CN104435295A - Medicine composition containing active ingredients of jujube kernel tranquilizing pellets - Google Patents
Medicine composition containing active ingredients of jujube kernel tranquilizing pellets Download PDFInfo
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- CN104435295A CN104435295A CN201410615938.4A CN201410615938A CN104435295A CN 104435295 A CN104435295 A CN 104435295A CN 201410615938 A CN201410615938 A CN 201410615938A CN 104435295 A CN104435295 A CN 104435295A
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- extract
- fructus schisandrae
- schisandrae chinensis
- pharmaceutical composition
- ziziphi spinosae
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- 239000003814 drug Substances 0.000 title claims abstract description 22
- 239000000203 mixture Substances 0.000 title claims abstract description 11
- 229940079593 drug Drugs 0.000 title claims description 12
- 230000002936 tranquilizing effect Effects 0.000 title abstract description 6
- 240000008866 Ziziphus nummularia Species 0.000 title abstract 2
- 239000004480 active ingredient Substances 0.000 title abstract 2
- 239000008188 pellet Substances 0.000 title abstract 2
- 239000000284 extract Substances 0.000 claims abstract description 43
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 31
- 239000011347 resin Substances 0.000 claims abstract description 15
- 229920005989 resin Polymers 0.000 claims abstract description 15
- 229930013686 lignan Natural products 0.000 claims abstract description 11
- 235000009408 lignans Nutrition 0.000 claims abstract description 11
- 150000005692 lignans Chemical class 0.000 claims abstract description 11
- 238000001179 sorption measurement Methods 0.000 claims abstract description 10
- 238000000194 supercritical-fluid extraction Methods 0.000 claims abstract description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 33
- 210000000582 semen Anatomy 0.000 claims description 32
- 239000008194 pharmaceutical composition Substances 0.000 claims description 25
- 238000010828 elution Methods 0.000 claims description 22
- 239000000843 powder Substances 0.000 claims description 20
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims description 16
- 239000007788 liquid Substances 0.000 claims description 14
- 230000001624 sedative effect Effects 0.000 claims description 14
- 241001247821 Ziziphus Species 0.000 claims description 13
- 239000008187 granular material Substances 0.000 claims description 13
- 239000000932 sedative agent Substances 0.000 claims description 13
- 238000002360 preparation method Methods 0.000 claims description 12
- WTPPRJKFRFIQKT-UHFFFAOYSA-N 1,6-dimethyl-8,9-dihydronaphtho[1,2-g][1]benzofuran-10,11-dione;1-methyl-6-methylidene-8,9-dihydro-7h-naphtho[1,2-g][1]benzofuran-10,11-dione Chemical compound O=C1C(=O)C2=C3CCCC(=C)C3=CC=C2C2=C1C(C)=CO2.O=C1C(=O)C2=C3CCC=C(C)C3=CC=C2C2=C1C(C)=CO2 WTPPRJKFRFIQKT-UHFFFAOYSA-N 0.000 claims description 10
- 244000132619 red sage Species 0.000 claims description 10
- 238000005406 washing Methods 0.000 claims description 10
- 238000003809 water extraction Methods 0.000 claims description 10
- 239000000706 filtrate Substances 0.000 claims description 8
- 238000000605 extraction Methods 0.000 claims description 7
- 239000002994 raw material Substances 0.000 claims description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 5
- 239000000741 silica gel Substances 0.000 claims description 5
- 229910002027 silica gel Inorganic materials 0.000 claims description 5
- 239000006228 supernatant Substances 0.000 claims description 5
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims description 4
- 239000008280 blood Substances 0.000 claims description 4
- 210000004369 blood Anatomy 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 239000003480 eluent Substances 0.000 claims description 4
