CN104435277A - Traditional Chinese medicine aerosol for treating cute attack of pulmonary heart disease and preparation method thereof - Google Patents
Traditional Chinese medicine aerosol for treating cute attack of pulmonary heart disease and preparation method thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/30—Extraction of the material
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention discloses a traditional Chinese medicine aerosol for treating cute attack of pulmonary heart disease. The aerosol is prepared from the following raw medicinal materials in parts by weight: 30-60 parts of jasmine tea, 1-7 parts of ossa draconis, 5-9 parts of Chinese herring meat, 1-6 parts of trichosanthes peel, 6-9 parts of pepper, 2-7 parts of raw liquorice, 3-8 parts of radix bupleuri, 1-5 parts of cortex albiziae, 5-15 parts of astragalus membranaceus, 8-18 parts of blackone chicken, 1-5 parts of lucid ganoderma and 5-10 parts of typhonium giganteum. The aerosol disclosed by the invention has the characteristics of being easy to operate, remarkable in curative effect and free of side effects, can further improve the inner immune function of the human body and enhance the anti-disease ability of the body and has the functions of treating pulmonary heart disease, tonifying spleen and kidney, promoting qi to activate blood, relieving cough and reducing sputum and relieving chest stuffiness and pain.
Description
Technical field
The invention belongs to traditional Chinese medicine field, it relates to a kind of Traditional Chinese medicinal aerosol for the treatment of acute episode of cor pulmonale by combination and preparation method thereof.
Background technology
Pulmonary heart disease (abbreviation pulmonary heart disease) heart disease that mainly pulmonary hypertension causes caused by Bronchi-pulmonary tissue or pulmonary artery pathological changes.According to onset emergency and course of disease length, acute and chronic two classes can be divided into.Common with the latter clinically., clinically except the various sings and symptomses of original lung, breast disease, mainly progressively there is the sign of lung, heart failure and other organ injuries in primary disease slower development.
1. secondly bronchus, lung disease: the most common with the concurrent obstructive emphysema of chronic bronchitis be bronchial asthma, bronchiectasis, serious pulmonary tuberculosis, pneumoconiosis, chronic diffuse interstitial pulmonary fibrosis, sarcoidosis, sequoiosis, eosinophilic granuloma etc.2. movement of thorax obstacle disease: more rare, after serious vertebra, convex, the extensive adhesion of spondylocace, rheumatoid arthritis, pleura in side and thorax form the postoperative serious thorax that causes or spine malformation, and neuromuscular illness is as poliomyelitis.3. pulmonary vascular disease: rare.Involve Pulmonic allergic granulomatosis, the multiple pulmonary arteriolar embolism extensively or repeatedly occurred and lung arteriolitis, and agnogenic primary pulmonary hypertension, develop into pulmonary heart disease.
Chronic pulmonary heart disease is that pulmonary vascular resistance caused by chronic bronchial, lung, thorax or pulmonary artery chronic disease increases, pulmonary hypertension and then make Right ventricular hypertrophy, expansion, companion or do not accompany the heart disease of right heart function exhaustion.Acute pulmonary heart disease is mainly by main pulmonary artery or the unexpected thromboembolism of its Main Branches, is obstructed in the large portion of pulmonary circulation, so that pulmonary artery pressure sharply increases, acute right ventricles is expanded and the heart disease of right ventricular function exhaustion.Division is carried out by compensatory phase of its function and Decompensated stage.
1. lung, cardiac functional compensatory period (comprising the catabasis): the performance of this phase mainly chronic obstructive pulmonary disease (abbreviation chronic obstructive pulmonary disease).Chronic cough, expectoration, out of breath, cardiopalmus after movable, dyspnea, weak and work tolerance decline.Health check-up can have obvious emphysema to levy, auscultation diminished breath sound, occasionally has dry, moist rales, the slight edema of lower limb, and afternoon is obvious, and secondary morning disappears.Border of cardiac dullness is often not easily kowtowed out because of emphysema.Hear sounds is remote, but pulmonary area can have second heart sound hyperfunction, and prompting has pulmonary hypertension.TA shows heartbeat under there is systolic murmur or xiphoid-process, and many promptings have Right ventricular hypertrophy, expansion.Some cases makes intrapleural pressure raise because of emphysema, hinders Vena cava return, and visible jugular vein fills.Again because diaphragm declines, the liver upper bound and lower edge are moved down significantly.2. lung, cardiac functional decompensatory period (comprising Acute Exacerbation Period): the current period, clinical main manifestations was based on respiratory failure, to have or without heart failure.
Compare with western medicine and medical practitioners, by Chinese traditional treatment, toxic and side effects is comparatively light, is more vulnerable to the favor of numerous medical personnels and friend patient.The Chinese patent literature of Authorization Notice No. CN 1294926C (application number 200410015856.2) provides a kind ofly treats the formula of the Chinese medicine composition of pulmonary heart disease and prepares native skill, comprise stock and adjunct, composition of raw materials proportioning be Radix Astragali 1-5 part, Semen Lepidii (Semen Descurainiae) 1-5 part, Rhizoma Chuanxiong 1-5 part, draw together building skin 1-5 part and adjuvant composition.The Chinese patent literature of Authorization Notice No. CN100496530C (application number 200410018562.5) relates to a kind of Chinese medicine composition for the treatment of pulmonary heart disease, comprise medium-height grass medicinal herbs Semen Lepidii (Semen Descurainiae), Rhizoma Chuanxiong, formula is made up of Semen Lepidii (Semen Descurainiae) or its extract 1-3 part, Rhizoma Chuanxiong or its extract 1-2 part and suitable most adjuvant by portion rate preparation.Publication number CN 101229267A (application number 200810056134.X) relates to and a kind ofly treats pharmaceutical composition of pulmonary heart disease and rheumatic heart disease and preparation method thereof, and it is made primarily of Semen Persicae, Flos Carthami, Radix Angelicae Sinensis, the Radix Rehmanniae, CHUANSHAO, Radix Paeoniae Rubra, Radix Achyranthis Bidentatae, Radix Platycodonis, Radix Bupleuri, long-pending reality and Radix Glycyrrhizae.
