CN104415126A - Rhodiola rosea burn spray - Google Patents

Abstract

The invention relates to a rhodiola rosea burn spray. According to the rhodiola rosea burn spray, rhodiola rosea, acacia catechu, liquorice, rhizoma coptidis, radix angelicae, safflower, garden burnet, borneol, glycerol and ethyl alcohol and the like are used as the main raw materials, are differently preprocessed according to different characteristics of the traditional Chinese medicines and are prepared into an ointment forming agent according to a ratio. The rhodiola rosea burn spray has good waterproof, bacteria-proof, anti-inflammatory, antioncotic, breathable and astringent functions, and is suitable for treating symptoms such as skin burn caused by various reasons. The rhodiola rosea burn spray belongs to the field of clinic treatment of burn. The technical principle adopted by the invention is as follows: by utilizing synergistic effect of a plurality of traditional Chinese herbs, the rhodiola rosea burn spray can be used for effectively isolating wound surface and is capable of quickly permeating into the tissue and protecting exposed and damaged nerve endings from being excited by the algogenic substance; the residual waste heat in the tissue can be quickly absorbed; the microcirculation of the stagnation can be improved; the continuous burn tissue necrosis is blocked; the tissue damage is alleviated; the inflection is prevented and controlled in all directions; the newborn skin coverage of burn, scald and ambustion can be accelerated; the scar is avoided; the healing time is shortened.

Description

Radix Rhodiolae SHAOSHANG PENWUJI

technical fieldthe present invention relates to a kind of Radix Rhodiolae SHAOSHANG PENWUJI, it mainly with Radix Rhodiolae, catechu, Radix Glycyrrhizae, Rhizoma Coptidis, the Radix Angelicae Dahuricae, Flos Carthami, Radix Sanguisorbae, Borneolum Syntheticum, glycerol, ethanol etc. for raw material, according to the different qualities of every taste Chinese medicine, after different pretreatments, be configured to unguentum in proportion, there is good waterproof every effect of bacterium, anti-inflammation detumescence, ventilative convergence, be applicable to treat the symptoms such as the skin burn that a variety of causes causes.The technology of the present invention belongs to Burns treatment field.Know-why of the present invention adopts multiple Chinese herbal medicine synergism, and effectively can isolate wound surface and infiltrate very soon in tissue, protection has exposed the stimulation of teleneuron from algogenic substance of damage; Remain waste heat in rapid absorptive tissue, improve the stagnant microcirculation of what simultaneously, block tissue of burn necrosis progrediens, alleviate tissue injury; Prevention and corntrol infects in all directions, accelerates the only skin covering of burning, scalding, burning, without cicatrix, shortens healing time.

background technologyburn is also known as scald, and body directly contacts high temp objects or is subject to the change that strong heat radiation occurs.The degree of burn is by the height of temperature, the length of action time and different.The change of local can be divided into four degree.First degree: congested because of angioparalysis.Second degree: form the burn vesicle being full of serum.3rd degree: tissue necrosis.Fourth: the carbonization of tissue.Scar hyperplasia is serious sequela after burn patient wound healing, caused by the pathological change in the agglutination of wound surface own.According to statistics, in the wounded of scar hyperplasia, the age accounted for 70-80% below 30 years old; The people of coloured race and cicatrix body constitution, has the tendency that cicatrix hyperplasia occurs; Chemical burn, napalm burn, the serious cicatrix of normal generation; Burn darker (dark more than two degree wound surface), scar hyperplasia is more obvious; Traumatic infection often can increase chance and the order of severity of cicatrization; Scar contracture and hypertrophy can have a strong impact on the quality of life of patient.

