CN104430466A - Water emulsion composition for preventing and treating rice sheath blight and preparation method thereof - Google Patents
Water emulsion composition for preventing and treating rice sheath blight and preparation method thereof Download PDFInfo
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- CN104430466A CN104430466A CN201410681360.2A CN201410681360A CN104430466A CN 104430466 A CN104430466 A CN 104430466A CN 201410681360 A CN201410681360 A CN 201410681360A CN 104430466 A CN104430466 A CN 104430466A
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- aqueous emulsion
- thifluzamide
- prochloraz
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Abstract
The invention discloses a water emulsion composition for preventing and treating the rice sheath blight and a preparation method thereof, and belongs to the technical field of agricultural fungicide preparations. According to the antiseptic water emulsion composition, prochloraz and thifluzamide are adopted to be combined to realize the purpose of synergistic interaction; by adopting the water emulsion and the preparation method thereof, the feeding sequence, operation and the like are optimized, and the conventional preparation technology is improved; the water emulsion composition is used for preventing and treating the rice sheath blight, can delay bacteria resistance, further improves the prevention and treatment effect, reduces the dosage of pesticides, reduces pesticide residue, and reduces environmental pollution.
Description
Technical field
The invention belongs to agricultural bacteriocide preparation technique field, specifically relate to composition aqueous emulsion of a kind of water prevention rice sheath blight and preparation method thereof.
Background technology
Rice sheath blight disease is also known as moire disease, and popular name spends sufficient stalk, rotten pin pest, features spot.Be infected by Rhizoctonia solani Kuhn to fall ill, how occur under high temperature, super-humid conditions.Banded sclerotial blight causes harm seriously in South Rice Region of China, is one of Major Diseases in current Rice Production.This disease makes paddy rice not ear, or the not plump paddy of heading is more, and grain heavily declines.
Prochloraz chemical name: N-propyl group-N-[2-(2,4,6-Trichlorophenoxy) ethyl]-imidazoles-1-formamide, former medicine is light tan solid, has fragranced, is insoluble in water, is soluble in acetone, ethanol, dimethylbenzene equal solvent.For imidazoles wide spectrum low toxicity bactericide, there is protection and eradicant action.Work by suppressing the biosynthesis of sterol, finally cause germ dead, the multiple diseases preventive effect caused for sac fungi and imperfect fungus is splendid.Without systemic action, there is certain conduction.
Thifluzamide is again thiophene fluorine bacterium amine, the full fringe of trade name.Belong to thiazole amide bactericide, there is strong Uptake and translocation and long lasting effect.It is the phenyl amide compound containing thiazole ring, and can prevent and treat various crop disease, particularly the fungus-caused disease of basidiomycetes Rhizoctonia has good control efficiency.Its Main Function mechanism suppresses succinic acid dehydrogenase in germ tricarbonic acid cycle, causes thalline dead.Thifluzamide is succinate dehydrogenase inhibitor, and due to fluorine-containing, its its competitiveness in biochemical pathway is very strong, just not easily recovers once be combined with substrate or enzyme.Thifluzamide all has activity to pathomycetes such as Rhizoctonia, Puccinia, Ustilago, Tilletia, corticium, nuclear cavity Pseudomonas, especially has special efficacy to the fungus-caused disease of Basidiomycetes such as banded sclerotial blight, damping off etc.
Summary of the invention
The present invention be directed to above-mentioned Problems existing and provide a kind of its aqueous emulsion of bactericidal composition for the water prevention rice sheath blight and preparation method thereof; Prochloraz and thifluzamide is adopted to carry out composite; play the object of Synergistic; and improve original preparation technique; for the water prevention rice sheath blight; to crops, there is protection and therapeutic action; said composition can delay germ pesticide resistance; and reduce the usage amount of medicine; reduce residue of pesticide; the pesticide resistance of further reduction germ, also reduces the pollution to environment.