- 206010022437 insomnia Diseases 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 2
- 239000003463 adsorbent Substances 0.000 claims description 2
- 230000007812 deficiency Effects 0.000 claims description 2
- 230000002496 gastric effect Effects 0.000 claims description 2
- 238000007911 parenteral administration Methods 0.000 claims description 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 2
- 239000004615 ingredient Substances 0.000 abstract description 2
- 239000006286 aqueous extract Substances 0.000 abstract 4
- 238000010992 reflux Methods 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 1
- 230000003285 pharmacodynamic effect Effects 0.000 abstract 1
- 150000007965 phenolic acids Chemical class 0.000 abstract 1
- 238000011160 research Methods 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 230000000144 pharmacologic effect Effects 0.000 description 7
- 241000721047 Danaus plexippus Species 0.000 description 4
- 230000000147 hypnotic effect Effects 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- QGMRQYFBGABWDR-UHFFFAOYSA-M Pentobarbital sodium Chemical compound [Na+].CCCC(C)C1(CC)C(=O)NC(=O)[N-]C1=O QGMRQYFBGABWDR-UHFFFAOYSA-M 0.000 description 3
- 230000002567 autonomic effect Effects 0.000 description 3
- 230000001914 calming effect Effects 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 230000004622 sleep time Effects 0.000 description 3
- 235000019640 taste Nutrition 0.000 description 3
- FTOAOBMCPZCFFF-UHFFFAOYSA-N 5,5-diethylbarbituric acid Chemical compound CCC1(CC)C(=O)NC(=O)NC1=O FTOAOBMCPZCFFF-UHFFFAOYSA-N 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 229960002275 pentobarbital sodium Drugs 0.000 description 2
- 230000004620 sleep latency Effects 0.000 description 2
- 230000002557 soporific effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- KWTSXDURSIMDCE-QMMMGPOBSA-N (S)-amphetamine Chemical compound C[C@H](N)CC1=CC=CC=C1 KWTSXDURSIMDCE-QMMMGPOBSA-N 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- BKGUPIVDQHHVMV-RZGKOBFOSA-N Gomisin B Chemical compound COC1=C2C=3C(OC)=C(OC)C(OC)=CC=3[C@H](OC(=O)C(\C)=C/C)[C@@](C)(O)[C@@H](C)CC2=CC2=C1OCO2 BKGUPIVDQHHVMV-RZGKOBFOSA-N 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- NPPQSCRMBWNHMW-UHFFFAOYSA-N Meprobamate Chemical compound NC(=O)OCC(C)(CCC)COC(N)=O NPPQSCRMBWNHMW-UHFFFAOYSA-N 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241001072909 Salvia Species 0.000 description 1
- 235000017276 Salvia Nutrition 0.000 description 1
- YMGFTDKNIWPMGF-QHCPKHFHSA-N Salvianolic acid A Natural products OC(=O)[C@H](Cc1ccc(O)c(O)c1)OC(=O)C=Cc2ccc(O)c(O)c2C=Cc3ccc(O)c(O)c3 YMGFTDKNIWPMGF-QHCPKHFHSA-N 0.000 description 1
- YMGFTDKNIWPMGF-UCPJVGPRSA-N Salvianolic acid A Chemical compound C([C@H](C(=O)O)OC(=O)\C=C\C=1C(=C(O)C(O)=CC=1)\C=C\C=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 YMGFTDKNIWPMGF-UCPJVGPRSA-N 0.000 description 1
- 240000006079 Schisandra chinensis Species 0.000 description 1
- 235000008422 Schisandra chinensis Nutrition 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- HTBWBWWADZJXID-TXEJJXNPSA-N Wuweizisu C Chemical compound COC1=C2C=3C(OC)=C4OCOC4=CC=3C[C@H](C)[C@H](C)CC2=CC2=C1OCO2 HTBWBWWADZJXID-TXEJJXNPSA-N 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 229940025084 amphetamine Drugs 0.000 description 1
- 238000000540 analysis of variance Methods 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 229960002319 barbital Drugs 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- RNFNDJAIBTYOQL-UHFFFAOYSA-N chloral hydrate Chemical compound OC(O)C(Cl)(Cl)Cl RNFNDJAIBTYOQL-UHFFFAOYSA-N 0.000 description 1
- 229960002327 chloral hydrate Drugs 0.000 description 1
- ZPEIMTDSQAKGNT-UHFFFAOYSA-N chlorpromazine Chemical compound C1=C(Cl)C=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 ZPEIMTDSQAKGNT-UHFFFAOYSA-N 0.000 description 1
