CN104398714A - Medicament for treating insomnia and preparation method thereof - Google Patents

Medicament for treating insomnia and preparation method thereof Download PDF

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Publication number
CN104398714A
CN104398714A CN201410703956.8A CN201410703956A CN104398714A CN 104398714 A CN104398714 A CN 104398714A CN 201410703956 A CN201410703956 A CN 201410703956A CN 104398714 A CN104398714 A CN 104398714A
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tablet
medicine
capsule
pill
insomnia
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顾蔷怡
高春娟
冷盛君
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
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    • A61K36/8888—Pinellia
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    • A61K9/2806—Coating materials
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    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
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    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract

The invention relates to a medicament for treating insomnia and a preparation method thereof. The medicament is prepared from arillus longanae, semen zizyphi spinosae, raw fossil fragments, raw ostracean, rhizoma pinelliae preparata, poria cocos and ruddle according to a certain proportion through compatibility and has special curative effects of treating yin deficiency and yang excess, checking exuberant yang to ease mental strain, calming the liver and suppressing yang, cooling blood for hemostasis, invigorating heart and spleen, removing dampness to reduce phlegm, calming adverse-rising energy and alleviating vomiting, reinforcing spleen and stomach, quieting heart and calming the nerves, treating dizziness and insomnia and assisting in sleeping. The Chinese medicinal composition disclosed by the invention has an obvious effect of treating sleep disturbance and has no side effects. Moreover, capsules, tablets or pills are convenient to carry and are suitable for people who go on a business trip, go on a trip and the like to use.

