WO2013168024A1 - Promédicaments d'agents antiplaquettaires - Google Patents
Promédicaments d'agents antiplaquettaires Download PDFInfo
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- WO2013168024A1 WO2013168024A1 PCT/IB2013/052328 IB2013052328W WO2013168024A1 WO 2013168024 A1 WO2013168024 A1 WO 2013168024A1 IB 2013052328 W IB2013052328 W IB 2013052328W WO 2013168024 A1 WO2013168024 A1 WO 2013168024A1
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- 239000008117 stearic acid Substances 0.000 description 1
- 125000003696 stearoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 229920006132 styrene block copolymer Polymers 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 231100001274 therapeutic index Toxicity 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 235000019149 tocopherols Nutrition 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 238000013271 transdermal drug delivery Methods 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 206010044652 trigeminal neuralgia Diseases 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- 235000014692 zinc oxide Nutrition 0.000 description 1
- QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Definitions
- a is independently 2,3 or 7;
- each b is i ndependently 3, 5 or 6;
- polymorph as used herein is art-recognized and refers to one crystal structure of a. given compound.
- the compounds of Formulas i may be administered at a dose of, for example, less than 0.2 mg kg day, 0.5 mg/kg/day, 1.0 mg/kg day, 5 mg/kg/day, 10 mg/kg/day, 20 mg/kg/day, 30 mg kg day, or 40 mg/kg/day.
- Compounds of Formula I, formula 11, formula la or formula Il may also be administered to a human patient at a dose of, for example, between 0. 1 mg and 1000 mg, between 5 nig and 80 mg, or less than 1.0. 9.0, 12.0, 20.0, 50.0, 75.0, 100, 300, 400, 500, 800, 1000, 2000, 5000 mg per day.
- a method for the manufacture of the above-mentioned substrate sheet comprises preparing the above resin composition molding the resin composition into a composite film by a calendar process, and then adhering a polyaikyiene terephthaiate film on. one side of the composite film by means of an adhesive layer thereby forming the substrate sheet, and forming a primer layer comprising a saturated polyester resin on the outer surface of the polyaikyiene terephthaiate film.
- c and d are each independently H, D, -OH, -OD, C Qralkyi, - H? or -COC3 ⁇ 4.
- M ihi is for using compounds of formula I:
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La présente invention concerne des composés de formule I, de formule II, de formule Ia, de formule IIb ou bien ses sels pharmaceutiquement acceptables, ses formes polymorphes, ses solvates, ses énantiomères, ses stéréo-isomères et ses hydrates. Les compositions pharmaceutiques comprennent une quantité efficace de composés de formule I, de formule II, de formule Ia, de formule IIb et peuvent être utilisées pour le traitement ou la prise en charge de l'ischémie, de l'accident vasculaire cérébral, de la thrombose cérébrale, de la thrombose artérielle, des maladies cérébrovasculaires thrombotiques, cardiovasculaires et des caillots de sang.
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201380030644.9A CN104379589A (zh) | 2012-05-07 | 2013-03-24 | 抗血小板药剂的前药 |
| EP13787471.5A EP2847197A4 (fr) | 2012-05-07 | 2013-03-24 | Promédicaments d'agents antiplaquettaires |
| AU2013257745A AU2013257745A1 (en) | 2012-05-07 | 2013-03-24 | Prodrugs of anti-platelet agents |
| CA2873094A CA2873094A1 (fr) | 2012-05-07 | 2013-03-24 | Promedicaments d'agents antiplaquettaires |
| JP2015510901A JP2015519334A (ja) | 2012-05-07 | 2013-03-24 | 抗血小板薬のプロドラッグ |
| SG11201407307YA SG11201407307YA (en) | 2012-05-07 | 2013-03-24 | Prodrugs of anti-platelet agents |
| PCT/IB2014/058090 WO2014118649A2 (fr) | 2013-01-19 | 2014-01-07 | Compositions et méthodes pour le traitement de maladies cardiovasculaires |
| ZA2014/08064A ZA201408064B (en) | 2012-05-07 | 2014-11-04 | Prodrugs of anti-platelet agents |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1781CH2012 | 2012-05-07 | ||
| IN1781/CHE/2012 | 2012-05-07 | ||
| PCT/IB2012/053673 WO2013024376A1 (fr) | 2011-08-16 | 2012-07-19 | Compositions et procédés pour le traitement de l'athérotrombose |
