CN104383491A

CN104383491A - Traditional Chinese medicine composition for treating chronic diarrhea

Info

Publication number: CN104383491A
Application number: CN201410664436.0A
Authority: CN
Inventors: 王正琦
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-11-20
Filing date: 2014-11-20
Publication date: 2015-03-04

Abstract

The invention provides a traditional Chinese medicine composition for treating chronic diarrhea. The traditional Chinese medicine composition is characterized by being prepared from the following traditional Chinese medicine materials in parts by weight: 50 parts of rhizoma zingiberis, 50 parts of morinda officinalis, 10 parts of cassia twig, 10 parts of Chinese herbaceous peony, 5 parts of cinnamon, 30 parts of poria cocos, 50 parts of Chinese yam, 10-20 parts of prepared common monkshood daughter root, 6 parts of red dates, 30 parts of white hyacinth bean, 10 parts of astragalus membranaceus and 10 parts of honey-fried licorice root. The traditional Chinese medicine composition has the efficacies of clearing away heat and toxic materials, reinforcing qi and nourishing blood, tonifying the spleen and warming the middle warmer, and dispelling cold and relieving pain, and has a good treatment effect on chronic diarrhea.

Description

A kind of Traditional Chinese drug mixture for the treatment of chronic diarrhea

Technical field:

The present invention relates to technical field of Chinese medicine, is exactly specifically a kind of Traditional Chinese drug mixture for the treatment of chronic diarrhea.

Background technology:

Diarrhoea refers to that defecation frequency is significantly more than the frequency be on ordinary days accustomed to, and excrement matter is thin, and every day, Fecal wastes was more than 200g, or containing non-digest food or pus and blood.Chronic diarrhea refers to the diarrhoea of the course of disease more than two months or the intermission recurrent diarrhoea within 2-4 week.Chronic diarrhea belongs to functional diarrhea, refers to diarrhoea that bowel dysfunction causes, comprises adaptive colitis, diarrhoea that emotionality, dyspepsia cause.Symptoms has stomachache flatulence, pain or disappearance after exhaust defecation, loose stool with firmly just alternately occur.The chronic diarrhea course of disease is delayed, recurrent exerbation, can reach the several months, the several years do not heal.Antibiotic therapy is taked in current treatment more, but side effect is large mostly, and therapeutic effect is undesirable.

Summary of the invention:

The present invention is exactly to overcome deficiency of the prior art, provide a kind for the treatment of for chronic diarrhea have treating both the principal and secondary aspects of a disease, curative effect obviously, to control recurrence rate after healing low, and the Traditional Chinese drug mixture that side effect is little.

The invention provides technical scheme:

Treat a Traditional Chinese drug mixture for chronic diarrhea, it is characterized in that being made up of the raw material of Chinese medicine of following weight proportion: Rhizoma Zingiberis 25-60 part, Radix Morindae Officinalis 25-60 part, Ramulus Cinnamomi 5-20 part, Radix Paeoniae 5-20 part, Cortex Cinnamomi 5-15 part, Poria 20-45 part, Rhizoma Dioscoreae 25-60 part, Radix Aconiti Lateralis Preparata 10-20 part, Fructus Jujubae 5-15 part, Semen Lablab Album 20-45 part, Radix Astragali 5-20 part, Radix Glycyrrhizae Preparata 5-20 part.

Optimization formula is:

Rhizoma Zingiberis 50 parts, Radix Morindae Officinalis 50 parts, Ramulus Cinnamomi 10 parts, Radix Paeoniae 10 parts, Cortex Cinnamomi 5 parts, 30 parts, Poria, Rhizoma Dioscoreae 50 parts, Radix Aconiti Lateralis Preparata 13 parts, Fructus Jujubae 6 parts, Semen Lablab Album 30 parts, the Radix Astragali 10 parts, Radix Glycyrrhizae Preparata 10 parts.

Preparation and instructions of taking:

Get above-mentioned each raw material of Chinese medicine by weight ratio, first Radix Aconiti Lateralis Preparata is decocted 2 hours decoction liquor for subsequent use, then other raw material is decocted 3 times together, after all decoction liquor being merged, be condensed into 90ML, the fill of every 45ML bottle.

Every bu early, take for twice evening, each one bottle (45NL), serveing on 5 days is a course for the treatment of.Period in a medicine avoids pungent, greasy product.

