CN104435516A - Traditional Chinese medicine combination for treating liver-kidney yin deficiency type xerophthalmia - Google Patents
Traditional Chinese medicine combination for treating liver-kidney yin deficiency type xerophthalmia Download PDFInfo
- Publication number
- CN104435516A CN104435516A CN201410698573.6A CN201410698573A CN104435516A CN 104435516 A CN104435516 A CN 104435516A CN 201410698573 A CN201410698573 A CN 201410698573A CN 104435516 A CN104435516 A CN 104435516A
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- liver
- yin deficiency
- medicine composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 40
- 208000031971 Yin Deficiency Diseases 0.000 title claims abstract description 23
- 208000005494 xerophthalmia Diseases 0.000 title claims abstract description 23
- 239000002994 raw material Substances 0.000 claims abstract description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 30
- 239000000203 mixture Substances 0.000 claims description 20
- 238000002360 preparation method Methods 0.000 claims description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 239000012567 medical material Substances 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 12
- 239000007788 liquid Substances 0.000 claims description 9
- 239000008187 granular material Substances 0.000 claims description 8
- 239000000843 powder Substances 0.000 claims description 8
- 229920002472 Starch Polymers 0.000 claims description 6
- 239000002552 dosage form Substances 0.000 claims description 6
- 239000000706 filtrate Substances 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 235000019698 starch Nutrition 0.000 claims description 6
- 239000008107 starch Substances 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 239000002775 capsule Substances 0.000 claims description 3
- 239000012467 final product Substances 0.000 claims description 2
- 239000006187 pill Substances 0.000 claims description 2
- 239000006188 syrup Substances 0.000 claims description 2
- 235000020357 syrup Nutrition 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 210000004185 liver Anatomy 0.000 abstract description 28
- 210000003734 kidney Anatomy 0.000 abstract description 20
- 230000000694 effects Effects 0.000 abstract description 8
- 230000001737 promoting effect Effects 0.000 abstract description 4
- 241000759833 Cornus officinalis Species 0.000 abstract 1
- 244000075634 Cyperus rotundus Species 0.000 abstract 1
- 235000016854 Cyperus rotundus Nutrition 0.000 abstract 1
- 241000195955 Equisetum hyemale Species 0.000 abstract 1
- 240000004670 Glycyrrhiza echinata Species 0.000 abstract 1
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 abstract 1
- 235000002710 Ilex cornuta Nutrition 0.000 abstract 1
- 241001310146 Ilex cornuta Species 0.000 abstract 1
- 241000132446 Inula Species 0.000 abstract 1
- 240000000249 Morus alba Species 0.000 abstract 1
- 235000008708 Morus alba Nutrition 0.000 abstract 1
- 235000010326 Osmanthus heterophyllus Nutrition 0.000 abstract 1
- 241000405414 Rehmannia Species 0.000 abstract 1
- 206010039424 Salivary hypersecretion Diseases 0.000 abstract 1
- 229940010454 licorice Drugs 0.000 abstract 1
- 208000026451 salivation Diseases 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 description 12
- 201000010099 disease Diseases 0.000 description 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 11
- 210000001508 eye Anatomy 0.000 description 11
- 230000006870 function Effects 0.000 description 11
- 239000008280 blood Substances 0.000 description 10
- 210000004369 blood Anatomy 0.000 description 10
- 238000004043 dyeing Methods 0.000 description 8
- 230000028327 secretion Effects 0.000 description 8
- 208000003556 Dry Eye Syndromes Diseases 0.000 description 6
- 206010013774 Dry eye Diseases 0.000 description 6
- 235000009508 confectionery Nutrition 0.000 description 6
- 208000002173 dizziness Diseases 0.000 description 6
- 206010034960 Photophobia Diseases 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 230000004438 eyesight Effects 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 210000000952 spleen Anatomy 0.000 description 5
- 208000011580 syndromic disease Diseases 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 241000475481 Nebula Species 0.000 description 4
- 208000002193 Pain Diseases 0.000 description 4
- 208000009205 Tinnitus Diseases 0.000 description 4
- 210000001124 body fluid Anatomy 0.000 description 4
- 239000010839 body fluid Substances 0.000 description 4
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 4
- 230000010354 integration Effects 0.000 description 4
- 210000004072 lung Anatomy 0.000 description 4
- 230000001105 regulatory effect Effects 0.000 description 4
- 230000035807 sensation Effects 0.000 description 4
- 231100000886 tinnitus Toxicity 0.000 description 4
- 206010011224 Cough Diseases 0.000 description 3
- 208000019255 Menstrual disease Diseases 0.000 description 3
- 230000002159 abnormal effect Effects 0.000 description 3
- 239000000607 artificial tear Substances 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 210000000481 breast Anatomy 0.000 description 3
- 210000004087 cornea Anatomy 0.000 description 3
- 230000007812 deficiency Effects 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 239000003172 expectorant agent Substances 0.000 description 3
- 230000003419 expectorant effect Effects 0.000 description 3
- 229960002143 fluorescein Drugs 0.000 description 3
- 210000003127 knee Anatomy 0.000 description 3
- 230000037452 priming Effects 0.000 description 3
- 230000001502 supplementing effect Effects 0.000 description 3
- 208000004998 Abdominal Pain Diseases 0.000 description 2
- 208000002177 Cataract Diseases 0.000 description 2
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 2
- 208000005189 Embolism Diseases 0.000 description 2
- 206010015958 Eye pain Diseases 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- 208000009319 Keratoconjunctivitis Sicca Diseases 0.000 description 2
- 206010033557 Palpitations Diseases 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 208000001435 Thromboembolism Diseases 0.000 description 2
- 208000005946 Xerostomia Diseases 0.000 description 2
- 230000000172 allergic effect Effects 0.000 description 2
- 230000001174 ascending effect Effects 0.000 description 2
- 208000003464 asthenopia Diseases 0.000 description 2
