swell and ache for acute mastitis, carbuncle carbuncle on the back, scrofula sore, galactostasis, arthralgia chiefly caused by damp pathogen contracture.
Rhizoma aspidistrae typicae: base is former: be the rhizome of liliaceous plant Rhizoma aspidistrae typicae.The whole year can adopt.Nature and flavor: toil, temperature.Function cures mainly: promoting blood circulation to remove blood stasis, synthetism, pain relieving, heat-clearing and toxic substances removing.Control dysentery, malaria, rheumatic arthralgia, kidney deficiency lumbocrural pain, osteopatia sprain, fracture, venom.
Fructus Manglietiae fordianae: base is former: be the fruit of Magnoliaceae Manglietia plant Fructus Fici Pumilae.Composition: mainly contain Palmic acid, oleic acid, linoleic acid.The property of medicine: 1, " Tian Mu Shan Mountain medicinal plants will ": " there is fragrant gas, lightly seasoned." 2, " national Chinese herbal medicine compilation ": " cough-relieving, relieving constipation." function cures mainly: relieving constipation, cough-relieving.Cure mainly excess-heat constipation, old man coughs.
Herba Catharanthi Rosei: base is former: be Apocynaceae periwinkle plant Herba Catharanthi Rosei, the herb of yellow Herba Catharanthi Rosei.Composition: plant containing indoles alkaloid more than 70 in Herba Catharanthi Rosei, comprise vinblastine, vincristine, lochnericine, lochnericine, remove acetyl vindorosine, vincaleucoblastine, Changchun Buddhist nun is fixed, lochnerinine etc.Root containing alkaloid, comprises that 9-methoxycorynantheidine., akuammicine, west, Changchun are fixed, lochnerivine, cavineine sulfate, sulphuric acid stay around western language alkali, and ammocalline, sulphuric acid group is around raw etc.Pharmacology: 1. antitumor action Herba Catharanthi Rosei contains vinblastine, vincristine, leurosine, leurosidine have obvious antitumor action.2. Antitumor Mechanism Herba Catharanthi Rosei antitumor action is directly relevant to the high-affinity of tubulin binding with medicine, suppress nucleic acid synthesis be it another mechanism.No matter 3. blood pressure lowering and vasodilative effect catharanthus roseus total alkaloids gavage, intramuscular injection or quiet note all have hypotensive effect to anesthetized dog, also has the effect of expansion coronary vasodilator.4. the water extract of blood sugar lowering and effect for reducing blood fat this product leaf has normal or alloxan diabetes rabbit and dog and reduces blood glucose effect.The property of medicine: bitter, cold, poisonous.Function cures mainly: detoxicating and fighting cancer, heat clearing away suppressing the hyperactive liver.Cure mainly multiple cancerous protuberance, hypertension, carbuncle sore tumefacting virus, scald.
Radix Puerariae: nature and flavor: sweet, pungent, cool.Gui Jing: return spleen, stomach warp.Effect: expelling pathogenic factors from muscles for reducing heat, promotes the production of body fluid, rash, yang invigorating antidiarrheal.Cure mainly: for fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, has loose bowels; Hypertension neck pain.
Radix Cynanchi Paniculati: base is former: be the dry root welding technology of Luo Mo section plant Radix Cynanchi Paniculati.Nature and flavor with return through: pungent, temperature.Return liver, stomach warp.Function with cure mainly: dispel the wind, removing dampness, pain relieving, antipruritic.For rheumatic arthralgia, stomachache distension, toothache, lumbago, falls and flutters the pain of injury, rubella, eczema.
Fructus Momordicae: base is former: be the dry fruit of cucurbitaceous plant Fructus Momordicae.Autumn gathers when fruit deepens green by peak green, after a couple of days of drying in the air, and cold drying.Nature and flavor with return through: sweet, cool.Return lung, large intestine channel.Function with cure mainly: clearing heat and moistening lung, relieving sore throat to recover voice, laxation relieving constipation.For lung-heat type cough, pharyngalgia aphonia, dryness of the intestine constipation.