- 229960001076 chlorpromazine Drugs 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 239000000890 drug combination Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002212 flavone derivatives Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- HTBWBWWADZJXID-UHFFFAOYSA-N gamma-schisandrin Natural products COC1=C2C=3C(OC)=C4OCOC4=CC=3CC(C)C(C)CC2=CC2=C1OCO2 HTBWBWWADZJXID-UHFFFAOYSA-N 0.000 description 1
- 230000007954 hypoxia Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 229930183842 salvianolic acid Natural products 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 235000017709 saponins Nutrition 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- YEFOAORQXAOVJQ-RZFZLAGVSA-N schisandrol a Chemical compound C1[C@H](C)[C@@](C)(O)CC2=CC(OC)=C(OC)C(OC)=C2C2=C1C=C(OC)C(OC)=C2OC YEFOAORQXAOVJQ-RZFZLAGVSA-N 0.000 description 1
- ZIBVHHLTJKYXEB-JVEYMCPDSA-N schisantherin B Natural products COc1cc2C[C@H](C)[C@](C)(O)[C@H](OC(=O)C(=CC)C)c3cc4OCOc4c(OC)c3c2c(OC)c1OC ZIBVHHLTJKYXEB-JVEYMCPDSA-N 0.000 description 1
- BKGUPIVDQHHVMV-UHFFFAOYSA-N schisantherin C Natural products COC1=C2C=3C(OC)=C(OC)C(OC)=CC=3C(OC(=O)C(C)=CC)C(C)(O)C(C)CC2=CC2=C1OCO2 BKGUPIVDQHHVMV-UHFFFAOYSA-N 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000008667 sleep stage Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- YEFOAORQXAOVJQ-UHFFFAOYSA-N wuweizischun A Natural products C1C(C)C(C)(O)CC2=CC(OC)=C(OC)C(OC)=C2C2=C1C=C(OC)C(OC)=C2OC YEFOAORQXAOVJQ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a medicine composition, and particularly relates to a medicine composition containing active ingredients of jujube kernel tranquilizing pellets. The composition is prepared from spina date seed aqueous extract, salviae miltiorrhizae aqueous extract and lignan extract of fructus schizandrae, wherein the weight ratio of spina date seed to salviae miltiorrhizae to fructus schizandrae is (5-20):(1-5):(1-5); the spina date seed aqueous extract is prepared by purifying water reflux extract of spina date seeds by means of macroporous adsorption resin; the salviae miltiorrhizae aqueous extract is a total phenolic acid extract prepared by purifying water reflux extract of salviae miltiorrhizae by means of macroporous adsorption resin; and the lignan extract of fructus schizandrae is prepared by carrying out CO2 supercritical extraction on fructus schizandrae. The composition is determined by early pharmacodynamic material basis researches and is a natural ingredient composition capable of improving sleeping very well.
Description
Technical field
The invention belongs to medical art, relate to a kind of pharmaceutical composition, particularly a kind of pharmaceutical composition containing sedative jujube kernel granule active component.
Background technology
Sedative jujube kernel granule, be a kind of Chinese medicine, formula is: Semen Ziziphi Spinosae 250 grams, Radix Salviae Miltiorrhizae 50 grams, Fructus Schisandrae Chinensis 50 grams.
Semen Ziziphi Spinosae sour in the mouth in side, property is put down, and enter the heart, Liver Channel, merit is apt to tranquilizing by nourishing the heart.For monarch drug.Radix Salviae Miltiorrhizae also enters the heart, Liver Channel, nourishes blood and blood in side, the void of reinforcing the heart liver to effect a permanent cure, gains in depth of comprehension its help, then can " nourish heart sedate, and calming heart and tranquilizing mind takes charge of ministerial drug.Fructus Schisandrae Chinensis sour in the mouth, warm in nature, GUIXIN warp, both can Qi-benefiting and heart-nourishing and calming the nerves, and the god's that can get into the frame of mind for work again is more floating, makes god return Qi She, therefore is adjuvant drug.All three tastes of full presciption medicine, brief precise and appropriate, combined into, play the effect of tranquilizing by nourishing the heart altogether.
