CN104432000A - Sleep improving health-care food and preparation method thereof - Google Patents

Sleep improving health-care food and preparation method thereof Download PDF

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Publication number
CN104432000A
CN104432000A CN201310426281.2A CN201310426281A CN104432000A CN 104432000 A CN104432000 A CN 104432000A CN 201310426281 A CN201310426281 A CN 201310426281A CN 104432000 A CN104432000 A CN 104432000A
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health
extract
water
care food
fruit
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魏建和
杨美华
赵祥升
齐云
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Institute of Medicinal Plant Development of CAMS and PUMC
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Institute of Medicinal Plant Development of CAMS and PUMC
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105Plant extracts, their artificial duplicates or their derivatives

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  • Life Sciences & Earth Sciences (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The present invention discloses a sleep improving health-care food and a preparation method thereof, which belong to the health-care food industry. The sleep improving health-care food is composed of the following raw materials (parts by weight): 1-5 Sharpleaf Galangal fruits, 5-15 spine date seeds, 1-5 schisandra chinensis and 1-5 Ganoderma Lucidum. The health-care food preparation method consists of the following steps: extracting the Sharpleaf Galangal fruits, the spine date seeds and the schisandra chinensis by refluxing with ethanol and extracting Ganoderma Lucidum by hot refluxing, and obtaining a mixed extract; concentrating the extract under reduced pressure and recycling the ethanol in the extract to obtain a refined flow paste for production use; mixing the flow paste with ingredients in an appropriate proportion, granulating the mixed materials, drying, finish granulating and packaging the granulation, and obtaining the finished products. The raw materials selected in the health-care food belong to the medicinal and edible items stipulated by the Ministry of Health, and are non-toxic or non-harmful to humans, and thus the health-care food can improve sleep quality in the middle aged and elderly people.

Description

A kind of health food of improving water flood and preparation method
Technical field
The present invention relates to a kind of health food of improving water flood, be a kind of health products being raw material with the Chinese herbal medicine of medicine-food two-purpose of improving water flood, belong to field of health care products.Another object of the present invention is to provide the preparation method of these health products.
Background technology
Sleep is the important content of human life activity, closely bound up with the life and health of people, and healthy important leverage is not only in good sleep, is also the normal portrayal of body function activity simultaneously.In Mawangdui medical book " ten ask ", just there is the discussion of " former times (sunset) does not crouch, one hundred days refuse to obey ", absolutely proved the importance of sleep to people's life, work and health.The present social life rhythm and pace of moving things is more and more faster, and the incidences such as operating pressure strengthens increasingly, poor sleep rise year by year.Go to a doctor at basic medical unit to 25916 examples in 14 countries, 15 bases according to the World Health Organization in 2008 the investigation result display of patient, the people of 27% has sleeping problems, and is diagnosed as the half of patient close to actual diseased number of insomnia.The incidence of China's insomnia especially up to 45.4%, and recognizes that the crowd oneself suffering from insomnia only has 25.9%, and sleeping problems have become the large factor affecting people's particularly the elderly's work, life.In recent years, the treatment for insomnia is more and more subject to people's attention.
The current clinical treatment for insomnia is mostly based on sedative hypnotic medicine, and this kind of medicine of long-term taking can destroy Sleep architecture, produces drug dependence; Meanwhile, medicine is accumulated in vivo for a long time and not only can be caused lassitude, decrease of memory, the bad reaction such as slow in reacting, and can cause hepatorenal damage and gastrointestinal symptom, forms the vicious circle of insomnia.Contrastingly traditional Chinese medicine have accumulated abundant clinical experience in the treatment of sleep-disorder, its sick position is at brain, and its morbidity and the heart, liver, taste, lung, kidney are closely related." Ling Shu Miraculous Pivot or Divine Axis. evil visitor " in explicitly point out: the theory of " supplement not enough, reducing for the excess syndrome, adjusts its actual situation, with Tong Qidao, and eliminating the pathogen "; " gold is deficient. blood-arthralgia consumptive disease " in: " consumptive disease with restlessness must not be slept, suanzaoren decoction master it ", discusses blood deficiency, what consumptive disease was vexed be insomnia disease, still has higher Clinical practice to be worth so far.In modern age, to treatment of sleep disorders, with reinforce insufficiency and reduce excessiveness, adjustment internal organs yang blood and qi is general provisions.Adopt tonifying heart and spleen, nourishing Yin and falling fire, restoring normal coordination between heart and kidney respectively, soothing the liverly to nourish blood, clearing liver cholagogic, clearing heat and eliminating phlegm, clearing damp is reduced phlegm, beneficial gas ballasting is frightened, invigorate the spleen and warm the kidney, beneficial gas activate yang, Zishen fill fine, the therapy such as promoting blood circulation and removing blood stasis and clearing summer-heat and tonifying qi, qi and blood is in harmonious proportion, equilibrium between yin and yang, function recovers normal, the mind can keep house, be insomnia and heal, giving tranquilizing the mind simultaneously.In diagnosis and treatment, while Heibei provincial opera internal organs, negative and positive, qi and blood, selective application nourishing blood and tranquilization, clearing away the heart fire and tranquillizing, educate that the moon is calmed the nerves, benefiting qi for tranquillization, tranquilizing and allaying excitement, cerebral tonic tranquillizing etc. select to the ill.