The Flos Sophorae Immaturus: base is former: the alabastrum of leguminous plant Chinese scholartree.Summer gathers when alabastrum is formed, dry in time, except debranching, stalk and impurity.Nature and flavor with return through: cold, sweet in the mouth put down; Enter liver, large intestine channel; There is cooling blood for hemostasis, effect of liver heat removing pathogenic fire reducing; Cure mainly discharging fresh blood stool, hemorrhoidal bleeding, hematuria, stranguria with blood, metrorrhagia, blood, dysentery with red and white feces, conjunctival congestion, sore, the diseases such as hypertension.
Herba Schizonepetae: nature and flavor: pungent, tepor.Return lung, Liver Channel.There is the loose wind that induces sweat, rash, the effect of the skin ulcer that disappears.For flu, headache, measles, rubella, skin infection from the beginning of.
The tonsillitic Traditional Chinese medicine composition formula science of therapeutic purulence provided by the invention, preparation method is simple.In addition, its excellent part also shows:
1, the various dosage form drug effect of gained of the present invention rapidly, reliable effect;
2, this Chinese medicine has heat-clearing and toxic substances removing, skin ulcer is dispelled in detumescence, stable curative effect, anti-recurrence;
3, medicine of the present invention is natural Chinese medicines material, has no side effect to human body.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1the tonsillitic Chinese medicine composition of therapeutic purulence, is prepared from primarily of following bulk drugs: Gypsum Fibrosum 3g, Ramulus Uncariae Cum Uncis 8g, Rhizoma Anemarrhenae 6g, Radix Rhapontici 4g, Rhizoma aspidistrae typicae 8g, Fructus Manglietiae fordianae 6g, Herba Catharanthi Rosei 10g, Radix Puerariae 10g, Radix Cynanchi Paniculati 8g, Fructus Momordicae 8g, Flos Sophorae Immaturus 3g, Herba Schizonepetae 5g.The preparation method of the tonsillitic Chinese medicine composition decoction of above-mentioned therapeutic purulence is:
(1) get Gypsum Fibrosum, remove impurity is cleaned, and dries to smash to be placed in mortar, adds clear water and grinds to form pasty state, continues to add water and constantly stirs, topple over suspension; Repeatable operation, to the greasy shape of porphyrize, merges suspension, leaves standstill the supernatant that inclines, dries;
(2) get Testa Tritici and put into pot, moderate heat is heated to smolder, more clean Ramulus Uncariae Cum Uncis, the Rhizoma Anemarrhenae, Radix Rhapontici, Rhizoma aspidistrae typicae, Radix Puerariae and Radix Cynanchi Paniculati are cut sheet, mixes, constantly stir with Testa Tritici, and the time is 20 minutes, take out, sieve remove Testa Tritici, dry in the air cool;
(3) by step (2) made Chinese crude drug and gypsum powder, add the soak by water of medical material weight 7 times, big fire is heated, and adds Herba Catharanthi Rosei, the Flos Sophorae Immaturus and Herba Schizonepetae again after boiling, and turn little fire and decoct 40 minutes, filtered while hot obtains filtrate;
(4) add water Fructus Manglietiae fordianae and Fructus Momordicae steaming and decocting 50 minutes, takes out after cooling and peel off skin, pulverize, then add alcohol-pickled 20 minutes of medical material weight 3 times after drying, filter, and heating evaporation reclaims ethanol extremely without alcohol taste;
(5) blend step (3) (4) gained filtrate and medicated powder, sterilizing encapsulation obtains Chinese medicine composition decoction.