Bactericidal composition technical scheme of the present invention is comprise Prochloraz and thifluzamide, and weight ratio is Prochloraz: thifluzamide=1-10:1-10.
Be 1:1 as preferably described Prochloraz and thifluzamide weight ratio.
The aqueous emulsion of bactericidal composition of the present invention, comprises following component by weight: Prochloraz 1-10%, thifluzamide 1-10%, emulsifier 5-15%, cosolvent 5-20%, antifreezing agent 3-7%, defoamer 0.5-3%, thickener 0-2.5%, and surplus is water.
Described cosolvent is one or both in toluene, dimethylbenzene, solvent naphtha, cyclohexanone, dimethyl formamide, ethyl acetate, acetone or vegetable oil.
Described emulsifier can select nonionic surface active agent or anionic surfactant.
Described non-ionic surface active agent is one or more in phenethyl phenol polyethenoxy ether, phenethyl phenol polyethenoxy polyethenoxy ether, alkylphenol polyoxyethylene, alkylphenol polyoxyethylene formaldehyde condensation products, fatty alcohol-polyoxyethylene ether, castor oil polyoxyethylene ether, polystyrene-based phenol formaldehyde resin APEO, phenethyl phenol polyethenoxy ether phosphate or alkylphenol polyoxyethylene phosphate; Described anion surfactant is one or more in alkyl benzene calcium sulfonate, sodium alkyl benzene sulfonate or C8-C20 sodium alkyl sulfate.
Described antifreezing agent is one or more in ethylene glycol, propane diols, glycerine, polyethylene glycol, sorbierite or urea.
Described defoamer is organic silicone oil or isooctanol.
Described thickener is one or more in xanthans, gum Arabic, carboxymethyl cellulose, CMC or polyvinyl alcohol.
The preparation method of aqueous emulsion of the present invention, its step is as follows: Prochloraz and thifluzamide cosolvent are dissolved, add emulsifier, antifreezing agent, defoamer stir as oil phase, being added to the water by thickener stirs as aqueous phase, under 1000-2000r/min stirs oil phase added aqueous phase or aqueous phase adds oil phase, then under 4000-5000r/min, high-speed circulating shears 30-50min, and obtain aqueous emulsion product, its average grain diameter is below 10 microns.
Water of the present invention is running water or ionized water, preferred running water.
Beneficial effect of the present invention is: bactericidal composition of the present invention adopt Prochloraz and thifluzamide two kinds of active ingredients composite, play the object of Synergistic, control efficiency for Rhizoctonia solani Kuhn is good, improve actual control efficiency, and by composite can expanding prevention general, reduce the usage amount of medicine, thus greatly delay the generation of germ pesticide resistance, prevent the generation of vicious circle.The reduction of same drug use amount, residue of pesticide are few, Product Green environmental protection, little to the injury of people and animals etc., meet the developing direction of society.In the formulations of pesticide, adopt aqueous emulsion agent, product active constituent content is high, aqueous emulsion is water base chemical preparation, not containing a large amount of organic solvents, production process is without dust, without the three wastes, environmental pollution is little, energy consumption is low, adopts the composition of no oil phase, aqueous phase, adopts the charging sequence and operation etc. of optimization in preparation method, further increase control efficiency, also indirectly play the effect delaying germ pesticide resistance and reduce residue of pesticide, be supplementing bactericidal composition, make the better effects if of said composition.
