CN104399112A - 含有大蒜挥发油的亲水性压敏胶及其制备方法 - Google Patents

含有大蒜挥发油的亲水性压敏胶及其制备方法 Download PDF

Info

Publication number
CN104399112A
CN104399112A CN201410626937.XA CN201410626937A CN104399112A CN 104399112 A CN104399112 A CN 104399112A CN 201410626937 A CN201410626937 A CN 201410626937A CN 104399112 A CN104399112 A CN 104399112A
Authority
CN
China
Prior art keywords
volatile oil
polyurethane
sensitive adhesive
pressure
bulbus allii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201410626937.XA
Other languages
English (en)
Other versions
CN104399112B (zh
Inventor
邱东成
刘乐峰
郭玉芹
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pizhou Qiwei Food Technology Co Ltd
Original Assignee
SUZHOU VIVOTIDE BIOTECHNOLOGIES CO Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SUZHOU VIVOTIDE BIOTECHNOLOGIES CO Ltd filed Critical SUZHOU VIVOTIDE BIOTECHNOLOGIES CO Ltd
Priority to CN201610540396.8A priority Critical patent/CN106177373A/zh
Priority to CN201610540403.4A priority patent/CN106177374A/zh
Priority to CN201610540395.3A priority patent/CN106177372A/zh
Priority to CN201410626937.XA priority patent/CN104399112B/zh
Priority to CN201610540570.9A priority patent/CN106075548A/zh
Priority to CN201610540404.9A priority patent/CN106075547A/zh
Publication of CN104399112A publication Critical patent/CN104399112A/zh
Application granted granted Critical
Publication of CN104399112B publication Critical patent/CN104399112B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0019—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0066—Medicaments; Biocides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/48—Polyethers
    • C08G18/4854—Polyethers containing oxyalkylene groups having four carbon atoms in the alkylene group
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/65—Low-molecular-weight compounds having active hydrogen with high-molecular-weight compounds having active hydrogen
    • C08G18/66—Compounds of groups C08G18/42, C08G18/48, or C08G18/52
    • C08G18/6666—Compounds of group C08G18/48 or C08G18/52
    • C08G18/667—Compounds of group C08G18/48 or C08G18/52 with compounds of group C08G18/32 or polyamines of C08G18/38
    • C08G18/6681—Compounds of group C08G18/48 or C08G18/52 with compounds of group C08G18/32 or polyamines of C08G18/38 with compounds of group C08G18/32 or C08G18/3271 and/or polyamines of C08G18/38
    • C08G18/6685—Compounds of group C08G18/48 or C08G18/52 with compounds of group C08G18/32 or polyamines of C08G18/38 with compounds of group C08G18/32 or C08G18/3271 and/or polyamines of C08G18/38 with compounds of group C08G18/3225 or polyamines of C08G18/38
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
    • C08G18/72—Polyisocyanates or polyisothiocyanates
    • C08G18/74—Polyisocyanates or polyisothiocyanates cyclic
    • C08G18/75—Polyisocyanates or polyisothiocyanates cyclic cycloaliphatic
    • C08G18/751—Polyisocyanates or polyisothiocyanates cyclic cycloaliphatic containing only one cycloaliphatic ring
    • C08G18/752—Polyisocyanates or polyisothiocyanates cyclic cycloaliphatic containing only one cycloaliphatic ring containing at least one isocyanate or isothiocyanate group linked to the cycloaliphatic ring by means of an aliphatic group
    • C08G18/753—Polyisocyanates or polyisothiocyanates cyclic cycloaliphatic containing only one cycloaliphatic ring containing at least one isocyanate or isothiocyanate group linked to the cycloaliphatic ring by means of an aliphatic group containing one isocyanate or isothiocyanate group linked to the cycloaliphatic ring by means of an aliphatic group having a primary carbon atom next to the isocyanate or isothiocyanate group
    • C08G18/755—Polyisocyanates or polyisothiocyanates cyclic cycloaliphatic containing only one cycloaliphatic ring containing at least one isocyanate or isothiocyanate group linked to the cycloaliphatic ring by means of an aliphatic group containing one isocyanate or isothiocyanate group linked to the cycloaliphatic ring by means of an aliphatic group having a primary carbon atom next to the isocyanate or isothiocyanate group and at least one isocyanate or isothiocyanate group linked to a secondary carbon atom of the cycloaliphatic ring, e.g. isophorone diisocyanate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Materials Engineering (AREA)
  • Surgery (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)