embodiment 2the tonsillitic Chinese medicine composition of therapeutic purulence, is prepared from primarily of following bulk drugs: Gypsum Fibrosum 6g, Ramulus Uncariae Cum Uncis 16g, Rhizoma Anemarrhenae 15g, Radix Rhapontici 12g, Rhizoma aspidistrae typicae 12g, Fructus Manglietiae fordianae 15g, Herba Catharanthi Rosei 15g, Radix Puerariae 20g, Radix Cynanchi Paniculati 12g, Fructus Momordicae 12g, Flos Sophorae Immaturus 6g, Herba Schizonepetae 12g.The preparation method of the tonsillitic Chinese medicine composition composition powders of above-mentioned therapeutic purulence is:
(1) get Gypsum Fibrosum, remove impurity is cleaned, and dries to smash to be placed in mortar, adds clear water and grinds to form pasty state, continues to add water and constantly stirs, topple over suspension; Repeatable operation, to the greasy shape of porphyrize, merges suspension, leaves standstill the supernatant that inclines, dries;
(2) get Testa Tritici and put into pot, moderate heat is heated to smolder, then the Ramulus Uncariae Cum Uncis cleaned, the Rhizoma Anemarrhenae, Radix Rhapontici, Rhizoma aspidistrae typicae, Radix Puerariae, Radix Cynanchi Paniculati, Herba Catharanthi Rosei, the Flos Sophorae Immaturus and Herba Schizonepetae is cut into slices, mix with Testa Tritici, constantly stir, the time is 23 minutes, take out, sieve remove Testa Tritici, dry in the air cool;
(3) Fructus Manglietiae fordianae and Fructus Momordicae are cleaned remove impurity, grind to form pureed, heating, with oil-Absorbing Sheets parcel, oil is removed in squeezing, until medicine does not glue, forms cake and be as the criterion;
(4) by medicine made to step (2) (3), carefully grind to form fine powder, mix with step (1) gained gypsum powder, cross 120 mesh sieves, obtain Chinese medicine composition composition powders.
Model case: xxx, women, 27 years old.Main suit: patient's laryngopharynx swelling and pain, and generate heat three days with hyperpyrexia., there is the symptom such as pharyngalgia, heating in medical history: patient travelled outdoors before three days, dysphagia when having a meal after going home, spirit is poor.Through examination in hospital, find its pharyngeal congestion, bilateral amygdala enlargement, be diagnosed as suppurative tonsillitis.
Take this example gained Chinese medicine composition composition powders, every day takes twice, a 5g/ bag, warm boiled water, within five days, is a course for the treatment of.After three days, patient's pharyngeal pain alleviates, and temperature recovery is to normal, and continue to take two courses for the treatment of, can normally have a meal, each index of health check-up is all qualified, and patient fully recovers.
embodiment 3the tonsillitic Chinese medicine composition of therapeutic purulence, is prepared from primarily of following bulk drugs: Gypsum Fibrosum 4g, Ramulus Uncariae Cum Uncis 10g, Rhizoma Anemarrhenae 8g, Radix Rhapontici 6g, Rhizoma aspidistrae typicae 9g, Fructus Manglietiae fordianae 8g, Herba Catharanthi Rosei 11g, Radix Puerariae 12g, Radix Cynanchi Paniculati 9g, Fructus Momordicae 9g, Flos Sophorae Immaturus 4g, Herba Schizonepetae 7g.The preparation method of the tonsillitic Chinese medicine composition pill of above-mentioned therapeutic purulence is:
(1) get Gypsum Fibrosum, remove impurity is cleaned, and dries to smash to be placed in mortar, adds clear water and grinds to form pasty state, continues to add water and constantly stirs, topple over suspension; Repeatable operation, to the greasy shape of porphyrize, merges suspension, leaves standstill the supernatant that inclines, dries;
(2) get Testa Tritici and put into pot, moderate heat is heated to smolder, then the Ramulus Uncariae Cum Uncis cleaned, the Rhizoma Anemarrhenae, Radix Rhapontici, Rhizoma aspidistrae typicae, Radix Puerariae, Radix Cynanchi Paniculati, Herba Catharanthi Rosei, the Flos Sophorae Immaturus and Herba Schizonepetae is cut into slices, mix with Testa Tritici, constantly stir, the time is 23 minutes, take out, sieve remove Testa Tritici, dry in the air cool;
(3) Fructus Manglietiae fordianae and Fructus Momordicae are cleaned remove impurity, grind to form pureed, heating, with oil-Absorbing Sheets parcel, oil is removed in squeezing, until medicine does not glue, forms cake and be as the criterion;
(4) by step (2) (3) made medical material, carefully pulverize, mix with step (1) gained gypsum powder, cross 120 mesh sieves, according to the ratio of medicated powder and refined honey 1:1.2, fully and even, bar processed, one-tenth ball, packaging, obtain Chinese medicine composition pill.