The pharmacological effect forming each raw material of Chinese medicine of the present invention is described as follows:

Rhizoma Zingiberis: acrid in the mouth, hot in nature.Return spleen, stomach, kidney, the heart, lung meridian.The effects such as have warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant.Be usually used in coldness and pain in the epigastrium, vomiting is had loose bowels, cold extremities faint pulse, and phlegm retention such as to be breathed with cough the disease.Rhizoma Zingiberis preserved material can suppress gastric acidity and gastric secretion, and it suppresses the effect of stress ulcer, and zoopery shows: this product preserved material to stress gastric ulcer, acetic acid brings out gastric ulcer, Pylorus Ligated Gastric Ulcer all obvious inhibitory action.In addition, ginger ale extract and Rhizoma Zingiberis volatile oil gavage can obviously prevent the formation of Rat Experimental thrombosis. and ginger ale decocting liquid has prolongation clotting time and makes the partly soluble effect of fibrin. and Rhizoma Zingiberis preserved material has obvious inhibitory action to the frog vomiting that peripheral emetic copper sulfate brings out.

Radix Morindae Officinalis: sweet in the mouth, pungent, slightly warm in nature.Return kidney, Liver Channel.There is kidney-replenishing, strengthening bone and muscle, the effects such as wind-damp dispelling.Be usually used in sexual impotence, few abdomen cold type of pain, incontinence of urine, deficiency-cold of uterus, anemofrigid-damp arthralgia, the diseases such as soreness of waist and knee joint.This product also has puts on weight and resisting fatigue, suppression atrophy of thymus gland and increase blood middle leukocytes quantity, to increase in blood the effects such as corticosterone content, blood pressure lowering, antiinflammatory.

Ramulus Cinnamomi: acrid in the mouth, sweet, warm in nature.GUIXIN, lung, urinary bladder channel.There is diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation, supporing yang activating QI, the effects such as dispersing cold for relieving pain.Be usually used in anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, the diseases such as renal mass.This product also has blood vessel dilating, regulates blood circulation, antipyretic, analgesia, calmness, convulsion, antiinflammatory, antiallergic, the effect such as antibacterial.

Radix Paeoniae: cool in nature, bitter in the mouth acid, is slightly cold, has blood-supplementing blood-nourishing, suppressing liver-YANG, easing the affected liver to relieve pain.The effects such as astringing YIN to stop sweating, are applicable to fever due to yin deficiency, menoxenia, the breast abdomen pain over the hypochondriac region, extremity contraction suddenly, dysentery stomachache, spontaneous sweating, metrorrhagia, the inferior disease of band.In this product, contained paeoniflorin has antibacterial, antipyretic, antiinflammatory, increase coronary flow, improves the effect of myocardial nutritional flow, blood vessel dilating, antagonism acute myocardial ischemia, anticoagulant, calmness, analgesia, spasmolytic, antiulcer, adjustment blood glucose; Radix Paeoniae Alba decoct can suppress dysentery bacterium, streptococcus pneumoniae, escherichia coli, Bacillus typhi, Hemolytic streptococcus, bacillus pyocyaneus etc.In addition, research shows: the phagocytic function of the Radix Paeoniae Alba to macrophage has potentiation.

Cortex Cinnamomi: acrid in the mouth, sweet, extremely hot in nature.Return kidney, spleen, the heart, Liver Channel.There is benefit fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, the effects such as promoting blood circulation to restore menstrual flow.Be usually used in for sexual impotence, cold womb, chills and pain of the waist and kness, suffer from a deficiency of the kidney and breathe heavily, dizziness due to yang deficiency, conjunctival congestion pharyngalgia, trusted subordinate's cold type of pain, deficiency and coldness is vomited and diarrhoea, colic of cold type, renal mass, amenorrhea, the diseases such as dysmenorrhea.Experiment shows: the cinnamic aldehyde contained in Cortex Cinnamomi is to the obvious sedation of mice Ke; All cooling effect is had to mice normal body temperature and by the artificial fever that typhoid fever, paratyphoid fever mixed vaccine cause; There is hypotensive effect; Oleum Cinnamomi has powerful bactericidal action.