In recent years, along with people are to the pay attention to day by day of health, Global Health produce market increases fast, and health products trade becomes genuine " large cake ".But China's health-product market exploitation at present mostly concentrates in immunological regulation, adjusting blood lipid, antifatigue 3 (accounting for the 60-70% of whole health products function), and the health products ratio of improving water flood only accounts for 6.79% (2010).From the health products of market sale improving water flood, mainly be developed as master with epiphysin, and be that the health products of the improving water flood of development of raw materials are relatively less with Chinese herbal medicine, thus the health products with improving water flood are developed, improve the production method of Chinese traditional herbs, will inevitably be accepted by the consumer of vast poor sleep, there are good market prospects.
Summary of the invention
The present invention develops in conjunction with latest modern technological achievement in research on the basis of traditional tcm syndrome differentiation and treatment.The object of this invention is to provide a kind of health food and preparation method of improving water flood, there is determined curative effect, safe ready, the feature that has no side effect.
The present invention is made up of the raw material of following weight proportioning:
Fructus alpiniae oxyphyllae 1-5 part, spina date seed 5-15 part, fruit of Chinese magnoliavine 1-5 part, glossy ganoderma 1-5 part.
The weight proportion of optimum formula raw material of the present invention is:
Fructus alpiniae oxyphyllae 3 parts, spina date seed 10 parts, 2 parts, the fruit of Chinese magnoliavine, glossy ganoderma 3 parts.
In above-mentioned raw materials, the fructus alpiniae oxyphyllae property of medicine is pungent, temperature.Return spleen, kidney channel.Warm kidney controlling nocturnal emission with astringent drugs contracting urine, warming spleen and stopping diarrhaly takes the photograph saliva.For enuresis with renal asthenia, frequent urination, seminal emission gonorrhoea, malaria is had loose bowels, crymodynia in abdomen, the many salivas of mouth etc. (" Chinese Pharmacopoeia ", China Medical Science Press, 273 pages); The spina date seed property of medicine is sweet, flat.The thoughts of returning home, Liver Channel.There is antitoxic heart-soothing and sedative, effect of nourishing the liver, arrest sweating.Can treat restlessness of asrhenia type and insomnia, palpitation with fear dreaminess, the empty hidrosis of body, Tianjin wound waits (" Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine writes, the Shanghai science tech publishing house second edition 3579 pages) yearningly; The fruit of Chinese magnoliavine, property of medicine acid, warm in nature.Return lung, the heart, kidney channel.There is convergence astringent or styptic treatment for spontaneous sweating, nourishing generate fluid, effect of antitoxic heart-soothing and sedative.Can treat chronic cough void to breathe heavily, Tianjin wound is thirsty, palpitation and insomnia etc. (" Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine writes, the Shanghai science tech publishing house second edition 520 pages); The glossy ganoderma property of medicine is sweet, flat.Return lung, heart the spleen channel.Have beneficial gas strong, effect of mental-tranquilization, it is thin and weak to treat consumptive disease, poor appetite, palpitaition, insomnia, dizzy, spiritlessness and weakness, chronic cough is panted, coronary heart disease, high blood pressure, high fat of blood, silicosis etc. (" Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine writes, the Shanghai science tech publishing house second edition 1651 pages).These medicine materials are the medicinal material of the integration of drinking and medicinal herbs that health ministry specifies, can make medicine, also can make health food.
