CN104435162A - 治疗病毒性肺炎的内服中药制剂 - Google Patents

治疗病毒性肺炎的内服中药制剂 Download PDF

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CN104435162A
CN104435162A CN201410609255.8A CN201410609255A CN104435162A CN 104435162 A CN104435162 A CN 104435162A CN 201410609255 A CN201410609255 A CN 201410609255A CN 104435162 A CN104435162 A CN 104435162A
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景东旭
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Abstract

本发明公开了一种用于治疗病毒性肺炎的内服中药制剂，其特征在于，选择的中药原料及重量份分别是：板蓝根15份、连翘12份、干葛根15份、白菊花12份、甘草6份、蒲公英10份、桑叶9份、大青叶15份、金银花24份、茯苓12份、赤芍6份、羊蹄草15份。本发明所选用的原料药材药性效互补，规避了药物之间配伍的相恶、相畏、相杀之选，使药物相须、相使作用显著，具有提高免疫力，宣肺化痰，清热解毒作用。具有清理肺热、解毒祛湿、抗病毒功效，内服治疗病毒性肺炎，具有确切疗效。

Description

治疗病毒性肺炎的内服中药制剂
技术领域
本发明涉及中药制剂领域，具体涉及一种用于治疗病毒性肺炎的内服中药制剂。
背景技术
病毒性肺炎是由上呼吸道病毒感染、向下蔓延所致的肺部炎症。本病一年四季均可发生，但大多见于冬春季节，可暴发或散发流行。临床主要表现为发热、头痛、全身酸痛、干咳及肺浸润等。病毒性肺炎的发生与病毒的毒力、感染途径以及宿主的年龄、免疫功能状态等有关。一般小儿发病率高于成人。急性呼吸道感染中，病毒感染占90％，而病毒感染则以上呼吸道为主，有普通感冒、咽炎、喉-气管-支气管炎、细支气管炎、婴儿疱疹性咽峡炎以及流行性胸痛等。引起肺炎的病毒不多见，其中以流行性感冒病毒为常见，其他为副流感病毒、巨细胞病毒、腺病毒、鼻病毒、冠状病毒和某些肠道病毒。婴幼儿还常由呼吸道合胞病毒感染产生肺炎。病毒性肺炎多发生于冬春季节，可散发流行或暴发。本病临床表现一般较轻，与支原体肺炎的症状相似。起病缓慢，有头痛、乏力、发热、咳嗽、并咳少量黏痰。体征往往缺如。X线检查肺部炎症呈斑点状、片状或均匀的阴影。白细胞总数可正常、减少或略增加。病程一般为1～2周。在免疫缺损的患者，病毒性肺炎往往比较严重，有持续性高热、心悸、气急、发绀、极度衰竭，可伴休克、心力衰竭和氮质血症。由于肺泡间质和肺泡内水肿，严重者可发生呼吸窘迫综合征。
发明内容：
本发明的目的在于提供一种用于治疗病毒性肺炎的内服中药制剂，具有清理肺热、解毒祛湿、抗病毒的功效。内服，可以用于病毒性肺炎的治疗，具有确切疗效。
为实现上述目的本发明采用了如下的技术方案：本发明所述中药制剂选择的药材及重量份分别是：板蓝根15份、连翘12份、干葛根15份、白菊花12份、甘草6份、蒲公英10份、桑叶9份、大青叶15份、金银花24份、茯苓12份、赤芍6份、羊蹄草15份。
本发明选择的中药原料中：板蓝根：菘蓝根含靛蓝，靛玉红，蒽醌类、β-谷甾醇，γ-谷甾醇以及多种氨基酸：精氨酸，谷氨酸，酪氨酸，脯氨酸，缬氨酸，γ-氨基丁酸。还含黑芥子甙，靛甙，色胺酮，1-硫氰酸-2-羟基丁-3-烯，蔗糖和含有12％氨基酸的蛋白多糖。【功效】清热，解毒，凉血，利咽。【主治】温毒发斑；高热头痛；大头瘟疫；舌绛紫暗，烂喉丹痧；丹毒；痄腮；喉痹；疮肿、痈肿；水痘；麻疹；肝炎；流行性感冒，流脑，乙脑，肺炎，神昏吐衄，咽肿，火眼，疮疹；可防治流行性乙型脑炎、急慢性肝炎、流行性腮腺炎、骨髓炎。