Also there are some problems in foregoing invention: great majority are all pure Chinese medicinal preparations in treatment pulmonary heart disease, life-time service can bring very serious stimulation to health, as everyone knows, pulmonary heart disease is chronic disease, just can not cure for the moment, focus on conditioning and treatment, but during acute episode of cor pulmonale by combination, but very serious.
Summary of the invention
For the present situation of existing treatment pulmonary heart disease deficiency, and provide a kind of Traditional Chinese medicinal aerosol for the treatment of acute episode of cor pulmonale by combination, there is easy to operate, the evident in efficacy and feature had no side effect, inside of human body immunologic function can also be improved, the resistance against diseases of enhancing body, there is treatment pulmonary heart disease, strengthening spleen, tonifying kidney, effect of promoting flow of QI and blood, relieving cough and resolving phlegm, the chest stuffiness relieving pain relieving.
Another object of the present invention is just to provide the preparation method of above-mentioned Traditional Chinese medicinal aerosol.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
The Traditional Chinese medicinal aerosol for the treatment of acute episode of cor pulmonale by combination, each crude drug is as follows, is weight portion: Jasmine tea 30-60, Os Draconis 1-7, Ilisha elongata 5-9, Pericarpium Trichosanthis 1-6, Pericarpium Zanthoxyli 6-9, Radix Glycyrrhizae 2-7, Radix Bupleuri 3-8, Cortex Albiziae 1-5, Radix Astragali 5-15, Gallus Domesticus 8-18, Ganoderma 1-5, Herba Typhonii gigantei 5-10.
The Traditional Chinese medicinal aerosol for the treatment of acute episode of cor pulmonale by combination, preferred scheme is, each crude drug is as follows, be weight portion: Jasmine tea 40-50, Os Draconis 3-5, Ilisha elongata 6-8, Pericarpium Trichosanthis 2-5, Pericarpium Zanthoxyli 7-8, Radix Glycyrrhizae 3-6, Radix Bupleuri 4-7, Cortex Albiziae 2-4, Radix Astragali 8-13, Gallus Domesticus 10-16, Ganoderma 2-4, Herba Typhonii gigantei 6-9.
The Traditional Chinese medicinal aerosol for the treatment of acute episode of cor pulmonale by combination, better preferred scheme is that each crude drug is as follows, is weight portion: Jasmine tea 45, Os Draconis 4, Ilisha elongata 7, Pericarpium Trichosanthis 3, Pericarpium Zanthoxyli 7.5, Radix Glycyrrhizae 5, Radix Bupleuri 6, Cortex Albiziae 3, the Radix Astragali 10, Gallus Domesticus 14, Ganoderma 3, Herba Typhonii gigantei 7.
The preparation method of above-mentioned Traditional Chinese medicinal aerosol, preparation process is as follows:
(1) decaptitated by Gallus Domesticus and bone, the block that blackbone Chicken is cut into soybean grain size is put on iron plate together with the Ilisha elongata of cutting into inch strips, and iron plate is put a little Oleum Arachidis hypogaeae semen, large burn heat after change little fire and decoct 15-30 minute slowly, after cooling, it is stand-by firmly to grind to form smalls;
(2) smashed by Os Draconis, be placed in suitable container, on smokeless stove fire, forging is crisp, grinds to form smalls, crosses 80-120 mesh sieve;
(3) Jasmine tea is placed in clean container, add raw material gross weight 9-13 hot water doubly, be dipped to the whole variable color of hot water, taken out by Jasmine tea, filtrate is for subsequent use, the Jasmine tea after immersion and Pericarpium Trichosanthis, Radix Glycyrrhizae, the Radix Astragali and Ganoderma white vinegar is soaked 3-7 hour (preferably 5 hours), taking-up is placed in low baking temperature on tile and is dried to savory blowing out slowly, dry in the air and be coolly placed in mortar, grind to form fine powder, cross 80-100 mesh sieve stand-by;
(4) Pericarpium Zanthoxyli, Radix Bupleuri, Cortex Albiziae and Herba Typhonii gigantei are added in step (3) gained filtrate, mixing, intense fire is fried open, and turns 30-60 at a simmer minute and adds step (1)-(2) institute's smalls and step (3) gained fine powder, continue slow fire boiling 10-20 minute, filter to get filtrate 1, the filtering residue low baking temperature that adds water decocts 40-60 minute slowly, filters, obtains filtrate 2, twice filtrate is merged, must filtrate be mixed;
(5) by step (4) gained mixing filtrate, sealing and standing 15-25 hour, gets supernatant, bottles and obtains Traditional Chinese medicinal aerosol.
The preparation method of foregoing Traditional Chinese medicinal aerosol, step (1) changes little fire and decocts slowly 18-28 minute (preferred, to change little fire and decoct 25 minutes slowly after large baked wheaten cake heat) after burning heat greatly.
The preparation method of foregoing Traditional Chinese medicinal aerosol, step (2) smalls crosses 90-110 mesh sieve (preferred, smalls crosses 100 mesh sieves).
The preparation method of foregoing Traditional Chinese medicinal aerosol, step (3) adds raw material gross weight 10-12 hot water doubly (preferred, to add the hot water of raw material gross weight 11 times).
The preparation method of foregoing Traditional Chinese medicinal aerosol, Jasmine tea after immersion and Pericarpium Trichosanthis, Radix Glycyrrhizae, the Radix Astragali and Ganoderma white vinegar soak 4-6 hour (preferred, the Jasmine tea after immersion and Pericarpium Trichosanthis, Radix Glycyrrhizae, the Radix Astragali and Ganoderma white vinegar are soaked 5 hours) by step (3).