Abstract

本发明提供一种含有大蒜挥发油的亲水性压敏胶及其制备方法，该压敏胶按重量份计，包括如下组分：聚氨酯30~40份，海藻酸盐40~55份，壳聚糖10~25份，大蒜挥发油0.1~10份及柠檬酸三丁酯2~5份；所述聚氨酯由聚四氢呋喃二醇与异佛尔酮二异氰酸酯缩合得到。制备方法：包括如下步骤：（1）聚氨酯的制备；（2）含有大蒜挥发油的亲水性聚氨酯压敏胶的制备。该含有大蒜挥发油的亲水性聚氨酯压敏胶具有抗感染、促进伤口愈合等疗效，对人体无毒、无刺激性、无过敏性、无剥落反应，是安全可靠的医用压敏胶，具有明显的经济效益。

Description

含有大蒜挥发油的亲水性压敏胶及其制备方法
技术领域        
本发明涉及生物医用压敏胶领域，具体涉及一种含有大蒜挥发油的亲水性压敏胶及其制备方法。
背景技术
随着医学的进步，临床上对手术技术和辅助材料效果的要求越来越高。现代医学的理念是要最大限度地减少病人的痛苦。最快速度地让病人康复，而且在最大程度的恢复功能的同时，希望外观也能完美地恢复。因此，临床需求的不断增加推动了粘合剂的发展和粘合技术在临床的应用。
压敏胶是一类在压力下产生粘性，在失压后不留残余物的粘合剂，是透皮吸收制剂的主要辅料。
大蒜，是百合科葱属植物，提取得到的大蒜挥发油具有抑菌抗炎、解毒消肿等功能。但目前尚未有报道指出将大蒜挥发油用于制备压敏胶。
发明内容
基于上述信息，本发明的目的在于提供一种含有大蒜挥发油的亲水性压敏胶，该压敏胶贴于患者患处时，大蒜挥发油缓释挥发抗菌作用，达到治疗的目的，该压敏胶具有无刺激和毒副作用，生物相容性好。
本发明的技术方案如下：
一种聚甲基丙烯酸酯/羟基磷灰石复合生物陶瓷材料的制备方法，包括如下步骤：
一种含有大蒜挥发油的亲水性聚氨酯压敏胶，按重量份计，包括如下组分：聚氨酯30~40份，海藻酸盐40~55份，壳聚糖10~25份，大蒜挥发油0.1~10份及柠檬酸三丁酯2~5份；所述聚氨酯由聚四氢呋喃二醇与异佛尔酮二异氰酸酯缩合得到。
所述聚氨酯是不同分子量的混合体，其中分子量1000~3000的占聚氨酯总重量的10~25%，分子量30000~80000的占聚氨酯总重量35~50%，分子量100000~150000的占聚氨酯总重量的25%~40%。
所述海藻酸盐为海藻酸钠。
所述壳聚糖的脱乙酰度≥92%。
所述大蒜挥发油的制备方法为：所述大蒜挥发油的制备方法为：将大蒜去皮，洗净，捣碎，加入2~6倍量的水，在60~120℃下发酵2小时，水蒸气蒸馏0.5小时，分离油层，即得大蒜挥发油。
一种含有大蒜挥发油的亲水性聚氨酯压敏胶的制备方法，包括如下步骤：
（1）聚氨酯的制备
将聚四氢呋喃二醇加入反应器中，在100~120℃下熔融减压除水，在65~70℃和常压下，按异氰酸酯基/醇羟基摩尔比为115：210的投料比加入异佛尔酮二异氰酸酯，并加入丁酮作为溶剂，在80~85℃下反应1.5~2 h，然后向体系中加入用丁酮溶解的胺类扩链剂，反应2h，经减压除去丁酮溶剂，出料，得到聚氨酯粗品，备用；
（2）含有大蒜挥发油的亲水性聚氨酯压敏胶的制备
将步骤（1）制备的聚氨酯粗品与海藻酸盐在开炼机中混炼30~40分钟，再将壳聚糖、大蒜挥发油和柠檬酸三丁酯添加进去继续混炼10~20分钟，使其均匀分散，然后用平板硫化机在硫化温度为40~48℃，硫化时间为2~4s，硫化压强为6~7MPa的条件下热压成所需厚度的压敏胶。
本发明的有益效果为：该含有大蒜挥发油的亲水性聚氨酯压敏胶具有抗感染、促进伤口愈合等疗效，对人体无毒、无刺激性、无过敏性、无剥落反应，是安全可靠的医用压敏胶，具有明显的经济效益。
具体实施方式
以下对本发明的具体实施方式进行详细说明。
实施例1
（1）聚氨酯的制备
