CN104383308B - Two one careless amino acid zymotic fluids and preparation method thereof - Google Patents

Two one careless amino acid zymotic fluids and preparation method thereof Download PDF

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CN104383308B
CN104383308B CN201410569712.5A CN201410569712A CN104383308B CN 104383308 B CN104383308 B CN 104383308B CN 201410569712 A CN201410569712 A CN 201410569712A CN 104383308 B CN104383308 B CN 104383308B
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amino acid
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金凤章
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GUANGXI JIN CHEN TECHNOLOGY Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/19—Acanthaceae (Acanthus family)
    • A61K36/195—Strobilanthes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/062—Ascomycota
    • A61K36/064—Saccharomycetales, e.g. baker's yeast
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A61K36/315—Isatis, e.g. Dyer's woad
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction

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Abstract

The present invention discloses a kind of two one careless amino acid zymotic fluids and preparation method thereof, it is related to zymotic fluid technical field, its composition includes 57 parts of Radix Isatidis, 57 parts of rhizoma imperatae, dry 57 parts of radix glycyrrhizae, 0.5 1 parts of honey, 0.5 1 parts of oligosaccharides, 0.02 0.04 parts of dry ferment, 50 parts of water, preparation method is by Radix Isatidis, rhizoma imperatae and dry radix glycyrrhizae are prepared with water in proportion after crushing with honey, oligosaccharides, dry ferment, are loaded in tank, and sealing and fermenting is until send vinegar fragrance, then the zymotic fluid is processed refinement with supercritical fluid extraction isolation technics, produced；This zymotic fluid is pure natural zymotic fluid, without any side effects using safety；Show by clinical test, treat conjunctivitis using this zymotic fluid, short treating period, curative effect is notable.