Clinical and pharmacological evaluation all proves that Semen Ziziphi Spinosae has the pharmacological action of significant calmness, hypnosis.Be experimental studies have found that by the tranquilizing soporific of mice, Semen Ziziphi Spinosae total flavonoids, total saponins and total alkaloids all obviously can suppress the autonomic activities number of times of mice, shorten the Sleep latency that pentobarbital sodium causes, and extend the length of one's sleep.By the change of electroencephalogram, electromyogram, electro-oculogram as the differentiation index of sleep stage, observe the S sleep time that Semen Ziziphi Spinosae extract can extend laboratory animal, shorten Sleep latency, obviously extend the sound sleep time.
Salvia Miltriorrhiza Bge On The Central Nervous System has inhibitory action, can increase the hypoxia-bearing capability of cerebral tissue, improve ability of learning and memory in mice, resists the psychomotor excitation of amfetamine significantly.Radix Salviae Miltiorrhizae is used alone and can significantly suppresses mice autonomic activities, during Western medicine barbital, chloral hydrate, chlorpromazine, miltown drug combination with calming soporific, inhibition and the hypnotic effect of independent activity of animals significantly strengthen, and present the dose-effect relationship of direct ratio.
Fructus Schisandrae Chinensis has obvious calmness, hypnosis, convulsion, improves the pharmacological action of nervous function.Adopt the experiment of mice autonomic activities and the experiment of pentobarbital sodium threshold dose synergism, screening Fructus Schisandrae Chinensis has effective site and the effective ingredient of the effect of hypnosis, and result schisandra chinensis ethyl hydrate extract, schisandrin all have the pharmacological action of anti-insomnia.In addition, schisantherin B, B prime and ester second to have the length of one's sleep above threshold dose of sodium pentobarbitone induced mice first extend, the Bipolar feature of rear suppression, and schisandrin C only has prolongation effect.Fructus Schisandrae Chinensis also possesses the effect regulating animal nervous system function.
In early-stage Study, the discussion of rules for compatibility is carried out to sedative jujube kernel granule.According to monarch, minister, help, make compatibility relationship, with monarch drug Semen Ziziphi Spinosae for core, successively after other two tastes Chinese medicine of compatibility, obtain the 4 kinds of side's of tearing open combinations altogether, respectively anti-insomnia pharmacological evaluation is carried out to these 4 kinds of prescriptions, obtain pharmacological datum.In the result side of showing, monarch drug Semen Ziziphi Spinosae is used alone, without obvious calm, sedative action, with can significant prolongation mouse sleep time after Fructus Schisandrae Chinensis compatibility, with obviously can shorten mice sleep incubation period after Radix Salviae Miltiorrhizae compatibility, difference between known each effective group of Analysis of variance has significant, illustrates that this significant difference is caused by Semen Ziziphi Spinosae and Radix Salviae Miltiorrhizae, Fructus Schisandrae Chinensis compatibility use.
The change of chemical composition in Chinese medicine fingerprint and Pharmacological Results are connected, sets up Chinese medicine spectrum effect relationship, determine that the effective substance of sedative jujube kernel granule is the lignans of salvianolic acid constituents and Fructus Schisandrae Chinensis in flavone component, Radix Salviae Miltiorrhizae in Semen Ziziphi Spinosae.
The present invention, through experimental demonstration, selects to extract three taste the effective elements of the medicines respectively: these three kinds of active components are mixed according to certain ratio, finally obtain pharmaceutical composition of the present invention by Semen Ziziphi Spinosae water extract, Danshen, Fructus Schisandrae Chinensis lignanoid.The present invention also comprises preparation method and the preparation thereof of this pharmaceutical composition.
Summary of the invention
The object of this invention is to provide a kind of pharmaceutical composition containing sedative jujube kernel granule active component.
Another object of the present invention, is to provide a kind of preparation method of the pharmaceutical composition containing sedative jujube kernel granule active component.