连翘：【化学成分】果实含连翘酚、甾醇化合物、皂甙(无溶血性)及黄酮醇甙类、马苔树脂醇甙等。抗菌作用连翘浓缩煎剂在体外有抗菌作用，可抑制伤寒杆菌、副伤寒杆菌、大肠杆菌、痢疾杆菌、白喉杆菌及霍乱弧菌、葡萄球菌、链球菌等。【功用主治】清热解毒，消肿散结，疏散风热，有“疮家圣药”之称。治温热，丹毒，斑疹，痈疡肿毒，瘰疬，小便淋闭，清心火。
干葛根：干葛根是豆科植物葛的干燥块根，有升阳解肌，透疹止泻，除烦止温的功效。
白菊花：有效疏散风热、平肝明日、清热解毒的功效，白菊花有治疗风热感冒、发热头痛、目赤昏花、肝肾不足、目暗昏花、眩晕惊风的作用。性味：辛、甘、苦，微寒；归经：归肺、肝经。功效：效疏散风热，平肝明目，清热解毒。主治：风热感冒，发热头痛，目赤昏花，肝肾不足，目暗昏花，眩晕惊风，治肝阳上亢，头痛眩晕，善疏风清热，清肝泻火，兼能益阴明目，故可用治肝经风热，或肝火上攻所致目赤肿痛，共奏疏风清肝明目之效；清热解毒，尤善解疔毒，故可用治疔疮肿毒。
甘草：性平，味甘。功能主治：补脾益气，清热解毒，祛痰止咳，缓急止痛，调和诸药。用于脾胃虚弱，倦怠乏力，心悸气短，咳嗽痰多，脘腹、四肢挛急疼痛，痈肿疮毒，缓解药物毒性、烈性，甘草补脾益气，止咳润肺，缓急解毒，调和百药。
蒲公英：【性味功能】：甘，微苦，寒。清热解毒，消肿散结。【主治】：上呼吸道感染，眼结膜炎，流行性腮腺炎，高血糖，乳痈肿痛，胃炎，痢疾，肝炎，胆襄炎，急性阑尾炎，泌尿系感染，盆腔炎，痈疖疔疮，咽炎，治急性乳腺炎，淋巴腺炎，瘰疠，疔毒疮肿，急性结膜炎，感冒发热，急性扁桃体炎，急性支气管炎、尿路感染。含蒲公英甾醇(Taraxasterol)、胆碱(Choline)、菊糖(Inulin)、果胶(Pectin)；蒲公英醇(Taraxol)、豆甾醇(Stigmasterol)、β-香树脂醇(β-Amyrin)、β-谷甾醇(β-Sitosterol)、蒲公英赛醇(taraxerol)、蒲公英素(Taraxacerin)、蒲公英苦素(Taraxacin)和维生素A、B、C等。
桑叶：桑叶是桑科植物桑的干燥叶，又名家桑、荆桑、桑椹树、黄桑等，全国大部分地区多有生产，具有降血压、血脂、抗炎等作用；富含稀有元素有机硒、锗，是天然的强抗氧化剂，可清除体内自由基，使蓄积在人体内的毒素和废物被氧化，增加血液中的含氧量，促进新陈代谢和微循环。对于高血脂、高血糖、脂肪肝、冠心病、高血压、甲、乙型肝炎的治疗以及癌症术后放化疗病人的康复有非常好的辅助作用。功效：疏散风热；清肺；明目。主风热感冒；风温初起，发热头痛，汗出恶风，咳嗽胸痛；或肺燥干咳无痰；咽干口渴；风热及肝阳上扰；目赤肿痛。用于风热感冒，肺热燥咳，头晕头痛，目赤昏花。
大青叶：清热，解毒，凉血，止血。治温病热盛烦渴，流行性感冒，急性传染性肝炎，菌痢，急性胃肠炎，急性肺炎，丹毒，吐血，衄血，黄疸，痢疾，喉痹，口疮，痈疽肿毒。
金银花：【性味归经】味甘；寒。归肺；胃经。【功效主治】清热解毒。温病发热；热毒血痢；痈肿疔疮；喉痹及多种感染性疾病。
茯苓：性味甘淡平，入心、肺、脾经。具有渗湿利水，健脾和胃，宁心安神的功效。能增强机体免疫功能，茯苓多糖有明显的抗肿瘤及保肝脏作用。可治小便不利，水肿胀满，痰饮咳逆，呕逆，恶阻，泄泻，遗精，淋浊，惊悸，健忘等症。茯苓之利水，是通过健运脾肺功能而达到的，与其它直接利水的中药不同。
赤芍：功能，行瘀、止痛、凉血、消肿。主治：治瘀滞经闭、疝瘕积聚、腹痛、胁痛、衄血、血痢、肠风下血、目赤、痈肿、跌扑损伤。
羊蹄草：味微苦，性凉。功能清热解毒，散瘀消肿，凉血。主治上呼吸道感染、急性扁桃体炎、口腔溃疡、急性结膜炎、肺炎、胆囊炎、传染性肝炎、钩端螺旋体病、急性阑尾炎、盆腔炎、睾丸炎、菌痢、肠炎、便血、尿路感染、肾炎等证。外用鲜品捣敷，对痈疮疖肿、皮炎、湿疹、跌打损伤，有散瘀消肿、拔毒止痒之效。
本发明所选用的原料药材药性效互补，规避了药物之间配伍的相恶、相畏、相杀之选，使药物相须、相使作用显著，具有提高免疫力，宣肺化痰，清热解毒作用。具有清理肺热、解毒祛湿、抗病毒功效，是治愈病毒性肺炎的内服纯中草药组成制剂。临床应用时具有良好的确切效果。