将聚四氢呋喃二醇加入反应器中，在100℃下熔融减压除水，在65℃和常压下，按异氰酸酯基/醇羟基摩尔比为115：210的投料比加入异佛尔酮二异氰酸酯，并加入丁酮作为溶剂，在80℃下反应1.5h，然后向体系中加入用丁酮溶解的胺类扩链剂，反应2h，经减压除去丁酮溶剂，出料，得到聚氨酯粗品，备用；
（2）含有大蒜挥发油的亲水性聚氨酯压敏胶的制备
将步骤（1）制备的聚氨酯粗品30份与海藻酸盐40份在开炼机中混炼30分钟，再将壳聚糖10份、大蒜挥发油0.1份和柠檬酸三丁酯2份添加进去继续混炼10分钟，使其均匀分散，然后用平板硫化机在硫化温度为40℃，硫化时间为2s，硫化压强为6MPa的条件下热压成所需厚度的压敏胶。
实施例2
（1）聚氨酯的制备
将聚四氢呋喃二醇加入反应器中，在105℃下熔融减压除水，在66℃和常压下，按异氰酸酯基/醇羟基摩尔比为115：210的投料比加入异佛尔酮二异氰酸酯，并加入丁酮作为溶剂，在82℃下反应1.6 h，然后向体系中加入用丁酮溶解的胺类扩链剂，反应2h，经减压除去丁酮溶剂，出料，得到聚氨酯粗品，备用；
（2）含有大蒜挥发油的亲水性聚氨酯压敏胶的制备
将步骤（1）制备的聚氨酯粗品32份与海藻酸盐45份在开炼机中混炼32分钟，再将壳聚糖15份、大蒜挥发油1份和柠檬酸三丁酯3份添加进去继续混炼13分钟，使其均匀分散，然后用平板硫化机在硫化温度为42℃，硫化时间为3s，硫化压强为6MPa的条件下热压成所需厚度的压敏胶。
实施例3
（1）聚氨酯的制备
将聚四氢呋喃二醇加入反应器中，在110℃下熔融减压除水，在68℃和常压下，按异氰酸酯基/醇羟基摩尔比为115：210的投料比加入异佛尔酮二异氰酸酯，并加入丁酮作为溶剂，在84℃下反应1.8 h，然后向体系中加入用丁酮溶解的胺类扩链剂，反应2h，经减压除去丁酮溶剂，出料，得到聚氨酯粗品，备用；
（2）含有大蒜挥发油的亲水性聚氨酯压敏胶的制备
将步骤（1）制备的聚氨酯粗品36份与海藻酸盐50份在开炼机中混炼35分钟，再将壳聚糖20份、大蒜挥发油5份和柠檬酸三丁酯4份添加进去继续混炼16分钟，使其均匀分散，然后用平板硫化机在硫化温度为45℃，硫化时间为4s，硫化压强为7MPa的条件下热压成所需厚度的压敏胶。
实施例4
（1）聚氨酯的制备
将聚四氢呋喃二醇加入反应器中，在120℃下熔融减压除水，在70℃和常压下，按异氰酸酯基/醇羟基摩尔比为115：210的投料比加入异佛尔酮二异氰酸酯，并加入丁酮作为溶剂，在85℃下反应2 h，然后向体系中加入用丁酮溶解的胺类扩链剂，反应2h，经减压除去丁酮溶剂，出料，得到聚氨酯粗品，备用；
（2）含有大蒜挥发油的亲水性聚氨酯压敏胶的制备
将步骤（1）制备的聚氨酯粗品40份与海藻酸盐55份在开炼机中混炼40分钟，再将壳聚糖25份、大蒜挥发油10份和柠檬酸三丁酯5份添加进去继续混炼20分钟，使其均匀分散，然后用平板硫化机在硫化温度为48℃，硫化时间为4s，硫化压强为7MPa的条件下热压成所需厚度的压敏胶。
病例：
对20例皮肤溃烂患者采用含有大蒜挥发油的亲水性聚氨酯压敏胶贴于患处，取得良好效果。对象：男14例，女6例，年龄42~76（平均59）岁。皮肤溃烂出现的时间2天~2个星期，平均形成时间8天，均发生在腿部。治疗方法：用典伏棉球进行溃烂面周围皮肤消毒，盐水反复冲洗后，将压敏胶贴于患处，每天换药1 次。疗效标准：1周左右溃烂面完全恢复正常，不留疤痕为痊愈； 1周左右溃烂面结痂、干燥为显效；连续用药2个星期溃烂面无改变为无效。结果：20 例中痊愈16例，显效3例，无效1例。
尽管本发明的实施方案已公开如上，但其并不仅仅限于说明书和实施方式中所列运用，它完全可以被适用于各种适合本发明的领域，对于熟悉本领域的人员而言，可容易地实现另外的修改，因此在不背离权利要求及等同范围所限定的一般概念下，本发明并不限于特定的细节。