The preparation method of foregoing Traditional Chinese medicinal aerosol, step (4) the filtering residue low baking temperature that adds water is decocted 45-55 minute (preferred, the filtering residue low baking temperature that adds water decocts 50 minutes slowly) slowly.
The preparation method of foregoing Traditional Chinese medicinal aerosol, step (5) mixing filtrate sealing and standing 18-23 hour (preferred, mixing filtrate sealing and standing 20 hours).
Using method: for making the present invention reach optimum therapeuticing effect, gets Traditional Chinese medicinal aerosol 1-3ml of the present invention, and sugaring that can be suitable according to the taste of individual, when each pulmonary heart disease is shown effect, does not spray into from oral cavity, within 5 days, is a course for the treatment of.
This Traditional Chinese medicinal aerosol is to the Be very effective of pulmonary heart disease, there is treatment pulmonary heart disease, strengthening spleen, tonifying kidney, effect of promoting flow of QI and blood, relieving cough and resolving phlegm, the chest stuffiness relieving pain relieving, the body constitution for the treatment of patient weakness because of chronic pain, and the local common medical material of multiselect of the present invention, cheap, alleviate the financial burden of patient.
The Traditional Chinese medicinal aerosol for the treatment of acute episode of cor pulmonale by combination, the pharmacological effect of each crude drug is respectively:
Jasmine tea: Jasmine tea belongs to scented tea class, belong to reprocessing tea] one, be also called jasmine scented tea.Making material is Folium Camelliae sinensis and Flos Jasmini Sambac, therefore can have the fragrance of the two concurrently.Jasmine tea, the famous-object in fumigate tea.Jasmine tea has the nutritional labeling of green tea and Flos Jasmini Sambac concurrently, be rich in the various nutrient elements such as chlorophyll, catechin, theanine, caffeine, tea polyphenols, vitamin A, vitamin C, vitamin E, carotene, calcium, phosphorus, potassium, leucine, lysine, phenylalanine, glutamic acid, alanine, aspartic acid, Chinese medicine voluminous dictionary " in record: Flos Jasmini Sambac has " regulating the flow of QI to alleviate depression, ward off dirty and in " effect, and dysentery, stomachache, conjunctivitis and sore etc. are had to the effect of good eliminating inflammation and expelling toxin.Normal drink Flos Jasmini Sambac, has liver heat removing and eyesight improving, promoting the production of body fluid to quench thirst, eliminates the phlegm and control effect of dysentery, relieving constipation diuretic, expelling pathogenic wind from the body surface, treatment fistula, hard tooth, physical strength profiting, blood pressure lowering, heart tonifying, preventing decayed tooth antiradiation injury, anticancer, defying age, make people's life lengthening, physical and mental health.
Os Draconis: base is former: for mammal in ancient times resembles the Skeletal Fossils of class, rhinoceros class, Hippocampal cortex, bovine, deer class etc.Composition: Os Draconis, mainly containing calcium carbonate and calcium phosphate, still contain ferrum, potassium, sodium, chlorine, sulfate radical etc.The property of medicine: puckery, sweet, flat.GUIXIN, liver, kidney, large intestine channel.Function cures mainly: tranquilizing mind, suppressing the hyperactive liver and subsiding YANG, restrains astringent or styptic treatment for spontaneous sweating.Cure mainly cardiopalmus, seized with terror swollen, insomnia, forgetful, infantile convulsion, demented, dizzy, spontaneous sweating, the seminal emission enuresis, bleeding not during menses, chronic diarrhea and dysentery, ulcer does not close up and eczema for a long time.Compatibility and incompatibility of drugs: the careful clothes of the excess-heat person of stagnating.
Ilisha elongata: base is former: for clupeidae Chinese herring belongs to animal Chinese herring flesh of fish.Composition: meat is containing protein, fatty, calcium, phosphorus, ferrum, riboflavin, nicotinic acid and thiamine.The property of medicine: sweet, flat.Return spleen, stomach warp.Function cures mainly: spleen benefiting and stimulating the appetite, tranquilizing by nourishing the heart.Cure mainly diarrhea due to hypofunction of the spleen, dyspepsia, mouth of keeping silent is not eaten, severe palpitation.
Pericarpium Trichosanthis: the fruit-rind of Chinese trichosanthes is the peel of cucurbitaceous plant Fructus Trichosanthis or trichosanthes rosthornii Harms etc.For the peel of cucurbitaceous plant Fructus Trichosanthis or trichosanthes rosthornii Harms etc.Moistening the lung and resolving phlegm, promoting the circulation of QI the chest stuffiness relieving.Control phlegm-heat cough, pharyngalgia, chest pain, spit blood, epistaxis, quenches one's thirst, constipation, carbuncle pyogenic infections from tumour or sore.
Pericarpium Zanthoxyli: the traditional Chinese medical science is thought, Pericarpium Zanthoxyli is warm in nature, acrid in the mouth, has warming spleen and stomach for dispelling cold, stomach invigorating dehumidifying, pain relieving parasite killing, removing toxic substances are regulated the flow of vital energy, effect of antipruritic raw meat of dispelling; Can be used for treating food stagnation, stop pain of joint muscle, coldness and pain in the epigastrium caused by drink, singultus, vomiting, wind-cold damp pathogen, have loose bowels, dysentery, ascarid, the disease such as pudendal pruritus.Warming spleen and stomach for dispelling cold, dehumidifying, pain relieving, parasite killing, separates fish raw meat poison.Control food stagnation and stop drink, trusted subordinate's cold type of pain, vomiting, oh, cough gas Pericarpium Zanthoxyli is inverse, and anemofrigid-damp arthralgia, has loose bowels, dysentery, colic, toothache, ascariasis, enterobiasis, pudendal pruritus, skin ulcer scabies.