A kind of pharmaceutical composition containing sedative jujube kernel granule active component, this pharmaceutical composition is made up of the lignans extract of the water extract of Semen Ziziphi Spinosae, the water extract of Radix Salviae Miltiorrhizae and Fructus Schisandrae Chinensis, to extract parts by weight of raw materials, the ratio Semen Ziziphi Spinosae of each extract: Radix Salviae Miltiorrhizae: Fructus Schisandrae Chinensis is 20:(1-5): (1-5).
Pharmaceutical composition containing sedative jujube kernel granule active component provided by the invention, to extract parts by weight of raw materials, the ratio Semen Ziziphi Spinosae of each extract: Radix Salviae Miltiorrhizae: Fructus Schisandrae Chinensis is 5:1:1.
Pharmaceutical composition containing sedative jujube kernel granule active component provided by the invention, to extract parts by weight of raw materials, the ratio Semen Ziziphi Spinosae of each extract: Radix Salviae Miltiorrhizae: Fructus Schisandrae Chinensis is 10:(2-4): (2-4).
Pharmaceutical composition provided by the invention, also can contain medicine acceptable carrier in said composition as required.
Pharmaceutical composition provided by the invention, said composition is the pharmaceutical preparation of gastrointestinal administration or parenteral administration.
Present invention also offers the preparation method of described pharmaceutical composition, by mixed acid Semen Ziziphi Spinosae water extract, Danshen, Fructus Schisandrae Chinensis lignans extract, prepares with galenic pharmacy routine techniques.
Present invention also offers the preparation method of described pharmaceutical composition, described Semen Ziziphi Spinosae water extract, Danshen, Fructus Schisandrae Chinensis lignans extract is prepared respectively in accordance with the following methods:
(1) Semen Ziziphi Spinosae, water extraction 1-5 time, merge extractive liquid, be concentrated into the clear paste of relative density 1.01-1.08, add equimultiple water gaging, leave standstill, get supernatant, on styrene tyle macroporous adsorption resin, washing (5-8BV), discard water elution liquid, continuous with 50-80% ethanol 4-6BV eluting, collect eluent, drying under reduced pressure is extremely done, be ground into fine powder, obtain Semen Ziziphi Spinosae water extract;
(2) Radix Salviae Miltiorrhizae, water extraction 1-5 time, merge extractive liquid, is concentrated into the clear paste of relative density 1.01-1.08, filter, filtrate, through macroporous adsorbent resin (HPD450, D101, AB8 or HPD600) washing (2-5 BV), discards water elution liquid, continues with 40-60% ethanol 6-10 times amount eluting, collect eluent, drying under reduced pressure, to dry, be ground into fine powder, obtain Danshen;
(3) Fructus Schisandrae Chinensis, is ground into coarse powder, supercritical extraction, extracting pressure 10-20Mpa, extraction temperature 20-30 DEG C, under flow velocity 10-20L/kg.h, extraction 1-2 hour, resolve under pressure 5-8Mpa, it is appropriate that extract adds micropowder silica gel, dry, obtains Fructus Schisandrae Chinensis lignanoid, be ground into fine powder, obtain Fructus Schisandrae Chinensis lignans extract.
The application of pharmaceutical composition provided by the invention on the insomnia drug that causes of preparation treatment heart-liver blood deficiency.
Detailed description of the invention
The following examples will be further described the present invention, but not thereby limiting the invention.
Embodiment 1
The preparation of Semen Ziziphi Spinosae water extract, Danshen, Fructus Schisandrae Chinensis lignanoid:
(1) Semen Ziziphi Spinosae, water extraction 3 times, filters, merging filtrate, is concentrated into the fluid extract of relative density 1.01, adds equimultiple water gaging, leave standstill, get supernatant, through styrene tyle macroporous adsorption resin, with resin and crude drug amount 3:1 upper prop, washing, discards water elution liquid, continue and use 80% ethanol elution, collect 80% ethanol elution, be concentrated into dry, be ground into powder.
(2) Radix Salviae Miltiorrhizae, water extraction 3 times, filters, merging filtrate, be concentrated into the clear paste of relative density 1.01, on the styrene tyle macroporous adsorption resin of HPD600, washing, discard water elution liquid, continue and use 60% ethanol elution, collect 60% ethanol elution, be concentrated into dry, be ground into powder.