Claims (6)

1.一种含有大蒜挥发油的亲水性聚氨酯压敏胶，其特征在于，按重量份计，包括如下组分：聚氨酯30~40份，海藻酸盐40~55份，壳聚糖10~25份，大蒜挥发油0.1~10份及柠檬酸三丁酯2~5份；所述聚氨酯由聚四氢呋喃二醇与异佛尔酮二异氰酸酯缩合得到。
2.根据权利要求1所述的含有大蒜挥发油的亲水性聚氨酯压敏胶，其特征在于，聚氨酯是不同分子量的混合体，其中分子量1000~3000的占聚氨酯总重量的10~25%，分子量30000~80000的占聚氨酯总重量35~50%，分子量100000~150000的占聚氨酯总重量的25%~40%。
3.根据权利要求1所述的含有大蒜挥发油的亲水性聚氨酯压敏胶，其特征在于，所述海藻酸盐为海藻酸钠。
4.根据权利要求1所述的含有大蒜挥发油的亲水性聚氨酯压敏胶，其特征在于，所述壳聚糖的脱乙酰度≥92%。
5.根据权利要求1所述的含有大蒜挥发油的亲水性聚氨酯压敏胶，其特征在于，所述大蒜挥发油的制备方法为：将大蒜去皮，洗净，捣碎，加入2~6倍量的水，在60~120℃下发酵2小时，水蒸气蒸馏0.5小时，分离油层，即得大蒜挥发油。
6.基于权利要求1所述的含有大蒜挥发油的亲水性聚氨酯压敏胶的制备方法，其特征在于，包括如下步骤：
（1）聚氨酯的制备
将聚四氢呋喃二醇加入反应器中，在100~120℃下熔融减压除水，在65~70℃和常压下，按异氰酸酯基/醇羟基摩尔比为115：210的投料比加入异佛尔酮二异氰酸酯，并加入丁酮作为溶剂，在80~85℃下反应1.5~2 h，然后向体系中加入用丁酮溶解的胺类扩链剂，反应2h，经减压除去丁酮溶剂，出料，得到聚氨酯粗品，备用；
（2）含有大蒜挥发油的亲水性聚氨酯压敏胶的制备
将步骤（1）制备的聚氨酯粗品与海藻酸盐在开炼机中混炼30~40分钟，再将壳聚糖、大蒜挥发油和柠檬酸三丁酯添加进去继续混炼10~20分钟，使其均匀分散，然后用平板硫化机在硫化温度为40~48℃，硫化时间为2~4s，硫化压强为6~7MPa的条件下热压成所需厚度的压敏胶。
CN201410626937.XA 2014-11-10 2014-11-10 含有大蒜挥发油的亲水性压敏胶及其制备方法 Active CN104399112B (zh)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CN201610540396.8A CN106177373A (zh) 2014-11-10 2014-11-10 一种含有大蒜挥发油的亲水性压敏胶
CN201610540403.4A CN106177374A (zh) 2014-11-10 2014-11-10 一种抗感染的含有大蒜挥发油的亲水性压敏胶
CN201610540395.3A CN106177372A (zh) 2014-11-10 2014-11-10 抗感染、促进伤口愈合的含有大蒜挥发油的亲水性压敏胶
CN201410626937.XA CN104399112B (zh) 2014-11-10 2014-11-10 含有大蒜挥发油的亲水性压敏胶及其制备方法
CN201610540570.9A CN106075548A (zh) 2014-11-10 2014-11-10 含有大蒜挥发油的亲水性压敏胶
CN201610540404.9A CN106075547A (zh) 2014-11-10 2014-11-10 抗感染的含有大蒜挥发油的亲水性压敏胶

