CN104398793A - 一种治疗放射性肺炎的中药组合物及其制备方法 - Google Patents

一种治疗放射性肺炎的中药组合物及其制备方法 Download PDF

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CN104398793A
CN104398793A CN201410589185.4A CN201410589185A CN104398793A CN 104398793 A CN104398793 A CN 104398793A CN 201410589185 A CN201410589185 A CN 201410589185A CN 104398793 A CN104398793 A CN 104398793A
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鲁桂青
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Abstract

本发明涉及中药制剂领域，特别涉及一种治疗放射性肺炎的中药组合物，由以下组分按照重量分数组成：桑叶(蜜炙)5-10份，款冬花5-10份，饴糖30-40份，玉竹5-15份，甘草3-9份，大黄(酒制)3-9份，茜草(生)5-15份，雷公藤3-9份，延胡索3-9份，紫苏梗3-9份，荔枝核5-15份，娑罗子3-9份，刺五加5-15份，扁豆10-20份。本发明所述的治疗放射性肺炎的中药组合物，按照中医理论配制而成，各味中药组合，发挥治疗放射性肺炎的疗效，中药制剂，毒副作用小，成本低，制备方法中将各组分超微粉碎，最大释放药物有效成分。

Description

一种治疗放射性肺炎的中药组合物及其制备方法
技术领域
本发明涉及中药制剂领域，特别涉及一种治疗放射性肺炎的中药组合物及其制备方法。
背景技术
放射性肺炎是在放射治疗后出现刺激性咳嗽，多数在放射治疗2～3个月后出现症状，个别在停止放射治疗半年后出现刺激性干咳，活动后加剧，伴有气急，心悸和胸痛。不发热或低热，偶有高热。随肺纤维化加剧逐渐出现呼吸困难。易发生呼吸道感染而使症状加重，出现发绀。
中医认为：热毒之邪侵势肺脏，灼伤脉络、气阴耗伤、淤血内阻引起的病症。传统治疗方法采用激素缓解症状，严重时停止放疗，并影响了患者的生活治疗。
发明内容
针对现有技术中存在的缺陷，本发明的目的在于提供一种治疗放射性肺炎的中药组合物及其制备方法。
本发明的技术方案如下：
一种治疗放射性肺炎的中药组合物，由以下组分按照重量分数组成：
桑叶(蜜炙)5-10份，款冬花5-10份，饴糖30-40份，玉竹5-15份，甘草3-9份，大黄(酒制)3-9份，茜草(生)5-15份，雷公藤3-9份，延胡索3-9份，紫苏梗3-9份，荔枝核5-15份，娑罗子3-9份，刺五加5-15份，扁豆10-20份。
在上述方案的基础上，治疗放射性肺炎的中药组合物，由以下组分按照重量分数组成：
桑叶(蜜炙)8份，款冬花8份，饴糖35份，玉竹10份，甘草6份，大黄(酒制)6份，茜草(生)10份，雷公藤6份，延胡索6份，紫苏梗6份，荔枝核10份，娑罗子6份，刺五加10份，扁豆15份。
一种治疗放射性肺炎的中药组合物，具体的制备方法如下：
(1)按量称取组合物中各组分，将除饴糖外的各组分超微粉碎至800目；
(3)将粉碎后的原料及饴糖加入到1000份水中浸泡30min，之后武火煮沸，改文火持续煎煮20min；
(4)冷却后过滤，弃掉滤渣，将药液浓缩至300份，即成。
本发明所述的中药组合物，以中医理论为基础，本发明组合物中：桑叶(蜜炙)：润肺止咳；款冬花：润肺下气、止咳化痰；饴糖：缓急止痛、润肺止咳；玉竹：滋阴润肺、生津；甘草：补中益气、润肺止咳、缓急止痛；为君药；大黄(酒制)：清热泻火、清热解毒、凉血止血、活血祛瘀；茜草(生)：凉血止血、活血化瘀；雷公藤：活血通络、消肿止痛；延胡索：活血行气、止痛；为臣药；饴糖：补脾益气；紫苏梗：发表散寒、理气宽中；荔枝核：理气止痛、祛瘀散滞；娑罗子：疏肝理气、宽中和胃；刺五加：益气健脾、补肾安神；扁豆：健脾化湿；为佐药；甘草：缓和药性、解毒，为使药。其中饴糖既作为为君药润肺止咳又作为佐药补脾益气，甘草既作为君药润肺止咳又作为使药缓和药性、解毒；本发明组合物相辅相成，共奏润肺止咳、清热、解毒、活血、健脾、理气之功效。
本发明所述的治疗放射性肺炎的中药组合物，按照中医理论配制而成，各味中药组合，发挥治疗放射性肺炎的疗效，中药制剂，毒副作用小，成本低，制备方法中将各组分超微粉碎，最大释放药物有效成分。
具体实施方式
实施例1
一种治疗放射性肺炎的中药组合物，由以下组分按照重量分数组成：(每份1g)
桑叶(蜜炙)5份，款冬花5份，饴糖30份，玉竹5份，甘草3份，大黄(酒制)3份，茜草(生)5份，雷公藤3份，延胡索3份，紫苏梗3份，荔枝核5份，娑罗子3份，刺五加5份，扁豆10份。
具体的制备方法如下：
(1)按量称取组合物中各组分，将除饴糖外的各组分超微粉碎至800目；
(3)将粉碎后的原料及饴糖加入到1000份水中浸泡30min，之后武火煮沸，改文火持续煎煮20min；
(4)冷却后过滤，弃掉滤渣，将药液浓缩至300份，即成。
实施例2
一种治疗放射性肺炎的中药组合物，由以下组分按照重量分数组成：(每份1g)
桑叶(蜜炙)8份，款冬花8份，饴糖35份，玉竹10份，甘草6份，大黄(酒制)6份，茜草(生)10份，雷公藤6份，延胡索6份，紫苏梗6份，荔枝核10份，娑罗子6份，刺五加10份，扁豆15份。
制备方法与实施例1相同。
实施例3
一种治疗放射性肺炎的中药组合物，由以下组分按照重量分数组成：(每份1g)
桑叶(蜜炙)10份，款冬花10份，饴糖40份，玉竹15份，甘草9份，大黄(酒制)9份，茜草(生)15份，雷公藤9份，延胡索9份，紫苏梗9份，荔枝核15份，娑罗子9份，刺五加5份，扁豆20份。
制备方法与实施例1相同。
临床疗效总结：
一般资料：本发明药物共治疗放疗急慢性放射性肺炎患者共56例，其中：男34例，女22例；年龄26-72岁，平均52.4岁。
诊断标准：根据放射治疗史，干性呛咳，进行性气急和胸部X线有炎症或纤维化改变可作出诊断，但应与肺部肿瘤恶化和转移性肿瘤相鉴别，以免误诊断续放射治疗；可造成死亡。支气管粘膜上皮经照射后常引起细胞间变，应与癌肿细胞慎加区别。
服药方法：服用实施例2制备的药物，每日1剂，分两次服用，每次150g，10天为一疗程，连续服用3个疗程。
疗效判断标准：
治愈：治愈：临床症状完全消失，胸部X线或CT检查正常。
好转：临床症状改善，胸部X线或CT检查炎症减轻。
无效：症状无改善或加重。
治疗效果：
本发明治疗56例患者：其中治愈42例、好转13例、未愈1例，有效率98.2％。
典型病例
1、王某，女，42岁，2010年4月乳癌术后放疗1月后，出现干咳，气急、低热之症。查体：呼吸音粗，胸部拍片提示：放射性肺炎。给予激素、抗生素治疗，效果不明显，后服用本发明实施例2制备的中药20剂后，临床症状完全消失，胸部CT检查正常，后再服用10剂巩固。
2、段某，男，48岁，食管癌放疗后20月，出现咳嗽、咳痰，抗生素使用效果不佳。胸部平片及CT提示：放射性肺炎。服用本发明实施例2制备的药物30剂后，临床症状完全消失，胸部X线检查正常。
上述参照实施例的详细描述，是说明性的而不是限定性的，可按照所限定范围列举出若干个实施例，因此在不脱离本发明总体构思下的变化和修改，应属本发明的保护范围之内。