(3) Fructus Schisandrae Chinensis, is ground into coarse powder, and through supercritical extraction, extracting pressure 20Mpa, extraction temperature 30 DEG C, after extracting 2 hours, resolves under flow velocity 20L/kg.h under pressure 8Mpa, and it is appropriate that extract adds micropowder silica gel, dry, pulverize into powder.
Embodiment 2
Other preparation methoies of Semen Ziziphi Spinosae water extract, Danshen, Fructus Schisandrae Chinensis lignanoid:
(1) Semen Ziziphi Spinosae, water extraction 2 times, filters, merging filtrate, is concentrated into the fluid extract of relative density 1.05, adds equimultiple water gaging, leave standstill, get supernatant, through styrene tyle macroporous adsorption resin, with resin and crude drug amount 3:1 upper prop, washing, discards water elution liquid, continue and use 60% ethanol elution, collect 60% ethanol elution, be concentrated into dry, be ground into powder.
(2) Radix Salviae Miltiorrhizae, water extraction 2 times, filters, merging filtrate, be concentrated into the clear paste of relative density 1.05, on the styrene tyle macroporous adsorption resin of HPD600, washing, discard water elution liquid, continue and use 50% ethanol elution, collect 50% ethanol elution, be concentrated into dry, be ground into powder.
(3) Fructus Schisandrae Chinensis, is ground into coarse powder, through supercritical extraction, and extracting pressure 10Mpa, extraction temperature 20 DEG C, after extracting 1 hour, resolves under flow velocity 20L/kg.h under pressure 5Mpa, and it is appropriate that extract adds micropowder silica gel, dry, pulverize into powder;
Embodiment 3
Other preparation methoies of Semen Ziziphi Spinosae water extract, Danshen, Fructus Schisandrae Chinensis lignanoid:
(1) Semen Ziziphi Spinosae, water extraction 4 times, filters, merging filtrate, is concentrated into the fluid extract of relative density 1.08, adds equimultiple water gaging, leave standstill, get supernatant, through styrene tyle macroporous adsorption resin, with resin and crude drug amount 3:1 upper prop, washing, discards water elution liquid, continue and use 50% ethanol elution, collect 50% ethanol elution, be concentrated into dry, be ground into powder.
(2) Radix Salviae Miltiorrhizae, water extraction 4 times, filters, merging filtrate, be concentrated into the clear paste of relative density 1.08, on the styrene tyle macroporous adsorption resin of HPD600, washing, discard water elution liquid, continue and use 40% ethanol elution, collect 40% ethanol elution, be concentrated into dry, be ground into powder.
(3) Fructus Schisandrae Chinensis, is ground into coarse powder, and through supercritical extraction, extracting pressure 20Mpa, extraction temperature 20 DEG C, after extracting 2 hours, resolves under flow velocity 20L/kg.h under pressure 5Mpa, and it is appropriate that extract adds micropowder silica gel, dry, pulverize into powder.
Claims (8)
1. the pharmaceutical composition containing sedative jujube kernel granule active component, it is characterized in that: this pharmaceutical composition is made up of the lignans extract of the water extract of Semen Ziziphi Spinosae, the water extract of Radix Salviae Miltiorrhizae and Fructus Schisandrae Chinensis, to extract parts by weight of raw materials, the ratio Semen Ziziphi Spinosae of each extract: Radix Salviae Miltiorrhizae: Fructus Schisandrae Chinensis is 20:(1-5): (1-5).
2., according to the pharmaceutical composition containing sedative jujube kernel granule active component described in claim 1, it is characterized in that: to extract parts by weight of raw materials, the ratio Semen Ziziphi Spinosae of each extract: Radix Salviae Miltiorrhizae: Fructus Schisandrae Chinensis is 10:(2-4): (2-4).
3., according to the pharmaceutical composition containing sedative jujube kernel granule active component described in claim 2, it is characterized in that: to extract parts by weight of raw materials, the ratio Semen Ziziphi Spinosae of each extract: Radix Salviae Miltiorrhizae: Fructus Schisandrae Chinensis is 5:1:1.