Description

Medicine of a kind of Cure for insomnia and preparation method thereof
Technical field
The present invention relates to a kind of is Chinese medicine composition of crude drug and preparation method thereof by Chinese herbal medicine, relates to medicine of a kind of Cure for insomnia and preparation method thereof specifically.
Background technology
Modern society, life stress is larger, has a sleepless night more common, and the following two kinds of situations that mainly contain of insomnia cause: one is the impact of other diseases, as cough, vomiting etc. cause sleep disorder; Two is hyperactivity of YANG due to deficiency of YIN, and negative and positive are become estranged, and cause and lie awake all night.Western medical treatment insomnia uses tranquilizer more, although tranquilizer treatment sleep disorder has good therapeutical effect, toxic side effect, can cause acute or chronic poisoning.Once take in a large number and can cause acute poisoning into stable class medicine and go into a coma even dead, long-term taking is stable can cause chronic poisoning, can cause that body is become thin, lassitude, pale complexion, skin are matt, sexual disorder, and insomnia, lather, depressed etc.Western medicine tranquilizer can only use the short time, can not life-time service, can only take stopgap measures and can not effect a permanent cure.
Current treatment by Chinese herbs insomnia is main mainly with decoction, for going on business, the people outside such as travelling, cannot carry.
Summary of the invention
In order to solve the problem, the present invention, from clinical treatment medication demand and the dialectical principle of traditional Chinese medical science prescription, proposes medicine of a kind of Cure for insomnia and preparation method thereof.It is the medicament be prepared from by the crude drug of following parts by weight proportioning: Arillus Longan 12-18g, Semen Ziziphi Spinosae 3-13g, Os Draconis 17-23g, Concha Ostreae 17-23g, Rhizoma Pinelliae 3-8g, Poria 3-8g, Haematitum 17-23g.Optimum ratio is: Arillus Longan 15g, Semen Ziziphi Spinosae 10g, Os Draconis 20g, Concha Ostreae 20g, Rhizoma Pinelliae 5g, Poria 5g, Haematitum 20g.Described medicament is oral liquid, capsule, tablet or pill.
The preparation method step of described capsule, tablet, pill is as follows:
(1) in the side of getting, Arillus Longan, Semen Ziziphi Spinosae, Os Draconis, Concha Ostreae, Rhizoma Pinelliae, Poria, Haematitum pulverize screen analysis;
(2) decocted with water 2-3 time by the mixture of sieve series in step (1), collecting decoction, filtration, worry liquid is condensed into 70-80 when spending, capsule, pill relative density are the thick paste of 1.0-1.6, and tablet relative density is the thick paste of 1.0-1.4;
(3) when making capsule, pill:
By thick paste separation and purification, drying, make dry granule; By dry granule mix homogeneously, in filled capsules, namely make capsule; Dry granule spray is added refined honey, mix homogeneously, makes piller and namely make pill;
When making tablet:
2-4 part starch is mixed homogeneously with the thick paste in step (2), makes granule, drying, make dry granule, dry granule is pressed into tablet, sugar coating, namely makes tablet.
Mixture described in step (2), the preferred number of times decocted with water is 2 times, and first time is 60-80 minute, and second time is 40-60 minute.
the pharmacology of medicine material medicine of the present invention is as follows:
Arillus Longan: have invigorating the heart and spleen, effect of nourishing blood to tranquillize the mind, cures mainly insufficiency of vital energy and blood, severe palpitation, forgetful insomnia, blood deficiency and yellow complexion.
Semen Ziziphi Spinosae: have the effects such as relieving mental strain and helping sleep, analgesia, cooling, nourishing the liver, arresting sweating, can treat seriousness insomnia.
Os Draconis: five OS DRACONISs (medical material OsDraconis (FossiliaOssiaMastodi) raw ore thing FossiliaOssisMastrodi) are irregular bulk, each 7-10cm of length and width, thick about 3cm.Surface cream white, above has pewter and rufous decorative pattern, and depth thickness is different, slightly the striped of chrysodor.Slightly gloss, occasionally has rimala.Matter is hard, easily peels off layer by layer, sth.s made by twisting can be broken, hygroscopicity by force, licks it with tongue, adsorbable on tongue.Distribution Sichuan, Shanxi, Shandong, Hebei, the Inner Mongol, Henan, Shaanxi, Gansu, Qinghai.[effect] gives birth to product subduing hyperactive YANG to ease mental disorders, for hyperactivity of YANG due to deficiency of YIN, and irritable, palpitation and insomnia, has a dizzy spell, demented frightened disease such as grade; Forging rear merit restrains astringent or styptic treatment for spontaneous sweating partially, and be used for premature ejaculation of passing out semen, leukorrhagia metrorrhagia, sweating due to debility chronic diarrhea, eczema prurigo, the open sore part is not held back, traumatic hemorrhage etc.In addition, forge and grind external, energy removing dampness sore, controls again eczema flowing water, with the passing of time unhealed.
Concha Ostreae: salty, is slightly cold.Return liver, gallbladder, kidney channel.[product efficacy] suppressing the hyperactive liver and subsiding YANG; Tranquillization with heavy prescription; Hard masses softening and resolving; Restrain astringent or styptic treatment for spontaneous sweating.There is YIN nourishing, nourish blood, tonifying five ZANG-organs, invigorate blood circulation, fill the effects such as flesh.[treatment disease] cures mainly vertigo and tinnitus; Palpitation with fear insomnia; Scrofula goiter; Lump in the abdomen mass in the abdomen; Spontaneous sweating; Seminal emission; Metrorrhagia; Leukorrhagia.
Rhizoma Pinelliae: have drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass effect, controls damp-phlegm cold drink, vomiting, regurgitation, cough with asthma abundant expectoration, chest and diaphragm distension, and syncope due to accumulation of phlegm is had a headache, dizzy sleeplessness.
Poria: the function with promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.
Haematitum: phonetic name: D à i Zh ě Sh í, having another name called palpus ball, red soil, fourth head Haematitum, blood teacher, purple Zhu, Haematitum, native Zhu, ferrum Zhu, ailhead Haematitum, nail Haematitum, red Haematitum, red stone, Haematitum, is the Ore of oxide-based mineral bloodstone.Main product in Hebei, Shanxi, Shandong, Henan, Hunan, Guangdong, the ground such as Sichuan, remove earth impurity after digging out and just obtain this product.Function cures mainly: suppressing the hyperactive liver town is inverse, cooling blood for hemostasis.Control eructation vomiting, dysphagia and regurgitation, asthma, infantile convulsion, spit blood, epistaxis, hemorrhoidal hamorrhage, hemorrhoid complicated by anal fistula, bleeding not during menses.