Radix Glycyrrhizae: another name Glycyrrhizae, close sweet, close grass, state are old, Radix Glycyrrhizae, Herba Hedyotis cantonensis, sweet root, excellent grass system pulse family herbaceos perennial.The traditional Chinese medical science thinks that it has the effect of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the mediation property of medicine, nature and flavor: sweet, flat.Gui Jing: GUIXIN, lung, spleen, stomach warp.Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Radix Bupleuri: another name ground is smoked, mountain dish, mushroom are careless, faggot.Nature and flavor are bitter, are slightly cold.Return liver, gallbladder meridian.There is reconciling superficies and interior, soothing the liver, effect of yang invigorating.For cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterine prolapse, menoxenia.
Cortex Albiziae: Cortex Albiziae is the dry bark of pulse family (LeguminOsae) plant Herba Albiziae, in curling tubular or half tubular, long 40 ~ 80cm, thick Cortex Albiziae 0.1 ~ 0.3cm.Outer surface taupe brown is to taupe, and nature and flavor are sweet, flat.There is the merit of resolving depression and blood, mind calming, subduing inflammation.There is the effect controlling irritability, melancholy, insomnia, lung abscess, carbuncle, scrofula, injured bone.
The Radix Astragali: the Radix Astragali, has another name called continuous stilbene.Perennial herb, high 50-100 centimetre.Main root is plump, wooden, normal branch, canescence.Stem is upright, and top multi-branched, has thin rib, by white pubescence.It has enhancing human body immunity function, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.But table excess pathogen is contained, retention of dampness due to stagnation of QI, and food stagnation is stagnated, carbuncle from the beginning of or the excess syndrome such as pyretic toxicity Shang Sheng after bursting, and hyperactivity of YANG due to deficiency of YIN person, must prohibit clothes.
Gallus Domesticus: Gallus Domesticus, also known as Wushan Chickens, Gallus Domesticus (Silky fowl), is that a kind of omnivorous family keeps pet.Sweet, flat.Control asthenia exopathogenic heat, wasting, extremity asthenia, dysphoria with feverish sensation in the chest palms and soles, dry pharynx cheek is red, the timid hectic fever of the heart, and night sweat subtracts food, cough pus and blood.Gallus Domesticus property is flat, sweet in the mouth; There is the effects such as nourishing YIN and clearing away heat, the liver and the kidney tonifying, invigorating the spleen to arrest diarrhea.Edible Gallus Domesticus, can improving physiological function, slow down aging, strengthening the tendons and bones, having obvious effect to preventing and treating osteoporosis, rickets, women's iron deficiency anemia etc.
Ganoderma: Ganoderma profile is umbrella, cap kidney shape, semicircle or subcircular are the sporophore of On Polyporaceae Ganoderma.There is effect of invigorating QI and tranquilization, relieving cough and asthma, for dizzy sleeplessness, shortness of breath and palpitation, asthenia cough with asthma.
Herba Typhonii gigantei: another name Rhizoma Typhonium Gigantei (Rhizoma Typhonii), milk in vain attached, red male star, numb taro, the wild Rhizoma Pinelliae, Cor Gigeriae Galli are attached in vain.Flavor efficacy acrid, sweet, warm.Poisonous.Return stomach, Liver Channel.Function drying dampness to eliminate phlegm, timid wind relieving convulsion, removing toxic substances powder knot.Be applicable to the stagnant network of wind-phlegm, facial hemiparalysis, apoplexy abundant expectoration, aphasia hemiplegia, tetanus and headache due to cold-damp; External is used for sucutaneous nodule scrofula, venom.
Traditional Chinese medicinal aerosol of the present invention is based on the principle of traditional Chinese medical herbal treatment pulmonary heart disease.The existing strengthening spleen, tonifying kidney of the Chinese medicinal material selected, effect of promoting flow of QI and blood, relieving cough and resolving phlegm, the chest stuffiness relieving pain relieving, and cheap, life-time service also can not cause the financial burden of patient, is to treat the ideal medicine of pulmonary heart disease.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
Embodiment 1 treats the Traditional Chinese medicinal aerosol of acute episode of cor pulmonale by combination, and each crude drug is as follows, is weight portion (getting 10g for every part): Jasmine tea 30, Os Draconis 1, Ilisha elongata 5, Pericarpium Trichosanthis 1, Pericarpium Zanthoxyli 6, Radix Glycyrrhizae 2, Radix Bupleuri 3, Cortex Albiziae 1, the Radix Astragali 5, Gallus Domesticus 8, Ganoderma 1, Herba Typhonii gigantei 5.
The preparation method of the Traditional Chinese medicinal aerosol of above-mentioned treatment acute episode of cor pulmonale by combination, step is:
(1) decaptitated by Gallus Domesticus and bone, the block that blackbone Chicken is cut into soybean grain size is put on iron plate together with the Ilisha elongata of cutting into inch strips, and iron plate is put a little Oleum Arachidis hypogaeae semen, large burn heat after change little fire and decoct 15 minutes, after cooling slowly, it is stand-by firmly to grind to form smalls;
(2) smashed by Os Draconis, be placed in suitable container, on smokeless stove fire, forging is crisp, grinds to form smalls, crosses 80 mesh sieves;
(3) Jasmine tea is placed in clean container, add the hot water of raw material gross weight 9 times, be dipped to the whole variable color of hot water, taken out by Jasmine tea, filtrate is for subsequent use, and the Jasmine tea after immersion and Pericarpium Trichosanthis, Radix Glycyrrhizae, the Radix Astragali and Ganoderma white vinegar are soaked 3 hours, taking-up is placed in low baking temperature on tile and is dried to savory blowing out slowly, dry in the air and be coolly placed in mortar, grind to form fine powder, cross 80 mesh sieves stand-by;
(4) Pericarpium Zanthoxyli, Radix Bupleuri, Cortex Albiziae and Herba Typhonii gigantei are added in step (3) gained filtrate, mixing, intense fire is fried open, and turns and within 30 minutes at a simmer, adds step (1)-(2) institute's smalls and step (3) gained fine powder, continues slow fire boiling 10 minutes, filter to get filtrate 1, the filtering residue low baking temperature that adds water decocts 40 minutes slowly, filters, obtains filtrate 2, twice filtrate is merged, must filtrate be mixed;
(5) by step (4) gained mixing filtrate, sealing and standing 15 hours, gets supernatant, bottles and obtains Traditional Chinese medicinal aerosol.