The method for making of the health products of improving water flood provided by the invention comprises:
(1) raw materials medicament extracting solution: first fructus alpiniae oxyphyllae, spina date seed, the fruit of Chinese magnoliavine are weighed in proportion, mixing, add the ethanol water of 6 times 80%, 80 DEG C of water-baths extract 3h, extract 3 times, merge 3 gained filtrates, be the extract of fructus alpiniae oxyphyllae, spina date seed and the fruit of Chinese magnoliavine, for subsequent use, filter residue discards; Glossy ganoderma adopts water extraction: proportionally weigh, add the pure water of 15 times, be placed on the water-bath of 90 DEG C, extracts 2h, filters, and filtrate is retained; Filter residue adds the pure water of 10 times, is placed on the water-bath of 90 DEG C, extraction time 1h, and filter, merge 2 gained filtrates, be lucidum extracting liquid, for subsequent use, filter residue discards.
(2) prepare medicinal extract: merge bulk drug extract, adopt the method that pressurization is concentrated, namely concentrate under vacuo, recycling design, then the water-bath being placed in 60 DEG C is concentrated into the medicinal extract that relative proportion is 1.30-1.35, for subsequent use.
(3) prepare particle: get medicinal extract 1 part, (spraying dry, crosses 16 object sieves, whole grain for sucrose: dextrin=1: 1) 4 parts, wet granulation to add auxiliary material.
(4) pack: load aluminium foil bag by after particle ultraviolet disinfection, packaging becomes finished product after the assay was approved.
Health products of the present invention are domestic not containing epiphysin and the pure natural not adding chemical substance at present, and the product of improving water flood is forth generation improving water flood series products, represents the sleep biotechnology achievement of current forefront.This product and method for making thereof tool compared with similar products at home and abroad has the following advantages: be instruct with traditional Chinese medical theory, find in conjunction with modern pharmacology experiment: four traditional Chinese medicine has his own strong points in improving water flood, improving water flood curative effect is given prominence to, and can improve sleep quality from different aspect; Raw material selected by the present invention is all food and medicine consangunity medicinal materials that health ministry specifies, not containing epiphysin and any chemical substance, take these health products without any side effects, without additive, edible safety, is mainly used in the mid-aged population of insomnia and sleep-disorder; Preparation process is simple, and formulation is easy to carry about with one.The present invention is high in technological content, convenient operation, easily forms suitability for industrialized production.
Detailed description of the invention
Preparation method and the effect of health products of the present invention is described in further detail below in conjunction with embodiment and experimental example
Prescription
Fructus alpiniae oxyphyllae 30g, spina date seed 100g, fruit of Chinese magnoliavine 20g, glossy ganoderma 30g, dextrin 60g, cane sugar powder 60g
Preparation method
A, get fructus alpiniae oxyphyllae, spina date seed and Chinese Magnolivine Fruit, add the ethanol water of 6 times 80%, 80 DEG C of water-baths extract 3h, extract 3 times, merge 3 gained filtrates, be the extract of fructus alpiniae oxyphyllae, spina date seed and the fruit of Chinese magnoliavine, for subsequent use, filter residue discards; Get glossy ganoderma medicinal powder, add the pure water of 15 times, be placed on the water-bath of 90 DEG C, extract 2h, filter, filtrate is retained; Filter residue adds the pure water of 10 times, is placed on the water-bath of 90 DEG C, extraction time 1h, and filter, merge 2 gained filtrates, be lucidum extracting liquid, for subsequent use, filter residue discards;
B, merge the filtrate of alcohol extracting and water extraction, solvent recovered under vacuum, the water-bath being then placed in 60 DEG C is concentrated into the medicinal extract that relative proportion is 1.30-1.35, for subsequent use;
C, get fructus alpiniae oxyphyllae, spina date seed, the fruit of Chinese magnoliavine and Ganodenna Lucidum P.E medicinal extract 30g, dextrin and Icing Sugar (1: 1) 120g, fully mix;
D, until both mix time, under stirring, slowly add the appropriate amount of ethanol of 90%, continue to stir, make dry wet suitable softwood;
E, the softwood prepared is joined in oscillating granulator, granulate with the screen cloth of 20 order specifications;
F, the wet granular that makes is sent into baking oven, 50 DEG C of vacuum drying, about 3h.