- 208000010668 atopic eczema Diseases 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 210000005252 bulbus oculi Anatomy 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 229910017052 cobalt Inorganic materials 0.000 description 2
- 239000010941 cobalt Substances 0.000 description 2
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 206010013781 dry mouth Diseases 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 210000000744 eyelid Anatomy 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 230000023597 hemostasis Effects 0.000 description 2
- 230000002440 hepatic effect Effects 0.000 description 2
- 208000013403 hyperactivity Diseases 0.000 description 2
- 206010029410 night sweats Diseases 0.000 description 2
- 230000036565 night sweats Effects 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000003014 reinforcing effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 230000004206 stomach function Effects 0.000 description 2
- 210000001913 submandibular gland Anatomy 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 230000035922 thirst Effects 0.000 description 2
- 206010000077 Abdominal mass Diseases 0.000 description 1
- 201000000736 Amenorrhea Diseases 0.000 description 1
- 206010001928 Amenorrhoea Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 238000012935 Averaging Methods 0.000 description 1
- 201000004569 Blindness Diseases 0.000 description 1
- 208000002881 Colic Diseases 0.000 description 1
- 101100117236 Drosophila melanogaster speck gene Proteins 0.000 description 1
- 208000005171 Dysmenorrhea Diseases 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 208000008967 Enuresis Diseases 0.000 description 1
- 241000909851 Epiphora Species 0.000 description 1
- 206010017533 Fungal infection Diseases 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 208000010412 Glaucoma Diseases 0.000 description 1
- 206010054787 Haemorrhoidal haemorrhage Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 206010020565 Hyperaemia Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 208000004044 Hypesthesia Diseases 0.000 description 1
- 206010062016 Immunosuppression Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 206010023635 Lacrimal passage granuloma Diseases 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 208000001140 Night Blindness Diseases 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 208000028017 Psychotic disease Diseases 0.000 description 1
- 206010037508 Punctate keratitis Diseases 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 208000032023 Signs and Symptoms Diseases 0.000 description 1
- 206010064996 Ulcerative keratitis Diseases 0.000 description 1
- 208000012886 Vertigo Diseases 0.000 description 1
- 206010047513 Vision blurred Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 231100000540 amenorrhea Toxicity 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 230000000721 bacterilogical effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 208000010217 blepharitis Diseases 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 201000007717 corneal ulcer Diseases 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 210000003560 epithelium corneal Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 239000003889 eye drop Substances 0.000 description 1
- 201000008996 filamentary keratitis Diseases 0.000 description 1
- 229940020947 fluorescein sodium Drugs 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 230000033687 granuloma formation Effects 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 230000002607 hemopoietic effect Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 238000001794 hormone therapy Methods 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 208000034783 hypoesthesia Diseases 0.000 description 1
- 230000001506 immunosuppresive effect Effects 0.000 description 1
- 229960003444 immunosuppressant agent Drugs 0.000 description 1
- 230000001861 immunosuppressant effect Effects 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000010832 independent-sample T-test Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 206010023332 keratitis Diseases 0.000 description 1
- 210000000629 knee joint Anatomy 0.000 description 1
- 208000016747 lacrimal apparatus disease Diseases 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 210000004914 menses Anatomy 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000007427 paired t-test Methods 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 208000037920 primary disease Diseases 0.000 description 1
- 208000008128 pulmonary tuberculosis Diseases 0.000 description 1
- 201000003827 punctate epithelial keratoconjunctivitis Diseases 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/40—Cornaceae (Dogwood family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/486—Millettia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/89—Cyperaceae (Sedge family)
- A61K36/8905—Cyperus (flatsedge)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Marine Sciences & Fisheries (AREA)
- Zoology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a traditional Chinese medicine combination for treating liver-kidney yin deficiency type xerophthalmia, and belongs to the field of traditional Chinese medicine. The combination is prepared from the following raw materials: concha haliotidis, cyperus rotundus, scouring rush, mulberry leaf, prepared rehmannia root, cornus officinalis, inula herb, Chinese holly leaf, prepared licorice and caulis spatholobi. The traditional Chinese medicine combination can be prepared into various does types, has the efficiencies of nourishing liver and kidney, promoting salivation and moistening dryness, and has obvious treatment effect on the liver-kidney yin deficiency type xerophthalmia.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine composition for the treatment of liver-kidney yin deficiency xerophthalmia, belong to tcm field.
Background technology
Xerophthalmia (dry eye syndrome) is also known as angle conjunctival xerosis (keratoconjunctivitis sicca, KCS), it is a kind of common eye surface diseases, refer to the tear quality and quantity that caused by a variety of causes or the abnormal tear film caused of kinetics is unstable and ocular surface injury and cause the general name of one of ophthalmic uncomfortable large class disease, modal symptom is asthenopia, foreign body sensation, sensation of dryness, other symptoms have burn feeling, ophthalmic bloated sense, ophthalmalgia, photophobia and are envious, severe patient can develop into filamentary keratitis, even corneal ulcer.