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201410626937.XA CN104399112B (zh) 2014-11-10 2014-11-10 含有大蒜挥发油的亲水性压敏胶及其制备方法

Related Child Applications (5)

Application Number Title Priority Date Filing Date
CN201610540403.4A Division CN106177374A (zh) 2014-11-10 2014-11-10 一种抗感染的含有大蒜挥发油的亲水性压敏胶
CN201610540395.3A Division CN106177372A (zh) 2014-11-10 2014-11-10 抗感染、促进伤口愈合的含有大蒜挥发油的亲水性压敏胶
CN201610540570.9A Division CN106075548A (zh) 2014-11-10 2014-11-10 含有大蒜挥发油的亲水性压敏胶
CN201610540396.8A Division CN106177373A (zh) 2014-11-10 2014-11-10 一种含有大蒜挥发油的亲水性压敏胶
CN201610540404.9A Division CN106075547A (zh) 2014-11-10 2014-11-10 抗感染的含有大蒜挥发油的亲水性压敏胶

Publications (2)

Publication Number Publication Date
CN104399112A true CN104399112A (zh) 2015-03-11
CN104399112B CN104399112B (zh) 2016-09-28

Family

ID=52636817

Family Applications (6)

Application Number Title Priority Date Filing Date
CN201610540403.4A Withdrawn CN106177374A (zh) 2014-11-10 2014-11-10 一种抗感染的含有大蒜挥发油的亲水性压敏胶
CN201610540396.8A Withdrawn CN106177373A (zh) 2014-11-10 2014-11-10 一种含有大蒜挥发油的亲水性压敏胶
CN201410626937.XA Active CN104399112B (zh) 2014-11-10 2014-11-10 含有大蒜挥发油的亲水性压敏胶及其制备方法
CN201610540395.3A Withdrawn CN106177372A (zh) 2014-11-10 2014-11-10 抗感染、促进伤口愈合的含有大蒜挥发油的亲水性压敏胶
CN201610540404.9A Pending CN106075547A (zh) 2014-11-10 2014-11-10 抗感染的含有大蒜挥发油的亲水性压敏胶
CN201610540570.9A Withdrawn CN106075548A (zh) 2014-11-10 2014-11-10 含有大蒜挥发油的亲水性压敏胶