G, the particle that taking-up vacuum drying is good, treat that its temperature is cooled to room temperature, join in oscillating granulator, and with the whole grain of screen cloth of 16 order specifications, pack, about obtains 100g.
Experimental example
The present invention is for the experimental study of improving water flood function
1, material
1.1 samples: embodiment of the present invention product
1.2 animals: ICR mouse 70, male and female half and half, SPF level, body weight 18-20g.Thered is provided by animal used as test Technology Co., Ltd. of dimension tonneau China.The quality certification number is SCXK (capital) 2012-0001.Animal feeding is in China Medical Sciences Academy Medical Plants Institute SPF level Animal House.
1.3 instruments: electronic scale, electronic balance, stopwatch, YLS-1A Multifunctional mouse autonomic activities recorder (being dispatched from the factory by Shandong Academy of Medical Sciences's equipment station).
1.4 positive control drugs: diazepam injection (diazepam tablet), Beijing Yimin Pharmaceutical Factory, authentication code: No. 154011st, the accurate word (1996) of medicine is defended in capital.Lot number: 0202030.
2, experimental technique
Mouse divides 5 groups at random by body weight, be respectively Normal group, diazepam 1.5mg/kg group, little (1.5g crude drug/the kg of embodiment product, 285mg extract/kg), in (3g crude drug/kg, 570mg extract/kg), (6g crude drug/kg greatly, 1140mg extract/kg) group, administration group respectively gavage gives tested liquid 0.2ml/10g, successive administration 3 days, every day 1 time, Normal group gives the distilled water of same volume, after last administration one hour, mouse is put into the movable number of times that Multifunctional mouse autonomic activities recorder adapts to measure after 5 minutes 10 minutes.
3, experimental result
Table 1: the impact of embodiment Granules on Mouse autonomic activities
Note: represent and compare with normal group, * p≤0.05, * * P < 0.01, show that middle high dose significantly can suppress the autonomous spontaneous activity of mouse, experimental result is positive.
Embodiment presses 3g crude drug/kg, 6g crude drug/continuous three days of kg, 12g crude drug/kg dosage gavage, wherein give mouse benevolence sesame intelligence development 6g crude drug/kg, 12g crude drug/kg dosage group and obviously can reduce mouse spontaneous activity (P < 0.05), be equivalent to the equivalent (0.3g/kg/ day) of 60kg body weight people consumption per day 18g crude drug to mouse benevolence sesame intelligence development 6g crude drug/kg, therefore infer that people's consumption per day 18g can play sedative-hypnotic effect.
The present invention measures (margin of safety test) to maximal tolerance dose (MTD)
1, material
1.1 animal ICR mouse 40, male and female half and half, SPF level, body weight 18-20g.Thered is provided by animal used as test Technology Co., Ltd. of dimension tonneau China.The quality certification number is SCXK (capital) 2012-0001.Animal feeding is in this institute SPF level Animal House.
1.2 tested materials: the dark brown medicinal extract preparing granule.
2, test method
By trial test, find benevolence sesame intelligence development extract 50% concentration with 0.4ml/10g body weight gastric infusion once, after result administration, 10 animals are without death, and in good condition.Therefore formal test is with ICR mouse 40, male and female half and half, fasting 12 hours before test, every mouse stomach tested material 0.4ml/10g, was administered once in one day, and dosage is 105g crude drug/kg/d (20g extract/kg/d).At once observe reaction of animals after administration, outward appearance, four limbs be movable, ingest, drink water, the situation such as excretion, and to observe once every day, continuous 7 days, record the response situation of every animal in detail.Put to death surviving animals time off-test (the 7th day) and carry out dissection inspection.And by following formulae discovery mouse maximal tolerance dose multiple:
3, result of the test
With medicinal extract gastric infusion, after administration, animal is in good condition, without exception, and in all animal observation periods, animal is in good condition, ingests, drinks water without exception, also have no the symptoms of digestive tract such as diarrhoea.Observe at the end of 7 days, do not find animal dead, body weight increases (see table 2) all to some extent, visually observes and has no overt toxicity reaction.Dissect animal after off-test, have no obvious internal organs abnormal.