Xerophthalmia belongs to " oligodacrya " category in Chinese medicine." silver-colored Nereid is micro-" points out " tears being related to the liver ", "Nei Jing" cloud: " kidney person water is dirty, main body fluid." " body fluid of the vital organs of the human body is use up and oozed in order." motherland's medical science thinks that order pearl is moistened; not only rely on the mediation of irritability, the abundant of liver blood, and depend on kidney qi fill and, the supplementing nutrition of kidney essense, if Liver and kidney imbalance; blood and essence asthenia; hyperactivity of fire caused by deficiency of YIN, hyperactivity of deficient fire, burn Tianjin consumption liquid; then tear the source of vital function is not enough; order loses making moist of body fluid, and causes the generation of xerophthalmia, and its main pathogenesis is the hepatic and renal YIN deficiency.Disease is seen: eye is dry and astringent not well, and binocular frequently blinks, photophobia photophobia, white of the eye are indistinctly light red, and after watching for a long time, then all diseases are increased the weight of, and black eyeball can have choice refreshments punctate keratitis, can accompany the few Tianjin of xerostomia, soreness of the waist and knees, dizziness and tinnitus, night sleep dreaminess, red tongue, thin fur, thready pulse.
Current topmost Therapeutic Method is that artificial tears's alternative medicine, local immunosuppression agent and hormone therapy, puncta thromboembolism and puncta are closed, tear membrane reconstitution and Autotransplantation of submandibular gland etc.Artificial tears's not only economy but also practical, side effect is relatively less, widely uses clinically.But artificial tears is once stop using, and symptom occurs at once.Puncta thromboembolism likely infects or causes lacrimal passage Granuloma formation to need to take out, and puncta is closed may cause excessive tear again.Can there is eyelid swelled in immunosuppressant, eye hyperemia and pain.Life-time service hormone can bring out glaucoma and complicated cataract, and Autotransplantation of submandibular gland belongs to invasive surgery, and patient also not easily accepts, and clinical practice is limited.
Summary of the invention
An object of the present invention is to provide a kind of Chinese medicine composition for the treatment of liver-kidney yin deficiency xerophthalmia, said composition have nourishing the liver and kidney, effect of moisturizing of promoting the production of body fluid, the therapeutic effect for liver-kidney yin deficiency xerophthalmia is remarkable.
In order to achieve the above object, the present invention adopts following technical scheme: a kind of Chinese medicine composition for the treatment of liver-kidney yin deficiency xerophthalmia, it is characterized in that being made up of following Medicinal crude drug: Concha Haliotidis, Rhizoma Cyperi, Herba Equiseti Hiemalis, Folium Mori, Radix Rehmanniae Preparata, Fructus Corni, Herba Inulae, Folium Ilicis Cornutae, Radix Glycyrrhizae Preparata, Caulis Spatholobi.
The concrete pharmacological research present situation of each component of the present invention is as follows: Concha Haliotidis: salty, cold.Return Liver Channel.Function cures mainly: suppressing the hyperactive liver and subsiding YANG, liver heat removing and eyesight improving.Dizzy for having a headache, cataract, blurring of vision, optic atrohic blindness nyctalopia.
Rhizoma Cyperi: pungent, micro-hardship, micro-sweet, flat.Return liver, spleen, tri-jiao channel.Function cures mainly: promoting QI circulation for relieving depression, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.
Herba Equiseti Hiemalis: sweet, bitter; Flat.Return lung; Liver; Gallbladder meridian.Function cures mainly: wind and heat dispersing; Cooling blood for hemostasis; Improving acuity of vision and removing nebula.The hot conjunctival congestion of main air; The raw nebula of order; Epiphora induced by wind; Discharging fresh blood stool; Hemorrhoidal bleeding; Dysentery; Married woman's metrorrhagia; Proctoptosis.
Folium Mori: sweet, bitter, cold.Return lung, Liver Channel.Function cures mainly: dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, liver heat removing and eyesight improving.For anemopyretic cold, lung-heat type cough, dizziness headache, conjunctival congestion is dim-sighted.
Radix Rehmanniae Preparata: sweet, tepor.Return liver, kidney channel.Function cures mainly: nourishing YIN and supplementing blood, and beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair.
Fructus Corni: sour, puckery, tepor.Return liver, kidney channel.Function cures mainly: liver and kidney tonifying, essence astringing and desertion stemming.For vertigo and tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, profuse sweating is collapsed.Interior-heat is quenched one's thirst.
Herba Inulae: bitter, pungent, salty, temperature.Return lung, large intestine channel.Function cures mainly: sending down the abnormal ascending QI, expectorant, row water.For cough due to wind and cold, phlegm retention stores knot, and expectorant stops up QI rising in reverse order, chest and diaphragm feeling of fullness, dyspnea and cough with excessive sputum; External treatment furuncle swelling toxin.
Folium Ilicis Cornutae: bitter, cool.Return liver, kidney channel.Function cures mainly: clearing away heat and nourishing YIN, suppressing the hyperactive liver, kidney tonifying.For pulmonary tuberculosis spitting of blood, osteopyrexia and fever, has a dizzy spell; Hypertension.
Caulis Spatholobi: bitter, sweet, temperature.Return liver, kidney channel.Function cures mainly: enrich blood, and invigorates blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia.