Model case: xxx, male, 36 years old.Medical history: patient recurrent cough, have expectorant one month, nearly three days aggravations, and there is low grade fever's phenomenon; Have a medical check-up: body temperature 37.9 degree, face is turned to be yellow, pharyngeal congestion, visible purulent secretion, and all the other physical and chemical indexs are normal; Be diagnosed as: acute suppurative tonsillitis.
Take this example gained medicine pill, twice daily, once two, warm boiled water five days is a course for the treatment of.After the course for the treatment of, patient's pharyngeal congestion alleviates, and secretions reduces, and continue use after five days, clinical symptoms substantially all disappears, and each index all returns to normally on inspection, and patient fully recovers.
embodiment 4the tonsillitic Chinese medicine composition of therapeutic purulence, is prepared from primarily of following bulk drugs: Gypsum Fibrosum 5g, Ramulus Uncariae Cum Uncis 14g, Rhizoma Anemarrhenae 13g, Radix Rhapontici 10g, Rhizoma aspidistrae typicae 11g, Fructus Manglietiae fordianae 13g, Herba Catharanthi Rosei 14g, Radix Puerariae 18g, Radix Cynanchi Paniculati 11g, Fructus Momordicae 11g, Flos Sophorae Immaturus 5g, Herba Schizonepetae 10g.The preparation method of the tonsillitic Traditional Chinese medicine composition paste of above-mentioned therapeutic purulence is:
(1) get Gypsum Fibrosum, remove impurity is cleaned, and dries to smash to be placed in mortar, adds clear water and grinds to form pasty state, continues to add water and constantly stirs, topple over suspension; Repeatable operation, to the greasy shape of porphyrize, merges suspension, leaves standstill the supernatant that inclines, dries;
(2) get Testa Tritici and put into pot, moderate heat is heated to smolder, more clean Ramulus Uncariae Cum Uncis, the Rhizoma Anemarrhenae, Radix Rhapontici, Rhizoma aspidistrae typicae, Radix Puerariae and Radix Cynanchi Paniculati are cut sheet, mixes, constantly stir with Testa Tritici, and the time is 23 minutes, take out, sieve remove Testa Tritici, dry in the air cool;
(3) by step (2) made Chinese crude drug and gypsum powder, add the soak by water of medical material weight 7.5 times, big fire is heated, and adds Herba Catharanthi Rosei, the Flos Sophorae Immaturus and Herba Schizonepetae again after boiling, and turn little fire and decoct 50 minutes, filtered while hot obtains filtrate;
(4) add water Fructus Manglietiae fordianae and Fructus Momordicae steaming and decocting 60 minutes, takes out and pulverize into pureed;
(5) blend step (3) (4) gains, heating under reduced pressure is concentrated into the paste that relative density is 1.22, obtains Traditional Chinese medicine composition paste.
Model case: xxx, man, 54 years old.Medical history: patient must have tonsillitis 5 years, Relapse rate shows effect, and frequent intravenous injection drop carrys out relief of symptoms, in the recent period because antiadoncus and pain are gone to a doctor.Have a medical check-up: red swelling of the pharynx, have the visible secretions of purulence, hoarseness, tired out weak, tongue fur is dark yellow; Be diagnosed as suppurative tonsillitis.