The present invention for monarch drug, is used for the treatment of hyperactivity of YANG due to deficiency of YIN, subduing hyperactive YANG to ease mental disorders, suppressing the hyperactive liver and subsiding YANG, cooling blood for hemostasis with Os Draconis, Concha Ostreae, Haematitum; With Arillus Longan, Semen Ziziphi Spinosae for ministerial drug, cooling arresting sweating, invigorating the heart and spleen, nourishing blood to tranquillize the mind, sleeping; Assistant, with Poria, makes with Rhizoma Pinelliae, and for drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming, syncope due to accumulation of phlegm is had a headache, dizzy sleeplessness.Medicine of the present invention holds the marrow of the traditional Chinese medical science, rigorous prescription, and all medicine monarch share, and mends broken combination, brings out the best in each other, meet the principle of traditional Chinese medical science medicine law and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs.
Acute toxicity test: larger dose and take to the growth of rat without remarkable toxicity compared with long-term therapy, have no overt toxicity damage to the chip form inspection such as brain, the heart, liver, kidney of rat and change, test display, this medicine has no side effect to health.
beneficial effect
Chinese medicine composition of the present invention is to hyperactivity of YANG due to deficiency of YIN, and subduing hyperactive YANG to ease mental disorders, suppressing the hyperactive liver and subsiding YANG, cooling blood for hemostasis, invigorating the heart and spleen, drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming, dizzy sleeplessness, sleeping has special efficacy.Chinese medicine composition of the present invention achieves noticeable achievement to treatment sleep disorder, and has no side effect.And, no matter be capsule, tablet or pill, easy to carry, be applicable to going on business, the people outside such as travelling use.
clinical trial:
1, case is selected
Suffers from case 45 example of sleep disorder, wherein male 21 example, women 24 example, 32 years old mean age.
2, diagnostic criteria
Job and life stress is large, daytime tired mind, night sleeplessness white collar, without other disorders affect.
3, therapeutic scheme
Made capsule in embodiment 2, under first 1 hour clothes of sleeping, each 4-6 grain, every 0.3g.
4, the standard of curative effect evaluation
Cure: sleep disorder disappears, recover the length of one's sleep normal, or more than 6 hours, sleep deep, energetic after waking up;
Effective: sleep disorder disappears substantially, sleep is clearly better, and the length of one's sleep increases, and Depth of sleep increases;
Invalid: the unchanged improvement of sleep disorder;
Total effective rate=cure rate+effective percentage.
5, data statistics
Case load Cure Effectively Invalid Cure rate Total effective rate
45 43 2 0 95.55% 100%
6, conclusion
Carry out test of cure by the white collar patient 45 examples being suffered to sleep disorder disease, take medicine capsule of the present invention, cure 43 examples, cure rate reaches 95.55%, effective 2 examples, and invalid 0 example, total effective rate reaches 100%.Chinese medicine composition of the present invention achieves noticeable achievement to treatment sleep disorder.
Detailed description of the invention
embodiment 1:medicine of a kind of Cure for insomnia and preparation method thereof.It is the medicament be prepared from by the crude drug of following parts by weight proportioning: Arillus Longan 12-18g, Semen Ziziphi Spinosae 3-13g, Os Draconis 17-23g, Concha Ostreae 17-23g, Rhizoma Pinelliae 3-8g, Poria 3-8g, Haematitum 17-23g.Described medicament is oral liquid, capsule, tablet or pill.
According to following portions by weight proportioning weighting raw materials:
Arillus Longan 12-18g, Semen Ziziphi Spinosae 3-13g, Os Draconis 17-23g, Concha Ostreae 17-23g, Rhizoma Pinelliae 3-8g, Poria 3-8g, Haematitum 17-23g.
The preparation method step of described capsule, tablet, pill is as follows:
(1) in the side of getting, Arillus Longan, Semen Ziziphi Spinosae, Os Draconis, Concha Ostreae, Rhizoma Pinelliae, Poria, Haematitum pulverize screen analysis;
(2) decocted with water 2-3 time by the mixture of sieve series in step (1), collecting decoction, filtration, worry liquid is condensed into 70-80 when spending, capsule, pill relative density are the thick paste of 1.0-1.6, and tablet relative density is the thick paste of 1.0-1.4;
(3) when making capsule, pill:
By thick paste separation and purification, drying, make dry granule; By dry granule mix homogeneously, in filled capsules, namely make capsule; Dry granule spray is added refined honey, mix homogeneously, makes piller and namely make pill;
When making tablet:
2-4 part starch is mixed homogeneously with the thick paste in step (2), makes granule, drying, make dry granule, dry granule is pressed into tablet, sugar coating, namely makes tablet.
Mixture described in step (2), the preferred number of times decocted with water is 2 times, and first time is 60-80 minute, and second time is 40-60 minute.
embodiment 2:medicine of a kind of Cure for insomnia and preparation method thereof.It is the medicament be prepared from by the crude drug of following parts by weight proportioning: Arillus Longan 15g, Semen Ziziphi Spinosae 10g, Os Draconis 20g, Concha Ostreae 20g, Rhizoma Pinelliae 5g, Poria 5g, Haematitum 20g.Described medicament is oral liquid, capsule, tablet or pill.
According to following portions by weight proportioning weighting raw materials:
Arillus Longan 15g, Semen Ziziphi Spinosae 10g, Os Draconis 20g, Concha Ostreae 20g, Rhizoma Pinelliae 5g, Poria 5g, Haematitum 20g.
The preparation method step of described capsule, tablet, pill is as follows:
(1) in the side of getting, Arillus Longan, Semen Ziziphi Spinosae, Os Draconis, Concha Ostreae, Rhizoma Pinelliae, Poria, Haematitum pulverize screen analysis;
(2) decocted with water 2-3 time by the mixture of sieve series in step (1), collecting decoction, filtration, worry liquid is condensed into 70-80 when spending, capsule, pill relative density are the thick paste of 1.0-1.6, and tablet relative density is the thick paste of 1.0-1.4;
(3) when making capsule, pill:
By thick paste separation and purification, drying, make dry granule; By dry granule mix homogeneously, in filled capsules, namely make capsule; Dry granule spray is added refined honey, mix homogeneously, makes piller and namely make pill;
When making tablet:
2-4 part starch is mixed homogeneously with the thick paste in step (2), makes granule, drying, make dry granule, dry granule is pressed into tablet, sugar coating, namely makes tablet.
Mixture described in step (2), the preferred number of times decocted with water is 2 times, and first time is 60-80 minute, and second time is 40-60 minute.
Embodiment 3: medicine of the present invention can also be decoction, oral liquid, granule etc.