Owing to it be unclear that the mechanism of cicatrization, therefore also do not prevent and treat the specific medicament of cicatrix at present, but early prevention there is certain effect to scar hyperplasia and contracture.Preventive measure mainly contains: deep wounds should prevent and infection control, as long as systemic conditions allows, carries out surgery skin grafting as early as possible; Wound surface, once healing, namely adheres to, with Elastic bandage or elastic sleeve pressurization, adhering to round the clock, can effectively reduce scar contracture and hypertrophy like this during use as early as possible; Carry out the dysfunction that functional exercise causes to alleviate scar contracture as early as possible.Namely many opinions carry out early functional exercise in burn treating process at present, if patient actively coordinates, often can obtain comparatively ideal therapeutic effect.

Radix Rhodiolae is the dry root welding technology of crassulaceae plants Radix Rhodiolae, and property is flat, puckery, has improving water flood, detumescence is become silted up in blood-enriching and blood-promoting circulation, anti-cerebral anoxia, resisting fatigue, promoting blood circulation and hemostasis, clearing away lung-heat to relieve cough, change, antipyreticly to bring down a fever, nourish the effects such as vigour; Be used for the treatment of traumatic injury and burn and scald outward.The present invention adopts Radix Rhodiolae as treatment burn Main Function composition, and effectively can isolate wound surface and infiltrate very soon in tissue, protection has exposed the stimulation of teleneuron from algogenic substance of damage; Remain waste heat in rapid absorptive tissue, improve the stagnant microcirculation of what simultaneously, block tissue of burn necrosis progrediens, alleviate tissue injury; Prevention and corntrol infects in all directions, accelerates the only skin covering of burning, scalding, burning, without cicatrix, shortens healing time.

summary of the inventionmain points of the present invention are to adopt Radix Rhodiolae, catechu, Radix Glycyrrhizae, Rhizoma Coptidis, the Radix Angelicae Dahuricae, Flos Carthami, Radix Sanguisorbae, Borneolum Syntheticum, glycerol, ethanol are that main component is used modern technologies to be carefully dished up to form; outer for after burn wound; form layer protecting film immediately; there is effect of antibacterial bacteriostatic, putrefaction-removing granulation-promoting; the downright bad crust of burn or eschar can be made to liquefy rapidly disengaging, avoid the generation of burn wound sepsis.

The formula that the present invention selects following (component and percentage by weight % thereof): Radix Rhodiolae 3.0-6.0, catechu 3.0-6.0, Radix Glycyrrhizae 2.0-4.0, Rhizoma Coptidis 1.0-3.0, Radix Angelicae Dahuricae 1.0-3.0, Flos Carthami 0.1-1.0, Radix Sanguisorbae 0.1-1.0, Borneolum Syntheticum 0.1-1.0, glycerol 3.0-6.0, ethanol 60.0-70.0, water adds to 100.

The dry root welding technology of Radix Rhodiolae crassulaceae plants Radix Rhodiolae, its applicating history is long, and before more than 2,000 year, the people of Qinghai-Tibet Platean is just used as medicine with it, with building body, the impact of opposing poor environment.Among the people being commonly used to is decocted water or steeps in wine, to banish fatigue or to resist mountain area cold.Simultaneously and diseases prevention is healthy and strong and nourishing lengthens one's life.Because it has magical effect of strengthening healthy qi, benefiting qi and nourishing blood, YIN nourishing lung benefiting, successive dynasties Tibetan medicine is regarded as " lucky three essentials-essence ".Nineteen sixties, Soviet scientists found, it has adaptive significances, and health can be assisted to reply stable state.That is Radix Rhodiolae can improve the various stimulation from chemistry, biology or physical factor of body-defence.About the research of Radix Rhodiolae, except traditional resistance to compression function, scientist is also absorbed in some new discoveries, comprises anticancer and anti-diabetic etc.Be used for the treatment of traumatic injury and burn and scald outward.