Recommend through doctor, take this example gained Chinese medicinal ointment, twice daily, once two soup ladles (about 5g), warm boiled water.Take two courses for the treatment of, patient's tonsil pain and enlargement all disappear, and without secretions, energy improves, and after continuing to strengthen a course for the treatment of, patient fully recovers, and follows up a case by regular visits in two years, without recurrence.
embodiment 5the tonsillitic Chinese medicine composition of therapeutic purulence, is prepared from primarily of following bulk drugs: Gypsum Fibrosum 4.5g, Ramulus Uncariae Cum Uncis 12g, Rhizoma Anemarrhenae 10.5g, Radix Rhapontici 8g, Rhizoma aspidistrae typicae 15g, Fructus Manglietiae fordianae 10.5g, Herba Catharanthi Rosei 12.5g, Radix Puerariae 15g, Radix Cynanchi Paniculati 10g, Fructus Momordicae 10g, Flos Sophorae Immaturus 4.5g, Herba Schizonepetae 8.5g.The preparation method of the tonsillitic Chinese medicine composition decoction of above-mentioned therapeutic purulence is:
(1) get Gypsum Fibrosum, remove impurity is cleaned, and dries to smash to be placed in mortar, adds clear water and grinds to form pasty state, continues to add water and constantly stirs, topple over suspension; Repeatable operation, to the greasy shape of porphyrize, merges suspension, leaves standstill the supernatant that inclines, dries;
(2) get Testa Tritici and put into pot, moderate heat is heated to smolder, more clean Ramulus Uncariae Cum Uncis, the Rhizoma Anemarrhenae, Radix Rhapontici, Rhizoma aspidistrae typicae, Radix Puerariae and Radix Cynanchi Paniculati are cut sheet, mixes, constantly stir with Testa Tritici, and the time is 23 minutes, take out, sieve remove Testa Tritici, dry in the air cool;
(3) by step (2) made Chinese crude drug and gypsum powder, add the soak by water of medical material weight 7 times, big fire is heated, and adds Herba Catharanthi Rosei, the Flos Sophorae Immaturus and Herba Schizonepetae again after boiling, and turn little fire and decoct 50 minutes, filtered while hot obtains filtrate;
(4) add water Fructus Manglietiae fordianae and Fructus Momordicae steaming and decocting 60 minutes, takes out after cooling and peel off skin, pulverize, then add alcohol-pickled 20 minutes of medical material weight 4 times after drying, filter, and heating evaporation reclaims ethanol extremely without alcohol taste;
(5) blend step (3) (4) gained filtrate and medicated powder, sterilizing encapsulation obtains Chinese medicine composition decoction.
test example 1the clinical practice of the tonsillitic Chinese medicine composition decoction of the therapeutic purulence of embodiment 5 gained: according to hospital outpatient case history, screens suppurative tonsillitis patient 420 example, wherein women 200 example, male 220 example, oldest 60 years old, minimum 10 years old, 32.5 years old mean age.Before test, Continuous Observation is carried out to this crowd, record symptom and change.
Test method: be divided into two groups at random, experimental group 264 people, matched group 156 people.Experimental group uses embodiment five gained Chinese medicine decoction, and take twice every day, one time 50-100ml(decides as circumstances require), take while hot; Matched group uses other conventional methods (cephalo, amoxicillin, penicillin, QINGKAILING etc.).
Curative effect determinate standard: cure: sore throat, heating paresthesia disappear, tonsil checks no pus point, does not recur; Effective: sore throat symptom obviously alleviates, occasionally there is recurrence; Invalid: clinical symptoms is front without changing with treatment.Total effective rate=cure rate+effective percentage.
