CN104379589A - 抗血小板药剂的前药 - Google Patents

抗血小板药剂的前药 Download PDF

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Publication number
CN104379589A
CN104379589A CN201380030644.9A CN201380030644A CN104379589A CN 104379589 A CN104379589 A CN 104379589A CN 201380030644 A CN201380030644 A CN 201380030644A CN 104379589 A CN104379589 A CN 104379589A
Authority
CN
China
Prior art keywords
compound
independently
formula
pharmaceutical composition
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201380030644.9A
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English (en)
Chinese (zh)
Inventor
M·坎杜拉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cellix Bio Pvt Ltd
Original Assignee
Cellix Bio Pvt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/IB2012/053673 external-priority patent/WO2013024376A1/fr
Application filed by Cellix Bio Pvt Ltd filed Critical Cellix Bio Pvt Ltd
Publication of CN104379589A publication Critical patent/CN104379589A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CN201380030644.9A 2012-05-07 2013-03-24 抗血小板药剂的前药 Pending CN104379589A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IN1781CH2012 2012-05-07
IN1781/CHE/2012 2012-05-07
PCT/IB2012/053673 WO2013024376A1 (fr) 2011-08-16 2012-07-19 Compositions et procédés pour le traitement de l'athérotrombose
IBPCT/IB2012/053673 2012-07-19
PCT/IB2013/052328 WO2013168024A1 (fr) 2012-05-07 2013-03-24 Promédicaments d'agents antiplaquettaires

Publications (1)

Publication Number Publication Date
CN104379589A true CN104379589A (zh) 2015-02-25

Family

ID=54193687

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380030644.9A Pending CN104379589A (zh) 2012-05-07 2013-03-24 抗血小板药剂的前药

Country Status (8)

Country Link
EP (1) EP2847197A4 (fr)
JP (1) JP2015519334A (fr)
CN (1) CN104379589A (fr)
AU (1) AU2013257745A1 (fr)
CA (1) CA2873094A1 (fr)
SG (1) SG11201407307YA (fr)
WO (1) WO2013168024A1 (fr)
ZA (1) ZA201408064B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114507157A (zh) * 2020-11-17 2022-05-17 沧州维智达美制药有限公司 一种利用氯乙腈制备溴乙腈的方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104583162A (zh) * 2012-07-03 2015-04-29 塞利克斯比奥私人有限公司 治疗中度至重度疼痛的组合物和方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004094374A2 (fr) * 2003-04-23 2004-11-04 Rhodia Pharma Solutions Inc. (Formally Rhodia Chirex Inc.) Preparation de (s)-clopidogrel et composes associes
WO2005046575A2 (fr) * 2003-07-29 2005-05-26 Signature R & D Holdings, Lcc Prodrogues a base d'acides amines
EP1889835A1 (fr) * 2005-05-27 2008-02-20 Daiichi Sankyo Company, Limited Dérivé d'amine cyclique ayant un groupe alkyle substitué
EP2298777A2 (fr) * 2008-06-09 2011-03-23 Enzytech, Ltd. Procédé de préparation de clopidogrel et de ses dérivés
CN102002053A (zh) * 2009-09-02 2011-04-06 陕西合成药业有限公司 用于治疗的四氢噻吩并吡啶衍生物
CN102336767A (zh) * 2011-07-11 2012-02-01 华东理工大学 制备高纯度手性α-取代-6,7-二氢噻吩并[3,2-c]吡啶衍生物的方法
WO2013024376A1 (fr) * 2011-08-16 2013-02-21 Mahesh Kandula Compositions et procédés pour le traitement de l'athérotrombose

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9525998B2 (en) * 2012-01-06 2016-12-20 Qualcomm Incorporated Wireless display with multiscreen service
KR102094050B1 (ko) * 2012-01-27 2020-03-27 인터디지탈 패튼 홀딩스, 인크 다중 캐리어 기반형 및/또는 의사 조합형 네트워크에서 epdcch를 제공하는 시스템 및/또는 방법
CA2872975A1 (fr) * 2012-05-07 2013-11-14 Cellixbio Private Limited Compositions et methodes de traitement de troubles neurologiques
CN104797568A (zh) * 2012-05-08 2015-07-22 塞利克斯比奥私人有限公司 用于治疗神经障碍的组合物和方法
EP2847161A4 (fr) * 2012-05-08 2015-12-23 Cellix Bio Private Ltd Compositions et méthodes de traitement du diabète
JP2015526385A (ja) * 2012-05-08 2015-09-10 セリックスビオ プライヴェート リミテッド てんかんの治療のための組成物及び方法
WO2013167994A1 (fr) * 2012-05-08 2013-11-14 Mahesh Kandula Compositions et méthodes inhibant l'activité de l'anhydrase carbonique
CN104583162A (zh) * 2012-07-03 2015-04-29 塞利克斯比奥私人有限公司 治疗中度至重度疼痛的组合物和方法

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004094374A2 (fr) * 2003-04-23 2004-11-04 Rhodia Pharma Solutions Inc. (Formally Rhodia Chirex Inc.) Preparation de (s)-clopidogrel et composes associes
WO2005046575A2 (fr) * 2003-07-29 2005-05-26 Signature R & D Holdings, Lcc Prodrogues a base d'acides amines
EP1889835A1 (fr) * 2005-05-27 2008-02-20 Daiichi Sankyo Company, Limited Dérivé d'amine cyclique ayant un groupe alkyle substitué
EP2298777A2 (fr) * 2008-06-09 2011-03-23 Enzytech, Ltd. Procédé de préparation de clopidogrel et de ses dérivés
CN102002053A (zh) * 2009-09-02 2011-04-06 陕西合成药业有限公司 用于治疗的四氢噻吩并吡啶衍生物
CN102336767A (zh) * 2011-07-11 2012-02-01 华东理工大学 制备高纯度手性α-取代-6,7-二氢噻吩并[3,2-c]吡啶衍生物的方法
WO2013024376A1 (fr) * 2011-08-16 2013-02-21 Mahesh Kandula Compositions et procédés pour le traitement de l'athérotrombose

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
KATRIN SANGKUHL，等: "Clopidogrel pathway", 《PHARMACOGENET GENOMICS》 *
MIHO KAZUI，等: "Identification of the Human Cytochrome P450 Enzymes Involved in the Two Oxidative Steps in the Bioactivation of Clopidogrel to Its Pharmacologically Active Metabolite", 《DRUG METABOLISM AND DISPOSITION》 *
PATRICK M. DANSETTE，等: "Formation and Fate of a Sulfenic Acid Intermediate in the Metabolic Activation of the Antithrombotic Prodrug Prasugrel", 《CHEM. RES. TOXICOL.》 *
张青山，等: "新型抗血小板药氯吡格雷研究进展", 《化工进展》 *
荆亚萍，等: "新一代血小板抑制剂——普拉格雷", 《国际药学研究杂志》 *
陈继方，等: "氯吡格雷类似物的合成及其抗血小板聚集活性", 《合成化学》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114507157A (zh) * 2020-11-17 2022-05-17 沧州维智达美制药有限公司 一种利用氯乙腈制备溴乙腈的方法

Also Published As

Publication number Publication date
CA2873094A1 (fr) 2013-11-14
EP2847197A4 (fr) 2015-11-04
WO2013168024A1 (fr) 2013-11-14
JP2015519334A (ja) 2015-07-09
AU2013257745A1 (en) 2014-11-27
EP2847197A1 (fr) 2015-03-18
SG11201407307YA (en) 2014-12-30
ZA201408064B (en) 2016-04-28

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Application publication date: 20150225