4. a pharmaceutical composition as claimed in claim 1, as required also containing medicine acceptable carrier in said composition.
5. a pharmaceutical composition as claimed in claim 1, said composition is the pharmaceutical preparation of gastrointestinal administration or parenteral administration.
6. a preparation method for pharmaceutical composition as claimed in claim 1, is characterized in that: by mixed acid Semen Ziziphi Spinosae water extract, Danshen, and Fructus Schisandrae Chinensis lignans extract is prepared with galenic pharmacy routine techniques.
7. a preparation method for pharmaceutical composition described in claim 6, is characterized in that: described Semen Ziziphi Spinosae water extract, Danshen, and Fructus Schisandrae Chinensis lignans extract is prepared respectively in accordance with the following methods:
(1) Semen Ziziphi Spinosae, water extraction 1-5 time, merge extractive liquid, be concentrated into the clear paste of relative density 1.01-1.08, add equimultiple water gaging, leave standstill, get supernatant, on styrene tyle macroporous adsorption resin, washing (5-8BV), discard water elution liquid, continuous with 50-80% ethanol 4-6BV eluting, collect eluent, drying under reduced pressure is extremely done, be ground into fine powder, obtain Semen Ziziphi Spinosae water extract;
(2) Radix Salviae Miltiorrhizae, water extraction 1-5 time, merge extractive liquid, is concentrated into the clear paste of relative density 1.01-1.08, filter, filtrate, through macroporous adsorbent resin (HPD450, D101, AB8 or HPD600) washing (2-5 BV), discards water elution liquid, continues with 40-60% ethanol 6-10 times amount eluting, collect eluent, drying under reduced pressure, to dry, be ground into fine powder, obtain Danshen;
(3) Fructus Schisandrae Chinensis, is ground into coarse powder, supercritical extraction, extracting pressure 10-20Mpa, extraction temperature 20-30 DEG C, under flow velocity 10-20L/kg.h, extraction 1-2 hour, resolve under pressure 5-8Mpa, it is appropriate that extract adds micropowder silica gel, dry, obtains Fructus Schisandrae Chinensis lignanoid, be ground into fine powder, obtain Fructus Schisandrae Chinensis lignans extract.
8. the application of pharmaceutical composition according to claim 1 on the insomnia drug that causes of preparation treatment heart-liver blood deficiency.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109091615A (en) * | 2018-10-19 | 2018-12-28 | 浙江中医药大学 | A kind of Chinese medicine composition and application for treatment of insomnia patients |
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| CN1368062A (en) * | 2001-02-05 | 2002-09-11 | 杨孟君 | Nano medicine 'Zaorenanshen' and its preparing process |
| CN1435206A (en) * | 2002-01-30 | 2003-08-13 | 贵州仙灵药业股份有限公司 | Sedative jujube kernel capsule |
| CN1682918A (en) * | 2005-03-08 | 2005-10-19 | 北京正大绿洲医药科技有限公司 | Tranquilizing wild jujube seed dripping pill and its preparing method |
| CN103272018A (en) * | 2013-05-10 | 2013-09-04 | 华南理工大学 | Sedative and hypnotic active saponin components of spina date seed, as well as separation and purification method and application of sedative and hypnotic active saponin components |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1368062A (en) * | 2001-02-05 | 2002-09-11 | 杨孟君 | Nano medicine 'Zaorenanshen' and its preparing process |
| CN1435206A (en) * | 2002-01-30 | 2003-08-13 | 贵州仙灵药业股份有限公司 | Sedative jujube kernel capsule |
| CN1682918A (en) * | 2005-03-08 | 2005-10-19 | 北京正大绿洲医药科技有限公司 | Tranquilizing wild jujube seed dripping pill and its preparing method |
| CN103272018A (en) * | 2013-05-10 | 2013-09-04 | 华南理工大学 | Sedative and hypnotic active saponin components of spina date seed, as well as separation and purification method and application of sedative and hypnotic active saponin components |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109091615A (en) * | 2018-10-19 | 2018-12-28 | 浙江中医药大学 | A kind of Chinese medicine composition and application for treatment of insomnia patients |
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