After using for two each and every one courses for the treatment of, clinical effectiveness is as shown in table 1:
Can be obtained by table 1, after treating two courses for the treatment of, experimental group: cure rate 73.9%, effective percentage 24.2%, total effective rate 98.1%; And matched group: cure rate 59.6%, effective percentage 24.4%, total effective rate 84%, successful is not as experimental group, and result shows, gained Chinese medicine decoction of the present invention is for the curative effect that suppurative tonsillitis has good reducing swelling and alleviating pain, pus is removed in heat clearing away.
The present invention is theoretical according to differential diagnosis in tcm, multiple medical material synergistic combination, the removing toxic substances of the Ramulus Uncariae Cum Uncis heat clearing away suppressing the hyperactive liver used in side, Rhizoma aspidistrae typicae pain relieving, Radix Puerariae promote the production of body fluid rash, all medicines share, therapeutic purulence tonsillitis targetedly, therapeutic effect is remarkable, and its relapse rate of clinical trial certificate is 0%, far below 9% of matched group, the condition for the treatment of Patients Before And After also obviously improves.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. the tonsillitic Chinese medicine composition of therapeutic purulence, is characterized in that, be prepared from primarily of following bulk drugs, be weight portion: Gypsum Fibrosum 0.3-0.6; Ramulus Uncariae Cum Uncis 0.8-1.6; Rhizoma Anemarrhenae 0.6-1.5; Radix Rhapontici 0.4-1.2; Rhizoma aspidistrae typicae 0.8-1.2; Fructus Manglietiae fordianae 0.6-1.5; Herba Catharanthi Rosei 1.0-1.5; Radix Puerariae 1.0-2.0; Radix Cynanchi Paniculati 0.8-1.2; Fructus Momordicae 0.8-1.2; Flos Sophorae Immaturus 0.3-0.6; Herba Schizonepetae 0.5-1.2.
2. the tonsillitic Chinese medicine composition of therapeutic purulence as claimed in claim 1, is characterized in that, Gypsum Fibrosum 0.4-0.5; Ramulus Uncariae Cum Uncis 1.0-1.4; Rhizoma Anemarrhenae 0.8-1.3; Radix Rhapontici 0.6-1.0; Rhizoma aspidistrae typicae 0.9-1.1; Fructus Manglietiae fordianae 0.8-1.3; Herba Catharanthi Rosei 1.1-1.4; Radix Puerariae 1.2-1.8; Radix Cynanchi Paniculati 0.9-1.1; Fructus Momordicae 0.9-1.1; Flos Sophorae Immaturus 0.4-0.5; Herba Schizonepetae 0.7-1.0(is preferably: Gypsum Fibrosum 0.45; Ramulus Uncariae Cum Uncis 1.2; The Rhizoma Anemarrhenae 1.05; Radix Rhapontici 0.8; Rhizoma aspidistrae typicae 1.5; Fructus Manglietiae fordianae 1.05; Herba Catharanthi Rosei 1.25; Radix Puerariae 1.5; Radix Cynanchi Paniculati 1.0; Fructus Momordicae 1.0; The Flos Sophorae Immaturus 0.45; Herba Schizonepetae 0.85).