With mycelial growth rate method have studied Prochloraz, thifluzamide different ratio mixture to the indoor virulence of Rhizoctonia solani Kuhn, experimental technique adopts the abundant method of Sun Yun to calculate co-toxicity coefficient (CTC) and evaluates mixed effect, thinks that mixture has synergistic effect when CTC value is greater than 120.Concrete grammar is as follows:
Get the liquid prepared and be placed in 100ml 50-60 DEG C of PDA sterilising medium, shake up, pour in the sterilizing culture dish of diameter 60mm, after cooled and solidified, move the bacterium cake that length is consistent, diameter is 4mm of delivering a child respectively, to add the sterilising medium of equivalent coordinative solvent as blank, all operations all carries out sterile working at superclean bench, and often 3 repetitions are established in process.Put into after 27 DEG C of constant incubators cultivate 3-8 days, adopt right-angled intersection method to measure colony diameter, calculate bacteriostasis rate, EC
50, the relevant parameter such as CTC, relevant calculating formulas is as follows:
Pure amount of growth=bacterium colony average diameter-bacterium cake diameter (0.4cm)
Bacteriostasis rate=[the pure amount of growth of (contrast pure amount of growth-process pure amount of growth) × 100/ contrast] × 100%
The EC50*100 of the EC50/B agent of toxicity index TI (B)=standard agent A
The EC50*100 of the EC50/AB of actual toxicity index ATI (AB)=A
Theoretical toxicity index TTI (AB)=percentage+TI (B) the * B percentage in mixture of TI (A) * A in mixture
Co-toxicity coefficient CTC=ATI (AB)/TTI (AB) * 100
Experimental result is as shown in the table:
Table 1 Prochloraz thifluzamide is to the experimental data of Rhizoctonia solani Kuhn
| Reagent agent | EC50(m | Co-toxicity coefficient |
| g/l) | CTC | |
| Prochloraz | 0.65 | -- |
| Thifluzamide | 1.25 | -- |
| Prochloraz: thifluzamide (10:1) | 0.25 | 209.3 |
| Prochloraz: thifluzamide (5:1) | 0.17 | 233.2 |
| Prochloraz: thifluzamide (2:1) | 0.16 | 236.2 |
| Prochloraz: thifluzamide (1:1) | 0.11 | 356.9 |
| Prochloraz: thifluzamide (1:2) | 0.20 | 270.1 |
| Prochloraz: thifluzamide (1:5) | 0.24 | 205.4 |
| Prochloraz: thifluzamide (1:10) | 0.39 | 174.8 |
Experimental result shows:
Prochloraz and thifluzamide composite, to Rhizoctonia solani Kuhn, there is good indoor virulence, the CTC value of seven proportionings is all considerably beyond 120, show that these two bactericide have good synergistic function under this proportioning, also can find out that optimum proportioning is 1:1 in the composition along with its synergistic effect of difference of Prochloraz and thifluzamide ratio is also different simultaneously.
Embodiment
In order to understand technical scheme of the present invention better, be described in detail below by instantiation, but the present invention is not limited thereto.
Embodiment 1
16% Prochloraz thifluzamide aqueous emulsion preparation, each component proportion by weight:
Its preparation process is as follows: by Prochloraz and thifluzamide xylene soluble, add phenethyl phenol polyethenoxy ether, alkylphenol polyoxyethylene, organic silicone oil stir as oil phase, xanthans, urea being added to the water stirs as aqueous phase, under 1000-2000r/min stirs, aqueous phase is slowly added oil phase, then under 4000-5000r/min, high-speed circulating shears 30min, obtains product.
Embodiment 2
30% Prochloraz thifluzamide aqueous emulsion preparation, each component proportion by weight:
Preparation method is the same.
Embodiment 3
25% Prochloraz thifluzamide aqueous emulsion preparation, each component proportion by weight:
Preparation method is the same.
Experimental example
The several aqueous emulsions embodiment of the present invention obtained carry out field control effectiveness test, and contrast with other several bactericide, and result is as shown in the table:
The table 2 water prevention rice sheath blight field efficacy experimental result table of comparisons
As seen from the above table, under dilution 1000,1500 times of concentration, after aqueous emulsion medicine of embodiment of the present invention gained, after 7d and secondary medicine, the control efficiency of 7d is all higher than the single dose of the Prochloraz under same content and thifluzamide, and synergistic effect is obvious.