Radix Glycyrrhizae Preparata: sweet is flat.GUIXIN, lung, spleen, stomach warp.Function cures mainly: spleen reinforcing stomach function regulating, Yiqi and vein recovery.For weakness of the spleen and stomach, fatigue and weakness, severe palpitation, irregularly intermittent and regularly intermittent pulse.
The consumption of the composition of the Chinese medicine composition for the treatment of liver-kidney yin deficiency xerophthalmia provided by the invention is that inventor's process gropes to sum up to get for a long time in a large number, and each component all has good curative effect in following weight parts: Concha Haliotidis 17-23 part, Rhizoma Cyperi 6-9 part, Herba Equiseti Hiemalis 6-9 part, Folium Mori 8-15 part, Radix Rehmanniae Preparata 20-25 part, Fructus Corni 16-21 part, Herba Inulae 5-8 part, Folium Ilicis Cornutae 15-20 part, Radix Glycyrrhizae Preparata 5-9 part, Caulis Spatholobi 11-16 part.
In side, Radix Rehmanniae Preparata Wen Xinneng mends, and Fructus Corni is sour and astringent can be received, the merit that nourishing YIN and supplementing blood played altogether by two medicines, liver and kidney tonifying, beneficial essence fill out marrow, can complementary energy puckery, treating both the principal and secondary aspects of a disease, makes tear biochemistry active.Folium Ilicis Cornutae bitter in the mouth is cool in nature, clearing away heat and nourishing YIN, suppressing the hyperactive liver kidney tonifying, with Radix Rehmanniae Preparata 5 use, mends and is harmonious clearly, treating both the principal and the secondary aspects of a disease at the same time.Caulis Spatholobi promoting blood circulation to remove obstruction in the collateral, priming is descending; Folium Mori dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, liver heat removing and eyesight improving, priming is up; Rhizoma Cyperi depressed liver-energy dispersing and QI regulating, three medicines totally 5, priming enters disease institute.Herba Equiseti Hiemalis's wind and heat dispersing, cooling blood for hemostasis and Folium Mori share, and strengthen the merit of wind-dispelling heat-dissipating, improving acuity of vision and removing nebula.The expectorant of Herba Inulae sending down the abnormal ascending QI, Radix Glycyrrhizae Preparata spleen reinforcing stomach function regulating, in case Radix Rehmanniae Preparata, Fructus Corni nourishing the liver and kidney is greasy.Full side combined into energy complementary energy clear, mend be harmonious clearly, invigorating middle warmer have loose, loose and only, grow and oiliness, treating both the principal and secondary aspects of a disease, for the treatment of liver-kidney yin deficiency xerophthalmia.
Inventor with we to the therapeutic effect for the treatment of liver-kidney yin deficiency xerophthalmia for condition, to carry out preferably to we, preferably, the Chinese medicine composition for the treatment of liver-kidney yin deficiency xerophthalmia described above, it is made up of the medicinal raw material of following weight portion: Concha Haliotidis 19 parts, Rhizoma Cyperi 8 parts, Herba Equiseti Hiemalis 7 parts, 12 parts, Folium Mori, Radix Rehmanniae Preparata 23 parts, Fructus Corni 18 parts, Herba Inulae 6 parts, Folium Ilicis Cornutae 17 parts, Radix Glycyrrhizae Preparata 8 parts, Caulis Spatholobi 12 parts.
Another object of the present invention is to provide a kind of method preparing Chinese medicine composition described above.
A kind of method preparing the Chinese medicine composition for the treatment of liver-kidney yin deficiency xerophthalmia of the present invention, it is characterized in that comprising the following steps: measure Concha Haliotidis by prescription, add water as the 6-10 times amount of whole medical material weight, decoct 10-30 minute, add Rhizoma Cyperi, Herba Equiseti Hiemalis, Folium Mori, Radix Rehmanniae Preparata, Fructus Corni, Herba Inulae, Folium Ilicis Cornutae, Radix Glycyrrhizae Preparata, Caulis Spatholobi decoction 0.5-1.0 hour again, leach decocting liquid; Filtering residue adds water as the 4-6 times amount of medical material weight again, decocts 1-1.5 hour, collecting decoction, when being evaporated to 60 DEG C, relative density is 1.05-1.13, adds 95% (V/V) ethanol and makes alcohol content reach 55-70% (V/V), stirs, hold over night, filters, and filtrate reduced in volume reclaims ethanol, be condensed into thick paste, add starch, mixing, dry, be ground into fine powder, obtain final product.
In order to express pharmaceutical composition of the present invention better, Chinese medicine composition of the present invention can add various customary adjuvant required when preparing different dosage form, such as disintegrating agent, lubricant, adhesive etc. make the conventional peroral dosage form of any one with the Chinese medicine preparation preparation method of routine, such as, the preparation such as powder, pill, granule, oral liquid, syrup, tablet, capsule.
Preferably, Chinese medicine composition of the present invention conveniently preparation technology be prepared into granule.
Usage and consumption: take granule, once a bag, day takes secondary, within two weeks, is a course for the treatment of.
The present invention is further illustrated below by way of clinical trial
1. general clinical data: this research case is in December, 2012 in the June ,-2013 of the syndrome of yin deficiency of liver and kidney dry eye patients at my institute's ophthalmology Office visits, and totally 80 examples, employing random digits table is divided into treatment group and matched group at random.Two groups of no significant difference on age, the course of disease, Sex distribution (P > 0.05).