3. the tonsillitic Chinese medicine composition of therapeutic purulence as described in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) get Gypsum Fibrosum, remove impurity is cleaned, and dries to smash to be placed in mortar, adds clear water and grinds to form pasty state, continues to add water and constantly stirs, topple over suspension; Repeatable operation, to the greasy shape of porphyrize, merges suspension, leaves standstill the supernatant that inclines, dries;
(2) get Testa Tritici and put into pot, moderate heat is heated to smolder, more clean Ramulus Uncariae Cum Uncis, the Rhizoma Anemarrhenae, Radix Rhapontici, Rhizoma aspidistrae typicae, Radix Puerariae and Radix Cynanchi Paniculati are cut sheet, mixes, constantly stir with Testa Tritici, and it is (preferred: the time of stirring is 20-25 minute that the time is 15-30 minute; Be more preferably: the time of stirring is 23 minutes), take out, sieve remove Testa Tritici, dry in the air cool;
(3) by step (2) made Chinese crude drug and gypsum powder, add the soak by water of medical material weight 7 times, big fire is heated, and adds Herba Catharanthi Rosei, the Flos Sophorae Immaturus and Herba Schizonepetae again after boiling, turns little fire and decocts 40-60 minute (preferably: little fire decocts 45-55 minute; Be more preferably: little fire decocts 50 minutes), filtered while hot obtains filtrate;
(4) Fructus Manglietiae fordianae and Fructus Momordicae are added water steaming and decocting 50-70 minute (preferably: steaming and decocting 55-65 minute; Be more preferably: steaming and decocting 60 minutes), take out after cooling and peel off skin, pulverize, then add alcohol-pickled 20 minutes after drying, filter, heating evaporation reclaims ethanol extremely without alcohol taste;
(5) blend step (3) (4) gained filtrate and medicated powder, sterilizing encapsulation obtains Chinese medicine composition decoction.
4. the tonsillitic Chinese medicine composition of therapeutic purulence as claimed in claim 3, is characterized in that, in step (4), ethanol amount is the 3-5 of medical material weight doubly (preferred: ethanol amount is 4 times of medical material weight).
5. the tonsillitic Chinese medicine composition of therapeutic purulence as described in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable powder, its preparation method is:
(1) get Gypsum Fibrosum, remove impurity is cleaned, and dries to smash to be placed in mortar, adds clear water and grinds to form pasty state, continues to add water and constantly stirs, topple over suspension; Repeatable operation, to the greasy shape of porphyrize, merges suspension, leaves standstill the supernatant that inclines, dries;
(2) get Testa Tritici and put into pot, moderate heat is heated to smolder, then the Ramulus Uncariae Cum Uncis cleaned, the Rhizoma Anemarrhenae, Radix Rhapontici, Rhizoma aspidistrae typicae, Radix Puerariae, Radix Cynanchi Paniculati, Herba Catharanthi Rosei, the Flos Sophorae Immaturus and Herba Schizonepetae is cut into slices, and mixes with Testa Tritici, constantly stir, it is (preferred: the time of stirring is 20-25 minute that the time is 15-30 minute; Be more preferably: the time of stirring is 23 minutes), take out, sieve remove Testa Tritici, dry in the air cool;
(3) Fructus Manglietiae fordianae and Fructus Momordicae are cleaned remove impurity, grind to form pureed, heating, with oil-Absorbing Sheets parcel, oil is removed in squeezing, until medicine does not glue, forms cake and be as the criterion;
(4) by medicine made to step (2) (3), carefully grind to form fine powder, mix with step (1) gained gypsum powder, sieve, obtain Chinese medicine composition composition powders.
6. the tonsillitic Chinese medicine composition of therapeutic purulence as claimed in claim 5, is characterized in that, in step (4), the order number of sieve is that 100-140(is preferred: the order number of sieve is 110-130; Be more preferably: the order number of sieve is 120).