Typical case one Zou so-and-so, female, 49 years old, there is paroxysmal cough without obvious inducement, expectoration in retired cadre from before 10 years, and white mucus expectorant, sometimes sputum mixed with blood silk, be diagnosed as " bronchitis " at that time, penicillin treatment after alleviate.After this weather cools off and winter-spring season recurrent exerbation, takes a turn for the better after taking antibiotic and cough suppressing medicine.Cough in nearest 2 years, expectoration increases the weight of, morning plays aggravation, cough white foam expectorant, as stair climbing after movable, the sense cardiopalmus such as skelp, tachypnea, can alleviate after rest, cardiopalmus is felt after suffering from cold before first quarter moon, tachypnea increases the weight of again, night can not put down sleeping, urine amount reduces, there is low grade fever, body temperature fluctuation is at 37.5 DEG C--and 38.0 DEG C, cough, cough white mucus expectorant, amount 100ml many about every days, without night sweat, chest pain and spitting of blood, the oxygen uptake and taking of being in is brought down a fever, cough-relieving, after Apophlegmatisant, symptom is without alleviation, outpatient service is with " chronic bronchitis, emphysema, pulmonary heart disease respiratory failure " Shou Ren institute.Nearly 3 days, pulmonary heart disease is acute attack always, and when outbreak, sensation has soon been suffocated, and household fears very much, whenever acute attack time, used gained Traditional Chinese medicinal aerosol of the present invention immediately to it.
Take Traditional Chinese medicinal aerosol obtained by the present embodiment 13 days, whenever acute episode of cor pulmonale by combination time, self-induction symptom can be alleviated at once, and continue to take 1 course for the treatment of of embodiment 1 gained Traditional Chinese medicinal aerosol, all diseases disappear substantially, QI and blood is also smooth and easy, chest pain obviously alleviates, and patient uses embodiment 1 gained aerosol always, health very strong, taking period, there is not malaise symptoms always.
Embodiment 2 treats the Traditional Chinese medicinal aerosol of acute episode of cor pulmonale by combination, and each crude drug is as follows, is weight portion (getting 15g for every part): Jasmine tea 60, Os Draconis 7, Ilisha elongata 9, Pericarpium Trichosanthis 6, Pericarpium Zanthoxyli 9, Radix Glycyrrhizae 7, Radix Bupleuri 8, Cortex Albiziae 5, the Radix Astragali 15, Gallus Domesticus 18, Ganoderma 5, Herba Typhonii gigantei 10.
The preparation method of the Traditional Chinese medicinal aerosol of above-mentioned treatment acute episode of cor pulmonale by combination, step is:
(1) decaptitated by Gallus Domesticus and bone, the block that blackbone Chicken is cut into soybean grain size is put on iron plate together with the Ilisha elongata of cutting into inch strips, and iron plate is put a little Oleum Arachidis hypogaeae semen, large burn heat after change little fire and decoct 30 minutes, after cooling slowly, it is stand-by firmly to grind to form smalls;
(2) smashed by Os Draconis, be placed in suitable container, on smokeless stove fire, forging is crisp, grinds to form smalls, crosses 120 mesh sieves;
(3) Jasmine tea is placed in clean container, add the hot water of raw material gross weight 13 times, be dipped to the whole variable color of hot water, taken out by Jasmine tea, filtrate is for subsequent use, and the Jasmine tea after immersion and Pericarpium Trichosanthis, Radix Glycyrrhizae, the Radix Astragali and Ganoderma white vinegar are soaked 7 hours, taking-up is placed in low baking temperature on tile and is dried to savory blowing out slowly, dry in the air and be coolly placed in mortar, grind to form fine powder, cross 100 mesh sieves stand-by;
(4) Pericarpium Zanthoxyli, Radix Bupleuri, Cortex Albiziae and Herba Typhonii gigantei are added in step (3) gained filtrate, mixing, intense fire is fried open, and turns and within 60 minutes at a simmer, adds step (1)-(2) institute's smalls and step (3) gained fine powder, continues slow fire boiling 20 minutes, filter to get filtrate 1, the filtering residue low baking temperature that adds water decocts 60 minutes slowly, filters, obtains filtrate 2, twice filtrate is merged, must filtrate be mixed;
(5) by step (4) gained mixing filtrate, sealing and standing 25 hours, gets supernatant, bottles and obtains Traditional Chinese medicinal aerosol.
Embodiment 3 treats the Traditional Chinese medicinal aerosol of acute episode of cor pulmonale by combination, and each crude drug is as follows, is weight portion (getting 20g for every part): Jasmine tea 40, Os Draconis 3, Ilisha elongata 6, Pericarpium Trichosanthis 2, Pericarpium Zanthoxyli 7, Radix Glycyrrhizae 3, Radix Bupleuri 4, Cortex Albiziae 2, the Radix Astragali 8, Gallus Domesticus 10, Ganoderma 2, Herba Typhonii gigantei 6.