| IBPCT/IB2012/053673 | 2012-07-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2013168024A1 true WO2013168024A1 (fr) | 2013-11-14 |
Family
ID=54193687
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/IB2013/052328 WO2013168024A1 (fr) | 2012-05-07 | 2013-03-24 | Promédicaments d'agents antiplaquettaires |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP2847197A4 (fr) |
| JP (1) | JP2015519334A (fr) |
| CN (1) | CN104379589A (fr) |
| AU (1) | AU2013257745A1 (fr) |
| CA (1) | CA2873094A1 (fr) |
| SG (1) | SG11201407307YA (fr) |
| WO (1) | WO2013168024A1 (fr) |
| ZA (1) | ZA201408064B (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201407328TA (en) * | 2012-07-03 | 2014-12-30 | Cellix Bio Private Ltd | Compositions and methods for the treatment of moderate to severe pain |
| CN114507157B (zh) * | 2020-11-17 | 2023-03-24 | 沧州维智达美制药有限公司 | 一种利用氯乙腈制备溴乙腈的方法 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005046575A2 (fr) * | 2003-07-29 | 2005-05-26 | Signature R & D Holdings, Lcc | Prodrogues a base d'acides amines |
| EP2298777A2 (fr) * | 2008-06-09 | 2011-03-23 | Enzytech, Ltd. | Procédé de préparation de clopidogrel et de ses dérivés |
| CN102002053A (zh) * | 2009-09-02 | 2011-04-06 | 陕西合成药业有限公司 | 用于治疗的四氢噻吩并吡啶衍生物 |
| CN102336767A (zh) * | 2011-07-11 | 2012-02-01 | 华东理工大学 | 制备高纯度手性α-取代-6,7-二氢噻吩并[3,2-c]吡啶衍生物的方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6858734B2 (en) * | 2003-04-23 | 2005-02-22 | Rhodia Pharma Solutions Inc. | Preparation of (S)-Clopidogrel and related compounds |
| CA2609852A1 (fr) * | 2005-05-27 | 2006-11-30 | Daiichi Sankyo Company, Limited | Derive d'amine cyclique ayant un groupe alkyle substitue |
| WO2013024376A1 (fr) * | 2011-08-16 | 2013-02-21 | Mahesh Kandula | Compositions et procédés pour le traitement de l'athérotrombose |
| US9525998B2 (en) * | 2012-01-06 | 2016-12-20 | Qualcomm Incorporated | Wireless display with multiscreen service |
| KR102094050B1 (ko) * | 2012-01-27 | 2020-03-27 | 인터디지탈 패튼 홀딩스, 인크 | 다중 캐리어 기반형 및/또는 의사 조합형 네트워크에서 epdcch를 제공하는 시스템 및/또는 방법 |
| JP2015519333A (ja) * | 2012-05-07 | 2015-07-09 | セリックスビオ プライヴェート リミテッド | 神経疾患の治療のための組成物および方法 |
| EP2847175A4 (fr) * | 2012-05-08 | 2016-04-20 | Cellix Bio Private Ltd | Compositions et méthodes inhibant l'activité de l'anhydrase carbonique |
| CN104797568A (zh) * | 2012-05-08 | 2015-07-22 | 塞利克斯比奥私人有限公司 | 用于治疗神经障碍的组合物和方法 |
| AU2013257707A1 (en) * | 2012-05-08 | 2014-11-27 | Cellixbio Private Limited | Compositions and methods for the treatment of epilepsy |
| EP2847161A4 (fr) * | 2012-05-08 | 2015-12-23 | Cellix Bio Private Ltd | Compositions et méthodes de traitement du diabète |
| SG11201407328TA (en) * | 2012-07-03 | 2014-12-30 | Cellix Bio Private Ltd | Compositions and methods for the treatment of moderate to severe pain |
-
2013
- 2013-03-24 EP EP13787471.5A patent/EP2847197A4/fr not_active Withdrawn
- 2013-03-24 CN CN201380030644.9A patent/CN104379589A/zh active Pending
- 2013-03-24 AU AU2013257745A patent/AU2013257745A1/en not_active Abandoned
- 2013-03-24 CA CA2873094A patent/CA2873094A1/fr not_active Abandoned
- 2013-03-24 SG SG11201407307YA patent/SG11201407307YA/en unknown
- 2013-03-24 WO PCT/IB2013/052328 patent/WO2013168024A1/fr active Application Filing
- 2013-03-24 JP JP2015510901A patent/JP2015519334A/ja active Pending
-
2014
- 2014-11-04 ZA ZA2014/08064A patent/ZA201408064B/en unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005046575A2 (fr) * | 2003-07-29 | 2005-05-26 | Signature R & D Holdings, Lcc | Prodrogues a base d'acides amines |
| EP2298777A2 (fr) * | 2008-06-09 | 2011-03-23 | Enzytech, Ltd. | Procédé de préparation de clopidogrel et de ses dérivés |
| CN102002053A (zh) * | 2009-09-02 | 2011-04-06 | 陕西合成药业有限公司 | 用于治疗的四氢噻吩并吡啶衍生物 |
| CN102336767A (zh) * | 2011-07-11 | 2012-02-01 | 华东理工大学 | 制备高纯度手性α-取代-6,7-二氢噻吩并[3,2-c]吡啶衍生物的方法 |
Non-Patent Citations (1)
| Title |
|---|
| See also references of EP2847197A4 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2847197A1 (fr) | 2015-03-18 |
| CN104379589A (zh) | 2015-02-25 |
| CA2873094A1 (fr) | 2013-11-14 |
| JP2015519334A (ja) | 2015-07-09 |
| SG11201407307YA (en) | 2014-12-30 |
| ZA201408064B (en) | 2016-04-28 |
| EP2847197A4 (fr) | 2015-11-04 |
| AU2013257745A1 (en) | 2014-11-27 |
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