病毒性肺炎的治疗目前探讨不一，近年来我根据数十年的”临床经验，结合独到的用药体会，应用现代药物制备工艺研制出治愈病毒性肺炎的内服纯中药制剂，具有确切疗效。由于其应用效果良好，且不易由现有技术的化合物预见到，西医疗效亦不如中草药疗效，故将有效治愈病毒性肺炎的内服纯中草药组成制剂开发出来，能应用于临床，为更多的患者解除痛苦。
本发明药物可以采用中药制剂的常规方法制备成任何常规内服制剂。例如可以将这些原料药研成粉末混合均匀散剂冲服；可以将这些原料药一起水煎，然后浓缩煎液服用，或者把浓缩煎液浓缩成膏加工成丸剂服用；为了使该药物的各原料更好地发挥药效，针对某原料药进行特殊提取，如乙醇提取，这些不能用于限制本发明的保护范围。
本发明所述药物具有清理肺热、解毒祛湿、抗病毒功效，用于治疗病毒性肺炎。本发明人经过反复研究，并通过临床试验的反复验证，终于找到了有更好疗效的内服药物，从而完成了本发明。
临床药效试验材料及典型病例：
郑XX，女，16岁。初诊日期2013年5月23日。患者于2013年4月25日开始高热，经肌内注射阿尼利安、口服退热药和头孢素2日后症状好转。但10日后高热再次复起，体温40℃，左肺叶呼吸音较低。西医诊断为病毒性肺炎。经住某医院用多种抗生素和输液治疗了11日，体温仍持续在40℃，且伴有头痛纳呆，周身疲乏无力，与5月23日前来就诊。查体见：大便秘结，小便黄赤，舌质红、苔黄燥，脉浮数。此属风热犯肺，肺气不宣，郁久热邪化毒。随投以本发明方剂10剂，做汤剂内服。
方法和有效量：板蓝根15份、连翘12份、干葛根15份、白菊花12份、甘草6份、蒲公英10份、桑叶9份、大青叶15份、金银花24份、茯苓12份、赤芍6份、羊蹄草15份；取处方规定量中药材饮片，置适宜煎煮器中，加入清水适量，浸泡适宜时间，加热至沸，保持微沸状态一定时间(约25～30分钟)，分离煎出液，药渣再加水适量煎煮，按规定煎煮2～3次后，合并煎出液，过滤或沉降分离煎出液供使用。
汤剂内服为主，每日早晚2次内服，每次150ml温服。汤剂则作用快而力峻，适应于病情较急重者。如病情较轻或缓者，宜为丸剂内服求其功。
具体实施方式
所述用于治疗病毒性肺炎的内服中药制剂，其特征在于，选择的中药原料及重量份分别是：板蓝根15份、连翘12份、干葛根15份、白菊花12份、甘草6份、蒲公英10份、桑叶9份、大青叶15份、金银花24份、茯苓12份、赤芍6份、羊蹄草15份；
制备方法：取板蓝根15份、连翘12份、干葛根15份、白菊花12份、甘草6份、蒲公英10份、桑叶9份、大青叶15份、金银花24份、茯苓12份、赤芍6份、羊蹄草15份；分别制成饮片，经过高压锅蒸煮杀菌30-60分钟，晾干，获得无菌原材料，进行密封包装，获得商品中药制剂饮品。

Claims (1)

1.用于治疗病毒性肺炎的内服中药制剂，其特征在于，选择的中药原料及重量份分别是：板蓝根15份、连翘12份、干葛根15份、白菊花12份、甘草6份、蒲公英10份、桑叶9份、大青叶15份、金银花24份、茯苓12份、赤芍6份、羊蹄草15份；
其制备方法：取板蓝根15份、连翘12份、干葛根15份、白菊花12份、甘草6份、蒲公英10份、桑叶9份、大青叶15份、金银花24份、茯苓12份、赤芍6份、羊蹄草15份；分别制成饮片，经过高压锅蒸煮杀菌30-60分钟，晾干，获得无菌原材料，进行密封包装，获得商品中药制剂饮品。
CN201410609255.8A 2014-10-27 2014-10-27 治疗病毒性肺炎的内服中药制剂 Pending CN104435162A (zh)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111658703A (zh) * 2020-07-17 2020-09-15 汉方泰药生物科技(宁波)有限公司 一种加快肺炎患者恢复的中药

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111658703A (zh) * 2020-07-17 2020-09-15 汉方泰药生物科技(宁波)有限公司 一种加快肺炎患者恢复的中药

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