Catechu odorless, puckery, bitter first ,sweet later.Containing catechutannic acid 20 ~ 50%, cachou extract 2 ~ 20% and epicatechol, phlegmatic temperament, fatty oil, natural gum and wax etc.Catechu decoct all has inhibitory action to staphylococcus aureus, diphtheria corynebacterium, Bacillus proteus, shigella flexneri and Bacillus typhi; Also inhibitory action is had for common therapeutic dermatophytes.The extract of its leaf all has inhibitory action to staphylococcus aureus, escherichia coli.Catechu has the effect of removing dampness promoting tissue regeneration and ulcer healing, and for ulcer being unable to heal, eczema, aphtha, falls and flutter the pain of injury, traumatic hemorrhage.

Radix Glycyrrhizae property is put down, and sweet in the mouth, returns 12 warps.There is removing toxic substances, eliminate the phlegm, pain relieving, spasmolytic is so that the pharmacological action such as anticancer.In the traditional Chinese medical science, Radix Glycyrrhizae invigorating the spleen and replenishing QI, relieving cough and moistening lung, emergency is detoxified, and is in harmonious proportion hundred medicines.Clinical practice divides, and " life is used " is not with " processed with honey ".Raw with curing mainly laryngopharynx swelling and pain, cellulitis skin infection, gastrointestinal ulceration and solution poison of drug, alimentary toxicosis etc.; Processed with honey cures mainly spleen and stomach function and goes down, and large loose stool is thin, weak heating and cough, cardiopalmus etc.Radix Glycyrrhizae is used for insufficiency of heart-QI, severe palpitation, irregularly intermittent and regularly intermittent pulse, and deficiency of spleen-QI and stomach-QI, fatigue and weakness etc.The former, normal and Ramulus Cinnamomi compatibility, as Ramuli Cinnamomi and Glycyrrhizae Decoction, zhigancao decoction.The latter, is often equal to use with Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, as ball in decoction of four noble drugs, reason etc.For asthma and cough.Can be alone, also can the application of compatibility other drug.As controlled the ERCHEN TANG of cough due to damp-phlegm; Control the Linggan Wuwei Jiangxin Tang of cold-phlegm cough with asthma; Control the sangxing decoction of dry stool phlegm cough; Control pyretic toxicity and cause lung abscess cough and spit and to smell as of rotten fish the Radix Platycodonis decoction of purulent sputum; Control the Gancao Ganjiang soup etc. of cough and spit saliva foam.The also Chang Peiwu application of another cough due to pathogenic wind-heat, cough due to wind and cold, phlegm heat cough.For ulcer sores, laryngopharynx swelling and pain etc.Can be alone, for oral administration or external application, or compatibility application.Ulcer sores, is often equal to use with Flos Lonicerae, Fructus Forsythiae, plays the merit of heat-clearing and toxic substances removing altogether, as Xian fang Huoming Yin.Laryngopharynx swelling and pain, the normal and same use of Radix Platycodonis, as Radix Platycodonis decoction.

Rhizoma Coptidis another name Wang Lian, Zhi Lian.Nature and flavor are bitter, cold, nontoxic.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.There is heat clearing and damp drying, effect of eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, and toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.It is burning hot that Rhizoma Coptidis (processed with wine) is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.For conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.Tie mutually for cold and heat, damp and hot middle resistance, feeling of fullness is vomitted.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomiting acid regurgitation.

The Radix Angelicae Dahuricae is warm in nature, and acrid in the mouth is micro-sweet, expelling wind and cold, understand things pain-stopping, evacuation of pus of invigorating blood circulation, granulation promoting pain relieving, dampness leukorrhagia stopping, for mastalgia, swell and ache, have a headache, have a toothache, nasal sinusitis, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus.Water decoction to escherichia coli, adopt Shigella flexneri, Bacillus typhi, Salmonella paratyphi, bacillus pyocyaneus, Bacillus proteus, vibrio cholera, human body tubercule bacillus etc. and have inhibitory action.Infusion also has certain inhibitory action to pathomycetes such as Microsporon audouinis.Modern pharmacological research proves that the Radix Angelicae Dahuricae also has antiinflammatory, antipyretic-antalgic, active eliminating stagnation, can be used for controlling the effects such as mammary gland caking with other Chinese Medicine and Clavicular.Radix Angelicae Dahuricae external is beauty treatment key medicine.The Compendium of Material Medica meaning Radix Angelicae Dahuricae " longue skin, moist color, can make face fat ", in ancient times beauty treatment sides multiplex it.