Poria: sweet in the mouth, light, property are put down.GUIXIN, lung, spleen, kidney channel.There is eliminating dampness and diuresis; Invigorating the spleen and regulating the stomach; The effects such as mind tranquilizing and the heart calming.Be usually used in dysuria; Edema distension; Phlegm retention cough with dyspnea; Vomiting; Insufficiency of the spleen lack of appetite; Have loose bowels; Palpitation and restlessness; Insomnia forgetfulness; The diseases such as seminal emission nebulousurine.Experiment shows: pachyman contained in this product, hydroxyethyl pachyman-3, hydroxyethyl pachyman-4, lumbar injection obviously can strengthen the cytotoxic effect of mouse peritoneal exudate cells; Pachyman, hydroxyethyl pachyman-1, hydroxyethyl pachyman-2 also have certain effect.Test with novel carboxymethyl pachyman, result shows to strengthen PEC cytotoxic effect, and cytophagous phagocytic rate and phagocytic index are obviously increased.In addition, methylol pachyman obviously can strengthen mice spleen antibody secreting cell number and special antigen binding cell number; Pachyman physical ability strengthens cell immune response, and therefore activates the immune surveillance system of body to tumor, and this and its anti-tumor activity is closely related.

Rhizoma Dioscoreae: sweet in the mouth, property is put down.Return spleen, lung, kidney channel.There is spleen reinforcing nourishing the stomach, the effects such as promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.Be usually used in insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, and deficiency-heat such as to be quenched one's thirst the disease.Rhizoma Dioscoreae is rich in multivitamin, aminoacid and mineral, can prevent and treat Human Lipid Metabolism abnormal, and arteriosclerosis, to safeguarding that insulin normal function also has certain effect, there is enhancing body immunity, beneficial heart and tranquilizing mind, rather cough Dingchuan, the health-care effects such as slow down aging; Improve the immunity of body, strengthen the phagocytosis of macrophage.In addition, Rhizoma Dioscoreae Aqueous extracts also can eliminate urine protein, mutant cell is had to the effect suppressing to produce.

Radix Aconiti Lateralis Preparata: acrid in the mouth, sweet, extremely hot in nature; Poisonous.GUIXIN, kidney, spleen channel.There is recuperating depleted YANG and rescuing the patient from collapse, mend fire supporing yang, by effects such as wind-cold damp pathogens.Be usually used in YANG-depletion collapse, cold extremities faint pulse, sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness is vomited and diarrhoea, YIN-cold edema, yang deficiency diseases caused by exogenous pathogenic factor, the diseases such as arthralgia due to cold-dampnes.This product also has expansion peripheral blood vessel, improves mouse humoral immune function and guinea pig serum complement content, arrhythmia, analgesia, calmness, antiinflammatory and the effect such as heart tonifying and boosting.

Fructus Jujubae: sweet in the mouth, warm in nature.Return spleen, stomach warp.There is spleen reinforcing stomach function regulating, supplementing QI for promoting the production of body fluid, adjust battalion to defend, separate the effects such as poison of drug.Be commonly used to treatment insufficiency of stomach lack of appetite, the weak loose stool of spleen, qi-blood-body fluid is not enough, disharmony of nutrient QI with defensive QI, severe palpitation.Married woman's stolen goods are hot-tempered waits disease.This product has the function of invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind, the mitigation property of medicine; The pharmacology in modern times then finds, Fructus Jujubae contains protein, fat, carbohydrate, organic acid, vitamin A, vitamin C, micro-calcium are multiple.Fructus Jujubae can improve body immunity, and can anticancer: pharmacological research finds, Fructus Jujubae can promote leukocytic generation; reduce serum cholesterol, improve serum albumin, the liver protecting; also containing anticancer in Fructus Jujubae, cancerous cell even can be made to the material of normal cell turnover.Often the people of edible fresh Fructus Jujubae seldom suffers from cholelithiasis, this is because vitamin C abundant in fresh Fructus Jujubae, makes cholesterol unnecessary in body change bile acid into, little cholesterol, lithogenous probability also just reduces thereupon.Calcium and ferrum is rich in Fructus Jujubae; they to preventing and treating osteoporosis, postpartum anemia plays an important role; middle-aged and elderly people climacteric often understands osteoporosis; easily there is anemia in the teenager just on growth promoter peak and women; Fructus Jujubae has very good dietary function to them, and its effect normally medicine can not compared.Also good tonic effect is had to the people of body void after being ill.Rutin contained by Fructus Jujubae is that one makes arteriosclerosis, thus the material that blood pressure is reduced, there is prophylactic-therapeutic effect to hypertension.Fructus Jujubae can also antiallergic, except stench strange taste, mind tranquilizing and the heart calming, brain healthy, appetite strengthening.Fructus Jujubae can also well can muscle strength reinforcing, allaying tiredness, blood vessel dilating, increase myocardial contraction, improve myocardial nutrition.Fructus Jujubae contains a large amount of glucides, is mainly glucose, also containing fructose, sucrose, and oligosaccharide, arabinan and the galacturonan etc. that are made up of glucose and fructose; And containing a large amount of multivitamins such as vitamin C, riboflavin, thiamine, carotene, nicotinic acid, there is stronger tonic effect, immune function of human body can be improved, strengthen resistance against diseases.The effect that Fructus Jujubae has muscle strength reinforcing and puts on weight.Fructus Jujubae has hepatoprotective effect.Fructus Jujubae ethanol extraction, to atopic diseases, can suppress the generation of antibody, also has inhibitory action to mice reactive antibody, and prompting Fructus Jujubae has anti-allergy action.It is contained in Fructus Jujubae that flavone--two-glycoside A has calmness, hypnosis and hypotensive effect, the naringenin C glucoside be wherein separated has central inhibitory action, namely reduce autonomic movement and stimulate reflection, tetanic numb effect, thus Fructus Jujubae have calm the nerves, the merit of calmness.Fructus Jujubae is containing multiple three these compounds, and wherein firelight or sunlight wood acid, crataegus pin natifida var. Major acid all find that there is active anticancer, have inhibitory action to sarcoma S-180.Nutrient contained in Fructus Jujubae, can strengthen immune function of human body, has certain effect for cancer-resisting and maintenance human-body viscera function.