2. diagnostic criteria: " the disease of tcm Standardization of diagnosis and curative effect " promulgated with reference to the Chinese State Administration of Traditional Chinese Medicines: (1) eye is dry and astringent, mill pain, photophobia, can be dry with mouth and nose; (2) jade-like stone profit gloss is lost in the drying of order pearl, and white of the eye is micro-red, the raw nebula of black eyeball, and a lot of secretion in the eye is sticky; (3) lacrimal secretion quantitative determination, repeatedly Schirmer method is less than 10mm/5min, and corneal fluorescein dye test is positive.Tcm diagnosis and differentiation of symptoms and signs for classification of syndrome are according to above-mentioned clinical manifestation and have dizziness and tinnitus, night sweat, xerostomia, soreness of the waist and knees, the few tongue of red tongue, thready and rapid pulse concurrently, and dialectical is syndrome of yin deficiency of liver and kidney.
3. inclusive criteria: meet xerophthalmia clinical criteria, and dialectical be syndrome of yin deficiency of liver and kidney; Do not accept additive method treatment and be ready to coordinate this method therapist; Age is between 20 ~ 75 years old; Signature Informed Consent Form.
4. exclusion standard: gestation or women breast-feeding their children; Allergic constitution or those who are allergic to this drug; With cornea bacteriological infection or fungal infections and cerneal dystrophy person; The vaporized strong xerophthalmia such as blepharitis, exception of twinkling, eyelid malposition; Be associated with severe primary disease and the psychotics such as cardiovascular, cerebrovascular, liver, kidney and hemopoietic system; Age is less than 20 years old or is greater than 75 years old person.
1.5 subjective symptom integrations: by common symptoms: eye sensation of dryness, foreign body sensation, eyestrain, burn feeling, ophthalmic bloated sense, ophthalmalgia sense, photophobia, furious etc. totally 8, be divided into without, light (accidentally), in (often), weight (continuing) degree, corresponding score 0 ~ 3 point respectively, adopts symptom scores change before and after the treatment of questionnaire survey Method compare.
1.6 observation index
1.6.1 basic Schimer's test: observe 1 time weekly, surveys 3 times repeatedly, and averaging, it is wet long to be designated as filter paper.Being less than 5mm diagnosable is adacrya; The suspicious secretion of 6 ~ 10mm reduces, and it is normal for being greater than 10mm.
1.6.2 breakup time of tear film: after fluorescein sodium corneal dyeing, advises patient to blink, then watches front attentively, under slit lamp, observes, open eyes there is the 1st black speck tear film defect to cornea from last 1 time after twinkling with cobalt blue optical filter, calculate rupture time.
1.6.3 corneal fluorescein dyeing: observe corneal epithelium under slit lamp cobalt blue light and dye situation, cornea is divided into 4 quadrants, regulation dye-free is 0 point, have dyeing then to divide gently, in, weigh 3 grades, 0 ~ 3 point, each quadrant, totally 0 ~ 12 point.
1.7 Therapeutic Method: treatment group takes Chinese medicine granules prepared by the embodiment of the present invention 1, and once a bag, day takes secondary; Matched group local uses the sweet eye drop of hydroxyl sugar (H20140263, U.S.'s Ai Erkang eye pharmaceutical factory produces), 3 ~ 6 times/day, drips eyes; All treat after 2 months for two groups and carry out efficacy evaluation.
1.8 curative effect determinate standards: the industry standard " Chinese medical disease Standardization of diagnosis and curative effect " of promulgating with reference to State Administration of Traditional Chinese Medicine is formulated: cure: transference cure, corneal dyeing disappears, and Schimer's test repeatedly measures and is greater than 10mm/5min; Take a turn for the better: symptom alleviates, corneal dyeing reduces, and Schimer's test repeatedly measures lacrimal secretion to be increased to some extent; Do not heal: symptom is without improvement, and corneal dyeing is unchanged or increase, and Schimer's test repeatedly measures lacrimal secretion not to be increased.
1.9 statistical methods: adopt SPSS16.0 software to analyze, measurement data with
represent, between group, compare employing two independent samples t test, compare in group with paired t-test, represent that difference has statistical significance with P < 0.05.
2.0 result
2.0.1 the comparison of two groups of subjective symptom integrations: after treatment, two groups of subjective symptom integrations all have reduction before comparatively treating, and difference has statistical significance (P<0.01).Compare between two groups of groups after treatment, treatment group is better than matched group, and difference has statistical significance (P<0.05), in table 1.
The comparison of table 1 liang group subjective symptom integration, point
| Group | Number of cases | Before treatment | After treatment |
| Treatment group | 40 | 13.58±2.16 | 5.16±1.98**# |
| Matched group | 40 | 13.47±2.33 | 9.43±2.45** |
Compare with before treatment, * * P < 0.01; Compare with after treatment of control group, #P < 0.05.
2.0.2 the comparison of two groups of objective indicators: after treatment, treatment group can improve lacrimal secretion, prolongation breakup time of tear film, the reduction corneal dyeing score value of dry eye patients, has statistical significance (P<0.05) with comparing difference before treatment.Matched group is in raising lacrimal secretion, prolongation breakup time of tear film, and comparing difference not statistically significant (P>0.05) front with treatment, in table 2.
The change of table 2 liang group syndrome of yin deficiency of liver and kidney dry eye patients treatment fore-and-aft observing index
Compare with before treatment, * P < 0.01.