7. the tonsillitic Chinese medicine composition of therapeutic purulence as described in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable pill, its preparation method is:
(1) get Gypsum Fibrosum, remove impurity is cleaned, and dries to smash to be placed in mortar, adds clear water and grinds to form pasty state, continues to add water and constantly stirs, topple over suspension; Repeatable operation, to the greasy shape of porphyrize, merges suspension, leaves standstill the supernatant that inclines, dries;
(2) get Testa Tritici and put into pot, moderate heat is heated to smolder, then the Ramulus Uncariae Cum Uncis cleaned, the Rhizoma Anemarrhenae, Radix Rhapontici, Rhizoma aspidistrae typicae, Radix Puerariae, Radix Cynanchi Paniculati, Herba Catharanthi Rosei, the Flos Sophorae Immaturus and Herba Schizonepetae is cut into slices, and mixes with Testa Tritici, constantly stir, it is (preferred: the time of stirring is 20-25 minute that the time is 15-30 minute; Be more preferably: the time of stirring is 23 minutes), take out, sieve remove Testa Tritici, dry in the air cool;
(3) Fructus Manglietiae fordianae and Fructus Momordicae are cleaned remove impurity, grind to form pureed, heating, with oil-Absorbing Sheets parcel, oil is removed in squeezing, until medicine does not glue, forms cake and be as the criterion;
(4) by step (2) (3) made medical material, carefully pulverize, mix with step (1) gained gypsum powder, cross 120 mesh sieves, add refined honey, fully with even, bar processed, one-tenth ball, packaging, obtain Chinese medicine composition pill.
8. the tonsillitic Chinese medicine composition of therapeutic purulence as claimed in claim 7, is characterized in that, the ratio of step (4) Chinese medicine powder and refined honey is that 1:1-1:1.5(is preferred: the ratio of medicated powder and refined honey is 1:1.2).
9. the tonsillitic Chinese medicine composition of therapeutic purulence as described in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable unguentum, its preparation method is:
(1) get Gypsum Fibrosum, remove impurity is cleaned, and dries to smash to be placed in mortar, adds clear water and grinds to form pasty state, continues to add water and constantly stirs, topple over suspension; Repeatable operation, to the greasy shape of porphyrize, merges suspension, leaves standstill the supernatant that inclines, dries;
(2) get Testa Tritici and put into pot, moderate heat is heated to smolder, more clean Ramulus Uncariae Cum Uncis, the Rhizoma Anemarrhenae, Radix Rhapontici, Rhizoma aspidistrae typicae, Radix Puerariae and Radix Cynanchi Paniculati are cut sheet, mixes, constantly stir with Testa Tritici, and it is (preferred: the time of stirring is 20-25 minute that the time is 15-30 minute; Be more preferably: the time of stirring is 23 minutes), take out, sieve remove Testa Tritici, dry in the air cool;
(3) by step (2) made Chinese crude drug and gypsum powder, decoct with water, big fire is heated, and adds Herba Catharanthi Rosei, the Flos Sophorae Immaturus and Herba Schizonepetae again after boiling, turns little fire and decocts 40-60 minute (preferably: little fire decocts 45-55 minute; Be more preferably: little fire decocts 50 minutes), filtered while hot obtains filtrate;
(4) Fructus Manglietiae fordianae and Fructus Momordicae are added water steaming and decocting 50-70 minute (preferably: steaming and decocting 55-65 minute; Be more preferably: steaming and decocting 60 minutes), take out and pulverize into pureed;
(5) blend step (3) (4) gains, heating under reduced pressure is concentrated into the paste that relative density is 1.22, obtains Traditional Chinese medicine composition paste.
10. the tonsillitic Chinese medicine composition of therapeutic purulence as claimed in claim 9, is characterized in that, in step (3), amount of water is that the 6-9 of medical material weight is doubly (preferred: amount of water is 7-8 times of medical material weight; Be more preferably: amount of water is 7.5 times of medical material weight).
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| CN101342328A (en) * | 2008-08-19 | 2009-01-14 | 宫兆荣 | Traditional Chinese medicine composing prescription for treating children's bacterial upper respiratory tract infection |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101342328A (en) * | 2008-08-19 | 2009-01-14 | 宫兆荣 | Traditional Chinese medicine composing prescription for treating children's bacterial upper respiratory tract infection |
Non-Patent Citations (2)
| Title |
|---|
| 曾立崑等编著: "《妇儿科疑难病的中医治疗》", 30 November 1996, 人民军医出版社 * |
| 李彬之等主编: "《现代中医奇效良方宝典（下）》", 30 September 1997, 上海科学普及出版社 * |
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