Semen Lablab Album: sweet in the mouth, type tepor.Return spleen, stomach warp.There is invigorating the spleen for eliminating dampness, and in the effect such as to relieve summer heat.Be usually used in weakness of the spleen and stomach, inappetence, diarrhea, leukorrhagia, heat-damp in summer is vomited and diarrhoea, the diseases such as abdominal distention uncomfortable in chest.The dull and stereotyped paper disk method of Semen Lablab Album decoct, to dysentery bacterium and have inhibitory action; Detoxication is had to vomiting, acute gastroenteritis etc. that alimentary toxicosis causes; Have and strengthen the lymphocytic activity of T, improve the immunologic function of cell;

The Radix Astragali: sweet in the mouth, slightly warm in nature.Return lung, spleen, liver, kidney channel.There is the effects such as benefiting QI for strengthening the superficies, arresting sweating are admittedly de-, holder skin ulcer granulation promoting, inducing diuresis to remove edema.Be usually used in the treatment deficiency of vital energy weak, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst, chronic nephritis, albuminuria, the diseases such as diabetes.This product has enhancing human body immunity function, protects the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.Jishengshenqiwan albuminuria can be eliminated, strengthen myocardial contraction, regulate blood sugar content.The Radix Astragali can not only coronary artery dilator, improves blood supply of cardiac muscle, improves immunologic function, and can the process of delaying cell aging.

Radix Glycyrrhizae: sweet in the mouth, property is put down.Return stomach, lung, spleen channel.There is invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the effects such as coordinating the actions of various ingredients in a prescription.Be usually used in weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, the disease such as strong.This product has removing toxic substances, eliminates the phlegm, pain relieving, spasmolytic, anticancer, conditioner body immunity function, arrhythmia, blood fat reducing, anti- atherosclerosis, anticoagulant, the pharmacological action such as antitumor.

Inventor thinks that the sick position of chronic diarrhea is mainly at intestinal, but dirty close relation all with taste Liver and kidney, mostly be weakness of the spleen and stomach, dyspepsia gastrointestinal and deficiency of kidney yang, liver is lost bar and reaches, and cold and heat are not normal, and intestinal flora is disorderly.So often simulataneous insufficiency and excessive, touching difficulty more.Set out for this viewpoint, the efficacy of a drug coordination, the compatibility that form each raw material of the present invention are reasonable, have heat-clearing and toxic substances removing, benefiting QI and nourishing blood, spleen reinforcing warming middle-JIAO, effect that cold expelling relieves the pain, the treatment for chronic diarrhea have treating both the principal and secondary aspects of a disease, curative effect obviously, to control recurrence rate after healing low, and the advantage such as side effect is little.

Detailed description of the invention:

Embodiment 1:

Treat a Traditional Chinese drug mixture for chronic diarrhea, it is characterized in that being made up of the raw material of Chinese medicine of following weight proportion: Rhizoma Zingiberis 50 parts, Radix Morindae Officinalis 50 parts, Ramulus Cinnamomi 10 parts, Radix Paeoniae 10 parts, Cortex Cinnamomi 5 parts, 30 parts, Poria, Rhizoma Dioscoreae 50 parts, Radix Aconiti Lateralis Preparata 13 parts, Fructus Jujubae 6 parts, Semen Lablab Album 30 parts, the Radix Astragali 10 parts, Radix Glycyrrhizae Preparata 10 parts.