2.0.3 two groups of Clinical efficacy comparisons: in table 3.Total effective rate treatment group is 85.0%, and matched group is 60.0%; Two groups are compared, and difference has significant (P < 0.05).
Table 3 liang group Clinical efficacy comparison, example
Brief summary: as can be seen here, after treatment group patient uses traditional Chinese medicine composition for treating of the present invention, lacrimal secretion significantly increases before all comparatively treating, and breakup time of tear film all comparatively treats front significant prolongation, and patient's malaise symptoms disappears, and corneal fluorescein dyeing score value significantly reduces.Therefore, present invention also offers a kind of pharmaceutical applications, that is: the application of said medicine preparation in the medicine of preparation treatment liver-kidney yin deficiency xerophthalmia.
The present invention compared with prior art has following beneficial effect:
1. the raw materials used medical material of the present invention can be bought from shop of Chinese medicines and obtain, and raw material is easy to get;
2. Chinese medicine composition of the present invention is high for the treated effect of liver-kidney yin deficiency xerophthalmia;
3. pharmaceutical composition of the present invention be regular dosage form take, easy to carry, can preserve for a long time, avoid long-term taking Chinese medicine decoction and to boil medicine trouble, patient takes the shortcoming of compliance difference.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.
Embodiment 1
Prescription: take each raw material of the present invention by following weight portion: Concha Haliotidis 19 parts, Rhizoma Cyperi 8 parts, Herba Equiseti Hiemalis 7 parts, 12 parts, Folium Mori, Radix Rehmanniae Preparata 23 parts, Fructus Corni 18 parts, Herba Inulae 6 parts, Folium Ilicis Cornutae 17 parts, Radix Glycyrrhizae Preparata 8 parts, Caulis Spatholobi 12 parts.
Preparation method: measure Concha Haliotidis by prescription, adds water as 6 times amount of whole medical material weight, decocts 10 minutes, then add Rhizoma Cyperi, Herba Equiseti Hiemalis, Folium Mori, Radix Rehmanniae Preparata, Fructus Corni, Herba Inulae, Folium Ilicis Cornutae, Radix Glycyrrhizae Preparata, Caulis Spatholobi decoct 0.5 hour, leaches decocting liquid; Filtering residue adds water as 4 times amount of medical material weight again, decocts 1 hour, collecting decoction, when being evaporated to 60 DEG C, relative density is 1.06, adds 95% (V/V) ethanol and makes alcohol content reach 60% (V/V), stirs, hold over night, filters, and filtrate reduced in volume reclaims ethanol, be condensed into thick paste, add starch, mixing, dry, be ground into fine powder, be prepared into granule 20 parts of bags according to Chinese medicine preparation common process.
Embodiment 2
Prescription: take each raw material of the present invention by following weight portion: Concha Haliotidis 17 parts, Rhizoma Cyperi 6 parts, Herba Equiseti Hiemalis 6 parts, 8 parts, Folium Mori, Radix Rehmanniae Preparata 20 parts, Fructus Corni 16 parts, Herba Inulae 5 parts, Folium Ilicis Cornutae 15 parts, Radix Glycyrrhizae Preparata 5 parts, Caulis Spatholobi 11 parts.
Preparation method: measure Concha Haliotidis by prescription, adds water as 8 times amount of whole medical material weight, decocts 20 minutes, then add Rhizoma Cyperi, Herba Equiseti Hiemalis, Folium Mori, Radix Rehmanniae Preparata, Fructus Corni, Herba Inulae, Folium Ilicis Cornutae, Radix Glycyrrhizae Preparata, Caulis Spatholobi decoct 1.0 hours, leaches decocting liquid; Filtering residue adds water as 5 times amount of medical material weight again, decocts 1.5 hours, collecting decoction, when being evaporated to 60 DEG C, relative density is 1.11, adds 95% (V/V) ethanol and makes alcohol content reach 70% (V/V), stirs, hold over night, filters, and filtrate reduced in volume reclaims ethanol, be condensed into thick paste, add starch, mixing, dry, be ground into fine powder, be prepared into granule according to Chinese medicine preparation common process.
Embodiment 3
Prescription: take each raw material of the present invention by following weight portion: Concha Haliotidis 23 parts, Rhizoma Cyperi 9 parts, Herba Equiseti Hiemalis 9 parts, 15 parts, Folium Mori, Radix Rehmanniae Preparata 25 parts, Fructus Corni 21 parts, Herba Inulae 8 parts, Folium Ilicis Cornutae 20 parts, Radix Glycyrrhizae Preparata 9 parts, Caulis Spatholobi 16 parts.
Preparation method: measure Concha Haliotidis by prescription, adds water as 10 times amount of whole medical material weight, decocts 30 minutes, then add Rhizoma Cyperi, Herba Equiseti Hiemalis, Folium Mori, Radix Rehmanniae Preparata, Fructus Corni, Herba Inulae, Folium Ilicis Cornutae, Radix Glycyrrhizae Preparata, Caulis Spatholobi decoct 0.5 hour, leaches decocting liquid; Filtering residue adds water as 6 times amount of medical material weight again, decocts 1 hour, collecting decoction, when being evaporated to 60 DEG C, relative density is 1.10, adds 95% (V/V) ethanol and makes alcohol content reach 65% (V/V), stirs, hold over night, filters, and filtrate reduced in volume reclaims ethanol, be condensed into thick paste, add starch, mixing, dry, be ground into fine powder, be prepared into granule according to Chinese medicine preparation common process.