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CN201610540403.4A Withdrawn CN106177374A (zh) 2014-11-10 2014-11-10 一种抗感染的含有大蒜挥发油的亲水性压敏胶
CN201610540396.8A Withdrawn CN106177373A (zh) 2014-11-10 2014-11-10 一种含有大蒜挥发油的亲水性压敏胶

Family Applications After (3)

Application Number Title Priority Date Filing Date
CN201610540395.3A Withdrawn CN106177372A (zh) 2014-11-10 2014-11-10 抗感染、促进伤口愈合的含有大蒜挥发油的亲水性压敏胶
CN201610540404.9A Pending CN106075547A (zh) 2014-11-10 2014-11-10 抗感染的含有大蒜挥发油的亲水性压敏胶
CN201610540570.9A Withdrawn CN106075548A (zh) 2014-11-10 2014-11-10 含有大蒜挥发油的亲水性压敏胶

Country Status (1)

Country Link
CN (6) CN106177374A (zh)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104706868A (zh) * 2015-03-31 2015-06-17 苏州维泰生物技术有限公司 一种活血化瘀亲水性压敏胶及其制备方法
CN104707166A (zh) * 2015-03-31 2015-06-17 苏州维泰生物技术有限公司 一种含香茅草挥发油的亲水性压敏胶及其制备方法
CN104707165A (zh) * 2015-03-31 2015-06-17 苏州维泰生物技术有限公司 一种抗菌亲水性压敏胶及其制备方法
CN104706975A (zh) * 2015-03-31 2015-06-17 苏州维泰生物技术有限公司 一种淡化疤痕亲水性压敏胶及其制备方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI615159B (zh) * 2017-07-07 2018-02-21 泰陞國際科技股份有限公司 液體皮膚保護組合物

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002188067A (ja) * 2000-12-19 2002-07-05 Kikusui Tape Kk 機能性粘着組成物およびそれを用いた機能性粘着材
CN1456630A (zh) * 2003-03-14 2003-11-19 天津大学 亲水性聚氨酯压敏胶及其制备方法
WO2014130940A1 (en) * 2013-02-22 2014-08-28 Eastern Maine Healthcare Services Antimicrobial blood pressure cuff cover

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1111044C (zh) * 2000-06-26 2003-06-11 第一军医大学珠江医院 一种大蒜注射液的制备方法
CN100546619C (zh) * 2005-07-15 2009-10-07 中国中医科学院中医基础理论研究所 一种大蒜挥发油的提取方法
CN101332281B (zh) * 2007-06-26 2011-04-13 中国农业大学 大蒜挥发油在制备防治败血性波氏杆菌药物中的应用
CN101524462B (zh) * 2009-04-21 2012-06-13 沈德铭 一种大蒜挥发油组合物及乳膏制剂的制备方法和其在制备用于治疗皮肤、粘膜微生物感染的药物中的应用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002188067A (ja) * 2000-12-19 2002-07-05 Kikusui Tape Kk 機能性粘着組成物およびそれを用いた機能性粘着材
CN1456630A (zh) * 2003-03-14 2003-11-19 天津大学 亲水性聚氨酯压敏胶及其制备方法
WO2014130940A1 (en) * 2013-02-22 2014-08-28 Eastern Maine Healthcare Services Antimicrobial blood pressure cuff cover

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104706868A (zh) * 2015-03-31 2015-06-17 苏州维泰生物技术有限公司 一种活血化瘀亲水性压敏胶及其制备方法
CN104707166A (zh) * 2015-03-31 2015-06-17 苏州维泰生物技术有限公司 一种含香茅草挥发油的亲水性压敏胶及其制备方法
CN104707165A (zh) * 2015-03-31 2015-06-17 苏州维泰生物技术有限公司 一种抗菌亲水性压敏胶及其制备方法
CN104706975A (zh) * 2015-03-31 2015-06-17 苏州维泰生物技术有限公司 一种淡化疤痕亲水性压敏胶及其制备方法