Embodiment 2:

Treat a Traditional Chinese drug mixture for chronic diarrhea, it is characterized in that being made up of the raw material of Chinese medicine of following weight proportion: Rhizoma Zingiberis 25 parts, Radix Morindae Officinalis 25 parts, Ramulus Cinnamomi 10 parts, Radix Paeoniae 15 parts, Cortex Cinnamomi 12 parts, 25 parts, Poria, Rhizoma Dioscoreae 35 parts, Radix Aconiti Lateralis Preparata 10 parts, Fructus Jujubae 5 parts, Semen Lablab Album 20 parts, the Radix Astragali 8 parts, Radix Glycyrrhizae Preparata 8 parts.

Embodiment 3:

Treat a Traditional Chinese drug mixture for chronic diarrhea, it is characterized in that being made up of the raw material of Chinese medicine of following weight proportion: Rhizoma Zingiberis 55 parts, Radix Morindae Officinalis 55 parts, Ramulus Cinnamomi 13 parts, Radix Paeoniae 17 parts, Cortex Cinnamomi 10 parts, 20 parts, Poria, Rhizoma Dioscoreae 60 parts, Radix Aconiti Lateralis Preparata 10 parts, Fructus Jujubae 12 parts, Semen Lablab Album 40 parts, the Radix Astragali 15 parts, Radix Glycyrrhizae Preparata 15 parts.

General data:

The present invention be applied to clinical observation case 160 example, wherein man 76 example, female 84 example, age 18-64 year.

Diagnostic criteria:

(1) soft stools or as water sample, increased frequency, can accompany abdominal distention colic symptoms;

(2) chronic chronic diarrhea onset is slow, and the course of disease is longer, recurrent exerbation, time light time heavy;

(3) improper diet, can bring out by cold and cool or emotion changes;

(4) barium enema of X line or intestinal fiberscopy is made if desired.

Usage and dosage:

During clinical practice, every bu early, take for twice evening, each one bottle (45NL), period in a medicine avoids pungent, greasy product.

Criterion of therapeutical effect:

Cure: stool is normal, other transference cures, and Clinical Laboratory is normal;

Effective: times of defecation obviously reduces, other symptoms are improved;

Effective: to defecate rare or become water sample, but times of defecation and amount take a turn for the better before comparatively treating to some extent;

Invalid: after treatment, symptom is without improvement.

Therapeutic effect:

In this clinical observation case, take medicine 1-6 the course for the treatment of, recovery from illness 83 example, effective 40 examples, effective 31 examples, invalid 6 examples; There is not toxic and side effects in treatments period.

Model case:

1, patient poplar, man 49 years old.To suffer from diarrhoea 3 wheat harvesting periods, defecate for water sample or half congealed without mucus, every day 6-8 time, suffer from abdominal pain once in a while, check upper abdomen B ultrasonic, intestinal mirror, gastroscope, blood biochemistry, stool routine examination are all normal, have an injection, to take Western medicine invalid, take 1 course for the treatment of of medicament prepared by Traditional Chinese drug mixture of the present invention, symptom alleviates to some extent, and stool is dry not rare, continues to strengthen 4 courses for the treatment of of treatment, stool is normal, recovery from illness.

Claims

1. treat a Traditional Chinese drug mixture for chronic diarrhea, it is characterized in that being made up of the raw material of Chinese medicine of following weight proportion: Rhizoma Zingiberis 25-60 part, Radix Morindae Officinalis 25-60 part, Ramulus Cinnamomi 5-20 part, Radix Paeoniae 5-20 part, Cortex Cinnamomi 5-15 part, Poria 20-45 part, Rhizoma Dioscoreae 25-60 part, Radix Aconiti Lateralis Preparata 10-20 part, Fructus Jujubae 5-15 part, Semen Lablab Album 20-45 part, Radix Astragali 5-20 part, Radix Glycyrrhizae Preparata 5-20 part.

2., according to a kind of Traditional Chinese drug mixture for the treatment of chronic diarrhea described in claim 1, it is characterized in that being made up of the raw material of Chinese medicine of following weight proportion: Rhizoma Zingiberis 50 parts, Radix Morindae Officinalis 50 parts, Ramulus Cinnamomi 10 parts, Radix Paeoniae 10 parts, Cortex Cinnamomi 5 parts, 30 parts, Poria, Rhizoma Dioscoreae 50 parts, Radix Aconiti Lateralis Preparata 13 parts, Fructus Jujubae 6 parts, Semen Lablab Album 30 parts, the Radix Astragali 10 parts, Radix Glycyrrhizae Preparata 10 parts.