The preparation method of the Traditional Chinese medicinal aerosol of above-mentioned treatment acute episode of cor pulmonale by combination, step is:
(1) decaptitated by Gallus Domesticus and bone, the block that blackbone Chicken is cut into soybean grain size is put on iron plate together with the Ilisha elongata of cutting into inch strips, and iron plate is put a little Oleum Arachidis hypogaeae semen, large burn heat after change little fire and decoct 18 minutes, after cooling slowly, it is stand-by firmly to grind to form smalls;
(2) smashed by Os Draconis, be placed in suitable container, on smokeless stove fire, forging is crisp, grinds to form smalls, crosses 90 mesh sieves;
(3) Jasmine tea is placed in clean container, add the hot water of raw material gross weight 10 times, be dipped to the whole variable color of hot water, taken out by Jasmine tea, filtrate is for subsequent use, and the Jasmine tea after immersion and Pericarpium Trichosanthis, Radix Glycyrrhizae, the Radix Astragali and Ganoderma white vinegar are soaked 4 hours, taking-up is placed in low baking temperature on tile and is dried to savory blowing out slowly, dry in the air and be coolly placed in mortar, grind to form fine powder, cross 75 mesh sieves stand-by;
(4) Pericarpium Zanthoxyli, Radix Bupleuri, Cortex Albiziae and Herba Typhonii gigantei are added in step (3) gained filtrate, mixing, intense fire is fried open, and turns and within 40 minutes at a simmer, adds step (1)-(2) institute's smalls and step (3) gained fine powder, continues slow fire boiling 13 minutes, filter to get filtrate 1, the filtering residue low baking temperature that adds water decocts 45 minutes slowly, filters, obtains filtrate 2, twice filtrate is merged, must filtrate be mixed;
(5) by step (4) gained mixing filtrate, sealing and standing 18 hours, gets supernatant, bottles and obtains Traditional Chinese medicinal aerosol.
Typical case two Wu so-and-so, man, 57 years old, Jinan personage.Patient has asthma medical history 5 years, often coughs at ordinary times, and feels asthma, out of breath and feel suffocated.Unexpected exacerbation of symptoms in 2013, sweating due to debility is dripping, lower limbs edema, and green around the gills emergency treatment is rescued at local hospital, at that time cardiac function level Four, and Color Sonography prompting expands whole-heartedly, heart failure, lung A high pressure.And when each outbreak, patient feels bad extremely, and because the state of an illness is critical, local doctor informs that patient treatment is wished not quite.Go to hospital to do inspection and be diagnosed as acute episode of cor pulmonale by combination, under the suggestion of doctor, bring into use gained Traditional Chinese medicinal aerosol of the present invention.
After taking in the present embodiment 31 course for the treatment of of obtained Traditional Chinese medicinal aerosol, during acute attack, the symptom of precordialgia, cough alleviates, and fatigue and weak also alleviates, the amount of receiving increase, spirit can, take 1 month, the blood supply of electrocardio diagram coronary artery obviously improves, and patient does not show effect so far again.
Embodiment 4 treats the Traditional Chinese medicinal aerosol of acute episode of cor pulmonale by combination, and each crude drug is as follows, is weight portion (getting 25g for every part): Jasmine tea 50, Os Draconis 5, Ilisha elongata 8, Pericarpium Trichosanthis 5, Pericarpium Zanthoxyli 8, Radix Glycyrrhizae 6, Radix Bupleuri 7, Cortex Albiziae 4, the Radix Astragali 13, Gallus Domesticus 16, Ganoderma 4, Herba Typhonii gigantei 9.
The preparation method of the Traditional Chinese medicinal aerosol of above-mentioned treatment acute episode of cor pulmonale by combination, step is:
(1) decaptitated by Gallus Domesticus and bone, the block that blackbone Chicken is cut into soybean grain size is put on iron plate together with the Ilisha elongata of cutting into inch strips, and iron plate is put a little Oleum Arachidis hypogaeae semen, large burn heat after change little fire and decoct 28 minutes, after cooling slowly, it is stand-by firmly to grind to form smalls;
(2) smashed by Os Draconis, be placed in suitable container, on smokeless stove fire, forging is crisp, grinds to form smalls, crosses 90 mesh sieves;
(3) Jasmine tea is placed in clean container, add the hot water of raw material gross weight 12 times, be dipped to the whole variable color of hot water, taken out by Jasmine tea, filtrate is for subsequent use, and the Jasmine tea after immersion and Pericarpium Trichosanthis, Radix Glycyrrhizae, the Radix Astragali and Ganoderma white vinegar are soaked 6 hours, taking-up is placed in low baking temperature on tile and is dried to savory blowing out slowly, dry in the air and be coolly placed in mortar, grind to form fine powder, cross 95 mesh sieves stand-by;
(4) Pericarpium Zanthoxyli, Radix Bupleuri, Cortex Albiziae and Herba Typhonii gigantei are added in step (3) gained filtrate, mixing, intense fire is fried open, and turns and within 50 minutes at a simmer, adds step (1)-(2) institute's smalls and step (3) gained fine powder, continues slow fire boiling 18 minutes, filter to get filtrate 1, the filtering residue low baking temperature that adds water decocts 55 minutes slowly, filters, obtains filtrate 2, twice filtrate is merged, must filtrate be mixed;
(5) by step (4) gained mixing filtrate, sealing and standing 23 hours, gets supernatant, bottles and obtains Traditional Chinese medicinal aerosol.
Embodiment 5 treats the Traditional Chinese medicinal aerosol of acute episode of cor pulmonale by combination, and each crude drug is as follows, is weight portion (getting 30g for every part): Jasmine tea 45, Os Draconis 4, Ilisha elongata 7, Pericarpium Trichosanthis 3, Pericarpium Zanthoxyli 7.5, Radix Glycyrrhizae 5, Radix Bupleuri 6, Cortex Albiziae 3, the Radix Astragali 10, Gallus Domesticus 14, Ganoderma 3, Herba Typhonii gigantei 7.