Description

Two one careless amino acid zymotic fluids and preparation method thereof
Technical field
The present invention relates to zymotic fluid technical field, especially a kind of two one careless amino acid zymotic fluids and preparation method thereof.
Background technology
Conjunctivitis（conjunctivitis）It is the common disease of ophthalmology, is due to that conjunctiva is most of straight with the external world more its cause of disease Contact, easily by infectious in surrounding environment, such as bacterium, virus and Chlamydia, and non-infective agent such as wound, chemistry The stimulation of material and physical factor etc..Conjunctivitis is the inflammatory that conjunctival tissue occurs in the effect of extraneous and body oneself factor The general designation of reaction.Some conjunctiva inflammation sustainable several months or several years, particularly ectropion, entropion, lacrimal passage disease, chemicals Allergy, some pungents of contact or the infection of certain peculiar microorganism（Such as Chlamydia）Caused conjunctivitis.Through Canonical management Afterwards, conjunctivitis is not general to eyesight influence serious in itself, but can cause when its inflammation involves cornea or causes complication to regard Power is damaged, or even blindness.
With the improvement of sanitary condition, the diseases prevention rate of infective conjunctivitis is gradually decreased, and Lung infection type conjunctivitis cases It is more and more.Because the reason for non-infectious conjunctivitis based on poor environment and life style, including dust, smog, The stimulation of dust storm, strong light and pernicious gas；Often stay up late, have not enough sleep, thermophilic cigarette excessively, with kopiopia etc., especially for a long time Operating computer or surfing Internet with cell phone are very big to eye injury, and one side computer asthenopia syndrome can cause conjunctivitis symptoms, another Aspect, xerophthalmia can also cause or aggravate conjunctivitis caused by computer；Furthermore, it is also former that some cosmetics or medicament for the eyes, which are used for a long time, Therefore one.
The easy recurrent exerbation of conjunctivitis, it is obstinate refractory, very big pain is brought to patient, therefore, seeks a kind of safe and effective Medicine come to treat conjunctivitis be one of the problem of pharmaceuticals industry is paid close attention to.
The content of the invention
Problem to be solved by this invention, which is to provide a kind of use safety, the treatment to conjunctivitis, has remarkable result and system Standby simple two one careless amino acid zymotic fluids and preparation method thereof.
In order to solve the above-mentioned technical problem, the technical scheme used is：Its composition includes the original of following parts by weight Material：5-7 parts of Radix Isatidis, 5-7 parts of rhizoma imperatae, dry radix glycyrrhizae 5-7 parts, 0.5-1 parts of honey, 0.5-1 parts of oligosaccharides, dry ferment 0.02- 0.04 part, 50 parts of water.
In above-mentioned technical proposal, more specifically scheme can also be：Its composition includes the raw material of following parts by weight：
5 parts of Radix Isatidis, 5 parts of rhizoma imperatae, dry 5 parts of radix glycyrrhizae, 0.5 part of honey, 0.5 part of oligosaccharides, 0.02 part of dry ferment, water 50 Part.
Further：Its composition includes the raw material of following parts by weight：
7 parts of Radix Isatidis, 7 parts of rhizoma imperatae, dry 7 parts of radix glycyrrhizae, 1 part of honey, 1 part of oligosaccharides, 0.04 part of dry ferment, 50 parts of water.
Its preparation method comprises the following steps：
（1）, by Radix Isatidis, rhizoma imperatae and dry radix glycyrrhizae crush, cross 100 ~ 150 mesh sieves；
（2）, will（1）Step gains are prepared with water in proportion with honey, oligosaccharides, dry ferment, are loaded in tank, sealing and fermenting 15 ~ 25 days, send vinegar fragrance；
（3）, by step（2）Gained zymotic fluid is processed refinement with supercritical fluid extraction isolation technics, produces this hair Zymotic fluid.
In the above method, the tank is plastic tank；The water is pure water.
Radix Isatidis of the present invention, alias：Indigo-blue, indigo root, manyflower glorybower root, are a kind of Chinese medicines.Radix Isatidis is divided into Northern Radix Isatidis and rhizoma et Radix Baphicacanthis Cusiae, northern Radix Isatidis source is cruciferae isatis（Isatis tinctoria L.）Root；South Radix Isatidis is acanthaceous vegetable acanthaceous indigo（Baphicacanthus cusia (Nees) Brem.）Rhizome and root, with heat-clearing The effect of removing toxic substances, preventing cold, relieving sore-throat, bitter.
Rhizoma imperatae of the present invention, is grass perennial herb cogongrass（Scientific name：Imperata cylindrica ）Rhizome.Alias：Lalang grass rhizome, manage, Ru Gen, Lan Gen.Cure mainly：Cooling blood and hemostasis, it is clearing heat and detoxicating.For spitting blood, Hematuria, heat gonorrhea, oedema, jaundice, difficult urination, pyreticosis polydipsia, stomach hot vomiting, cough.
Due to using above-mentioned technical proposal, the present invention compared with prior art, have the advantage that for：
Because this zymotic fluid is to be formed using pure Chinese medicine fermentation, had no side effect using safety；Show by clinical test, make Conjunctivitis is treated with this zymotic fluid, short treating period, curative effect is notable.
Embodiment
Below in conjunction with example, the invention will be further described：
Embodiment 1 --- the careless amino acid zymotic fluids of two one of 66.02 kilograms of preparation：
Using the raw material of following parts by weight：5 kilograms of Radix Isatidis, 5 kilograms of rhizoma imperatae, dry 5 kilograms of radix glycyrrhizae, first-class honey 0.5 Kilogram, first-class 0.5 kilogram of oligosaccharides, 0.02 kilogram of high activity dried yeast, 50 kilograms of pure water；
Its preparation method is：
（1）, by 5 kilograms of Radix Isatidis, 150 mesh sieves are crossed in the 5 kilograms of crushing of 5 kilograms of rhizoma imperatae and dry radix glycyrrhizae；
（2）, will（1）0.02 kilogram of 0.5 kilogram of step gains and honey, 0.5 kilogram of oligosaccharides and high activity dried yeast with 50 kilograms of pure water is prepared, and is loaded in plastic tank, sealing and fermenting 20 days sends vinegar fragrance；
（3）, by step（2）Gained zymotic fluid is processed refinement with supercritical carbon dioxide extraction technology, carries out Processing is refined, and produces this two careless amino acid zymotic fluids.
Embodiment 2 --- the careless amino acid zymotic fluids of two one of 73.04 kilograms of preparation：
Using the raw material of following parts by weight：7 kilograms of Radix Isatidis, 7 kilograms of rhizoma imperatae, dry 7 kilograms of radix glycyrrhizae, 1 kilogram of honey is few 1 kilogram of sugar, 0.04 kilogram of dry ferment, 50 kilograms of pure water；
Its preparation method is：
（1）, by 7 kilograms of Radix Isatidis, 100 mesh sieves are crossed in 7 kilograms of rhizoma imperatae, dry 7 kilograms of crushing of radix glycyrrhizae；
（2）, will（1）0.04 kilogram of 1 kilogram of step gains and honey, 1 kilogram of oligosaccharides and high activity dried yeast are with 50,000 Gram pure water prepare, load plastic tank in, sealing and fermenting 15 days sends vinegar fragrance；
（3）, by step（2）Gained zymotic fluid is processed refinement with supercritical carbon dioxide extraction technology, carries out Processing is refined, and produces this two careless amino acid zymotic fluids.
Clinical test part：
General information：Total case load is 45, and the age is 18-60 Sui, and all cases all suffer from conjunctivitis.
Case is randomly divided into 3 groups, every group 15, one group of zymotic fluid for being provided using the embodiment of the present invention 1 is instilled every time Eyes 1-2 drops, it is daily sooner or later each 1 time；One group of zymotic fluid for being provided using the embodiment of the present invention 2, instills eyes 3-5 drops every time, One time a day；3rd group is used using the medicine for being commonly used for treating conjunctivitis, routinely application method.
Clinically treatment results count such as table 1：
Table 1