Also Published As

Publication number Publication date
CN106177373A (zh) 2016-12-07
CN106177372A (zh) 2016-12-07
CN106075548A (zh) 2016-11-09
CN106177374A (zh) 2016-12-07
CN104399112B (zh) 2016-09-28
CN106075547A (zh) 2016-11-09

Similar Documents

Publication Publication Date Title
CN104399112B (zh) 含有大蒜挥发油的亲水性压敏胶及其制备方法
CN103127213A (zh) 一种祛疤敷料
CN104399107A (zh) 含有连翘挥发油的亲水性压敏胶及其制备方法
CN203107355U (zh) 医用小腿固定套
CN105497960A (zh) 一种具有促进伤口愈合功效的医用敷料及制法
CN104398676A (zh) 含有白蔹挥发油的亲水性压敏胶及其制备方法
CN104435165A (zh) 含有天葵子挥发油的亲水性压敏胶及其制备方法
CN104435041A (zh) 含有蓍草挥发油的亲水性压敏胶及其制备方法
CN101134053A (zh) 一种能治疗烫伤的药物组合物
CN102430005A (zh) 一种治疗骨折的中药蜜丸
CN104707167B (zh) 一种枫香树脂‑甲壳素‑没食子酸压敏胶及其制备方法
CN102579743B (zh) 一种主治骨伤，退行性骨病的外用软膏及其制备方法
CN102247491B (zh) 治疗扭伤的外用中药
CN101721576A (zh) 一种治疗鸡眼的外敷药物
CN1977926A (zh) 一种具有促进创面伤口快速愈合的生药及其制剂
CN101653622A (zh) 双黄连无定形水凝胶药用敷料及其制备方法
CN101249187B (zh) 治疗颈腰椎间盘突出症的中药
CN105055623A (zh) 一种外敷膏的组成、制造及使用方法
KR20200056849A (ko) 상처 보호를 위한 천연원료를 함유하는 개성 표출형 디자인 밴드 및 이의 제조방법
CN105726599A (zh) 一种治疗糖尿病的药物
CN106728741A (zh) 一种治疗脚后跟干裂的组合物、脚膜及其制备方法
WO2024042533A1 (en) Herbal composition for treatment of foot corn
CN102166290B (zh) 一种治疗刺蛾幼虫螫伤的外敷药物
CN108653452A (zh) 一种治疗跌打损伤的外用膏药
CN103110716B (zh) 一种驳骨中药

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20160829

Address after: 266000 Licang, Qingdao, No. nine East water road, No. 320, No.

Applicant after: QINGDAO YULANXIANG BUSINESS SERVICE CO., LTD.

Address before: Wuzhong District town Suzhou city Jiangsu province 215128 gold Jinchang Road No. 360

Applicant before: Suzhou Vivotide Biotechnologies Co., Ltd.

C14 Grant of patent or utility model
GR01 Patent grant
TR01 Transfer of patent right

Effective date of registration: 20171221

Address after: No. 10, No. three, group three, Tang Ji Zhen Village, Lianshui County, Lianshui, Jiangsu

Patentee after: Gu Yukui

Address before: 266000 Licang, Qingdao, No. nine East water road, No. 320, No.

Patentee before: Qingdao Yulanxiang Commercial Services Co., Ltd.

TR01 Transfer of patent right
CP02 Change in the address of a patent holder

Address after: 210000 No. 140 Hanzhong Road, Gulou District, Nanjing City, Jiangsu Province

Patentee after: Gu Yukui

Address before: 223001 No. 10, Group 3, Daqiao Village, Tangji Town, Lianshui County, Huaian City, Jiangsu Province

Patentee before: Gu Yukui

CP02 Change in the address of a patent holder
TR01 Transfer of patent right

Effective date of registration: 20191118

Address after: 221000 No.55, industrial park, suyangshan Town, Pizhou City, Xuzhou City, Jiangsu Province

Patentee after: Pizhou Qiwei Food Technology Co., Ltd

Address before: 210000 No. 140, Hanzhoung Road, Gulou District, Jiangsu, Nanjing

Patentee before: Gu Yukui

TR01 Transfer of patent right