Embodiment 4
Prescription: take each raw material of the present invention by following weight portion: Concha Haliotidis 17 parts, Rhizoma Cyperi 9 parts, Herba Equiseti Hiemalis 8 parts, 10 parts, Folium Mori, Radix Rehmanniae Preparata 22 parts, Fructus Corni 18 parts, Herba Inulae 8 parts, Folium Ilicis Cornutae 15 parts, Radix Glycyrrhizae Preparata 5 parts, Caulis Spatholobi 11 parts.
Preparation method: the operation with reference to embodiment 1 is carried out.
Embodiment 5
Prescription: take each raw material of the present invention by following weight portion: Concha Haliotidis 18 parts, Rhizoma Cyperi 8 parts, Herba Equiseti Hiemalis 7 parts, 12 parts, Folium Mori, Radix Rehmanniae Preparata 22 parts, Fructus Corni 18 parts, Herba Inulae 6 parts, Folium Ilicis Cornutae 20 parts, Radix Glycyrrhizae Preparata 6 parts, Caulis Spatholobi 13 parts.
Preparation method: the operation with reference to embodiment 1 is carried out.
Concha Haliotidis 17-23 part, Rhizoma Cyperi 6-9 part, Herba Equiseti Hiemalis 6-9 part, Folium Mori 8-15 part, Radix Rehmanniae Preparata 20-25 part, Fructus Corni 16-21 part, Herba Inulae 5-8 part, Folium Ilicis Cornutae 15-20 part, Radix Glycyrrhizae Preparata 5-9 part, Caulis Spatholobi 11-16 part.
Embodiment 6
Prescription: take each raw material of the present invention by following weight portion: Concha Haliotidis 19 parts, Rhizoma Cyperi 7 parts, Herba Equiseti Hiemalis 7 parts, 12 parts, Folium Mori, Radix Rehmanniae Preparata 23 parts, Fructus Corni 20 parts, Herba Inulae 6 parts, Folium Ilicis Cornutae 15 parts, Radix Glycyrrhizae Preparata 7 parts, Caulis Spatholobi 14 parts.
Preparation method: measure Concha Haliotidis by prescription, adds water as 8 times amount of whole medical material weight, decocts 20 minutes, then add Rhizoma Cyperi, Herba Equiseti Hiemalis, Folium Mori, Radix Rehmanniae Preparata, Fructus Corni, Herba Inulae, Folium Ilicis Cornutae, Radix Glycyrrhizae Preparata, Caulis Spatholobi decoct 0.5 hour, leaches decocting liquid; Filtering residue adds water as 5 times amount of medical material weight again, decocts 1 hour, collecting decoction, when being evaporated to 60 DEG C, relative density is 1.08, adds 95% (V/V) ethanol and makes alcohol content reach 50% (V/V), stirs, hold over night, filters, and filtrate reduced in volume reclaims ethanol, be condensed into thick paste, add starch, mixing, dry, be ground into fine powder, be prepared into capsule according to Chinese medicine preparation common process.
Claims (7)
1. treat a Chinese medicine composition for liver-kidney yin deficiency xerophthalmia, it is characterized in that it is made up of the medicinal raw material of following weight portion: Concha Haliotidis 17-23 part, Rhizoma Cyperi 6-9 part, Herba Equiseti Hiemalis 6-9 part, Folium Mori 8-15 part, Radix Rehmanniae Preparata 20-25 part, Fructus Corni 16-21 part, Herba Inulae 5-8 part, Folium Ilicis Cornutae 15-20 part, Radix Glycyrrhizae Preparata 5-9 part, Caulis Spatholobi 11-16 part.
2. Chinese medicine composition as claimed in claim 1, is characterized in that it is made up of the medicinal raw material of following weight portion: Concha Haliotidis 19 parts, Rhizoma Cyperi 8 parts, Herba Equiseti Hiemalis 7 parts, 12 parts, Folium Mori, Radix Rehmanniae Preparata 23 parts, Fructus Corni 18 parts, Herba Inulae 6 parts, Folium Ilicis Cornutae 17 parts, Radix Glycyrrhizae Preparata 8 parts, Caulis Spatholobi 12 parts.
3. prepare the method for Chinese medicine composition as claimed in claim 1 or 2 for one kind, it is characterized in that comprising the following steps: measure Concha Haliotidis by prescription, add water as the 6-10 times amount of whole medical material weight, decoct 10-30 minute, add Rhizoma Cyperi, Herba Equiseti Hiemalis, Folium Mori, Radix Rehmanniae Preparata, Fructus Corni, Herba Inulae, Folium Ilicis Cornutae, Radix Glycyrrhizae Preparata, Caulis Spatholobi decoction 0.5-1.0 hour again, leach decocting liquid; Filtering residue adds water as the 4-6 times amount of medical material weight again, decocts 1-1.5 hour, collecting decoction, when being evaporated to 60 DEG C, relative density is 1.05-1.13, adds 95% (V/V) ethanol and makes alcohol content reach 55-70% (V/V), stirs, hold over night, filters, and filtrate reduced in volume reclaims ethanol, be condensed into thick paste, add starch, mixing, dry, be ground into fine powder, obtain final product.
4. preparation method as claimed in claim 3, is characterized in that this Chinese medicine composition makes peroral dosage form.