Comprehensive above result of the test shows, microbicide compositions aqueous emulsion of the present invention has good control efficiency to Rhizoctonia solani Kuhn, and uses safety, is the new formulation of environment-friendly high-efficiency.
Claims (10)
1. a composition aqueous emulsion for the water prevention rice sheath blight, is characterized in that, comprises Prochloraz and thifluzamide, and weight ratio is Prochloraz: thifluzamide=1-10:1-10.
2. composition aqueous emulsion according to claim 1, is characterized in that, described Prochloraz and thifluzamide weight ratio are 1:1.
3. composition aqueous emulsion according to claim 1, is characterized in that, comprises following component by weight: Prochloraz 1-10%, thifluzamide 1-10%, emulsifier 5-15%, cosolvent 5-20%, antifreezing agent 3-7%, defoamer 0.5-3%, thickener 0-2.5%, surplus is water.
4. composition aqueous emulsion according to claim 1, is characterized in that, described cosolvent is one or both in toluene, dimethylbenzene, solvent naphtha, cyclohexanone, dimethyl formamide, ethyl acetate, acetone or vegetable oil.
5. composition aqueous emulsion according to claim 1, is characterized in that, described emulsifier is nonionic surface active agent or anionic surfactant.
6. aqueous emulsion according to claim 5, it is characterized in that, described non-ionic surface active agent is one or more in phenethyl phenol polyethenoxy ether, phenethyl phenol polyethenoxy polyethenoxy ether, alkylphenol polyoxyethylene, alkylphenol polyoxyethylene formaldehyde condensation products, fatty alcohol-polyoxyethylene ether, castor oil polyoxyethylene ether, polystyrene-based phenol formaldehyde resin APEO, phenethyl phenol polyethenoxy ether phosphate or alkylphenol polyoxyethylene phosphate; Described anion surfactant is one or more in alkyl benzene calcium sulfonate, sodium alkyl benzene sulfonate or C8-C20 sodium alkyl sulfate.
7. composition aqueous emulsion according to claim 1, is characterized in that, described antifreezing agent is one or more in ethylene glycol, propane diols, glycerine, polyethylene glycol, sorbierite or urea.
8. composition aqueous emulsion according to claim 1, is characterized in that, described defoamer is organic silicone oil or isooctanol.
9. composition aqueous emulsion according to claim 1, is characterized in that, described thickener is one or more in xanthans, gum Arabic, carboxymethyl cellulose, CMC or polyvinyl alcohol.
10. one kind as arbitrary in claim 1 to 9 as described in the preparation method of aqueous emulsion, its step is as follows: Prochloraz and thifluzamide cosolvent are dissolved, add emulsifier, antifreezing agent, defoamer stir as oil phase, being added to the water by thickener stirs as aqueous phase, under 1000-2000r/min stirs oil phase added aqueous phase or aqueous phase adds oil phase, then under 4000-5000r/min, high-speed circulating shears 30 ~ 50min, obtains aqueous emulsion product.
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| CN201410681360.2A CN104430466A (en) | 2014-11-24 | 2014-11-24 | Water emulsion composition for preventing and treating rice sheath blight and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105309461A (en) * | 2015-10-26 | 2016-02-10 | 广西南宁益土生物科技有限责任公司 | Bactericide containing prochloraz and cinnamaldehyde |
| CN106857624A (en) * | 2017-03-29 | 2017-06-20 | 兴农药业（中国）有限公司 | A kind of compound pesticide composition containing thifluzamide and Prochloraz |
-
2014
- 2014-11-24 CN CN201410681360.2A patent/CN104430466A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105309461A (en) * | 2015-10-26 | 2016-02-10 | 广西南宁益土生物科技有限责任公司 | Bactericide containing prochloraz and cinnamaldehyde |
| CN106857624A (en) * | 2017-03-29 | 2017-06-20 | 兴农药业（中国）有限公司 | A kind of compound pesticide composition containing thifluzamide and Prochloraz |
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