Claims (5)

1. a kind of be used to treat two one of conjunctivitis careless amino acid zymotic fluids, it is characterised in that it by following parts by weight raw material It is made：5-7 parts of Radix Isatidis, 5-7 parts of rhizoma imperatae, dry radix glycyrrhizae 5-7 parts, 0.5-1 parts of honey, 0.5-1 parts of oligosaccharides, dry ferment 0.02- 0.04 part, 50 parts of water.
2. according to claim 1 be used to treat two one of conjunctivitis careless amino acid zymotic fluids, it is characterised in that it by The raw material of following parts by weight is made：
5 parts of Radix Isatidis, 5 parts of rhizoma imperatae, dry 5 parts of radix glycyrrhizae, 0.5 part of honey, 0.5 part of oligosaccharides, 0.02 part of dry ferment, 50 parts of water.
3. according to claim 1 be used to treat two one of conjunctivitis careless amino acid zymotic fluids, it is characterised in that it by The raw material of following parts by weight is made：
7 parts of Radix Isatidis, 7 parts of rhizoma imperatae, dry 7 parts of radix glycyrrhizae, 1 part of honey, 1 part of oligosaccharides, 0.04 part of dry ferment, 50 parts of water.
4. a kind of preparation method for two one careless amino acid zymotic fluids for being used to treat conjunctivitis, it is characterised in that：
Using the raw material of following parts by weight：5-7 parts of Radix Isatidis, 5-7 parts of rhizoma imperatae, dry radix glycyrrhizae 5-7 parts, 0.5-1 parts of honey, oligosaccharides 0.5-1 parts, 0.02-0.04 parts of dry ferment, 50 parts of water；
Its preparation method comprises the following steps：
（1）, by Radix Isatidis, rhizoma imperatae and dry radix glycyrrhizae crush, cross 100 ~ 150 mesh sieves；
（2）, will（1）Step gains are prepared with water in proportion with honey, oligosaccharides, dry ferment, are loaded in tank, and sealing and fermenting 15 ~ 25 days, send vinegar fragrance；
（3）, by step（2）Gained zymotic fluid is processed refinement with supercritical fluid extraction isolation technics, produces this zymotic fluid.
5. the preparation method of two one careless amino acid zymotic fluids according to claim 4 for being used to treat conjunctivitis, it is special Levy and be：The tank is plastic tank；The water is pure water.
CN201410569712.5A 2014-10-23 2014-10-23 Two one careless amino acid zymotic fluids and preparation method thereof Active CN104383308B (en)

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CN102524704A (en) * 2012-03-10 2012-07-04 柳州市金臣科技有限公司 Fructus momordicae fermentation liquor and making method thereof

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JP3983003B2 (en) * 2001-03-15 2007-09-26 株式会社ファンケル Glutathione enhancing composition

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CN102524704A (en) * 2012-03-10 2012-07-04 柳州市金臣科技有限公司 Fructus momordicae fermentation liquor and making method thereof

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