5. preparation method as claimed in claim 4, is characterized in that described peroral dosage form is powder, pill, granule, oral liquid, syrup, tablet or capsule.
6. preparation method as claimed in claim 5, is characterized in that described peroral dosage form preferred particulates agent agent.
7. the application of Chinese medicine composition as claimed in claim 1 or 2 in the medicine of preparation treatment liver-kidney yin deficiency xerophthalmia.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410698573.6A CN104435516A (en) | 2014-11-27 | 2014-11-27 | Traditional Chinese medicine combination for treating liver-kidney yin deficiency type xerophthalmia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410698573.6A CN104435516A (en) | 2014-11-27 | 2014-11-27 | Traditional Chinese medicine combination for treating liver-kidney yin deficiency type xerophthalmia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104435516A true CN104435516A (en) | 2015-03-25 |
Family
ID=52882777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410698573.6A Pending CN104435516A (en) | 2014-11-27 | 2014-11-27 | Traditional Chinese medicine combination for treating liver-kidney yin deficiency type xerophthalmia |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104435516A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105477348A (en) * | 2016-01-04 | 2016-04-13 | 田振欣 | Traditional Chinese medicine for treating liver-kidney yin deficiency type xerophthalmia |
| CN106491945A (en) * | 2016-11-16 | 2017-03-15 | 张晓会 | A kind of treat traditional Chinese medicine fumigating steaming liquid that the dry and astringent photophobia of itching of eye is shed tears and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101926890A (en) * | 2010-08-17 | 2010-12-29 | 张洪星 | Medicament for treating xerophthalmia |
| CN103285363A (en) * | 2013-06-26 | 2013-09-11 | 王次霞 | Drug for treating xerophthalmia with cervical spondylosis |
-
2014
- 2014-11-27 CN CN201410698573.6A patent/CN104435516A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101926890A (en) * | 2010-08-17 | 2010-12-29 | 张洪星 | Medicament for treating xerophthalmia |
| CN103285363A (en) * | 2013-06-26 | 2013-09-11 | 王次霞 | Drug for treating xerophthalmia with cervical spondylosis |
Non-Patent Citations (1)
| Title |
|---|
| 王学珍: "中西医结合治疗肝肾阴虚型干眼症的疗效观察", 《国际眼科杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105477348A (en) * | 2016-01-04 | 2016-04-13 | 田振欣 | Traditional Chinese medicine for treating liver-kidney yin deficiency type xerophthalmia |
| CN106491945A (en) * | 2016-11-16 | 2017-03-15 | 张晓会 | A kind of treat traditional Chinese medicine fumigating steaming liquid that the dry and astringent photophobia of itching of eye is shed tears and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103656290B (en) | Medicine for treating optic atrophy and preparation method of medicine | |
| CN102698079B (en) | Medicine composition for treating xerophthalmia and preparation method and application thereof | |
| CN103393915B (en) | Chinese medicinal preparation for treating xerophthalmia | |
| CN103007014B (en) | Traditional Chinese medicine composition used for treating xerophthalmia and preparation method thereof | |
| CN104435516A (en) | Traditional Chinese medicine combination for treating liver-kidney yin deficiency type xerophthalmia | |
| CN104436040A (en) | Medicine for treating xerophthalmia | |
| CN104324222A (en) | Traditional Chinese medicine preparation for treating Qi and Yin deficiency type dry eye syndromes | |
| CN111437317A (en) | A Chinese medicinal composition with immunity enhancing effect | |
| CN105168590A (en) | Traditional Chinese medicine for treating xerophthalmia | |
| CN103877424B (en) | A kind of Chinese medicine liquid medicine and preparation method for the treatment of trachoma | |
| CN102920911B (en) | Traditional Chinese medicine for treating keratoconjunctivitis sicca and preparation method thereof | |
| CN106362089A (en) | External medicine for treating eye diseases | |
| CN105213887A (en) | One is used for the treatment of glaucomatous Chinese medicine composition | |
| CN104352794A (en) | Traditional Chinese medicine preparation for treating lung yin deficiency type xerophthalmia | |
| CN105125735A (en) | Traditional Chinese medicinal composition for treating xerophthalmia | |
| CN112336838A (en) | Traditional Chinese medicine formula eye drop for treating xerophthalmia and preparation method thereof | |
| CN104127578B (en) | Traditional Chinese medicine composition for treating acute or chronic rhinitis and preparation method thereof | |
| CN106668240A (en) | Pharmaceutical composition for treating vitreous opacity | |
| CN106421198A (en) | Novel application of Qiming (fruit of Chinese wolfberry and semen cassiae) traditional Chinese medicinal composition | |
| CN105288372A (en) | Pharmaceutical preparation for curing primary dysmenorrhea accompanied by acne | |
| CN105477545A (en) | Medicine for treating cerebral thrombosis and preparation method of medicine | |
| CN105194521A (en) | Traditional Chinese medicine oral liquid for relieving premature ovarian failure and preparation method thereof | |
| CN1331500C (en) | Chinese medicine for treating ocular funcus hemorrhage caused by yin deficiency, liver sthenia, heat impairing collaterals and preparation method | |
| CN104398847A (en) | Medicinal decoction for treating vitreous opacities and fundus hemorrhage and preparation method | |
| CN105560645A (en) | Traditional Chinese medicine preparation for treating amblyopia and preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150325 |
|
| RJ01 | Rejection of invention patent application after publication |