Flos Carthami is warm in nature, acrid in the mouth, promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, traumatic injury, be suitable for various varicosis, peripheral neuritis, blood circulation is bad, lower limb numbness or the congestion such as livid purple.Containing higher linoleic acid in Semen Carthami oil, have and reduce blood fat and serum cholesterol, softening and expansion artery, atherosclerosis, increase blood circulation, regulate the effect of heart and aged hormonal system.Semen Carthami oil is also good industry and medicinal oil.Also can paint, the spraying paint and coating of accurate parts, be also the raw material manufacturing alkyd resins.Pharmaceutically be used as the stabilizing agent of antioxidant and vitamin A and D.Grouts after oil expression, containing rich in protein, can do concentrated feed pasture.

Radix Sanguisorbae contains tannin, has astriction, can antidiarrheal and hemostasis.External Radix Sanguisorbae preparata powder, has remarkable astriction to II degree, the III degree experimental scald face of rabbit and Canis familiaris L., can make to ooze out minimizing, infect and mortality rate reduction.But the tannin extracted from Radix Sanguisorbae or commercially available tannic acid, to the curative effect of burning all not as Radix Sangusorbae powder.The effective ingredient of prompting Radix Sanguisorbae treatment burn, except contained tannin, still has other factors to participate in.The curative effect ratio of Radix Sanguisorbae to the structural burn of denervation does not have the structural curative effect of denervation slightly poor.Experiment in vitro proves: the decocting liquid of Radix Sanguisorbae 100% is to Bacillus typhi, meningococcus, shigella flexneri, bacterium sonnei, beta hemolytic streptococcus, staphylococcus aureus, Diplococcus pneumoniae, diphtheria corynebacterium, escherichia coli, bacillus subtilis, Bacillus typhi, Salmonella paratyphi, bacillus pyocyaneus, vibrio cholera and Bacillus tuberculosis all have inhibitory action in various degree. also there is inhibitory action in various degree to some fungus. and decoct is effective to Asia influenza A virus when 0.5mg/ml. and there is report to think, the antibacterial action of Radix Sanguisorbae is with wherein contained tannic acid is relevant.

Borneolum Syntheticum, has another name called sheet brain, Fructus Citri tangerinae sheet, Borneolum Syntheticum, MEIHUA BINGPIAN, Dipterocarpus pilosus, Flos Mume brain, Borneolum Syntheticum brain, Mei Bing etc., and being that resin and the volatile oil processed goods of Spore density Borneolum Syntheticum extracts the crystallization obtained, is near pure dextro Borneolum Syntheticum.Also have and chemically synthesize.Borneolum Syntheticum acrid in the mouth, hardship, be slightly cold; GUIXIN, liver, lung meridian; A surname is loose for delicate fragrance, has refreshment of having one's ideas straightened out, the loose poison of heat clearing away, effect of improving acuity of vision and removing nebula, and it can be used for for excess syndrome of stroke coma, for conjunctival congestion and swelling pain, sore throat aphtha, swells and ache for skin infection, does not hold back after bursting.

The preparation method of product of the present invention is:

(1) Radix Rhodiolae, catechu, Radix Glycyrrhizae, Rhizoma Coptidis, the Radix Angelicae Dahuricae, Flos Carthami, Radix Sanguisorbae are mixed in proportion, and put into 90% ethanol and soak one month;

(2) appropriate Borneolum Syntheticum is weighed, and with 90% dissolve with ethanol Borneolum Syntheticum;

(3) Borneolum Syntheticum after dissolving is converted into the liquid, and mix homogeneously;

(4) glycerol is added in proportion, mix homogeneously;

(5) add suitable quantity of water, regulate concentration of alcohol in medicinal liquid to be 60-70%;

(6) sample immediately, after the assay was approved, subpackage, labeling, sealing.