Claims (5)

1. a medicine for Cure for insomnia, is characterized in that it is the medicament be prepared from by the crude drug of following parts by weight proportioning: Arillus Longan 12-18g, Semen Ziziphi Spinosae 3-13g, Os Draconis 17-23g, Concha Ostreae 17-23g, Rhizoma Pinelliae 3-8g, Poria 3-8g, Haematitum 17-23g.
2. the medicine of Cure for insomnia according to claim 1, is characterized in that it is the medicament be prepared from by the crude drug of following parts by weight proportioning: Arillus Longan 15g, Semen Ziziphi Spinosae 10g, Os Draconis 20g, Concha Ostreae 20g, Rhizoma Pinelliae 5g, Poria 5g, Haematitum 20g.
3. the medicine of Cure for insomnia according to claim 1 and 2, is characterized in that: described medicament is oral liquid, capsule, tablet or pill.
4. the medicine of Cure for insomnia according to claim 3, is characterized in that: the preparation method step of described capsule, tablet, pill is as follows:
(1) in the side of getting, Arillus Longan, Semen Ziziphi Spinosae, Os Draconis, Concha Ostreae, Rhizoma Pinelliae, Poria, Haematitum pulverize screen analysis;
(2) decocted with water 2-3 time by the mixture of sieve series in step (1), collecting decoction, filtration, worry liquid is condensed into 70-80 when spending, capsule, pill relative density are the thick paste of 1.0-1.6, and tablet relative density is the thick paste of 1.0-1.4;
(3) when making capsule, pill:
By thick paste separation and purification, drying, make dry granule; By dry granule mix homogeneously, in filled capsules, namely make capsule; Dry granule spray is added refined honey, mix homogeneously, makes piller and namely make pill;
When making tablet:
2-4 part starch is mixed homogeneously with the thick paste in step (2), makes granule, drying, make dry granule, dry granule is pressed into tablet, sugar coating, namely makes tablet.
5. the preparation method of the medicine of Cure for insomnia according to claim 4, is characterized in that the mixture described in step (2), and the number of times decocted with water is 2 times, and first time is 60-80 minute, and second time is 40-60 minute.
CN201410703956.8A 2014-11-30 2014-11-30 Medicament for treating insomnia and preparation method thereof Pending CN104398714A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106822633A (en) * 2017-01-11 2017-06-13 葛龙海 Mind easing

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