Claims (3)

1.一种治疗放射性肺炎的中药组合物，其特征在于由以下组分按照重量分数组成：
桑叶(蜜炙)5-10份，款冬花5-10份，饴糖30-40份，玉竹5-15份，甘草3-9份，大黄(酒制)3-9份，茜草(生)5-15份，雷公藤3-9份，延胡索3-9份，紫苏梗3-9份，荔枝核5-15份，娑罗子3-9份，刺五加5-15份，扁豆10-20份。
2.根据权利要求1所述的治疗放射性肺炎的中药组合物，其特征在于由以下组分按照重量分数组成：
桑叶(蜜炙)8份，款冬花8份，饴糖35份，玉竹10份，甘草6份，大黄(酒制)6份，茜草(生)10份，雷公藤6份，延胡索6份，紫苏梗6份，荔枝核10份，娑罗子6份，刺五加10份，扁豆15份。
3.根据权利要求1或2所述的治疗放射性肺炎的中药组合物，其特征在于具体的制备方法如下：
(1)按量称取组合物中各组分，将除饴糖外的各组分超微粉碎至800目；
(3)将粉碎后的原料及饴糖加入到1000份水中浸泡30min，之后武火煮沸，改文火持续煎煮20min；
(4)冷却后过滤，弃掉滤渣，将药液浓缩至300份，即成。
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