The present invention has the following advantages:

(1) not containing any hormone, adopt natural crude drugs, have no side effect;

(2) effectively can isolate wound surface and infiltrate very soon in tissue, protection has exposed the stimulation of teleneuron from algogenic substance of damage;

(3) remain waste heat in rapid absorptive tissue, improve the stagnant microcirculation of what simultaneously, block tissue of burn necrosis progrediens, alleviate tissue injury;

(4) accelerate the only skin covering of burning, scalding, burning, without cicatrix, shorten healing time;

(5) few, the good stability of use amount, technique is simple;

(6) there is good compliance, be applicable to the symptoms such as treatment burn.

detailed description of the inventionbelow in conjunction with embodiment, the present invention is described in further detail:

Be configured according to data listed in Table (percentage by weight %) and described step thereof:

Formula one:

Radix Rhodiolae 3.0-4.0, catechu 3.0-4.0, Radix Glycyrrhizae 2.0-3.0, Rhizoma Coptidis 1.0-2.0, Radix Angelicae Dahuricae 2.0-3.0, Flos Carthami 0.1-1.0, Radix Sanguisorbae 0.1-1.0, Borneolum Syntheticum 0.1-1.0, glycerol 5.0-6.0, ethanol 65.0-70.0, water adds to 100.

Formula two:

Radix Rhodiolae 5.0-6.0, catechu 5.0-6.0, Radix Glycyrrhizae 2.0-3.0, Rhizoma Coptidis 1.0-2.0, Radix Angelicae Dahuricae 1.0-2.0, Flos Carthami 0.1-1.0, Radix Sanguisorbae 0.1-1.0, Borneolum Syntheticum 0.1-1.0, glycerol 5.0-6.0, ethanol 68.0-70.0, water adds to 100.

Formula three:

Radix Rhodiolae 3.0-5.0, catechu 5.0-6.0, Radix Glycyrrhizae 3.0-4.0, Rhizoma Coptidis 2.0-3.0, Radix Angelicae Dahuricae 1.0-2.0, Flos Carthami 0.1-1.0, Radix Sanguisorbae 0.1-1.0, Borneolum Syntheticum 0.1-1.0, glycerol 3.0-4.0, ethanol 60.0-65.0, water adds to 100.

Claims (2)

1. the present invention relates to a kind of Radix Rhodiolae SHAOSHANG PENWUJI, it is characterized in that there is following formula (component and percentage by weight % thereof): Radix Rhodiolae 3.0-6.0, catechu 3.0-6.0, Radix Glycyrrhizae 2.0-4.0, Rhizoma Coptidis 1.0-3.0, Radix Angelicae Dahuricae 1.0-3.0, Flos Carthami 0.1-1.0, Radix Sanguisorbae 0.1-1.0, Borneolum Syntheticum 0.1-1.0, glycerol 3.0-6.0, ethanol 60.0-70.0, water adds to 100.

2. a kind of Radix Rhodiolae SHAOSHANG PENWUJI according to claim 1, is characterized in that having following preparation technology:

(1) Radix Rhodiolae, catechu, Radix Glycyrrhizae, Rhizoma Coptidis, the Radix Angelicae Dahuricae, Flos Carthami, Radix Sanguisorbae are mixed in proportion, and put into 90% ethanol and soak one month;

(2) appropriate Borneolum Syntheticum is weighed, and with 90% dissolve with ethanol Borneolum Syntheticum;

(3) Borneolum Syntheticum after dissolving is converted into the liquid, and mix homogeneously;

(4) glycerol is added in proportion, mix homogeneously;

(5) add suitable quantity of water, regulate concentration of alcohol in medicinal liquid to be 60-70%;

(6) sample immediately, after the assay was approved, subpackage, labeling, sealing.