The preparation method of the Traditional Chinese medicinal aerosol of above-mentioned treatment acute episode of cor pulmonale by combination, step is:
(1) decaptitated by Gallus Domesticus and bone, the block that blackbone Chicken is cut into soybean grain size is put on iron plate together with the Ilisha elongata of cutting into inch strips, and iron plate is put a little Oleum Arachidis hypogaeae semen, large burn heat after change little fire and decoct 25 minutes, after cooling slowly, it is stand-by firmly to grind to form smalls;
(2) smashed by Os Draconis, be placed in suitable container, on smokeless stove fire, forging is crisp, grinds to form smalls, crosses 100 mesh sieves;
(3) Jasmine tea is placed in clean container, add the hot water of raw material gross weight 11 times, be dipped to the whole variable color of hot water, taken out by Jasmine tea, filtrate is for subsequent use, and the Jasmine tea after immersion and Pericarpium Trichosanthis, Radix Glycyrrhizae, the Radix Astragali and Ganoderma white vinegar are soaked 5 hours, taking-up is placed in low baking temperature on tile and is dried to savory blowing out slowly, dry in the air and be coolly placed in mortar, grind to form fine powder, cross 90 mesh sieves stand-by;
(4) Pericarpium Zanthoxyli, Radix Bupleuri, Cortex Albiziae and Herba Typhonii gigantei are added in step (3) gained filtrate, mixing, intense fire is fried open, and turns and within 45 minutes at a simmer, adds step (1)-(2) institute's smalls and step (3) gained fine powder, continues slow fire boiling 15 minutes, filter to get filtrate 1, the filtering residue low baking temperature that adds water decocts 50 minutes slowly, filters, obtains filtrate 2, twice filtrate is merged, must filtrate be mixed;
(5) by step (4) gained mixing filtrate, sealing and standing 20 hours, gets supernatant, bottles and obtains Traditional Chinese medicinal aerosol.
Test example in December, 1 2011 in January ,-2014, have 400 patients and use.Inclusion criteria: the patient being diagnosed as pulmonary heart disease, age 40-65 year.400 patients are divided into two large groups at random, experimental group and matched group, experimental group uses embodiment 5 gained Traditional Chinese medicinal aerosol, and matched group uses the medicine (medicine of the conventional therapy such as BaoXin Ningtablet, FUFANG DANSHEN DIWAN pulmonary heart disease) of other drug treatment pulmonary heart disease.Two groups was all 1 course for the treatment of with 5 days, evaluated curative effect after 4 courses for the treatment of.Paper examines symptom, sign Index: (1) cardiopalmus, nervous, appetite recovery situation: cardiopalmus, nervous, cough, appetite obviously treat number; (2) mental status situation; (3) stable disease situation: data based on each group conditions of patients average before getting treatment, after treatment cycle terminates, again gets each group of conditions of patients average and compares with data before treatment; (4) other index curative effect situation criterion of health: 1, cure: symptom disappears completely; 2, effective: cardinal symptom obviously alleviates, and health indices recovers to some extent; 3, invalid: compared with before treatment, each side is all without obviously progressive.
Table 1: before and after two groups of treatments, Clinical symptom and sign evaluation situation compares
Observation item time stable disease situation (%) cardiopalmus, nervous, cough, appetite treatment situation (people)
Note: stable disease percent and cardiopalmus in upper table, have palpitation, cough, appetite treats situation data and all takes the mean.
Result: before and after two groups of treatments, Clinical symptom and sign evaluation situation compares, and after treatment, two groups of patients, 2 curative effect indexs are treated all to some extent, and experimental group therapeutic effect is obviously better than matched group.
Table 2: two groups of Clinical efficacy comparisons [example (%)]
Group case load clinical cure enabledisable cure rate total effective rate
| Group | Case load | Clinical cure | Effectively | Invalid | Cure rate | Total effective rate |
| Experimental group | 200 | 192 | 6 | 2 | 96％ | 99％ |
| Matched group | 200 | 140 | 20 | 40 | 70％ | 80％ |
Result: two groups of Clinical efficacy comparisons, matched group cure rate is 70%, and total effective rate is 80%; Experimental group cure rate is 96%, and total effective rate is that 99%, two groups of Clinical efficacy comparisons show that experimental group curative effect is better than matched group.Prove through clinical trial, use Traditional Chinese medicinal aerosol of the present invention, nervous, the cardiopalmus can treating that pulmonary heart disease brings fast and effectively, the symptom of cough, comparatively comprehensively can treat pulmonary heart disease, reaching the object of reduction of patient misery, conditioning patient body, is a kind of Traditional Chinese medicinal aerosol for the treatment of pulmonary heart disease safely and effectively.
The Traditional Chinese medicinal aerosol of remissive treatment acute episode of cor pulmonale by combination, wherein Jasmine tea and Gallus Domesticus are combined and do monarch, and ministerial drug is Os Draconis, Pericarpium Trichosanthis, Radix Glycyrrhizae and the Radix Astragali, and remaining is adjuvant drug; Monarch drug carries attending effectiveness in the present invention, and all having nourishes heart promotes blood circulation, effect of relieving constipation; Ministerial drug is the medicine that auxiliary monarch drug strengthens the main disease for the treatment of and main symptom; Adjuvant drug treatment is held concurrently disease, slows down the strong of monarch drug and ministerial drug; Medicine is made to play a part guiding drug.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. treat the Traditional Chinese medicinal aerosol of acute episode of cor pulmonale by combination, it is characterized in that: each crude drug is as follows, is weight portion: Jasmine tea 30-60, Os Draconis 1-7, Ilisha elongata 5-9, Pericarpium Trichosanthis 1-6, Pericarpium Zanthoxyli 6-9, Radix Glycyrrhizae 2-7, Radix Bupleuri 3-8, Cortex Albiziae 1-5, Radix Astragali 5-15, Gallus Domesticus 8-18, Ganoderma 1-5, Herba Typhonii gigantei 5-10.