Table 2: benevolence sesame intelligence development maximum volume Cmax gastric infusion is on the impact of Mouse Weight
Maximal tolerance dose (MTD) measures: test with the tolerant maximum dose of animal (health products 105g crude drug/kg/d or 20g extract/kg/d) that gastric infusion once, Continuous Observation 7 days, at viewing duration, all animals are in good condition, without exception, and body weight increases all to some extent.Intend consumption 18g by benevolence sesame intelligence development clinical Coming-of-Age Day, calculate by adult 60kg body weight, being equivalent to consumption per day is 0.3g/kg body weight, and the MTD of health products is equivalent to 350 times of clinical application amount.Show that these health products have higher security.Conclusion: health products involved in the present invention suppress spontaneous activity in mice result to be positive, and the maximum tolerance test of mouse shows there is higher security, and according to function of health food evaluation criterion, the present invention has the function of improving water flood.

Claims (6)

1. the invention provides a kind of health food of improving water flood, it is characterized in that formula is by integration of drinking and medicinal herbs medicinal material: fructus alpiniae oxyphyllae, spina date seed, the fruit of Chinese magnoliavine, glossy ganoderma form.
2. the health products of a kind of improving water flood according to claim 1, wherein the weight proportion of each raw material is:
Fructus alpiniae oxyphyllae 1-5 part, spina date seed 5-15 part, fruit of Chinese magnoliavine 1-5 part, glossy ganoderma 1-5 part.
3. the health products of a kind of improving water flood according to claim 1, wherein the proportioning of the weight optimal amount of each raw material is as follows:
Fructus alpiniae oxyphyllae 3 parts, spina date seed 10 parts, 2 parts, the fruit of Chinese magnoliavine, glossy ganoderma 3 parts.
4. keep healthy method for making as claimed in claim 1, and its feature comprises:
(1) raw materials medicament extracting solution: first fructus alpiniae oxyphyllae, spina date seed, the fruit of Chinese magnoliavine are weighed in proportion, mixing, add the ethanol water of 6 times 80%, 80 DEG C of water-baths extract 3h, extract three times, merge three gained filtrates, be the extract of fructus alpiniae oxyphyllae, spina date seed and the fruit of Chinese magnoliavine, for subsequent use, filter residue discards; Glossy ganoderma adopts water extraction: proportionally weigh, add the pure water of 15 times, be placed on the water-bath of 90 DEG C, extracts 2h, filters, and filtrate is retained; Filter residue adds the pure water of 10 times, is placed on the water-bath of 90 DEG C, extraction time 1h, and filter, merge twice gained filtrate, be lucidum extracting liquid, for subsequent use, filter residue discards.
(2) prepare medicinal extract: merge raw material extracts, adopt the method for reduced pressure concentration, namely concentrate under vacuo, recycling design, then the water-bath being placed in 60 DEG C is concentrated into the medicinal extract that relative proportion is 1.30-1.35, for subsequent use.
(3) prepare particle: get medicinal extract 1 part, (spraying dry, crosses 16-20 object sieve, whole grain for sucrose: dextrin=1: 1) 4 parts, wet granulation to add auxiliary material.
(4) pack: load aluminium foil bag by after particle ultraviolet disinfection, packaging becomes finished product after the assay was approved.
5. as right 3 require as described in health products method for making, it is characterized in that fructus alpiniae oxyphyllae, the concentration of spina date seed and fruit of Chinese magnoliavine ethanol when extracting at 70%-90%, solid-liquid ratio 4-6 doubly, extraction time 1-3 time, extraction time 1-3 time; When glossy ganoderma is extracted, solid-liquid ratio is 1: 10-1: 20, and extraction time is 1-2h, and extraction time is 1-3 time, and Extracting temperature is 90 DEG C; When medicinal extract concentrates, vacuum degree control is at 0.07-0.08MPa, concentration time 5-8h, and the relative proportion of medicinal extract is 1.30-1.35; During granulation, the ratio of medicinal extract and auxiliary material is 1: 1-1: 5, and auxiliary material is pure sucrose or dextrin, and the ratio of dextrin and sucrose amount is 1: 1-1: 3.
6., according to right 1, there is described in 3 requirements the preparation method of the health products of improving water flood, it is characterized in that can also making the forms such as tablet, oral liquid, pill, capsule as required.
CN201310426281.2A 2013-09-18 2013-09-18 Sleep improving health-care food and preparation method thereof Pending CN104432000A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112772748A (en) * 2021-03-10 2021-05-11 江西仙客来生物科技有限公司 Preparation method of ganoderma Lushan mist tea

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