2. the Traditional Chinese medicinal aerosol for the treatment of acute episode of cor pulmonale by combination according to claim 1, is characterized in that: each crude drug is as follows, is weight portion: Jasmine tea 40-50, Os Draconis 3-5, Ilisha elongata 6-8, Pericarpium Trichosanthis 2-5, Pericarpium Zanthoxyli 7-8, Radix Glycyrrhizae 3-6, Radix Bupleuri 4-7, Cortex Albiziae 2-4, Radix Astragali 8-13, Gallus Domesticus 10-16, Ganoderma 2-4, Herba Typhonii gigantei 6-9.
3. the Traditional Chinese medicinal aerosol for the treatment of acute episode of cor pulmonale by combination according to claim 1, is characterized in that: each crude drug is as follows, is weight portion: Jasmine tea 45, Os Draconis 4, Ilisha elongata 7, Pericarpium Trichosanthis 3, Pericarpium Zanthoxyli 7.5, Radix Glycyrrhizae 5, Radix Bupleuri 6, Cortex Albiziae 3, the Radix Astragali 10, Gallus Domesticus 14, Ganoderma 3, Herba Typhonii gigantei 7.
4. the preparation method of the Traditional Chinese medicinal aerosol according to any one of claim 1-3, is characterized in that: step is as follows:
(1) decaptitated by Gallus Domesticus and bone, the block that blackbone Chicken is cut into soybean grain size is put on iron plate together with the Ilisha elongata of cutting into inch strips, and iron plate is put a little Oleum Arachidis hypogaeae semen, large burn heat after change little fire and decoct 15-30 minute slowly, after cooling, it is stand-by firmly to grind to form smalls;
(2) smashed by Os Draconis, be placed in suitable container, on smokeless stove fire, forging is crisp, grinds to form smalls, crosses 80-120 mesh sieve;
(3) Jasmine tea is placed in clean container, add raw material gross weight 9-13 hot water doubly, be dipped to the whole variable color of hot water, taken out by Jasmine tea, filtrate is for subsequent use, the Jasmine tea after immersion and Pericarpium Trichosanthis, Radix Glycyrrhizae, the Radix Astragali and Ganoderma white vinegar is soaked 3-7 hour (preferably 5 hours), taking-up is placed in low baking temperature on tile and is dried to savory blowing out slowly, dry in the air and be coolly placed in mortar, grind to form fine powder, cross 80-100 mesh sieve stand-by;
(4) Pericarpium Zanthoxyli, Radix Bupleuri, Cortex Albiziae and Herba Typhonii gigantei are added in step (3) gained filtrate, mixing, intense fire is fried open, and turns 30-60 at a simmer minute and adds step (1)-(2) institute's smalls and step (3) gained fine powder, continue slow fire boiling 10-20 minute, filter to get filtrate 1, the filtering residue low baking temperature that adds water decocts 40-60 minute slowly, filters, obtains filtrate 2, twice filtrate is merged, must filtrate be mixed;
(5) by step (4) gained mixing filtrate, sealing and standing 15-25 hour, gets supernatant, bottles and obtains Traditional Chinese medicinal aerosol.
5. the preparation method of Traditional Chinese medicinal aerosol according to claim 4, is characterized in that: step (1) changes little fire and decocts slowly 18-28 minute (preferred, to change little fire and decoct 25 minutes slowly after large baked wheaten cake heat) after burning heat greatly.
6. the preparation method of Traditional Chinese medicinal aerosol according to claim 4, is characterized in that: step (2) smalls crosses 90-110 mesh sieve (preferred, smalls crosses 100 mesh sieves).
7. the preparation method of Traditional Chinese medicinal aerosol according to claim 4, is characterized in that: step (3) adds raw material gross weight 10-12 hot water doubly (preferred, to add the hot water of raw material gross weight 11 times).
8. the preparation method of Traditional Chinese medicinal aerosol according to claim 4, it is characterized in that: the Jasmine tea after immersion and Herba Apocyni veneti, Radix Notoginseng, the Radix Astragali and Caulis et Folium Chrysanthemi segeti white vinegar soak 4-6 hour (preferred, the Jasmine tea after immersion and Herba Apocyni veneti, Radix Notoginseng, the Radix Astragali and Caulis et Folium Chrysanthemi segeti white vinegar are soaked 5 hours) by step (3).
9. the preparation method of Traditional Chinese medicinal aerosol according to claim 4, is characterized in that: step (4) the filtering residue low baking temperature that adds water is decocted 45-55 minute (preferred, the filtering residue low baking temperature that adds water decocts 50 minutes slowly) slowly.
10. the preparation method of Traditional Chinese medicinal aerosol according to claim 4, is characterized in that: step (5) mixing filtrate sealing and standing 18-23 hour (preferred, mixing filtrate sealing and standing 20 hours).
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| CN1557410A (en) * | 2004-01-14 | 2004-12-29 | 胡惠平 | Chinese medicine composition prescription for treating pulmonary heart disease and its preparation process |
| JP2010280816A (en) * | 2009-06-04 | 2010-12-16 | Kaneka Corp | Method for producing silylated basket-formed silicic acid, and silylated basket-formed silicic acid and polyhedron-structured polysiloxane modified material obtained therefrom |
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| CN1557410A (en) * | 2004-01-14 | 2004-12-29 | 胡惠平 | Chinese medicine composition prescription for treating pulmonary heart disease and its preparation process |
| JP2010280816A (en) * | 2009-06-04 | 2010-12-16 | Kaneka Corp | Method for producing silylated basket-formed silicic acid, and silylated basket-formed silicic acid and polyhedron-structured polysiloxane modified material obtained therefrom |
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